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Your search keyword '"França, Victor"' showing total 15 results
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15 results on '"França, Victor"'

8. Tofacitinib and peficitinib inhibitors of Janus kinase for autoimmune disease treatment: a quantum biochemistry approach.

Author

Amaral, Jackson L., Lucredi, Naiara C., França, Victor L. B., Santos, Samuel J. M., Maia Jr, Francisco F., Morais, Pablo A., Souza, Pedro F. N., Comar, Jurandir F., and Freire, Valder N.

Abstract

Autoimmune inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis, are associated with an uncontrolled production of cytokines leading to the pronounced inflammatory response of these disorders. Their therapy is currently focused on the inhibition of cytokine receptors, such as the Janus kinase (JAK) protein family. Tofacitinib and peficitinib are JAK inhibitors that have been recently approved to treat rheumatoid arthritis. In this study, an in-depth analysis was carried out through quantum biochemistry to understand the interactions involved in the complexes formed by JAK1 and tofacitinib or peficitinib. Computational analyses provided new insights into the binding mechanisms between tofacitinib or peficitinib and JAK1. The essential amino acid residues that support the complex are also identified and reported. Additionally, we report new interactions, such as van der Waals; hydrogen bonds; and alkyl, pi-alkyl, and pi-sulfur forces, that stabilize the complexes. The computational results revealed that peficitinib presents a similar affinity to JAK1 compared to tofacitinib based on their interaction energies. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent

Author

Guimarães, Celina de Jesus, primary, Carneiro, Teiliane Rodrigues, additional, Frederico, Marisa Jadna Silva, additional, de Carvalho, Guilherme G. C., additional, Little, Matthew, additional, Freire, Valder N., additional, França, Victor L. B., additional, do Amaral, Daniel Nascimento, additional, Guedes, Jéssica de Siqueira, additional, Barreiro, Eliezer J., additional, Lima, Lídia Moreira, additional, Barros-Nepomuceno, Francisco W. A., additional, and Pessoa, Claudia, additional

Published
2023
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13. Plasma Campesterol Is Positively Associated with Carotid Plaques in Asymptomatic Subjects

Author

Nunes, Valéria Sutti, primary, de Campos, Edite Vieira Silva, additional, Baracat, Jamal, additional, França, Victor, additional, Gomes, Érica Ivana Lázaro, additional, Coelho, Raissa Peres, additional, Nakandakare, Edna Regina, additional, Zago, Vanessa Helena Souza, additional, de Faria, Eliana Cotta, additional, and Quintão, Eder Carlos Rocha, additional

Published
2022
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