15 results on '"Frederic Dubois"'
Search Results
2. Electrical resistivity-based approach to characterize moisture content in compressed earth bricks
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Tuan Anh Nguyen, Minh Dung Pham, Wael Hafsa, Nicolas Angellier, Laurent Ulmet, and Frédéric Dubois
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Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Compressed earth bricks (CEBs) are increasingly used as a sustainable building material, but their hygroscopic nature makes them susceptible to moisture-related degradation. Monitoring moisture content in CEBs is crucial for ensuring structural integrity and durability, yet existing methods are often destructive or limited in application. This study presents a non-destructive approach for assessing moisture content in CEBs using electrical resistivity measurements, adapted from geophysical surveying techniques. The research employed a modified Syscal Junior Switch-48 resistivity meter with 4-electrode and 16-electrode configurations to measure electrical resistance in CEB samples under controlled relative humidity conditions ranging from 20 % to 100 %. Clear logarithmic correlations were established between moisture content (1.86–9.48 %) and electrical resistivity. The measured electrical resistivity varied from 12.4Ωm at 9.48 % moisture content to 3350Ωm at 1.86 % moisture content, demonstrating the method's sensitivity across a wide range of moisture levels. The 50 mA measurement mode demonstrated capability to assess moisture levels down to 1.86 %, while the standard 1250 mA mode was effective above 2.9 % moisture content. Numerical modeling using finite element analysis was conducted to determine geometric factors and true resistivity values. The 16-electrode multiplexed measurements showed good agreement with the experimental trend, enabling potential internal moisture mapping. This application of resistivity measurements represents a significant advance in non-destructive monitoring of earthen construction materials.
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- 2024
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3. Structural, thermal, optical and dielectric properties of piezoelectric Ba0.8Ca0.2TiO3/polyvinyl alcohol nanocomposite films
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Mohamed Hassen Khedhri, Mohamed Lajnef, Slim Salhi, Najmeddine Abdelmoula, Hamadi Khemakhem, Frederic Dubois, and Redouane Douali
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General Materials Science ,General Chemistry - Published
- 2022
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4. Assessment of a Moisture Content Profile in Douglas-Fir Wood Using Electrical Resistivity-Based Method
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Hafsa, Wael, primary, Nguyen, Tuan Anh, additional, Angellier, Nicolas, additional, Ulmet, Laurent, additional, Takarli, mokhfi, additional, Pop, Octavian, additional, and Frederic, Dubois, additional
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- 2022
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5. A New Three Dimensional Model for the Prediction of Ultrasonic Velocity in Orthotropic Wood Materials
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Frederic, Dubois, primary, Afoutou, Jerome, additional, Sauvat, Nicolas, additional, and Takarli, mokhfi, additional
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- 2022
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6. Randomized phase 2 study evaluating efficacy and safety of inupadenant in combination with chemotherapy in adults with metastatic non–small cell lung cancer (mNSCLC) who progressed on immunotherapy
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Mary E.R. O'Brien, Parneet K. Cheema, Christian Grohé, Enric Carcereny Costa, Nicolas Girard, Alberto Chiappori, Sally Ross, Maura Rossetti, Frederic Dubois, Joanne J. Lager, Shouryadeep Srivastava, and Vamsidhar Velcheti
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Cancer Research ,Oncology - Abstract
TPS9158 Background: In cancer, the accumulation of adenosine in the tumor microenvironment (TME) mediates immune suppression mainly via the high affinity A2A receptor (A2AR), causing dysregulation of innate and adaptative immune cell subsets and dampening the antitumor immune response. This results in increased tumor cell survival and immune escape (Blay 1997; Merighi 2003; Muller-Haegele 2014). Therefore, inhibiting A2AR could reverse immunosuppression and re-establish immune surveillance in the tumor microenvironment. Inupadenant is an antagonist of the A2AR with potent inhibition of A2AR even at the high concentrations of adenosine present in the tumor microenvironment. Ongoing clinical studies have established inupadenant as a molecule with a favorable safety profile with preliminary evidence of clinical activity in multiple tumor types, including durable PRs in patients who have exhausted standard treatment options (Buisseret 2021). The standard treatment for patients without a driving mutation who progress on first-line IO is a platinum-based doublet chemotherapy regimen. Carboplatin plus Pemetrexed (C+P) is the preferred chemotherapy in nonsquamous mNSCLC. Study A2A-005 will evaluate the efficacy of inupadenant in combination with C+P as a second-line therapy in adult patients with nonsquamous mNSCLC (post-IO). A successful outcome from study A2A-005 will help address a high unmet need for this patient population and could lead to new therapeutic options. Methods: This is a 2-part study. The first part is an open label dose-finding part to determine the safety and recommended Phase 2 dose (RP2D) of inupadenant in combination with C+P (N = 40). In Part 2, 150 patients will be randomized 1:1 to inupadenant or placebo, both in combination with C+P. Tumor response will be determined according to RECIST 1.1 criteria and safety findings will be reviewed by the Safety Review Committee (for Part 1) and the Data Monitoring Committee (for Part 2). Key eligibility criteria include 1) mNSCLC of nonsquamous pathology, 2) have received only 1 line of anti-PD-(L)1 therapy in the metastatic setting, without concomitant chemotherapy, and have progressed (IO/IO combination therapy is allowed), 3) have measurable disease as defined by RECIST v1.1 criteria and 4) Eastern Cooperative Oncology Group status ≤1. Primary endpoints are RP2D (for Part 1) and PFS (for Part 2). Secondary endpoints include change in tumor size, ORR, OS, and adverse events. Correlative aims include assessing blood and tissue biomarkers for association with clinical benefit. The study will be conducted in approximately 11 countries in North America and Europe. Clinical trial information: EudraCT 2021-005487-22.
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- 2022
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7. Integrating Wind Flow Analysis in Early Urban Design: Guidelines for Practitioners
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Mathieu Paris, Frédéric Dubois, Stéphane Bosc, and Philippe Devillers
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architectural and environmental sustainability ,urban morphology ,urban design ,wind flow ,outdoor thermal comfort ,mediterranean climate ,Urban renewal. Urban redevelopment ,HT170-178 - Abstract
The research focused on simulating wind patterns in urban planning design offers substantial contributions to both the social and economic aspects of the urban planning and design field. To begin with, it addresses a critical factor in urban development, especially in Mediterranean climates, where natural ventilation significantly influences summer comfort. By incorporating predictive numerical simulations of urban wind patterns, this study provides valuable insights into improving outdoor thermal comfort within urban areas. This holds particular importance in the context of adapting to climate change, as it equips urban planners and architects with informed decision-making tools to create more sustainable and comfortable urban environments. Additionally, this research makes an economic contribution by presenting guidelines for iterative wind simulations in the early stages of designing medium-scale urban projects. Through the validation of a simulation workflow, it streamlines the design process, potentially reducing the time and resources required for urban planning and architectural design. This enhanced efficiency can result in cost savings during project development. Moreover, the study's recommendations concerning simulation parameters, such as wind tunnel cell size and refinement levels, offer practical insights for optimizing simulation processes, potentially lowering computational expenses and improving the overall economic viability of urban design projects. To summarize, this research effectively addresses climate-related challenges, benefiting both social well-being and economic efficiency in the field of urban planning and design, while also providing guidance for more efficient simulation-driven design procedures.
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- 2023
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8. Estimation of Ionic Impurities in Poly(propylene Glycol) Diacrylate Monomers/Liquid Crystal E7 Mixtures Using Dielectric Spectroscopy
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Tayeb Benkouider, Yazid Derouiche, Lahcene Souli, Frédéric Dubois, Ana Barrera, Zohra Bouberka, and Ulrich Maschke
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poly(propylene glycol) diacrylate ,liquid crystal ,dielectric spectroscopy ,ionic conductivity ,Crystallography ,QD901-999 - Abstract
The study investigated the effect of the molecular weight of three difunctional poly(propylene glycol) diacrylates on the temperature-dependent ionic conductivity of these monomers and their blends with an eutectic nematic liquid crystal mixture (E7). The results revealed two distinct regions. At low temperatures, ionic conduction can be described by the Vogel–Tamman–Fulcher (VTF) equation, while at high temperatures, the conductivity data follow the prediction of the Arrhenius model. The Arrhenius and VTF parameters and their corresponding activation energies were determined using the least squares method. In addition, a conductivity analysis based on an ionic hopping model is proposed. Estimates of ion concentrations and diffusion constants were calculated. It was found that both the ionic concentration and the diffusion constant decrease with the increase in the molecular weight of the monomers. The static dielectric permittivity decreases in the following order: TPGDA, PPGDA540, and PPGDA900. This can be explained by the higher dipole moment of TPGDA, which is caused by an enhanced volume density of carbonyl groups.
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- 2024
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9. PGPR-Soil Microbial Communities’ Interactions and Their Influence on Wheat Growth Promotion and Resistance Induction against Mycosphaerella graminicola
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Erika Samain, Jérôme Duclercq, Essaïd Ait Barka, Michael Eickermann, Cédric Ernenwein, Candice Mazoyon, Vivien Sarazin, Frédéric Dubois, Thierry Aussenac, and Sameh Selim
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Mycosphaerella graminicola ,Paenibacillus sp. strain B2 ,Arthrobacter spp. ,Microbacterium spp. ,PGPR co-inoculation ,induced systemic resistance ,Biology (General) ,QH301-705.5 - Abstract
The efficiency of plant-growth-promoting rhizobacteria (PGPR) may not be consistently maintained under field conditions due to the influence of soil microbial communities. The present study aims to investigate their impact on three PGPR-based biofertilizers in wheat. We used the PGPR Paenibacillus sp. strain B2 (PB2), PB2 in co-inoculation with Arthrobacter agilis 4042 (Mix 2), or with Arthrobacter sp. SSM-004 and Microbacterium sp. SSM-001 (Mix 3). Inoculation of PB2, Mix 2, and Mix 3 into non-sterile field soil had a positive effect on root and aboveground dry biomass, depending on the wheat cultivar. The efficiency of the PGPR was further confirmed by the protection they provided against Mycosphaerella graminicola, the causal agent of Septoria leaf blotch disease. PB2 exhibited protection of ≥37.8%, while Mix 2 showed ≥47.9% protection in the four cultivars tested. These results suggest that the interactions between PGPR and native soil microbial communities are crucial for promoting wheat growth and protection. Additionally, high-throughput sequencing of microbial communities conducted 7 days after PGPR inoculations revealed no negative effects of PB2, Mix 2, and Mix 3 on the soil microbial community structure. Interestingly, the presence of Arthrobacter spp. appeared to mitigate the potential negative effect of PB2 on bacterial community and foster root colonization by other beneficial bacterial strains.
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- 2023
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10. Sphingomonas sediminicola Dae20 Is a Highly Promising Beneficial Bacteria for Crop Biostimulation Due to Its Positive Effects on Plant Growth and Development
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Candice Mazoyon, Manuella Catterou, Abdelrahman Alahmad, Gaëlle Mongelard, Stéphanie Guénin, Vivien Sarazin, Fréderic Dubois, and Jérôme Duclercq
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plant growth-promoting bacteria (PGPR) ,Sphingomonas sediminicola Dae20 ,root stimulation ,growth promotion ,Brassicaceae plants ,sustainable agriculture ,Biology (General) ,QH301-705.5 - Abstract
Current agricultural practices rely heavily on synthetic fertilizers, which not only consume a lot of energy but also disrupt the ecological balance. The overuse of synthetic fertilizers has led to soil degradation. In a more sustainable approach, alternative methods based on biological interactions, such as plant growth-promoting bacteria (PGPRs), are being explored. PGPRs, which include both symbiotic and free-living bacteria, form mutualistic relationships with plants by enhancing nutrient availability, producing growth regulators, and regulating stress responses. This study investigated the potential of Sphingomonas sediminicola Dae20, an α-Proteobacteria species commonly found in the rhizosphere, as a beneficial PGPR. We observed that S. sediminicola Dae20 stimulated the root system and growth of three different plant species in the Brassicaceae family, including Arabidopsis thaliana, mustard, and rapeseed. The bacterium produced auxin, nitric oxide, siderophores and showed ACC deaminase activity. In addition to activating an auxin response in the plant, S. sediminicola Dae20 exhibited the ability to modulate other plant hormones, such as abscisic acid, jasmonic acid and salicylic acid, which are critical for plant development and defense responses. This study highlights the multifunctional properties of S. sediminicola Dae20 as a promising PGPR and underscores the importance of identifying effective and versatile beneficial bacteria to improve plant nutrition and promote sustainable agricultural practices.
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- 2023
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11. Optimizing Crop Production with Bacterial Inputs: Insights into Chemical Dialogue between Sphingomonas sediminicola and Pisum sativum
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Candice Mazoyon, Stéphane Firmin, Lamine Bensaddek, Audrey Pecourt, Amélie Chabot, Michel-Pierre Faucon, Vivien Sarazin, Fréderic Dubois, and Jérôme Duclercq
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Sphingomonas sediminicola ,pea ,root exudates ,plant–bacteria interaction ,molecular dialogue plant–bacteria ,Biology (General) ,QH301-705.5 - Abstract
The use of biological inputs is an interesting approach to optimize crop production and reduce the use of chemical inputs. Understanding the chemical communication between bacteria and plants is critical to optimizing this approach. Recently, we have shown that Sphingomonas (S.) sediminicola can improve both nitrogen supply and yield in pea. Here, we used biochemical methods and untargeted metabolomics to investigate the chemical dialog between S. sediminicola and pea. We also evaluated the metabolic capacities of S. sediminicola by metabolic profiling. Our results showed that peas release a wide range of hexoses, organic acids, and amino acids during their development, which can generally recruit and select fast-growing organisms. In the presence of S. sediminicola, a more specific pattern of these molecules took place, gradually adapting to the metabolic capabilities of the bacterium, especially for pentoses and flavonoids. In turn, S. sediminicola is able to produce several compounds involved in cell differentiation, biofilm formation, and quorum sensing to shape its environment, as well as several molecules that stimulate pea growth and plant defense mechanisms.
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- 2023
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12. Chemical Characterization and Thermal Analysis of Recovered Liquid Crystals
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Ana Barrera, Corinne Binet, Florence Danede, Jean-François Tahon, Baghdad Ouddane, Frédéric Dubois, Philippe Supiot, Corinne Foissac, and Ulrich Maschke
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End-Of-Life Liquid Crystal Displays ,nematic liquid crystals ,recycling ,chemical and thermal properties ,Crystallography ,QD901-999 - Abstract
Chemical, structural, and thermal properties of recovered nematic Liquid Crystal (LC) mixtures were investigated by applying several analytical techniques. A large quantity (65,700) of End-Of-Life (EOL) Liquid Crystal Display (LCD) screens were used to extract these LC blends. The studied EOL-LCD screens were heterogeneous in nature, particularly due to their different brands, production years, and dimensions. The collected TV and computer screens, as well as tablets, presented an average diagonal size of 24 inches. Chemical characterization revealed that the recovered compounds present typical chemical structures of LC molecules by the simultaneous presence of aliphatic chains and aromatic and polar groups. POM observations of these samples exhibited Schlieren and marble-like textures at room temperature, which are typical of nematic LCs. Moreover, thermal characterization and thermo-optical analysis showed that these LC mixtures displayed a broad nematic phase between −90 °C and +70 °C.
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- 2023
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13. Splitting Nitrogen Fertilization Is More Important than Nitrogen Level When Mixed Wheat Varieties Are Cultivated in a Conservation Agriculture System
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Kévin Allart, Ali Almoussawi, Louay Kerbey, Manuella Catterou, David Roger, David Mortier, Elisa Blanc, Bastien Robert, Fabien Spicher, Léa Emery, Bertrand Hirel, Frédéric Dubois, and Thierry Tetu
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soil conservation agriculture ,15N recovery ,cover crops ,nitrogen fertilization ,nitrogen use efficiency ,winter wheat ,Agriculture - Abstract
Nitrogen (N) is one of the most limiting nutrients for cereal production, especially in wheat, which is one of the main crops cultivated globally. To achieve high yields, wheat requires a certain amount of nitrogen (N), as N deficiency can lead to a decrease in yield and thus reduce income for farmers. In contrast, excessive applications of N fertilizer can be detrimental to both terrestrial and aquatic environments. To optimize N fertilizer applications in wheat, a three-year field experiment was conducted to evaluate the impact of different N fertilization strategies on various N-related physiological and agronomic traits. Moreover, to optimize N utilization efficiency while maintaining crop productivity, a mixture of five winter wheat varieties was used to mitigate the possible impact of environmental constraints. These strategies were based on a simultaneous increase in N fertilization and N fertilizer fractionation at key stages of plant development in a soil conservation agriculture (SCA) system in which legumes were grown prior to the cultivation of the main crop. In this SCA system, we observed that 200 kgN·ha−1 was optimal for both N use efficiency (NUE) and aerial and grain biomass production. Moreover, we found that at this level of N fertilization, of the application strategies, a 40%/40%/20% split application at full tillering, at the first node, and at booting, respectively, appeared to be the best option for the highest plant productivity.
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- 2023
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14. Sphingomonas sediminicola Is an Endosymbiotic Bacterium Able to Induce the Formation of Root Nodules in Pea (Pisum sativum L.) and to Enhance Plant Biomass Production
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Candice Mazoyon, Bertrand Hirel, Audrey Pecourt, Manuella Catterou, Laurent Gutierrez, Vivien Sarazin, Fréderic Dubois, and Jérôme Duclercq
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Sphingomonas sediminicola ,Pisum sativum ,PGRP ,rhizobacteria ,nodulation ,Biology (General) ,QH301-705.5 - Abstract
The application of bacterial bio-inputs is a very attractive alternative to the use of mineral fertilisers. In ploughed soils including a crop rotation pea, we observed an enrichment of bacterial communities with Sphingomonas (S.) sediminicola. Inoculation experiments, cytological studies, and de novo sequencing were used to investigate the beneficial role of S. sediminicola in pea. S. sediminicola is able to colonise pea plants and establish a symbiotic association that promotes plant biomass production. Sequencing of the S. sediminicola genome revealed the existence of genes involved in secretion systems, Nod factor synthesis, and nitrogenase activity. Light and electron microscopic observations allowed us to refine the different steps involved in the establishment of the symbiotic association, including the formation of infection threads, the entry of the bacteria into the root cells, and the development of differentiated bacteroids in root nodules. These results, together with phylogenetic analysis, demonstrated that S. sediminicola is a non-rhizobia that has the potential to develop a beneficial symbiotic association with a legume. Such a symbiotic association could be a promising alternative for the development of more sustainable agricultural practices, especially under reduced N fertilisation conditions.
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- 2023
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15. End-of-Life Liquid Crystal Displays Recycling: Physico-Chemical Properties of Recovered Liquid Crystals
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Idriss Moundoungou, Zohra Bouberka, Guy-Joël Fossi Tabieguia, Ana Barrera, Yazid Derouiche, Frédéric Dubois, Philippe Supiot, Corinne Foissac, and Ulrich Maschke
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WEEE ,liquid crystal displays ,liquid crystals ,recycling ,Crystallography ,QD901-999 - Abstract
This report focuses particularly on liquid crystals display (LCD) panels because they represent a significant amount of all WEEE collected. Technologies involving liquid crystals (LCs) have enjoyed considerable success since the 1970s in all fields of LC displays (LCDs). This currently provokes the problem of waste generated by such equipment. Based on current statistical data, the LC amount represents approximately 1.3 g for a 35-inch diameter LCD panel unit possessing a total weight of 15 kg. In France, a recent study revealed LCD waste to represent an average of 5.6 panels per household. This represents an important quantity of LCs, which are generally destroyed by incineration or washed out with detergents during the recycling processes of end-of-life (EOL) LCDs. Hence, the aim of this study is to show that it is possible to remove LC molecules from EOL-LCD panels with the goal of valorizing them in new sectors. EOL-LCD panels have undergone various stages of dismantling, chemical treatments and characterization. The first stage of manual dismantling enables the elimination of the remaining physical components of the panels to process LC molecules only, sandwiched between the two glass plates. Mechanical treatment by scraping allows us to obtain a concentrate of LCs. The results obtained from chemical and physical techniques show that these molecules retain the characteristics essential for their operation in the field of optical and electro-optical devices. As the use of LCD surfaces continues to rise significantly, the amounts and economic stakes are huge, fully justifying the development of an LC recovery process for used panels. Many potential uses have been identified for these LC molecules: in new flat LCD panels after purification of the LCs concentrate, in PDLC systems, as lubricants or in thermal applications.
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- 2022
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