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Your search keyword '"Guthrie, Jeffrey"' showing total 18 results
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18 results on '"Guthrie, Jeffrey"'

1. The role of leptin in regulation of the soluble amyloid precursor protein α (sAPPα) levels in lung cancer cell media

Author

Haddad, Ben, primary, Khalil, Jeneen, additional, Al Khashali, Hind, additional, Ray, Ravel, additional, Goel, Stuti, additional, Darweesh, Ban, additional, Coleman, Kai-ling, additional, Wozniak, Caroline, additional, Ranzenberger, Robert, additional, Lopo, Brooke, additional, Guthrie, Jeffrey, additional, Heyl, Deborah, additional, and Evans, Hedeel Guy, additional

Published
2024
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3. Amyloid Beta Leads to Decreased Acetylcholine Levels and Non-Small Cell Lung Cancer Cell Survival via a Mechanism That Involves p38 Mitogen-Activated Protein Kinase and Protein Kinase C in a p53-Dependent and -Independent Manner.

Author

Al Khashali, Hind, Ray, Ravel, Darweesh, Ban, Wozniak, Caroline, Haddad, Ben, Goel, Stuti, Seidu, Issah, Khalil, Jeneen, Lopo, Brooke, Murshed, Nayrooz, Guthrie, Jeffrey, Heyl, Deborah, and Evans, Hedeel Guy

Subjects
NON-small-cell lung carcinoma, MITOGEN-activated protein kinases, CELL survival, AMYLOID, PROTEIN kinase C, ACETYLCHOLINE, ACETYLCHOLINESTERASE, CANCER cells
Abstract

Several studies have shown an inverse correlation between the likelihood of developing a neurodegenerative disorder and cancer. We previously reported that the levels of amyloid beta (Aβ), at the center of Alzheimer's disease pathophysiology, are regulated by acetylcholinesterase (AChE) in non-small cell lung cancer (NSCLC). Here, we examined the effect of Aβ or its fragments on the levels of ACh in A549 (p53 wild-type) and H1299 (p53-null) NSCLC cell media. ACh levels were reduced by cell treatment with Aβ 1–42, Aβ 1–40, Aβ 1–28, and Aβ 25–35. AChE and p53 activities increased upon A549 cell treatment with Aβ, while knockdown of p53 in A549 cells increased ACh levels, decreased AChE activity, and diminished the Aβ effects. Aβ increased the ratio of phospho/total p38 MAPK and decreased the activity of PKC. Inhibiting p38 MAPK reduced the activity of p53 in A549 cells and increased ACh levels in the media of both cell lines, while opposite effects were found upon inhibiting PKC. ACh decreased the activity of p53 in A549 cells, decreased p38 MAPK activity, increased PKC activity, and diminished the effect of Aβ on those activities. Moreover, the negative effect of Aβ on cell viability was diminished by cell co-treatment with ACh. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Regulation of Vascular Endothelial Growth Factor Signaling by Nicotine in a Manner Dependent on Acetylcholine-and/or β-Adrenergic-Receptors in Human Lung Cancer Cells

Author

Al Khashali, Hind, primary, Darweesh, Ban, additional, Ray, Ravel, additional, Haddad, Ben, additional, Wozniak, Caroline, additional, Ranzenberger, Robert, additional, Goel, Stuti, additional, Khalil, Jeneen, additional, Guthrie, Jeffrey, additional, Heyl, Deborah, additional, and Evans, Hedeel Guy, additional

Published
2023
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9. Achieving Tactical and Strategic Synergy in Optimizing Reproductive Health Care for Active-Duty Service Women The Military Active-Duty Reproductive + Sexual Health (MARSH) Research Program & Multiphase Optimization Strategy (MOST)

Author

Department of Family Medicine (FAM), SOM, Ryan Landoll, Sara E. Vargas, Kate M. Guthrie, Jeffrey Quinlan, Madison F. Clark, Francis Obuseh, Amelia Ozemoya, Department of Family Medicine (FAM), SOM, Ryan Landoll, and Sara E. Vargas, Kate M. Guthrie, Jeffrey Quinlan, Madison F. Clark, Francis Obuseh, Amelia Ozemoya

Abstract

Achieving Tactical and Strategic Synergy in Optimizing Reproductive Health Care for Active-Duty Service Women The Military Active-Duty Reproductive + Sexual Health (MARSH) Research Program & Multiphase Optimization Strategy (MOST) Ryan R. Landoll, PhD, ABPP, Lt Col, USAFR, Sara E. Vargas, PhD, Kate M. Guthrie, PhD, Jeffrey Quinlan, MD, Madison F. Clark, BS, Francis Obuseh, DrPH, & Amelia Ozemoya, MHS FUTURE DIRECTIONS RESULTS MULTIPHASE OPTIMIZATION STRATEGY (MOST) THE PROBLEM MARSH RESEARCH PROGRAM (Collins, 2018) The views expressed herein are solely those of the study team individually and are not representative of their respective institutions, to include the Uniformed Services University, Department of Defense or United States Government Focusing on DHA and DoD Priorities Ensuring Local Command Support Listening to Healthcare Providers and Service Members Unintended Pregnancies among U.S. Service Members High-risk Service Members untested for HIV in past year Cities with Military Installations in Top 20 for STIs nationally Think Talking to a Provider about Sexual Health Will be Negative • HIV/STI/Pregnancy Basic Training • Skills-Building Videos Beyond the Basics • Narrative Videos Stories from the Field • Interactive Scenarios Difficult Conversations • Goal Setting My Goals • Behavioral Risk Game Know Your Risk Q&A and Resources App Components • Formed in 2017 in partnership with The Miriam Hospital, affiliated with Brown University • Initially funded by the USU Women’s Health Research Consortium, with data collection endorsed by USD/P&R, employs mixed-method design • Has developed partnerships with 12 tri-service Military Treatment Facilities and over 40 collaborators, leverages civilian, military and academic partnerships • Intentional, data-driven, iterative and scientific approach to dissemination and implementation of sexual health resources “The amount of information available, it's a one stop area for any questions one may have” Needs assessment informe, RITM0040115, N/A

Published
2023

10. Phosphorylation of IGFBP-3 by Casein Kinase 2 Blocks Its Interaction with Hyaluronan, Enabling HA-CD44 Signaling Leading to Increased NSCLC Cell Survival and Cisplatin Resistance

Author

Coleman, Kai-ling, primary, Chiaramonti, Michael, additional, Haddad, Ben, additional, Ranzenberger, Robert, additional, Henning, Heather, additional, Al Khashali, Hind, additional, Ray, Ravel, additional, Darweesh, Ban, additional, Guthrie, Jeffrey, additional, Heyl, Deborah, additional, and Evans, Hedeel Guy, additional

Published
2023
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14. Abstract 1350: Investigating the Role of Acetylcholinesterase and Brain-Derived Neurotrophic Factor in Regulating the Levels of Soluble Amyloid Precursor Protein α (sAPPα) in Lung Cancer Cell Media

Author

Al khashali, Hind, primary, Ray, Ravel, additional, Coleman, Kai-ling, additional, Atali, Sarah, additional, Haddad, Ben, additional, Wareham, Jadziah, additional, Guthrie, Jeffrey, additional, Heyl-Clegg, Deborah, additional, and Evans, Hedeel, additional

Published
2023
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