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10 results on '"Hayashi, Tomayoshi"'

2. Severe esophagitis directly induced by accumulation of crizotinib-residue at the esophageal mucosa proven with polarizing microscope examination

Author

Umeyama, Yasuhiro, Taniguchi, Hirokazu, Yamaguchi, Hiroyuki, Shimada, Midori, Sugasaki, Nanae, Kinoshita, Akitoshi, Hayashi, Tomayoshi, Abe, Kuniko, Ono, Sawana, Gyotoku, Hiroshi, Senju, Hiroaki, Ikeda, Takaya, Nakatomi, Katsumi, Fukuda, Minoru, Takemoto, Shinnosuke, and Mukae, Hiroshi

Subjects
esophagitis, Crizotinib, ALK, ROS-1, polarizing microscopes
Abstract

Crizotinib demonstrates dramatic effects for the patients with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase gene (ALK) fusion or c-ros oncogene 1 (ROS-1) fusion-positive lung cancer, with some characteristic toxicities. Although several studies reported that serious esophagitis was induced by crizotinib, the detailed mechanisms and ways to ameliorate the esophagitis have not been clarified. In this report, we report two cases with lung cancer who had been treated with crizotinib and developed severe esophagitis. Polarizing microscope examination clearly revealed that the accumulation of crizotinib-residue in the esophageal biopsy samples at the second anatomical narrowing of the esophagus in both cases. Since it seemed that the accumulation of crizotinib-residue in the esophageal mucosa directly caused the esophageal inflammation, we recommended taking crizotinib with a large amount of water (more than 200 ml) and to stay sitting upright for 30 minutes after intake. After that, the esophagitis gradually improved and the patients could continue taking crizotinib without dose reduction or withdrawal. Our experiences suggest that this crizotinib-induced esophagitis could be easily prevented by proper administration of crizotinib., Acta medica Nagasakiensia, 66(2), pp.99-103; 2023

Published
2023

3. Data from RET/PTC Rearrangements Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors Exposed to High Radiation Dose

Author

Hamatani, Kiyohiro, primary, Eguchi, Hidetaka, primary, Ito, Reiko, primary, Mukai, Mayumi, primary, Takahashi, Keiko, primary, Taga, Masataka, primary, Imai, Kazue, primary, Cologne, John, primary, Soda, Midori, primary, Arihiro, Koji, primary, Fujihara, Megumu, primary, Abe, Kuniko, primary, Hayashi, Tomayoshi, primary, Nakashima, Masahiro, primary, Sekine, Ichiro, primary, Yasui, Wataru, primary, Hayashi, Yuzo, primary, and Nakachi, Kei, primary

Published
2023
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4. Supplementary Figure 1 from RET/PTC Rearrangements Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors Exposed to High Radiation Dose

Author

Hamatani, Kiyohiro, primary, Eguchi, Hidetaka, primary, Ito, Reiko, primary, Mukai, Mayumi, primary, Takahashi, Keiko, primary, Taga, Masataka, primary, Imai, Kazue, primary, Cologne, John, primary, Soda, Midori, primary, Arihiro, Koji, primary, Fujihara, Megumu, primary, Abe, Kuniko, primary, Hayashi, Tomayoshi, primary, Nakashima, Masahiro, primary, Sekine, Ichiro, primary, Yasui, Wataru, primary, Hayashi, Yuzo, primary, and Nakachi, Kei, primary

Published
2023
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5. Supplementary Table 2 from RET/PTC Rearrangements Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors Exposed to High Radiation Dose

Author

Hamatani, Kiyohiro, primary, Eguchi, Hidetaka, primary, Ito, Reiko, primary, Mukai, Mayumi, primary, Takahashi, Keiko, primary, Taga, Masataka, primary, Imai, Kazue, primary, Cologne, John, primary, Soda, Midori, primary, Arihiro, Koji, primary, Fujihara, Megumu, primary, Abe, Kuniko, primary, Hayashi, Tomayoshi, primary, Nakashima, Masahiro, primary, Sekine, Ichiro, primary, Yasui, Wataru, primary, Hayashi, Yuzo, primary, and Nakachi, Kei, primary

Published
2023
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6. Supplementary Figure Legend from RET/PTC Rearrangements Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors Exposed to High Radiation Dose

Author

Hamatani, Kiyohiro, primary, Eguchi, Hidetaka, primary, Ito, Reiko, primary, Mukai, Mayumi, primary, Takahashi, Keiko, primary, Taga, Masataka, primary, Imai, Kazue, primary, Cologne, John, primary, Soda, Midori, primary, Arihiro, Koji, primary, Fujihara, Megumu, primary, Abe, Kuniko, primary, Hayashi, Tomayoshi, primary, Nakashima, Masahiro, primary, Sekine, Ichiro, primary, Yasui, Wataru, primary, Hayashi, Yuzo, primary, and Nakachi, Kei, primary

Published
2023
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7. Supplementary Table 1 from RET/PTC Rearrangements Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors Exposed to High Radiation Dose

Author

Hamatani, Kiyohiro, primary, Eguchi, Hidetaka, primary, Ito, Reiko, primary, Mukai, Mayumi, primary, Takahashi, Keiko, primary, Taga, Masataka, primary, Imai, Kazue, primary, Cologne, John, primary, Soda, Midori, primary, Arihiro, Koji, primary, Fujihara, Megumu, primary, Abe, Kuniko, primary, Hayashi, Tomayoshi, primary, Nakashima, Masahiro, primary, Sekine, Ichiro, primary, Yasui, Wataru, primary, Hayashi, Yuzo, primary, and Nakachi, Kei, primary

Published
2023
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