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3. Intelligence, educational attainment, and brain structure in those at familial high‐risk for schizophrenia or bipolar disorder

Author

Zwarte, Sonja MC, Brouwer, Rachel M, Agartz, Ingrid, Alda, Martin, Alonso‐Lana, Silvia, Bearden, Carrie E, Bertolino, Alessandro, Bonvino, Aurora, Bramon, Elvira, Buimer, Elizabeth EL, Cahn, Wiepke, Canales‐Rodríguez, Erick J, Cannon, Dara M, Cannon, Tyrone D, Caseras, Xavier, Castro‐Fornieles, Josefina, Chen, Qiang, Chung, Yoonho, De la Serna, Elena, Bonnin, Caterina Mar, Demro, Caroline, Di Giorgio, Annabella, Doucet, Gaelle E, Eker, Mehmet Cagdas, Erk, Susanne, Fatjó‐Vilas, Mar, Fears, Scott C, Foley, Sonya F, Frangou, Sophia, Fullerton, Janice M, Glahn, David C, Goghari, Vina M, Goikolea, Jose M, Goldman, Aaron L, Gonul, Ali Saffet, Gruber, Oliver, Hajek, Tomas, Hawkins, Emma L, Heinz, Andreas, Ongun, Ceren Hidiroglu, Hillegers, Manon HJ, Houenou, Josselin, Pol, Hilleke E Hulshoff, Hultman, Christina M, Ingvar, Martin, Johansson, Viktoria, Jönsson, Erik G, Kane, Fergus, Kempton, Matthew J, Koenis, Marinka MG, Kopecek, Miloslav, Krämer, Bernd, Lawrie, Stephen M, Lenroot, Rhoshel K, Marcelis, Machteld, Mattay, Venkata S, McDonald, Colm, Meyer‐Lindenberg, Andreas, Michielse, Stijn, Mitchell, Philip B, Moreno, Dolores, Murray, Robin M, Mwangi, Benson, Nabulsi, Leila, Newport, Jason, Olman, Cheryl A, Os, Jim, Overs, Bronwyn J, Ozerdem, Aysegul, Pergola, Giulio, Picchioni, Marco M, Piguet, Camille, Pomarol‐Clotet, Edith, Radua, Joaquim, Ramsay, Ian S, Richter, Anja, Roberts, Gloria, Salvador, Raymond, Aydogan, Aybala Saricicek, Sarró, Salvador, Schofield, Peter R, Simsek, Esma M, Simsek, Fatma, Soares, Jair C, Sponheim, Scott R, Sugranyes, Gisela, Toulopoulou, Timothea, Tronchin, Giulia, Vieta, Eduard, Walter, Henrik, Weinberger, Daniel R, Whalley, Heather C, Wu, Mon‐Ju, Yalin, Nefize, Andreassen, Ole A, Ching, Christopher RK, Thomopoulos, Sophia I, Erp, Theo GM, Jahanshad, Neda, and Thompson, Paul M

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Brain Disorders, Bipolar Disorder, Clinical Research, Serious Mental Illness, Neurosciences, Schizophrenia, Mental Health, Aetiology, 2.3 Psychological, social and economic factors, 2.1 Biological and endogenous factors, Mental health, Cognitive Dysfunction, Educational Status, Family, Genetic Predisposition to Disease, Humans, Intelligence, Magnetic Resonance Imaging, Neuroimaging, bipolar disorder, education, intelligence, neuroimaging, relatives, schizophrenia, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10-5 ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.

Published
2022

7. Principles and procedures for revising the hierarchical taxonomy of psychopathology.

Author

Forbes, Miriam K., primary, Ringwald, Whitney R., additional, Allen, Timothy, additional, Cicero, David C., additional, Clark, Lee Anna, additional, DeYoung, Colin G., additional, Eaton, Nicholas, additional, Kotov, Roman, additional, Krueger, Robert F., additional, Latzman, Robert D., additional, Martin, Elizabeth A., additional, Naragon-Gainey, Kristin, additional, Ruggero, Camilo J., additional, Waldman, Irwin D., additional, Brandes, Cassandra, additional, Fried, Eiko I., additional, Goghari, Vina M., additional, Hankin, Benjamin, additional, Sperry, Sarah, additional, Stanton, Kasey, additional, Aftab, Awais, additional, Lynam, Donald, additional, Roche, Michael, additional, and Wright, Aidan G. C., additional

Published
2024
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12. Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-Based Functional Magnetic Resonance Imaging Meta-analysis

Author

Fiorito, Anna M., primary, Aleman, André, additional, Blasi, Giuseppe, additional, Bourque, Josiane, additional, Cao, Hengyi, additional, Chan, Raymond C.K., additional, Chowdury, Asadur, additional, Conrod, Patricia, additional, Diwadkar, Vaibhav A., additional, Goghari, Vina M., additional, Guinjoan, Salvador, additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Kwon, Jun Soo, additional, Lieslehto, Johannes, additional, Lukow, Paulina B., additional, Meyer-Lindenberg, Andreas, additional, Modinos, Gemma, additional, Quarto, Tiziana, additional, Spilka, Michael J., additional, Shivakumar, Venkataram, additional, Venkatasubramanian, Ganesan, additional, Villarreal, Mirta, additional, Wang, Yi, additional, Wolf, Daniel H., additional, Yun, Je-Yeon, additional, Fakra, Eric, additional, and Sescousse, Guillaume, additional

Published
2023
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16. Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-based fMRI Meta-analysis

Author

Fiorito, Anna M., primary, Aleman, Andre, additional, Blasi, Giusepp, additional, Bourque, Josiane, additional, Cao, Hengyi, additional, Chan, Raymond C.K., additional, Chowdury, Asadur, additional, Conrod, Patricia, additional, Diwadkar, Vaibhav A., additional, Goghari, Vina M., additional, Guinjoan, Salvador, additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Kwon, Jun Soo, additional, Lieslehto, Johannes, additional, Lukow, Paulina B., additional, Meyer-Lindenberg, Andreas, additional, Modinos, Gemma, additional, Quarto, Tiziana, additional, Spilka, Michael J., additional, Shivakumar, Venkataram, additional, Venkatasubramanian, Ganesan, additional, Villarreal, Mirta, additional, Wang, Yi, additional, Wolf, Daniel H., additional, Yun, Je-Yeon, additional, Fakra, Eric, additional, and Sescousse, Guillaume, additional

Published
2022
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19. Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.

Author

de Zwarte, Sonja MC, de Zwarte, Sonja MC, Brouwer, Rachel M, Agartz, Ingrid, Alda, Martin, Alonso-Lana, Silvia, Bearden, Carrie E, Bertolino, Alessandro, Bonvino, Aurora, Bramon, Elvira, Buimer, Elizabeth EL, Cahn, Wiepke, Canales-Rodríguez, Erick J, Cannon, Dara M, Cannon, Tyrone D, Caseras, Xavier, Castro-Fornieles, Josefina, Chen, Qiang, Chung, Yoonho, De la Serna, Elena, Del Mar Bonnin, Caterina, Demro, Caroline, Di Giorgio, Annabella, Doucet, Gaelle E, Eker, Mehmet Cagdas, Erk, Susanne, Fatjó-Vilas, Mar, Fears, Scott C, Foley, Sonya F, Frangou, Sophia, Fullerton, Janice M, Glahn, David C, Goghari, Vina M, Goikolea, Jose M, Goldman, Aaron L, Gonul, Ali Saffet, Gruber, Oliver, Hajek, Tomas, Hawkins, Emma L, Heinz, Andreas, Hidiroglu Ongun, Ceren, Hillegers, Manon HJ, Houenou, Josselin, Hulshoff Pol, Hilleke E, Hultman, Christina M, Ingvar, Martin, Johansson, Viktoria, Jönsson, Erik G, Kane, Fergus, Kempton, Matthew J, Koenis, Marinka MG, Kopecek, Miloslav, Krämer, Bernd, Lawrie, Stephen M, Lenroot, Rhoshel K, Marcelis, Machteld, Mattay, Venkata S, McDonald, Colm, Meyer-Lindenberg, Andreas, Michielse, Stijn, Mitchell, Philip B, Moreno, Dolores, Murray, Robin M, Mwangi, Benson, Nabulsi, Leila, Newport, Jason, Olman, Cheryl A, van Os, Jim, Overs, Bronwyn J, Ozerdem, Aysegul, Pergola, Giulio, Picchioni, Marco M, Piguet, Camille, Pomarol-Clotet, Edith, Radua, Joaquim, Ramsay, Ian S, Richter, Anja, Roberts, Gloria, Salvador, Raymond, Saricicek Aydogan, Aybala, Sarró, Salvador, Schofield, Peter R, Simsek, Esma M, Simsek, Fatma, Soares, Jair C, Sponheim, Scott R, Sugranyes, Gisela, Toulopoulou, Timothea, Tronchin, Giulia, Vieta, Eduard, Walter, Henrik, Weinberger, Daniel R, Whalley, Heather C, Wu, Mon-Ju, Yalin, Nefize, Andreassen, Ole A, Ching, Christopher RK, Thomopoulos, Sophia I, van Erp, Theo GM, Jahanshad, Neda, Thompson, Paul M, de Zwarte, Sonja MC, de Zwarte, Sonja MC, Brouwer, Rachel M, Agartz, Ingrid, Alda, Martin, Alonso-Lana, Silvia, Bearden, Carrie E, Bertolino, Alessandro, Bonvino, Aurora, Bramon, Elvira, Buimer, Elizabeth EL, Cahn, Wiepke, Canales-Rodríguez, Erick J, Cannon, Dara M, Cannon, Tyrone D, Caseras, Xavier, Castro-Fornieles, Josefina, Chen, Qiang, Chung, Yoonho, De la Serna, Elena, Del Mar Bonnin, Caterina, Demro, Caroline, Di Giorgio, Annabella, Doucet, Gaelle E, Eker, Mehmet Cagdas, Erk, Susanne, Fatjó-Vilas, Mar, Fears, Scott C, Foley, Sonya F, Frangou, Sophia, Fullerton, Janice M, Glahn, David C, Goghari, Vina M, Goikolea, Jose M, Goldman, Aaron L, Gonul, Ali Saffet, Gruber, Oliver, Hajek, Tomas, Hawkins, Emma L, Heinz, Andreas, Hidiroglu Ongun, Ceren, Hillegers, Manon HJ, Houenou, Josselin, Hulshoff Pol, Hilleke E, Hultman, Christina M, Ingvar, Martin, Johansson, Viktoria, Jönsson, Erik G, Kane, Fergus, Kempton, Matthew J, Koenis, Marinka MG, Kopecek, Miloslav, Krämer, Bernd, Lawrie, Stephen M, Lenroot, Rhoshel K, Marcelis, Machteld, Mattay, Venkata S, McDonald, Colm, Meyer-Lindenberg, Andreas, Michielse, Stijn, Mitchell, Philip B, Moreno, Dolores, Murray, Robin M, Mwangi, Benson, Nabulsi, Leila, Newport, Jason, Olman, Cheryl A, van Os, Jim, Overs, Bronwyn J, Ozerdem, Aysegul, Pergola, Giulio, Picchioni, Marco M, Piguet, Camille, Pomarol-Clotet, Edith, Radua, Joaquim, Ramsay, Ian S, Richter, Anja, Roberts, Gloria, Salvador, Raymond, Saricicek Aydogan, Aybala, Sarró, Salvador, Schofield, Peter R, Simsek, Esma M, Simsek, Fatma, Soares, Jair C, Sponheim, Scott R, Sugranyes, Gisela, Toulopoulou, Timothea, Tronchin, Giulia, Vieta, Eduard, Walter, Henrik, Weinberger, Daniel R, Whalley, Heather C, Wu, Mon-Ju, Yalin, Nefize, Andreassen, Ole A, Ching, Christopher RK, Thomopoulos, Sophia I, van Erp, Theo GM, Jahanshad, Neda, and Thompson, Paul M

Abstract

First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10-5 ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.

Published
2022

20. Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

Author

de Zwarte, Sonja M. C., Brouwer, Rachel M., Agartz, Ingrid, Alda, Martin, Alonso-Lana, Silvia, Bearden, Carrie E., Bertolino, Alessandro, Bonvino, Aurora, Bramon, Elvira, Buimer, Elizabeth E. L., Cahn, Wiepke, Canales-Rodríguez, Erick J., Cannon, Dara M., Cannon, Tyrone D., Caseras, Xavier, Castro-Fornieles, Josefina, Chen, Qiang, Chung, Yoonho, De la Serna, Elena, Del Mar Bonnin, Caterina, Demro, Caroline, Di Giorgio, Annabella, Doucet, Gaelle E., Eker, Mehmet Cagdas, Erk, Susanne, Fatjó-Vilas, Mar, Fears, Scott C., Foley, Sonya F., Frangou, Sophia, Fullerton, Janice M., Glahn, David C., Goghari, Vina M., Goikolea, Jose M., Goldman, Aaron L., Gonul, Ali Saffet, Gruber, Oliver, Hajek, Tomas, Hawkins, Emma L., Heinz, Andreas, Hidiroglu Ongun, Ceren, Hillegers, Manon H.J., Houenou, Josselin, Hulshoff Pol, Hilleke E., Hultman, Christina M., Ingvar, Martin, Johansson, Viktoria, Jönsson, Erik G., Kane, Fergus, Kempton, Matthew J., Koenis, Marinka M. G., Kopecek, Miloslav, Krämer, Bernd, Lawrie, Stephen M., Lenroot, Rhoshel K., Marcelis, Machteld, Mattay, Venkata S., McDonald, Colm, Meyer-Lindenberg, Andreas, Michielse, Stijn, Mitchell, Philip B., Moreno, Dolores, Murray, Robin M., Mwangi, Benson, Nabulsi, Leila, Newport, Jason, Olman, Cheryl A., van Os, Jim, Overs, Bronwyn J., Ozerdem, Aysegul, Pergola, Giulio, Picchioni, Marco M., Piguet, Camille, Pomarol-Clotet, Edith, Radua, Joaquim, Ramsay, Ian S., Richter, Anja, Roberts, Gloria, Salvador, Raymond, Saricicek Aydogan, Aybala, Sarró, Salvador, Schofield, Peter R., Simsek, Esma M., Simsek, Fatma, Soares, Jair C., Sponheim, Scott R., Sugranyes, Gisela, Toulopoulou, Timothea, Tronchin, Giulia, Vieta, Eduard, Walter, Henrik, Weinberger, Daniel R., Whalley, Heather C., Wu, Mon-Ju, Yalin, Nefize, Andreassen, Ole A., Ching, Christopher R. K., Thomopoulos, Sophia I., van Erp, Theo G. M., Jahanshad, Neda, Thompson, Paul M., Kahn, René S., van Haren, Neeltje E. M., de Zwarte, Sonja M. C., Brouwer, Rachel M., Agartz, Ingrid, Alda, Martin, Alonso-Lana, Silvia, Bearden, Carrie E., Bertolino, Alessandro, Bonvino, Aurora, Bramon, Elvira, Buimer, Elizabeth E. L., Cahn, Wiepke, Canales-Rodríguez, Erick J., Cannon, Dara M., Cannon, Tyrone D., Caseras, Xavier, Castro-Fornieles, Josefina, Chen, Qiang, Chung, Yoonho, De la Serna, Elena, Del Mar Bonnin, Caterina, Demro, Caroline, Di Giorgio, Annabella, Doucet, Gaelle E., Eker, Mehmet Cagdas, Erk, Susanne, Fatjó-Vilas, Mar, Fears, Scott C., Foley, Sonya F., Frangou, Sophia, Fullerton, Janice M., Glahn, David C., Goghari, Vina M., Goikolea, Jose M., Goldman, Aaron L., Gonul, Ali Saffet, Gruber, Oliver, Hajek, Tomas, Hawkins, Emma L., Heinz, Andreas, Hidiroglu Ongun, Ceren, Hillegers, Manon H.J., Houenou, Josselin, Hulshoff Pol, Hilleke E., Hultman, Christina M., Ingvar, Martin, Johansson, Viktoria, Jönsson, Erik G., Kane, Fergus, Kempton, Matthew J., Koenis, Marinka M. G., Kopecek, Miloslav, Krämer, Bernd, Lawrie, Stephen M., Lenroot, Rhoshel K., Marcelis, Machteld, Mattay, Venkata S., McDonald, Colm, Meyer-Lindenberg, Andreas, Michielse, Stijn, Mitchell, Philip B., Moreno, Dolores, Murray, Robin M., Mwangi, Benson, Nabulsi, Leila, Newport, Jason, Olman, Cheryl A., van Os, Jim, Overs, Bronwyn J., Ozerdem, Aysegul, Pergola, Giulio, Picchioni, Marco M., Piguet, Camille, Pomarol-Clotet, Edith, Radua, Joaquim, Ramsay, Ian S., Richter, Anja, Roberts, Gloria, Salvador, Raymond, Saricicek Aydogan, Aybala, Sarró, Salvador, Schofield, Peter R., Simsek, Esma M., Simsek, Fatma, Soares, Jair C., Sponheim, Scott R., Sugranyes, Gisela, Toulopoulou, Timothea, Tronchin, Giulia, Vieta, Eduard, Walter, Henrik, Weinberger, Daniel R., Whalley, Heather C., Wu, Mon-Ju, Yalin, Nefize, Andreassen, Ole A., Ching, Christopher R. K., Thomopoulos, Sophia I., van Erp, Theo G. M., Jahanshad, Neda, Thompson, Paul M., Kahn, René S., and van Haren, Neeltje E. M.

Abstract

First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10-5 ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.

Published
2022
Full Text
View/download PDF

21. Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

Author

de Zwarte, Sonja M.C., Brouwer, Rachel M., Agartz, Ingrid, Alda, Martin, Alonso-Lana, Silvia, Bearden, Carrie E., Bertolino, Alessandro, Bonvino, Aurora, Bramon, Elvira, Buimer, Elizabeth E.L., Cahn, Wiepke, Canales-Rodríguez, Erick J., Cannon, Dara M., Cannon, Tyrone D., Caseras, Xavier, Castro-Fornieles, Josefina, Chen, Qiang, Chung, Yoonho, De la Serna, Elena, del Mar Bonnin, Caterina, Demro, Caroline, Di Giorgio, Annabella, Doucet, Gaelle E., Eker, Mehmet Cagdas, Erk, Susanne, Fatjó-Vilas, Mar, Fears, Scott C., Foley, Sonya F., Frangou, Sophia, Fullerton, Janice M., Glahn, David C., Goghari, Vina M., Goikolea, Jose M., Goldman, Aaron L., Gonul, Ali Saffet, Gruber, Oliver, Hajek, Tomas, Hawkins, Emma L., Heinz, Andreas, Hidiroglu Ongun, Ceren, Hillegers, Manon H.J., Houenou, Josselin, Hulshoff Pol, Hilleke E., Hultman, Christina M., Ingvar, Martin, Johansson, Viktoria, Jönsson, Erik G., Kane, Fergus, Kempton, Matthew J., Koenis, Marinka M.G., Kopecek, Miloslav, Krämer, Bernd, Lawrie, Stephen M., Lenroot, Rhoshel K., Marcelis, Machteld, Mattay, Venkata S., McDonald, Colm, Meyer-Lindenberg, Andreas, Michielse, Stijn, Mitchell, Philip B., Moreno, Dolores, Murray, Robin M., Mwangi, Benson, Nabulsi, Leila, Newport, Jason, Olman, Cheryl A., van Os, Jim, Overs, Bronwyn J., Ozerdem, Aysegul, Pergola, Giulio, Picchioni, Marco M., Piguet, Camille, Pomarol-Clotet, Edith, Radua, Joaquim, Ramsay, Ian S., Richter, Anja, Roberts, Gloria, Salvador, Raymond, Saricicek Aydogan, Aybala, Sarró, Salvador, Schofield, Peter R., Simsek, Esma M., Simsek, Fatma, Soares, Jair C., Sponheim, Scott R., Sugranyes, Gisela, Toulopoulou, Timothea, Tronchin, Giulia, Vieta, Eduard, Walter, Henrik, Weinberger, Daniel R., Whalley, Heather C., Wu, Mon Ju, Yalin, Nefize, Andreassen, Ole A., Ching, Christopher R.K., Thomopoulos, Sophia I., van Erp, Theo G.M., Jahanshad, Neda, Thompson, Paul M., Kahn, René S., van Haren, Neeltje E.M., de Zwarte, Sonja M.C., Brouwer, Rachel M., Agartz, Ingrid, Alda, Martin, Alonso-Lana, Silvia, Bearden, Carrie E., Bertolino, Alessandro, Bonvino, Aurora, Bramon, Elvira, Buimer, Elizabeth E.L., Cahn, Wiepke, Canales-Rodríguez, Erick J., Cannon, Dara M., Cannon, Tyrone D., Caseras, Xavier, Castro-Fornieles, Josefina, Chen, Qiang, Chung, Yoonho, De la Serna, Elena, del Mar Bonnin, Caterina, Demro, Caroline, Di Giorgio, Annabella, Doucet, Gaelle E., Eker, Mehmet Cagdas, Erk, Susanne, Fatjó-Vilas, Mar, Fears, Scott C., Foley, Sonya F., Frangou, Sophia, Fullerton, Janice M., Glahn, David C., Goghari, Vina M., Goikolea, Jose M., Goldman, Aaron L., Gonul, Ali Saffet, Gruber, Oliver, Hajek, Tomas, Hawkins, Emma L., Heinz, Andreas, Hidiroglu Ongun, Ceren, Hillegers, Manon H.J., Houenou, Josselin, Hulshoff Pol, Hilleke E., Hultman, Christina M., Ingvar, Martin, Johansson, Viktoria, Jönsson, Erik G., Kane, Fergus, Kempton, Matthew J., Koenis, Marinka M.G., Kopecek, Miloslav, Krämer, Bernd, Lawrie, Stephen M., Lenroot, Rhoshel K., Marcelis, Machteld, Mattay, Venkata S., McDonald, Colm, Meyer-Lindenberg, Andreas, Michielse, Stijn, Mitchell, Philip B., Moreno, Dolores, Murray, Robin M., Mwangi, Benson, Nabulsi, Leila, Newport, Jason, Olman, Cheryl A., van Os, Jim, Overs, Bronwyn J., Ozerdem, Aysegul, Pergola, Giulio, Picchioni, Marco M., Piguet, Camille, Pomarol-Clotet, Edith, Radua, Joaquim, Ramsay, Ian S., Richter, Anja, Roberts, Gloria, Salvador, Raymond, Saricicek Aydogan, Aybala, Sarró, Salvador, Schofield, Peter R., Simsek, Esma M., Simsek, Fatma, Soares, Jair C., Sponheim, Scott R., Sugranyes, Gisela, Toulopoulou, Timothea, Tronchin, Giulia, Vieta, Eduard, Walter, Henrik, Weinberger, Daniel R., Whalley, Heather C., Wu, Mon Ju, Yalin, Nefize, Andreassen, Ole A., Ching, Christopher R.K., Thomopoulos, Sophia I., van Erp, Theo G.M., Jahanshad, Neda, Thompson, Paul M., Kahn, René S., and van Haren, Neeltje E.M.

Abstract

First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = −0.42, p = 3 × 10−5), with weak evidence of IQ reductions among BD-FDRs (d = −0.23, p =.045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.

Published
2022

24. Modeling Relations Between Event-Related Potential Factors and Broader Versus Narrower Dimensions of Externalizing Psychopathology.

Author

Pasion, Rita, Ribes-Guardiola, Pablo, Patrick, Christopher, Stewart, Rochelle A., Paiva, Tiago O., Macedo, Inês, Barbosa, Fernando, Brislin, Sarah J., Martin, Elizabeth A., Blain, Scott D., Cooper, Samuel E., Ruocco, Anthony C., Tiego, Jeggan, Wilson, Sylia, and Goghari, Vina M.

Subjects
*EVOKED potentials (Electrophysiology), *EXTERNALIZING behavior, *ALCOHOLISM, *ADOLESCENT psychopathology
Abstract

The organization of the Hierarchical Taxonomy of Psychopathology (HiTOP) model provides unique opportunities to evaluate whether neural risk measures operate as indicators of broader latent liabilities (e.g., externalizing proneness) or narrower expressions (e.g., antisociality and alcohol abuse). Following this approach, the current study recruited a sample of 182 participants (54% female) who completed measures of externalizing psychopathology (also internalizing) and associated traits. Participants also completed three tasks (Flanker-No Threat, Flanker-Threat, and Go/No-Go tasks) with event-related potential (ERP) measurement. Three variants of two research domain criteria (RDoC)-based neurophysiological indicators—P3 and error-related negativity (ERN)—were extracted from these tasks and used to model two latent ERP factors. Scores on these two ERP factors independently predicted externalizing factor scores when accounting for their covariance with sex—suggesting distinct neural processes contributing to the broad externalizing factor. No predictive relation with the broad internalizing factor was found for either ERP factor. Analyses at the finer-grained level revealed no unique predictive relations of either ERP factor with any specific externalizing symptom variable when accounting for the broad externalizing factor, indicating that ERN and P3 index general liability for problems in this spectrum. Overall, this study provides new insights about neural processes in externalizing psychopathology at broader and narrower levels of the HiTOP hierarchy. General Scientific Summary: The Hierarchical Taxonomy Model of Psychopathology argues that some etiological factors might operate at broader levels of the psychopathological spectrum, conferring general risk for clinical problems. Our results show that error-related negativity (ERN) and P3 responses are indicators of distinct neural processes and that both account for externalizing proneness. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.

Author

de Zwarte SMC, Brouwer RM, Agartz I, Alda M, Alonso-Lana S, Bearden CE, Bertolino A, Bonvino A, Bramon E, Buimer EEL, Cahn W, Canales-Rodríguez EJ, Cannon DM, Cannon TD, Caseras X, Castro-Fornieles J, Chen Q, Chung Y, De la Serna E, Del Mar Bonnin C, Demro C, Di Giorgio A, Doucet GE, Eker MC, Erk S, Fatjó-Vilas M, Fears SC, Foley SF, Frangou S, Fullerton JM, Glahn DC, Goghari VM, Goikolea JM, Goldman AL, Gonul AS, Gruber O, Hajek T, Hawkins EL, Heinz A, Hidiroglu Ongun C, Hillegers MHJ, Houenou J, Hulshoff Pol HE, Hultman CM, Ingvar M, Johansson V, Jönsson EG, Kane F, Kempton MJ, Koenis MMG, Kopecek M, Krämer B, Lawrie SM, Lenroot RK, Marcelis M, Mattay VS, McDonald C, Meyer-Lindenberg A, Michielse S, Mitchell PB, Moreno D, Murray RM, Mwangi B, Nabulsi L, Newport J, Olman CA, van Os J, Overs BJ, Ozerdem A, Pergola G, Picchioni MM, Piguet C, Pomarol-Clotet E, Radua J, Ramsay IS, Richter A, Roberts G, Salvador R, Saricicek Aydogan A, Sarró S, Schofield PR, Simsek EM, Simsek F, Soares JC, Sponheim SR, Sugranyes G, Toulopoulou T, Tronchin G, Vieta E, Walter H, Weinberger DR, Whalley HC, Wu MJ, Yalin N, Andreassen OA, Ching CRK, Thomopoulos SI, van Erp TGM, Jahanshad N, Thompson PM, Kahn RS, and van Haren NEM

Subjects
Bipolar Disorder complications, Bipolar Disorder diagnostic imaging, Cognitive Dysfunction diagnostic imaging, Family, Humans, Magnetic Resonance Imaging, Schizophrenia complications, Schizophrenia diagnostic imaging, Schizophrenia etiology, Bipolar Disorder pathology, Cognitive Dysfunction pathology, Educational Status, Genetic Predisposition to Disease, Intelligence physiology, Neuroimaging, Schizophrenia pathology
Abstract

First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10 -5 ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment., (© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)

Published
2022
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