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41 results on '"Gallimore, Awen"'

1. Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort)

Author

Hopkins, Georgina, Gomez, Nancy, Tucis, Davis, Bartlett, Laura, Steers, Graham, Burns, Ellie, Brown, Michaela, Harvey-Cowlishaw, Tyler, Santos, Rute, Lauder, Sarah N, Scurr, Martin, Capitani, Lorenzo, Burnell, Stephanie, Rees, Tara, Smart, Kathryn, Somerville, Michelle, Gallimore, Awen, Perera, Marianne, Potts, Martin, Metaxaki, Marina, Krishna, Benjamin, Jackson, Hannah, Tighe, Paddy, Onion, David, Godkin, Andrew, Wills, Mark, and Fairclough, Lucy

Published
2024
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3. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation

Author

Hulin-Curtis, Sarah, Geary, James K., MacLachlan, Bruce J., Altmann, Danny M., Baillon, Laury, Cole, David K., Greenshields-Watson, Alex, Hesketh, Sophie J., Humphreys, Ian R., Jones, Ian M., Lauder, Sarah N., Mason, Georgina H., Smart, Kathryn, Scourfield, D. Oliver, Scott, Jake, Sukhova, Ksenia, Stanton, Richard J., Wall, Aaron, Rizkallah, Pierre J., Barclay, Wendy S., Gallimore, Awen, and Godkin, Andrew

Published
2024
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8. Lower Humoral and Cellular Immunity following Asymptomatic SARS-CoV-2 Infection in Education (The ACE Cohort)

Author

Hopkins, Georgina, primary, Gomez, Nancy, additional, Tucis, Davis, additional, Bartlett, Laura, additional, Steers, Graham, additional, Burns, Ellie, additional, Brown, Michaela, additional, Harvey-Cowlishaw, Tyler, additional, Santos, Rute, additional, Lauder, Sarah N, additional, Scurr, Martin, additional, Capitani, Lorenzo, additional, Burnell, Stephanie, additional, Rees, Tara, additional, Smart, Kathryn, additional, Somerville, Michelle, additional, Gallimore, Awen, additional, Perera, Marianne, additional, Potts, Martin, additional, Metaxaki, Marina, additional, Krishna, Benjamin, additional, Jackson, Hannah, additional, Tighe, Paddy, additional, Onion, David, additional, Godkin, Andrew, additional, Wills, Mark, additional, and Fairclough, Lucy, additional

Published
2024
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10. TIM3 is a context-dependent co-regulator of cytotoxic T cell function

Author

Alamir, Hanin, primary, Wong, Carissa C.W., additional, Alsubaiti, Amal, additional, Edmunds, Grace L., additional, Grant, Tressan, additional, Alsulaimani, Safaa, additional, Boyd, James, additional, Holland, Christopher J., additional, Morgan, David J., additional, Gallimore, Awen M., additional, and Wülfing, Christoph, additional

Published
2023
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11. Figure S5 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, primary, Jones, Emma, primary, Kelch, Inken, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Ware, Carl, primary, Godkin, Andrew, primary, Stein, Jens V., primary, Bogle, Gib, primary, and Gallimore, Awen, primary

Published
2023
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12. Supplementary Figures from Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection

Author

Pires, Ana, primary, Greenshields-Watson, Alexander, primary, Jones, Emma, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Milutinovic, Stefan, primary, Kendrick, Howard, primary, Hindley, James P., primary, French, Rhiannon, primary, Smalley, Matthew J., primary, Watkins, William J., primary, Andrews, Robert, primary, Godkin, Andrew, primary, and Gallimore, Awen, primary

Published
2023
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13. Data from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, primary, Jones, Emma, primary, Kelch, Inken, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Ware, Carl, primary, Godkin, Andrew, primary, Stein, Jens V., primary, Bogle, Gib, primary, and Gallimore, Awen, primary

Published
2023
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14. Supplementary Movie 2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, primary, Jones, Emma, primary, Kelch, Inken, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Ware, Carl, primary, Godkin, Andrew, primary, Stein, Jens V., primary, Bogle, Gib, primary, and Gallimore, Awen, primary

Published
2023
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15. Supplementary Movie 1 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, primary, Jones, Emma, primary, Kelch, Inken, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Ware, Carl, primary, Godkin, Andrew, primary, Stein, Jens V., primary, Bogle, Gib, primary, and Gallimore, Awen, primary

Published
2023
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16. Data from Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection

Author

Pires, Ana, primary, Greenshields-Watson, Alexander, primary, Jones, Emma, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Milutinovic, Stefan, primary, Kendrick, Howard, primary, Hindley, James P., primary, French, Rhiannon, primary, Smalley, Matthew J., primary, Watkins, William J., primary, Andrews, Robert, primary, Godkin, Andrew, primary, and Gallimore, Awen, primary

Published
2023
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17. Supplementary Movie 3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, primary, Jones, Emma, primary, Kelch, Inken, primary, Smart, Kathryn, primary, Lauder, Sarah N., primary, Somerville, Michelle, primary, Ware, Carl, primary, Godkin, Andrew, primary, Stein, Jens V., primary, Bogle, Gib, primary, and Gallimore, Awen, primary

Published
2023
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19. Data from Escalating Regulation of 5T4-Specific IFN-γ+ CD4+ T Cells Distinguishes Colorectal Cancer Patients from Healthy Controls and Provides a Target for In Vivo Therapy

Author

Scurr, Martin, primary, Bloom, Anja, primary, Pembroke, Tom, primary, Srinivasan, Rohit, primary, Brown, Clare, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Davies, Mike, primary, Hargest, Rachel, primary, Phillips, Simon, primary, Christian, Adam, primary, Hockey, Tom, primary, Gallimore, Awen, primary, and Godkin, Andrew, primary

Published
2023
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21. Supplementary Figure Legend from Escalating Regulation of 5T4-Specific IFN-γ+ CD4+ T Cells Distinguishes Colorectal Cancer Patients from Healthy Controls and Provides a Target for In Vivo Therapy

Author

Scurr, Martin, primary, Bloom, Anja, primary, Pembroke, Tom, primary, Srinivasan, Rohit, primary, Brown, Clare, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Davies, Mike, primary, Hargest, Rachel, primary, Phillips, Simon, primary, Christian, Adam, primary, Hockey, Tom, primary, Gallimore, Awen, primary, and Godkin, Andrew, primary

Published
2023
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23. Supplementary Figures 1 - 4 from Escalating Regulation of 5T4-Specific IFN-γ+ CD4+ T Cells Distinguishes Colorectal Cancer Patients from Healthy Controls and Provides a Target for In Vivo Therapy

Author

Scurr, Martin, primary, Bloom, Anja, primary, Pembroke, Tom, primary, Srinivasan, Rohit, primary, Brown, Clare, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Davies, Mike, primary, Hargest, Rachel, primary, Phillips, Simon, primary, Christian, Adam, primary, Hockey, Tom, primary, Gallimore, Awen, primary, and Godkin, Andrew, primary

Published
2023
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24. Supplementary Data from Low-Dose Cyclophosphamide Induces Antitumor T-Cell Responses, which Associate with Survival in Metastatic Colorectal Cancer

Author

Scurr, Martin, primary, Pembroke, Tom, primary, Bloom, Anja, primary, Roberts, David, primary, Thomson, Amanda, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Adams, Richard, primary, Brewster, Alison, primary, Jones, Robert, primary, Gwynne, Sarah, primary, Blount, Daniel, primary, Harrop, Richard, primary, Hills, Robert, primary, Gallimore, Awen, primary, and Godkin, Andrew, primary

Published
2023
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25. Supplementary Tables from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells

Author

Scurr, Martin J., primary, Greenshields-Watson, Alex, primary, Campbell, Emma, primary, Somerville, Michelle S., primary, Chen, Yuan, primary, Hulin-Curtis, Sarah L., primary, Burnell, Stephanie E.A., primary, Davies, James A., primary, Davies, Michael M., primary, Hargest, Rachel, primary, Phillips, Simon, primary, Christian, Adam D., primary, Ashelford, Kevin E., primary, Andrews, Robert, primary, Parker, Alan L., primary, Stanton, Richard J., primary, Gallimore, Awen, primary, and Godkin, Andrew, primary

Published
2023
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26. Data from T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion

Author

Hindley, James P., primary, Jones, Emma, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Lauder, Sarah N., primary, Ondondo, Beatrice, primary, Cutting, Scott, primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Withers, David, primary, Price, David A., primary, Ager, Ann, primary, Godkin, Andrew J., primary, and Gallimore, Awen M., primary

Published
2023
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27. Supplementary Figures 1-3 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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28. Data from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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29. Supplementary Figure 6 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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30. Supplementary Figure 4 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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31. Supplementary Figure Legends 1-7 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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32. Supplementary Figure 5 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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33. Supplementary Figure 7 from Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

Author

Hindley, James P., primary, Ferreira, Cristina, primary, Jones, Emma, primary, Lauder, Sarah N., primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Betts, Gareth J., primary, Singh, Yogesh, primary, Price, David A., primary, Godkin, Andrew J., primary, Dyson, Julian, primary, and Gallimore, Awen, primary

Published
2023
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34. Supplementary Figures 1-6 from T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion

Author

Hindley, James P., primary, Jones, Emma, primary, Smart, Kathryn, primary, Bridgeman, Hayley, primary, Lauder, Sarah N., primary, Ondondo, Beatrice, primary, Cutting, Scott, primary, Ladell, Kristin, primary, Wynn, Katherine K., primary, Withers, David, primary, Price, David A., primary, Ager, Ann, primary, Godkin, Andrew J., primary, and Gallimore, Awen M., primary

Published
2023
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35. A Targeted Amino Acid Mutation in Influenza a Virus Universal Epitope Transforms Immunogenicity and Protective Immunity via CD4 T Cell Activation

Author

Hulin-Curtis, Sarah Louise, primary, Geary, James, additional, MacLachlan, Bruce, additional, Altmann, Daniel, additional, Baillon, Laury, additional, Cole, David, additional, Greenshields-Watson, Alexander, additional, Hesketh, Sophie, additional, Humphreys, Ian R., additional, Jones, Ian, additional, Lauder, Sarah, additional, Mason, Georgina, additional, Smart, Kathryn, additional, Scourfield, Oliver, additional, Scott, Jake, additional, Sukhova, Ksenia, additional, Stanton, Richard J., additional, Wall, Aaron, additional, Rizkallah, Pierre, additional, Barclay, Wendy S., additional, Gallimore, Awen, additional, and Godkin, Andrew, additional

Published
2023
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37. Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Author

Milutinovic, Stefan, primary, Abe, Jun, additional, Jones, Emma, additional, Kelch, Inken, additional, Smart, Kathryn, additional, Lauder, Sarah N., additional, Somerville, Michelle, additional, Ware, Carl, additional, Godkin, Andrew, additional, Stein, Jens V., additional, Bogle, Gib, additional, and Gallimore, Awen, additional

Published
2022
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39. Whole blood‐based measurement of SARS‐CoV‐2‐specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid‐organ cancers.

Author

Scurr, Martin J., Zelek, Wioleta M., Lippiatt, George, Somerville, Michelle, Burnell, Stephanie E. A., Capitani, Lorenzo, Davies, Kate, Lawton, Helen, Tozer, Thomas, Rees, Tara, Roberts, Kerry, Evans, Mererid, Jackson, Amanda, Young, Charlotte, Fairclough, Lucy, Tighe, Paddy, Wills, Mark, Westwell, Andrew D., Morgan, B. Paul, and Gallimore, Awen

Subjects
T cells, IMMUNE response, BLOOD plasma, BOOSTER vaccines, CANCER patients
Abstract

Accurate assessment of SARS‐CoV‐2 immunity is critical in evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS‐CoV‐2‐specific T‐cell responses are a critical feature that will likely form a key correlate of protection against COVID‐19. Here, we developed and optimized a high‐throughput whole blood‐based assay to determine the T‐cell response associated with prior SARS‐CoV‐2 infection and/or vaccination amongst 231 healthy donors and 68 cancer patients. Following overnight in vitro stimulation with SARS‐CoV‐2‐specific peptides, blood plasma samples were analysed for TH1‐type cytokines. Highly significant differential IFN‐γ+/IL‐2+ SARS‐CoV‐2‐specific T‐cell responses were seen amongst previously infected COVID‐19‐positive healthy donors in comparison with unknown / naïve individuals (p < 0·0001). IFN‐γ production was more effective at identifying asymptomatic donors, demonstrating higher sensitivity (96·0% vs. 83·3%) but lower specificity (84·4% vs. 92·5%) than measurement of IL‐2. A single COVID‐19 vaccine dose induced IFN‐γ and/or IL‐2 SARS‐CoV‐2‐specific T‐cell responses in 116 of 128 (90·6%) healthy donors, reducing significantly to 27 of 56 (48·2%) when measured in cancer patients (p < 0·0001). A second dose was sufficient to boost T‐cell responses in the majority (90·6%) of cancer patients, albeit IFN‐γ+ responses were still significantly lower overall than those induced in healthy donors (p = 0·034). Three‐month post‐vaccination T‐cell responses also declined at a faster rate in cancer patients. Overall, this cost‐effective standardizable test ensures accurate and comparable assessments of SARS‐CoV‐2‐specific T‐cell responses amenable to widespread population immunity testing, and identifies individuals at greater need of booster vaccinations. [ABSTRACT FROM AUTHOR]

Published
2022
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40. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+T cell activation

Author

Hulin-Curtis, Sarah, Geary, James K., MacLachlan, Bruce J., Altmann, Danny M., Baillon, Laury, Cole, David K., Greenshields-Watson, Alex, Hesketh, Sophie J., Humphreys, Ian R., Jones, Ian M., Lauder, Sarah N., Mason, Georgina H., Smart, Kathryn, Scourfield, D. Oliver, Scott, Jake, Sukhova, Ksenia, Stanton, Richard J., Wall, Aaron, Rizkallah, Pierre J., Barclay, Wendy S., Gallimore, Awen, and Godkin, Andrew

Abstract

CD4+T cells are central to adaptive immunity. Their role in cross-protection in viral infections such as influenza and severe acute respiratory syndrome (SARS) is well documented; however, molecular rules governing T cell receptor (TCR) engagement of peptide-human leukocyte antigen (pHLA) class II are less understood. Here, we exploit an aspect of HLA class II presentation, the peptide-flanking residues (PFRs), to “tune” CD4+T cell responses within an in vivomodel system of influenza. Using a recombinant virus containing targeted substitutions at immunodominant HLA-DR1 epitopes, we demonstrate limited weight loss and improved clinical scores after heterosubtypic re-challenge. We observe enhanced protection linked to lung-derived influenza-specific CD4+and CD8+T cells prior to re-infection. Structural analysis of the ternary TCR:pHLA complex identifies that flanking amino acids influence side chains in the core 9-mer peptide, increasing TCR affinity. Augmentation of CD4+T cell immunity is achievable with a single mutation, representing a strategy to enhance adaptive immunity that is decoupled from vaccine modality.

Published
2024
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41. Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+T cell immunity

Author

Chen, Yuan, Mason, Georgina H., Scourfield, D. Oliver, Greenshields-Watson, Alexander, Haigh, Tracey A., Sewell, Andrew K., Long, Heather M., Gallimore, Awen M., Rizkallah, Pierre, MacLachlan, Bruce J., and Godkin, Andrew

Abstract

CD4+T cells recognize a broad range of peptide epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which contribute to immune memory and limit COVID-19 disease. We demonstrate that the immunogenicity of SARS-CoV-2 peptides, in the context of the model allotype HLA-DR1, does not correlate with their binding affinity to the HLA heterodimer. Analyzing six epitopes, some with very low binding affinity, we solve X-ray crystallographic structures of each bound to HLA-DR1. Further structural definitions reveal the precise molecular impact of viral variant mutations on epitope presentation. Omicron escaped ancestral SARS-CoV-2 immunity to two epitopes through two distinct mechanisms: (1) mutations to TCR-facing epitope positions and (2) a mechanism whereby a single amino acid substitution caused a register shift within the HLA binding groove, completely altering the peptide-HLA structure. This HLA-II-specific paradigm of immune escape highlights how CD4+T cell memory is finely poised at the level of peptide-HLA-II presentation.

Published
2023
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