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Your search keyword '"Gimber, Niclas"' showing total 9 results
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9 results on '"Gimber, Niclas"'

1. Lack of Laminar Shear Stress Facilitates the Endothelial Uptake of Very Small Superparamagnetic Iron Oxide Nanoparticles by Modulating the Endothelial Surface Layer

Author

Twamley, Shailey, primary, Gimber, Niclas, additional, Sánchez-Ibarra, Héctor, additional, Christaller, Tobias, additional, Isakzai, Victoria, additional, Kratz, Harald, additional, Mitra, Ronodeep, additional, Kampen, Lena, additional, Stach, Anke, additional, Heilmann, Heike, additional, Söhl-Kielczynski, Berit, additional, Ebong, Eno, additional, Schmoranzer, Jan, additional, Münster-Wandowski, Agnieszka, additional, and Ludwig, Antje, additional

Published
2024
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2. Phosphorylation of PLPPR3 membrane proteins as signaling integrator at neuronal synapses

Author

Kroon, Cristina, primary, Bareesel, Shannon, additional, Kirchner, Marieluise, additional, Gimber, Niclas, additional, Ranti, Dimitra, additional, Brosig, Annika, additional, Textoris-Taube, Kathrin, additional, Zolnik, Timothy A., additional, Mertins, Philipp, additional, Schmoranzer, Jan, additional, Leondaritis, George, additional, and Eickholt, Britta J., additional

Published
2024
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3. ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection

Author

Bredow, Clara, primary, Thery, Fabien, additional, Wirth, Eva Katrin, additional, Ochs, Sarah, additional, Kespohl, Meike, additional, Kleinau, Gunnar, additional, Kelm, Nicolas, additional, Gimber, Niclas, additional, Schmoranzer, Jan, additional, Voss, Martin, additional, Klingel, Karin, additional, Spranger, Joachim, additional, Renko, Kostja, additional, Ralser, Markus, additional, Mülleder, Michael, additional, Heuser, Arnd, additional, Knobeloch, Klaus-Peter, additional, Scheerer, Patrick, additional, Kirwan, Jennifer, additional, Brüning, Ulrike, additional, Berndt, Nikolaus, additional, Impens, Francis, additional, and Beling, Antje, additional

Published
2024
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5. The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses

Author

Schmerl, Bettina, primary, Gimber, Niclas, additional, Kuropka, Benno, additional, Stumpf, Alexander, additional, Rentsch, Jakob, additional, Kunde, Stella-Amrei, additional, von Sivers, Judith, additional, Ewers, Helge, additional, Schmitz, Dietmar, additional, Freund, Christian, additional, Schmoranzer, Jan, additional, Rademacher, Nils, additional, and Shoichet, Sarah A., additional

Published
2022
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7. A cytosolic disulfide bridge‐supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A

Author

Voss, Martin, primary, Kleinau, Gunnar, additional, Gimber, Niclas, additional, Janek, Katharina, additional, Bredow, Clara, additional, Thery, Fabien, additional, Impens, Francis, additional, Schmoranzer, Jan, additional, Scheerer, Patrick, additional, Kloetzel, Peter‐Michael, additional, and Beling, Antje, additional

Published
2022
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9. The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses.

Author

Schmerl, Bettina, Gimber, Niclas, Kuropka, Benno, Stumpf, Alexander, Rentsch, Jakob, Kunde, Stella-Amrei, von Sivers, Judith, Ewers, Helge, Schmitz, Dietmar, Freund, Christian, Schmoranzer, Jan, Rademacher, Nils, and Shoichet, Sarah A.

Subjects
*SCAFFOLD proteins, *DENDRITIC spines, *CELL adhesion molecules, *SYNAPSES, *MEMBRANE proteins, *NEURAL transmission
Abstract

Recent advances in imaging technology have highlighted that scaffold proteins and receptors are arranged in subsynaptic nanodomains. The synaptic membrane-associated guanylate kinase (MAGUK) scaffold protein membrane protein palmitoylated 2 (MPP2) is a component of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor–associated protein complexes and also binds to the synaptic cell adhesion molecule SynCAM 1. Using superresolution imaging, we show that—like SynCAM 1—MPP2 is situated at the periphery of the postsynaptic density (PSD). In order to explore MPP2-associated protein complexes, we used a quantitative comparative proteomics approach and identified multiple γ-aminobutyric acid (GABA)A receptor subunits among novel synaptic MPP2 interactors. In line with a scaffold function for MPP2 in the assembly and/or modulation of intact GABAA receptors, manipulating MPP2 expression had effects on inhibitory synaptic transmission. We further show that GABAA receptors are found together with MPP2 in a subset of dendritic spines and thus highlight MPP2 as a scaffold that serves as an adaptor molecule, linking peripheral synaptic elements critical for inhibitory regulation to central structures at the PSD of glutamatergic synapses. This study shows that the MAGUK scaffold protein MPP2 is located at the periphery of postsynaptic densities in excitatory neurons, where it interacts with GABA-A receptors, thereby serving as a functional adaptor that links excitatory and inhibitory components of synaptic transmission at glutamatergic synapses. [ABSTRACT FROM AUTHOR]

Published
2022
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