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Your search keyword '"Ge, Haobo"' showing total 9 results
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9 results on '"Ge, Haobo"'

1. Tripodal BODIPY‐Tagged and Functional Molecular Probes: Synthesis, Computational Investigations and Explorations by Multiphoton Fluorescence Lifetime Imaging Microscopy.

Author

Lledos, Marina, Calatayud, David G., Cortezon‐Tamarit, Fernando, Ge, Haobo, Pourzand, Charareh, Botchway, Stanley W., Sodupe, Mariona, Lledós, Agustí, Eggleston, Ian M., and Pascu, Sofia I.

Subjects
CONFOCAL microscopy, STAINS & staining (Microscopy), CELL imaging, FLUOROPHORES, MICROSCOPY
Abstract

A range of novel BODIPY derivatives with a tripodal aromatic core was synthesized and characterized spectroscopically. These new fluorophores showed promising features as probes for in vitro assays in live cells and offer strategic routes for further functionalization towards hybrid nanomaterials. Incorporation of biotin tags facilitated proof‐of‐concept access to targeted bioconjugates as molecular probes. Computational explorations using DFT and TD‐DFT calculations identified the most stable tripodal linker conformations and predicted their absorption and emission behavior. The uptake and speciation of these molecules in living prostate cancer cells was imaged by single‐ and two‐photon excitation techniques coupled with two‐photon fluorescence lifetime imaging (2P FLIM). [ABSTRACT FROM AUTHOR]

Published
2024
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3. Structural and Functional Diversity in Rigid Thiosemicarbazones with Extended Aromatic Frameworks: Microwave-Assisted Synthesis and Structural Investigations

Author

Cortezon-Tamarit, Fernando, primary, Song, Kexin, additional, Kuganathan, Navaratnarajah, additional, Arrowsmith, Rory L., additional, Mota Merelo de Aguiar, Sara Raquel, additional, Waghorn, Philip A., additional, Brookfield, Adam, additional, Shanmugam, Muralidharan, additional, Collison, David, additional, Ge, Haobo, additional, Kociok-Köhn, Gabriele, additional, Pourzand, Charareh, additional, Dilworth, Jonathan Robin, additional, and Pascu, Sofia Ioana, additional

Published
2023
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4. Fluorescent naphthalimide boronates as theranostics: structural investigations, confocal fluorescence and multiphoton fluorescence lifetime imaging microscopy in living cells

Author

Green, Megan J., primary, Ge, Haobo, additional, Flower, Stephen E., additional, Pourzand, Charareh, additional, Botchway, Stanley W., additional, Wang, Hui-Chen, additional, Kuganathan, Navaratnarajah, additional, Kociok-Köhn, Gabriele, additional, Li, Meng, additional, Xu, Suying, additional, James, Tony D., additional, and Pascu, Sofia I., additional

Published
2023
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8. Functional, Aromatic, and Fluorinated Monothiosemicarbazones: Investigations into Their Structures and Activity toward the Gallium-68 Incorporation by Microwave Irradiation

Author

Sarpaki, Sophia, primary, Cortezon-Tamarit, Fernando, additional, Exner, Rüdiger Maria, additional, Song, Kexin, additional, de Aguiar, Sara Raquel Mota Merelo, additional, Ge, Haobo, additional, Pourzand, Charareh, additional, Paisey, Stephen James, additional, Kociok-Köhn, Gabriele, additional, Dilworth, Jonathan Robin, additional, Carroll, Laurence, additional, and Pascu, Sofia Ioana, additional

Published
2022
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9. Tripodal BODIPY-Tagged and Functional Molecular Probes: Synthesis, Computational Investigations and Explorations by Multiphoton Fluorescence Lifetime Imaging Microscopy.

Author

Lledos M, Calatayud DG, Cortezon-Tamarit F, Ge H, Pourzand C, Botchway SW, Sodupe M, Lledós A, Eggleston IM, and Pascu SI

Subjects
Humans, Microscopy, Fluorescence, Multiphoton methods, Density Functional Theory, Molecular Probes chemistry, Molecular Probes chemical synthesis, Cell Line, Tumor, Biotin chemistry, Boron Compounds chemistry, Fluorescent Dyes chemistry
Abstract

A range of novel BODIPY derivatives with a tripodal aromatic core was synthesized and characterized spectroscopically. These new fluorophores showed promising features as probes for in vitro assays in live cells and offer strategic routes for further functionalization towards hybrid nanomaterials. Incorporation of biotin tags facilitated proof-of-concept access to targeted bioconjugates as molecular probes. Computational explorations using DFT and TD-DFT calculations identified the most stable tripodal linker conformations and predicted their absorption and emission behavior. The uptake and speciation of these molecules in living prostate cancer cells was imaged by single- and two-photon excitation techniques coupled with two-photon fluorescence lifetime imaging (2P FLIM)., (© 2024 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)

Published
2024
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