Search

Your search keyword '"Francuz, Tomasz"' showing total 23 results
Start Over Author "Francuz, Tomasz" Publication Year Range Last 3 years
23 results on '"Francuz, Tomasz"'

4. Selected microRNA Expression and Protein Regulator Secretion by Adipose Tissue-Derived Mesenchymal Stem Cells and Metabolic Syndrome.

Author

Wystrychowski, Grzegorz, Simka-Lampa, Klaudia, Witkowska, Agnieszka, Sobecko, Ewelina, Skubis-Sikora, Aleksandra, Sikora, Bartosz, Wojtyna, Ewa, Golda, Agnieszka, Gwizdek, Katarzyna, Wróbel, Marta, Sędek, Łukasz, Górczyńska-Kosiorz, Sylwia, Szweda-Gandor, Nikola, Trautsolt, Wanda, Francuz, Tomasz, Kruszniewska-Rajs, Celina, and Gola, Joanna

Subjects
MESENCHYMAL stem cells, METABOLIC syndrome, BODY mass index, PROTEIN expression, SECRETION, MICRORNA, FAT, HYPERGLYCEMIA
Abstract

The role of adipose mesenchymal stem cells (Ad-MSCs) in metabolic syndrome remains unclear. We aimed to assess the expression of selected microRNAs in Ad-MSCs of non-diabetic adults in relation to Ad-MSC secretion of protein regulators and basic metabolic parameters. Ten obese, eight overweight, and five normal weight subjects were enrolled: 19 females and 4 males; aged 43.0 ± 8.9 years. Ad-MSCs were harvested from abdominal subcutaneous fat. Ad-MSC cellular expressions of four microRNAs (2−ΔCt values) and concentrations of IL-6, IL-10, VEGF, and IGF-1 in the Ad-MSC-conditioned medium were assessed. The expressions of miR-21, miR-122, or miR-192 did not correlate with clinical parameters (age, sex, BMI, visceral fat, HOMA-IR, fasting glycemia, HbA1c, serum lipids, CRP, and eGFR). Conversely, the expression of miR-155 was lowest in obese subjects (3.69 ± 2.67 × 10−3 vs. 7.07 ± 4.42 × 10−3 in overweight and 10.25 ± 7.05 × 10−3 in normal weight ones, p = 0.04). The expression of miR-155 correlated inversely with BMI (sex-adjusted r = −0.64; p < 0.01), visceral adiposity (r = −0.49; p = 0.03), and serum CRP (r = −0.63; p < 0.01), whereas it correlated positively with serum HDL cholesterol (r = 0.51; p = 0.02). Moreover, miR-155 synthesis was associated marginally negatively with Ad-MSC secretion of IGF-1 (r = −0.42; p = 0.05), and positively with that of IL-10 (r = 0.40; p = 0.06). Ad-MSC expression of miR-155 appears blunted in visceral obesity, which correlates with Ad-MSC IGF-1 hypersecretion and IL-10 hyposecretion, systemic microinflammation, and HDL dyslipidemia. Ad-MSC studies in metabolic syndrome should focus on miR-155. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Genetic Variability in VEGFA Gene Influences the Effectiveness of Tennis Elbow Therapy with PRP: A Two-Year Prospective Cohort Study

Author

Niemiec, Paweł, primary, Jarosz, Alicja, additional, Balcerzyk-Matić, Anna, additional, Iwanicka, Joanna, additional, Nowak, Tomasz, additional, Iwanicki, Tomasz, additional, Gierek, Marcin, additional, Kalita, Marcin, additional, Garczorz, Wojciech, additional, Francuz, Tomasz, additional, Górczyńska-Kosiorz, Sylwia, additional, Kania, Wojciech, additional, and Szyluk, Karol, additional

Published
2023
Full Text
View/download PDF

10. The Value of Prolactin, a Panel of Cytokines, and the Soluble Human Epidermal Growth Factor Receptor 2 in the Prediction of Rapid Progression and Shorter Survival during Palliative Chemotherapy of Colorectal Cancer Patients

Author

Cisoń-Jurek, Sylwia, primary, Czajka-Francuz, Paulina, additional, Francuz, Tomasz, additional, Owczarek, Aleksander J., additional, Szymczak, Bożena, additional, Wojnar, Jerzy, additional, and Chudek, Jerzy, additional

Published
2023
Full Text
View/download PDF

16. Predictors of Adverse Outcomes in Healthy Aging Adults: Coronary Artery Disease, Lower Educational Status and Higher P-Selectin Levels

Author

Batko-Szwaczka, Agnieszka, primary, Francuz, Tomasz, additional, Kosowska, Agnieszka, additional, Cogiel, Anna, additional, Dudzińska-Griszek, Joanna, additional, Wilczyński, Krzysztof, additional, Hornik, Beata, additional, Janusz-Jenczeń, Magdalena, additional, Włodarczyk, Iwona, additional, Wnuk, Bartosz, additional, Szołtysek, Joanna, additional, Durmała, Jacek, additional, Dulawa, Jan, additional, and Szewieczek, Jan, additional

Published
2022
Full Text
View/download PDF

17. What Role Does PDGFA Gene Polymorphisms Play in Treating Tennis Elbow with PRP? A Prospective Cohort Study

Author

Jarosz, Alicja, primary, Szyluk, Karol, additional, Iwanicka, Joanna, additional, Balcerzyk, Anna, additional, Nowak, Tomasz, additional, Iwanicki, Tomasz, additional, Negru, Marius, additional, Kalita, Marcin, additional, Francuz, Tomasz, additional, Garczorz, Wojciech, additional, Górczyńska-Kosiorz, Sylwia, additional, Kania, Wojciech, additional, and Niemiec, Paweł, additional

Published
2022
Full Text
View/download PDF

19. Predictors of Adverse Outcomes in Healthy Aging Adults: Coronary Artery Disease, Lower Educational Status and Higher P-Selectin Levels

Author

Batko-Szwaczka,Agnieszka, Francuz,Tomasz, Kosowska,Agnieszka, Cogiel,Anna, Dudzińska-Griszek,Joanna, Wilczyński,Krzysztof, Hornik,Beata, Janusz-Jenczeń,Magdalena, Włodarczyk,Iwona, Wnuk,Bartosz, Szołtysek,Joanna, Durmała,Jacek, Dulawa,Jan, Szewieczek,Jan, Batko-Szwaczka,Agnieszka, Francuz,Tomasz, Kosowska,Agnieszka, Cogiel,Anna, Dudzińska-Griszek,Joanna, Wilczyński,Krzysztof, Hornik,Beata, Janusz-Jenczeń,Magdalena, Włodarczyk,Iwona, Wnuk,Bartosz, Szołtysek,Joanna, Durmała,Jacek, Dulawa,Jan, and Szewieczek,Jan

Abstract

Agnieszka Batko-Szwaczka,1 Tomasz Francuz,2 Agnieszka Kosowska,2 Anna Cogiel,1 Joanna Dudzi&nacute;ska-Griszek,1 Krzysztof Wilczy&nacute;ski,1 Beata Hornik,3 Magdalena Janusz-Jencze&nacute;,3 Iwona W&lstrok;odarczyk,3 Bartosz Wnuk,4 Joanna Szo&lstrok;tysek,4 Jacek Durma&lstrok;a,4 Jan Dulawa,5 Jan Szewieczek1 1Department of Geriatrics, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 2Department of Biochemistry, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 3Department of Internal Nursing, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 4Department of Rehabilitation, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland; 5Department of Internal Medicine and Metabolic Diseases, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, PolandCorrespondence: Agnieszka Batko-Szwaczka, Department of Geriatrics, Faculty of Health Sciences in Katowice, Medical University of Silesia, Poniatowskiego 15, Katowice, 40-055, Poland, Tel +48323598239, Fax +48322059483, Email abatko-szwaczka@sum.edu.plBackground: Societal aging – as a global demographic phenomenon – shows no indication of abating. As a result, the problem of age-associated disability and related long-term care is emerging as a major public health challenge. It is important that methods for identifying older adults at risk of adverse outcomes are implemented early.Methods: The study group consisted of 145 individuals, 44.1% women, who were randomized from community-dwelling 60– 74-year-old adults. A comprehensive geriatric assessment was supplemented with Fried frailty phenotype evaluation and blood tests (including adhesion molecules, matrix metalloproteinases and neurotrophic factors). A follow-up by phone call was made for at least 3 years after the initial examination. Composite endpoint (CE) included f

Published
2022

23. Systemic Interleukins' Profile in Early and Advanced Colorectal Cancer.

Author

Czajka-Francuz, Paulina, Cisoń-Jurek, Sylwia, Czajka, Aleksander, Kozaczka, Maciej, Wojnar, Jerzy, Chudek, Jerzy, and Francuz, Tomasz

Subjects
MYELOID-derived suppressor cells, COLORECTAL cancer, REGULATORY T cells, T helper cells, INTERLEUKINS, T cells, NEUTROPHILS
Abstract

Tumor microenvironment (TME) is characterized by mutual interactions of the tumor, stromal and immune cells. Early and advanced colorectal tumors differ in structure and present altered serum cytokine levels. Mutual crosstalk among TME infiltrating cells may shift the balance into immune suppressive or pro-inflammatory, antitumor response this way influencing patients' prognosis. Cancer-related inflammation affects all the body and this way, the systemic level of cytokines could reflect TME processes. Despite numerous studies, it is still not known how systemic cytokines levels change during colorectal cancer (CRC) tumor development. Better understanding tumor microenvironment processes could help in planning therapeutic interventions and more accurate patient prognosis. To contribute to the comprehension of these processes within TME, we reviewed cytokines levels from clinical trials in early and advanced colorectal cancer. Presented data were analyzed in the context of experimental studies and studies analyzing tumor infiltration with immune cells. The review summarizes clinical data of cytokines secreted by tumor microenvironment cells: lymphocytes T helper 1 (Th1), lymphocytes T helper 2 (Th2), lymphocytes T helper 17 (Th17), regulatory T cells (Treg cells), regulatory T cells (Breg cells), M1/M2 macrophages, N1/N2 neutrophils, myeloid-derived suppressor cells (MDSC), dendritic cells (DC), innate lymphoid cells (ILC) natural killer (NK) cells and tumor cells. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results