48 results on '"Ferreira, Vanessa M."'
Search Results
2. Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 controlled human infection study
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Alparaque, Maricel, Anid, Liisa, Barnes, Eleanor, Benamore, Rachel, Bharti, Neha, Patel, Bhumika, Burns, Adrian, Byard, Nicholas, Conway, Oliver, Cooper, Cushla, Crowther, Charlotte, Dunachie, Susanna J, Johnstone, Trudi, Jose, Jyolsna, Luciw, Michael, Mujadidi, Yama, Nehiweze, Aiseosa, Nyamunda, Sibongile, Orobiyi-Rieba, Maria, Parvelikudy, Bindu, Platt, Abigail, Pswarayi, Dzikamayi, Quaddy, Jack, Samuel, Binnie Elizabeth, Sette, Alessandro, Sodipo, Victoria, Srijith, Preethu, Stone, Helen, Turner, Cheryl, Valmores, Mary Ann, Voaides, Alexandru, Vuddamalay, Gavindren, Jackson, Susan, Marshall, Julia L, Mawer, Andrew, Lopez-Ramon, Raquel, Harris, Stephanie A, Satti, Iman, Hughes, Eileen, Preston-Jones, Hannah, Cabrera Puig, Ingrid, Longet, Stephanie, Tipton, Tom, Laidlaw, Stephen, Doherty, Rebecca Powell, Morrison, Hazel, Mitchell, Robert, Tanner, Rachel, Ateere, Alberta, Stylianou, Elena, Wu, Meng-San, Fredsgaard-Jones, Timothy P W, Breuer, Judith, Rapeport, Garth, Ferreira, Vanessa M, Gleeson, Fergus, Pollard, Andrew J, Carroll, Miles, Catchpole, Andrew, Chiu, Christopher, and McShane, Helen
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- 2024
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3. Worldwide variation in cardiovascular magnetic resonance practice models
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Sierra-Galan, Lilia M., Estrada-Lopez, Edgar E. S., Ferrari, Victor A., Raman, Subha V., Ferreira, Vanessa M., Raj, Vimaj, Joseph, Elizabeth, Schulz-Menger, Jeanette, Chan, Carmen W. S., Chen, Sylvia S. M., Cheng, Yuchen, De Lara Fernandez, Juliano, Terashima, Masahiro, and Albert, Timothy S. E.
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- 2023
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4. Cardiovascular magnetic resonance for evaluation of cardiac involvement in COVID-19: recommendations by the Society for Cardiovascular Magnetic Resonance
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Ferreira, Vanessa M., Plein, Sven, Wong, Timothy C., Tao, Qian, Raisi-Estabragh, Zahra, Jain, Supriya S., Han, Yuchi, Ojha, Vineeta, Bluemke, David A., Hanneman, Kate, Weinsaft, Jonathan, Vidula, Mahesh K., Ntusi, Ntobeko A. B., Schulz-Menger, Jeanette, and Kim, Jiwon
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- 2023
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5. Editorial Expression of Concern: Splenic T1-mapping: a novel quantitative method for assessing adenosine stress adequacy for cardiovascular magnetic resonance
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Liu, Alexander, Wijesurendra, Rohan S., Ariga, Rina, Mahmod, Masliza, Levelt, Eylem, Greiser, Andreas, Petrou, Mario, Krasopoulos, George, Forfar, John C., Kharbanda, Rajesh K., Channon, Keith M., Neubauer, Stefan, Piechnik, Stefan K., and Ferreira, Vanessa M.
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- 2023
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6. The Society for Cardiovascular Magnetic Resonance Registry at 150,000
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Tong, Matthew S., Slivnick, Jeremy A., Sharif, Behzad, Kim, Han W., Young, Alistair A., Sierra-Galan, Lilia M., Mukai, Kanae, Farzaneh-Far, Afshin, Al-Kindi, Sadeer, Chan, Angel T., Dibu, George, Elliott, Michael D., Ferreira, Vanessa M., Grizzard, John, Kelle, Sebastian, Lee, Simon, Malahfji, Maan, Petersen, Steffen E., Polsani, Venkateshwar, Toro-Salazar, Olga H., Shaikh, Kamran A., Shenoy, Chetan, Srichai, Monvadi B., Stojanovska, Jadranka, Tao, Qian, Wei, Janet, Weinsaft, Jonathan W., Wince, W. Benjamin, Chudgar, Priya D., Judd, Matthew, Judd, Robert M., Shah, Dipan J., and Simonetti, Orlando P.
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- 2024
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7. Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
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Raman, Betty, McCracken, Celeste, Cassar, Mark P, Moss, Alastair J, Finnigan, Lucy, Samat, Azlan Helmy A, Ogbole, Godwin, Tunnicliffe, Elizabeth M, Alfaro-Almagro, Fidel, Menke, Ricarda, Xie, Cheng, Gleeson, Fergus, Lukaschuk, Elena, Lamlum, Hanan, McGlynn, Kevin, Popescu, Iulia A, Sanders, Zeena-Britt, Saunders, Laura C, Piechnik, Stefan K, Ferreira, Vanessa M, Nikolaidou, Chrysovalantou, Rahman, Najib M, Ho, Ling-Pei, Harris, Victoria C, Shikotra, Aarti, Singapuri, Amisha, Pfeffer, Paul, Manisty, Charlotte, Kon, Onn M, Beggs, Mark, O'Regan, Declan P, Fuld, Jonathan, Weir-McCall, Jonathan R, Parekh, Dhruv, Steeds, Rick, Poinasamy, Krisnah, Cuthbertson, Dan J, Kemp, Graham J, Semple, Malcolm G, Horsley, Alexander, Miller, Christopher A, O'Brien, Caitlin, Shah, Ajay M, Chiribiri, Amedeo, Leavy, Olivia C, Richardson, Matthew, Elneima, Omer, McAuley, Hamish J C, Sereno, Marco, Saunders, Ruth M, Houchen-Wolloff, Linzy, Greening, Neil J, Bolton, Charlotte E, Brown, Jeremy S, Choudhury, Gourab, Diar Bakerly, Nawar, Easom, Nicholas, Echevarria, Carlos, Marks, Michael, Hurst, John R, Jones, Mark G, Wootton, Daniel G, Chalder, Trudie, Davies, Melanie J, De Soyza, Anthony, Geddes, John R, Greenhalf, William, Howard, Luke S, Jacob, Joseph, Man, William D-C, Openshaw, Peter J M, Porter, Joanna C, Rowland, Matthew J, Scott, Janet T, Singh, Sally J, Thomas, David C, Toshner, Mark, Lewis, Keir E, Heaney, Liam G, Harrison, Ewen M, Kerr, Steven, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Sheikh, Aziz, Zheng, Bang, Jenkins, R Gisli, Cox, Eleanor, Francis, Susan, Halling-Brown, Mark, Chalmers, James D, Greenwood, John P, Plein, Sven, Hughes, Paul J C, Thompson, A A Roger, Rowland-Jones, Sarah L, Wild, James M, Kelly, Matthew, Treibel, Thomas A, Bandula, Steven, Aul, Raminder, Miller, Karla, Jezzard, Peter, Smith, Stephen, Nichols, Thomas E, McCann, Gerry P, Evans, Rachael A, Wain, Louise V, Brightling, Christopher E, Neubauer, Stefan, Baillie, J K, Shaw, Alison, Hairsine, Brigid, Kurasz, Claire, Henson, Helen, Armstrong, Lisa, Shenton, Liz, Dobson, H, Dell, Amanda, Lucey, Alice, Price, Andrea, Storrie, Andrew, Pennington, Chris, Price, Claire, Mallison, Georgia, Willis, Gemma, Nassa, Heeah, Haworth, Jill, Hoare, Michaela, Hawkings, Nancy, Fairbairn, Sara, Young, Susan, Walker, S, Jarrold, I, Sanderson, Amy, David, C, Chong-James, K, Zongo, O, James, W Y, Martineau, A, King, Bernie, Armour, C, McAulay, D, Major, E, McGinness, Jade, McGarvey, L, Magee, N, Stone, Roisin, Drain, S, Craig, T, Bolger, A, Haggar, Ahmed, Lloyd, Arwel, Subbe, Christian, Menzies, Daniel, Southern, David, McIvor, Emma, Roberts, K, Manley, R, Whitehead, Victoria, Saxon, W, Bularga, A, Mills, N L, El-Taweel, Hosni, Dawson, Joy, Robinson, Leanne, Saralaya, Dinesh, Regan, Karen, Storton, Kim, Brear, Lucy, Amoils, S, Bermperi, Areti, Elmer, Anne, Ribeiro, Carla, Cruz, Isabel, Taylor, Jessica, Worsley, J, Dempsey, K, Watson, L, Jose, Sherly, Marciniak, S, Parkes, M, McQueen, Alison, Oliver, Catherine, Williams, Jenny, Paradowski, Kerry, Broad, Lauren, Knibbs, Lucy, Haynes, Matthew, Sabit, Ramsey, Milligan, L, Sampson, Claire, Hancock, Alyson, Evenden, Cerys, Lynch, Ceri, Hancock, Kia, Roche, Lisa, Rees, Meryl, Stroud, Natalie, Thomas-Woods, T, Heller, S, Robertson, E, Young, B, Wassall, Helen, Babores, M, Holland, Maureen, Keenan, Natalie, Shashaa, Sharlene, Price, Carly, Beranova, Eva, Ramos, Hazel, Weston, Heather, Deery, Joanne, Austin, Liam, Solly, Reanne, Turney, Sharon, Cosier, Tracey, Hazelton, Tracy, Ralser, M, Wilson, Ann, Pearce, Lorraine, Pugmire, S, Stoker, Wendy, McCormick, W, Dewar, A, Arbane, Gill, Kaltsakas, G, Kerslake, Helen, Rossdale, J, Bisnauthsing, Karen, Aguilar Jimenez, Laura A, Martinez, L M, Ostermann, Marlies, Magtoto, Murphy M, Hart, Nicholas, Marino, Philip, Betts, Sarah, Solano, Teresa S, Arias, Ava Maria, Prabhu, A, Reed, Annabel, Wrey Brown, Caroline, Griffin, Denise, Bevan, Emily, Martin, Jane, Owen, J, Alvarez Corral, Maria, Williams, Nick, Payne, Sheila, Storrar, Will, Layton, Alison, Lawson, Cathy, Mills, Clare, Featherstone, James, Stephenson, Lorraine, Burdett, Tracy, Ellis, Y, Richards, A, Wright, C, Sykes, D L, Brindle, K, Drury, Katie, Holdsworth, L, Crooks, M G, Atkin, Paul, Flockton, Rachel, Thackray-Nocera, Susannah, Mohamed, Abdelrahman, Taylor, Abigail, Perkins, Emma, Ross, Gavin, McGuinness, Heather, Tench, Helen, Phipps, Janet, Loosley, Ronda, Wolf-Roberts, Rebecca, Coetzee, S, Omar, Zohra, Ross, Alexandra, Card, Bethany, Carr, Caitlin, King, Clara, Wood, Chloe, Copeland, D, Calvelo, Ellen, Chilvers, Edwin R, Russell, Emily, Gordon, Hussain, Nunag, Jose Lloyd, Schronce, J, March, Katherine, Samuel, Katherine, Burden, L, Evison, Lynsey, McLeavey, Laura, Orriss-Dib, Lorna, Tarusan, Lawrence, Mariveles, Myril, Roy, Maura, Mohamed, Noura, Simpson, Neil, Yasmin, Najira, Cullinan, P, Daly, Patrick, Haq, Sulaimaan, Moriera, Silvia, Fayzan, Tamanah, Munawar, Unber, Nwanguma, Uchechi, Lingford-Hughes, A, Altmann, Danny, Johnston, D, Mitchell, J, Valabhji, J, Price, L, Molyneaux, P L, Thwaites, Ryan S, Walsh, S, Frankel, A, Lightstone, L, Wilkins, M, Willicombe, M, McAdoo, S, Touyz, R, Guerdette, Anne-Marie, Warwick, Katie, Hewitt, Melanie, Reddy, R, White, Sonia, McMahon, A, Hoare, Amy, Knighton, Abigail, Ramos, Albert, Te, Amelie, Jolley, Caroline J, Speranza, Fabio, Assefa-Kebede, Hosanna, Peralta, Ida, Breeze, Jonathon, Shevket, K, Powell, Natassia, Adeyemi, Oluwaseun, Dulawan, Pearl, Adrego, Rita, Byrne, S, Patale, Sheetal, Hayday, A, Malim, M, Pariante, C, Sharpe, C, Whitney, J, Bramham, K, Ismail, K, Wessely, S, Nicholson, T, Ashworth, Andrew, Humphries, Amy, Tan, Ai Lyn, Whittam, Beverley, Coupland, C, Favager, Clair, Peckham, D, Wade, Elaine, Saalmink, Gwen, Clarke, Jude, Glossop, Jodie, Murira, Jennifer, Rangeley, Jade, Woods, Janet, Hall, Lucy, Dalton, Matthhew, Window, Nicola, Beirne, Paul, Hardy, Tim, Coakley, G, Turtle, Lance, Berridge, Anthony, Cross, Andy, Key, Angela L, Rowe, Anna, Allt, Ann Marie, Mears, Chloe, Malein, Flora, Madzamba, Gladys, Hardwick, H E, Earley, Joanne, Hawkes, Jenny, Pratt, James, Wyles, J, Tripp, K A, Hainey, Kera, Allerton, Lisa, Lavelle-Langham, L, Melling, Lucy, Wajero, Lilian O, Poll, L, Noonan, Matthew J, French, N, Lewis-Burke, N, Williams-Howard, S A, Cooper, Shirley, Kaprowska, Sabina, Dobson, S L, Marsh, Sophie, Highett, Victoria, Shaw, V, Beadsworth, M, Defres, S, Watson, Ekaterina, Tiongson, Gerlynn F, Papineni, Padmasayee, Gurram, Sambasivarao, Diwanji, Shalin N, Quaid, Sheena, Briggs, A, Hastie, Claire, Rogers, Natalie, Stensel, D, Bishop, L, McIvor, K, Rivera-Ortega, P, Al-Sheklly, B, Avram, Cristina, Faluyi, David, Blaikely, J, Piper Hanley, K, Radhakrishnan, K, Buch, M, Hanley, N A, Odell, Natasha, Osbourne, Rebecca, Stockdale, Sue, Felton, T, Gorsuch, T, Hussell, T, Kausar, Zunaira, Kabir, T, McAllister-Williams, H, Paddick, S, Burn, D, Ayoub, A, Greenhalgh, Alan, Sayer, A, Young, A, Price, D, Burns, G, MacGowan, G, Fisher, Helen, Tedd, H, Simpson, J, Jiwa, Kasim, Witham, M, Hogarth, Philip, West, Sophie, Wright, S, McMahon, Michael J, Neill, Paula, Dougherty, Andrew, Morrow, A, Anderson, David, Grieve, D, Bayes, Hannah, Fallon, K, Mangion, K, Gilmour, L, Basu, N, Sykes, R, Berry, C, McInnes, I B, Donaldson, A, Sage, E K, Barrett, Fiona, Welsh, B, Bell, Murdina, Quigley, Jackie, Leitch, Karen, Macliver, L, Patel, Manish, Hamil, R, Deans, Andrew, Furniss, J, Clohisey, S, Elliott, Anne, Solstice, A R, Deas, C, Tee, Caroline, Connell, David, Sutherland, Debbie, George, J, Mohammed, S, Bunker, Jenny, Holmes, Katie, Dipper, A, Morley, Anna, Arnold, David, Adamali, H, Welch, H, Morrison, Leigh, Stadon, Louise, Maskell, Nick, Barratt, Shaney, Dunn, Sarah, Waterson, Samuel, Jayaraman, Bhagy, Light, Tessa, Selby, N, Hosseini, A, Shaw, Karen, Almeida, Paula, Needham, Robert, Thomas, Andrew K, Matthews, Laura, Gupta, Ayushman, Nikolaidis, Athanasios, Dupont, Catherine, Bonnington, J, Chrystal, Melanie, Greenhaff, P L, Linford, S, Prosper, Sabrina, Jang, W, Alamoudi, Asma, Bloss, Angela, Megson, Clare, Nicoll, Debby, Fraser, Emily, Pacpaco, Edmund, Conneh, Florence, Ogg, G, McShane, H, Koychev, Ivan, Chen, Jin, Pimm, John, Ainsworth, Mark, Pavlides, M, Sharpe, M, Havinden-Williams, May, Petousi, Nayia, Talbot, Nick, Carter, Penny, Kurupati, Prathiba, Dong, T, Peng, Yanchun, Burns, A, Kanellakis, N, Korszun, A, Connolly, B, Busby, J, Peto, T, Patel, B, Nolan, C M, Cristiano, Daniele, Walsh, J A, Liyanage, Kamal, Gummadi, Mahitha, Dormand, N, Polgar, Oliver, George, P, Barker, R E, Patel, Suhani, Gibbons, M, Matila, Darwin, Jarvis, Hannah, Lim, Lai, Olaosebikan, Olaoluwa, Ahmad, Shanaz, Brill, Simon, Mandal, S, Laing, C, Michael, Alice, Reddy, A, Johnson, C, Baxendale, H, Parfrey, H, Mackie, J, Newman, J, Pack, Jamie, Parmar, J, Paques, K, Garner, Lucie, Harvey, Alice, Summersgill, C, Holgate, D, Hardy, E, Oxton, J, Pendlebury, Jessica, McMorrow, L, Mairs, N, Majeed, N, Dark, P, Ugwuoke, R, Knight, Sean, Whittaker, S, Strong-Sheldrake, Sophia, Matimba-Mupaya, Wadzanai, Chowienczyk, P, Pattenadk, Dibya, Hurditch, E, Chan, Flora, Carborn, H, Foot, H, Bagshaw, J, Hockridge, J, Sidebottom, J, Lee, Ju Hee, Birchall, K, Turner, Kim, Haslam, L, Holt, L, Milner, L, Begum, M, Marshall, M, Steele, N, Tinker, N, Ravencroft, Phillip, Butcher, Robyn, Misra, S, Coburn, Zach, Fairman, Alexandra, Ford, Amber, Holbourn, Ailsa, Howell, Alice, Lawrie, Allan, Lye, Alison, Mbuyisa, Angeline, Zawia, Amira, Holroyd-Hind, B, Thamu, B, Clark, Cameron, Jarman, Claire, Norman, C, Roddis, C, Foote, David, Lee, Elvina, Ilyas, F, Stephens, G, Newell, Helen, Turton, Helena, Macharia, Irene, Wilson, Imogen, Cole, Joby, McNeill, J, Meiring, J, Rodger, J, Watson, James, Chapman, Kerry, Harrington, Kate, Chetham, Luke, Hesselden, L, Nwafor, Lorenza, Dixon, Myles, Plowright, Megan, Wade, Phillip, Gregory, Rebecca, Lenagh, Rebecca, Stimpson, R, Megson, Sharon, Newman, Tom, Cheng, Yutung, Goodwin, Camelia, Heeley, Cheryl, Sissons, D, Sowter, D, Gregory, Heidi, Wynter, Inez, Hutchinson, John, Kirk, Jill, Bennett, Kaytie, Slack, Katie, Allsop, Lynne, Holloway, Leah, Flynn, Margaret, Gill, Mandy, Greatorex, M, Holmes, Megan, Buckley, Phil, Shelton, Sarah, Turner, Sarah, Sewell, Terri Ann, Whitworth, V, Lovegrove, Wayne, Tomlinson, Johanne, Warburton, Louise, Painter, Sharon, Vickers, Carinna, Redwood, Dawn, Tilley, Jo, Palmer, Sue, Wainwright, Tania, Breen, G, Hotopf, M, Dunleavy, A, Teixeira, J, Ali, Mariam, Mencias, Mark, Msimanga, N, Siddique, Sulman, Samakomva, T, Tavoukjian, Vera, Forton, D, Ahmed, R, Cook, Amanda, Thaivalappil, Favas, Connor, Lynda, Rees, Tabitha, McNarry, M, Williams, N, McCormick, Jacqueline, McIntosh, Jerome, Vere, Joanne, Coulding, Martina, Kilroy, Susan, Turner, Victoria, Butt, Al-Tahoor, Savill, Heather, Fraile, Eva, Ugoji, Jacinta, Landers, G, Lota, Harpreet, Portukhay, Sofiya, Nasseri, Mariam, Daniels, Alison, Hormis, Anil, Ingham, Julie, Zeidan, Lisa, Osborne, Lynn, Chablani, Manish, Banerjee, A, David, A, Pakzad, A, Rangelov, B, Williams, B, Denneny, E, Willoughby, J, Xu, M, Mehta, P, Batterham, R, Bell, R, Aslani, S, Lilaonitkul, W, Checkley, A, Bang, Dongchun, Basire, Donna, Lomas, D, Wall, E, Plant, Hannah, Roy, K, Heightman, M, Lipman, M, Merida Morillas, Marta, Ahwireng, Nyarko, Chambers, R C, Jastrub, Roman, Logan, S, Hillman, T, Botkai, A, Casey, A, Neal, A, Newton-Cox, A, Cooper, B, Atkin, C, McGee, C, Welch, C, Wilson, D, Sapey, E, Qureshi, H, Hazeldine, J, Lord, J M, Nyaboko, J, Short, J, Stockley, J, Dasgin, J, Draxlbauer, K, Isaacs, K, Mcgee, K, Yip, K P, Ratcliffe, L, Bates, M, Ventura, M, Ahmad Haider, N, Gautam, N, Baggott, R, Holden, S, Madathil, S, Walder, S, Yasmin, S, Hiwot, T, Jackson, T, Soulsby, T, Kamwa, V, Peterkin, Z, Suleiman, Z, Chaudhuri, N, Wheeler, H, Djukanovic, R, Samuel, R, Sass, T, Wallis, T, Marshall, B, Childs, C, Marouzet, E, Harvey, M, Fletcher, S, Dickens, C, Beckett, P, Nanda, U, Daynes, E, Charalambou, A, Yousuf, A J, Lea, A, Prickett, A, Gooptu, Bibek, Hargadon, Beverley, Bourne, Charlotte, Christie, C, Edwardson, C, Lee, D, Baldry, E, Stringer, E, Woodhead, F, Mills, G, Arnold, H, Aung, H, Qureshi, I N, Finch, J, Skeemer, J, Hadley, K, Khunti, Kamlesh, Carr, Liesel, Ingram, L, Aljaroof, M, Bakali, M, Bakau, M, Baldwin, M, Bourne, Michelle, Pareek, Manish, Soares, M, Tobin, Martin, Armstrong, Natalie, Brunskill, Nigel, Goodman, N, Cairns, P, Haldar, Pranab, McCourt, P, Dowling, R, Russell, Richard, Diver, Sarah, Edwards, Sarah, Glover, Sarah, Parker, S, Siddiqui, Salman, Ward, T J C, Mcnally, T, Thornton, T, Yates, Tom, Ibrahim, W, Monteiro, Will, Thickett, D, Wilkinson, D, Broome, M, McArdle, P, Upthegrove, R, Wraith, D, Langenberg, C, Summers, C, Bullmore, E, Heeney, J L, Schwaeble, W, Sudlow, C L, Adeloye, D, Newby, D E, Rudan, I, Shankar-Hari, M, Thorpe, M, Pius, R, Walmsley, S, McGovern, A, Ballard, C, Allan, L, Dennis, J, Cavanagh, J, Petrie, J, O'Donnell, K, Spears, M, Sattar, N, MacDonald, S, Guthrie, E, Henderson, M, Guillen Guio, Beatriz, Zhao, Bang, Lawson, C, Overton, Charlotte, Taylor, Chris, Tong, C, Mukaetova-Ladinska, Elizabeta, Turner, E, Pearl, John E, Sargant, J, Wormleighton, J, Bingham, Michelle, Sharma, M, Steiner, Mike, Samani, Nilesh, Novotny, Petr, Free, Rob, Allen, R J, Finney, Selina, Terry, Sarah, Brugha, Terry, Plekhanova, Tatiana, McArdle, A, Vinson, B, Spencer, L G, Reynolds, W, Ashworth, M, Deakin, B, Chinoy, H, Abel, K, Harvie, M, Stanel, S, Rostron, A, Coleman, C, Baguley, D, Hufton, E, Khan, F, Hall, I, Stewart, I, Fabbri, L, Wright, L, Kitterick, P, Morriss, R, Johnson, S, Bates, A, Antoniades, C, Clark, D, Bhui, K, Channon, K M, Motohashi, K, Sigfrid, L, Husain, M, Webster, M, Fu, X, Li, X, Kingham, L, Klenerman, P, Miiler, K, Carson, G, Simons, G, Huneke, N, Calder, P C, Baldwin, D, Bain, S, Lasserson, D, Daines, L, Bright, E, Stern, M, Crisp, P, Dharmagunawardena, R, Reddington, A, Wight, A, Bailey, L, Ashish, A, Robinson, E, Cooper, J, Broadley, A, Turnbull, A, Brookes, C, Sarginson, C, Ionita, D, Redfearn, H, Elliott, K, Barman, L, Griffiths, L, Guy, Z, Gill, Rhyan, Nathu, Rashmita, Harris, Edward, Moss, P, Finnigan, J, Saunders, Kathryn, Saunders, Peter, Kon, S, Kon, Samantha S, O'Brien, Linda, Shah, K, Shah, P, Richardson, Emma, Brown, V, Brown, M, Brown, Jo, Brown, J, Brown, Ammani, Brown, Angela, Choudhury, N, Jones, S, Jones, H, Jones, L, Jones, I, Jones, G, Jones, Heather, Jones, Don, Davies, Ffyon, Davies, Ellie, Davies, Kim, Davies, Gareth, Davies, Gwyneth A, Howard, K, Porter, Julie, Rowland, J, Rowland, A, Scott, Kathryn, Singh, Suver, Singh, Claire, Thomas, S, Thomas, Caradog, Lewis, Victoria, Lewis, J, Lewis, D, Harrison, P, Francis, C, Francis, R, Hughes, Rachel Ann, Hughes, Joan, Hughes, A D, Thompson, T, Kelly, S, Smith, D, Smith, Nikki, Smith, Andrew, Smith, Jacqui, Smith, Laurie, Smith, Susan, Evans, Teriann, Evans, Ranuromanana I, Evans, D, Evans, R, Evans, H, and Evans, J
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- 2023
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8. Reduced Left Atrial Rotational Flow Is Independently Associated With Embolic Brain Infarcts
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Spartera, Marco, Stracquadanio, Antonio, Pessoa-Amorim, Guilherme, Harston, George, Mazzucco, Sara, Young, Victoria, Von Ende, Adam, Hess, Aaron T., Ferreira, Vanessa M., Kennedy, James, Neubauer, Stefan, Casadei, Barbara, and Wijesurendra, Rohan S.
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- 2023
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9. Incident Clinical and Mortality Associations of Myocardial Native T1 in the UK Biobank
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Raisi-Estabragh, Zahra, McCracken, Celeste, Hann, Evan, Condurache, Dorina-Gabriela, Harvey, Nicholas C., Munroe, Patricia B., Ferreira, Vanessa M., Neubauer, Stefan, Piechnik, Stefan K., and Petersen, Steffen E.
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- 2023
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10. Acute Response in the Noninfarcted Myocardium Predicts Long-Term Major Adverse Cardiac Events After STEMI
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Shanmuganathan, Mayooran, Masi, Ambra, Burrage, Matthew K., Kotronias, Rafail A., Borlotti, Alessandra, Scarsini, Roberto, Banerjee, Abhirup, Terentes-Printzios, Dimitrios, Zhang, Qiang, Hann, Evan, Tunnicliffe, Elizabeth, Lucking, Andrew, Langrish, Jeremy, Kharbanda, Rajesh, De Maria, Giovanni Luigi, Banning, Adrian P., Choudhury, Robin P., Channon, Keith M., Piechnik, Stefan K., and Ferreira, Vanessa M.
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- 2023
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11. Clinical Utility of Cardiovascular Magnetic Resonance Before Invasive Coronary Angiography in Suspected Non-ST-segment-Elevation Myocardial Infarction
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Shanmuganathan, Mayooran, primary, Nikolaidou, Chrysovalantou, additional, Burrage, Matthew K., additional, Borlotti, Alessandra, additional, Kotronias, Rafail, additional, Scarsini, Roberto, additional, Banerjee, Abhirup, additional, Terentes-Printzios, Dimitrios, additional, Pitcher, Alex, additional, Gara, Edit, additional, Langrish, Jeremy, additional, Lucking, Andrew, additional, Choudhury, Robin, additional, De Maria, Giovanni Luigi, additional, Banning, Adrian, additional, Piechnik, Stefan K., additional, Channon, Keith M., additional, and Ferreira, Vanessa M., additional
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- 2024
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12. Neutrophils incite and macrophages avert electrical storm after myocardial infarction
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Grune, Jana, Lewis, Andrew J. M., Yamazoe, Masahiro, Hulsmans, Maarten, Rohde, David, Xiao, Ling, Zhang, Shuang, Ott, Christiane, Calcagno, David M., Zhou, Yirong, Timm, Kerstin, Shanmuganathan, Mayooran, Pulous, Fadi E., Schloss, Maximillian J., Foy, Brody H., Capen, Diane, Vinegoni, Claudio, Wojtkiewicz, Gregory R., Iwamoto, Yoshiko, Grune, Tilman, Brown, Dennis, Higgins, John, Ferreira, Vanessa M., Herring, Neil, Channon, Keith M., Neubauer, Stefan, Sosnovik, David E., Milan, David J., Swirski, Filip K., King, Kevin R., Aguirre, Aaron D., Ellinor, Patrick T., and Nahrendorf, Matthias
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- 2022
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13. Myocardial Involvement After Hospitalization for COVID-19 Complicated by Troponin Elevation: A Prospective, Multicenter, Observational Study
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Artico, Jessica, Shiwani, Hunain, Moon, James C., Gorecka, Miroslawa, McCann, Gerry P., Roditi, Giles, Morrow, Andrew, Mangion, Kenneth, Lukaschuk, Elena, Shanmuganathan, Mayooran, Miller, Christopher A., Chiribiri, Amedeo, Prasad, Sanjay K., Adam, Robert D., Singh, Trisha, Bucciarelli-Ducci, Chiara, Dawson, Dana, Knight, Daniel, Fontana, Marianna, Manisty, Charlotte, Treibel, Thomas A., Levelt, Eylem, Arnold, Ranjit, Macfarlane, Peter W., Young, Robin, McConnachie, Alex, Neubauer, Stefan, Piechnik, Stefan K., Davies, Rhodri H., Ferreira, Vanessa M., Dweck, Marc R., Berry, Colin, Greenwood, John P., Kelly, Bernard, Goreka, Miroslawa, Somers, Kathryn, Byrom-Goulthorp, Roo J., Anderson, Michelle, Britton, Laura, Richards, Fiona, Jones, Laura M., Moss, Alastair, Fisher, Jude, Wormleighton, Joanne, Parke, Kelly, Wright, Rachel, Yeo, Jian, Falconer, Judith, Harries, Valerie, Henderson, Paula, Newby, David, Popescu, Iulia, Zhang, Qiang, Raman, Betty, Channon, Keith, Krasopoulos, Catherine, Nunes, Claudia, Da Silva Rodrigues, Liliana, Nixon, Harriet, Panopoulou, Athanasia, Fletcher, Alison, Manley, Peter, Sykes, Robert, Fallon, Kirsty, Brown, Ammani, Kelly, Laura, McGinley, Christopher, Briscoe, Michael, Woodward, Rosemary, Hopkins, Tracey, McLennan, Evonne, Tynan, Nicola, Dymock, Laura, Swoboda, Peter, Wright, Judith, Exley, Donna, Steeds, Richard, Hutton, Kady, MacDonald, Sonia, Shetye, Abhishek, Orsborne, Christopher, Woodville-Jones, William, Ferguson, Susan, Bratis, Konstantinos, Fairbairn, Timothy, Sionas, Michail, Widdows, Peris, Gee Chew, Pei, Marsden, Christian, Collins, Tom, George, Linsha, Kearney, Lisa, Flett, Andrew, Smith, Simon, Zhenge, Alice, Harvey, Jake, Inacio, Liliana, Hanam-Penfold, Tomas, Gruner, Lucy, Razvi, Yousuf S.K., Crause, Jacolene, Davies, Nina M., Brown, James T., Chaco, Liza, Patel, Rishi, Kotecha, Tushar, Knight, Dan S., Green, Thomas, Ripley, David, Thompson, Maria, Cifra, Ugochi Akerele Elna, Alskaf, Ebraham, Crawley, Richard, Villa, Adriana, Nightingale, Angus K., Wright, Kim, Bonnick, Esther D., Hopkins, Emma, George, Jessy, Joseph, Linta, Cole, Graham, Vimalesvaran, Kavitha, Ali, Nadine, Carr, Caitlin R., Ross, Alexandra A.R., King, Clara, Farzad, Zohreh, Salmi, Sara A., Kirby, Kevin, McDiarmid, Adam, Stevenson, Hannah J., Matsvimbo, Pamela S., Joji, Lency, Fearby, Margaret, Brown, Benjamin, Bunce, Nicholas, Jennings, Robert, Sookhoo, Vennessa, Joshi, Shatabdi, Kanagala, Prathap, Fullalove, Sandra, Toohey, Catherine, Fenlon, Kate, Bellenger, Nicholas, He, Jingzhou, Statton, Sarah, Pamphilon, Nicola, Steele, Anna, Ball, Claire, McGahey, Ann, Balma, Silvia, Wilkes, Lynsey, Lewis, Katy, Walter, Michelle, Ionescu, Adrian, Ninan, Tishi, Richards, Suzanne, Williams, Marie, Alfakih, Khaled, Pilgrim, Samia, Joy, George, and Hussain, Ifza
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- 2023
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14. Cardiovascular Magnetic Resonance for Patients With COVID-19
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Petersen, Steffen E., Friedrich, Matthias G., Leiner, Tim, Elias, Matthew D., Ferreira, Vanessa M., Fenski, Maximilian, Flamm, Scott D., Fogel, Mark, Garg, Ria, Halushka, Marc K., Hays, Allison G., Kawel-Boehm, Nadine, Kramer, Christopher M., Nagel, Eike, Ntusi, Ntobeko A.B., Ostenfeld, Ellen, Pennell, Dudley J., Raisi-Estabragh, Zahra, Reeder, Scott B., Rochitte, Carlos E., Starekova, Jitka, Suchá, Dominika, Tao, Qian, Schulz-Menger, Jeanette, and Bluemke, David A.
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- 2022
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15. The Role of Coronary Blood Flow and Myocardial Edema in the Pathophysiology of Takotsubo Syndrome
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Couch, Liam S., primary, Thomas, Katharine E., additional, Marin, Federico, additional, Terentes-Printzios, Dimitrios, additional, Kotronias, Rafail A., additional, Chai, Jason, additional, Lukaschuk, Elena, additional, Shanmuganathan, Mayooran, additional, Kellman, Peter, additional, Langrish, Jeremy P., additional, Channon, Keith M., additional, Neubauer, Stefan, additional, Piechnik, Stefan K., additional, Ferreira, Vanessa M., additional, de Maria, Giovanni Luigi, additional, and Banning, Adrian P., additional
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- 2024
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16. Symptom Persistence Despite Improvement in Cardiopulmonary Health – Insights from longitudinal CMR, CPET and lung function testing post-COVID-19
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Cassar, Mark Philip, Tunnicliffe, Elizabeth M., Petousi, Nayia, Lewandowski, Adam J., Xie, Cheng, Mahmod, Masliza, Samat, Azlan Helmy Abd, Evans, Rachael A., Brightling, Christopher E., Ho, Ling-Pei, Piechnik, Stefan K., Talbot, Nick P., Holdsworth, David, Ferreira, Vanessa M., Neubauer, Stefan, and Raman, Betty
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- 2021
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17. Coronary Microvascular Dysfunction Assessed by Pressure Wire and CMR After STEMI Predicts Long-Term Outcomes
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Scarsini, Roberto, Shanmuganathan, Mayooran, De Maria, Giovanni Luigi, Borlotti, Alessandra, Kotronias, Rafail A., Burrage, Matthew K., Terentes-Printzios, Dimitrios, Langrish, Jeremy, Lucking, Andrew, Fahrni, Gregor, Cuculi, Florim, Ribichini, Flavio, Choudhury, Robin P., Kharbanda, Rajesh, Ferreira, Vanessa M., Channon, Keith M., and Banning, Adrian P.
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- 2021
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18. Efeitos do Exercício em Choque Cardiogênico e Balão Intra-Aórtico: Um Relato de Caso
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Ferreira, Vanessa M., primary, Rodrigues, Dayane Nunes, additional, Contreras, Carlos Alberto Mendez, additional, Rossi, João M., additional, Ramos, Rui Fernando, additional, Oliveira, Gustavo, additional, and Oliveira, Mayron F., additional
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- 2024
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19. Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART—a UK, multicentre, observational study
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Gorecka, Miroslawa, McCann, Gerry P., Berry, Colin, Ferreira, Vanessa M., Moon, James C., Miller, Christopher A., Chiribiri, Amedeo, Prasad, Sanjay, Dweck, Marc R., Bucciarelli-Ducci, Chiara, Dawson, Dana, Fontana, Marianna, Macfarlane, Peter W., McConnachie, Alex, Neubauer, Stefan, and Greenwood, John P.
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- 2021
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20. Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods
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Burrage, Matthew K., Shanmuganathan, Mayooran, Zhang, Qiang, Hann, Evan, Popescu, Iulia A., Soundarajan, Rajkumar, Chow, Kelvin, Neubauer, Stefan, Ferreira, Vanessa M., and Piechnik, Stefan K.
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- 2021
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21. Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy
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Francis, Rohin, Chong, Jun, Ramlall, Manish, Bucciarelli-Ducci, Chiara, Clayton, Tim, Dodd, Matthew, Engstrøm, Thomas, Evans, Richard, Ferreira, Vanessa M., Fontana, Marianna, Greenwood, John P., Kharbanda, Rajesh K., Kim, Won Yong, Kotecha, Tushar, Lønborg, Jacob T., Mathur, Anthony, Møller, Ulla Kristine, Moon, James, Perkins, Alexander, Rakhit, Roby D., Yellon, Derek M., Bøtker, Hans Erik, Bulluck, Heerajnarain, and Hausenloy, Derek J.
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- 2021
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22. Left atrial 4D flow cardiovascular magnetic resonance: a reproducibility study in sinus rhythm and atrial fibrillation
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Spartera, Marco, Pessoa-Amorim, Guilherme, Stracquadanio, Antonio, Von Ende, Adam, Fletcher, Alison, Manley, Peter, Neubauer, Stefan, Ferreira, Vanessa M., Casadei, Barbara, Hess, Aaron T., and Wijesurendra, Rohan S.
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- 2021
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23. Cardiovascular magnetic resonance in women with cardiovascular disease: position statement from the Society for Cardiovascular Magnetic Resonance (SCMR)
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Ordovas, Karen G., Baldassarre, Lauren A., Bucciarelli-Ducci, Chiara, Carr, James, Fernandes, Juliano Lara, Ferreira, Vanessa M., Frank, Luba, Mavrogeni, Sophie, Ntusi, Ntobeko, Ostenfeld, Ellen, Parwani, Purvi, Pepe, Alessia, Raman, Subha V., Sakuma, Hajime, Schulz-Menger, Jeanette, Sierra-Galan, Lilia M., Valente, Anne Marie, and Srichai, Monvadi B.
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- 2021
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24. Energetic Basis for Exercise-Induced Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction
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Burrage, Matthew K., Hundertmark, Moritz, Valkovič, Ladislav, Watson, William D., Rayner, Jennifer, Sabharwal, Nikant, Ferreira, Vanessa M., Neubauer, Stefan, Miller, Jack J., Rider, Oliver J., and Lewis, Andrew J.M.
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- 2021
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25. Misclassification of females and males in cardiovascular magnetic resonance parametric mapping: the importance of sex-specific normal ranges for diagnosis of health vs. disease.
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Thomas, Katharine E, Lukaschuk, Elena, Shanmuganathan, Mayooran, Kitt, Jamie A, Popescu, Iulia A, Neubauer, Stefan, Piechnik, Stefan K, and Ferreira, Vanessa M
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MYOCARDIUM physiology ,REFERENCE values ,AGE distribution ,MAGNETIC resonance imaging ,SIMULATION methods in education ,SEX distribution ,HEART beat ,DESCRIPTIVE statistics ,RESEARCH funding ,DIAGNOSTIC errors - Abstract
Aims Cardiovascular magnetic resonance parametric mapping enables non-invasive quantitative myocardial tissue characterization. Human myocardium has normal ranges of T1 and T2 values, deviation from which may indicate disease or change in physiology. Normal myocardial T1 and T2 values are affected by biological sex. Consequently, normal ranges created with insufficient numbers of each sex may result in sampling biases, misclassification of healthy values vs. disease, and even misdiagnoses. In this study, we investigated the impact of using male normal ranges for classifying female cases as normal or abnormal (and vice versa). Methods and results One hundred and forty-two healthy volunteers (male and female) were scanned on two Siemens 3T MR systems, providing averaged global myocardial T1 and T2 values on a per-subject basis. The Monte Carlo method was used to generate simulated normal ranges from these values to estimate the statistical accuracy of classifying healthy female or male cases correctly as 'normal' when using sex-specific vs. mixed-sex normal ranges. The normal male and female T1- and T2-mapping values were significantly different by sex, after adjusting for age and heart rate. Conclusion Using 15 healthy volunteers who are not sex specific to establish a normal range resulted in a typical misclassification of up to 36% of healthy females and 37% of healthy males as having abnormal T1 values and up to 16% of healthy females and 12% of healthy males as having abnormal T2 values. This paper highlights the potential adverse impact on diagnostic accuracy that can occur when local normal ranges contain insufficient numbers of both sexes. Sex-specific reference ranges should thus be routinely adopted in clinical practice. [ABSTRACT FROM AUTHOR]
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- 2024
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26. Misclassification of females and males in cardiovascular magnetic resonance parametric mapping: the importance of sex-specific normal ranges for diagnosis of health vs. disease
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Thomas, Katharine E, primary, Lukaschuk, Elena, additional, Shanmuganathan, Mayooran, additional, Kitt, Jamie A, additional, Popescu, Iulia A, additional, Neubauer, Stefan, additional, Piechnik, Stefan K, additional, and Ferreira, Vanessa M, additional
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- 2023
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27. Myocarditis as a trigger for the expression of biventricular arrhythmogenic cardiomyopathy in desmosomal gene mutation
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Johnson, Nicholas, primary, Ginks, Matthew, additional, Ferreira, Vanessa M., additional, and Kardos, Attila, additional
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- 2023
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28. Histopathologic Validation of Stress T1 Mapping in Myocardial Ischemia: Another Step toward Clinical Translation?
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Burrage, Matthew K., primary and Ferreira, Vanessa M., additional
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- 2023
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29. Histopathologic Validation of Stress T1 Mapping in Myocardial Ischemia: Another Step toward Clinical Translation?
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Burrage, Matthew K. and Ferreira, Vanessa M.
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Commentary - Published
- 2023
30. Cardiovascular magnetic resonance for evaluation of cardiac involvement in COVID-19: recommendations by the Society for Cardiovascular Magnetic Resonance
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Ferreira, Vanessa M. (author), Plein, Sven (author), Wong, Timothy C. (author), Tao, Q. (author), Raisi-Estabragh, Zahra (author), Jain, Supriya S. (author), Han, Yuchi (author), Ojha, Vineeta (author), Kim, Jiwon (author), Ferreira, Vanessa M. (author), Plein, Sven (author), Wong, Timothy C. (author), Tao, Q. (author), Raisi-Estabragh, Zahra (author), Jain, Supriya S. (author), Han, Yuchi (author), Ojha, Vineeta (author), and Kim, Jiwon (author)
- Abstract
Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic that has affected nearly 600 million people to date across the world. While COVID-19 is primarily a respiratory illness, cardiac injury is also known to occur. Cardiovascular magnetic resonance (CMR) imaging is uniquely capable of characterizing myocardial tissue properties in-vivo, enabling insights into the pattern and degree of cardiac injury. The reported prevalence of myocardial involvement identified by CMR in the context of COVID-19 infection among previously hospitalized patients ranges from 26 to 60%. Variations in the reported prevalence of myocardial involvement may result from differing patient populations (e.g. differences in severity of illness) and the varying intervals between acute infection and CMR evaluation. Standardized methodologies in image acquisition, analysis, interpretation, and reporting of CMR abnormalities across would likely improve concordance between studies. This consensus document by the Society for Cardiovascular Magnetic Resonance (SCMR) provides recommendations on CMR imaging and reporting metrics towards the goal of improved standardization and uniform data acquisition and analytic approaches when performing CMR in patients with COVID-19 infection., ImPhys/Tao group
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- 2023
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31. Women physicians in cardiovascular magnetic resonance: Past, present, and future
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Sierra-Galan, Lilia M., primary, Aggarwal, Niti R., additional, Stojanovska, Jadranka, additional, Raman, Subha V., additional, Han, Yuchi, additional, Ferreira, Vanessa M., additional, Thomas, Katharine, additional, Seiberlich, Nicole, additional, Parwani, Purvi, additional, Bucciarelli-Ducci, Chiara, additional, Baldassarre, Lauren A., additional, Mavrogeni, Sophie, additional, Ordovas, Karen, additional, Schulz-Menger, Jeanette, additional, and Bandettini, W. Patricia, additional
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- 2023
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32. Imaging Methods: Magnetic Resonance Imaging
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Thomas, Katharine E., primary, Fotaki, Anastasia, additional, Botnar, René M., additional, and Ferreira, Vanessa M., additional
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- 2023
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33. Incident Clinical and Mortality Associations of Myocardial Native T1 in the UK Biobank
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Raisi-Estabragh, Zahra, primary, McCracken, Celeste, additional, Hann, Evan, additional, Condurache, Dorina-Gabriela, additional, Harvey, Nicholas C., additional, Munroe, Patricia B., additional, Ferreira, Vanessa M., additional, Neubauer, Stefan, additional, Piechnik, Stefan K., additional, and Petersen, Steffen E., additional
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- 2022
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34. Neuropeptide‐Y Levels in ST‐Segment–Elevation Myocardial Infarction: Relationship With Coronary Microvascular Function, Heart Failure, and Mortality
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Gibbs, Thomas, primary, Tapoulal, Nidi, additional, Shanmuganathan, Mayooran, additional, Burrage, Matthew K., additional, Borlotti, Alessandra, additional, Banning, Adrian P., additional, Choudhury, Robin P., additional, Neubauer, Stefan, additional, Kharbanda, Rajesh K., additional, Ferreira, Vanessa M., additional, Channon, Keith M., additional, Herring, Neil, additional, De Maria, Giovanni Luigi, additional, Dawkins, Sam, additional, Lucking, Andrew, additional, and Langrish, Jeremy P., additional
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- 2022
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35. E Reduced left atrial rotational flow is independently associated with the risk of embolic brain infarcts
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Spartera, Marco, primary, Stracquadanio, Antonio, additional, Pessoa-Amorim, Guilherme, additional, Harston, George, additional, Mazzucco, Sara, additional, Young, Victoria, additional, Ende, Adam Von, additional, Hess, Aaron T, additional, Ferreira, Vanessa M, additional, Kennedy, James, additional, Neubauer, Stefan, additional, Casadei, Barbara, additional, and Wijesurendra, Rohan S, additional
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- 2022
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36. Cardiovascular Magnetic Resonance for Patients With COVID-19
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Petersen, Steffen E. (author), Friedrich, Matthias G. (author), Leiner, Tim (author), Elias, Matthew D. (author), Ferreira, Vanessa M. (author), Fenski, Maximilian (author), Flamm, Scott D. (author), Fogel, Mark (author), Tao, Q. (author), Petersen, Steffen E. (author), Friedrich, Matthias G. (author), Leiner, Tim (author), Elias, Matthew D. (author), Ferreira, Vanessa M. (author), Fenski, Maximilian (author), Flamm, Scott D. (author), Fogel, Mark (author), and Tao, Q. (author)
- Abstract
COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence of cardiac dysfunction. Although COVID-19–related myocarditis is likely infrequent, COVID-19–related cardiovascular histopathology findings have been reported in up to 48% of patients, raising the concern for long-term myocardial injury. Studies to date report CMR abnormalities in 26% to 60% of hospitalized patients who have recovered from COVID-19, including functional impairment, myocardial tissue abnormalities, late gadolinium enhancement, or pericardial abnormalities. In athletes post–COVID-19, CMR has detected myocarditis-like abnormalities. In children, multisystem inflammatory syndrome may occur 2 to 6 weeks after infection; associated myocarditis and coronary artery aneurysms are evaluable by CMR. At this time, our understanding of COVID-19–related cardiovascular involvement is incomplete, and multiple studies are planned to evaluate patients with COVID-19 using CMR. In this review, we summarize existing studies of CMR for patients with COVID-19 and present ongoing research. We also provide recommendations for clinical use of CMR for patients with acute symptoms or who are recovering from COVID-19., Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., ImPhys/Medical Imaging
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- 2022
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37. MOCOnet: Robust Motion Correction of Cardiovascular Magnetic Resonance T1 Mapping Using Convolutional Neural Networks
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Gonzales, Ricardo A., primary, Zhang, Qiang, additional, Papież, Bartłomiej W., additional, Werys, Konrad, additional, Lukaschuk, Elena, additional, Popescu, Iulia A., additional, Burrage, Matthew K., additional, Shanmuganathan, Mayooran, additional, Ferreira, Vanessa M., additional, and Piechnik, Stefan K., additional
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- 2021
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38. Artificial Intelligence for Contrast-Free MRI: Scar Assessment in Myocardial Infarction Using Deep Learning-Based Virtual Native Enhancement.
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Zhang, Qiang, Burrage, Matthew K., Shanmuganathan, Mayooran, Gonzales, Ricardo A., Lukaschuk, Elena, Thomas, Katharine E., Mills, Rebecca, Leal Pelado, Joana, Nikolaidou, Chrysovalantou, Popescu, Iulia A., Lee, Yung P., Zhang, Xinheng, Dharmakumar, Rohan, Myerson, Saul G., Rider, Oliver, Channon, Keith M., Neubauer, Stefan, Piechnik, Stefan K., Ferreira, Vanessa M., and Oxford Acute Myocardial Infarction (OxAMI) Study
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- 2022
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39. The impact of atrial fibrillation and stroke risk factors on left atrial blood flow characteristics
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Spartera, Marco, primary, Stracquadanio, Antonio, additional, Pessoa-Amorim, Guilherme, additional, Von Ende, Adam, additional, Fletcher, Alison, additional, Manley, Peter, additional, Ferreira, Vanessa M, additional, Hess, Aaron T, additional, Hopewell, Jemma C, additional, Neubauer, Stefan, additional, Wijesurendra, Rohan S, additional, and Casadei, Barbara, additional
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- 2021
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40. Pressure‐controlled intermittent coronary sinus occlusion improves the vasodilatory microvascular capacity and reduces myocardial injury in patients with STEMI.
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Scarsini, Roberto, Terentes‐Printzios, Dimitrios, Shanmuganathan, Mayooran, Kotronias, Rafail A., Borlotti, Alessandra, Marin, Federico, Langrish, Jeremy, Lucking, Andrew, Ribichini, Flavio, Kharbanda, Rajesh, Ferreira, Vanessa M., Channon, Keith M., De Maria, Giovanni Luigi, and Banning, Adrian P.
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- 2022
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41. impact of atrial fibrillation and stroke risk factors on left atrial blood flow characteristics.
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Spartera, Marco, Stracquadanio, Antonio, Pessoa-Amorim, Guilherme, Ende, Adam Von, Fletcher, Alison, Manley, Peter, Ferreira, Vanessa M, Hess, Aaron T, Hopewell, Jemma C, Neubauer, Stefan, Wijesurendra, Rohan S, and Casadei, Barbara
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STROKE risk factors ,ATRIAL fibrillation ,MAGNETIC resonance imaging ,BLOOD circulation ,DESCRIPTIVE statistics ,ELECTROCARDIOGRAPHY ,RESEARCH funding ,ELECTRIC countershock - Abstract
Aims Altered left atrial (LA) blood flow characteristics account for an increase in cardioembolic stroke risk in atrial fibrillation (AF). Here, we aimed to assess whether exposure to stroke risk factors is sufficient to alter LA blood flow even in the presence of sinus rhythm (SR). Methods and results We investigated 95 individuals: 37 patients with persistent AF, who were studied before and after cardioversion [Group 1; median CHA
2 DS2 -VASc = 2.0 (1.5–3.5)]; 35 individuals with no history of AF but similar stroke risk to Group 1 [Group 2; median CHA2 DS2 -VASc = 3.0 (2.0–4.0)]; and 23 low-risk individuals in SR [Group 3; median CHA2 DS2 -VASc = 0.0 (0.0–0.0)]. Cardiac function and LA flow characteristics were evaluated using cardiac magnetic resonance. Before cardioversion, Group 1 displayed impaired left ventricular (LV) and LA function, reduced LA flow velocities and vorticity, and a higher normalized vortex volume (all P < 0.001 vs. Groups 2 and 3). After restoration of SR at ≥4-week post-cardioversion, LV systolic function and LA flow parameters improved significantly (all P < 0.001 vs. pre-cardioversion) and were no longer different from those in Group 2. However, in the presence of SR, LA flow peak and mean velocity, and vorticity were lower in Groups 1 and 2 vs. Group 3 (all P < 0.01), and were associated with impaired LA emptying fraction (LAEF) and LV diastolic dysfunction. Conclusion Patients at moderate-to-high stroke risk display altered LA flow characteristics in SR in association with an LA myopathic phenotype and LV diastolic dysfunction, regardless of a history of AF. [ABSTRACT FROM AUTHOR]- Published
- 2022
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42. Clinical Significance of Myocardial Injury in Patients Hospitalized for COVID-19: A Prospective, Multicenter, Cohort Study.
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Shiwani H, Artico J, Moon JC, Gorecka M, McCann GP, Roditi G, Morrow A, Mangion K, Lukaschuk E, Shanmuganathan M, Miller CA, Chiribiri A, Alzahir M, Ramirez S, Lin A, Swoboda PP, McDiarmid AK, Sykes R, Singh T, Bucciarelli-Ducci C, Dawson D, Fontana M, Manisty C, Treibel TA, Levelt E, Arnold R, Young R, McConnachie A, Neubauer S, Piechnik SK, Davies RH, Ferreira VM, Dweck MR, Berry C, and Greenwood JP
- Abstract
Background: Hospitalized COVID-19 patients with troponin elevation have a higher prevalence of cardiac abnormalities than control individuals. However, the progression and impact of myocardial injury on COVID-19 survivors remain unclear., Objectives: This study sought to evaluate myocardial injury in COVID-19 survivors with troponin elevation with baseline and follow-up imaging and to assess medium-term outcomes., Methods: This was a prospective, longitudinal cohort study in 25 United Kingdom centers (June 2020 to March 2021). Hospitalized COVID-19 patients with myocardial injury underwent cardiac magnetic resonance (CMR) scans within 28 days and 6 months postdischarge. Outcomes were tracked for 12 months, with quality of life surveys (EuroQol-5 Dimension and 36-Item Short Form surveys) taken at discharge and 6 months., Results: Of 342 participants (median age: 61.3 years; 71.1% male) with baseline CMR, 338 had a 12-month follow-up, 235 had a 6-month CMR, and 215 has baseline and follow-up quality of life surveys. Of 338 participants, within 12 months, 1.2% died; 1.8% had new myocardial infarction, acute coronary syndrome, or coronary revascularization; 0.8% had new myopericarditis; and 3.3% had other cardiovascular events requiring hospitalization. At 6 months, there was a minor improvement in left ventricular ejection fraction (1.8% ± 1.0%; P < 0.001), stable right ventricular ejection fraction (0.4% ± 0.8%; P = 0.50), no change in myocardial scar pattern or volume (P = 0.26), and no imaging evidence of continued myocardial inflammation. All pericardial effusions (26 of 26) resolved, and most pneumonitis resolved (95 of 101). EuroQol-5 Dimension scores indicated an overall improvement in quality of life (P < 0.001)., Conclusions: Myocardial injury in severe hospitalized COVID-19 survivors is nonprogressive. Medium-term outcomes show a low incidence of major adverse cardiovascular events and improved quality of life. (COVID-19 Effects on the Heart; ISRCTN58667920)., Competing Interests: Funding Support and Author Disclosures This work was supported by NIHR (National Institute for Health and Care Research) and UK Research and Innovation (COV0254). West Yorkshire and Humber Clinical Research Network (CV070) funded the patient information leaflet translation. Dr Berry has received British Heart Foundation support (RE/18/6134217). Dr Artico received funding from the European Association of Cardiovascular Imaging (EACVI Research Grant App000073878). Dr McCann is funded by a NIHR Research Professorship (RP-2017-08-ST2-007). Dr Manisty is funded by a NIHR Clinician Scientist Award (CS-2015-15-003). Drs Ferreira, Piechnik, and Neubauer acknowledge the NIHR Oxford BRC for support of this study. Dr Bucciarelli-Ducci is in part supported by the NIHR Biomedical Research Centre at University Hospitals Bristol NHS (National Health Service) Foundation Trust and the University of Bristol. Additional support was provided by the NIHR Leicester Biomedical Research Centre and the NIHR Leeds Clinical Research Facility. Dr Dweck is supported by the British Heart Foundation (FS/SCRF/21/32010). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health and Social Care. Dr Moon has served on Advisory Boards for Sanofi and Genzyme. Dr Miller has served on Advisory Boards for Novartis, Boehringer Ingelheim and Lilly Alliance, and AstraZeneca; serves as an advisor for HAYA Therapeutics and PureTech Health; and has received research support from Amicus Therapeutics, Guerbet Laboratories Limited, Roche, and Univar Solutions B.V. Dr Bucciarelli-Ducci is the chief executive officer (part-time) of the Society for Magnetic Resonance. Dr Berry is employed by the University of Glasgow, which holds research and/or consultancy agreements with AstraZeneca, Abbott Vascular, Boehringer Ingelheim, GlaxoSmithKline, HeartFlow, Opsens, and Novartis. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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43. Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 controlled human infection study.
- Author
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Jackson S, Marshall JL, Mawer A, Lopez-Ramon R, Harris SA, Satti I, Hughes E, Preston-Jones H, Cabrera Puig I, Longet S, Tipton T, Laidlaw S, Doherty RP, Morrison H, Mitchell R, Tanner R, Ateere A, Stylianou E, Wu MS, Fredsgaard-Jones TPW, Breuer J, Rapeport G, Ferreira VM, Gleeson F, Pollard AJ, Carroll M, Catchpole A, Chiu C, and McShane H
- Subjects
- Humans, Adult, Male, Young Adult, United Kingdom epidemiology, Female, Adolescent, Healthy Volunteers, COVID-19 Vaccines immunology, COVID-19 Vaccines administration & dosage, COVID-19 Vaccines adverse effects, Antibodies, Neutralizing blood, Antibodies, Neutralizing immunology, Vaccination methods, SARS-CoV-2 immunology, COVID-19 prevention & control, COVID-19 immunology, Antibodies, Viral blood, Antibodies, Viral immunology
- Abstract
Background: A SARS-CoV-2 controlled human infection model (CHIM) has been successfully established in seronegative individuals using a dose of 1×10
1 50% tissue culture infectious dose (TCID50 ) pre-alpha SARS-CoV-2 virus. Given the increasing prevalence of seropositivity to SARS-CoV-2, a CHIM that could be used for vaccine development will need to induce infection in those with pre-existing immunity. Our aim was to find a dose of pre-alpha SARS-CoV-2 virus that induced infection in previously infected individuals., Methods: Healthy, UK volunteers aged 18-30 years, with proven (quantitative RT-PCR or lateral flow antigen test) previous SARS-CoV-2 infection (with or without vaccination) were inoculated intranasally in a stepwise dose escalation CHIM with either 1×101 , 1×102 , 1×10³, 1×104 , or 1×105 TCID50 SARS-CoV-2/human/GBR/484861/2020, the same virus used in the seronegative CHIM. Post-inoculation, volunteers were quarantined in functionally negative pressure rooms (Oxford, UK) for 14 days and until 12-hourly combined oropharyngeal-nasal swabs were negative for viable virus by focus-forming assay. Outpatient follow-up continued for 12 months post-enrolment, with additional visits for those who developed community-acquired SARS-CoV-2 infection. The primary objective was to identify a safe, well tolerated dose that induced infection (defined as two consecutive SARS-CoV-2 positive PCRs starting 24 h after inoculation) in 50% of seropositive volunteers. This study is registered with ClinicalTrials.gov (NCT04864548); enrolment and follow-up to 12 months post-enrolment are complete., Findings: Recruitment commenced on May 6, 2021, with the last volunteer enrolled into the dose escalation cohort on Nov 24, 2022. 36 volunteers were enrolled, with four to eight volunteers inoculated in each dosing group from 1×101 to 1×105 TCID50 SARS-CoV-2. All volunteers have completed quarantine, with follow-up to 12 months complete. Despite dose escalation to 1×105 TCID50 , we were unable to induce sustained infection in any volunteers. Five (14%) of 36 volunteers were considered to have transient infection, based on the kinetic of their PCR-positive swabs. Transiently infected volunteers had significantly lower baseline mucosal and systemic SARS-CoV-2-specific antibody titres and significantly lower peripheral IFNγ responses against a CD8+ T-cell SARS-CoV-2 peptide pool than uninfected volunteers. 14 (39%) of 36 volunteers subsequently developed breakthrough infection with the omicron variant after discharge from quarantine. Most adverse events reported by volunteers in quarantine were mild, with fatigue (16 [44%]) and stuffy nose (16 [44%]) being the most common. There were no serious adverse events., Interpretation: Our study demonstrates potent protective immunity induced by homologous vaccination and homologous or heterologous previous SARS-CoV-2 infection. The community breakthrough infections seen with the omicron variant supports the use of newer variants to establish a model with sufficient rate of infection for use in vaccine and therapeutic development., Funding: Wellcome Trust and Department for Health and Social Care., Competing Interests: Declaration of interests MC and SLa are supported by the Oak Foundation. TT, SLo, and SLa are supported by the US Food and Drug Administration Medical Countermeasures Initiative contract 75F40120C00085. VMF acknowledges support from the British Heart Foundation (CH/16/1/32013). AC is a full time paid employee of hVIVO. AJP is chair of the UK Department of Health and Social Care’s (DHSC) Joint Committee on Vaccination and Immunisation, was a member of WHO’s Strategic Advisory Group of Experts until 2022, receives consulting fees from Shionogi, and is in receipt of grants from the UK Medical Research Council, AstraZeneca, Gates Foundation, Wellcome Trust, National Institute for Health and Care Research (NIHR), Serum Institute of India, CEPI, and European Commission through the University of Oxford. AJP, SJ, HMo, SAH, RT, RL-R, and ICP contributed to intellectual property licensed by Oxford University Innovation to AstraZeneca. All other authors declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)- Published
- 2024
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44. The Effects of Exercise on Cardiogenic Shock with an Intra-Aortic Balloon Pump: A Case Report.
- Author
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Ferreira VM, Rodrigues DN, Contreras CAM, Rossi JM, Ramos RF, Oliveira G, and Oliveira MF
- Subjects
- Male, Humans, Middle Aged, Shock, Cardiogenic therapy, Shock, Cardiogenic etiology, Walking, Intra-Aortic Balloon Pumping adverse effects, Intra-Aortic Balloon Pumping methods, Treatment Outcome, Heart Transplantation adverse effects, Heart-Assist Devices adverse effects
- Abstract
This case report describes the exercise program on a hospitalized 54-year-old male patient with cardiogenic shock waiting for a heart transplant assisted by an intra-aortic balloon pump, a temporary mechanical circulatory support device. The temporary mechanical circulatory support device, an intra-aortic balloon pump, was placed in the left subclavian artery, enabling the exercise protocol. Measurements and values from Swan-Ganz catheter, blood sample, brain natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hs-CRP), as well as the six-minute walk test (6MWT) and venous oxygen saturation (SvO2) were obtained before and after an exercise protocol. The exercise training protocol involved the use of an unloaded bed cycle ergometer once a day, for a maximum of 30 minutes, to the tolerance limit. No adverse events or events related to the dislocation of the intra-aortic balloon pump were observed during the exercise protocol. The exercise program resulted in higher SvO2 levels, with an increased 6MWT with lower Borg dyspnea scores (312 meters vs. 488 meters and five points vs. three points, respectively). After completing the ten-day exercise protocol, the patient underwent a non-complicated heart transplant surgery and a full recovery in the ICU. This study showed that exercise is a feasible option for patients with cardiogenic shock who are using an intra-aortic balloon pump and that it is well-tolerated with no reported adverse events.
- Published
- 2024
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45. Misclassification of females and males in cardiovascular magnetic resonance parametric mapping: the importance of sex-specific normal ranges for diagnosis of health vs. disease.
- Author
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Thomas KE, Lukaschuk E, Shanmuganathan M, Kitt JA, Popescu IA, Neubauer S, Piechnik SK, and Ferreira VM
- Subjects
- Humans, Male, Female, Reference Values, Predictive Value of Tests, Reproducibility of Results, Myocardium pathology, Magnetic Resonance Spectroscopy, Magnetic Resonance Imaging, Cine methods, Heart physiology, Magnetic Resonance Imaging methods
- Abstract
Aims: Cardiovascular magnetic resonance parametric mapping enables non-invasive quantitative myocardial tissue characterization. Human myocardium has normal ranges of T1 and T2 values, deviation from which may indicate disease or change in physiology. Normal myocardial T1 and T2 values are affected by biological sex. Consequently, normal ranges created with insufficient numbers of each sex may result in sampling biases, misclassification of healthy values vs. disease, and even misdiagnoses. In this study, we investigated the impact of using male normal ranges for classifying female cases as normal or abnormal (and vice versa)., Methods and Results: One hundred and forty-two healthy volunteers (male and female) were scanned on two Siemens 3T MR systems, providing averaged global myocardial T1 and T2 values on a per-subject basis. The Monte Carlo method was used to generate simulated normal ranges from these values to estimate the statistical accuracy of classifying healthy female or male cases correctly as 'normal' when using sex-specific vs. mixed-sex normal ranges. The normal male and female T1- and T2-mapping values were significantly different by sex, after adjusting for age and heart rate., Conclusion: Using 15 healthy volunteers who are not sex specific to establish a normal range resulted in a typical misclassification of up to 36% of healthy females and 37% of healthy males as having abnormal T1 values and up to 16% of healthy females and 12% of healthy males as having abnormal T2 values. This paper highlights the potential adverse impact on diagnostic accuracy that can occur when local normal ranges contain insufficient numbers of both sexes. Sex-specific reference ranges should thus be routinely adopted in clinical practice., Competing Interests: Conflict of interest: S.K.P. has patent authorship rights for US patent US20120078084A1: ‘System and methods for shortened Look-Locker inversion recovery (Sh-MOLLI) cardiac gated mapping of T1’, granted on 15 March 2016. S.K.P., I.A.P., and V.M.F. have authorship rights for patent pending PCT/GB2020/051189: ‘A method for identity validation and quality assurance of quantitative magnetic resonance imaging protocols’, filed on 15 May 2020. IPs are owned and managed by Oxford University Innovations., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2024
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46. Quality control-driven deep ensemble for accountable automated segmentation of cardiac magnetic resonance LGE and VNE images.
- Author
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Gonzales RA, Ibáñez DH, Hann E, Popescu IA, Burrage MK, Lee YP, Altun İ, Weintraub WS, Kwong RY, Kramer CM, Neubauer S, Ferreira VM, Zhang Q, and Piechnik SK
- Abstract
Background: Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging is the gold standard for non-invasive myocardial tissue characterisation. However, accurate segmentation of the left ventricular (LV) myocardium remains a challenge due to limited training data and lack of quality control. This study addresses these issues by leveraging generative adversarial networks (GAN)-generated virtual native enhancement (VNE) images to expand the training set and incorporating an automated quality control-driven (QCD) framework to improve segmentation reliability., Methods: A dataset comprising 4,716 LGE images (from 1,363 patients with hypertrophic cardiomyopathy and myocardial infarction) was used for development. To generate additional clinically validated data, LGE data were augmented with a GAN-based generator to produce VNE images. LV was contoured on these images manually by clinical observers. To create diverse candidate segmentations, the QCD framework involved multiple U-Nets, which were combined using statistical rank filters. The framework predicted the Dice Similarity Coefficient (DSC) for each candidate segmentation, with the highest predicted DSC indicating the most accurate and reliable result. The performance of the QCD ensemble framework was evaluated on both LGE and VNE test datasets (309 LGE/VNE images from 103 patients), assessing segmentation accuracy (DSC) and quality prediction (mean absolute error (MAE) and binary classification accuracy)., Results: The QCD framework effectively and rapidly segmented the LV myocardium (<1 s per image) on both LGE and VNE images, demonstrating robust performance on both test datasets with similar mean DSC (LGE: 0.845 ± 0.075 ; VNE: 0.845 ± 0.071 ; p = n s ). Incorporating GAN-generated VNE data into the training process consistently led to enhanced performance for both individual models and the overall framework. The quality control mechanism yielded a high performance ( MAE = 0.043 , accuracy = 0.951 ) emphasising the accuracy of the quality control-driven strategy in predicting segmentation quality in clinical settings. Overall, no statistical difference ( p = n s ) was found when comparing the LGE and VNE test sets across all experiments., Conclusions: The QCD ensemble framework, leveraging GAN-generated VNE data and an automated quality control mechanism, significantly improved the accuracy and reliability of LGE segmentation, paving the way for enhanced and accountable diagnostic imaging in routine clinical use., Competing Interests: VF, QZ, and SP have authorship rights for patent WO2021/044153 (“Enhancement of Medical Images”; granted March 11, 2021). EH, IP, VF, QZ and SP have authorship rights for patent WO/2020/161481 (“Method and Apparatus for Quality Prediction”; granted August 13, 2020). SP has patent authorship rights for US patent US20120078084A1 (“Systems and Methods for Shortened Look Locker Inversion Recovery [Sh-MOLLI] Cardiac Gated Mapping of T1”; granted March 15, 2016). DI was employed by Artificio Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Gonzales, Ibáñez, Hann, Popescu, Burrage, Lee, Altun, Weintraub, Kwong, Kramer, Neubauer, Ferreira, Zhang and Piechnik.)
- Published
- 2023
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47. Acute changes in myocardial tissue characteristics during hospitalization in patients with COVID-19.
- Author
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Shanmuganathan M, Kotronias RA, Burrage MK, Ng Y, Banerjee A, Xie C, Fletcher A, Manley P, Borlotti A, Emfietzoglou M, Mentzer AJ, Marin F, Raman B, Tunnicliffe EM, Neubauer S, Piechnik SK, Channon KM, and Ferreira VM
- Abstract
Background: Patients with a history of COVID-19 infection are reported to have cardiac abnormalities on cardiovascular magnetic resonance (CMR) during convalescence. However, it is unclear whether these abnormalities were present during the acute COVID-19 illness and how they may evolve over time., Methods: We prospectively recruited unvaccinated patients hospitalized with acute COVID-19 ( n = 23), and compared them with matched outpatient controls without COVID-19 ( n = 19) between May 2020 and May 2021. Only those without a past history of cardiac disease were recruited. We performed in-hospital CMR at a median of 3 days (IQR 1-7 days) after admission, and assessed cardiac function, edema and necrosis/fibrosis, using left and right ventricular ejection fraction (LVEF, RVEF), T1-mapping, T2 signal intensity ratio (T2SI), late gadolinium enhancement (LGE) and extracellular volume (ECV). Acute COVID-19 patients were invited for follow-up CMR and blood tests at 6 months., Results: The two cohorts were well matched in baseline clinical characteristics. Both had normal LVEF (62 ± 7 vs. 65 ± 6%), RVEF (60 ± 6 vs. 58 ± 6%), ECV (31 ± 3 vs. 31 ± 4%), and similar frequency of LGE abnormalities (16 vs. 14%; all p > 0.05). However, measures of acute myocardial edema (T1 and T2SI) were significantly higher in patients with acute COVID-19 when compared to controls (T1 = 1,217 ± 41 ms vs. 1,183 ± 22 ms; p = 0.002; T2SI = 1.48 ± 0.36 vs. 1.13 ± 0.09; p < 0.001). All COVID-19 patients who returned for follow up ( n = 12) at 6 months had normal biventricular function, T1 and T2SI., Conclusion: Unvaccinated patients hospitalized for acute COVID-19 demonstrated CMR imaging evidence of acute myocardial edema, which normalized at 6 months, while biventricular function and scar burden were similar when compared to controls. Acute COVID-19 appears to induce acute myocardial edema in some patients, which resolves in convalescence, without significant impact on biventricular structure and function in the acute and short-term. Further studies with larger numbers are needed to confirm these findings., Competing Interests: SP has patent authorship rights for U.S. patent 9285446 B2 [systems and methods for Shortened Look Locker Inversion Recovery (Sh-MOLLI) cardiac gated mapping of T1], granted March 15, 2016; IPs are owned and managed by Oxford University Innovations. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Shanmuganathan, Kotronias, Burrage, Ng, Banerjee, Xie, Fletcher, Manley, Borlotti, Emfietzoglou, Mentzer, Marin, Raman, Oxford Acute Myocardial Infarction (OxAMI) investigators, Tunnicliffe, Neubauer, Piechnik, Channon and Ferreira.)
- Published
- 2023
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48. The impact of atrial fibrillation and stroke risk factors on left atrial blood flow characteristics.
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Spartera M, Stracquadanio A, Pessoa-Amorim G, Von Ende A, Fletcher A, Manley P, Ferreira VM, Hess AT, Hopewell JC, Neubauer S, Wijesurendra RS, and Casadei B
- Subjects
- Atrial Function, Left physiology, Humans, Risk Factors, Atrial Appendage, Atrial Fibrillation, Stroke complications, Stroke etiology
- Abstract
Aims: Altered left atrial (LA) blood flow characteristics account for an increase in cardioembolic stroke risk in atrial fibrillation (AF). Here, we aimed to assess whether exposure to stroke risk factors is sufficient to alter LA blood flow even in the presence of sinus rhythm (SR)., Methods and Results: We investigated 95 individuals: 37 patients with persistent AF, who were studied before and after cardioversion [Group 1; median CHA2DS2-VASc = 2.0 (1.5-3.5)]; 35 individuals with no history of AF but similar stroke risk to Group 1 [Group 2; median CHA2DS2-VASc = 3.0 (2.0-4.0)]; and 23 low-risk individuals in SR [Group 3; median CHA2DS2-VASc = 0.0 (0.0-0.0)]. Cardiac function and LA flow characteristics were evaluated using cardiac magnetic resonance. Before cardioversion, Group 1 displayed impaired left ventricular (LV) and LA function, reduced LA flow velocities and vorticity, and a higher normalized vortex volume (all P < 0.001 vs. Groups 2 and 3). After restoration of SR at ≥4-week post-cardioversion, LV systolic function and LA flow parameters improved significantly (all P < 0.001 vs. pre-cardioversion) and were no longer different from those in Group 2. However, in the presence of SR, LA flow peak and mean velocity, and vorticity were lower in Groups 1 and 2 vs. Group 3 (all P < 0.01), and were associated with impaired LA emptying fraction (LAEF) and LV diastolic dysfunction., Conclusion: Patients at moderate-to-high stroke risk display altered LA flow characteristics in SR in association with an LA myopathic phenotype and LV diastolic dysfunction, regardless of a history of AF., (© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2021
- Full Text
- View/download PDF
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