16 results on '"Gilbert, Edmund"'
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2. Donor genetic burden for cerebrovascular risk and kidney transplant outcome
- Author
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Collins, Kane E., Gilbert, Edmund, Mauduit, Vincent, Benson, Katherine A., Elhassan, Elhussein A. E., O’Seaghdha, Conall, Hill, Claire, McKnight, Amy Jayne, Maxwell, Alexander P., van der Most, Peter J., de Borst, Martin H., Guan, Weihua, Jacobson, Pamala A., Israni, Ajay K., Keating, Brendan J., Lord, Graham M., Markkinen, Salla, Helanterä, Ilkka, Hyvärinen, Kati, Partanen, Jukka, Madden, Stephen F., Limou, Sophie, Cavalleri, Gianpiero L., and Conlon, Peter J.
- Published
- 2024
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3. Corroborating written history with ancient DNA: The case of the Well-man described in an Old Norse saga
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Ellegaard, Martin R., Ebenesersdóttir, S. Sunna, Moore, Kristjan H.S., Petersén, Anna, Vågene, Åshild J., Bieker, Vanessa C., Denham, Sean D., Cavalleri, Gianpiero L., Gilbert, Edmund, Werge, Thomas, Hansen, Thomas F., Kockum, Ingrid, Alfredsson, Lars, Olsson, Tomas, Hovig, Eivind, Gilbert, M. Thomas P., Stefánsson, Kári, Stenøien, Hans K., Helgason, Agnar, and Martin, Michael D.
- Published
- 2024
- Full Text
- View/download PDF
4. The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago
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Gilbert, Edmund, Zurel, Heather, MacMillan, Margaret E., Demiriz, Sedat, Mirhendi, Sadra, Merrigan, Michael, O’Reilly, Seamus, Molloy, Anne M., Brody, Lawrence C., Bodmer, Walter, Leach, Richard A., Scott, Roderick E. M., Mugford, Gerald, Randhawa, Ranjit, Stephens, J. Claiborne, Symington, Alison L., Cavalleri, Gianpiero L., and Phillips, Michael S.
- Published
- 2023
- Full Text
- View/download PDF
5. Revealing the recent demographic history of Europe via haplotype sharing in the UK Biobank
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Gilbert, Edmund, Shanmugam, Ashwini, and Cavalleri, Gianpiero L.
- Published
- 2022
6. The genetic history of Scandinavia from the Roman Iron Age to the present
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Rodríguez-Varela, Ricardo, Moore, Kristjan H.S., Ebenesersdóttir, S. Sunna, Kilinc, Gulsah Merve, Kjellström, Anna, Papmehl-Dufay, Ludvig, Alfsdotter, Clara, Berglund, Birgitta, Alrawi, Loey, Kashuba, Natalija, Sobrado, Verónica, Lagerholm, Vendela Kempe, Gilbert, Edmund, Cavalleri, Gianpiero L., Hovig, Eivind, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Hansen, Thomas F., Werge, Thomas, Munters, Arielle R., Bernhardsson, Carolina, Skar, Birgitte, Christophersen, Axel, Turner-Walker, Gordon, Gopalakrishnan, Shyam, Daskalaki, Eva, Omrak, Ayça, Pérez-Ramallo, Patxi, Skoglund, Pontus, Girdland-Flink, Linus, Gunnarsson, Fredrik, Hedenstierna-Jonson, Charlotte, Gilbert, M. Thomas P., Lidén, Kerstin, Jakobsson, Mattias, Einarsson, Lars, Victor, Helena, Krzewińska, Maja, Zachrisson, Torun, Storå, Jan, Stefánsson, Kári, Helgason, Agnar, and Götherström, Anders
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- 2023
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7. A genetic perspective on the recent demographic history of Ireland and Britain
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Shanmugam, Ashwini, primary, Merrigan, Michael, additional, O’Reilly, Seamus, additional, Molloy, Anne M., additional, Brody, Lawrence, additional, Hardiman, Orla, additional, McLaughlin, Russell, additional, Cavalleri, Gianpiero L., additional, Byrne, Ross, additional, and Gilbert, Edmund, additional
- Published
- 2024
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8. The genetic history of Scandinavia from the Roman Iron Age to the present
- Author
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Especialidades médico-quirúrgicas, Medikuntza eta kirurgia espezialitateak, Rodríguez Varela, Ricardo, Moore, Kristjan H. S., Ebenesersdottir, S. Sunna, Kilinc, Gulsah Merve, Kjellström, Anna, Papmehl-Dufay, Ludvig, Alfsdotter, Clara, Berglund, Birgitta, Alrawi, Loey, Kashuba, Natalija, Sobrado, Verónica, Lagerholm, Vendela Kempe, Gilbert, Edmund, Cavalleri, Gianpiero L., Hovig, Eivind, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Hansen, Thomas F., Werge, Thomas, Munters, Arielle R., Bernhardsson, Carolina, Skar, Birgitte, Christophersen, Axel, Turner-Walker, Gordon, Gopalakrishnan, Shyam, Daskalaki, Eva, Omrak, Ayca, Pérez Ramallo, Patxi, Skoglund, Pontus, Girdland-Flink, Linus, Gunnarsson, Fredrik, Hedenstierna-Jonson, Charlotte, Gilbert, M. Thomas P., Liden, Kerstin, Jakobsson, Mattias, Einarsson, Lars, Victor, Helena, Krzewinska, Maja, Zachrisson, Torun, Stora, Jan, Stefansson, Kari, Helgason, Agnar, Götherström, Anders, Especialidades médico-quirúrgicas, Medikuntza eta kirurgia espezialitateak, Rodríguez Varela, Ricardo, Moore, Kristjan H. S., Ebenesersdottir, S. Sunna, Kilinc, Gulsah Merve, Kjellström, Anna, Papmehl-Dufay, Ludvig, Alfsdotter, Clara, Berglund, Birgitta, Alrawi, Loey, Kashuba, Natalija, Sobrado, Verónica, Lagerholm, Vendela Kempe, Gilbert, Edmund, Cavalleri, Gianpiero L., Hovig, Eivind, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Hansen, Thomas F., Werge, Thomas, Munters, Arielle R., Bernhardsson, Carolina, Skar, Birgitte, Christophersen, Axel, Turner-Walker, Gordon, Gopalakrishnan, Shyam, Daskalaki, Eva, Omrak, Ayca, Pérez Ramallo, Patxi, Skoglund, Pontus, Girdland-Flink, Linus, Gunnarsson, Fredrik, Hedenstierna-Jonson, Charlotte, Gilbert, M. Thomas P., Liden, Kerstin, Jakobsson, Mattias, Einarsson, Lars, Victor, Helena, Krzewinska, Maja, Zachrisson, Torun, Stora, Jan, Stefansson, Kari, Helgason, Agnar, and Götherström, Anders
- Abstract
Scandinavia spanning the Iron Age to the present, based on 48 new and 249 published ancient genomes and genotypes from 16,638 modern individuals. We find regional variation in the timing and magnitude of gene flow from three sources: the eastern Baltic, the British-Irish Isles, and southern Europe. British-Irish ancestry was widespread in Scandinavia from the Viking period, whereas eastern Baltic ancestry is more localized to Gotland and central Sweden. In some regions, a drop in current levels of external ancestry suggests that ancient immigrants contributed proportionately less to the modern Scandinavian gene pool than indicated by the ancestry of genomes from the Viking and Medieval periods. Finally, we show that a north-south genetic cline that characterizes modern Scandinavians is mainly due to the differential levels of Uralic ancestry and that this cline existed in the Viking Age and possibly earlier.
- Published
- 2023
9. The population genomic legacy of the second plague pandemic
- Author
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Gopalakrishnan, Shyam, primary, Ebenesersdóttir, S. Sunna, additional, Lundstrøm, Inge K.C., additional, Turner-Walker, Gordon, additional, Moore, Kristjan H.S., additional, Luisi, Pierre, additional, Margaryan, Ashot, additional, Martin, Michael D., additional, Ellegaard, Martin Rene, additional, Magnússon, Ólafur þ., additional, Sigurðsson, Ásgeir, additional, Snorradóttir, Steinunn, additional, Magnúsdóttir, Droplaug N., additional, Laffoon, Jason E., additional, van Dorp, Lucy, additional, Liu, Xiaodong, additional, Moltke, Ida, additional, Ávila-Arcos, María C., additional, Schraiber, Joshua G., additional, Rasmussen, Simon, additional, Juan, David, additional, Gelabert, Pere, additional, de-Dios, Toni, additional, Fotakis, Anna K., additional, Iraeta-Orbegozo, Miren, additional, Vågene, Åshild J., additional, Denham, Sean Dexter, additional, Christophersen, Axel, additional, Stenøien, Hans K., additional, Vieira, Filipe G., additional, Liu, Shanlin, additional, Günther, Torsten, additional, Kivisild, Toomas, additional, Moseng, Ole Georg, additional, Skar, Birgitte, additional, Cheung, Christina, additional, Sandoval-Velasco, Marcela, additional, Wales, Nathan, additional, Schroeder, Hannes, additional, Campos, Paula F., additional, Guðmundsdóttir, Valdís B., additional, Sicheritz-Ponten, Thomas, additional, Petersen, Bent, additional, Halgunset, Jostein, additional, Gilbert, Edmund, additional, Cavalleri, Gianpiero L., additional, Hovig, Eivind, additional, Kockum, Ingrid, additional, Olsson, Tomas, additional, Alfredsson, Lars, additional, Hansen, Thomas F., additional, Werge, Thomas, additional, Willerslev, Eske, additional, Balloux, Francois, additional, Marques-Bonet, Tomas, additional, Lalueza-Fox, Carles, additional, Nielsen, Rasmus, additional, Stefánsson, Kári, additional, Helgason, Agnar, additional, and Gilbert, M. Thomas P., additional
- Published
- 2022
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10. Population history and genome wide association studies of birth weight in a native high altitude Ladakhi population
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Bhandari, Sushil, primary, Dolma, Padma, additional, Mukerji, Mitali, additional, Prasher, Bhavana, additional, Montgomery, Hugh, additional, Kular, Dalvir, additional, Jain, Vandana, additional, Dadhwal, Vatsla, additional, Williams, David J., additional, Bhattacharyaa, Aniket, additional, Gilbert, Edmund, additional, Cavalleri, Gianpiero L., additional, and Hillman, Sara L., additional
- Published
- 2022
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11. Characterization of the Y Chromosome in Newfoundland and Labrador: Evidence of a Founder Effect
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Zurel, Heather, primary, Bhérer, Claude, additional, Batten, Ryan, additional, MacMillan, Margaret E., additional, Demiriz, Sedat, additional, Mirhendi, Sadra, additional, Gilbert, Edmund, additional, Cavalleri, Gianpiero L., additional, Leach, Richard A., additional, Scott, Roderick E. M., additional, Mugford, Gerald, additional, Randhawa, Ranjit, additional, Symington, Alison L., additional, Stephens, J. Claiborne, additional, and Phillips, Michael S., additional
- Published
- 2022
- Full Text
- View/download PDF
12. The population genomic legacy of the second plague pandemic
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Gopalakrishnan, Shyam, Ebenesersdottir, S. Sunna, Lundström, Inge K. C., Turner-Walker, Gordon, Moore, Kristjan H. S., Luisi, Pierre, Margaryan, Ashot, Martin, Michael D., Ellegaard, Martin Rene, Magnusson, Olafur P., Sigurosson, Asgeir, Snorradottir, Steinunn, Magnusdottir, Droplaug N., Laffoon, Jason E., van Dorp, Lucy, Liu, Xiaodong, Moltke, Ida, Avila-Arcos, Maria C., Schraiber, Joshua G., Rasmussen, Simon, Juan, David, Gelabert, Pere, de-Dios, Toni, Fotakis, Anna K., Iraeta-Orbegozo, Miren, Vågene, Åshild J., Denham, Sean Dexter, Christophersen, Axel, Stenøien, Hans K., Vieira, Filipe G., Liu, Shanlin, Günther, Torsten, Kivisild, Toomas, Moseng, Ole Georg, Skar, Birgitte, Cheung, Christina, Sandoval-Velasco, Marcela, Wales, Nathan, Schroeder, Hannes, Campos, Paula F., Guomundsdottir, Valdis B., Sicheritz-Ponten, Thomas, Peterson, Bent, Halgunset, Jostein, Gilbert, Edmund, Cavalleri, Gianpiero L., Hovig, Eivind, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Hansen, Thomas F., Werge, Thomas, Willerslev, Eske, Balloux, Francois, Marques-Bonet, Tomas, Lalueza-Fox, Carles, Nielsen, Rasmus, Stefansson, Kari, Holgason, Agnar, Gilbert, M. Thomas P., Gopalakrishnan, Shyam, Ebenesersdottir, S. Sunna, Lundström, Inge K. C., Turner-Walker, Gordon, Moore, Kristjan H. S., Luisi, Pierre, Margaryan, Ashot, Martin, Michael D., Ellegaard, Martin Rene, Magnusson, Olafur P., Sigurosson, Asgeir, Snorradottir, Steinunn, Magnusdottir, Droplaug N., Laffoon, Jason E., van Dorp, Lucy, Liu, Xiaodong, Moltke, Ida, Avila-Arcos, Maria C., Schraiber, Joshua G., Rasmussen, Simon, Juan, David, Gelabert, Pere, de-Dios, Toni, Fotakis, Anna K., Iraeta-Orbegozo, Miren, Vågene, Åshild J., Denham, Sean Dexter, Christophersen, Axel, Stenøien, Hans K., Vieira, Filipe G., Liu, Shanlin, Günther, Torsten, Kivisild, Toomas, Moseng, Ole Georg, Skar, Birgitte, Cheung, Christina, Sandoval-Velasco, Marcela, Wales, Nathan, Schroeder, Hannes, Campos, Paula F., Guomundsdottir, Valdis B., Sicheritz-Ponten, Thomas, Peterson, Bent, Halgunset, Jostein, Gilbert, Edmund, Cavalleri, Gianpiero L., Hovig, Eivind, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Hansen, Thomas F., Werge, Thomas, Willerslev, Eske, Balloux, Francois, Marques-Bonet, Tomas, Lalueza-Fox, Carles, Nielsen, Rasmus, Stefansson, Kari, Holgason, Agnar, and Gilbert, M. Thomas P.
- Abstract
Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned for over 300 years, with typical village and town mortality estimated at 10%–40%.1 It is assumed that this high mortality affected the gene pools of these populations. First, local population crashes reduced genetic diversity. Second, a change in frequency is expected for sequence variants that may have affected survival or susceptibility to the etiologic agent (Yersinia pestis).2 Third, mass mortality might alter the local gene pools through its impact on subsequent migration patterns. We explored these factors using the Norwegian city of Trondheim as a model, by sequencing 54 genomes spanning three time periods: (1) prior to the plague striking Trondheim in 1,349 CE, (2) the 17th–19th century, and (3) the present. We find that the pandemic period shaped the gene pool by reducing long distance immigration, in particular from the British Isles, and inducing a bottleneck that reduced genetic diversity. Although we also observe an excess of large FST values at multiple loci in the genome, these are shaped by reference biases introduced by mapping our relatively low genome coverage degraded DNA to the reference genome. This implies that attempts to detect selection using ancient DNA (aDNA) datasets that vary by read length and depth of sequencing coverage may be particularly challenging until methods have been developed to account for the impact of differential reference bias on test statistics.
- Published
- 2022
- Full Text
- View/download PDF
13. The population genomic legacy of the second plague pandemic
- Author
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Carlsberg Foundation, Danish National Research Foundation, Lundbeck Foundation, European Research Council, Research Council of Norway, Science Foundation Ireland, Gopalakrishnan, Shyam, Ebenesersdóttir, Sigríður Sunna, Lundstrøm, Inge K.C., Turner-Walker, Gordon, Moore, Kristjan H.S., Luisi, Pierre, Margaryan, Ashot, Martin, Michael D., Ellegaard, Martin Rene, Magnusson, Olafur þ., Sigurðsson, Ásgeir, Snorradóttir, Steinunn, Magnúsdóttir, Droplaug N., Laffoon, Jason, van Dorp, Lucy, Liu, Xiaodong, Moltke, Ida, Ávila-Arcos, María C., Schraiber, Joshua G., Rasmussen,Simon, Juan, David, Gelabert, Pere, De-Dios, Toni, Fotakis, Anna K., Iraeta-Orbegozo, Miren, Vågene, Åshild J., Dexter Denham, Sean, Christophersen, Axel, Stenøien, Hans K., Vieira, Filipe Garrett, Liu, Shanlin, Günther, Torsten, Kivisild, Toomas, Moseng, Ole Georg, Skar, Birgitte, Cheung, Christina, Sandoval-Velasco, Marcela, Wales, Nathan, Schroeder, Hannes, Campos, Paula F., Guðmundsdóttir, Valdís B., Sicheritz-Ponten, Thomas, Petersen, Bent, Halgunset, Jostein, Gilbert, Edmund, Cavalleri, Gianpiero L., Hovig, Eivind, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Hansen, Thomas F., Werge, Thomas, Willerslev, Eske, Balloux, François, Marqués-Bonet, Tomàs, Lalueza-Fox, Carles, Nielsen, Rasmus, Stefánsson, Kári, Helgason, Agnar, Gilbert, M. Thomas P., Carlsberg Foundation, Danish National Research Foundation, Lundbeck Foundation, European Research Council, Research Council of Norway, Science Foundation Ireland, Gopalakrishnan, Shyam, Ebenesersdóttir, Sigríður Sunna, Lundstrøm, Inge K.C., Turner-Walker, Gordon, Moore, Kristjan H.S., Luisi, Pierre, Margaryan, Ashot, Martin, Michael D., Ellegaard, Martin Rene, Magnusson, Olafur þ., Sigurðsson, Ásgeir, Snorradóttir, Steinunn, Magnúsdóttir, Droplaug N., Laffoon, Jason, van Dorp, Lucy, Liu, Xiaodong, Moltke, Ida, Ávila-Arcos, María C., Schraiber, Joshua G., Rasmussen,Simon, Juan, David, Gelabert, Pere, De-Dios, Toni, Fotakis, Anna K., Iraeta-Orbegozo, Miren, Vågene, Åshild J., Dexter Denham, Sean, Christophersen, Axel, Stenøien, Hans K., Vieira, Filipe Garrett, Liu, Shanlin, Günther, Torsten, Kivisild, Toomas, Moseng, Ole Georg, Skar, Birgitte, Cheung, Christina, Sandoval-Velasco, Marcela, Wales, Nathan, Schroeder, Hannes, Campos, Paula F., Guðmundsdóttir, Valdís B., Sicheritz-Ponten, Thomas, Petersen, Bent, Halgunset, Jostein, Gilbert, Edmund, Cavalleri, Gianpiero L., Hovig, Eivind, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Hansen, Thomas F., Werge, Thomas, Willerslev, Eske, Balloux, François, Marqués-Bonet, Tomàs, Lalueza-Fox, Carles, Nielsen, Rasmus, Stefánsson, Kári, Helgason, Agnar, and Gilbert, M. Thomas P.
- Abstract
Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned for over 300 years, with typical village and town mortality estimated at 10%–40%.1 It is assumed that this high mortality affected the gene pools of these populations. First, local population crashes reduced genetic diversity. Second, a change in frequency is expected for sequence variants that may have affected survival or susceptibility to the etiologic agent (Yersinia pestis).2 Third, mass mortality might alter the local gene pools through its impact on subsequent migration patterns. We explored these factors using the Norwegian city of Trondheim as a model, by sequencing 54 genomes spanning three time periods: (1) prior to the plague striking Trondheim in 1,349 CE, (2) the 17th–19th century, and (3) the present. We find that the pandemic period shaped the gene pool by reducing long distance immigration, in particular from the British Isles, and inducing a bottleneck that reduced genetic diversity. Although we also observe an excess of large FST values at multiple loci in the genome, these are shaped by reference biases introduced by mapping our relatively low genome coverage degraded DNA to the reference genome. This implies that attempts to detect selection using ancient DNA (aDNA) datasets that vary by read length and depth of sequencing coverage may be particularly challenging until methods have been developed to account for the impact of differential reference bias on test statistics.
- Published
- 2022
14. Newfoundland and Labrador: A mosaic founder population of an Irish and British diaspora from 300 years ago
- Author
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Gilbert, Edmund, primary, Zurel, Heather, additional, MacMillan, Margaret E., additional, Demiriz, Sedat, additional, Mirhendi, Sadra, additional, Merrigan, Michael, additional, O’Reilly, Seamus, additional, Molloy, Anne M., additional, Brody, Lawrence C., additional, Bodmer, Walter, additional, Leach, Richard A., additional, Scott, Roderick E. M., additional, Mugford, Gerald, additional, Randhawa, Ranjit, additional, Stephens, J. Claiborne, additional, Symington, Alison L., additional, Cavalleri, Gianpiero L., additional, and Phillips, Michael S., additional
- Published
- 2022
- Full Text
- View/download PDF
15. The Irish DNA Atlas: providing a map of Irish genetics in and out of Ireland.
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Gilbert, Edmund
- Subjects
- *
GENETICS - Published
- 2023
16. Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts.
- Author
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Binks SNM, Elliott KS, Muñiz-Castrillo S, Gilbert E, Kawasaki de Araujo T, Harper AR, Brown AC, Chong AY, Band G, Peris Sempere V, Pinto AL, Costantino F, Rayner NW, Mentzer AJ, Delanty N, Rogemond V, Picard G, Handel AE, Melzer N, Titulaer MJ, Lee ST, Leypoldt F, Kuhlenbaeumer G, Honnorat J, Mignot E, Cavelleri GL, Knight JC, and Irani SR
- Abstract
Encephalitis with antibodies to leucine-rich glioma-inactivated 1 (LGI1-Ab-E) is a common form of autoimmune encephalitis, presenting with seizures and neuropsychiatric changes, predominantly in older males. More than 90% of patients carry the human leucocyte antigen (HLA) class II allele, HLA-DRB1*07:01. However, this is also present in 25% of healthy controls. Therefore, we hypothesised the presence of additional genetic predispositions. In this genome-wide association study and meta-analysis, we studied a discovery cohort of 131 French LGI1-Ab-E and a validation cohort of 126 American, British and Irish LGI1-Ab-E patients, ancestry-matched to 2613 and 2538 European controls, respectively. Outside the known major HLA signal, we found two single nucleotide polymorphisms (SNPs) at genome-wide significance (p < 5 x 10-8), implicating PTPRD, a protein tyrosine phosphatase, and LINC00670, a non-protein coding RNA gene. Meta-analysis defined four additional non-HLA loci, including the protein coding COBL gene. Polygenic risk scores with and without HLA variants proposed a contribution of non-HLA loci. In silico network analyses suggested LGI1 and PTPRD mediated interactions via the established receptors of LGI1, ADAM22 and ADAM23. Our results identify new genetic loci in LGI1-Ab-E. These findings present opportunities for mechanistic studies and offer potential markers of susceptibility, prognostics and therapeutic responses., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.)
- Published
- 2024
- Full Text
- View/download PDF
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