179 results on '"Fournier M"'
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2. Démarche diagnostique générale devant un patient présentant des mouvements anormaux : importance des examens biologiques dans cette stratégie
- Author
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De Roquemaurel, A., Gayraud, D., Fournier, M., and Di Legge, S.
- Published
- 2023
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3. Long-run forecasting surface and groundwater dynamics from intermittent observation data: An evaluation for 50 years
- Author
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Vu, M.T., Jardani, A., Massei, N., Deloffre, J., Fournier, M., and Laignel, B.
- Published
- 2023
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4. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
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Marchal, A, Cirulli, E, Neveux, I, Bellos, E, Thwaites, R, Schiabor Barrett, K, Zhang, Y, Nemes-Bokun, I, Kalinova, M, Catchpole, A, Tangye, S, Spaan, A, Lack, J, Ghosn, J, Burdet, C, Gorochov, G, Tubach, F, Hausfater, P, Abel, L, Aiuti, A, Al-Muhsen, S, Al-Mulla, F, Amara, A, Anderson, M, Andreakos, E, Arias, A, Arkin, L, Feldman, H, Bastard, P, Belot, A, Biggs, C, Bogunovic, D, Bolze, A, Bondarenko, A, Borghesi, A, Bousfiha, A, Brodin, P, Bryceson, Y, Butte, M, Casanova, J, Casari, G, Christodoulou, J, Cobat, A, Colobran, R, Condino-Neto, A, Constantinescu, S, Cooper, M, Dalgard, C, Desai, M, Drolet, B, Duval, X, El Baghdadi, J, Eloy, P, Espinosa-Padilla, S, Fellay, J, Flores, C, Franco, J, Froidure, A, Gregersen, P, Grimbacher, B, Haerynck, F, Hagin, D, Halwani, R, Hammarstrom, L, Heath, J, Hsieh, E, Husebye, E, Imai, K, Itan, Y, Jouanguy, E, Kaja, E, Karamitros, T, Kisand, K, Ku, C, Lau, Y, Ling, Y, Lucas, C, Maniatis, T, Mansouri, D, Marodi, L, Mentre, F, Meyts, I, Milner, J, Mironska, K, Mogensen, T, Morio, T, Ng, L, Notarangelo, L, Novelli, A, Novelli, G, O'Farrelly, C, Okada, S, Okamoto, K, Ozcelik, T, Pan-Hammarstrom, Q, Pape, J, Perez de Diego, R, Perez-Tur, J, Perlin, D, Pesole, G, Planas, A, Prando, C, Pujol, A, Puel, A, Quintana-Murci, L, Ramaswamy, S, Renia, L, Resnick, I, Rodriguez-Gallego, C, Sancho-Shimizu, V, Sediva, A, Seppanen, M, Shahrooei, M, Shcherbina, A, Slaby, O, Snow, A, Soler-Palacin, P, Soumelis, V, Tancevski, I, Tayoun, A, Temel, S, Thorball, C, Tiberghien, P, Trouillet-Assant, S, Turvey, S, Uddin, K, Uddin, M, van de Beek, D, Vinh, D, von Bernuth, H, Wauters, J, Zatz, M, Zawadzki, P, Zhang, Q, Zhang, S, Bureau, S, Vacher, Y, Gysembergh-Houal, A, Demerville, L, Benleulmi-Chaachoua, A, Abad, S, Abassi, R, Abdellaoui, A, Abdelmalek, A, Abdoul, H, Abergel, H, Abeud, F, Abgrall, S, Abisror, N, Adechian, M, Aderdour, N, Admane, H, Adnet, F, Afritt, S, Agostini, H, Aguilar, C, Agut, S, Aiello, T, Kaci, M, Oufella, H, Ajeenthiravasan, G, Alauzy, V, Alby-Laurent, F, Allard, L, Alyanakian, M, Borrero, B, Amam, S, Amrouche, L, Andronikof, M, Anglicheau, D, Anguel, N, Annane, D, Aounzou, M, Aparicio, C, Aratus, G, Arlet, J, Arzoine, J, Aslangul, E, Assefi, M, Aubry, A, Audiffred, L, Audureau, E, Auger, C, Auregan, J, Awotar, C, Milla, S, Azan, D, Azemar, L, Azzouguen, B, Elrufaai, M, Badsi, A, Bakouboula, P, Balcerowiak, C, Balde, F, Baldivia, E, Bangamingo, E, Baptiste, A, Baran-Marszak, F, Barau, C, Barget, N, Baronnet, F, Barthelemy, R, Baudel, J, Baudry, C, Baudry, E, Beaugerie, L, Belamri, A, Belaube, N, Belilita, R, Bellassen, P, Belmokhtar, R, Beltran, I, Benainous, R, Benallaoua, M, Benamouzig, R, Benbara, A, Benhida, J, Benkhelouf, A, Benlagha, J, Benmostafa, C, Benothmane, S, Bentifraouine, M, Berard, L, Bernier, Q, Berti, E, Bertier, A, Berton, L, Bessis, S, Beurton, A, Bianco, C, Bianquis, C, Bidar, F, Blanche, P, Blayau, C, Bleibtreu, A, Blin, E, Bloch-Queyrat, C, Boissier, M, Bollens, D, Bolzoni, M, Bompard, R, Bonnet, N, Bonnouvrier, J, Botha, S, Boucenna, W, Bouchama, F, Bouchaud, O, Bouchghoul, H, Boudjebla, T, Boudjema, N, Bouffard, C, Bougle, A, Bouguerra, M, Bouras, L, Bourcier, A, Durand, A, Bourrier, A, Bouscarat, F, Bouvry, D, Bouziri, N, Bouzrara, O, Bribier, S, Brugier, D, Brunel, M, Bui, E, Buisson, A, Bukreyeva, I, Bureau, C, Cadranel, J, Cailhol, J, Calin, R, Vega, C, Canavaggio, P, Cancella, M, Cantin, D, Cao, A, Carbillon, L, Carlier, N, Cassard, C, Castor, G, Cauchy, M, Cha, O, Chaigne, B, Challal, S, Champion, K, Chariot, P, Chas, J, Chauveau, S, Chauvin, A, Chauvin, C, Chavarot, N, Chebbout, K, Cherai, M, Cherubini, I, Chevalier, A, Chiarabini, T, Chinet, T, Chocron, R, Choinier, P, Chommeloux, J, Choquet, C, Choupeaux, L, Chousterman, B, Ciocan, D, Clarke, A, Clavere, G, Clavier, F, Clement, K, Clerc, S, Cohen, Y, Cohen, F, Cohen, A, Coilly, A, Colboc, H, Colin, P, Collet, M, Comarmond, C, Combacon, E, Combes, A, Comparon, C, Constantin, J, Cordel, H, Cordier, A, Costantini, A, Chalumeau, N, Couffignal, C, Coupeau, D, Creange, A, Lamarre, Y, Da Silveira, C, Guibal El Kayani, S, De Castro, N, De Rycke, Y, Del Pozo, L, Delannoy, Q, Delay, M, Deleris, R, Delforge, J, Delphine, L, Demare, N, Demeret, S, Demoule, A, Deniau, A, Depret, F, Derolez, S, Derradji, O, Derridj, N, Descamps, V, Deschamps, L, Desconclois, C, Desnos, C, Desongins, K, Dhote, R, Diallo, B, Didier, M, Diemer, M, Diez, S, Djadi-Prat, J, Djamouri Monnory, F, Djebara, S, Djebra, N, Djietcheu, M, Djillali, H, Djouadi, N, Donneger, S, Santos, C, Dournon, N, Dres, M, Droctove, L, Drogrey, M, Dropy, M, Drouet, E, Dubosq, V, Dubreucq, E, Dubus, E, Duchemann, B, Duchenoy, T, Dudoignon, E, Dufau, R, Dumas, F, Duran, C, Duron, E, Durrbach, A, Duvivier, C, Ebstein, N, El Khalifa, J, Elabbadi, A, Elie, C, Ernotte, G, Esling, A, Etienne, M, Eyer, X, Fartoukh, M, Fayali, T, Fermaut, M, Fiorentino, A, Fliss, S, Fournier, M, Fournier, B, Francois, H, Freynet, O, Frigout, Y, Fromont, I, Fuentes, A, Furet, T, Galand, J, Garnier, M, Gaubert, A, Gaudry, S, Gaugain, S, Gauthier, D, Gautier, M, Georgin-Lavialle, S, Geromin, D, Ghalayini, M, Ghaleh, B, Ghezal, M, Gibelin, A, Gimeno, L, Girard, B, Leprieur, B, Gomes, D, Gomes-Pires, E, Gouge, A, Gouja, A, Goulet, H, Goupil, S, De Bouille, J, Gras, J, Greffe, S, Grimaldi, L, Guedeney, P, Guidet, B, Guillo, M, Gulczynski, M, Hadjam, T, Haguenauer, D, Hammal, S, Hammoudi, N, Hanon, O, Harrois, A, Hautem, C, Hekimian, G, Heming, N, Hermine, O, Ho, S, Houllier, M, Huot, B, Huscenot, T, Saied, W, Ikherbane, G, Imarazene, M, Ingiliz, P, Iratni, L, Jaureguiberry, S, Jean-Marc, J, Jeyarajasingham, D, Jouany, P, Jouis, V, Jourdaine, C, Kafif, O, Kallala, R, Katsahian, S, Kelesyan, L, Keo, V, Ketz, F, Khamis, W, Khelili, E, Khellaf, M, Kotokpo Youkou, C, Kounis, I, Kpalma, G, Krause, J, Labbe, V, Lacombe, K, Lacorte, J, Lafont, A, Lafont, E, Lagha, L, Lamhaut, L, Lancelot, A, Landman, C, Lanternier, F, Larcheveque, C, Combe, C, Lassel, L, Laverdant, B, Lavergne, C, Lavillegrand, J, Lazureanu, P, Le Guennec, L, Leberre, L, Leblanc, C, Leboyer, M, Lecomte, F, Lecorre, M, Leenhardt, R, Lefebvre, M, Lefebvre, B, Legendre, P, Leger, A, Legros, L, Legrosse, J, Lehuunghia, S, Lemarec, J, Leporrier-Ext, J, Lesein, M, Lesur, H, Levy, V, Levy, A, Lopes, E, Lopes, A, Lopez, V, Lopinto, J, Lortholary, O, Louadah, B, Loze, B, Lucas, M, Lucasamichi, A, Luong, L, Magazimama-Ext, A, Maingret, D, Mameri, L, Manivet, P, Mansouri, C, Marcault, E, Marey, J, Marin, N, Marois, C, Martin, O, Martineau, L, Martinez-Lopez, C, Martyniuck, P, De Farcy, P, Marzouk, N, Masmoudi, R, Mebazaa, A, Mechai, F, Mecozzi, F, Mediouni, C, Megarbane, B, Meghadecha, M, Mejean, E, Mekinian, A, Abdelhadi, N, Mekni, R, Meliti, T, Lima, B, Meng, P, Merbah, S, Messani, F, Messaoudi, Y, Mewasing, B, Meziane, L, Michelot-Burger, C, Mignot, F, Minka, F, Miyara, M, Moine, P, Molina, J, Montegnies-Boulet, A, Monti, A, Montlahuc, C, Montout, A, Moores, A, Morbieu, C, Mortelette, H, Mouly, S, Muzaffar, R, Nacerddine, C, Nadal, M, Nadif, H, Nassarmadji, K, Natella, P, Ndingamondze, S, Neraal, S, Nguyen, C, N'Guyen, B, Larmurier, I, Nlomenyengue, L, Noel, N, Nunes, H, Omar, E, Ouazene, Z, Ouedraogo, E, Ouelaa, W, Oukhedouma, A, Amara, Y, Oya, H, Oziel, J, Padilla, T, Paillaud, E, Paiva, S, Parfait, B, Parize, P, Parizot, C, Parrot, A, Pavot, A, Peaudecerf, L, Pene, F, Pepin, M, Pernet, J, Pernin, C, Petit, M, Peyrony, O, Pietri, M, Pietri, O, De Chambrun, M, Pinson, M, Pintado, C, Piquard, V, Pires, C, Planquette, B, Poirier, S, Pomel, A, Pons, S, Ponscarme, D, Pourcelot, A, Pourcher, V, Pouvaret, A, Prever, F, Previlon, M, Prevost, M, Provoost, M, Quemeneur, C, Rafat, C, Rami, A, Ranque, B, Raphael, M, Raphalen, J, Rastoin, A, Raux, M, Rebai, A, Reby, M, Regent, A, Regrag, A, Resche-Rigon, M, Ressaire, Q, Richard, C, Richard, M, Robert, M, Rohaut, B, Rolland-Debord, C, Ropers, J, Roque-Afonso, A, Rosso, C, Rousseaux, M, Rousseaux, N, Roux, S, Roux, L, Rouzaud, C, Rozes, A, Rubenstein, E, Sabate, J, Sabet, S, Sacleux, S, Kermanach, N, Saliba, F, Salmon, D, Savale, L, Savary, G, Sberro, R, Scemla, A, Schlemmer, F, Schwartz, M, Sedfi, S, Sefir-Kribel, S, Seksik, P, Sellier, P, Selves, A, Sembach, N, Semerano, L, Senat, M, Sene, D, Serris, A, Sese, L, Sghiouar, N, Sigaux, J, Siguier, M, Silvain, J, Simon, N, Simon, T, Skandri, L, Slimani, M, Snauwaert, A, Sokol, H, Soliman, H, Soltani, N, Soyer, B, Steg, G, Suarez, L, Szwebel, T, Taffame, K, Tandjaoui-Lambiotte, Y, Tantet, C, Tateo, M, Theodose, I, Thiebaud, P, Thomas, C, Tiercelet, K, Tisserand, J, Tomczak, C, Torelino, K, Touam-Ext, F, Toumi, L, Toury, G, Toy-Miou, M, Dinh Thanh Lien, O, Trandinh, A, Treluyer, J, Trinque, B, Truchot, J, Tubiana, S, Tunesi, S, Turpin, M, Turpin, A, Urbina, T, Narvaez, R, Uzunhan, Y, Vaittinadaayar, P, Valent, A, Valentian, M, Valin, N, Vallet, H, Vaz, M, Vazquezibarra, M, Vedie, B, Velly, L, Verstuyft, C, Viallette, C, Vicaut, E, Vignes, D, Vimpere, D, Virlouvet, M, Voiriot, G, Voisot, L, Weiss, E, Weiss, N, Winchenne, A, Yordanov, Y, Zafrani, L, Zaidan, M, Zaidi, W, Zak, C, Zarhrate-Ghoul, A, Zatout, O, Zeino, S, Zeitouni, M, Zemirli, N, Zerah, L, Zia, O, Ziol, M, Zolario, O, Zuber, J, Andrejak, C, Angoulvant, F, Bachelet, D, Bartoli, M, Basmaci, R, Behillil, S, Beluze, M, Benkerrou, D, Bhavsar, K, Bouadma, L, Bouchez, S, Bouscambert, M, Cervantes-Gonzalez, M, Chair, A, Chirouze, C, Coelho, A, Couffin-Cadiergues, S, D'Ortenzio, E, Debray, M, Deconinck, L, Deplanque, D, Descamps, D, Desvallee, M, Diallo, A, Diouf, A, Dorival, C, Dubos, F, Elharrar, B, Enouf, V, Esperou, H, Esposito-Farese, M, Devouge, E, Gault, N, Gaymard, A, Gigante, T, Gilg, M, Guedj, J, Hoctin, A, Hoffmann, I, Houas, I, Hulot, J, Jaafoura, S, Kaguelidou, F, Kali, S, Khalil, A, Khan, C, Laouenan, C, Laribi, S, Le, M, Le Hingrat, Q, Le Mestre, S, Le Nagard, H, Lescure, F, Letrou, S, Levy, Y, Lina, B, Lingas, G, Lucet, J, Malvy, D, Mambert, M, Meziane, A, Mouquet, H, Mullaert, J, Neant, N, Nguyen, D, Noret, M, Nseir, S, Papadopoulos, A, Paul, C, Peiffer-Smadja, N, Perpoint, T, Petrov-Sanchez, V, Peytavin, G, Pham, H, Picone, O, Puechal, O, Rabaud, C, Rosa-Calatrava, M, Rossignol, B, Rossignol, P, Roy, C, Schneider, M, Su, R, Tardivon, C, Tellier, M, Teoule, F, Terrier, O, Timsit, J, Tual, C, van der Werf, S, Vanel, N, Veislinger, A, Visseaux, B, Wiedemann, A, Yazdanpanah, Y, Alavoine, L, Charpentier, C, Dechanet, A, Ecobichon, J, Frezouls, W, Houhou, N, Lehacaut, J, Manchon, P, Nouroudine, M, Quintin, C, Thy, M, Vignali, V, Chahine, A, Waucquier, N, Migaud, M, Djossou, F, Mergeay-Fabre, M, Lucarelli, A, Demar, M, Bruneau, L, Gerardin, P, Maillot, A, Payet, C, Laviolle, B, Laine, F, Paris, C, Desille-Dugast, M, Fouchard, J, Pistone, T, Perreau, P, Gissot, V, Goas, C, Montagne, S, Richard, L, Bouiller, K, Desmarets, M, Meunier, A, Bourgeon, M, Lefevre, B, Jeulin, H, Legrand, K, Lomazzi, S, Tardy, B, Gagneux-Brunon, A, Bertholon, F, Botelho-Nevers, E, Kouakam, C, Nicolas, L, Roufai, L, Amat, K, Hendou, S, Foti, G, Citerio, G, Contro, E, Pesci, A, Valsecchi, M, Cazzaniga, M, Bellani, G, Abad, J, Accordino, G, Angelini, M, Aguilera-Albesa, S, Aguilo-Cucurull, A, Ozkan, E, Darazam, I, Roblero Albisures, J, Aldave, J, Ramos, M, Khan, T, Aliberti, A, Nadji, S, Alkan, G, Alkhater, S, Allardet-Servent, J, Allende, L, Alonso-Arias, R, Alshahrani, M, Alsina, L, Amoura, Z, Antoli, A, Arrestier, R, Aubart, M, Auguet, T, Avramenko, I, Aytekin, G, Azot, A, Bahram, S, Bajolle, F, Baldanti, F, Baldolli, A, Ballester, M, Barrou, B, Barzaghi, F, Basso, S, Bayhan, G, Bezrodnik, L, Bilbao, A, Blanchard-Rohner, G, Blanco, I, Blandinieres, A, Blazquez-Gamero, D, Bloomfield, M, Bolivar-Prados, M, Borie, R, Botdhlo-Nevers, E, Bousquet, A, Boutolleau, D, Bouvattier, C, Boyarchuk, O, Bravais, J, Briones, M, Brunner, M, Bruno, R, Bueno, M, Bukhari, H, Bustamante, J, Caceres Agra, J, Capra, R, Carapito, R, Carrabba, M, Casasnovas, C, Caseris, M, Cassaniti, I, Castelle, M, Castelli, F, Castillo de Vera, M, Castro, M, Catherinot, E, Celik, J, Ceschi, A, Chalumeau, M, Charbit, B, Boulanger, C, Clave, P, Clotet, B, Codina, A, Comoli, P, Corsico, A, Coskuner, T, Cvetkovski, A, Cyrus, C, Dalmau, D, Danion, F, Darley, D, Das, V, Dauby, N, Dauger, S, De Munte, P, de Pontual, L, Dehban, A, Delplancq, G, Desguerre, I, Di Sabatino, A, Diehl, J, Dobbelaere, S, Dominguez-Garrido, E, Dubost, C, Ekwall, O, Bozdemir, S, Elnagdy, M, Emiroglu, M, Endo, A, Erdeniz, E, Aytekin, S, Etxart Lasa, M, Euvrard, R, Fabio, G, Faivre, L, Falck, A, Faure, M, Arquero, M, Ferrer, R, Ferreres, J, Francois, B, Fumado, V, Fung, K, Fusco, F, Gagro, A, Solis, B, Garcon, P, Gaussem, P, Gayretli, Z, Gil-Herrera, J, Gilardin, L, Gatineau, A, Girona-Alarcon, M, Cifuentes Godinez, K, Goffard, J, Gonzales, N, Gonzalez-Granado, L, Gonzalez-Montelongo, R, Guerder, A, Gulhan, B, Gumucio, V, Hanitsch, L, Gunst, J, Gut, M, Hadjadj, J, Hancerli, S, Hariyan, T, Hatipoglu, N, Heppekcan, D, Hernandez-Brito, E, Ho, P, Holanda-Pena, M, Horcajada, J, Hraiech, S, Humbert, L, Hung, I, Iglesias, A, Inigo-Campos, A, Jamme, M, Arranz, M, Jimeno, M, Jordan, I, Kanik-Yuksek, S, Kara, Y, Karahan, A, Karbuz, A, Yasar, K, Kasapcopur, O, Kashimada, K, Keles, S, Demirkol, Y, Kido, Y, Kizil, C, Kilic, A, Klocperk, A, Koutsoukou, A, Krol, Z, Ksouri, H, Kuentz, P, Kwan, A, Kwan, Y, Kwok, J, Lagier, J, Lam, D, Lampropoulou, V, Le Bourgeois, F, Leo, Y, Lopez, R, Leung, D, Levin, M, Levy, M, Levy, R, Li, Z, Lilleri, D, Adrian Bolanos Lima, E, Linglart, A, Lopez-Collazo, E, Lorenzo-Salazar, J, Louapre, C, Lubetzki, C, Lung, K, Luyt, C, Lye, D, Magnone, C, Marchioni, E, Marioli, C, Marjani, M, Marques, L, Pereira, J, Martin-Nalda, A, Pueyo, D, Martinez-Picado, J, Marzana, I, Mata-Martinez, C, Mathian, A, Matos, L, Matthews, G, Mayaux, J, McLaughlin-Garcia, R, Meersseman, P, Mege, J, Mekontso-Dessap, A, Melki, I, Meloni, F, Meritet, J, Merlani, P, Akcan, O, Mezidi, M, Migeotte, I, Millereux, M, Million, M, Mirault, T, Mircher, C, Mirsaeidi, M, Mizoguchi, Y, Modi, B, Mojoli, F, Moncomble, E, Melian, A, Martinez, A, Morandeira, F, Morange, P, Mordacq, C, Morelle, G, Munoz-Barrera, A, Nafati, C, Nagashima, S, Nakagama, Y, Neven, B, Neves, J, Ng, Y, Hubert, N, Medina, Y, Cuadros, E, Karabela, S, Ocejo-Vinyals, J, Oualha, M, Ouedrani, A, Ozkaya-Parlakay, A, Pagani, M, Papadaki, M, Parola, P, Pascreau, T, Paul, S, Paz-Artal, E, Pedraza, S, Gonzalez Pellecer, N, Pellegrini, S, Perez-Fernandez, X, Philippe, A, Philippot, Q, Picod, A, Pineton de Chambrun, M, Piralla, A, Planas-Serra, L, Ploin, D, Poissy, J, Poncelet, G, Poulakou, G, Pouletty, M, Pourshahnazari, P, Qiu-Chen, J, Quentric, P, Rambaud, T, Raoult, D, Raoult, V, Rebillat, A, Redin, C, Resmini, L, Ricart, P, Richard, J, Rigo-Bonnin, R, Rivet, N, Riviere, J, Rocamora-Blanch, G, Rodero, M, Rodrigo, C, Rodriguez, L, Rodriguez-Palmero, A, Romero, C, Rothenbuhler, A, Roux, D, Rovina, N, Rozenberg, F, Ruch, Y, Ruiz, M, Ruiz del Prado, M, Ruiz-Rodriguez, J, Sabater-Riera, J, Saks, K, Salagianni, M, Sanchez, O, Sanchez-Montalva, A, Sanchez-Ramon, S, Schidlowski, L, Schluter, A, Schmidt, J, Schmidt, M, Schuetz, C, Schweitzer, C, Scolari, F, Seijo, L, Seminario, A, Seng, P, Senoglu, S, Llovich, A, Siguret, V, Siouti, E, Smadja, D, Smith, N, Sobh, A, Solanich, X, Sole-Violan, J, Soler, C, Sozeri, B, Stella, G, Stepanovskiy, Y, Stoclin, A, Taccone, F, Taupin, J, Tavernier, S, Tello, L, Terrier, B, Thiery, G, Thorn, K, Thumerelle, C, Tipu, I, Tolstrup, M, Tomasoni, G, Toubiana, J, Alvarez, J, Triantafyllia, V, Troya, J, Tsang, O, Tserel, L, Tso, E, Tucci, A, Tuter Oz, S, Ursini, M, Utsumi, T, Vabres, P, Valencia-Ramos, J, Van Den Rym, A, Vandernoot, I, Velez-Santamaria, V, Zuniga Veliz, S, Vidigal, M, Viel, S, Villain, C, Vilaire-Meunier, M, Villar-Garcia, J, Vincent, A, Van der Linden, D, Volokha, A, Vuotto, F, Wauters, E, Wu, A, Wu, T, Yahsi, A, Yesilbas, O, Yildiz, M, Young, B, Yukselmis, U, Zecca, M, Zuccaro, V, 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- Abstract
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
- Published
- 2024
5. Past activity of Sgr A* is unlikely to affect the local cosmic-ray spectrum up to the TeV regime
- Author
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Fournier, M., primary, Fensch, J., additional, and Commerçon, B., additional
- Published
- 2024
- Full Text
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6. Factors associated with enrolment in clinical trials among women with early-stage breast cancer
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Presti, D., Havas, J., Soldato, D., Lapidari, P., Martin, E., Pistilli, B., Jouannaud, C., Emile, G., Rigal, O., Fournier, M., Soulie, P., Mouret-Reynier, M.-A., Tarpin, C., Campone, M., Guillermet, S., Martin, A.-L., Everhard, S., and Di Meglio, A.
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- 2022
- Full Text
- View/download PDF
7. Solid sorbents for gaseous iodine capture and their conversion into stable waste forms
- Author
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Pénélope, R., Campayo, L., Fournier, M., Gossard, A., and Grandjean, A.
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- 2022
- Full Text
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8. Silver-phosphate glass matrix for iodine conditioning: From sorbent design to vitrification
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Pénélope, R., Campayo, L., Fournier, M., Gossard, A., and Grandjean, A.
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- 2022
- Full Text
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9. Nontargeted Screening of Air Samples Using Td-Gc-Hrms to Identify Volatile Compounds as Markers of an Industrial Plant Fire in Rouen, France
- Author
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Legeard, Tiffen, primary, Tisse, Severine, additional, Vaccaro, Marie, additional, Moufarrej, Lamia, additional, Mignot, Melanie, additional, Castilla, Clément, additional, Schmitz, Isabelle, additional, Portet-Koltalo, Florence, additional, Méausoone, Clémence, additional, Monteil, Christelle, additional, Fournier, M., additional, and Cardinael, Pascal, additional
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- 2024
- Full Text
- View/download PDF
10. CO184 Exploring the Relationship Between Surrogate and Long-Term Outcomes in Lysosomal Storage Diseases: A Targeted Literature Review
- Author
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Palli, J.M., primary, Raygude, K., additional, Fournier, M., additional, Rodriguez, M.B., additional, Lyn, N., additional, Rochmann, C., additional, Pollissard, L., additional, Laredo, F., additional, and Pulikottil-Jacob, R., additional
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- 2023
- Full Text
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11. Étude des points de tolérance et du rôle de BAFF lors de la reconstitution lymphocytaire B au cours du lupus systémique
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Cariou, P.L., primary, Fournier, M., additional, Costedoat-Chalumeau, N., additional, Azzaoui, I., additional, Vandenberghe, A., additional, Sokal, A., additional, Chappert, P., additional, Amoura, Z., additional, Mahevas, M., additional, and Crickx, E., additional
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- 2023
- Full Text
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12. EPH85 Clinical Burden of GM2 Gangliosidoses in the United States (US): A Retrospective Observational Cohort Study Using Electronic Health Records (EHR)
- Author
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Rodriguez, M.B., primary, Petruski-Ivleva, N., additional, Pulikottil-Jacob, R., additional, Batsu, I., additional, Flores, A.L., additional, Fournier, M., additional, Kissell, J., additional, Zheng, R., additional, Madziva, D., additional, Umarje, S., additional, and Tifft, C.J., additional
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- 2023
- Full Text
- View/download PDF
13. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
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B., Bourrier A., Bouscarat F., Bouvry D., Bouziri N., Bouzrara O., Bribier S., Brugier D., Brunel M., Bui E., Buisson A., Bukreyeva I., Bureau C., Cadranel J., Cailhol J., Calin R., Vega C. C., Canavaggio P., Cancella M., Cantin D., Cao A., Carbillon L., Carlier N., Cassard C., Castor G., Cauchy M., Cha O., Chaigne B., Challal S., Champion K., Chariot P., Chas J., Chauveau S., Chauvin A., Chauvin C., Chavarot N., Chebbout K., Cherai M., Cherubini I., Chevalier A., Chiarabini T., Chinet T., Chocron R., Choinier P., Chommeloux J., Choquet C., Choupeaux L., Chousterman B., Ciocan D., Clarke A., Clavere G., Clavier F., Clement K., Clerc S., Cohen Y., Cohen F., Cohen A., Coilly A., Colboc H., Colin P., Collet M., Comarmond C., Combacon E., Combes A., Comparon C., Constantin J. -M., Cordel H., Cordier A. -G., Costantini A., Chalumeau N. C., Couffignal C., Coupeau D., Creange A., Lamarre Y. C., Da Silveira C., Kayani S. D. G. 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M., Smith N., Solanich X., Sole-Violan J., Soler C., Stella G. M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J. -L., Tavernier S. J., Tello L. V., Terrier B., Thiery G., Thorball C., Thorn K., Thumerelle C., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J. T., Triantafyllia V., Trouillet-Assant S., Tsang O. T. Y., Tserel L., Tso E. Y. K., Tucci A., Oz S. K. T., Ursini M. V., Utsumi T., Vabres P., Valencia-Ramos J., Van Den Rym A. M., Vandernoot I., Velez-Santamaria V., Veliz S. P. Z., Vidigal M. C., Viel S., Villain C., Vilaire-Meunier M. E., Villar-Garcia J., Vincent A., Volokha A., Vuotto F., Wauters E., Wauters J., Wu A. K. L., Wu T. -C., Yahsi A., Yesilbas O., Yildiz M., Young B. E., Yukselmis U., Zecca M., Zuccaro V., Van Praet J., Lambrecht B. N., Van Braeckel E., Bosteels C., Hoste L., Hoste E., Bauters F., De Clercq J., Heijmans C., Slabbynck H., Naesens L., Florkin B., Boulanger C., Vanderlinden D., Berkell M., Carelli V., Malhotra S., Mattiaccio A., Pippucci T., Seri M., Tacconelli E., van Agtmael M., Algera A. G., Appelman B., van Baarle F., Bax D., Beudel M., Bogaard H. J., Bomers M., Bonta P., Bos L., Botta M., de Brabander J., de Bree G., de Bruin S., Buis D. T. P., Bugiani M., Bulle E., Cloherty O. C. A., Dijkstra M., Dongelmans D. A., Dujardin R. W. G., Elbers P., Fleuren L., Geijtenbeek S. G. T., Girbes A., Goorhuis B., Grobusch M. P., Hafkamp F., Hagens L., Hamann J., Harris V., Hemke R., Heunks S. M. H. L., Hollmann M., Horn J., Hovius J. W., de Jong M. D., Koning R., Lim E. H. T., van Mourik N., Nellen J., Nossent E. J., Paulus F., Peters E., Pina-Fuentes D. A. I., van der Poll T., Preckel B., Prins J. M., Raasveld J., Reijnders T., de Rotte M. C. F. J., Schinkel M., Schultz M. J., Schrauwen F. A. P., Schuurmans A., Schuurmans J., Sigaloff K., Slim M. A., Smeele P., Smit M., Stijnis C. S., Stilma W., Teunissen C., Thoral P., Tsonas A. M., Tuinman P. R., van der Valk M., Veelo D., Volleman C., de Vries H., Vught L. A., van Vugt M., Wouters D., Zwinderman A. H., Brouwer M. C., Wiersinga W. J., Vlaar A. P. J., Tompkins M. F., Alba C., Hupalo D. N., Rosenberger J., Sukumar G., Wilkerson M. D., Zhang X., Lack J., Oler A. J., Dobbs K., Danielson J. J., Biondi A., Bettini L. R., D'Angio' M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C., Meyts I., Zhang S. -Y., Puel A., Notarangelo L. D., Boisson-Dupuis S., Su H. C., Boisson B., Jouanguy E., Zhang Q., Abel L., and Cobat A.
- Abstract
Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.
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- 2023
14. B-012 Validation of a Urine Ammonium Assay on Roche Cobas c502 Chemistry Analyzer
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Song, L, primary, Tong, K H, additional, and Fournier, M I, additional
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- 2023
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15. Multi-timescale dynamics of extreme river flood and storm surge interactions in relation with large-scale atmospheric circulation: Case of the Seine estuary
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Turki, E.I., primary, Deloffre, J., additional, Lecoq, N., additional, Gilbert, R., additional, Mendoza, E.T., additional, Laignel, B., additional, Salameh, E., additional, Gutierrez Barcelo, A.D., additional, Fournier, M., additional, and Massei, N., additional
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- 2023
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16. First (e,e) coincidence measurements on solvated sodium benzoate in water using a magnetic bottle time-of-flight spectrometer
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Huart, L., primary, Fournier, M., additional, Dupuy, R., additional, Vacheresse, R., additional, Mailhiot, M., additional, Cubaynes, D., additional, Céolin, D., additional, Hervé du Penhoat, M. A., additional, Renault, J. P., additional, Guigner, J.-M., additional, Kumar, A., additional, Lutet-Toti, B., additional, Bozek, J., additional, Ismail, I., additional, Journel, L., additional, Lablanquie, P., additional, Penent, F., additional, Nicolas, C., additional, and Palaudoux, J., additional
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- 2023
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17. Lead-vanadate sorbents for iodine trapping and their conversion into an iodoapatite-based conditioning matrix
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Pénélope, R., primary, Campayo, L., additional, Fournier, M., additional, Le Gallet, S., additional, Gossard, A., additional, and Grandjean, A., additional
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- 2022
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18. CO20 Predicted Time to Wheelchair and Ventilation Events Comparing Avalglucosidase Alfa (AVA) Versus (vs) Alglucosidase Alfa (ALG) Using a Model of Late-Onset Pompe Disease (LOPD)
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Fournier, M, primary, Caro, JJ, additional, Coughlan, A, additional, Wilson, K, additional, Roberts, M, additional, van der Ploeg, AT, additional, Kruijshaar, ME, additional, Berger, KI, additional, and Pollissard, L, additional
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- 2022
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19. KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity
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Fournier, M, Rodrigue, A, Milano, L, Bleuyard, J-Y, Couturier, AM, Wall, J, Ellins, J, Hester, S, Smerdon, SJ, Tora, L, Masson, J-Y, and Esashi, F
- Subjects
DNA Repair ,General Immunology and Microbiology ,Tumor Suppressor Proteins ,General Neuroscience ,Genome Integrity & Repair ,Acetylation ,General Medicine ,Chromatin ,General Biochemistry, Genetics and Molecular Biology ,Nucleosomes ,Signalling & Oncogenes ,Cell Cycle & Chromosomes ,Structural Biology & Biophysics ,DNA Damage - Abstract
The tumour suppressor PALB2 stimulates RAD51-mediated homologous recombination (HR) repair of DNA damage, whilst its steady-state association with active genes protects these loci from replication stress. Here, we report that the lysine acetyltransferases 2A and 2B (KAT2A/2B, also called GCN5/PCAF), two well-known transcriptional regulators, acetylate a cluster of seven lysine residues (7K-patch) within the PALB2 chromatin association motif (ChAM) and, in this way, regulate context-dependent PALB2 binding to chromatin. In unperturbed cells, the 7K-patch is targeted for KAT2A/2B-mediated acetylation, which in turn enhances the direct association of PALB2 with nucleosomes. Importantly, DNA damage triggers a rapid deacetylation of ChAM and increases the overall mobility of PALB2. Distinct missense mutations of the 7K-patch render the mode of PALB2 chromatin binding, making it either unstably chromatin-bound (7Q) or randomly bound with a reduced capacity for mobilisation (7R). Significantly, both of these mutations confer a deficiency in RAD51 foci formation and increase DNA damage in S phase, leading to the reduction of overall cell survival. Thus, our study reveals that acetylation of the ChAM 7K-patch acts as a molecular switch to enable dynamic PALB2 shuttling for HR repair while protecting active genes during DNA replication.
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- 2022
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20. 1818MO Development and validation of a predictive model of aromatase inhibitor musculoskeletal toxicity (AIMT) among patients (pts) with early breast cancer (EBC)
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Lapidari, P., Lustberg, M., Havas, J., Pagliuca, M., Bousrih, C., Jouannaud, C., Fournier, M., Jacot, W., Vanlemmens, L., Kaderbhai, C., Tredan, O., Levy, C., Martin, A-L., Gaudin, C., Menvielle, G., Franzoi, M.A., Vaz Luis, I.V., and Di Meglio, A.
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- 2024
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21. MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver
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Gjorgjieva, M., Ay, A.S., Correia de Sousa, M., Delangre, E., Dolicka, D., Sobolewski, C., Maeder, C., Fournier, M., Sempoux, C., and Foti, M.
- Subjects
Fatty Liver ,Disease Models, Animal ,Mice ,MicroRNAs ,Animals ,Carcinogenesis/genetics ,Carcinoma, Hepatocellular/pathology ,Diethylnitrosamine/adverse effects ,Fatty Liver/pathology ,Humans ,Liver Neoplasms/pathology ,MicroRNAs/genetics ,MicroRNAs/metabolism ,Proteome ,Thrombospondins ,Thrombospondin-1 ,hepatocellular carcinoma ,metabolism ,miR-22 ,microRNA ,non-alcoholic fatty liver disease ,Carcinoma, Hepatocellular ,Carcinogenesis ,Liver Neoplasms ,Diethylnitrosamine - Abstract
MiR-22 is mostly considered as a hepatic tumor-suppressor microRNA based on in vitro analyses. Yet, whether miR-22 exerts a tumor-suppressive function in the liver has not been investigated in vivo. Herein, in silico analyses of miR-22 expression were performed in hepatocellular carcinomas from human patient cohorts and different mouse models. Diethylnitrosamine-induced hepatocellular carcinomas were then investigated in lean and diet-induced obese miR-22-deficient mice. The proteome of liver tissues from miR-22-deficient mice prior to hepatocellular carcinoma development was further analyzed to uncover miR-22 regulated factors that impact hepatocarcinogenesis with miR-22 deficiency. MiR-22 downregulation was consistently observed in hepatocellular carcinomas from all human cohorts and mouse models investigated. The time of appearance of the first tumors was decreased and the number of tumoral foci induced by diethylnitrosamine was significantly increased by miR-22-deficiency in vivo, two features which were further drastically exacerbated with diet-induced obesity. At the molecular level, we provide evidence that the loss of miR-22 significantly affects the energetic metabolism and mitochondrial functions of hepatocytes, and the expression of tumor-promoting factors such as thrombospondin-1. Our study demonstrates that miR-22 acts as a hepatic tumor suppressor in vivo by restraining pro-carcinogenic metabolic deregulations through pleiotropic mechanisms and the overexpression of relevant oncogenes.
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- 2022
22. S295: CLINICAL RELEVANCE OF SPLEEN VOLUME AND PLATELET COUNT WITH BLEEDING EVENTS IN PATIENTS WITH ACID SPHINGOMYELINASE DEFICIENCY (ASMD)
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Fournier, M., primary, Msihid, J., additional, Willemze, A., additional, Laredo, F., additional, and Pulikottil-Jacob, R., additional
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- 2022
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23. Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia
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Khadimallah, I, Jenni, R, Cabungcal, J-H, Cleusix, M, Fournier, M, Beard, E, Klauser, P, Knebel, J-F, Murray, MM, Retsa, C, Siciliano, M, Spencer, KM, Steullet, P, Cuenod, M, Conus, P, Do, KQ, Khadimallah, I, Jenni, R, Cabungcal, J-H, Cleusix, M, Fournier, M, Beard, E, Klauser, P, Knebel, J-F, Murray, MM, Retsa, C, Siciliano, M, Spencer, KM, Steullet, P, Cuenod, M, Conus, P, and Do, KQ
- Abstract
Early detection and intervention in schizophrenia requires mechanism-based biomarkers that capture neural circuitry dysfunction, allowing better patient stratification, monitoring of disease progression and treatment. In prefrontal cortex and blood of redox dysregulated mice (Gclm-KO ± GBR), oxidative stress induces miR-137 upregulation, leading to decreased COX6A2 and mitophagy markers (NIX, Fundc1, and LC3B) and to accumulation of damaged mitochondria, further exacerbating oxidative stress and parvalbumin interneurons (PVI) impairment. MitoQ, a mitochondria-targeted antioxidant, rescued all these processes. Translating to early psychosis patients (EPP), blood exosomal miR-137 increases and COX6A2 decreases, combined with mitophagy markers alterations, suggest that observations made centrally and peripherally in animal model were reflected in patients' blood. Higher exosomal miR-137 and lower COX6A2 levels were associated with a reduction of ASSR gamma oscillations in EEG. As ASSR requires proper PVI-related networks, alterations in miR-137/COX6A2 plasma exosome levels may represent a proxy marker of PVI cortical microcircuit impairment. EPP can be stratified in two subgroups: (a) a patients' group with mitochondrial dysfunction "Psy-D", having high miR-137 and low COX6A2 levels in exosomes, and (b) a "Psy-ND" subgroup with no/low mitochondrial impairment, including patients having miR-137 and COX6A2 levels in the range of controls. Psy-D patients exhibited more impaired ASSR responses in association with worse psychopathological status, neurocognitive performance, and global and social functioning, suggesting that impairment of PVI mitochondria leads to more severe disease profiles. This stratification would allow, with high selectivity and specificity, the selection of patients for treatments targeting brain mitochondria dysregulation and capture the clinical and functional efficacy of future clinical trials.
- Published
- 2022
24. Gene set enrichment analysis of pathophysiological pathways highlights oxidative stress in psychosis.
- Author
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Pistis, G, Vázquez-Bourgon, J, Fournier, M, Jenni, R, Cleusix, M, Papiol, S, Smart, SE, Pardiñas, AF, Walters, JTR, MacCabe, JH, Kutalik, Z, Conus, P, Crespo-Facorro, B, Q Do, K, Pistis, G, Vázquez-Bourgon, J, Fournier, M, Jenni, R, Cleusix, M, Papiol, S, Smart, SE, Pardiñas, AF, Walters, JTR, MacCabe, JH, Kutalik, Z, Conus, P, Crespo-Facorro, B, and Q Do, K
- Abstract
Polygenic risk prediction remains an important aim of genetic association studies. Currently, the predictive power of schizophrenia polygenic risk scores (PRSs) is not large enough to allow highly accurate discrimination between cases and controls and thus is not adequate for clinical integration. Since PRSs are rarely used to reveal biological functions or to validate candidate pathways, to fill this gap, we investigated whether their predictive ability could be improved by building genome-wide (GW-PRSs) and pathway-specific PRSs, using distance- or expression quantitative trait loci (eQTLs)- based mapping between genetic variants and genes. We focused on five pathways (glutamate, oxidative stress, GABA/interneurons, neuroimmune/neuroinflammation and myelin) which belong to a critical hub of schizophrenia pathophysiology, centred on redox dysregulation/oxidative stress. Analyses were first performed in the Lausanne Treatment and Early Intervention in Psychosis Program (TIPP) study (n = 340, cases/controls: 208/132), a sample of first-episode of psychosis patients and matched controls, and then validated in an independent study, the epidemiological and longitudinal intervention program of First-Episode Psychosis in Cantabria (PAFIP) (n = 352, 224/128). Our results highlighted two main findings. First, GW-PRSs for schizophrenia were significantly associated with early psychosis status. Second, oxidative stress was the only significantly associated pathway that showed an enrichment in both the TIPP (p = 0.03) and PAFIP samples (p = 0.002), and exclusively when gene-variant linking was done using eQTLs. The results suggest that the predictive accuracy of polygenic risk scores could be improved with the inclusion of information from functional annotations, and through a focus on specific pathways, emphasizing the need to build and study functionally informed risk scores.
- Published
- 2022
25. Coupling a magnetic bottle multi-electron spectrometer with a liquid micro-jet device:a comprehensive study of solvated sodium benzoate at the O 1 s threshold
- Author
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Fournier, M. (Marine), Huart, L. (Lucie), Dupuy, R. (Rémi), Vacheresse, R. (Régis), Reinhardt, M. (Maximilian), Cubaynes, D. (Denis), Céolin, D. (Denis), du Penhoat, M. H. (Marie-Anne Hervé), Renault, J.-P. (Jean-Philippe), Guigner, J.-M. (Jean-Michel), Kumar, A. (Ajit), Lutet-Toti, B. (Bastien), Bozek, J. (John), Ismail, I. (Iyas), Journel, L. (Loïc), Lablanquie, P. (Pasca), Penent, F. (Francis), Nicolas, C. (Christophe), Palaudoux, J. (Jérôme), Fournier, M. (Marine), Huart, L. (Lucie), Dupuy, R. (Rémi), Vacheresse, R. (Régis), Reinhardt, M. (Maximilian), Cubaynes, D. (Denis), Céolin, D. (Denis), du Penhoat, M. H. (Marie-Anne Hervé), Renault, J.-P. (Jean-Philippe), Guigner, J.-M. (Jean-Michel), Kumar, A. (Ajit), Lutet-Toti, B. (Bastien), Bozek, J. (John), Ismail, I. (Iyas), Journel, L. (Loïc), Lablanquie, P. (Pasca), Penent, F. (Francis), Nicolas, C. (Christophe), and Palaudoux, J. (Jérôme)
- Abstract
We have developed a magnetic bottle time-of-flight electron-electron coincidence spectrometer to perform measurements on solvated molecules in a liquid micro-jet. We present here the first results obtained after ionization of the oxygen 1s inner-shell of sodium benzoate molecules and show the possibilities to filter out the electron signal arising from the liquid phase from the signal of water molecules in the gas phase. Both photoelectrons and Auger electrons spectra (unfiltered and filtered) are presented.
- Published
- 2022
26. Corrigendum to ‘Silver-phosphate glass matrix for iodine conditioning: From sorbent design to vitrification’: [Journal of Nuclear Materials 558 (2022) 153352]
- Author
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Pénélope, R., Campayo, L., Fournier, M., Gossard, A., and Grandjean, A.
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- 2022
- Full Text
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27. POS0953 IMPACT OF A WEARABLE ACTIVITY TRACKER ON DISEASE ACTIVITY IN SPONDYLOARTHRITIS: A RANDOMIZED CONTROLLED TRIAL
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Labat, G., primary, Hayotte, M., additional, Brocq, O., additional, Bailly, L., additional, Fabre, R., additional, Fournier, M., additional, Breuil, V., additional, D’arripe Longueville, F., additional, and Roux, C., additional
- Published
- 2022
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28. Saltwater intrusion impacts microbial diversity and function in groundwater ecosystems
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Houghton, K. M., Fournier, M., and Tschritter, C.
- Subjects
Toxicity ,Salt ,Groundwater ,Chloride ,Ecosystems ,Microbial Diversity - Abstract
Journal manuscript to be submitted Microbial communities in groundwater carry out biochemical processes which are essential ecosystem functions, such as nutrient cycling and removal of contaminants. The effects of increasing salinity from rising sea level, or over-abstraction, on these microbes are unknown. This study uses a combination of culture dependent (growth curves, isolation of bacteria) and culture-independent (16S rRNA gene sequencing) methods to identify the potential effects of saltwater intrusion on groundwater microbes and their ecosystem functions.
- Published
- 2022
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29. DIY-LOL - Prototypage d’un outil de diagnostic moléculaire démocratisable pour une gestion durable des adventices. Innovations Agronomiques 85, 121-129
- Author
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Mohamadi, F., Valade, R., Bonin, L., Fournier, M., Moreau, F., Ougen, P., Cohan, J., and Délye, C.
- Published
- 2022
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30. PSDR4 FARMaine - les fonds de vallées agricoles au défi des politiques publiques d’environnement. Innovations Agronomiques 86, 81-90
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Fournier, M., Bonnefond, M., Debray, A., Follin, J.-M., Thommeret, N., Botrel, E., Thareau, B., Ben Arfa, N., Pech, M., Fortunel, F., and Dagron, P.
- Published
- 2022
- Full Text
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31. Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry
- Author
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Jackson, Alice M., Petrie, Mark C., Frogoudaki, Alexandra, Laroche, Cécile, Gustafsson, Finn, Ibrahim, Bassem, Mebazaa, Alexandre, Johnson, Mark R., Seferovic, Petar M., Regitz‐Zagrosek, Vera, Mbakwem, Amam, Böhm, Michael, Prameswari, Hawani Sasmaya, Abdel Gawad, Doaa Ahmed Fouad, Goland, Sorel, Damasceno, Albertino, Karaye, Kamilu, Farhan, Hasan Ali, Hamdan, Righab, Maggioni, Aldo P., Sliwa, Karen, Bauersachs, Johann, Meer, Peter, Favaloro, R., Favaloro, L., Carballo, M., Peradejordi, M., Renedo, M.F., Absi, D., Bertolotti, A., Ratto, R., Talavera, M.L., Gomez, R., Lockwood, S., Barton, T., Austin, M‐A., Arstall, M., Aldridge, E., Chow, Y.Y., Dekker, G., Mahadavan, G., Rose, J., Wittwer, M., Hoppe, U., Sandhofer, A., Bahshaliyev, A., Gasimov, Z., Babayev, A., Niftiyev, P., Hasanova, I., AlBannay, R., AlHaiki, W., Husain, A., Mahdi, N., Kurlianskaya, A., Lukyanchyk, M., Shatova, O., Troyanova‐Shchutskaia, T., Anghel, L., De Pauw, M., Gevaert, S., De Backer, J., De Hosson, M., Vervaet, P., Timmermans, P.J., Janssen, A., Yameogo, N.V., Kagambega, L.J., Cumyn, A., Caron, N., Cote, A‐M., Sauve, N., Nkulu, D. Ngoy, Lez, D. Malamba, Yolola, E. Ngoy, Krejci, J., Poloczkova, H., Ersboll, A., Gustafsson, F., Elrakshy, Y., Hassanein, M., Hammad, B., Eldin, O. Nour, Fouad, D., Salman, S., Zareh, Z., Abdeall, D., Elenin, H. Abo, Ebaid, H., El Nagar, A., Farag, S., Saed, M., El Rahman, Y H Abd, Ibrahim, B.S., Abdelhamid, M., Hanna, R.N. W., Youssef, G., Awad, R., Botrous, O.L. I., Halawa, S. Ibrahim, Nasr, G., Saad, A., El Tahlawi, M., Abdelbaset, M., El‐saadawy, M., El‐shorbagy, A., Shalaby, G., Anttonen, O., Tolppanen, H., Hamekoski, S., Menez, T., Noel, A., Lamblin, N., Mouquet, F., Coulon, C., Groote, P., Langlois, S., Schurtz, G., Cohen‐Solal, A., Mebazaa, A., Fournier, M‐C., Louadah, B., Akrout, N., Logeart, D., Leurent, G., Jovanova, S., Arnaudova‐Dezulovicj, F., Livrinova, V., Bauersachs, J., Hilfiker‐Kleiner, D., Berliner, D., Jungesblut, M., Koenig, T., Moulig, V.A., Pfeffer, T.J., Böhm, M., Kindermann, I., Schwarz, V., Schmitt, C., Swojanowsky, P., Pettit, S., Petrie, M., McAdam, M., Patton, D., Bakhai, A., Krishnamurthy, V., Lim, L., Clifford, P., Bowers, N., Clark, A. L., Witte, K., Cullington, D., Oliver, J., Simms, A., Mcginlay, M., McDonagh, T., Shah, A. M., Amin‐Youssef, G., De Courcey, J., Martin, K., Shaw, S., Vause, S., Wallace, S., Malin, G., Wick, C., Nikolaou, M., Rentoukas, I., Chinchilla, H., Andino, L., Iyengar, S., Chandra, S., Yadav, D.K., Babu, R. Ravi, Singh, A.K., Kumar, S., Karunamay, B.B., Chaubey, S.K., Dhiman, S.R., Jha, V.C., Singh, S.K., Kodati, D., Dasari, R., Sultana, S., Dewi, T.I., Prameswari, H. Sasmaya, Al‐Farhan, H.A., Al‐Hussein, A., Yaseen, I.F., Al‐Azzawi, Falah, Al‐Saedi, Ghazi, Mahmood, G.M., Mohammed, M.K., Ridha, A.F., Shotan, A., Vazan, A., Goland, S., Biener, M., Senni, M., Grosu, A., Martin, E., Esposti, D. Degli, Bacchelli, S., Borghi, C., Metra, M., Sciatti, E., Orabona, R., Sani, F., Brunetti, N.D., Sinagra, G., Bobbo, M., D'Agata Mottolese, B., Gesuete, V., Rakar, S., Ramani, F., Kamiya, C., Barasa, A., Ngunga, M., Bajraktari, G., Hyseni, V., Lleshi, D., Pllana, E., Pllana, T., Noruzbaeva, A., Ismailov, F., Mirrakhimov, E., Abilova, S., Lunegova, O., Kerimkulova, A., Osmankulova, G., Duishenalieva, M., Kurmanbekova, B., Turgunov, M., Mamasaidova, S., Bektasheva, E., Kavoliuniene, A., Muckiene, G., Vaitiekiene, A., Celutkiene, J., Balkevicine, L., Barysiene, J., Chee, K.H., Damasceno, A., Machava, M., Veldhuisen, D.J., Meer, P., Berg, M., Roos‐Hesselink, J., Hagen, I., Baris, L., Hurtado, P., Ezeonu, P., Isiguzo, G., Obeka, N., Onoh, R., Asogwa, F., Onyema, C., Otti, K., Ojji, D., Odili, A., Nwankwo, A., Karaye, K., Ishaq, N., Sanni, B., Abubakar, H., Mohammed, B., Sani, M., Kehinde, M., Mbakwem, A., Afolabi, B., Amadi, C., Kilasho, M., Qamar, N., Furnaz, S., Gurmani, S., Kayani, M.G.A. Mahmood, Munir, R., Hussain, S., Malik, S., Mumtaz, S., Saligan, J.R., Rubis, P., Biernacka‐Fijalkowska, B., Lesniak‐Sobelga, A., Wisniowska‐Smialek, S., Kasprzak, J.D., Lelonek, M., Zycinski, P., Jankowski, L., Grajek, S., Oko‐Sarnowska, Z., Rutkowska, A. Bartczak, Kaluzna‐Oleksy, M., Plaskota, K., Demkow, M., Dzielinska, Z., Henzel, J., Kryczka, K., Moiseeva, O., Irtyuga, O., Karelkina, E., Zazerskaya, I., Seferovic, P.M., Milinkovic, I., Živkovic, I., Ristic, A.D., Milasinovic, D., Kong, W. KF, Tan, L.K., Tan, J.L., Thain, S., Poh, K.K., Yip, J., Sliwa, K., Azibani, F., Hovelmann, J., Viljoen, C., Briton, O., Zamora, E., Orcajo, N. Alonso, Carbonell, R., Pascual, C., Muncharaz, J. Farre, Alonso‐Pulpon, L., Cubero, J. Segovia, Urquia, M. Taibo, Garcia‐Pavia, P., Gomez‐Bueno, M., Cobo‐Marcos, M., Briceno, A., Galvan, E. De Teresa, Garcia‐Pinilla, J.M., Robles‐Mezcua, A., Morcillo‐Hildalgo, L., Elbushi, A., Suliman, A., Ahamed, N., Jazzar, K., Murtada, M., Schaufelberger, M., Goloskokova, V., Hullin, R., Yarol, N., Arrigo, M., Cavusoglu, Y., Eraslan, S., Fak, A.S., Enar, S. Catirli, Sarac, L., Cankurtaran, B., Gumrukcuoglu, H., Ozturk, F., Omagino, J., Mondo, C., Lwabi, P., Ingabire, P., Nabbaale, J., Nyakoojo, W., Okello, E., Sebatta, E., Ssinabulya, I., Atukunda, E., Kitooleko, S., Semu, T., Salih, B.T., Komaranchath, A.M., Almahmeed, W.A.R., Gerges, F., Farook, F.S. Mohamed, Albakshy, F., Mahmood, N., Wani, S., Freudenberger, R., Islam, N., Quinones, J., Sundlof, D., Beitler, C., Centolanza, L., Cornell, K., Huffaker, S., Matos, L., Marzo, K., Paruchuri, V., Patel, D., Abdullaev, T., Alyavi, B., Mirzarakhimova, S., Tsoy, I., Bekbulatova, R., and Uzokov, J.
- Abstract
Aims: \ud Hypertensive disorders occur in women with peripartum cardiomyopathy (PPCM). How often hypertensive disorders co-exist, and to what extent they impact outcomes, is less clear. We describe differences in phenotype and outcomes in women with PPCM with and without hypertensive disorders during pregnancy.\ud \ud Methods: \ud The European Society of Cardiology PPCM Registry enrolled women with PPCM from 2012-2018. Three groups were examined: 1) women without hypertension (‘PPCM-noHTN’); 2) women with hypertension but without pre-eclampsia (‘PPCM-HTN’); 3) women with pre-eclampsia (‘PPCM-PE’). Maternal (6-month) and neonatal outcomes were compared.\ud \ud Results: \ud Of 735 women included, 452 (61.5%) had PPCM-noHTN, 99 (13.5%) had PPCM-HTN and 184 (25.0%) had PPCM-PE. Compared to women with PPCM-noHTN, women with PPCM-PE had more severe symptoms (NYHA IV in 44.4% and 29.9%, p
- Published
- 2021
32. POSA272 Using Real World Evidence to Characterise Utility in Patients with a Rare Disease: Analysis of Pompe Registry Data
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Malottki, K, primary, Wilson, K, additional, Fournier, M, additional, and Lawson, R, additional
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- 2022
- Full Text
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33. Long-Run Forecasting Surface and Ground Water Dynamics from Intermittent Observation Data: An Evaluation for 50 Years
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VU, Minh Tan, primary, Jardani, A., additional, Massei, N., additional, Deloffre, J., additional, Fournier, M., additional, and Laignel, B., additional
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- 2022
- Full Text
- View/download PDF
34. Results of Lisfranc’s Surgery in Athletic Patients
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Saxena, A., primary, Shou, L., additional, and Fournier, M., additional
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- 2021
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- View/download PDF
35. Connaissances et habitudes de prévention des patients atteints de xeroderma pigmentosum au Népal
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Fournier, M., Mishra, V., Parajuli, S., Grange, A., Paudel, U., and Grange, F.
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- 2023
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36. 166P Metabolomic prediction of breast cancer treatment toxicities
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Piffoux, M., Jacquemin, J., Petera, M., Boyault, S., Martin, A-L., Everhard, S., André, F., Pistilli, B., Fournier, M., Rouanet, P., Dhaini Merimeche, A., Sauterey, B., Campone, M., Tarpin, C., Mouret Reynier, M.A., Rigal, O., Petit, T., Pujos Guillot, E., Drouet, Y., and Tredan, O.
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- 2023
- Full Text
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37. Effectiveness of Selected Air Cleaning Devices During Dental Procedures
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Maurais, T, Kriese, J, Fournier, M, Langevin, L, MacLeod, B, Blier, S, Tessier-Guay, J P, Girardin, A, and Maheux, L
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- 2023
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38. L’infection par Omicron BA.1 des sujets préalablement vaccinés induit une modification à long terme du répertoire des lymphocytes B mémoires
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Sokal, A., Barba-Spaeth, G., Hunault, L., Fernandez, I., Broketa, M., Meola, A., Fourati, S., Azzaoui, I., Roeser, A., Crickx, E., Fournier, M., Michel, M., Godeau, B., Nguyen, Y., Reynaud, C.A., Weill, J.C., Rey, F., Bruhns, P., Chappert, P., and Mahevas, M.
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- 2023
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39. Neutropénies associées aux anticorps anti-cytoplasme des polynucléaires neutrophiles (ANCA)
- Author
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Fournier, M., Sicre De Fontbrune, F., Coppo, P., Fontenaille, C., Ebbo, M., Dion, J., Socié, G., Jardin, F., Moulinet, T., Martis, N., Arlet, J.B., and Terrier, B.
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- 2023
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40. Clinical Observation of Pricking Blood Therapy in Improving the SpO2 and Relieving Symptoms of Patients with COVID-19.
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Xinsheng Zhou, Li, Hongmei J., Yong Ping Chen, Fei Sun, Yong-Jian Lin, Lau, M. M., and Fournier, M.
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COVID-19 ,BLOOD sugar analysis ,OXYGEN saturation ,ADULT respiratory distress syndrome ,DRUG addiction - Abstract
This clinical observation evaluates the possible therapeutic effects of pricking blood on the patients with symptoms of delayed anaphylaxis induced by SARS-CoV-2. This procedure, known as the Angelica procedure, especially focuses on the possibility of replacing the need of ventilation for patients with shortness of breath. Los Angeles 116 confirmed (10 days before or 4 days after) COVID-19 patients were included in this study from early April 2020 to late May 2021. This procedure included pricking the skin on the forehead (Yintang Ex-HN3) and/or the tip of nose (Suliao GV25) with a lancet device made for blood sugar testing while drawing 300 to 400 μL (1--3 drops) of blood in the process. In phase I, a small sample of 39 patients with acute respiratory distress syndrome (ARDS) were chosen to receive the Angelica procedure. Phase II included a sample of 77 patients for the same procedure. The results indicated that the SpO2 of the patients increased from an average of 94.0 ± 1.0 to 96.6 ± 0.8%, a clinically and statistically significant difference (p < 0.001). The feelings of suffocation with pressure on the chest, headaches, body aches, and fatigue were relieved estimating around 4 minutes 48 s after the Angelica procedure (4 min 6 s, 5 min 56 s). Similar results were also achieved in phase II of the study; however, no therapeutic effects were seen in 2 patients who were in extremely critical condition. One of these died 6 days after the procedure. Symptom relapse occurred among 5 patients who re-experienced all the discomforts 2 to 3 days later after their chief complaints were initially relieved right after the procedure. Among these 5 patients, 4 suffered from severe underlying conditions, one being a 55 yr old male with an active narcotic addiction. The ARDS of these 5 patients went away in less than 1 h after receiving oxygen therapy in the hospital. Results herein suggest that the Angelica procedure can improve SpO
2 and relieve some symptoms in patients admitted to the clinic with mild to severe COVID-19 symptoms, however it may not be an alternative therapeutic option for patients in critical condition. [ABSTRACT FROM AUTHOR]- Published
- 2022
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- View/download PDF
41. Predisposal conditioning, treatment, and performance assessment of radioactive waste streams
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Holt Erika, Oksa Maria, Nieminen Matti, Abdelouas Abdesselam, Banford Anthony, Fournier Maxime, Mennecart Thierry, and Niederleithinger Ernst
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Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
Before the final disposal of radioactive wastes, various processes can be implemented to optimise the waste form. This can include different chemical and physical treatments, such as thermal treatment for waste reduction, waste conditioning for homogenisation and waste immobilisation for stabilisation prior to packaging and interim storage. Ensuring the durability and safety of the waste matrices and packages through performance and condition assessment is important for waste owners, waste management organisations, regulators and wider stakeholder communities. Technical achievements and lessons learned from the THERAMIN and PREDIS projects focused on low- and intermediate-level waste handling is shared here. The recently completed project on Thermal Treatment for Radioactive Waste Minimization and Hazard Reduction (THERAMIN) made advances in demonstrating the feasibility of different thermal treatment techniques to reduce volume and immobilise different streams of radioactive waste (LILW) prior to disposal. The Pre-Disposal Management of Radioactive Waste (PREDIS) project addresses innovations in the treatment of metallic materials, liquid organic waste and solid organic waste, which can result from nuclear power plant operation, decommissioning and other industrial processes. The project also addresses digitalisation solutions for improved safety and efficiency in handling and assessing cemented-waste packages in extended interim surface storage.
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- 2022
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42. Coupling a magnetic bottle multi-electron spectrometer with a liquid micro-jet device: a comprehensive study of solvated sodium benzoate at the O 1 s threshold
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Fournier Marine, Huart Lucie, Dupuy Rémi, Vacheresse Régis, Reinhardt Maximilian, Cubaynes Denis, Céolin Denis, Hervé du Penhoat Marie-Anne, Renault Jean-Philippe, Guigner Jean-Michel, Kumar Ajit, Lutet-Toti Bastien, Bozek John, Ismail Iyas, Journel Loïc, Lablanquie Pascal, Penent Francis, Nicolas Christophe, and Palaudoux Jérôme
- Subjects
Physics ,QC1-999 - Abstract
We have developed a magnetic bottle time-of-flight electron-electron coincidence spectrometer to perform measurements on solvated molecules in a liquid micro-jet. We present here the first results obtained after ionization of the oxygen 1s inner-shell of sodium benzoate molecules and show the possibilities to filter out the electron signal arising from the liquid phase from the signal of water molecules in the gas phase. Both photoelectrons and Auger electrons spectra (unfiltered and filtered) are presented.
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- 2022
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43. In-Can vitrification of ALPS slurries from Fukushima Daiichi effluent treatment using DEM&MELT technology
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Vernay Aliénor, Michel Caroline, Hollebecque Jean-François, Nonnet Hélène, Fournier Maxime, and Didierlaurent Régis
- Subjects
Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
After the accident at the Fukushima Dai-ichi Nuclear Power Station, a large amount of contaminated water was treated using several decontamination systems with different natures of adsorbents and chemicals. The resulting wastes, called Fukushima Effluent Treatment Wastes (FETW), were stored at the Fukushima Dai-ichi site. Vitrification could be the most promising treatment method to package these wastes. The consortium gathering CEA, Orano, ECM Technologies and ANDRA, implemented an in situ, robust, simple and versatile In-Can vitrification process, the DEM&MELT technology. Since 2018, the applicability of this technology for FETW treatment and conditioning has been evaluated. In 2021–2022, studies focused on one particular waste, coming from the ALPS system (Advanced Liquid Processing System-Multi Radionuclides Removal) generating around 70%vol. of FETW. This waste is composed of two co-precipitation slurries: one mainly composed of iron hydroxide, and one of calcium carbonate and magnesium hydroxide. The purpose of this article is to highlight the feasibility of ALPS slurries vitrification with DEM&MELT, relying on tests performed from laboratory-scale to full-scale. Macroscopically homogeneous glasses were produced using the DEM&MELT demonstrator, with a waste loading of 60 wt.% (expressed as waste dry mass) and microstructural analyses were performed. It gives promising results for FETW conditioning with the DEM&MELT process.
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- 2022
- Full Text
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44. The Thread.
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Adele, Leslie, Colette, Lynn, Tessa, Fournier, M., Kwip, and Bruce
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- *
LITERARY agents - Published
- 2023
45. Thromboembolic events in peripartum cardiomyopathy: results from the ESC EORP PPCM registry
- Author
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Tromp, Jasper, Jackson, Alice M, Abdelhamid, Magdy, Fouad, Doaa, Youssef, Ghada, Petrie, Mark C, Bauersachs, Johann, Sliwa, Karen, van der Meer, Peter, Gale, C P, Beleslin, B., Budaj, A., Chioncel, O., Dagres, N., Danchin, N., Emberson, J., Erlinge, D., Glikson, M., Gray, A., Kayikcioglu, M., Maggioni, A P, Nagy, V K, Nedoshivin, A., Petronio, A-S, Roos-Hesselink, J., Wallentin, L., Zeymer, U., Bauersachs, J., Sliwa, K., Boehm, M., Johnson, M., Hilfiker-Kleiner, D., Mbakwem, A., Mebazaa, A., Mouquet, F., Petrie, M., Pieske, B., Regitz-Zagrosek, V., Schaufelberger, M., Seferovic, P M, Tavazzi, L., van der Meer, P., Van Spaendonck-Zwarts, K., Favaloro, R., Favaloro, L., Carballo, M., Peradejordi, M., Renedo, M F, Absi, D., Bertolotti, A., Ratto, R., Talavera, M L, Gomez, R., Lockwood, S., Barton, T., Austin, M-A, Arstall, M., Aldridge, E., Chow, Y Y, Dekker, G., Mahadavan, G., Rose, J., Wittwer, M., Hoppe, U., Sandhofer, A., Bahshaliyev, A., Gasimov, Z., Babayev, A., Niftiyev, P., Hasanova, I., AlBannay, R., AlHaiki, W., Husain, A., Mahdi, N., Kurlianskaya, A., Lukyanchyk, M., Shatova, O., Troyanova-Shchutskaia, T., Anghel, L., De Pauw, M., Gevaert, S., De Backer, J., De Hosson, M., Vervaet, P., Timmermans, P J, Janssen, A., Yameogo, N V, Kagambega, L J, Cumyn, A., Caron, N., Cote, A-M, Sauve, N., Nkulu, D Ngoy, Lez, D Malamba, Yolola, E Ngoy, Krejci, J., Poloczkova, H., Ersboll, A., Gustafsson, F., Elrakshy, Y., Hassanein, M., Hammad, B., Eldin, O Nour, Fouad, D., Salman, S., Zareh, Z., Abdeall, D., Elenin, H Abo, Ebaid, H., El Nagar, A., Farag, S., Saed, M., El Rahman, Y H Abd, Ibrahim, B S, Abdelhamid, M., Hanna, R N W, Youssef, G., Awad, R., Botrous, O L I, Halawa, S Ibrahim, Nasr, G., Saad, A., El Tahlawi, M., Abdelbaset, M., El-Saadawy, M., El-Shorbagy, A., Shalaby, G., Anttonen, O., Tolppanen, H., Hamekoski, S., Menez, T., Noel, A., Lamblin, N., Coulon, C., de Groote, P., Langlois, S., Schurtz, G., Cohen-Solal, A., Fournier, M-C, Louadah, B., Akrout, N., Logeart, D., Leurent, G., Jovanova, S., Arnaudova-Dezulovicj, F., Livrinova, V., Berliner, D., Jungesblut, M., Koenig, T., Moulig, V A, Pfeffer, T J, Böhm, M., Kindermann, I., Schwarz, V., Schmitt, C., Swojanowsky, P., Pettit, S., McAdam, M., Patton, D., Bakhai, A., Krishnamurthy, V., Lim, L., Clifford, P., Bowers, N., Clark, A L, Witte, K., Cullington, D., Oliver, J., Simms, A., Mcginlay, M., McDonagh, T., Shah, A M, Amin-Youssef, G., De Courcey, J., Martin, K., Shaw, S., Vause, S., Wallace, S., Malin, G., Wick, C., Nikolaou, M., Rentoukas, I., Chinchilla, H., Andino, L., Iyengar, S., Chandra, S., Yadav, D K, Babu, R Ravi, Singh, A K, Kumar, S., Karunamay, B B, Chaubey, S K, Dhiman, S R, Jha, V C, Singh, S K, Kodati, D., Dasari, R., Sultana, S., Dewi, T I, Prameswari, H Sasmaya, Al-Farhan, H A, Al-Hussein, A., Yaseen, I F, Al-Azzawi, Falah, Al-Saedi, Ghazi, Mahmood, G M, Mohammed, M K, Ridha, A F, Shotan, A., Vazan, A., Goland, S., Biener, M., Senni, M., Grosu, A., Martin, E., Esposti, D Degli, Bacchelli, S., Borghi, C., Metra, M., Sciatti, E., Orabona, R., Sani, F., Brunetti, N D, Sinagra, G., Bobbo, M., D'Agata Mottolese, B., Gesuete, V., Rakar, S., Ramani, F., Kamiya, C., Barasa, A., Ngunga, M., Bajraktari, G., Hyseni, V., Lleshi, D., Pllana, E., Pllana, T., Noruzbaeva, A., Ismailov, F., Mirrakhimov, E., Abilova, S., Lunegova, O., Kerimkulova, A., Osmankulova, G., Duishenalieva, M., Kurmanbekova, B., Turgunov, M., Mamasaidova, S., Bektasheva, E., Kavoliūnienė, Aušra, Muckienė, Gintarė, Vaitiekienė, Audronė, Čelutkienė, Jelena, Balkevičienė, Laura, Barysienė, Jūratė, Chee, K H, Damasceno, A., Machava, M., van Veldhuisen, D J, van den Berg, M., van Hagen, I., Baris, L., Hurtado, P., Ezeonu, P., Isiguzo, G., Obeka, N., Onoh, R., Asogwa, F., Onyema, C., Otti, K., Ojji, D., Odili, A., Nwankwo, A., Karaye, K., Ishaq, N., Sanni, B., Abubakar, H., Mohammed, B., Sani, M., Kehinde, M., Afolabi, B., Amadi, C., Kilasho, M., Qamar, N., Furnaz, S., Gurmani, S., Kayani, M G A Mahmood, Munir, R., Hussain, S., Malik, S., Mumtaz, S., Saligan, J R, Rubis, P., Biernacka-Fijalkowska, B., Lesniak-Sobelga, A., Wisniowska-Smialek, S., Kasprzak, J D, Lelonek, M., Zycinski, P., Jankowski, L., Grajek, S., Oko-Sarnowska, Z., Rutkowska, A Bartczak, Kaluzna-Oleksy, M., Plaskota, K., Demkow, M., Dzielinska, Z., Henzel, J., Kryczka, K., Moiseeva, O., Irtyuga, O., Karelkina, E., Zazerskaya, I., Milinkovic, I., Živkovic, I., Ristic, A D, Milasinovic, D., Kong, W Kf, Tan, L K, Tan, J L, Thain, S., Poh, K K, Yip, J., Azibani, F., Hovelmann, J., Viljoen, C., Briton, O., Zamora, E., Orcajo, N Alonso, Carbonell, R., Pascual, C., Muncharaz, J Farre, Alonso-Pulpon, L., Cubero, J Segovia, Urquia, M Taibo, Garcia-Pavia, P., Gomez-Bueno, M., Cobo-Marcos, M., Briceno, A., Galvan, E De Teresa, Garcia-Pinilla, J M, Robles-Mezcua, A., Morcillo-Hildalgo, L., Elbushi, A., Suliman, A., Ahamed, N., Jazzar, K., Murtada, M., Goloskokova, V., Hullin, R., Yarol, N., Arrigo, M., Cavusoglu, Y., Eraslan, S., Fak, A S, Enar, S Catirli, Sarac, L., Cankurtaran, B., Gumrukcuoglu, H., Ozturk, F., Omagino, J., Mondo, C., Lwabi, P., Ingabire, P., Nabbaale, J., Nyakoojo, W., Okello, E., Sebatta, E., Ssinabulya, I., Atukunda, E., Kitooleko, S., Semu, T., Salih, B T, Komaranchath, A M, Almahmeed, W A R, Gerges, F., Farook, F S Mohamed, Albakshy, F., Mahmood, N., Wani, S., Freudenberger, R., Islam, N., Quinones, J., Sundlof, D., Beitler, C., Centolanza, L., Cornell, K., Huffaker, S., Matos, L., Marzo, K., Paruchuri, V., Patel, D., Abdullaev, T., Alyavi, B., Mirzarakhimova, S., Tsoy, I., Bekbulatova, R., and Uzokov, J.
- Published
- 2023
46. Study of the interaction between the influenza A virus polymerase and GTPase Rab11a
- Author
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Veler, H, Fan, H, Carrique, L, Keown, J, Sharps, J, Fournier, M, Fodor, E, and Grimes, J
- Subjects
Host-virus relationships ,Influenza A virus ,Virology ,Influenza - Abstract
The influenza A virus (IAV) genome that consists of eight viral RNA (vRNA) segments is transcribed and replicated by the viral heterotrimeric RNA-dependent RNA polymerase (RdRP) complex, composed of polymerase acidic (PA), polymerase basic 1 (PB1), and PB2, subunits, in the cell nucleus. Replicated vRNA segments are assembled with RdRP and oligomeric nucleoprotein into viral ribonucleoprotein (vRNP) complexes which are exported from the nucleus and transported across the cytoplasm to be packed into progeny virions. The GTPase Rab11a associated with recycling endosomes is believed to contribute to this process by mediating the cytoplasmic transport of vRNPs. However, how vRNPs interact with Rab11a remains poorly understood. In this D.Phil. project, I have utilised a combination of biochemical and structural approaches to characterise the interaction between the IAV RdRP and Rab11a. Initially, using a GST pull-down assay, I showed that the interaction between the IAV RdRP and Rab11a is direct, and that the 627- domain of PB2 is required for this interaction. Furthermore, my study demonstrated for the first time that Rab11a has a differential specificity for vRNP but not cRNP. Analysis of the Rab11a interactome further revealed that IAV infection reduces Rab11a binding to Rab11-family interacting partners (Rab11-FIPs), thereby altering the stoichiometry of cytoplasmic motor proteins bound by Rab11a. Using mutant Rab11a in a GST pull-down assay, this study provides the first evidence that IAV RdRP binds to the same site on Rab11a as Rab11-FIPs. It was also investigated here whether Rab11a has a role in determining the host specificity of influenza viruses. However, this study could not identify any adaptive mutations in PB2 that may affect the interaction between RdRP and Rab11a. Moreover, the study also did not identify the exact site of Rab11a binding on the viral RdRP using cryo- electron microscopy. However, performing a small-angle X-ray scattering analysis I showed that C-terminal two thirds of PB2 (PB2-C) and Rab11a form a well-folded protein complex in solution, and confirmed in a controlled pull-down assay that the interaction between PB2-C and Rab11a is direct. Finally, I have also established a workflow to study the interaction between IAV vRNPs and Rab11a in the context of live infected cells using full field cryo-X-ray microscopy. The findings of my D.Phil. work expand our understanding of the cytoplasmic transport of the influenza virus vRNPs. Identifying the exact site of Rab11a binding on the viral RdRP could uncover a novel target site for the development of an influenza antiviral drug.
- Published
- 2021
47. Sensitivity of groundwater levels to low-frequency climate variability in a large watershed.
- Author
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Baulon L, Fossa M, Massei N, Flipo N, Gallois N, Fournier M, Dieppois B, Danaila L, Allier D, and Bessiere H
- Abstract
Groundwater level (GWL) can vary over a wide range of timescales. Previous studies highlighted that low-frequency variability (interannual (2-8 years) to decadal (>10 years)) originating from large-scale climate variability, represents a significant part of GWL variance. It remains an open question, however, how GWL, including extremes, may respond to changes in large-scale climate forcing, affecting precipitation variability. Focusing on the Seine River basin, this study therefore aims to assess how GWLs respond to changes in interannual to decadal climate variability. We implemented an empirical numerical approach, which enables an assessment of the GWL sensitivity to changes in precipitation variability over a range of timescales (up to decadal), using the Seine hydrosystem as a case study. The approach consists in: i) identifying and modifying the spectral content of precipitation in the low-frequency range; ii) using these perturbed precipitation fields as input in the physically-based hydrological/hydrogeological CaWaQS model for the Seine River basin to simulate the corresponding GWL response; iii) comparing the spectral content, mean, variance and extremes of perturbed GWLs with reference (i.e. unperturbed) GWLs. Two interannual (2-4 yr and 5-8 yr) and one decadal (15 yr) timescales were modified individually by either increasing or decreasing their amplitude by 50 %. This led to six scenarios of perturbed low-frequency precipitation variability, which were subsequently used as CaWaQS inputs to assess the GWL response. Results indicated increased (decreased) GWL up to 5 m when low-frequency precipitation variability increased (decreased) by 50 %. This led to an increased occurrence of groundwater floods (droughts) with increased severity and decreased occurrence of groundwater droughts (floods) with decreased severity, respectively. These results indicate: i) how using biased climate data, in terms of low-frequency variability, leads to large deviations in the GWL simulation, ii) to what extent potential changes in low-frequency climate variability may affect future GWL, and particularly drought and flood occurrence and severity., (Copyright © 2024. Published by Elsevier B.V.)
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- 2024
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48. Congenital myasthenic syndromes in adults: clinical features, diagnosis and long-term prognosis.
- Author
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Theuriet J, Masingue M, Behin A, Ferreiro A, Bassez G, Jaubert P, Tarabay O, Fer F, Pegat A, Bouhour F, Svahn J, Petiot P, Jomir L, Chauplannaz G, Cornut-Chauvinc C, Manel V, Salort-Campana E, Attarian S, Fortanier E, Verschueren A, Kouton L, Camdessanché JP, Tard C, Magot A, Péréon Y, Noury JB, Minot-Myhie MC, Perie M, Taithe F, Farhat Y, Millet AL, Cintas P, Solé G, Spinazzi M, Esselin F, Renard D, Sacconi S, Ezaru A, Malfatti E, Mallaret M, Magy L, Diab E, Merle P, Michaud M, Fournier M, Pakleza AN, Chanson JB, Lefeuvre C, Laforet P, Richard P, Sternberg D, Villar-Quiles RN, Stojkovic T, and Eymard B
- Subjects
- Humans, Female, Male, Adult, Prognosis, Middle Aged, Retrospective Studies, Young Adult, France epidemiology, Adolescent, Muscle Proteins genetics, Aged, Follow-Up Studies, Myasthenic Syndromes, Congenital genetics, Myasthenic Syndromes, Congenital diagnosis, Myasthenic Syndromes, Congenital physiopathology
- Abstract
Congenital myasthenic syndromes (CMS) are clinically and genetically heterogeneous diseases caused by mutations affecting neuromuscular transmission. Even if the first symptoms mainly occur during childhood, adult neurologists must confront this challenging diagnosis and manage these patients throughout their adulthood. However, long-term follow-up data from large cohorts of CMS patients are lacking, and the long-term prognosis of these patients is largely unknown. We report the clinical features, diagnostic difficulties, and long-term prognosis of a French nationwide cohort of 235 adult patients with genetically confirmed CMS followed in 23 specialized neuromuscular centres. Data were retrospectively analysed. Of the 235 patients, 123 were female (52.3%). The diagnosis was made in adulthood in 139 patients, 110 of whom presented their first symptoms before the age of 18. Mean follow-up time between first symptoms and last visit was 34 years [standard deviation (SD) = 15.1]. Pathogenic variants were found in 19 disease-related genes. CHRNE-low expressor variants were the most common (23.8%), followed by variants in DOK7 (18.7%) and RAPSN (14%). Genotypes were clustered into four groups according to the initial presentation: ocular group (CHRNE-LE, CHRND, FCCMS), distal group (SCCMS), limb-girdle group (RAPSN, COLQ, DOK7, GMPPB, GFPT1), and a variable-phenotype group (MUSK, AGRN). The phenotypical features of CMS did not change throughout life. Only four genotypes had a proportion of patients requiring intensive care unit admission that exceeded 20%: RAPSN (54.8%), MUSK (50%), DOK7 (38.6%) and AGRN (25.0%). In RAPSN and MUSK patients most ICU admissions occurred before age 18 years and in DOK7 and AGRN patients at or after 18 years of age. Different patterns of disease course (stability, improvement and progressive worsening) may succeed one another in the same patient throughout life, particularly in AGRN, DOK7 and COLQ. At the last visit, 55% of SCCMS and 36.3% of DOK7 patients required ventilation; 36.3% of DOK7 patients, 25% of GMPPB patients and 20% of GFPT1 patients were wheelchair-bound; most of the patients who were both wheelchair-bound and ventilated were DOK7 patients. Six patients died in this cohort. The positive impact of therapy was striking, even in severely affected patients. In conclusion, even if motor and/or respiratory deterioration could occur in patients with initially moderate disease, particularly in DOK7, SCCMS and GFPT1 patients, the long-term prognosis for most CMS patients was favourable, with neither ventilation nor wheelchair needed at last visit. CHRNE-LE patients did not worsen during adulthood and RAPSN patients, often severely affected in early childhood, subsequently improved., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.)
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- 2024
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49. Precautions to Consider in the Analysis of Prognostic and Predictive Indices.
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Chartier L, Belot A, Chaillol I, Elsensohn MH, Portugues C, Fournier M, Joubert C, Gat E, Pizot C, Fogarty P, Murairi T, Ammar RO, Paget J, Cherblanc F, Ricci R, Vercellino L, Kanoun S, Cottereau AS, Thieblemont C, and Casasnovas O
- Subjects
- Humans, Statistics as Topic, Prognosis
- Abstract
Understanding the differences between prognostic and predictive indices is imperative for medical research advances. We have developed a new prognostic measure that will identify the strengths, limitations, and potential applications in clinical practice., (© 2024 by the Society of Nuclear Medicine and Molecular Imaging.)
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- 2024
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50. Assessment of health state utilities associated with adult and pediatric acid sphingomyelinase deficiency (ASMD).
- Author
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Matza LS, Stewart KD, Fournier M, Rowen D, Lachmann R, Scarpa M, Mengel E, Obermeyer T, Ayik E, Laredo F, and Pulikottil-Jacob R
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- Humans, Male, Female, Adult, Child, Quality of Life, Middle Aged, Severity of Illness Index, Quality-Adjusted Life Years, Adolescent, United Kingdom, Child, Preschool, Interviews as Topic, Cost-Benefit Analysis, Niemann-Pick Disease, Type B, Health Status
- Abstract
Introduction: Acid sphingomyelinase deficiency (ASMD) type B is a rare genetic disorder leading to enlargement of the spleen and liver, pulmonary dysfunction, and other symptoms. Cost-utility analyses are often conducted to quantify the value of new treatments, and these analyses require health state utilities. Therefore, the purpose of this study was to estimate utilities associated with varying levels of severity of adult and pediatric ASMD type B., Methods: Seven adult and seven child health state vignettes describing ASMD were developed based on published literature, clinical trial results, and interviews with clinicians, patients with ASMD, and parents of children with ASMD. The health states were valued in time trade-off interviews with adult general population respondents in the UK., Results: Interviews were completed with 202 participants (50.0% female; mean age = 41.3 years). The health state representing ASMD without impairment had the highest mean utility for both the adult and child health states (0.92/0.94), and severe ASMD had the lowest mean utility (0.33/0.45). Every child health state had a significantly greater utility than the corresponding adult health state. Differences between adult/child paired states ranged from 0.02 to 0.13. Subgroup analyses explored the impact of parenting status on valuation of child health states., Discussion: Greater severity of ASMD was associated with lower mean utility. Results have implications for valuation of pediatric health states. The resulting utilities may be useful in cost-utility modeling estimating the value of treatment for ASMD., (© 2024. The Author(s).)
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- 2024
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