Search

Your search keyword '"Habermann, Jens"' showing total 23 results
Start Over Author "Habermann, Jens" Publication Year Range Last 3 years
23 results on '"Habermann, Jens"'

3. What public health challenges and unmet medical needs would benefit from interdisciplinary collaboration in the EU? A survey and multi-stakeholder debate.

Author

Pistollato, Francesca, Burkhart, Gregor, Deceuninck, Pierre, Bernasconi, Camilla, Di Virgilio, Sergio, Emili, Luca, Fauvel, Anne-Charlotte, Ferreira Bastos, Luisa, Gastaldello, Annalisa, Gerardi, Chiara, Habermann, Jens K., Hanes, Ioan, Kyriakopoulou, Christina, Lanka, Uma, Lauriola, Paolo, Laverty, Hugh, Maisonneuve, Benoit G. C., Mennecozzi, Milena, Pappalardo, Francesco, and Pastorino, Roberta

Published
2024
Full Text
View/download PDF

4. Effect of volume flows on the viability of MSCs during injection through a cannula

Author

Nießen Lina, Facchinetti Giulia, Elsner Till, Wendlandt Robert, Gemoll Timo, Habermann Jens K., and Schulz Arndt-Peter

Subjects
mesenchymal stem cells, cell viability, nonunion, volume flows, shear forces, Medicine
Abstract

Introduction: Clinical trials currently evaluate the use of mesenchymal stem cells (MSCs) for the treatment of non-union bone fractures. The stem cells are injected directly into the non-union area of a bone via a cannula. During this injection process, pressure and shear forces affect the MSCs which could influence the viability of the cells. One parameter that influences the level of the shear forces is the volume flow. The aim of this study is to show whether the injection process with two different volume flows influences the cell viability. Methods: MSCs were isolated from bone tissue, harvested during arthroplasty. Afterwards, they were diluted to a concentration of 1 million cells/mL and 1 mL of this suspension was injected through a cannula with 200 mm length and 2 mm diameter (14 G) with volume flows of 38 and 100 mL/min. The evaluation was performed by detecting living, apoptotic, and dead cells using flow cytometry. The statistical analysis was performed with a Kruskal-Wallis-test to identify significant differences and with a TOST procedure for significant equivalence. The significance level was set to 5 % and the equivalence margin to 20 %. Results: The cell population of healthy cells was in the control group 85.88±2.98 %. After an injection with 38 mL/min the population of healthy cells was 86.04±2.53 % and with 100 ml/min 85.48±1.64 %. The statistical analysis revealed no significant difference between these groups (p = 0.99), but a significant equivalence between the control group and the two volume flows (38 mL/min: p = 0.002, 100 mL/min: p = 0.001). In addition the results show no increase of apoptotic and dead cells in the population after injection. Conclusion: The results indicate that the injection process through the cannula with these volume flows has no effect on the viability of the MSCs.

Published
2021
Full Text
View/download PDF

5. biobank.cy: The Biobank of Cyprus past, present and future

Author

Loizidou, Eleni M., primary, Kyratzi, Maria, additional, Tsiarli, Maria A., additional, Kakouri, Andrea C., additional, Charalambidou, Georgia, additional, Antoniou, Stella, additional, Pieri, Stylianos, additional, Veloudi, Panagiota, additional, Mayrhofer, Michaela Th., additional, Wutte, Andrea, additional, Kozera, Lukasz, additional, Habermann, Jens, additional, Muller, Heimo, additional, Zatloukal, Kurt, additional, Sargsyan, Karine, additional, Michaelides, Alexandros, additional, Papaioannou, Maria, additional, Schizas, Christos, additional, Malatras, Apostolos, additional, Papagregoriou, Gregory, additional, and Deltas, Constantinos, additional

Published
2024
Full Text
View/download PDF

6. Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies

Author

Patkar, Sushant, Heselmeyer-Haddad, Kerstin, Auslander, Noam, Hirsch, Daniela, Camps, Jordi, Bronder, Daniel, Brown, Markus, Chen, Wei-Dong, Lokanga, Rachel, Wangsa, Darawalee, Wangsa, Danny, Hu, Yue, Lischka, Annette, Braun, Rüdiger, Emons, Georg, Ghadimi, B. Michael, Gaedcke, Jochen, Grade, Marian, Montagna, Cristina, Lazebnik, Yuri, Difilippantonio, Michael J., Habermann, Jens K., Auer, Gert, Ruppin, Eytan, and Ried, Thomas

Published
2021
Full Text
View/download PDF

8. Supplementary Text from Single-Cell–Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response

Author

Braun, Rüdiger, primary, Anthuber, Lena, primary, Hirsch, Daniela, primary, Wangsa, Darawalee, primary, Lack, Justin, primary, McNeil, Nicole E., primary, Heselmeyer-Haddad, Kerstin, primary, Torres, Irianna, primary, Wangsa, Danny, primary, Brown, Markus A., primary, Tubbs, Anthony, primary, Auslander, Noam, primary, Gertz, E. Michael, primary, Brauer, Philip R., primary, Cam, Margaret C., primary, Sackett, Dan L., primary, Habermann, Jens K., primary, Nussenzweig, Andre, primary, Ruppin, Eytan, primary, Zhang, Zhongqiu, primary, Rosenberg, Daniel W., primary, and Ried, Thomas, primary

Published
2023
Full Text
View/download PDF

9. Figure S7 from Single-Cell–Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response

Author

Braun, Rüdiger, primary, Anthuber, Lena, primary, Hirsch, Daniela, primary, Wangsa, Darawalee, primary, Lack, Justin, primary, McNeil, Nicole E., primary, Heselmeyer-Haddad, Kerstin, primary, Torres, Irianna, primary, Wangsa, Danny, primary, Brown, Markus A., primary, Tubbs, Anthony, primary, Auslander, Noam, primary, Gertz, E. Michael, primary, Brauer, Philip R., primary, Cam, Margaret C., primary, Sackett, Dan L., primary, Habermann, Jens K., primary, Nussenzweig, Andre, primary, Ruppin, Eytan, primary, Zhang, Zhongqiu, primary, Rosenberg, Daniel W., primary, and Ried, Thomas, primary

Published
2023
Full Text
View/download PDF

11. Data from Single-Cell–Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response

Author

Braun, Rüdiger, primary, Anthuber, Lena, primary, Hirsch, Daniela, primary, Wangsa, Darawalee, primary, Lack, Justin, primary, McNeil, Nicole E., primary, Heselmeyer-Haddad, Kerstin, primary, Torres, Irianna, primary, Wangsa, Danny, primary, Brown, Markus A., primary, Tubbs, Anthony, primary, Auslander, Noam, primary, Gertz, E. Michael, primary, Brauer, Philip R., primary, Cam, Margaret C., primary, Sackett, Dan L., primary, Habermann, Jens K., primary, Nussenzweig, Andre, primary, Ruppin, Eytan, primary, Zhang, Zhongqiu, primary, Rosenberg, Daniel W., primary, and Ried, Thomas, primary

Published
2023
Full Text
View/download PDF

20. Tumor cell E-selectin ligands determine partialefficacy of bortezomib on spontaneous lung metastasis formation of solid human tumors in vivo

Author

Lange, Tobias, primary, Valentiner, Ursula, additional, Wicklein, Daniel, additional, Maar, Hanna, additional, Labitzky, Vera, additional, Ahlers, Ann-Kristin, additional, Starzonek, Sarah, additional, Genduso, Sandra, additional, Staffeldt, Lisa, additional, Pahlow, Carolin, additional, Dück, Anna-Maria, additional, Stürken, Christine, additional, Baranowsky, Anke, additional, Bauer, Alexander T., additional, Bulk, Etmar, additional, Schwab, Albrecht, additional, Riecken, Kristoffer, additional, Börnchen, Christian, additional, Kiefmann, Rainer, additional, Abraham, Valsamma, additional, DeLisser, Horace M., additional, Gemoll, Timo, additional, Habermann, Jens K., additional, Block, Andreas, additional, Pantel, Klaus, additional, and Schumacher, Udo, additional

Published
2022
Full Text
View/download PDF

21. Protein Expression of AEBP1, MCM4, and FABP4 Differentiate Osteogenic, Adipogenic, and Mesenchymal Stromal Stem Cells

Author

Sauer, Thorben, primary, Facchinetti, Giulia, additional, Kohl, Michael, additional, Kowal, Justyna M., additional, Rozanova, Svitlana, additional, Horn, Julia, additional, Schmal, Hagen, additional, Kwee, Ivo, additional, Schulz, Arndt-Peter, additional, Hartwig, Sonja, additional, Kassem, Moustapha, additional, Habermann, Jens K., additional, and Gemoll, Timo, additional

Published
2022
Full Text
View/download PDF

22. Tumor cell E-selectin ligands determine partial inhibitory efficacy of bortezomib on spontaneous lung metastasis formation of solid human tumors in vivo

Author

Lange, Tobias, Valentiner, Ursula, Wicklein, Daniel, Maar, Hanna, Labitzky, Vera, Ahlers, Ann-Kristin, Starzonek, Sarah, Genduso, Sandra, Staffeldt, Lisa, Pahlow, Carolin, Dück, Anna-Maria, Stürken, Christine, Baranowsky, Anke, Bauer, Alexander T., Bulk, Etmar, Schwab, Albrecht, Riecken, Kristoffer, Börnchen, Christian, Kiefmann, Rainer, Abraham, Valsamma, DeLisser, Horace M., Gemoll, Timo, Habermann, Jens K., Block, Andreas, Pantel, Klaus, and Schumacher, Udo

Abstract

Extravasation of circulating tumor cells (CTCs) is critical for metastasis and initiated by adhesive interactions between glycoligands on CTCs and E-selectin on endothelia. Here we show that the clinically approved proteasome inhibitor bortezomib (BZM=Velcade®) counteracts the cytokine-dependent induction of E-selectin in the lung mediated by the primary tumor, thereby impairing endothelial adhesion and thus spontaneous lung metastasis in vivo. However, the efficacy of BZM crucially depends on the tumor cells’ E-selectin ligands, which determine distinct adhesion patterns: The canonical ligands sialyl-Lewis A (sLeA) and sLeX mediate particularly high-affinity E-selectin binding, so that the incomplete E-selectin-reducing effect of BZM is not sufficient to disrupt adhesion or metastasis. In contrast, tumor cells lacking sLeA/X nevertheless bind E-selectin, but with low affinity, so that adhesion and lung metastasis are significantly diminished. Such low-affinity E-selectin ligands apparently consist of sialylated MGAT5 products on CD44. BZM no longer has anti-metastatic activity after CD44 knockdown in sLeA/X-negative tumor cells or E-selectin knockout in mice. sLeA/X can be determined by immunohistochemistry in cancer samples, which might aid patient stratification. These data suggest that BZM might act as a drug for inhibiting extravasation and hence distant metastasis formation in malignancies expressing low affinity E-selectin ligands.

Published
2022
Full Text
View/download PDF

23. UNCAN.eu: Toward a European Federated Cancer Research Data Hub.

Author

Boutros M, Baumann M, Bigas A, Chaabane L, Guérin J, Habermann JK, Jobard A, Pelicci PG, Stegle O, Tonon G, Valencia A, Winkler EC, Blanc P, De Maria R, Medema RH, Nagy P, Tabernero J, and Solary E

Subjects
Humans, Research, European Union, Neoplasms
Abstract

To enable a collective effort that generates a new level of UNderstanding CANcer (UNCAN.eu) [Cancer Discov (2022) 12 (11): OF1], the European Union supports the creation of a sustainable platform that connects cancer research across Member States. A workshop hosted in Heidelberg gathered European cancer experts to identify ongoing initiatives that may contribute to building this platform and discuss the governance and long-term evolution of a European Federated Cancer Data Hub., (©2023 The Authors; Published by the American Association for Cancer Research.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results