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Author(s): Meenakshi Kamboj (corresponding author) [1]; Gurudutt Gupta [1]; Sunil Pasricha [1]; Anila Sharma [1]; Garima Durga [1] INTRODUCTION Ganglioneuroma (GN) is a benign tumor of neural crest origin, most [...], Ganglioneuroma (GN) is the most differentiated and benign variant of neuroblastic tumors, most commonly located in the posterior mediastinum, followed by the retroperitoneum and adrenal gland. Children of Keywords: Adrenal gland, ganglioneuroma, metastatic

Author(s): Sunil Pasricha [1]; Garima Durga (corresponding author) [1]; Anila Sharma [1]; Ankush Jajodia [2]; Shivendra Singh [3]; Gurudutt Gupta [1]; Meenakshi Kamboj [1]; Venkata Pradeep Babu Koyyala [4]; Manoj [...], Folliclular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm originating from folliclular dendritic cells, both nodally and extranodally. Its primary presentation as a large colonic mass is rare and can be misdiagnosed as epithelial tumor/soft tissue tumor both clinically and through histomorphology. Due to its rarity and limited consensus guidelines about its management, it presents as a diagnostic and therapeutic challenge for pathologists and oncologists. However, accurate diagnosis is imperative due to its distinct prognostic and therapeutic implications. Herein we report, two cases of extranodal FDCS of colon with the aim of contributing to the management of this uncommon entity. Keywords: CD21, CD23, folliclular dendritic cell sarcoma, gastrointestinal tract

Author(s): Saloni Pahwa (corresponding author) [1]; Anila Sharma [1]; Meenakshi Kamboj [1]; Gurudutt Gupta [1]; Sunil Pasricha [1] INTRODUCTION Gestational trophoblastic neoplasms (GTNs) are a rare group of gestational trophoblastic [...], Gestational choriocarcinomas are malignant neoplasms generally arising in the uterus in women of childbearing age. These are aggressive tumors with a high incidence of metastasis to vascular organs such as the lung, liver, and brain. Renal metastasis is extremely rare with low incidence rate and very few cases have been reported in literature. Hereby, we report a rare case of metastatic choriocarcinoma to the kidney in a 29-year-old female 10 years after resection of a hydatidiform mole. The histopathological diagnosis was made on a nephrectomy specimen. Pelvic and abdominal scan did not show any abnormal radiological findings. She was started on first-line chemotherapy and showed a complete response. In conclusion, gestational or primary nongestational choriocarcinomas should always be considered as a differential diagnosis in young females of reproductive age group presenting with flank abdominal pain, unexplained hematuria, and atypical renal tumor histology. Keywords: Chemotherapy, gestational choriocarcinoma, hydatidiform mole, metastasis

Author(s): Sunil Pasricha [1]; Ankush Jajodia [2]; Anila Sharma [1]; Divya Bansal (corresponding author) [1]; Ullas Batra [3]; Gurudutt Gupta [1]; Garima Durga [1]; Meenakshi Kamboj [1]; Shrinidhi Nathany [4]; [...], Nuclear protein in testis (NUT) midline carcinoma is a poorly differentiated tumor, is more common in midline anatomic sites, and involves young adults and children mainly. Primary pulmonary NUT midline carcinoma (NMC) is a rare and poorly defined entity in the prevailing literature. Being a highly aggressive and fatal neoplasm, it gets incumbent for the oncologists and the pathologists to be aware of this entity as it holds distinct management protocol and prognosis. Currently, BET inhibitors (BETi) and histone deactylase inhibitors have shown promising results as targeted therapies in clinical trials in head and neck NMC. We present a case report of NMC of primary pulmonary location in a young male with widespread bony metastasis. Keywords: Mediastinum, metastasis, nuclear protein in testis midline carcinoma, pulmonary, radiotherapy