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4. Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.

Author

Sweha, Stefan, Mota, Mateus, Pun, Matthew, Deogharkar, Akash, Chung, Chan, Tarapore, Rohinton, Ramage, Samuel, Chi, Andrew, Wen, Patrick, Arrillaga-Romany, Isabel, Batchelor, Tracy, Butowski, Nicholas, Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca, de Groot, John, Mehta, Minesh, Hall, Matthew, Daghistani, Doured, Cloughesy, Timothy, Ellingson, Benjamin, Beccaria, Kevin, Varlet, Pascale, Kim, Michelle, Umemura, Yoshie, Garton, Hugh, Franson, Andrea, Schwartz, Jonathan, Jain, Rajan, Kachman, Maureen, Baum, Heidi, Burant, Charles, Mottl, Sophie, Cartaxo, Rodrigo, John, Vishal, Messinger, Dana, Qin, Tingting, Peterson, Erik, Sajjakulnukit, Peter, Ravi, Karthik, Waugh, Alyssa, Walling, Dustin, Ding, Yujie, Xia, Ziyun, Schwendeman, Anna, Hawes, Debra, Yang, Fusheng, Judkins, Alexander, Wahl, Daniel, Lyssiotis, Costas, de la Nava, Daniel, Alonso, Marta, Eze, Augustine, Spitzer, Jasper, Schmidt, Susanne, Duchatel, Ryan, Dun, Matthew, Cain, Jason, Jiang, Li, Stopka, Sylwia, Baquer, Gerard, Regan, Michael, Filbin, Mariella, Agar, Nathalie, Zhao, Lili, Kumar-Sinha, Chandan, Mody, Rajen, Chinnaiyan, Arul, Kurokawa, Ryo, Pratt, Drew, Yadav, Viveka, Grill, Jacques, Kline, Cassie, Venneti, Sriram, Kawakibi, Abed, Ji, Sunjong, Resnick, Adam, Nazarian, Javad, Allen, Joshua, Odia, Yazmin, Gardner, Sharon, Koschmann, Carl, Mueller, Sabine, and Waszak, Sebastian

Subjects
Humans, Glioma, Brain Neoplasms, Histones, Treatment Outcome, Epigenesis, Genetic, Mutation
Abstract

UNLABELLED: Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this finding remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/cerebrospinal fluid (CSF) correlate samples from patients treated in two completed multisite clinical studies. Patients treated with ONC201 following initial radiation but prior to recurrence demonstrated a median overall survival of 21.7 months, whereas those treated after recurrence had a median overall survival of 9.3 months. Radiographic response was associated with increased expression of key tricarboxylic acid cycle-related genes in baseline tumor sequencing. ONC201 treatment increased 2-hydroxyglutarate levels in cultured H3K27M-DMG cells and patient CSF samples. This corresponded with increases in repressive H3K27me3 in vitro and in human tumors accompanied by epigenetic downregulation of cell cycle regulation and neuroglial differentiation genes. Overall, ONC201 demonstrates efficacy in H3K27M-DMG by disrupting integrated metabolic and epigenetic pathways and reversing pathognomonic H3K27me3 reduction. SIGNIFICANCE: The clinical, radiographic, and molecular analyses included in this study demonstrate the efficacy of ONC201 in H3K27M-mutant DMG and support ONC201 as the first monotherapy to improve outcomes in H3K27M-mutant DMG beyond radiation. Mechanistically, ONC201 disrupts integrated metabolic and epigenetic pathways and reverses pathognomonic H3K27me3 reduction. This article is featured in Selected Articles from This Issue, p. 2293.

Published
2023

7. Cycle Threshold Values as Indication of Increasing SARS-CoV-2 New Variants, England, 2020-2022

Author

Harrison, Rebecca E., Hamada, Ahmed, Haswell, Nujcharee, Groves, Aigul, Vihta, Karina-Doris, Cella, Kerry, Garner, Sarah, Walker, Ann Sarah, and Seale, Anna C.

Subjects
Infection -- Health aspects -- Analysis, Health
Abstract

From identification of SARS-CoV-2 in December 2019 through September 22, 2022, [approximately equal to] 612 million confirmed cases and 6.5 million confirmed deaths were reported worldwide (1). During the COVID-19 [...]

Published
2023
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11. Merleau-Ponty and Standpoint Theory

Author

Harrison, Rebecca, de Warren, Nicolas, Series Editor, Toadvine, Ted, Series Editor, Alweiss, Lilian, Editorial Board Member, Behnke, Elizabeth, Editorial Board Member, Bernet, Rudolf, Editorial Board Member, Carr, David, Editorial Board Member, Cheung, Chan-Fai, Editorial Board Member, Dodd, James, Editorial Board Member, Ferrarin, Alfredo, Editorial Board Member, Hopkins, Burt, Editorial Board Member, Huertas-Jourda, José, Editorial Board Member, Lau, Kwok-Ying, Editorial Board Member, Lee, Nam-In, Editorial Board Member, Lohmar, Dieter, Editorial Board Member, McKenna, William R., Editorial Board Member, Mickunas, Algis, Editorial Board Member, Mohanty, J. N., Editorial Board Member, Moran, Dermot, Editorial Board Member, Murata, Junichi, Editorial Board Member, Nenon, Thomas, Editorial Board Member, Soffer, Gail, Editorial Board Member, Steinbock, Anthony, Editorial Board Member, Taguchi, Shigeru, Editorial Board Member, Zahavi, Dan, Editorial Board Member, Zaner, Richard M., Editorial Board Member, Yoshimi, Jeff, editor, Walsh, Philip, editor, and Londen, Patrick, editor

Published
2023
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13. Preface

Author

Harrison, Rebecca L.

Published
2023

16. The Infant KIdney Dialysis and Utrafiltration (I-KID) Study: A Stepped-Wedge Cluster-Randomized Study in Infants, Comparing Peritoneal Dialysis, Continuous Venovenous Hemofiltration, and Newcastle Infant Dialysis Ultrafiltration System, a Novel Infant Hemodialysis Device

Author

Lambert, Heather, Hiu, Shaun, Coulthard, Malcolm G., Matthews, John N. S., Holstein, Eva-Maria, Crosier, Jean, Agbeko, Rachel, Brick, Thomas, Duncan, Heather, Grant, David, Mok, Quen, Nyman, Andrew Gustaf, Pappachan, John, Boucher, Chris, Bulmer, Joe, Chisholm, Denise, Cromie, Kirsten, Emmet, Victoria, Feltbower, Richard G., Ghose, Arunoday, Grayling, Michael, Harrison, Rebecca, Kennedy, Ciara A., McColl, Elaine, Morris, Kevin, Norman, Lee, Office, Julie, Parslow, Roger, Pattinson, Christine, Sharma, Shriya, Smith, Jonathan, Steel, Alison, Steel, Rachel, Straker, Jayne, Vrana, Lamprini, Walker, Jenn, Wellman, Paul, Whitaker, Mike, Wightman, Jim, Wilson, Nina, Wirz, Lucy, and Wood, Ruth

Published
2023
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18. The need for more inclusive deliberation on ethics and governance in agricultural and food biotechnology

Author

Kendig, Catherine, primary, Selfa, Theresa, additional, Thompson, Paul B., additional, Anthony, Raymond, additional, Bauchspies, Wenda, additional, Blue, Gwendolyn, additional, Das, Ashmita, additional, Harrison, Rebecca, additional, Henke, Chris, additional, Jin, Shan, additional, Kuzma, Jennifer, additional, Lipschitz, Forbes, additional, Richter, Kurt, additional, Ruelle, Morgan, additional, Silberg, Timothy, additional, and Takahashi, Bruno, additional

Published
2024
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20. Patient and health-care provider experience of a person-centred, multidisciplinary, psychosocial support and harm reduction programme for patients with harmful use of alcohol and drug-resistant tuberculosis in Minsk, Belarus

Author

Harrison, Rebecca Elizabeth, Shyleika, Volha, Falkenstein, Christian, Garsevanidze, Ekaterine, Vishnevskaya, Olga, Lonnroth, Knut, Sayakci, Öznur, Sinha, Animesh, Sitali, Norman, Skrahina, Alena, Stringer, Beverley, Tan, Cecilio, Mar, Htay Thet, Venis, Sarah, Vetushko, Dmitri, Viney, Kerri, Vishneuski, Raman, and Carrion Martin, Antonio Isidro

Published
2022
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22. ONC201 (Dordaviprone) in Recurrent H3 K27M–Mutant Diffuse Midline Glioma

Author

Arrillaga-Romany, Isabel, primary, Gardner, Sharon L., additional, Odia, Yazmin, additional, Aguilera, Dolly, additional, Allen, Joshua E., additional, Batchelor, Tracy, additional, Butowski, Nicholas, additional, Chen, Clark, additional, Cloughesy, Timothy, additional, Cluster, Andrew, additional, de Groot, John, additional, Dixit, Karan S., additional, Graber, Jerome J., additional, Haggiagi, Aya M., additional, Harrison, Rebecca A., additional, Kheradpour, Albert, additional, Kilburn, Lindsay B., additional, Kurz, Sylvia C., additional, Lu, Guangrong, additional, MacDonald, Tobey J., additional, Mehta, Minesh, additional, Melemed, Allen S., additional, Nghiemphu, Phioanh Leia, additional, Ramage, Samuel C., additional, Shonka, Nicole, additional, Sumrall, Ashley, additional, Tarapore, Rohinton S., additional, Taylor, Lynne, additional, Umemura, Yoshie, additional, and Wen, Patrick Y., additional

Published
2024
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29. Table S4 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

Author

Venneti, Sriram, primary, Kawakibi, Abed Rahman, primary, Ji, Sunjong, primary, Waszak, Sebastian M., primary, Sweha, Stefan R., primary, Mota, Mateus, primary, Pun, Matthew, primary, Deogharkar, Akash, primary, Chung, Chan, primary, Tarapore, Rohinton S., primary, Ramage, Samuel, primary, Chi, Andrew, primary, Wen, Patrick Y., primary, Arrillaga-Romany, Isabel, primary, Batchelor, Tracy T., primary, Butowski, Nicholas A., primary, Sumrall, Ashley, primary, Shonka, Nicole, primary, Harrison, Rebecca A., primary, de Groot, John, primary, Mehta, Minesh, primary, Hall, Matthew D., primary, Daghistani, Doured, primary, Cloughesy, Timothy F., primary, Ellingson, Benjamin M., primary, Beccaria, Kevin, primary, Varlet, Pascale, primary, Kim, Michelle M., primary, Umemura, Yoshie, primary, Garton, Hugh, primary, Franson, Andrea, primary, Schwartz, Jonathan, primary, Jain, Rajan, primary, Kachman, Maureen, primary, Baum, Heidi, primary, Burant, Charles F., primary, Mottl, Sophie L., primary, Cartaxo, Rodrigo T., primary, John, Vishal, primary, Messinger, Dana, primary, Qin, Tingting, primary, Peterson, Erik, primary, Sajjakulnukit, Peter, primary, Ravi, Karthik, primary, Waugh, Alyssa, primary, Walling, Dustin, primary, Ding, Yujie, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Hawes, Debra, primary, Yang, Fusheng, primary, Judkins, Alexander R., primary, Wahl, Daniel, primary, Lyssiotis, Costas A., primary, de la Nava, Daniel, primary, Alonso, Marta M., primary, Eze, Augustine, primary, Spitzer, Jasper, primary, Schmidt, Susanne V., primary, Duchatel, Ryan J., primary, Dun, Matthew D., primary, Cain, Jason E., primary, Jiang, Li, primary, Stopka, Sylwia A., primary, Baquer, Gerard, primary, Regan, Michael S., primary, Filbin, Mariella G., primary, Agar, Nathalie Y.R., primary, Zhao, Lili, primary, Kumar-Sinha, Chandan, primary, Mody, Rajen, primary, Chinnaiyan, Arul, primary, Kurokawa, Ryo, primary, Pratt, Drew, primary, Yadav, Viveka N., primary, Grill, Jacques, primary, Kline, Cassie, primary, Mueller, Sabine, primary, Resnick, Adam, primary, Nazarian, Javad, primary, Allen, Joshua E., primary, Odia, Yazmin, primary, Gardner, Sharon L., primary, and Koschmann, Carl, primary

Published
2023
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30. INNV-35. IMPLEMENTATION OF A NATIONAL ADOLESCENT AND YOUNG ADULT MOLECULAR TUMOR BOARD: REPORT FROM THE CANADIAN AYA NEURO-ONCOLOGY NETWORK

Author

Lim-Fat, Mary-Jane, primary, Das, Sunit, additional, Climans, Seth, additional, MacDonald, Maria, additional, Perreault, Sébastien, additional, Yip, Stephen, additional, Harrison, Rebecca, additional, Lapointe, Sarah, additional, Chan, Aimee, additional, Massey, Natalie, additional, Erker, Craig, additional, MacNeil, Mary, additional, Ironside, Sarah, additional, Tsang, Derek, additional, Hawkins, Cynthia, additional, Tabori, Uri, additional, and Bennett, Julie, additional

Published
2023
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31. Supplementary Figures 1-15 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

Author

Venneti, Sriram, primary, Kawakibi, Abed Rahman, primary, Ji, Sunjong, primary, Waszak, Sebastian M., primary, Sweha, Stefan R., primary, Mota, Mateus, primary, Pun, Matthew, primary, Deogharkar, Akash, primary, Chung, Chan, primary, Tarapore, Rohinton S., primary, Ramage, Samuel, primary, Chi, Andrew, primary, Wen, Patrick Y., primary, Arrillaga-Romany, Isabel, primary, Batchelor, Tracy T., primary, Butowski, Nicholas A., primary, Sumrall, Ashley, primary, Shonka, Nicole, primary, Harrison, Rebecca A., primary, de Groot, John, primary, Mehta, Minesh, primary, Hall, Matthew D., primary, Daghistani, Doured, primary, Cloughesy, Timothy F., primary, Ellingson, Benjamin M., primary, Beccaria, Kevin, primary, Varlet, Pascale, primary, Kim, Michelle M., primary, Umemura, Yoshie, primary, Garton, Hugh, primary, Franson, Andrea, primary, Schwartz, Jonathan, primary, Jain, Rajan, primary, Kachman, Maureen, primary, Baum, Heidi, primary, Burant, Charles F., primary, Mottl, Sophie L., primary, Cartaxo, Rodrigo T., primary, John, Vishal, primary, Messinger, Dana, primary, Qin, Tingting, primary, Peterson, Erik, primary, Sajjakulnukit, Peter, primary, Ravi, Karthik, primary, Waugh, Alyssa, primary, Walling, Dustin, primary, Ding, Yujie, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Hawes, Debra, primary, Yang, Fusheng, primary, Judkins, Alexander R., primary, Wahl, Daniel, primary, Lyssiotis, Costas A., primary, de la Nava, Daniel, primary, Alonso, Marta M., primary, Eze, Augustine, primary, Spitzer, Jasper, primary, Schmidt, Susanne V., primary, Duchatel, Ryan J., primary, Dun, Matthew D., primary, Cain, Jason E., primary, Jiang, Li, primary, Stopka, Sylwia A., primary, Baquer, Gerard, primary, Regan, Michael S., primary, Filbin, Mariella G., primary, Agar, Nathalie Y.R., primary, Zhao, Lili, primary, Kumar-Sinha, Chandan, primary, Mody, Rajen, primary, Chinnaiyan, Arul, primary, Kurokawa, Ryo, primary, Pratt, Drew, primary, Yadav, Viveka N., primary, Grill, Jacques, primary, Kline, Cassie, primary, Mueller, Sabine, primary, Resnick, Adam, primary, Nazarian, Javad, primary, Allen, Joshua E., primary, Odia, Yazmin, primary, Gardner, Sharon L., primary, and Koschmann, Carl, primary

Published
2023
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32. Supplementary Data S2 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

Author

Venneti, Sriram, primary, Kawakibi, Abed Rahman, primary, Ji, Sunjong, primary, Waszak, Sebastian M., primary, Sweha, Stefan R., primary, Mota, Mateus, primary, Pun, Matthew, primary, Deogharkar, Akash, primary, Chung, Chan, primary, Tarapore, Rohinton S., primary, Ramage, Samuel, primary, Chi, Andrew, primary, Wen, Patrick Y., primary, Arrillaga-Romany, Isabel, primary, Batchelor, Tracy T., primary, Butowski, Nicholas A., primary, Sumrall, Ashley, primary, Shonka, Nicole, primary, Harrison, Rebecca A., primary, de Groot, John, primary, Mehta, Minesh, primary, Hall, Matthew D., primary, Daghistani, Doured, primary, Cloughesy, Timothy F., primary, Ellingson, Benjamin M., primary, Beccaria, Kevin, primary, Varlet, Pascale, primary, Kim, Michelle M., primary, Umemura, Yoshie, primary, Garton, Hugh, primary, Franson, Andrea, primary, Schwartz, Jonathan, primary, Jain, Rajan, primary, Kachman, Maureen, primary, Baum, Heidi, primary, Burant, Charles F., primary, Mottl, Sophie L., primary, Cartaxo, Rodrigo T., primary, John, Vishal, primary, Messinger, Dana, primary, Qin, Tingting, primary, Peterson, Erik, primary, Sajjakulnukit, Peter, primary, Ravi, Karthik, primary, Waugh, Alyssa, primary, Walling, Dustin, primary, Ding, Yujie, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Hawes, Debra, primary, Yang, Fusheng, primary, Judkins, Alexander R., primary, Wahl, Daniel, primary, Lyssiotis, Costas A., primary, de la Nava, Daniel, primary, Alonso, Marta M., primary, Eze, Augustine, primary, Spitzer, Jasper, primary, Schmidt, Susanne V., primary, Duchatel, Ryan J., primary, Dun, Matthew D., primary, Cain, Jason E., primary, Jiang, Li, primary, Stopka, Sylwia A., primary, Baquer, Gerard, primary, Regan, Michael S., primary, Filbin, Mariella G., primary, Agar, Nathalie Y.R., primary, Zhao, Lili, primary, Kumar-Sinha, Chandan, primary, Mody, Rajen, primary, Chinnaiyan, Arul, primary, Kurokawa, Ryo, primary, Pratt, Drew, primary, Yadav, Viveka N., primary, Grill, Jacques, primary, Kline, Cassie, primary, Mueller, Sabine, primary, Resnick, Adam, primary, Nazarian, Javad, primary, Allen, Joshua E., primary, Odia, Yazmin, primary, Gardner, Sharon L., primary, and Koschmann, Carl, primary

Published
2023
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33. Data from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

Author

Venneti, Sriram, primary, Kawakibi, Abed Rahman, primary, Ji, Sunjong, primary, Waszak, Sebastian M., primary, Sweha, Stefan R., primary, Mota, Mateus, primary, Pun, Matthew, primary, Deogharkar, Akash, primary, Chung, Chan, primary, Tarapore, Rohinton S., primary, Ramage, Samuel, primary, Chi, Andrew, primary, Wen, Patrick Y., primary, Arrillaga-Romany, Isabel, primary, Batchelor, Tracy T., primary, Butowski, Nicholas A., primary, Sumrall, Ashley, primary, Shonka, Nicole, primary, Harrison, Rebecca A., primary, de Groot, John, primary, Mehta, Minesh, primary, Hall, Matthew D., primary, Daghistani, Doured, primary, Cloughesy, Timothy F., primary, Ellingson, Benjamin M., primary, Beccaria, Kevin, primary, Varlet, Pascale, primary, Kim, Michelle M., primary, Umemura, Yoshie, primary, Garton, Hugh, primary, Franson, Andrea, primary, Schwartz, Jonathan, primary, Jain, Rajan, primary, Kachman, Maureen, primary, Baum, Heidi, primary, Burant, Charles F., primary, Mottl, Sophie L., primary, Cartaxo, Rodrigo T., primary, John, Vishal, primary, Messinger, Dana, primary, Qin, Tingting, primary, Peterson, Erik, primary, Sajjakulnukit, Peter, primary, Ravi, Karthik, primary, Waugh, Alyssa, primary, Walling, Dustin, primary, Ding, Yujie, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Hawes, Debra, primary, Yang, Fusheng, primary, Judkins, Alexander R., primary, Wahl, Daniel, primary, Lyssiotis, Costas A., primary, de la Nava, Daniel, primary, Alonso, Marta M., primary, Eze, Augustine, primary, Spitzer, Jasper, primary, Schmidt, Susanne V., primary, Duchatel, Ryan J., primary, Dun, Matthew D., primary, Cain, Jason E., primary, Jiang, Li, primary, Stopka, Sylwia A., primary, Baquer, Gerard, primary, Regan, Michael S., primary, Filbin, Mariella G., primary, Agar, Nathalie Y.R., primary, Zhao, Lili, primary, Kumar-Sinha, Chandan, primary, Mody, Rajen, primary, Chinnaiyan, Arul, primary, Kurokawa, Ryo, primary, Pratt, Drew, primary, Yadav, Viveka N., primary, Grill, Jacques, primary, Kline, Cassie, primary, Mueller, Sabine, primary, Resnick, Adam, primary, Nazarian, Javad, primary, Allen, Joshua E., primary, Odia, Yazmin, primary, Gardner, Sharon L., primary, and Koschmann, Carl, primary

Published
2023
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35. Characterization of patients with brain metastases referred to palliative care.

Author

Harrison, Rebecca A., Tang, Michael, Shih, Kaoswi Karina, Khan, Maria, Pham, Lily, De Moraes, Aline Rozman, O'Brien, Barbara J., Bassett, Roland, and Bruera, Eduardo

Subjects
*BRAIN tumor treatment, *INTENSIVE care units, *CONFIDENCE intervals, *MELANOMA, *METASTASIS, *RETROSPECTIVE studies, *PATIENTS, *LUNG tumors, *TREATMENT effectiveness, *HOSPITAL admission & discharge, *SYMPTOMS, *MEDICAL referrals, *KAPLAN-Meier estimator, *HOSPITAL care, *DESCRIPTIVE statistics, *RESEARCH funding, *DATA analysis software, *PALLIATIVE treatment, *EMERGENCY room visits, *BREAST tumors
Abstract

Purpose: In this study, we aimed to assess the clinical characteristics, reasons for referral, and outcomes of patients with brain metastases (BM) referred to the supportive care center. Methods: Equal numbers of patients with melanoma, breast cancer, and lung cancer with (N = 90) and without (N = 90) BM were retrospectively identified from the supportive care database for study. Descriptive statistics were used to analyze demographic, disease, and clinical data. Kaplan Meier method was used to evaluate survival outcomes. Results: While physical symptom management was the most common reason for referral to supportive care for both patients with and without BM, patients with BM had significantly lower pain scores on ESAS at time of referral (p = 0.002). They had greater interaction with acute care in the last weeks of life, with higher rates of ICU admission, emergency room visits, and hospitalizations after initial supportive care (SC) visit. The median survival time from referral to Supportive Care Center (SCC) was 0.90 years (95% CI 0.73, 1.40) for the brain metastasis group and 1.29 years (95% CI 0.91, 2.29) for the group without BM. Conclusions: Patients with BM have shorter survival and greater interaction with acute care in the last weeks of life. This population also has distinct symptom burdens from patients without BM. Strategies to optimize integration of SC for patients with BM warrant ongoing study. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

Author

Venneti, Sriram, primary, Kawakibi, Abed Rahman, additional, Ji, Sunjong, additional, Waszak, Sebastian M., additional, Sweha, Stefan R., additional, Mota, Mateus, additional, Pun, Matthew, additional, Deogharkar, Akash, additional, Chung, Chan, additional, Tarapore, Rohinton S., additional, Ramage, Samuel, additional, Chi, Andrew, additional, Wen, Patrick Y., additional, Arrillaga-Romany, Isabel, additional, Batchelor, Tracy T., additional, Butowski, Nicholas A., additional, Sumrall, Ashley, additional, Shonka, Nicole, additional, Harrison, Rebecca A., additional, de Groot, John, additional, Mehta, Minesh, additional, Hall, Matthew D., additional, Daghistani, Doured, additional, Cloughesy, Timothy F., additional, Ellingson, Benjamin M., additional, Beccaria, Kevin, additional, Varlet, Pascale, additional, Kim, Michelle M., additional, Umemura, Yoshie, additional, Garton, Hugh, additional, Franson, Andrea, additional, Schwartz, Jonathan, additional, Jain, Rajan, additional, Kachman, Maureen, additional, Baum, Heidi, additional, Burant, Charles F., additional, Mottl, Sophie L., additional, Cartaxo, Rodrigo T., additional, John, Vishal, additional, Messinger, Dana, additional, Qin, Tingting, additional, Peterson, Erik, additional, Sajjakulnukit, Peter, additional, Ravi, Karthik, additional, Waugh, Alyssa, additional, Walling, Dustin, additional, Ding, Yujie, additional, Xia, Ziyun, additional, Schwendeman, Anna, additional, Hawes, Debra, additional, Yang, Fusheng, additional, Judkins, Alexander R., additional, Wahl, Daniel, additional, Lyssiotis, Costas A., additional, de la Nava, Daniel, additional, Alonso, Marta M., additional, Eze, Augustine, additional, Spitzer, Jasper, additional, Schmidt, Susanne V., additional, Duchatel, Ryan J., additional, Dun, Matthew D., additional, Cain, Jason E., additional, Jiang, Li, additional, Stopka, Sylwia A., additional, Baquer, Gerard, additional, Regan, Michael S., additional, Filbin, Mariella G., additional, Agar, Nathalie Y.R., additional, Zhao, Lili, additional, Kumar-Sinha, Chandan, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Kurokawa, Ryo, additional, Pratt, Drew, additional, Yadav, Viveka N., additional, Grill, Jacques, additional, Kline, Cassie, additional, Mueller, Sabine, additional, Resnick, Adam, additional, Nazarian, Javad, additional, Allen, Joshua E., additional, Odia, Yazmin, additional, Gardner, Sharon L., additional, and Koschmann, Carl, additional

Published
2023
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38. Impact of the government's restrictions and guidance in relation to 'social distancing' on the lives of ethnic minority populations:A mixed methods study

Author

Saini, Pooja, Porcellato, Lorna, Hunt, Anna, Timpson, Hannah, Harrison, Rebecca, Bigland, Charlotte, Levy, Conan, Brett, Caroline E., Forshaw, Mark, Hope, Vivian, and Team, The Phoenix

Subjects
Covid‐19, ethnic minority, social distancing, government restrictions
Abstract

Background and AimsThe impacts of the COVID-19 pandemic have not been equal, with a disproportionate impact among ethnic minority communities. Structural inequalities in social determinants of health such as housing and employment have contributed to COVID-19's impact on deprived communities, including many ethnic minority communities. To compare (1) how the UK government's “social distancing” restrictions and guidance were perceived and implemented by ethnic minority populations compared to white populations, (2) the impact of restrictions and guidance upon these groups.MethodsAn explanatory sequential mixed methods study incorporated a quantitative survey and qualitative semi-structured interviews to explore individual perceptions and experiences of COVID-19 and the national restrictions. Survey participants (n = 1587) were recruited from North West England; 60 (4%) participants were from ethnic minority communities. Forty-nine interviews were conducted; 19 (39%) participants were from ethnic minority communities. Interviews were transcribed verbatim and analysed using a thematic approach. Data collection was between April and August 2020.ResultsSignificant differences in demographics and household overcrowding were observed between white vs ethnic minority survey respondents, who were also significantly less confident in their knowledge of COVID-19, less likely to be high-risk drinkers, and marginally more likely to have experienced job loss and/or reduced household income. There were no group differences in wellbeing, perceptions, or nonfinancial impacts. Two inter-related themes included: (1) government guidance, incorporating people's knowledge and understanding of the guidance and their confusion/frustration over messaging; (2) the impacts of restrictions on keyworkers, home-schooling, working from home and changes in lifestyle/wellbeing.ConclusionsFurther research is needed on the long-term impacts of COVID-19 on ethnic minority communities. If policy responses to COVID-19 are to benefit ethnic minority communities, there is a need for future studies to consider fundamental societal issues, such as the role of housing and economic disadvantage.

Published
2023

41. Abstract LB127: VAL-083 in patients with recurrent glioblastoma treated under expanded access program

Author

Kamiya-Matsuoka, Carlos, primary, Weathers, Shiao-Pei, additional, Harrison, Rebecca A., additional, Majd, Nazanin K., additional, Aaroe, Ashley E., additional, Knight, Stephanie, additional, Hanna, Teresa, additional, Gregory, Timothy A., additional, Langlands, John, additional, Brown, Dennis, additional, and Puduvalli, Vinay K., additional

Published
2023
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42. Supplementary Figure 4 from Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial

Author

Weathers, Shiao-Pei, primary, Penas-Prado, Marta, primary, Pei, Be-Lian, primary, Ling, Xiaoyang, primary, Kassab, Cynthia, primary, Banerjee, Pinaki, primary, Bdiwi, Mustafa, primary, Shaim, Hila, primary, Alsuliman, Abdullah, primary, Shanley, Mayra, primary, de Groot, John F., primary, O'Brien, Barbara J., primary, Harrison, Rebecca, primary, Majd, Nazanin, primary, Kamiya-Matsuoka, Carlos, primary, Fuller, Gregory N., primary, Huse, Jason T., primary, Chi, Linda, primary, Rao, Ganesh, primary, Weinberg, Jeffrey S., primary, Lang, Frederick F., primary, Sawaya, Raymond, primary, Shpall, Elizabeth J., primary, Rezvani, Katayoun, primary, and Heimberger, Amy B., primary

Published
2023
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43. Supplementary Figure 3 from Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial

Author

Weathers, Shiao-Pei, primary, Penas-Prado, Marta, primary, Pei, Be-Lian, primary, Ling, Xiaoyang, primary, Kassab, Cynthia, primary, Banerjee, Pinaki, primary, Bdiwi, Mustafa, primary, Shaim, Hila, primary, Alsuliman, Abdullah, primary, Shanley, Mayra, primary, de Groot, John F., primary, O'Brien, Barbara J., primary, Harrison, Rebecca, primary, Majd, Nazanin, primary, Kamiya-Matsuoka, Carlos, primary, Fuller, Gregory N., primary, Huse, Jason T., primary, Chi, Linda, primary, Rao, Ganesh, primary, Weinberg, Jeffrey S., primary, Lang, Frederick F., primary, Sawaya, Raymond, primary, Shpall, Elizabeth J., primary, Rezvani, Katayoun, primary, and Heimberger, Amy B., primary

Published
2023
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44. Supplementary Figure 1 from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo

Author

Milicic, Anita, primary, Harrison, Lea-Anne, primary, Goodlad, Robert A., primary, Hardy, Robert G., primary, Nicholson, Anna M., primary, Presz, Michal, primary, Sieber, Oliver, primary, Santander, Sonia, primary, Pringle, James H., primary, Mandir, Nikki, primary, East, Philip, primary, Obszynska, Jolanta, primary, Sanders, Scott, primary, Piazuelo, Elena, primary, Shaw, Jacqui, primary, Harrison, Rebecca, primary, Tomlinson, Ian P., primary, McDonald, Stuart A.C., primary, Wright, Nicholas A., primary, and Jankowski, Janusz A.Z., primary

Published
2023
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45. Data from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo

Author

Milicic, Anita, primary, Harrison, Lea-Anne, primary, Goodlad, Robert A., primary, Hardy, Robert G., primary, Nicholson, Anna M., primary, Presz, Michal, primary, Sieber, Oliver, primary, Santander, Sonia, primary, Pringle, James H., primary, Mandir, Nikki, primary, East, Philip, primary, Obszynska, Jolanta, primary, Sanders, Scott, primary, Piazuelo, Elena, primary, Shaw, Jacqui, primary, Harrison, Rebecca, primary, Tomlinson, Ian P., primary, McDonald, Stuart A.C., primary, Wright, Nicholas A., primary, and Jankowski, Janusz A.Z., primary

Published
2023
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46. Supplementary Figure 2 from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo

Author

Milicic, Anita, primary, Harrison, Lea-Anne, primary, Goodlad, Robert A., primary, Hardy, Robert G., primary, Nicholson, Anna M., primary, Presz, Michal, primary, Sieber, Oliver, primary, Santander, Sonia, primary, Pringle, James H., primary, Mandir, Nikki, primary, East, Philip, primary, Obszynska, Jolanta, primary, Sanders, Scott, primary, Piazuelo, Elena, primary, Shaw, Jacqui, primary, Harrison, Rebecca, primary, Tomlinson, Ian P., primary, McDonald, Stuart A.C., primary, Wright, Nicholas A., primary, and Jankowski, Janusz A.Z., primary

Published
2023
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47. Supplementary Materials from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo

Author

Milicic, Anita, primary, Harrison, Lea-Anne, primary, Goodlad, Robert A., primary, Hardy, Robert G., primary, Nicholson, Anna M., primary, Presz, Michal, primary, Sieber, Oliver, primary, Santander, Sonia, primary, Pringle, James H., primary, Mandir, Nikki, primary, East, Philip, primary, Obszynska, Jolanta, primary, Sanders, Scott, primary, Piazuelo, Elena, primary, Shaw, Jacqui, primary, Harrison, Rebecca, primary, Tomlinson, Ian P., primary, McDonald, Stuart A.C., primary, Wright, Nicholas A., primary, and Jankowski, Janusz A.Z., primary

Published
2023
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48. Poor outcomes among critically ill HIV-positive patients at hospital discharge and post-discharge in Guinea, Conakry: A retrospective cohort study

Author

Albus, Sebastian Ludwig, primary, Harrison, Rebecca E., additional, Moudachirou, Ramzia, additional, Nanan-N’Zeth, Kassi, additional, Haba, Benoit, additional, Casas, Esther C., additional, Isaakidis, Petros, additional, Diallo, Abdourahimi, additional, Camara, Issiaga, additional, Doumbuya, Marie, additional, Sako, Fode Bangaly, additional, and Cisse, Mohammed, additional

Published
2023
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50. Telephone networks and transactional motherhood in Channel 4’s It’s A Sin

Author

Harrison, Rebecca

Subjects
Cultural Studies, Arts and Humanities (miscellaneous), Education
Abstract

This article offers an analysis of women’s representation in the 2021 Channel 4 series It’s A Sin. Focusing on the show’s narrative and ideological use of the telephone network as a system of transactional care, the article critiques depictions of motherhood and questions the erasure of narratives about experiences of gender, race, sexuality, class and disability in queer communities. By way of textual analysis and histories of communication technologies in the 1980s and 1990s, the article argues that It’s A Sin perpetuates conservative and moralising perspectives on a range of issues, particularly with regard to gender and sexual activity.

Published
2022

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