1. Airway inflammation induces anxiety-like behavior through neuroinflammatory, neurochemical, and neurometabolic changes in an allergic asthma model
- Author
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Géssica Luana, Antunes, Josiane Silva, Silveira, Carolina, Luft, Samuel, Greggio, Gianina Teribele, Venturin, Felipe, Schmitz, Helena, Biasibetti-Brendler, Francieli, Vuolo, Felipe, Dal-Pizzol, Jaderson Costa, da Costa, Angela T S, Wyse, Paulo Márcio, Pitrez, and Aline Andrea, da Cunha
- Subjects
Inflammation ,Disease Models, Animal ,Mice ,Cellular and Molecular Neuroscience ,Acetylcholinesterase ,Animals ,Neurology (clinical) ,Anxiety ,Biochemistry ,Asthma - Abstract
Allergic asthma is characterized by chronic airway inflammation and is constantly associated with anxiety disorder. Recent studies showed bidirectional interaction between the brain and the lung tissue. However, where and how the brain is affected in allergic asthma remains unclear. We aimed to investigate the neuroinflammatory, neurochemical, and neurometabolic alterations that lead to anxiety-like behavior in an experimental model of allergic asthma. Mice were submitted to an allergic asthma model induced by ovalbumin (OVA) and the control group received only Dulbecco's phosphate-buffered saline (DPBS). Our findings indicate that airway inflammation increases interleukin (IL) -9, IL-13, eotaxin, and IL-1β release and changes acetylcholinesterase (AChE) and Na
- Published
- 2022