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1. Autonomic Dysfunction Among Adult Survivors of Childhood Cancer in the St. Jude Lifetime Cohort Study

Author

Groarke, John D., Ness, Kirsten K., Dhaduk, Rikeenkumar, Plana, Juan C., Durand, Jean Bernard, Luepker, Russell V., Joshi, Vijaya M., Ehrhardt, Matthew, Mulrooney, Daniel A., Dixon, Stephanie B., Nohria, Anju, Green, Daniel M., Howell, Rebecca M., Srivastava, Deo Kumar, Jefferies, John L., Robison, Leslie L., Hudson, Melissa M., and Armstrong, Gregory T.

Published
2024
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2. Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer

Author

Wang, Yuehan, Ronckers, Cécile M., van Leeuwen, Flora E., Moskowitz, Chaya S., Leisenring, Wendy, Armstrong, Gregory T., de Vathaire, Florent, Hudson, Melissa M., Kuehni, Claudia E., Arnold, Michael A., Demoor-Goldschmidt, Charlotte, Green, Daniel M., Henderson, Tara O., Howell, Rebecca M., Ehrhardt, Matthew J., Neglia, Joseph P., Oeffinger, Kevin C., van der Pal, Helena J. H., Robison, Leslie L., Schaapveld, Michael, Turcotte, Lucie M., Waespe, Nicolas, Kremer, Leontien C. M., and Teepen, Jop C.

Published
2023
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3. Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Otth, Maria, Kasteler, Rahel, Mulder, Renée L., Agrusa, Jennifer, Armenian, Saro H., Barnea, Dana, Bergeron, Anne, Bhatt, Neel S., Bourke, Stephen J., Constine, Louis S., Goutaki, Myrofora, Green, Daniel M., Hennewig, Ulrike, Houdouin, Veronique, Hudson, Melissa M., Kremer, Leontien, Latzin, Philipp, Ng, Antony, Oeffinger, Kevin C., Schindera, Christina, Skinner, Roderick, Sommer, Grit, Srinivasan, Saumini, Stokes, Dennis C., Versluys, Birgitta, Waespe, Nicolas, Weiner, Daniel J., Dietz, Andrew C., and Kuehni, Claudia E.

Published
2024
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4. A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Author

van Kalsbeek, Rebecca J., Hudson, Melissa M., Mulder, Renée L., Ehrhardt, Matthew, Green, Daniel M., Mulrooney, Daniel A., Hakkert, Jessica, den Hartogh, Jaap, Nijenhuis, Anouk, van Santen, Hanneke M., Schouten-van Meeteren, Antoinette Y. N., van Tinteren, Harm, Verbruggen, Lisanne C., Conklin, Heather M., Jacola, Lisa M., Webster, Rachel Tillery, Partanen, Marita, Kollen, Wouter J. W., Grootenhuis, Martha A., Pieters, Rob, and Kremer, Leontien C. M.

Published
2023
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6. Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Author

van Kalsbeek, Rebecca J., Hudson, Melissa M., Mulder, Renée L., Ehrhardt, Matthew, Green, Daniel M., Mulrooney, Daniel A., Hakkert, Jessica, den Hartogh, Jaap, Nijenhuis, Anouk, van Santen, Hanneke M., Schouten-van Meeteren, Antoinette Y. N., van Tinteren, Harm, Verbruggen, Lisanne C., Conklin, Heather M., Jacola, Lisa M., Webster, Rachel Tillery, Partanen, Marita, Kollen, Wouter J. W., Grootenhuis, Martha A., Pieters, Rob, and Kremer, Leontien C. M.

Published
2024
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7. The accuracy of estimating equations for the evaluation of kidney function in adult survivors of unilateral, nonmetastatic, non‐syndromic Wilms tumor: A pilot study from the St. Jude Lifetime Cohort Study.

Author

Green, Daniel M., Wang, Mingjuan, Krasin, Matthew J., Davidoff, Andrew M., Srivastava, DeoKumar, Jay, Dennis W., Ness, Kirsten K., Shulkin, Barry L., Lanctot, Jennifer Q., Shelton, Kyla C., Brennan, Rachel C., Mulrooney, Daniel A., Ehrhardt, Matthew J., Dixon, Stephanie B., Kurt, Beth A., Robison, Leslie L., Hudson, Melissa M., and Spunt, Sheri L.

Published
2025
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10. Prediabetes and Associated Risk of Cardiovascular Events and Chronic Kidney Disease Among Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort

Author

Dixon, Stephanie B., primary, Wang, Fang, additional, Lu, Lu, additional, Wilson, Carmen L., additional, Green, Daniel M., additional, Merchant, Thomas E., additional, Srivastava, Deo Kumar, additional, Delaney, Angela, additional, Howell, Rebecca M., additional, Jefferies, John L., additional, Robison, Leslie L., additional, Ness, Kirsten K., additional, Hudson, Melissa M., additional, Chemaitilly, Wassim, additional, and Armstrong, Gregory T., additional

Published
2024
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11. Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Otth, Maria, primary, Kasteler, Rahel, additional, Mulder, Renée L, additional, Agrusa, Jennifer, additional, Armenian, Saro H, additional, Barnea, Dana, additional, Bergeron, Anne, additional, Bhatt, Neel S, additional, Bourke, Stephen J, additional, Constine, Louis S, additional, Goutaki, Myrofora, additional, Green, Daniel M, additional, Hennewig, Ulrike, additional, Houdouin, Veronique, additional, Hudson, Melissa M, additional, Kremer, Leontien, additional, Latzin, Philipp, additional, Ng, Antony, additional, Oeffinger, Kevin C, additional, Schindera, Christina, additional, Skinner, Roderick, additional, Sommer, Grit, additional, Srinivasan, Saumini, additional, Stokes, Dennis C, additional, Versluys, Birgitta, additional, Waespe, Nicolas, additional, Weiner, Daniel J, additional, Dietz, Andrew C, additional, and Kuehni, Claudia E, additional

Published
2023
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12. Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer

Author

Zorg en O&O, Cancer, Child Health, MS Radiotherapie, Wang, Yuehan, Ronckers, Cécile M., van Leeuwen, Flora E., Moskowitz, Chaya S., Leisenring, Wendy, Armstrong, Gregory T., de Vathaire, Florent, Hudson, Melissa M., Kuehni, Claudia E., Arnold, Michael A., Demoor-Goldschmidt, Charlotte, Green, Daniel M., Henderson, Tara O., Howell, Rebecca M., Ehrhardt, Matthew J., Neglia, Joseph P., Oeffinger, Kevin C., van der Pal, Helena J.H., Robison, Leslie L., Schaapveld, Michael, Turcotte, Lucie M., Waespe, Nicolas, Kremer, Leontien C.M., Teepen, Jop C., Haddy, Nadia, Diallo, Ibrahima, Baker, K. Scott, de González, Amy Berrington, Conces, Miriam R., Constine, Louis S., Hawkins, Mike, Loonen, Jacqueline J., Louwerens, Marloes, Janssens, Geert O., Mellemkjaer, Lene, Reulen, Raoul, Winther, Jeanette F., Zorg en O&O, Cancer, Child Health, MS Radiotherapie, Wang, Yuehan, Ronckers, Cécile M., van Leeuwen, Flora E., Moskowitz, Chaya S., Leisenring, Wendy, Armstrong, Gregory T., de Vathaire, Florent, Hudson, Melissa M., Kuehni, Claudia E., Arnold, Michael A., Demoor-Goldschmidt, Charlotte, Green, Daniel M., Henderson, Tara O., Howell, Rebecca M., Ehrhardt, Matthew J., Neglia, Joseph P., Oeffinger, Kevin C., van der Pal, Helena J.H., Robison, Leslie L., Schaapveld, Michael, Turcotte, Lucie M., Waespe, Nicolas, Kremer, Leontien C.M., Teepen, Jop C., Haddy, Nadia, Diallo, Ibrahima, Baker, K. Scott, de González, Amy Berrington, Conces, Miriam R., Constine, Louis S., Hawkins, Mike, Loonen, Jacqueline J., Louwerens, Marloes, Janssens, Geert O., Mellemkjaer, Lene, Reulen, Raoul, and Winther, Jeanette F.

Published
2023

13. Assisted reproductive technology use and outcomes in childhood cancer survivors.

Author

Keefe, Kimberly W., Lanes, Andrea, Stratton, Kayla, Green, Daniel M., Chow, Eric J., Oeffinger, Kevin C., Barton, Sara, Diller, Lisa, Yasui, Yutaka, Leisenring, Wendy M., Armstrong, Gregory T., and Ginsburg, Elizabeth S.

Subjects
REPRODUCTIVE technology, CHILDHOOD cancer, CANCER survivors, INDUCED ovulation, OVARIAN reserve, MENSTRUAL cycle
Abstract

Background: Treatment exposures for childhood cancer reduce ovarian reserve. However, the success of assisted reproductive technology (ART) among female survivors is not well established. Methods: Five‐year survivors of childhood cancer in the Childhood Cancer Survivor Study were linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System, which captures national ART outcomes. The authors assessed the live birth rate, the relative risk (RR) with 95% confidence intervals (95% CIs), and associations with treatment exposure using generalized estimating equations to account for multiple ovarian stimulations per individual. Siblings from a random sample of survivors were recruited to serve as a comparison group. Results: Among 9885 female survivors, 137 (1.4%; median age at diagnosis, 10 years [range, 0–20 years]; median years of follow‐up after age 18 years, 11 years [range, 2–11 years]) underwent 224 ovarian stimulations using autologous or donor eggs and/or gestational carriers (157 autologous ovarian stimulation cycles, 67 donor ovarian stimulation cycles). In siblings, 33 (1.4%) underwent 51 autologous or donor ovarian stimulations. Of those who used embryos from autologous eggs without using gestational carriers, 97 survivors underwent 155 stimulations, resulting in 49 live births, for a 31.6% chance of live birth per ovarian stimulation (vs. 38.3% for siblings; p =.39) and a 43.9% chance of live birth per transfer (vs. 50.0%; p =.33). Prior treatment with cranial radiation therapy (RR, 0.44; 95% CI, 0.20–0.97) and pelvic radiation therapy (RR, 0.33; 95% CI, 0.15–0.73) resulted in a reduced chance of live birth compared with siblings. The likelihood of live birth after ART treatment in survivors was not affected by alkylator exposure (cyclophosphamide‐equivalent dose, ≥8000 mg/m2 vs. none; RR, 1.04; 95% CI, 0.52–2.05). Conclusions: Childhood cancer survivors are as likely to undergo treatment using ART as sibling controls. The success of ART treatment was not reduced after alkylator exposure. The results from the current study provide needed guidance on the use of ART in this population. Linking the Childhood Cancer Survivor Study database to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System revealed that childhood cancer survivors are as likely to undergo treatment with assisted reproductive technology as their siblings. The success of assisted reproductive technology was not reduced after alkylator exposure. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Supplementary Table S2 from Predicting Relapse in Favorable Histology Wilms Tumor Using Gene Expression Analysis: A Report from the Renal Tumor Committee of the Children's Oncology Group

Author

Huang, Chiang-Ching, primary, Gadd, Samantha, primary, Breslow, Norman, primary, Cutcliffe, Colleen, primary, Sredni, Simone T., primary, Helenowski, Irene B., primary, Dome, Jeffrey S., primary, Grundy, Paul E., primary, Green, Daniel M., primary, Fritsch, Michael K., primary, and Perlman, Elizabeth J., primary

Published
2023
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16. Data from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Author

Hudson, Melissa M., primary, Ehrhardt, Matthew J., primary, Bhakta, Nickhill, primary, Baassiri, Malek, primary, Eissa, Hesham, primary, Chemaitilly, Wassim, primary, Green, Daniel M., primary, Mulrooney, Daniel A., primary, Armstrong, Gregory T., primary, Brinkman, Tara M., primary, Klosky, James L., primary, Krull, Kevin R., primary, Sabin, Noah D., primary, Wilson, Carmen L., primary, Huang, I-Chan, primary, Bass, Johnnie K., primary, Hale, Karen, primary, Kaste, Sue, primary, Khan, Raja B., primary, Srivastava, Deo Kumar, primary, Yasui, Yutaka, primary, Joshi, Vijaya M., primary, Srinivasan, Saumini, primary, Stokes, Dennis, primary, Hoehn, Mary Ellen, primary, Wilson, Matthew, primary, Ness, Kirsten K., primary, and Robison, Leslie L., primary

Published
2023
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17. Supplemental Table 2 from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Author

Hudson, Melissa M., primary, Ehrhardt, Matthew J., primary, Bhakta, Nickhill, primary, Baassiri, Malek, primary, Eissa, Hesham, primary, Chemaitilly, Wassim, primary, Green, Daniel M., primary, Mulrooney, Daniel A., primary, Armstrong, Gregory T., primary, Brinkman, Tara M., primary, Klosky, James L., primary, Krull, Kevin R., primary, Sabin, Noah D., primary, Wilson, Carmen L., primary, Huang, I-Chan, primary, Bass, Johnnie K., primary, Hale, Karen, primary, Kaste, Sue, primary, Khan, Raja B., primary, Srivastava, Deo Kumar, primary, Yasui, Yutaka, primary, Joshi, Vijaya M., primary, Srinivasan, Saumini, primary, Stokes, Dennis, primary, Hoehn, Mary Ellen, primary, Wilson, Matthew, primary, Ness, Kirsten K., primary, and Robison, Leslie L., primary

Published
2023
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18. Supplementary Data from A Novel Locus Predicts Spermatogenic Recovery among Childhood Cancer Survivors Exposed to Alkylating Agents

Author

Sapkota, Yadav, primary, Wilson, Carmen L., primary, Zaidi, Asifa K., primary, Moon, Wonjong, primary, Fon Tacer, Klementina, primary, Lu, Lu, primary, Liu, Qi, primary, Baedke, Jessica, primary, Dhaduk, Rikeenkumar, primary, Wang, Zhaoming, primary, Chemaitilly, Wassim, primary, Krasin, Matthew J., primary, Berry, Fred B., primary, Zhang, Jinghui, primary, Hudson, Melissa M., primary, Robison, Leslie L., primary, Green, Daniel M., primary, and Yasui, Yutaka, primary

Published
2023
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19. Supplementary Table 1 from Cigarette Smoking and Pulmonary Function in Adult Survivors of Childhood Cancer Exposed to Pulmonary-Toxic Therapy: Results from the St. Jude Lifetime Cohort Study

Author

Oancea, S. Cristina, primary, Gurney, James G., primary, Ness, Kirsten K., primary, Ojha, Rohit P., primary, Tyc, Vida L., primary, Klosky, James L., primary, Srivastava, DeoKumar, primary, Stokes, Dennis C., primary, Robison, Leslie L., primary, Hudson, Melissa M., primary, and Green, Daniel M., primary

Published
2023
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20. Supplementary Figure 1 from Cigarette Smoking and Pulmonary Function in Adult Survivors of Childhood Cancer Exposed to Pulmonary-Toxic Therapy: Results from the St. Jude Lifetime Cohort Study

Author

Oancea, S. Cristina, primary, Gurney, James G., primary, Ness, Kirsten K., primary, Ojha, Rohit P., primary, Tyc, Vida L., primary, Klosky, James L., primary, Srivastava, DeoKumar, primary, Stokes, Dennis C., primary, Robison, Leslie L., primary, Hudson, Melissa M., primary, and Green, Daniel M., primary

Published
2023
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21. Supplementary Methods from A Novel Locus Predicts Spermatogenic Recovery among Childhood Cancer Survivors Exposed to Alkylating Agents

Author

Sapkota, Yadav, primary, Wilson, Carmen L., primary, Zaidi, Asifa K., primary, Moon, Wonjong, primary, Fon Tacer, Klementina, primary, Lu, Lu, primary, Liu, Qi, primary, Baedke, Jessica, primary, Dhaduk, Rikeenkumar, primary, Wang, Zhaoming, primary, Chemaitilly, Wassim, primary, Krasin, Matthew J., primary, Berry, Fred B., primary, Zhang, Jinghui, primary, Hudson, Melissa M., primary, Robison, Leslie L., primary, Green, Daniel M., primary, and Yasui, Yutaka, primary

Published
2023
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22. Data from A Novel Locus Predicts Spermatogenic Recovery among Childhood Cancer Survivors Exposed to Alkylating Agents

Author

Sapkota, Yadav, primary, Wilson, Carmen L., primary, Zaidi, Asifa K., primary, Moon, Wonjong, primary, Fon Tacer, Klementina, primary, Lu, Lu, primary, Liu, Qi, primary, Baedke, Jessica, primary, Dhaduk, Rikeenkumar, primary, Wang, Zhaoming, primary, Chemaitilly, Wassim, primary, Krasin, Matthew J., primary, Berry, Fred B., primary, Zhang, Jinghui, primary, Hudson, Melissa M., primary, Robison, Leslie L., primary, Green, Daniel M., primary, and Yasui, Yutaka, primary

Published
2023
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23. Supplementary Table 2 from Cigarette Smoking and Pulmonary Function in Adult Survivors of Childhood Cancer Exposed to Pulmonary-Toxic Therapy: Results from the St. Jude Lifetime Cohort Study

Author

Oancea, S. Cristina, primary, Gurney, James G., primary, Ness, Kirsten K., primary, Ojha, Rohit P., primary, Tyc, Vida L., primary, Klosky, James L., primary, Srivastava, DeoKumar, primary, Stokes, Dennis C., primary, Robison, Leslie L., primary, Hudson, Melissa M., primary, and Green, Daniel M., primary

Published
2023
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24. Supplemental Table 1 from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Author

Hudson, Melissa M., primary, Ehrhardt, Matthew J., primary, Bhakta, Nickhill, primary, Baassiri, Malek, primary, Eissa, Hesham, primary, Chemaitilly, Wassim, primary, Green, Daniel M., primary, Mulrooney, Daniel A., primary, Armstrong, Gregory T., primary, Brinkman, Tara M., primary, Klosky, James L., primary, Krull, Kevin R., primary, Sabin, Noah D., primary, Wilson, Carmen L., primary, Huang, I-Chan, primary, Bass, Johnnie K., primary, Hale, Karen, primary, Kaste, Sue, primary, Khan, Raja B., primary, Srivastava, Deo Kumar, primary, Yasui, Yutaka, primary, Joshi, Vijaya M., primary, Srinivasan, Saumini, primary, Stokes, Dennis, primary, Hoehn, Mary Ellen, primary, Wilson, Matthew, primary, Ness, Kirsten K., primary, and Robison, Leslie L., primary

Published
2023
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27. Supplementary Figure Legends from Cigarette Smoking and Pulmonary Function in Adult Survivors of Childhood Cancer Exposed to Pulmonary-Toxic Therapy: Results from the St. Jude Lifetime Cohort Study

Author

Oancea, S. Cristina, primary, Gurney, James G., primary, Ness, Kirsten K., primary, Ojha, Rohit P., primary, Tyc, Vida L., primary, Klosky, James L., primary, Srivastava, DeoKumar, primary, Stokes, Dennis C., primary, Robison, Leslie L., primary, Hudson, Melissa M., primary, and Green, Daniel M., primary

Published
2023
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31. Clinical Assessment of Late Health Outcomes in Survivors of Wilms Tumor

Author

Foster, Kayla L., primary, Salehabadi, Sedigheh Mirzaei, additional, Green, Daniel M., additional, Xing, Mengqi, additional, Ness, Kirsten K., additional, Krull, Kevin R., additional, Brinkman, Tara M., additional, Ehrhardt, Matthew J., additional, Chemaitilly, Wassim, additional, Dixon, Stephanie B., additional, Bhakta, Nickhill, additional, Brennan, Rachel C., additional, Krasin, Matthew J., additional, Davidoff, Andrew M., additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Mulrooney, Daniel A., additional

Published
2022
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32. Symptom profiles and health care utilization in long-term survivors of Survivors of Childhood Childhood Cancer Survivor (CCSS) study.

Author

Webster, Rachel Tillery, primary, Liu, Wei, additional, McGrady, Meghan Eileen, additional, Alberts, Nicole M., additional, Brinkman, Tara M., additional, Ness, Kirsten K., additional, Fuemmeler, Bernard, additional, Kunin-Batson, Alicia, additional, Srivastava, Deokumar, additional, Huang, I-Chan, additional, Armstrong, Gregory T., additional, Howell, Rebecca M., additional, Green, Daniel M., additional, Yasui, Yutaka, additional, and Krull, Kevin R., additional

Published
2022
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33. Bone mineral density (BMD) deficits in adult survivors of childhood cancer: Attributable risks and long-term consequences.

Author

Goodenough, Chelsea Goodliffe, primary, Baedke, Jessica L, additional, Li, Nan, additional, Brinkman, Tara M., additional, Wilson, Carmen Louise, additional, Delaney, Angela M., additional, Inaba, Hiroto, additional, Clark, Karen L, additional, Armstrong, Gregory T., additional, Talleur, Aimee C., additional, Pui, Ching-Hon, additional, Green, Daniel M., additional, Merchant, Thomas E., additional, Srivastava, Deo Kumar, additional, Yasui, Yutaka, additional, Hudson, Melissa M., additional, Robison, Leslie L., additional, Kaste, Sue C., additional, Ness, Kirsten K., additional, and Chemaitilly, Wassim, additional

Published
2022
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35. Attributable Risk and Consequences of Bone Mineral Density Deficits in Childhood Cancer Survivors.

Author

Goodenough, Chelsea G., Baedke, Jessica L., Delaney, Angela M., Wilson, Carmen L., Brinkman, Tara M., Im, Cindy, Ware, Megan E., Inaba, Hiroto, Clark, Karen L., Armstrong, Gregory T., Mulrooney, Daniel A., Pui, Ching-Hon, Green, Daniel M., Merchant, Thomas E., Srivastava, Deo Kumar, Yasui, Yutaka, Hudson, Melissa M., Robison, Leslie L., Kaste, Sue C., and Ness, Kirsten K.

Published
2025
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37. Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Author

van Kalsbeek, Rebecca J., Hudson, Melissa M., Mulder, Renée L., Ehrhardt, Matthew, Green, Daniel M., Mulrooney, Daniel A., Hakkert, Jessica, den Hartogh, Jaap, Nijenhuis, Anouk, van Santen, Hanneke M., Schouten-van Meeteren, Antoinette Y. N., van Tinteren, Harm, Verbruggen, Lisanne C., Conklin, Heather M., Jacola, Lisa M., Webster, Rachel Tillery, Partanen, Marita, Kollen, Wouter J. W., Grootenhuis, Martha A., Pieters, Rob, and Kremer, Leontien C. M.

Published
2023
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38. Primary hypothyroidism in childhood cancer survivors: Prevalence, risk factors, and long-term consequences.

Author

Chemaitilly W, Li Z, Brinkman TM, Delaney A, Huang S, Bjornard KL, Lam CG, Wilson CL, Barnes N, Clark KL, Krasin MJ, Metzger ML, Sheyn A, Bishop MW, Sabin ND, Howell RM, Helmig S, Shulkin BL, Triplett BM, Pui CH, Gajjar A, Srivastava DK, Green DM, Armstrong GT, Robison LL, Hudson MM, Ness KK, Sklar CA, and Krull KR

Subjects
Adolescent, Adult, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Male, Prevalence, Quality of Life, Retrospective Studies, Risk Factors, Cancer Survivors psychology, Hypothyroidism epidemiology, Leukemia, Myeloid, Acute complications
Abstract

Background: Data on primary hypothyroidism and its long-term impact on the health, cognition, and quality of life (QOL) of childhood cancer survivors are limited. This study examined the prevalence of and risk factors for primary hypothyroidism and its associations with physical, neurocognitive, and psychosocial outcomes., Methods: This was a retrospective study with a cross-sectional health outcome analysis of an established cohort comprising 2965 survivors of childhood cancer (52.8% male; median current age, 30.9 years, median time since cancer diagnosis, 22.3 years). Multivariable logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between primary hypothyroidism and cancer-related risk factors, cardiovascular disease risk factors, frailty, neurocognitive and QOL outcomes, social attainment, and subsequent thyroid carcinoma. Associations between serum free thyroxine and thyrotropin levels at assessment and health outcomes were explored., Results: The prevalence of primary hypothyroidism was 14.7% (95% CI, 13.5%-16.0%). It was more likely in females (OR, 1.06; 95% CI, 1.03-1.08), was less likely in non-Whites (OR, 0.96; 95% CI, 0.93-0.99), was associated with thyroid radiotherapy (higher risk at higher doses), and was more common if cancer was diagnosed at an age ≥ 15.0 years versus an age < 5 years (OR, 1.05; 95% CI, 1.01-1.09). Primary hypothyroidism was associated with frailty (OR, 1.54; 95% CI, 1.05-2.26), dyslipidemia (OR, 1.52; 95% CI, 1.14-2.04), impaired physical QOL (OR, 1.66; 95% CI, 1.12-2.48), and having health care insurance (OR, 1.51; 95% CI, 1.07-2.12)., Conclusions: Primary hypothyroidism is common in survivors and is associated with unfavorable physical health and QOL outcomes. The impact of thyroid hormone replacement practices on these outcomes should be investigated further., (© 2021 American Cancer Society.)

Published
2022
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