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219 results on '"Gisselsson, David"'

1. Hallmark discoveries in the biology of Wilms tumour

Author

Perotti, Daniela, Williams, Richard D., Wegert, Jenny, Brzezinski, Jack, Maschietto, Mariana, Ciceri, Sara, Gisselsson, David, Gadd, Samantha, Walz, Amy L., Furtwaengler, Rhoikos, Drost, Jarno, Al-Saadi, Reem, Evageliou, Nicholas, Gooskens, Saskia L., Hong, Andrew L., Murphy, Andrew J., Ortiz, Michael V., O’Sullivan, Maureen J., Mullen, Elizabeth A., van den Heuvel-Eibrink, Marry M., Fernandez, Conrad V., Graf, Norbert, Grundy, Paul E., Geller, James I., Dome, Jeffrey S., Perlman, Elizabeth J., Gessler, Manfred, Huff, Vicki, and Pritchard-Jones, Kathy

Published
2024
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3. Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors—a nationwide, prospective Swedish study

Author

Tesi, Bianca, Robinson, Kristina Lagerstedt, Abel, Frida, Díaz de Ståhl, Teresita, Orrsjö, Sara, Poluha, Anna, Hellberg, Maria, Wessman, Sandra, Samuelsson, Sofie, Frisk, Tony, Vogt, Hartmut, Henning, Karin, Sabel, Magnus, Ek, Torben, Pal, Niklas, Nyman, Per, Giraud, Geraldine, Wille, Joakim, Pronk, Cornelis Jan, Norén-Nyström, Ulrika, Borssén, Magnus, Fili, Maria, Stålhammar, Gustav, Herold, Nikolas, Tettamanti, Giorgio, Maya-Gonzalez, Carolina, Arvidsson, Linda, Rosén, Anna, Ekholm, Katja, Kuchinskaya, Ekaterina, Hallbeck, Anna-Lotta, Nordling, Margareta, Palmebäck, Pia, Kogner, Per, Smoler, Gunilla Kanter, Lähteenmäki, Päivi, Fransson, Susanne, Martinsson, Tommy, Shamik, Alia, Mertens, Fredrik, Rosenquist, Richard, Wirta, Valtteri, Tham, Emma, Grillner, Pernilla, Sandgren, Johanna, Ljungman, Gustaf, Gisselsson, David, Taylan, Fulya, and Nordgren, Ann

Published
2024
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9. Implementing precision medicine in a regionally organized healthcare system in Sweden

Author

Fioretos, Thoas, Wirta, Valtteri, Cavelier, Lucia, Berglund, Eva, Friedman, Mikaela, Akhras, Michael, Botling, Johan, Ehrencrona, Hans, Engstrand, Lars, Helenius, Gisela, Fagerqvist, Therese, Gisselsson, David, Gruvberger-Saal, Sofia, Gyllensten, Ulf, Heidenblad, Markus, Höglund, Kina, Jacobsson, Bo, Johansson, Maria, Johansson, Åsa, Soller, Maria Johansson, Landström, Maréne, Larsson, Pär, Levin, Lars-Åke, Lindstrand, Anna, Lovmar, Lovisa, Lyander, Anna, Melin, Malin, Nordgren, Ann, Nordmark, Gunnel, Mölling, Paula, Palmqvist, Lars, Palmqvist, Richard, Repsilber, Dirk, Sikora, Per, Stenmark, Bianca, Söderkvist, Peter, Stranneheim, Henrik, Strid, Tobias, Wheelock, Craig E., Wadelius, Mia, Wedell, Anna, Edsjö, Anders, and Rosenquist, Richard

Published
2022
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10. The immune cell atlas of human neuroblastoma

Author

Verhoeven, Bronte Manouk, Mei, Shenglin, Olsen, Thale Kristin, Gustafsson, Karin, Valind, Anders, Lindström, Axel, Gisselsson, David, Fard, Shahrzad Shirazi, Hagerling, Catharina, Kharchenko, Peter V., Kogner, Per, Johnsen, John Inge, and Baryawno, Ninib

Published
2022
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16. Gradual transition towards anaplasia in Wilms tumor through tolerance to genetic damage

Author

Uno, Kaname, primary, Rastegar, Bahar, additional, Jansson, Caroline, additional, Durand, Geoffroy, additional, Valind, Anders, additional, Chattopadhyay, Subhayan, additional, Bertolotti, Alessia, additional, Ciceri, Sara, additional, Spreafico, Filippo, additional, Collini, Paola, additional, Perotti, Daniela, additional, Holmquist Mengelbier, Linda, additional, and Gisselsson, David, additional

Published
2023
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18. Hallmark discoveries in the biology of Wilms tumour

Author

Perotti, Daniela, primary, Williams, Richard D., additional, Wegert, Jenny, additional, Brzezinski, Jack, additional, Maschietto, Mariana, additional, Ciceri, Sara, additional, Gisselsson, David, additional, Gadd, Samantha, additional, Walz, Amy L., additional, Furtwaengler, Rhoikos, additional, Drost, Jarno, additional, Al-Saadi, Reem, additional, Evageliou, Nicholas, additional, Gooskens, Saskia L., additional, Hong, Andrew L., additional, Murphy, Andrew J., additional, Ortiz, Michael V., additional, O’Sullivan, Maureen J., additional, Mullen, Elizabeth A., additional, van den Heuvel-Eibrink, Marry M., additional, Fernandez, Conrad V., additional, Graf, Norbert, additional, Grundy, Paul E., additional, Geller, James I., additional, Dome, Jeffrey S., additional, Perlman, Elizabeth J., additional, Gessler, Manfred, additional, Huff, Vicki, additional, and Pritchard-Jones, Kathy, additional

Published
2023
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19. Table S3 from Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution

Author

Rastegar, Bahar, primary, Andersson, Natalie, primary, Petersson, Alexandra, primary, Karlsson, Jenny, primary, Chattopadhyay, Subhayan, primary, Valind, Anders, primary, Jansson, Caroline, primary, Durand, Geoffroy, primary, Romerius, Patrik, primary, Jirström, Karin, primary, Holmquist Mengelbier, Linda, primary, and Gisselsson, David, primary

Published
2023
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20. Figure S1 from Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution

Author

Rastegar, Bahar, primary, Andersson, Natalie, primary, Petersson, Alexandra, primary, Karlsson, Jenny, primary, Chattopadhyay, Subhayan, primary, Valind, Anders, primary, Jansson, Caroline, primary, Durand, Geoffroy, primary, Romerius, Patrik, primary, Jirström, Karin, primary, Holmquist Mengelbier, Linda, primary, and Gisselsson, David, primary

Published
2023
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21. Data from Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution

Author

Rastegar, Bahar, primary, Andersson, Natalie, primary, Petersson, Alexandra, primary, Karlsson, Jenny, primary, Chattopadhyay, Subhayan, primary, Valind, Anders, primary, Jansson, Caroline, primary, Durand, Geoffroy, primary, Romerius, Patrik, primary, Jirström, Karin, primary, Holmquist Mengelbier, Linda, primary, and Gisselsson, David, primary

Published
2023
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23. Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution

Author

Rastegar, Bahar, primary, Andersson, Natalie, additional, Petersson, Alexandra, additional, Karlsson, Jenny, additional, Chattopadhyay, Subhayan, additional, Valind, Anders, additional, Jansson, Caroline, additional, Durand, Geoffroy, additional, Romerius, Patrik, additional, Jirström, Karin, additional, Holmquist Mengelbier, Linda, additional, and Gisselsson, David, additional

Published
2023
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24. Data from Branching Copy-Number Evolution and Parallel Immune Profiles across the Regional Tumor Space of Resected Pancreatic Cancer

Author

Petersson, Alexandra, primary, Andersson, Natalie, primary, Hau, Sofie Olsson, primary, Eberhard, Jakob, primary, Karlsson, Jenny, primary, Chattopadhyay, Subhayan, primary, Valind, Anders, primary, Elebro, Jacob, primary, Nodin, Björn, primary, Leandersson, Karin, primary, Gisselsson, David, primary, and Jirström, Karin, primary

Published
2023
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25. Supplementary Data from Branching Copy-Number Evolution and Parallel Immune Profiles across the Regional Tumor Space of Resected Pancreatic Cancer

Author

Petersson, Alexandra, primary, Andersson, Natalie, primary, Hau, Sofie Olsson, primary, Eberhard, Jakob, primary, Karlsson, Jenny, primary, Chattopadhyay, Subhayan, primary, Valind, Anders, primary, Elebro, Jacob, primary, Nodin, Björn, primary, Leandersson, Karin, primary, Gisselsson, David, primary, and Jirström, Karin, primary

Published
2023
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26. Figure S2 from Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma

Author

Braekeveldt, Noémie, primary, von Stedingk, Kristoffer, primary, Fransson, Susanne, primary, Martinez-Monleon, Angela, primary, Lindgren, David, primary, Axelson, Håkan, primary, Levander, Fredrik, primary, Willforss, Jakob, primary, Hansson, Karin, primary, Øra, Ingrid, primary, Backman, Torbjörn, primary, Börjesson, Anna, primary, Beckman, Siv, primary, Esfandyari, Javanshir, primary, Berbegall, Ana P., primary, Noguera, Rosa, primary, Karlsson, Jenny, primary, Koster, Jan, primary, Martinsson, Tommy, primary, Gisselsson, David, primary, Påhlman, Sven, primary, and Bexell, Daniel, primary

Published
2023
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27. Supplementary table 6-7 from Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma

Author

Braekeveldt, Noémie, primary, von Stedingk, Kristoffer, primary, Fransson, Susanne, primary, Martinez-Monleon, Angela, primary, Lindgren, David, primary, Axelson, Håkan, primary, Levander, Fredrik, primary, Willforss, Jakob, primary, Hansson, Karin, primary, Øra, Ingrid, primary, Backman, Torbjörn, primary, Börjesson, Anna, primary, Beckman, Siv, primary, Esfandyari, Javanshir, primary, Berbegall, Ana P., primary, Noguera, Rosa, primary, Karlsson, Jenny, primary, Koster, Jan, primary, Martinsson, Tommy, primary, Gisselsson, David, primary, Påhlman, Sven, primary, and Bexell, Daniel, primary

Published
2023
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28. Data from Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma

Author

Braekeveldt, Noémie, primary, von Stedingk, Kristoffer, primary, Fransson, Susanne, primary, Martinez-Monleon, Angela, primary, Lindgren, David, primary, Axelson, Håkan, primary, Levander, Fredrik, primary, Willforss, Jakob, primary, Hansson, Karin, primary, Øra, Ingrid, primary, Backman, Torbjörn, primary, Börjesson, Anna, primary, Beckman, Siv, primary, Esfandyari, Javanshir, primary, Berbegall, Ana P., primary, Noguera, Rosa, primary, Karlsson, Jenny, primary, Koster, Jan, primary, Martinsson, Tommy, primary, Gisselsson, David, primary, Påhlman, Sven, primary, and Bexell, Daniel, primary

Published
2023
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29. Supplementary Methods from Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma

Author

Braekeveldt, Noémie, primary, von Stedingk, Kristoffer, primary, Fransson, Susanne, primary, Martinez-Monleon, Angela, primary, Lindgren, David, primary, Axelson, Håkan, primary, Levander, Fredrik, primary, Willforss, Jakob, primary, Hansson, Karin, primary, Øra, Ingrid, primary, Backman, Torbjörn, primary, Börjesson, Anna, primary, Beckman, Siv, primary, Esfandyari, Javanshir, primary, Berbegall, Ana P., primary, Noguera, Rosa, primary, Karlsson, Jenny, primary, Koster, Jan, primary, Martinsson, Tommy, primary, Gisselsson, David, primary, Påhlman, Sven, primary, and Bexell, Daniel, primary

Published
2023
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31. Supplementary table 3-5 from Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma

Author

Braekeveldt, Noémie, primary, von Stedingk, Kristoffer, primary, Fransson, Susanne, primary, Martinez-Monleon, Angela, primary, Lindgren, David, primary, Axelson, Håkan, primary, Levander, Fredrik, primary, Willforss, Jakob, primary, Hansson, Karin, primary, Øra, Ingrid, primary, Backman, Torbjörn, primary, Börjesson, Anna, primary, Beckman, Siv, primary, Esfandyari, Javanshir, primary, Berbegall, Ana P., primary, Noguera, Rosa, primary, Karlsson, Jenny, primary, Koster, Jan, primary, Martinsson, Tommy, primary, Gisselsson, David, primary, Påhlman, Sven, primary, and Bexell, Daniel, primary

Published
2023
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32. Supplementary Figure S1 from Distinct Mitotic Segregation Errors Mediate Chromosomal Instability in Aggressive Urothelial Cancers

Author

Jin, Yuesheng, primary, Stewénius, Ylva, primary, Lindgren, David, primary, Frigyesi, Attila, primary, Calcagnile, Olga, primary, Jonson, Tord, primary, Edqvist, Anna, primary, Larsson, Nina, primary, Lundberg, Lena Maria, primary, Chebil, Gunilla, primary, Liedberg, Fredrik, primary, Gudjonsson, Sigurdur, primary, Månsson, Wiking, primary, Höglund, Mattias, primary, and Gisselsson, David, primary

Published
2023
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33. Supplementary table 8-14 from Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma

Author

Braekeveldt, Noémie, primary, von Stedingk, Kristoffer, primary, Fransson, Susanne, primary, Martinez-Monleon, Angela, primary, Lindgren, David, primary, Axelson, Håkan, primary, Levander, Fredrik, primary, Willforss, Jakob, primary, Hansson, Karin, primary, Øra, Ingrid, primary, Backman, Torbjörn, primary, Börjesson, Anna, primary, Beckman, Siv, primary, Esfandyari, Javanshir, primary, Berbegall, Ana P., primary, Noguera, Rosa, primary, Karlsson, Jenny, primary, Koster, Jan, primary, Martinsson, Tommy, primary, Gisselsson, David, primary, Påhlman, Sven, primary, and Bexell, Daniel, primary

Published
2023
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35. Supplementary Tables S1-S2 from Distinct Mitotic Segregation Errors Mediate Chromosomal Instability in Aggressive Urothelial Cancers

Author

Jin, Yuesheng, primary, Stewénius, Ylva, primary, Lindgren, David, primary, Frigyesi, Attila, primary, Calcagnile, Olga, primary, Jonson, Tord, primary, Edqvist, Anna, primary, Larsson, Nina, primary, Lundberg, Lena Maria, primary, Chebil, Gunilla, primary, Liedberg, Fredrik, primary, Gudjonsson, Sigurdur, primary, Månsson, Wiking, primary, Höglund, Mattias, primary, and Gisselsson, David, primary

Published
2023
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36. Supplementary table 1-2 from Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma

Author

Braekeveldt, Noémie, primary, von Stedingk, Kristoffer, primary, Fransson, Susanne, primary, Martinez-Monleon, Angela, primary, Lindgren, David, primary, Axelson, Håkan, primary, Levander, Fredrik, primary, Willforss, Jakob, primary, Hansson, Karin, primary, Øra, Ingrid, primary, Backman, Torbjörn, primary, Börjesson, Anna, primary, Beckman, Siv, primary, Esfandyari, Javanshir, primary, Berbegall, Ana P., primary, Noguera, Rosa, primary, Karlsson, Jenny, primary, Koster, Jan, primary, Martinsson, Tommy, primary, Gisselsson, David, primary, Påhlman, Sven, primary, and Bexell, Daniel, primary

Published
2023
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37. Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy

Author

Valind, Anders, primary, Verhoeven, Bronte Manouk, additional, Enoksson, Jens, additional, Karlsson, Jenny, additional, Christensson, Gustav, additional, Mañas, Adriana, additional, Aaltonen, Kristina, additional, Jansson, Caroline, additional, Bexell, Daniel, additional, Baryawno, Ninib, additional, Gisselsson, David, additional, and Hagerling, Catharina, additional

Published
2023
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38. Building a precision medicine infrastructure at a national level : The Swedish experience

Author

Edsjö, Anders, Lindstrand, Anna, Gisselsson, David, Mölling, Paula, Friedman, Mikaela, Cavelier, Lucia, Johansson, Maria, Ehrencrona, Hans, Fagerqvist, Therese, Strid, Tobias, Lovmar, Lovisa, Jacobsson, Bo, Johansson, Åsa, Engstrand, Lars, Wheelock, Craig E., Sikora, Per, Wirta, Valtteri, Fioretos, Thoas, Rosenquist, Richard, Edsjö, Anders, Lindstrand, Anna, Gisselsson, David, Mölling, Paula, Friedman, Mikaela, Cavelier, Lucia, Johansson, Maria, Ehrencrona, Hans, Fagerqvist, Therese, Strid, Tobias, Lovmar, Lovisa, Jacobsson, Bo, Johansson, Åsa, Engstrand, Lars, Wheelock, Craig E., Sikora, Per, Wirta, Valtteri, Fioretos, Thoas, and Rosenquist, Richard

Abstract

Precision medicine has the potential to transform healthcare by moving from one-size-fits-all to personalised treatment and care. This transition has been greatly facilitated through new high-throughput sequencing technologies that can provide the unique molecular profile of each individual patient, along with the rapid development of targeted therapies directed to the Achilles heels of each disease. To implement precision medicine approaches in healthcare, many countries have adopted national strategies and initiated genomic/precision medicine initiatives to provide equal access to all citizens. In other countries, such as Sweden, this has proven more difficult due to regionally organised healthcare. Using a bottom-up approach, key stakeholders from academia, healthcare, industry and patient organisations joined forces and formed Genomic Medicine Sweden (GMS), a national infrastructure for the implementation of precision medicine across the country. To achieve this, Genomic Medicine Centres have been established to provide regionally distributed genomic services, and a national informatics infrastructure has been built to allow secure data handling and sharing. GMS has a broad scope focusing on rare diseases, cancer, pharmacogenomics, infectious diseases and complex diseases, while also providing expertise in informatics, ethical and legal issues, health economy, industry collaboration and education. In this review, we summarise our experience in building a national infrastructure for precision medicine. We also provide key examples how precision medicine already has been successfully implemented within our focus areas. Finally, we bring up challenges and opportunities associated with precision medicine implementation, the importance of international collaboration, as well as the future perspective in the field of precision medicine.

Published
2023
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39. Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With Cancer

Author

Wadensten, Elisabeth, Wessman, Sandra, Abel, Frida, Diaz De Ståhl, Teresita, Tesi, Bianca, Orsmark Pietras, Christina, Arvidsson, Linda, Taylan, Fulya, Fransson, Susanne, Vogt, Hartmut, Poluha, Anna, Pradhananga, Sailendra, Hellberg, Maria, Lagerstedt-Robinson, Kristina, Raj Somarajan, Praveen, Samuelsson, Sofie, Orrsjö, Sara, Maqbool, Khurram, Henning, Karin, Strid, Tobias, Ek, Torben, Fagman, Henrik, Olsson Bontell, Thomas, Martinsson, Tommy, Puls, Florian, Kogner, Per, Wirta, Valtteri, Pronk, Cornelis Jan, Wille, Joakim, Rosenquist, Richard, Nistér, Monica, Mertens, Fredrik, Sabel, Magnus, Norén-Nyström, Ulrika, Grillner, Pernilla, Nordgren, Ann, Ljungman, Gustaf, Sandgren, Johanna, Gisselsson, David, Wadensten, Elisabeth, Wessman, Sandra, Abel, Frida, Diaz De Ståhl, Teresita, Tesi, Bianca, Orsmark Pietras, Christina, Arvidsson, Linda, Taylan, Fulya, Fransson, Susanne, Vogt, Hartmut, Poluha, Anna, Pradhananga, Sailendra, Hellberg, Maria, Lagerstedt-Robinson, Kristina, Raj Somarajan, Praveen, Samuelsson, Sofie, Orrsjö, Sara, Maqbool, Khurram, Henning, Karin, Strid, Tobias, Ek, Torben, Fagman, Henrik, Olsson Bontell, Thomas, Martinsson, Tommy, Puls, Florian, Kogner, Per, Wirta, Valtteri, Pronk, Cornelis Jan, Wille, Joakim, Rosenquist, Richard, Nistér, Monica, Mertens, Fredrik, Sabel, Magnus, Norén-Nyström, Ulrika, Grillner, Pernilla, Nordgren, Ann, Ljungman, Gustaf, Sandgren, Johanna, and Gisselsson, David

Abstract

Purpose: Several studies have indicated that broad genomic characterization of childhood cancer provides diagnostically and/or therapeutically relevant information in selected high-risk cases. However, the extent to which such characterization offers clinically actionable data in a prospective broadly inclusive setting remains largely unexplored. Methods: We implemented prospective whole-genome sequencing (WGS) of tumor and germline, complemented by whole-transcriptome sequencing (RNA-Seq) for all children diagnosed with a primary or relapsed solid malignancy in Sweden. Multidisciplinary molecular tumor boards were set up to integrate genomic data in the clinical decision process along with a medicolegal framework enabling secondary use of sequencing data for research purposes. Results: During the study's first 14 months, 118 solid tumors from 117 patients were subjected to WGS, with complementary RNA-Seq for fusion gene detection in 52 tumors. There was no significant geographic bias in patient enrollment, and the included tumor types reflected the annual national incidence of pediatric solid tumor types. Of the 112 tumors with somatic mutations, 106 (95%) exhibited alterations with a clear clinical correlation. In 46 of 118 tumors (39%), sequencing only corroborated histopathological diagnoses, while in 59 cases (50%), it contributed to additional subclassification or detection of prognostic markers. Potential treatment targets were found in 31 patients (26%), most commonly ALK mutations/fusions (n = 4), RAS/RAF/MEK/ERK pathway mutations (n = 14), FGFR1 mutations/fusions (n = 5), IDH1 mutations (n = 2), and NTRK2 gene fusions (n = 2). In one patient, the tumor diagnosis was revised based on sequencing. Clinically relevant germline variants were detected in 8 of 94 patients (8.5%). Conclusion: Up-front, large-scale genomic characterization of pediatric solid malignancies provides diagnostically valuable data in the majority of patients also in a largely unselected, Funding Agencies|Swedish Childhood Cancer Fund; Swedish Government; Swedish Research Council [2018-05661]

Published
2023
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41. Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

Author

Mañas, Adriana, Aaltonen, Kristina, Andersson, Natalie, Hansson, Karin, Adamska, Aleksandra, Seger, Alexandra, Yasui, Hiroaki, van den Bos, Hilda, Radke, Katarzyna, Esfandyari, Javanshir, Bhave, Madhura Satish, Karlsson, Jenny, Spierings, Diana, Foijer, Floris, Gisselsson, David, Bexell, Daniel, Stem Cell Aging Leukemia and Lymphoma (SALL), Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)

Abstract

Chemotherapy resistance and relapses are common in high-risk neuroblastoma (NB). Here, we developed a clinically relevant in vivo treatment protocol mimicking the first-line five-chemotherapy treatment regimen of high-risk NB and applied this protocol to mice with MYCN-amplified NB patient-derived xenografts (PDXs). Genomic and transcriptomic analyses were used to reveal NB chemoresistance mechanisms. Intrinsic resistance was associated with high genetic diversity and an embryonic phenotype. Relapsed NB with acquired resistance showed a decreased adrenergic phenotype and an enhanced immature mesenchymal-like phenotype, resembling multipotent Schwann cell precursors. NBs with a favorable treatment response presented a lineage-committed adrenergic phenotype similar to normal neuroblasts. Novel integrated phenotypic gene signatures reflected treatment response and patient prognosis. NB organoids established from relapsed PDX tumors retained drug resistance, tumorigenicity, and transcriptional cell states. This work sheds light on the mechanisms of NB chemotherapy response and emphasizes the importance of transcriptional cell states in chemoresistance.

Published
2022

42. Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma

Author

Gisselsson, David, primary, Karlsson, Jenny, additional, Yasui, Hiroaki, additional, Manas, Adriana, additional, Andersson, Natalie, additional, Hansson, Karin, additional, Aaltonen, Kristina, additional, Jansson, Caroline, additional, Durand, Geoffroy, additional, Yang, Minjun, additional, Chattopadhyay, Subhayan, additional, Paulsson, Kajsa, additional, Spierings, Diana, additional, Foijer, Floris, additional, Valind, Anders, additional, and Bexell, Daniel, additional

Published
2022
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44. Trailblazing precision medicine in Europe: A joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany

Author

Stenzinger, Albrecht, primary, Edsjö, Anders, additional, Ploeger, Carolin, additional, Friedman, Mikaela, additional, Fröhling, Stefan, additional, Wirta, Valtteri, additional, Seufferlein, Thomas, additional, Botling, Johan, additional, Duyster, Justus, additional, Akhras, Michael, additional, Thimme, Robert, additional, Fioretos, Thoas, additional, Bitzer, Michael, additional, Cavelier, Lucia, additional, Schirmacher, Peter, additional, Malek, Nisar, additional, Rosenquist, Richard, additional, Lindstrand, Anna, additional, Wedell, Anna, additional, Gisselsson, David, additional, Melén, Erik, additional, Helenius, Gisela, additional, Ehrencrona, Hans, additional, Engstrand, Lars, additional, Palmqvist, Lars, additional, Levin, Lars-Åke, additional, Lovmar, Lovisa, additional, Landström, Maréne, additional, Hallbeck, Martin, additional, Wadelius, Mia, additional, Sikora, Per, additional, Beer, Ambros J., additional, Illert, Anna L., additional, Budczies, Jan, additional, Nikolaou, Konstantin, additional, Kohlbacher, Oliver, additional, Horak, Peter, additional, Kuhn, Peter, additional, Schroeder, Christopher, additional, Boerries, Melanie, additional, Lassmann, Silke, additional, and Gaidzik, Verena I., additional

Published
2022
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46. Evolutionary unpredictability in cancer model system

Author

Chattopadhyay, Subhayan, primary, Karlsson, Jenny, additional, Mañas, Adriana, additional, Kanzaki, Ryu, additional, Fredlund, Elina, additional, Murphy, Andrew J., additional, Morton, Christopher L., additional, Andersson, Natalie, additional, Woolard, Mary A., additional, Hansson, Karin, additional, Radke, Katarzyna, additional, Davidhoff, Andrew M., additional, Mohlin, Sofie, additional, Pietras, Kristian, additional, Bexell, Daniel, additional, and Gisselsson, David, additional

Published
2022
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