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In the domain of environmental science, pollutants of nanoscale plastic dimensions are acknowledged as subjects of intricate significance. Such entities, though minuscule, present formidable challenges to ecological systems and human health. The diminutive dimensions of these contaminants render their detection arduous, thus demanding the inception of avant-garde methodologies. The present manuscript postulates the employment of the tetraphenylethylene functional group with a fused xanthene (TPEF), a distinguished fluorophore, as an exemplary system for the discernment of nanoplastic particulates. The synthesis and characterization of TPEF have been exhaustively elucidated, revealing its paramount fluorescence attributes and inherent affinity for interaction with nanoplastics. When subjected to comparison with TPEF, nanoplastics are observed to manifest a more pronounced fluorescent luminescence than when associated with the conventional Nile Red (NR). Particularly, the TPEF has shown exceptional affinity for polystyrene (PS) nanoplastics. Further, the resilience of nanoplastics within the hypocotyl epidermis of soybeans, as well as their persistence in mung bean sprouts subsequent to rigorous rinsing protocols, has been meticulously examined. Additionally, this investigation furnishes empirical data signifying the existence of nano-dimensional plastic contaminants within HeLa cellular structures. The urgency of addressing the environmental ramifications engendered by these diminutive yet potent plastic constituents is emphatically highlighted in this manuscript. TPEF paves the way for prospective explorations, with the aspiration of devising efficacious mitigation strategies. Such strategies might encompass delineating the trajectories undertaken by nanoplastics within trophic networks or their ingress into human cellular architectures.

Alzheimer’s disease (AD), an amyloid-related disease, seriously endangers the health of elderly individuals. According to current research, its main pathogenic factor is the amyloid protein, which is a kind of fibrillar aggregate formed by noncovalent self-assembly of proteins. Based on the characteristics of aggregation-induced emission (AIE), a bislactosyl-decorated tetraphenylethylene (TPE) molecule TMNL (TPE + malononitrile + lactose), bearing two malononitrile substituents, was designed and synthesized in this work. The amphiphilic TMNL could self-assemble into fluorescent organic nanoparticles (FONs) with near-infrared (NIR) fluorescence emission in physiological PBS (phosphate buffered saline), achieving excellent fluorescent enhancement (47-fold) upon its combination with Aβ1–42 fibrils. TMNL was successfully applied to image Aβ1–42 plaques in the brain tissue of AD transgenic mice, and due to the AIE properties of TMNL, no additional rinsing process was necessary. It is believed that the probe reported in this work should be useful for the sensitive detection and accurate localization mapping of Aβ1–42 aggregates related to Alzheimer’s disease.

Two kinds of AIE-active fluorescent organic nanoparticles were designed and constructed as anti-counterfeiting photoresponsive materials. One is fluorescent organic nanoparticles (TPELs) based on a self-assembly strategy, which were self-assembled from novel amphiphilic tetraphenylethylene (TPE) molecules decorated with a lactose moiety and different photoresponsive tags. The other is polymeric fluorescent organic nanoparticles (F-TPEs) derived from the nanoprecipitation strategy, which utilized pluronic copolymer F127 to encapsulate hydrophobic TPEs without lactosyl modifications. Upon UV light irradiation, these AIE-active materials exhibit different photooxidation behaviors in an aqueous solution to give cyan, orange and green fluorescence emissions, and they were successfully used as an anti-counterfeiting fluorescent hydrogel and ink. [ABSTRACT FROM AUTHOR]