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1. Longitudinal biomarkers and kidney disease progression after acute kidney injury.

Author

Wen, Yumeng, Xu, Leyuan, Melchinger, Isabel, Thiessen-Philbrook, Heather, Moledina, Dennis G, Coca, Steven G, Hsu, Chi-Yuan, Go, Alan S, Liu, Kathleen D, Siew, Edward D, Ikizler, T Alp, Chinchilli, Vernon M, Kaufman, James S, Kimmel, Paul L, Himmelfarb, Jonathan, Cantley, Lloyd G, Parikh, Chirag R, and ASSESS-AKI Consortium

Subjects
ASSESS-AKI Consortium, Kidney, Animals, Mice, Disease Progression, Inflammation, Prospective Studies, Renal Insufficiency, Chronic, Acute Kidney Injury, Biomarkers, Chronic kidney disease, Diagnostics, Epidemiology, Nephrology, Prevention, Kidney Disease, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Renal and urogenital, Good Health and Well Being
Abstract

BACKGROUNDLongitudinal investigations of murine acute kidney injury (AKI) suggest that injury and inflammation may persist long after the initial insult. However, the evolution of these processes and their prognostic values are unknown in patients with AKI.METHODSIn a prospective cohort of 656 participants hospitalized with AKI, we measured 7 urine and 2 plasma biomarkers of kidney injury, inflammation, and tubular health at multiple time points from the diagnosis to 12 months after AKI. We used linear mixed-effect models to estimate biomarker changes over time, and we used Cox proportional hazard regressions to determine their associations with a composite outcome of chronic kidney disease (CKD) incidence and progression. We compared the gene expression kinetics of biomarkers in murine models of repair and atrophy after ischemic reperfusion injury (IRI).RESULTSAfter 4.3 years, 106 and 52 participants developed incident CKD and CKD progression, respectively. Each SD increase in the change of urine KIM-1, MCP-1, and plasma TNFR1 from baseline to 12 months was associated with 2- to 3-fold increased risk for CKD, while the increase in urine uromodulin was associated with 40% reduced risk for CKD. The trajectories of these biological processes were associated with progression to kidney atrophy in mice after IRI.CONCLUSIONSustained tissue injury and inflammation, and slower restoration of tubular health, are associated with higher risk of kidney disease progression. Further investigation into these ongoing biological processes may help researchers understand and prevent the AKI-to-CKD transition.FUNDINGNIH and NIDDK (grants U01DK082223, U01DK082185, U01DK082192, U01DK082183, R01DK098233, R01DK101507, R01DK114014, K23DK100468, R03DK111881, K01DK120783, and R01DK093771).

Published
2023

2. Breast arterial calcification is associated with incident atrial fibrillation among older but not younger post-menopausal women

Author

Iribarren, Carlos, Chandra, Malini, Parikh, Rishi V, Sanchez, Gabriela, Sam, Danny L, Azamian, Farima Faith, Cho, Hyo-Min, Ding, Huanjun, Molloi, Sabee, and Go, Alan S

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Aging, Cancer, Prevention, Cardiovascular, Breast Cancer, Heart Disease, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Atrial fibrillation/flutter, Breast arterial calcification, Cohort study, Women’s health
Abstract

AimsThe goal of this study was to examine the association of breast arterial calcification (BAC) presence and quantity with incident atrial fibrillation (AF) in a large cohort of post-menopausal women.Methods and resultsWe conducted a longitudinal cohort study among women free of clinically overt cardiovascular disease and AF at baseline (between October 2012 and February 2015) when they attended mammography screening. Atrial fibrillation incidence was ascertained using diagnostic codes and natural language processing. Among 4908 women, 354 incident cases of AF (7%) were ascertained after a mean (standard deviation) of 7 (2) years of follow-up. In Cox regression adjusting for a propensity score for BAC, BAC presence vs. absence was not significantly associated with AF [hazard ratio (HR) = 1.12; 95% confidence interval (CI), 0.89-1.42; P = 0.34]. However, a significant (a priori hypothesized) age by BAC interaction was found (P = 0.02) such that BAC presence was not associated with incident AF in women aged 60-69 years (HR = 0.83; 95% CI, 0.63-1.15; P = 0.26) but was significantly associated with incident AF in women aged 70-79 years (HR = 1.75; 95% CI, 1.21-2.53; P = 0.003). No evidence of dose-response relationship between BAC gradation and AF was noted in the entire cohort or in age groups separately.ConclusionOur results demonstrate, for the first time, an independent association between BAC and AF in women over age 70 years.

Published
2023

3. Clinical decision support to Optimize Care of patients with Atrial Fibrillation or flutter in the Emergency department: protocol of a stepped-wedge cluster randomized pragmatic trial (O’CAFÉ trial)

Author

Vinson, David R, Rauchwerger, Adina S, Karadi, Chandu A, Shan, Judy, Warton, E Margaret, Zhang, Jennifer Y, Ballard, Dustin W, Mark, Dustin G, Hofmann, Erik R, Cotton, Dale M, Durant, Edward J, Lin, James S, Sax, Dana R, Poth, Luke S, Gamboa, Stephen H, Ghiya, Meena S, Kene, Mamata V, Ganapathy, Anuradha, Whiteley, Patrick M, Bouvet, Sean C, Babakhanian, Leon, Kwok, Edward W, Solomon, Matthew D, Go, Alan S, and Reed, Mary E

Subjects
Health Services and Systems, Health Sciences, Clinical Research, Clinical Trials and Supportive Activities, Comparative Effectiveness Research, Heart Disease, Health Services, Emergency Care, Prevention, Cardiovascular, 7.3 Management and decision making, Management of diseases and conditions, Stroke, Good Health and Well Being, Adult, Humans, Anticoagulants, Atrial Fibrillation, Atrial Flutter, Decision Support Systems, Clinical, Emergency Service, Hospital, Randomized Controlled Trials as Topic, Pragmatic Clinical Trials as Topic, Atrial fibrillation, Atrial flutter, Emergency medicine, Randomized trial, Cardioversion, Patient admission, Kaiser Permanente CREST Network, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, General & Internal Medicine, Clinical sciences, Epidemiology, Health services and systems
Abstract

BackgroundManagement of adults with atrial fibrillation (AF) or atrial flutter in the emergency department (ED) includes rate reduction, cardioversion, and stroke prevention. Different approaches to these components of care may lead to variation in frequency of hospitalization and stroke prevention actions, with significant implications for patient experience, cost of care, and risk of complications. Standardization using evidence-based recommendations could reduce variation in management, preventable hospitalizations, and stroke risk.MethodsWe describe the rationale for our ED-based AF treatment recommendations. We also describe the development of an electronic clinical decision support system (CDSS) to deliver these recommendations to emergency physicians at the point of care. We implemented the CDSS at three pilot sites to assess feasibility and solicit user feedback. We will evaluate the impact of the CDSS on hospitalization and stroke prevention actions using a stepped-wedge cluster randomized pragmatic clinical trial across 13 community EDs in Northern California.DiscussionWe hypothesize that the CDSS intervention will reduce hospitalization of adults with isolated AF or atrial flutter presenting to the ED and increase anticoagulation prescription in eligible patients at the time of ED discharge and within 30 days. If our hypotheses are confirmed, the treatment protocol and CDSS could be recommended to other EDs to improve management of adults with AF or atrial flutter.Trial registrationClinicalTrials.gov NCT05009225 .  Registered on 17 August 2021.

Published
2023

5. Considerations in Controlling for Urine Concentration for Biomarkers of Kidney Disease Progression After Acute Kidney Injury

Author

Wen, Yumeng, Thiessen-Philbrook, Heather, Moledina, Dennis G, Kaufman, James S, Reeves, W Brian, Ghahramani, Nasrollah, Ikizler, T Alp, Go, Alan S, Liu, Kathleen D, Siew, Eddie D, Himmelfarb, Jonathan, Kimmel, Paul L, Hsu, Chi-yuan, and Parikh, Chirag R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Renal and urogenital, Good Health and Well Being, acute kidney injury, biomarker, chronic kidney disease, urine concentration, urine creatinine, urine osmolarity, Biomedical and clinical sciences, Health sciences
Abstract

IntroductionBiomarkers of acute kidney injury (AKI) are often indexed to urine creatinine (UCr) or urine osmolarity (UOsm) to control for urine concentration. We evaluated how these approaches affect the biomarker-outcome association in patients with AKI.MethodsThe Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury Study was a cohort of hospitalized patients with and without AKI between 2009 and 2015. Using Cox proportional hazards regression, we assessed the associations and predictions (C-statistics) of urine biomarkers with a composite outcome of incident chronic kidney disease (CKD) and CKD progression. We used 4 approaches to account for urine concentration: indexing and adjusting for UCr and UOsm.ResultsAmong 1538 participants, 769 (50%) had AKI and 300 (19.5%) developed composite CKD outcome at median follow-up of 4.7 years. UCr and UOsm during hospitalization were inversely associated with the composite CKD outcome. The associations and predictions with CKD were significantly strengthened after indexing or adjusting for UCr or UOsm for urine kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1) in patients with AKI. There was no significant improvement with indexing or adjusting UCr or UOsm for albumin, neutrophil gelatinase-associated lipocalin (NGAL), and chitinase 3-like 1 (YKL-40). Uromodulin's (UMOD) inverse association with the outcome was significantly blunted after indexing but not adjusting for UCr or UOsm.ConclusionUCr and UOsm during hospitalization are inversely associated with development and progression of CKD. Indexing or adjusting for UCr or UOsm strengthened associations and improved predictions for CKD for only some biomarkers. Incorporating urinary concentration should be individualized for each biomarker in research and clinical applications.

Published
2022

7. Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Appel, Lawrence J., Cohen, Debbie, Dember, Laura, Go, Alan S., Lash, James P., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Baudier, Robin L., Orlandi, Paula F., Yang, Wei, Chen, Hsiang-Yu, Bansal, Nisha, Blackston, J. Walker, Chen, Jing, Deo, Rajat, Dobre, Mirela, He, Hua, He, Jiang, Ricardo, Ana C., Shafi, Tariq, Srivastava, Anand, Xie, Dawei, Susztak, Katalin, Feldman, Harold I., and Anderson, Amanda H.

Published
2024
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10. Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Dember, Laura M., Landis, J. Richard, Townsend, Raymond R., Appel, Lawrence, Fink, Jeffrey, Rahman, Mahboob, Horwitz, Edward J., Taliercio, Jonathan J., Rao, Panduranga, Sondheimer, James H., Lash, James P., Chen, Jing, Go, Alan S., Parsa, Afshin, Rankin, Tracy, Wulczyn, Kendra E., Shafi, Tariq, Anderson, Amanda, Rincon-Choles, Hernan, Clish, Clary B., Denburg, Michelle, Feldman, Harold I., He, Jiang, Hsu, Chi-yuan, Kelly, Tanika, Kimmel, Paul L., Mehta, Rupal, Nelson, Robert G., Ramachandran, Vasan, Ricardo, Ana, Shah, Vallabh O., Srivastava, Anand, Xie, Dawei, Rhee, Eugene P., and Kalim, Sahir

Published
2024
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11. Adherence to Plant-Based Diets and Risk of CKD Progression and All-Cause Mortality: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Lash, James P., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Amir, Saira, Kim, Hyunju, Hu, Emily A., Ricardo, Ana C., Mills, Katherine T., He, Jiang, Fischer, Michael J., Pradhan, Nishigandha, Tan, Thida C., Navaneethan, Sankar D., Dobre, Mirela, Anderson, Cheryl A.M., Appel, Lawrence J., and Rebholz, Casey M.

Published
2024
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12. Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study

Author

Appel, Lawrence J., Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Hernandez, Rosalba, Xie, Dawei, Wang, Xue, Jordan, Neil, Ricardo, Ana C., Anderson, Amanda H., Diamantidis, Clarissa J., Kusek, John W., Yaffe, Kristine, Lash, James P., and Fischer, Michael J.

Published
2024
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14. Proteomics of CKD progression in the chronic renal insufficiency cohort

Author

Dubin, Ruth F., Deo, Rajat, Ren, Yue, Wang, Jianqiao, Zheng, Zihe, Shou, Haochang, Go, Alan S., Parsa, Afshin, Lash, James P., Rahman, Mahboob, Hsu, Chi-yuan, Weir, Matthew R., Chen, Jing, Anderson, Amanda, Grams, Morgan E., Surapaneni, Aditya, Coresh, Josef, Li, Hongzhe, Kimmel, Paul L., Vasan, Ramachandran S., Feldman, Harold, Segal, Mark R., and Ganz, Peter

Published
2023
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16. Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study

Author

McCoy, Ian E, Hsu, Jesse Y, Bonventre, Joseph V, Parikh, Chirag R, Go, Alan S, Liu, Kathleen D, Ricardo, Ana C, Srivastava, Anand, Cohen, Debbie L, He, Jiang, Chen, Jing, Rao, Panduranga S, Muiru, Anthony N, and Hsu, Chi-yuan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Clinical Research, Renal and urogenital, Good Health and Well Being, Acute Kidney Injury, Adult, Biomarkers, Creatinine, Humans, Kidney Function Tests, Renal Insufficiency, Chronic, Acute kidney injury, Chronic kidney disease, Urology & Nephrology, Clinical sciences, Health services and systems, Nursing
Abstract

BackgroundMechanisms by which AKI leads to CKD progression remain unclear. Several urine biomarkers have been identified as independent predictors of progressive CKD. It is unknown whether AKI may result in long-term changes in these urine biomarkers, which may mediate the effect of AKI on CKD progression.MethodsWe selected 198 episodes of hospitalized AKI (defined as peak/nadir inpatient serum creatinine values ≥ 1.5) among adult participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. We matched the best non-AKI hospitalization (unique patients) for each AKI hospitalization using pre-hospitalization characteristics including eGFR and urine protein/creatinine ratio. Biomarkers were measured in banked urine samples collected at annual CRIC study visits.ResultsUrine biomarker measurements occurred a median of 7 months before and 5 months after hospitalization. There were no significant differences in the change in urine biomarker-to-creatinine ratio between the AKI and non-AKI groups: KIM-1/Cr + 9% vs + 7%, MCP-1/Cr + 4% vs + 1%, YKL-40/Cr + 7% vs -20%, EGF/Cr -11% vs -8%, UMOD/Cr -2% vs -7% and albumin/Cr + 17% vs + 13% (all p > 0.05).ConclusionIn this cohort of adults with CKD, AKI did not associate with long-term changes in urine biomarkers.

Published
2022

20. Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Hannan, Mary, Chen, Jinsong, Hsu, Jesse, Zhang, Xiaoming, Saunders, Milda R., Brown, Julia, McAdams-DeMarco, Mara, Mohanty, Madhumita Jena, Vyas, Rahul, Hajjiri, Zahraa, Carmona-Powell, Eunice, Meza, Natalie, Porter, Anna C., Ricardo, Ana C., and Lash, James P.

Published
2024
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21. Factors Associated With Non-vaccination for Influenza Among Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Dember, Laura M., Landis, J. Richard, Townsend, Raymond R., Fink, Jeffrey, Rahman, Mahboob, Horwitz, Edward J., Rao, Panduranga S., Sondheimer, James H., Go, Alan S., Hsu, Chi-yuan, Parsa, Afshin, Rankin, Tracy, Ishigami, Junichi, Jaar, Bernard G., Charleston, Jeanne B., Lash, James P., Brown, Julia, Chen, Jing, Mills, Katherine T., Taliercio, Jonathan J., Kansal, Sheru, Crews, Deidra C., Riekert, Kristin A., Dowdy, David W., Appel, Lawrence J., and Matsushita, Kunihiro

Published
2024
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24. Body mass index and chronic kidney disease outcomes after acute kidney injury: a prospective matched cohort study

Author

MacLaughlin, Helen L, Pike, Mindy, Selby, Nicholas M, Siew, Edward, Chinchilli, Vernon M, Guide, Andrew, Stewart, Thomas G, Himmelfarb, Jonathan, Go, Alan S, Parikh, Chirag R, Ghahramani, Nasrollah, Kaufman, James, Ikizler, T Alp, and Robinson-Cohen, Cassianne

Subjects
Epidemiology, Health Sciences, Kidney Disease, Prevention, Nutrition, Clinical Research, Obesity, Renal and urogenital, Good Health and Well Being, Acute Kidney Injury, Aged, Body Mass Index, Disease Progression, Female, Humans, Male, Middle Aged, Prospective Studies, Renal Insufficiency, Chronic, ASSESS-AKI Study Investigators, Body mass index, Kidney, Mortality, Clinical Sciences, Urology & Nephrology, Clinical sciences, Health services and systems, Nursing
Abstract

BackgroundAcute kidney injury (AKI) and obesity are independent risk factors for chronic kidney disease (CKD). This study aimed to determine if obesity modifies risk for CKD outcomes after AKI.MethodsThis prospective multisite cohort study followed adult survivors after hospitalization, with or without AKI. The primary outcome was a combined CKD event of incident CKD, progression of CKD and kidney failure, examined using time-to-event Cox proportional hazards models, adjusted for diabetes status, age, pre-existing CKD, cardiovascular disease status and intensive care unit admission, and stratified by study center. Body mass index (BMI) was added as an interaction term to examine effect modification by body size.ResultsThe cohort included 769 participants with AKI and 769 matched controls. After median follow-up of 4.3 years, among AKI survivors, the rate of the combined CKD outcome was 84.7 per1000-person-years with BMI ≥30 kg/m2, 56.4 per 1000-person-years with BMI 25-29.9 kg/m2, and 72.6 per 1000-person-years with BMI 20-24.9 kg/m2. AKI was associated with a higher risk of combined CKD outcomes; adjusted-HR 2.43 (95%CI 1.87-3.16), with no evidence that this was modified by BMI (p for interaction = 0.3). After adjustment for competing risk of death, AKI remained associated with a higher risk of the combined CKD outcome (subdistribution-HR 2.27, 95%CI 1.76-2.92) and similarly, there was no detectable effect of BMI modifying this risk.ConclusionsIn this post-hospitalization cohort, we found no evidence for obesity modifying the association between AKI and development or progression of CKD.

Published
2021

25. Race, Genetic Ancestry, and Estimating Kidney Function in CKD

Author

Hsu, Chi-Yuan, Yang, Wei, Parikh, Rishi V, Anderson, Amanda H, Chen, Teresa K, Cohen, Debbie L, He, Jiang, Mohanty, Madhumita J, Lash, James P, Mills, Katherine T, Muiru, Anthony N, Parsa, Afshin, Saunders, Milda R, Shafi, Tariq, Townsend, Raymond R, Waikar, Sushrut S, Wang, Jianqiao, Wolf, Myles, Tan, Thida C, Feldman, Harold I, and Go, Alan S

Subjects
Prevention, Kidney Disease, Genetics, Clinical Research, Renal and urogenital, Good Health and Well Being, Adult, Aged, Algorithms, Black People, Creatinine, Cross-Sectional Studies, Cystatin C, Ethnicity, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Racial Groups, Renal Insufficiency, Chronic, United States, CRIC Study Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundThe inclusion of race in equations to estimate the glomerular filtration rate (GFR) has become controversial. Alternative equations that can be used to achieve similar accuracy without the use of race are needed.MethodsIn a large national study involving adults with chronic kidney disease, we conducted cross-sectional analyses of baseline data from 1248 participants for whom data, including the following, had been collected: race as reported by the participant, genetic ancestry markers, and the serum creatinine, serum cystatin C, and 24-hour urinary creatinine levels.ResultsUsing current formulations of GFR estimating equations, we found that in participants who identified as Black, a model that omitted race resulted in more underestimation of the GFR (median difference between measured and estimated GFR, 3.99 ml per minute per 1.73 m2 of body-surface area; 95% confidence interval [CI], 2.17 to 5.62) and lower accuracy (percent of estimated GFR within 10% of measured GFR [P10], 31%; 95% CI, 24 to 39) than models that included race (median difference, 1.11 ml per minute per 1.73 m2; 95% CI, -0.29 to 2.54; P10, 42%; 95% CI, 34 to 50). The incorporation of genetic ancestry data instead of race resulted in similar estimates of the GFR (median difference, 1.33 ml per minute per 1.73 m2; 95% CI, -0.12 to 2.33; P10, 42%; 95% CI, 34 to 50). The inclusion of non-GFR determinants of the serum creatinine level (e.g., body-composition metrics and urinary excretion of creatinine) that differed according to race reported by the participants and genetic ancestry did not eliminate the misclassification introduced by removing race (or ancestry) from serum creatinine-based GFR estimating equations. In contrast, the incorporation of race or ancestry was not necessary to achieve similarly statistically unbiased (median difference, 0.33 ml per minute per 1.73 m2; 95% CI, -1.43 to 1.92) and accurate (P10, 41%; 95% CI, 34 to 49) estimates in Black participants when GFR was estimated with the use of cystatin C.ConclusionsThe use of the serum creatinine level to estimate the GFR without race (or genetic ancestry) introduced systematic misclassification that could not be eliminated even when numerous non-GFR determinants of the serum creatinine level were accounted for. The estimation of GFR with the use of cystatin C generated similar results while eliminating the negative consequences of the current race-based approaches. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others.).

Published
2021

26. Anticoagulant treatment satisfaction with warfarin and direct oral anticoagulants for venous thromboembolism

Author

Fang, Margaret C, Go, Alan S, Prasad, Priya A, Hsu, Jin-Wen, Fan, Dongjie, Portugal, Cecilia, Sung, Sue Hee, and Reynolds, Kristi

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Hematology, Cardiovascular, Administration, Oral, Aged, Anticoagulants, Female, Humans, Male, Personal Satisfaction, Retrospective Studies, Venous Thromboembolism, Warfarin, Venous thromboembolism, Treatment satisfaction, Direct oral anticoagulants, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Treatment options for patients with venous thromboembolism (VTE) include warfarin and direct oral anticoagulants (DOACs). Although DOACs are easier to administer than warfarin and do not require routine laboratory monitoring, few studies have directly assessed whether patients are more satisfied with DOACs. We surveyed adults from two large integrated health systems taking DOACs or warfarin for incident VTE occurring between January 1, 2015 and June 30, 2018. Treatment satisfaction was assessed using the validated Anti-Clot Treatment Scale (ACTS), divided into the ACTS Burdens and ACTS Benefits scores; higher scores indicate greater satisfaction. Mean treatment satisfaction was compared using multivariable linear regression, adjusting for patient demographic and clinical characteristics. The effect size of the difference in means was calculated using a Cohen's d (0.20 is considered a small effect and ≥ 0.80 is considered large). We surveyed 2217 patients, 969 taking DOACs and 1248 taking warfarin at the time of survey. Thirty-one point five percent of the cohort was aged ≥ 75 years and 43.1% were women. DOAC users were on average more satisfied with anticoagulant treatment, with higher adjusted mean ACTS Burdens (50.18 v. 48.01, p

Published
2021

28. Development and Validation of the American Heart Association’s PREVENT Equations

Author

Khan, Sadiya S., Matsushita, Kunihiro, Sang, Yingying, Ballew, Shoshana H., Grams, Morgan E., Surapaneni, Aditya, Blaha, Michael J., Carson, April P., Chang, Alexander R., Ciemins, Elizabeth, Go, Alan S., Gutierrez, Orlando M., Hwang, Shih-Jen, Jassal, Simerjot K., Kovesdy, Csaba P., Lloyd-Jones, Donald M., Shlipak, Michael G., Palaniappan, Latha P., Sperling, Laurence, Virani, Salim S., Tuttle, Katherine, Neeland, Ian J., Chow, Sheryl L., Rangaswami, Janani, Pencina, Michael J., Ndumele, Chiadi E., and Coresh, Josef

Published
2024
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30. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events

Author

Menez, Steven, Wen, Yumeng, Xu, Leyuan, Moledina, Dennis G., Thiessen-Philbrook, Heather, Hu, David, Obeid, Wassim, Bhatraju, Pavan K., Ikizler, T. Alp, Siew, Edward D., Chinchilli, Vernon M., Garg, Amit X., Go, Alan S., Liu, Kathleen D., Kaufman, James S., Kimmel, Paul L., Himmelfarb, Jonathan, Coca, Steven G., Cantley, Lloyd G., and Parikh, Chirag R.

Published
2023
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32. Fibroblast Growth Factor 23 and Risk of Heart Failure Subtype: The CRIC (Chronic Renal Insufficiency Cohort) Study

Author

Appel, Lawrence J., Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Lash, James P., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Leidner, Alexander S., Cai, Xuan, Zelnick, Leila R., Lee, Jungwha, Bansal, Nisha, Pasch, Andreas, Kansal, Mayank, Anderson, Amanda Hyre, Sondheimer, James H., Townsend, Raymond R., Shah, Sanjiv J., Wolf, Myles, Isakova, Tamara, and Mehta, Rupal C.

Published
2023
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33. Blood Pressure, Incident Cognitive Impairment, and Severity of CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Appel, Lawrence J., Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Lash, James P., Nelson, Robert G., Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Babroudi, Seda, Tighiouart, Hocine, Schrauben, Sarah J., Cohen, Jordana B., Fischer, Michael J., Rahman, Mahboob, Hsu, Chi-yuan, Sozio, Stephen M., Weir, Matthew, Sarnak, Mark, Yaffe, Kristine, Kurella Tamura, Manjula, and Drew, David

Published
2023
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35. Ultraprocessed Foods and Kidney Disease Progression, Mortality, and Cardiovascular Disease Risk in the CRIC Study

Author

Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Nelson, Robert G., Rahman, Mahboob, Shah, Vallabh O., Sullivan, Valerie K., Appel, Lawrence J., Anderson, Cheryl A.M., Kim, Hyunju, Unruh, Mark L., Lash, James P., Trego, Marsha, Sondheimer, James, Dobre, Mirela, Pradhan, Nishigandha, Rao, Panduranga S., Chen, Jing, He, Jiang, and Rebholz, Casey M.

Published
2023
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36. Cardiac Structure and Function and Subsequent Kidney Disease Progression in Adults With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Cohen, Debbie L., Feldman, Harold I., Lash, James P., Nelson, Robert G., Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Ishigami, Junichi, Kansal, Mayank, Mehta, Rupal, Srivastava, Anand, Rahman, Mahboob, Dobre, Mirela, Al-Kindi, Sadeer G., Go, Alan S., Navaneethan, Sankar D., Chen, Jing, He, Jiang, Bhat, Zeenat Yousuf, Jaar, Bernard G., Appel, Lawrence J., and Matsushita, Kunihiro

Published
2023
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46. Probing the Association between Acute Kidney Injury and Cardiovascular Outcomes

Author

McCoy, Ian E., Hsu, Jesse Y., Zhang, Xiaoming, Diamantidis, Clarissa J., Taliercio, Jonathan, Go, Alan S., Liu, Kathleen D., Drawz, Paul, Srivastava, Anand, Horwitz, Edward J., He, Jiang, Chen, Jing, Lash, James P., Weir, Matthew R., Hsu, Chi-yuan, Appel, Lawrence J., Cohen, Debbie L., Feldman, Harold I., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., and Unruh, Mark L.

Published
2023
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47. Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Baudier, Robin L., primary, Orlandi, Paula F., additional, Yang, Wei, additional, Chen, Hsiang-Yu, additional, Bansal, Nisha, additional, Blackston, J. Walker, additional, Chen, Jing, additional, Deo, Rajat, additional, Dobre, Mirela, additional, He, Hua, additional, He, Jiang, additional, Ricardo, Ana C., additional, Shafi, Tariq, additional, Srivastava, Anand, additional, Xie, Dawei, additional, Susztak, Katalin, additional, Feldman, Harold I., additional, Anderson, Amanda H., additional, Appel, Lawrence J., additional, Cohen, Debbie, additional, Dember, Laura, additional, Go, Alan S., additional, Lash, James P., additional, Nelson, Robert G., additional, Rahman, Mahboob, additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, and Unruh, Mark L., additional

Published
2024
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48. Applying natural language processing to identify emergency department and observation encounters for worsening heart failure

Author

Hamilton, Steven A., primary, Ambrosy, Andrew P., additional, Parikh, Rishi V., additional, Tan, Thida C., additional, Fitzpatrick, Jesse K., additional, Avula, Harshith R., additional, Sandhu, Alexander T., additional, Ku, Ivy A., additional, Go, Alan S., additional, Sax, Dana, additional, and Bhatt, Ankeet S., additional

Published
2024
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49. Five‐Year Cumulative Cardiovascular Health and Clinical Events in Patients With Chronic Kidney Disease: The CRIC Study

Author

Cao, Qiuyu, primary, Bi, Yufang, additional, Alvarado, Flor, additional, Anderson, Amanda H., additional, Mills, Katherine T., additional, Jaeger, Byron C., additional, Chen, Jing, additional, He, Jiang, additional, Bundy, Joshua D., additional, Appel, Lawrence J., additional, Cohen, Debbie, additional, Dember, Laura M., additional, Go, Alan S., additional, Lash, James P., additional, Nelson, Robert G., additional, Rahman, Mahboob, additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, and Unruh, Mark L., additional

Published
2024
Full Text
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50. Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study

Author

Hernandez, Rosalba, primary, Xie, Dawei, additional, Wang, Xue, additional, Jordan, Neil, additional, Ricardo, Ana C., additional, Anderson, Amanda H., additional, Diamantidis, Clarissa J., additional, Kusek, John W., additional, Yaffe, Kristine, additional, Lash, James P., additional, Fischer, Michael J., additional, Appel, Lawrence J., additional, Chen, Jing, additional, Cohen, Debbie L., additional, Feldman, Harold I., additional, Go, Alan S., additional, Nelson, Robert G., additional, Rahman, Mahboob, additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, and Unruh, Mark L., additional

Published
2024
Full Text
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