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Your search keyword '"Giudetti, Anna"' showing total 12 results
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12 results on '"Giudetti, Anna"'

1. M1-derived extracellular vesicles polarize recipient macrophages into M2-like macrophages and alter skeletal muscle homeostasis in a hyper-glucose environment

Author

Tacconi, Stefano, Vari, Francesco, Sbarigia, Carolina, Vardanyan, Diana, Longo, Serena, Mura, Francesco, Angilè, Federica, Jalabert, Audrey, Blangero, Ferninand, Eljaafari, Assia, Canaple, Laurence, Vergara, Daniele, Fanizzi, Francesco Paolo, Rossi, Marco, Da Silva, Claire Crola, Errazuriz-Cerda, Elizabeth, Cassin, Christel, Nieuwland, Rienk, Giudetti, Anna Maria, Rome, Sophie, and Dini, Luciana

Published
2024
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4. EPA and DHA Enhance CACT Promoter Activity by GABP/NRF2.

Author

Stanca, Eleonora, Spedicato, Francesco, Giudetti, Anna Maria, Giannotti, Laura, Di Chiara Stanca, Benedetta, Damiano, Fabrizio, and Siculella, Luisa

Subjects
OMEGA-3 fatty acids, LIVER cells, GENE expression, GENETIC transcription regulation, GENETIC regulation
Abstract

Carnitine-acylcarnitine translocase (CACT) is a nuclear-encoded mitochondrial carrier that catalyzes the transfer of long-chain fatty acids across the inner mitochondrial membrane for β-oxidation. In this study, we conducted a structural and functional characterization of the CACT promoter to investigate the molecular mechanism underlying the transcriptional regulation of the CACT gene by n-3 PUFA, EPA and DHA. In hepatic BRL3A cells, EPA and DHA stimulate CACT mRNA and protein expression. Deletion promoter analysis using a luciferase reporter gene assay identified a n-3 PUFA response region extending from −202 to −29 bp. This region did not contain a response element for PPARα, a well-known PUFA-responsive nuclear receptor. Instead, bioinformatic analysis revealed two highly conserved GABP responsive elements within this region. Overexpression of GABPα and GABPβ subunits, but not PPARα, increased CACT promoter activity, more remarkably upon treatment with EPA and DHA. ChIP assays showed that n3-PUFA enhanced the binding of GABPα to the −202/−29 bp sequence. Furthermore, both EPA and DHA induced nuclear accumulation of GABPα. In conclusion, our findings indicate that the upregulation of CACT by n3-PUFA in hepatic cells is independent from PPARα and could be mediated by GABP activation. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation

Author

Giuliani, Angelica, primary, Giudetti, Anna Maria, additional, Vergara, Daniele, additional, Del Coco, Laura, additional, Ramini, Deborah, additional, Caccese, Sara, additional, Sbriscia, Matilde, additional, Graciotti, Laura, additional, Fulgenzi, Gianluca, additional, Tiano, Luca, additional, Fanizzi, Francesco Paolo, additional, Olivieri, Fabiola, additional, Rippo, Maria Rita, additional, and Sabbatinelli, Jacopo, additional

Published
2023
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6. M1-derived extracellular vesicles polarize recipient macrophages into M2 and alter skeletal muscle homeostasis in a hyper-glucose environment

Author

Tacconi, Stefano, primary, Vari, Francesco, additional, Sbarigia, Carolina, additional, Vardanyan, Diana, additional, Longo, Serena, additional, Mura, Francesco, additional, Angile, Federica, additional, Jalabart, Audrey, additional, Vergara, Daniele, additional, Fanizzi, Francesco Paolo, additional, Rossi, Marco, additional, Errazuriz-Cerda, Elizabeth, additional, Cassin, Christel, additional, Nieuwland, Rienk, additional, Giudetti, Anna Maria, additional, Rome, Sophie, additional, and Dini, Luciana, additional

Published
2023
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8. Modulation of the Circulating Extracellular Vesicles in Response to Different Exercise Regimens and Study of Their Inflammatory Effects

Author

Maggio, Serena, primary, Canonico, Barbara, additional, Ceccaroli, Paola, additional, Polidori, Emanuela, additional, Cioccoloni, Andrea, additional, Giacomelli, Luca, additional, Ferri Marini, Carlo, additional, Annibalini, Giosuè, additional, Gervasi, Marco, additional, Benelli, Piero, additional, Fabbri, Francesco, additional, Del Coco, Laura, additional, Fanizzi, Francesco Paolo, additional, Giudetti, Anna Maria, additional, Lucertini, Francesco, additional, and Guescini, Michele, additional

Published
2023
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10. Androgen receptor in breast cancer: The “5W” questions

Author

Ravaioli, Sara, primary, Maltoni, Roberta, additional, Pasculli, Barbara, additional, Parrella, Paola, additional, Giudetti, Anna Maria, additional, Vergara, Daniele, additional, Tumedei, Maria Maddalena, additional, Pirini, Francesca, additional, and Bravaccini, Sara, additional

Published
2022
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12. Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study

Author

Liso, Marina, primary, Sila, Annamaria, additional, Verna, Giulio, additional, Scarano, Aurelia, additional, Donghia, Rossella, additional, Castellana, Fabio, additional, Cavalcanti, Elisabetta, additional, Pesole, Pasqua Letizia, additional, Sommella, Eduardo Maria, additional, Lippolis, Antonio, additional, Armentano, Raffaele, additional, Giudetti, Anna Maria, additional, Vergara, Daniele, additional, Campiglia, Pietro, additional, Sardone, Rodolfo, additional, Curlo, Margherita, additional, Mastronardi, Mauro, additional, Petroni, Katia, additional, Tonelli, Chiara, additional, Santino, Angelo, additional, and Chieppa, Marcello, additional

Published
2022
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