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29 results on '"Ferman, Tanis J"'

1. Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies

Author

Mak, Elijah, Reid, Robert I., Przybelski, Scott A., Lesnick, Timothy G., Schwarz, Christopher G., Senjem, Matthew L., Raghavan, Sheelakumari, Vemuri, Prashanthi, Jack, Jr, Clifford R., Min, Hoon Ki, Jain, Manoj K., Miyagawa, Toji, Forsberg, Leah K., Fields, Julie A., Savica, Rodolfo, Graff-Radford, Jonathan, Jones, David T., Botha, Hugo, St. Louis, Erik K., Knopman, David S., Ramanan, Vijay K., Dickson, Dennis W., Graff-Radford, Neill R., Ferman, Tanis J., Petersen, Ronald C., Lowe, Val J., Boeve, Bradley F., O’Brien, John T., and Kantarci, Kejal

Published
2024
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2. Role of GBA variants in Lewy body disease neuropathology

Author

Walton, Ronald L., Koga, Shunsuke, Beasley, Alexandra I., White, Launia J., Griesacker, Teresa, Murray, Melissa E., Kasanuki, Koji, Hou, Xu, Fiesel, Fabienne C., Springer, Wolfdieter, Uitti, Ryan J., Fields, Julie A., Botha, Hugo, Ramanan, Vijay K., Kantarci, Kejal, Lowe, Val J., Jack, Clifford R., Ertekin-Taner, Nilufer, Savica, Rodolfo, Graff-Radford, Jonathan, Petersen, Ronald C., Parisi, Joseph E., Reichard, R. Ross, Graff-Radford, Neill R., Ferman, Tanis J., Boeve, Bradley F., Wszolek, Zbigniew K., Dickson, Dennis W., Ross, Owen A., and Heckman, Michael G.

Published
2024
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4. Cross-sectional Associations of β-Amyloid, Tau, and Cerebrovascular Biomarkers With Neurodegeneration in Probable Dementia With Lewy Bodies

Author

Ferreira, Daniel, Przybelski, Scott A, Lesnick, Timothy G, Schwarz, Christopher G, Diaz-Galvan, Patricia, Graff-Radford, Jonathan, Senjem, Matthew L, Fields, Julie A, Knopman, David S, Jones, David T., Savica, Rodolfo, Ferman, Tanis J., Graff-Radford, Neill, Lowe, Val J., Jack, Clifford R., Petersen, Ronald C, Westman, Eric, Boeve, Brad F, and Kantarci, Kejal

Published
2022
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5. Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures

Author

Valentino, Rebecca R., Ramnarine, Chloe, Heckman, Michael G., Johnson, Patrick W., Soto-Beasley, Alexandra I., Walton, Ronald L., Koga, Shunsuke, Kasanuki, Koji, Murray, Melissa E., Uitti, Ryan J., Fields, Julie A., Botha, Hugo, Ramanan, Vijay K., Kantarci, Kejal, Lowe, Val J., Jack, Clifford R., Ertekin-Taner, Nilufer, Savica, Rodolfo, Graff-Radford, Jonathan, Petersen, Ronald C., Parisi, Joseph E., Reichard, R. Ross, Graff-Radford, Neill R., Ferman, Tanis J., Boeve, Bradley F., Wszolek, Zbigniew K., Dickson, Dennis W., and Ross, Owen A.

Published
2022
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6. Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease

Author

Kouri, Naomi, primary, Frankenhauser, Isabelle, additional, Peng, Zhongwei, additional, Labuzan, Sydney A., additional, Boon, Baayla D. C., additional, Moloney, Christina M., additional, Pottier, Cyril, additional, Wickland, Daniel P., additional, Caetano-Anolles, Kelsey, additional, Corriveau-Lecavalier, Nick, additional, Tranovich, Jessica F., additional, Wood, Ashley C., additional, Hinkle, Kelly M., additional, Lincoln, Sarah J., additional, Spychalla, A. J., additional, Senjem, Matthew L., additional, Przybelski, Scott A., additional, Engelberg-Cook, Erica, additional, Schwarz, Christopher G., additional, Kwan, Rain S., additional, Lesser, Elizabeth R., additional, Crook, Julia E., additional, Carter, Rickey E., additional, Ross, Owen A., additional, Lachner, Christian, additional, Ertekin-Taner, Nilüfer, additional, Ferman, Tanis J., additional, Fields, Julie A., additional, Machulda, Mary M., additional, Ramanan, Vijay K., additional, Nguyen, Aivi T., additional, Reichard, R. Ross, additional, Jones, David T., additional, Graff-Radford, Jonathan, additional, Boeve, Bradley F., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, Kantarci, Kejal, additional, Day, Gregory S., additional, Duara, Ranjan, additional, Graff-Radford, Neill R., additional, Dickson, Dennis W., additional, Lowe, Val J., additional, Vemuri, Prashanthi, additional, and Murray, Melissa E., additional

Published
2024
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8. Lewy body dementia: Overcoming barriers and identifying solutions

Author

Agarwal, Kanishka, primary, Backler, Wendi, additional, Bayram, Ece, additional, Bloom, Leah, additional, Boeve, Bradley F., additional, Cha, Jang‐Ho, additional, Denslow, Maria, additional, Ferman, Tanis J., additional, Galasko, Douglas, additional, Galvin, James E., additional, Gomperts, Stephen N., additional, Irizarry, Michael C., additional, Kantarci, Kejal, additional, Kaushik, Harsh, additional, Kietlinski, Matt, additional, Koenig, Aaron, additional, Leverenz, James B., additional, McKeith, Ian, additional, McLean, Pamela J., additional, Montine, Thomas J., additional, Moose, Sandra O., additional, O'Brien, John T., additional, Panier, Valery, additional, Ramanathan, Sharad, additional, Ringel, Michael S., additional, Scholz, Sonja W., additional, Small, Jonnell, additional, Sperling, Reisa A., additional, Taylor, Angela, additional, Taylor, John‐Paul, additional, Ward, Rebecca A., additional, Witten, Lisa, additional, and Hyman, Bradley T., additional

Published
2024
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9. Longitudinal Free‐Water Changes in Dementia with Lewy Bodies.

Author

Chiu, Shannon Y., Chen, Robin, Wang, Wei‐en, Armstrong, Melissa J., Boeve, Bradley F., Savica, Rodolfo, Ramanan, Vijay, Fields, Julie A., Graff‐Radford, Neill, Ferman, Tanis J., Kantarci, Kejal, and Vaillancourt, David E.

Abstract

Background: Diffusion‐weighted magnetic resonance imaging (dMRI) examines tissue microstructure integrity in vivo. Prior dementia with Lewy bodies (DLB) diffusion tensor imaging studies yielded mixed results. Objective: We employed free‐water (FW) imaging to assess DLB progression and correlate with clinical decline in DLB. Methods: Baseline and follow‐up MRIs were obtained at 12 and/or 24 months for 27 individuals with DLB or mild cognitive impairment with Lewy bodies (MCI‐LB). FW was analyzed using the Mayo Clinic Adult Lifespan Template. Primary outcomes were FW differences between baseline and 12 or 24 months. To compare FW change longitudinally, we included 20 cognitively unimpaired individuals from the Alzheimer's Disease Neuroimaging Initiative. Results: We followed 23 participants to 12 months and 16 participants to 24 months. Both groups had worsening in Montreal Cognitive Assessment (MoCA) and Movement Disorder Society‐Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) scores. We found significant FW increases at both time points compared to baseline in the insula, amygdala, posterior cingulum, parahippocampal, entorhinal, supramarginal, fusiform, retrosplenial, and Rolandic operculum regions. At 24 months, we found more widespread microstructural changes in regions implicated in visuospatial processing, motor, and cholinergic functions. Between‐group analyses (DLB vs. controls) confirmed significant FW changes over 24 months in most of these regions. FW changes were associated with longitudinal worsening of MDS‐UPDRS and MoCA scores. Conclusions: FW increased in gray and white matter regions in DLB, likely due to neurodegenerative pathology associated with disease progression. FW change was associated with clinical decline. The findings support dMRI as a promising tool to track disease progression in DLB. © 2024 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Comparative assessment of α‐synuclein seeding activities in the cerebrospinal fluid of MCI patients phenoconverting to DLB

Author

Atik, Merve, primary, Kondru, Naveen Chandra, additional, Savica, Rodolfo, additional, Ramanan, Vijay K, additional, Graff‐Radford, Jonathan, additional, Fields, Julie A., additional, Graff‐Radford, Neill R, additional, Day, Gregory S., additional, Ferman, Tanis J, additional, Forsberg, Leah K., additional, Boeve, Brad F., additional, Kantarci, Kejal, additional, and Ross, Owen A., additional

Published
2023
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12. Automated Analysis of REM Sleep without Atonia in the Lewy Body Disease Spectrum

Author

Strainis, Emma P., primary, Jagielski, Jack T., additional, LeClair‐Visonneau, Laurene, additional, Przybelski, Scott A., additional, Feemster, John C, additional, McCarter, Stuart J, additional, Carvalho, Diego Z., additional, Silber, Michael H, additional, Vemuri, Prashanthi, additional, Jack, Clifford R., additional, Miyagawa, Toji, additional, Forsberg, Leah K., additional, Fields, Julie A., additional, Savica, Rodolfo, additional, Graff‐Radford, Jonathan, additional, Jones, David T., additional, Botha, Hugo, additional, Ramanan, Vijay K, additional, Knopman, David S., additional, Graff‐Radford, Neill R, additional, Ferman, Tanis J, additional, Petersen, Ronald C., additional, Lowe, Val J., additional, Boeve, Brad F., additional, Kantarci, Kejal, additional, Dredla, Brynn, additional, and Louis, Erik K St, additional

Published
2023
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14. Plasma biomarkers of Alzheimer´s disease in the continuum of dementia with Lewy bodies

Author

Diaz‐Galvan, Patricia, primary, Przybelski, Scott A., additional, Algeciras‐Schimnich, Alicia, additional, Lesnick, Timothy G., additional, Schwarz, Christopher G., additional, Senjem, Matthew L., additional, Gunter, Jeffrey L., additional, Jack, Clifford R., additional, Min, Paul H, additional, Jain, Manoj K., additional, Miyagawa, Toji, additional, Forsberg, Leah K., additional, Fields, Julie A., additional, Savica, Rodolfo, additional, Graff‐Radford, Jonathan, additional, Ramanan, Vijay K, additional, Jones, David T., additional, Botha, Hugo, additional, St. Louis, Erik K, additional, Knopman, David S., additional, Graff‐Radford, Neill R, additional, Ferman, Tanis J, additional, Petersen, Ronald C., additional, Lowe, Val J., additional, Boeve, Brad F., additional, and Kantarci, Kejal, additional

Published
2023
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15. Alzheimer’s disease biomarkers of amyloid and tau influence white matter neurite alterations in dementia with Lewy bodies: a NODDI study

Author

Mak, Elijah, primary, Reid, Robert I., additional, Przybelski, Scott A., additional, Lesnick, Timothy G., additional, Schwarz, Christopher G., additional, Senjem, Matthew L., additional, Raghavan, Sheelakumari, additional, Vemuri, Prashanthi, additional, Jack, Clifford R., additional, Min, Hoon‐Ki, additional, Jain, Manoj K., additional, Miyagawa, Toji, additional, Forsberg, Leah K., additional, Fields, Julie A., additional, Savica, Rodolfo, additional, Graff‐Radford, Jonathan, additional, Jones, David T., additional, Botha, Hugo, additional, St. Louis, Erik K, additional, Knopman, David S., additional, Ramanan, Vijay K, additional, Graff‐Radford, Neill R, additional, Ferman, Tanis J, additional, Petersen, Ronald C., additional, Lowe, Val J., additional, Boeve, Brad F., additional, O'Brien, John T, additional, and Kantarci, Kejal, additional

Published
2023
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16. Retrospective Evaluation of Neuropathologic Proxies of the Minimal Atrophy Subtype Compared With Corticolimbic Alzheimer Disease Subtypes

Author

Boon, Baayla D.C., primary, Labuzan, Sydney A., additional, Peng, Zhongwei, additional, Matchett, Billie J., additional, Kouri, Naomi, additional, Hinkle, Kelly M., additional, Lachner, Christian, additional, Ross, Owen A., additional, Ertekin-Taner, Nilufer, additional, Carter, Rickey E., additional, Ferman, Tanis J., additional, Duara, Ranjan, additional, Dickson, Dennis W., additional, Graff-Radford, Neill R., additional, and Murray, Melissa E., additional

Published
2023
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17. Disparate Dementia Risk Factors Are Associated with Cognitive Impairment and Rates of Decline in African Americans.

Author

Lachner, Christian, Craver, Emily C., Babulal, Ganesh M., Lucas, John A., Ferman, Tanis J., White, Richard O., Graff‐Radford, Neill R., and Day, Gregory S.

Subjects
DISEASE risk factors, COGNITION disorders, VITAMIN B12 deficiency, AFRICAN Americans, ALZHEIMER'S disease
Abstract

Objective: This study was undertaken to evaluate the frequency of modifiable dementia risk factors and their association with cognitive impairment and rate of decline in diverse participants engaged in studies of memory and aging. Methods: Modifiable dementia risk factors and their associations with cognitive impairment and cognitive decline were determined in community‐dwelling African American (AA; n = 261) and non‐Hispanic White (nHW; n = 193) participants who completed ≥2 visits at the Mayo Clinic Alzheimer Disease Research Center in Jacksonville, Florida. Risk factors and their associations with cognitive impairment (global Clinical Dementia Rating [CDR] ≥ 0.5) and rates of decline (CDR Sum of Boxes) in impaired participants were compared in AA and nHW participants, controlling for demographics, APOE ɛ4 status, and Area Deprivation Index. Results: Hypertension, hypercholesterolemia, obesity, and diabetes were overrepresented in AA participants, but were not associated with cognitive impairment. Depression was associated with increased odds of cognitive impairment in AA (odds ratio [OR] = 4.30, 95% confidence interval [CI] = 2.13–8.67) and nHW participants (OR = 2.79, 95% CI = 1.21–6.44) but uniquely associated with faster decline in AA participants (β = 1.71, 95% CI = 0.69–2.73, p = 0.001). Fewer AA participants reported antidepressant use (9/49, 18%) than nHW counterparts (57/78, 73%, p < 0.001). Vitamin B12 deficiency was also associated with an increased rate of cognitive decline in AA participants (β = 2.65, 95% CI = 0.38–4.91, p = 0.023). Interpretation: Modifiable dementia risk factors are common in AA and nHW participants, representing important risk mitigation targets. Depression was associated with dementia in AA and nHW participants, and with accelerated declines in cognitive function in AA participants. Optimizing depression screening and treatment may improve cognitive trajectories and outcomes in AA participants. ANN NEUROL 2024;95:518–529 [ABSTRACT FROM AUTHOR]

Published
2024
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18. β-Amyloid Load on PET Along the Continuum of Dementia With Lewy Bodies

Author

Diaz-Galvan, Patricia, primary, Przybelski, Scott A, additional, Lesnick, Timothy G, additional, Schwarz, Christopher G, additional, Senjem, Matthew L, additional, Gunter, Jeffrey L, additional, Jack, Clifford R., additional, Paul Min, Hoon-Ki, additional, Jain, Manoj, additional, Miyagawa, Toji, additional, Forsberg, Leah K, additional, Fields, Julie A, additional, Savica, Rodolfo, additional, Graff-Radford, Jonathan, additional, Jones, David T., additional, Botha, Hugo, additional, St Louis, Erik K., additional, Knopman, David S, additional, Ramanan, Vijay K, additional, Ross, Owen, additional, Graff-Radford, Neill, additional, Day, Gregory S, additional, Dickson, Dennis W., additional, Ferman, Tanis J., additional, Petersen, Ronald C, additional, Lowe, Val J., additional, Boeve, Brad F, additional, and Kantarci, Kejal, additional

Published
2023
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19. Clinicoradiologic Correlates of Corticolimbic Index (CLix) and Glial Activation Differences Among Neuropathologic Subtypes of Alzheimer's Disease: A Retrospective Study

Author

Kouri, Naomi, primary, Frankenhauser, Isabelle, additional, Peng, Zhongwei, additional, Labuzan, Sydney A., additional, Boon, Baayla D.C., additional, Moloney, Christina M., additional, Pottier, Cyril, additional, Wickland, Daniel P., additional, Caetano-Anolles, Kelsey, additional, Corriveau-Lecavalier, Nick, additional, Tranovich, Jessica F., additional, Wood, Ashley C., additional, Hinkle, Kelly M., additional, Lincoln, Sarah J., additional, Spychalla, Anthony J., additional, Senjem, Matthew L., additional, Przybelski, Scott A., additional, Engelberg-Cook, Erica, additional, Schwarz, Christopher G., additional, Kwan, Rain S., additional, Lesser, Elizabeth R., additional, Crook, Julia E., additional, Carter, Rickey, additional, Ross, Owen A., additional, Lachner, Christian, additional, Ertekin-Taner, Nilüfer, additional, Ferman, Tanis J., additional, Machulda, Mary M., additional, Ramanan, Vijay K., additional, Nguyen, Aivi T., additional, Reichard, R. Ross, additional, Jones, David T., additional, Graff-Radford, Jonathan, additional, Boeve, Bradley F., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Jack Jr., Clifford R., additional, Kantarci, Kejal, additional, Day, Gregory S., additional, Duara, Ranjan, additional, Graff-Radford, Neill R., additional, Dickson, Dennis W., additional, Lowe, Val J., additional, Vemuri, Prashanthi, additional, and Murray, Melissa E., additional

Published
2023
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20. Amyloid PET in the Lewy Body disease continuum

Author

Diaz‐Galvan, Patricia, primary, Przybelski, Scott A., additional, Lesnick, Timothy G., additional, Schwarz, Christopher G., additional, Senjem, Matthew L., additional, Gunter, Jeffrey L., additional, Jack, Clifford R., additional, Min, Paul H, additional, Jain, Manoj K., additional, Miyagawa, Toji, additional, Forsberg, Leah K., additional, Fields, Julie A., additional, Savica, Rodolfo, additional, Graff‐Radford, Jonathan, additional, St, Erik K, additional, Knopman, David S., additional, Graff‐Radford, Neill R., additional, Ferman, Tanis J, additional, Petersen, Ronald C., additional, Lowe, Val J., additional, Boeve, Bradley F., additional, and Kantarci, Kejal, additional

Published
2022
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21. Baseline and Longitudinal Ioflupane SPECT Findings in DLB and MCI‐LB

Author

Boeve, Bradley F., primary, Miyagawa, Toji, additional, Przybelski, Scott A., additional, Min, Paul H, additional, Jordan, Lennon, additional, Lesnick, Tim, additional, Savica, Rodolfo, additional, Graff‐Radford, Jonathan, additional, Jones, David T., additional, Botha, Hugo, additional, Ramanan, Vijay K, additional, Knopman, David S., additional, Petersen, Ronald C., additional, Graff‐Radford, Neill R., additional, Day, Gregory S, additional, Fields, Julie A., additional, Machulda, Mary M., additional, Ferman, Tanis J, additional, Forsberg, Leah K., additional, Diaz‐Galvan, Patricia, additional, Li, Wentao, additional, Christine, Cliatt Brown J, additional, Jack, Clifford R., additional, Jain, Manoj K., additional, Kantarci, Kejal, additional, and Lowe, Val J., additional

Published
2022
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22. Identification of a sex-specific genetic signature in dementia with Lewy bodies: a meta-analysis of genome-wide association studies

Author

Gibbons, Elizabeth, primary, Rongve, Arvid, additional, de Rojas, Itziar, additional, Shadrin, Alexey, additional, Westra, Kaitlyn, additional, Baumgartner, Allison, additional, Rosendall, Levi, additional, Madaj, Zachary, additional, Hernandez, Dena G., additional, Ross, Owen A., additional, Escott-Price, Valentina, additional, Shepherd, Claire, additional, Parkkinen, Laura, additional, Scholz, Sonja W., additional, Troncoso, Juan C., additional, Pletnikova, Olga, additional, Dawson, Ted, additional, Rosenthal, Liana, additional, Ansorge, Olaf, additional, Clarimon, Jordi, additional, Lleo, Alberto, additional, Morenas-Rodriguez, Estrella, additional, Clark, Lorraine, additional, Honig, Lawrence S, additional, Marder, Karen, additional, Lemstra, Afina, additional, Rogaeva, Ekaterina, additional, George-Hyslop, Peter St., additional, Londos, Elisabet, additional, Zetterberg, Henrik, additional, Morgan, Kevin, additional, Troakes, Claire, additional, Al-Sarraj, Safa, additional, Lashley, Tammaryn, additional, Holton, Janice, additional, Compta, Yaroslau, additional, Van Deerlin, Vivianna, additional, Serrano, Geidy E, additional, Beach, Thomas G, additional, Lesage, Suzanne, additional, Galasko, Douglas, additional, Masliah, Eliezer, additional, Santana, Isabel, additional, Pastor, Pau, additional, Diez-Fairen, Monica, additional, Aguilar, Miquel, additional, Marquie, Marta, additional, Garcia-Gonzalez, Pablo, additional, Olive, Claudia, additional, Puerta, Raquel, additional, Cano, Amanda, additional, Sotolongo-Grau, Oscar, additional, Valero, Sergi, additional, Pytel, Vanesa Veronica, additional, Rosende-Roca, Maitee, additional, Alegret, Montserrat, additional, Tarraga, Lluis, additional, Boada, Merce, additional, Carracedo, Angel, additional, Franco-Macias, Emilio, additional, Perez-Tur, Jordi, additional, Royo, Jose Luis, additional, Garcia-Alberca, Jose Maria, additional, Real, Luis Miguel, additional, Saez, Maria Eugenia, additional, Bullido, Maria Jesus, additional, Calero, Miguel, additional, Medina, Miguel, additional, Mir, Pablo, additional, Sanchez-Juan, Pascual, additional, Alvarez, Victoria, additional, Parveen, Kayenat, additional, Tripathi, Kumar Parijat, additional, Heilmann-Heimbach, Stefanie, additional, Ramirez, Alfredo, additional, Tienari, Pentti J., additional, Bousiges, Olivier, additional, Blanc, Frederic, additional, Fenoglio, Chiara, additional, Padovani, Alessandro, additional, Borroni, Barbara, additional, Pilotto, Andrea, additional, Nobili, Flavio, additional, Saltvedt, Ingvild, additional, Fladby, Tormod, additional, Selbaek, Geir, additional, Bosnes, Ingunn, additional, Brathen, Geir, additional, Hartmann, Annette, additional, Lemstra, Afina W., additional, Rujescu, Dan, additional, Mollenhauer, Brit, additional, Creese, Byron, additional, Chartier-Harlin, Marie-Christine, additional, Athanasiu, Lavinia, additional, Djurovic, Srdjan, additional, Chouliaras, Leonidas, additional, OBrien, John T., additional, Myllykangas, Liisa, additional, Oinas, Minna, additional, Revesz, Tamas, additional, Lees, Andrew, additional, Boeve, Brad F, additional, Petersen, Ronald C., additional, Ferman, Tanis J, additional, Graff-Radford, Neill, additional, Cairns, Nigel J., additional, Morris, John C., additional, Halliday, Glenda M., additional, Hardy, John, additional, Dickson, Dennis W., additional, Singleton, Andrew, additional, Stone, David J., additional, Andreassen, Ole A., additional, Ruiz, Agustin, additional, Aarsland, Dag, additional, Guerreiro, Rita, additional, and Bras, Jose, additional

Published
2022
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23. Longitudinal Tau Positron Emission Tomography in Dementia with Lewy Bodies

Author

Chen, Qin, primary, Przybelski, Scott A., additional, Senjem, Matthew L., additional, Schwarz, Christopher G., additional, Lesnick, Timothy G., additional, Botha, Hugo, additional, Knopman, David S., additional, Graff‐Radford, Jonathan, additional, Savica, Rodolfo, additional, Jones, David T., additional, Fields, Julie A., additional, Jain, Manoj K., additional, Graff‐Radford, Neill R., additional, Ferman, Tanis J., additional, Kremers, Walter K., additional, Jack, Clifford R., additional, Petersen, Ronald C., additional, Boeve, Bradley F., additional, Lowe, Val J., additional, and Kantarci, Kejal, additional

Published
2022
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24. Longitudinal atrophy in prodromal dementia with Lewy bodies points to cholinergic degeneration

Author

Kantarci, Kejal, primary, Nedelska, Zuzana, additional, Chen, Qin, additional, Senjem, Matthew L., additional, Schwarz, Christopher G., additional, Gunter, Jeffrey L., additional, Przybelski, Scott A., additional, Lesnick, Timothy G., additional, Kremers, Walter K., additional, Fields, Julie A., additional, Graff-Radford, Jonathan, additional, Savica, Rodolfo, additional, Jones, David, additional, Botha, Hugo, additional, Knopman, David S., additional, Lowe, Val, additional, Graff-Radford, Neill R., additional, Murray, Melissa M., additional, Dickson, Dennis W., additional, Reichard, R. Ross, additional, Jack, Clifford R., additional, Petersen, Ronald C., additional, Ferman, Tanis J., additional, and Boeve, Bradley F., additional

Published
2022
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25. Cross-sectional Associations of β-Amyloid, Tau, and Cerebrovascular Biomarkers With Neurodegeneration in Probable Dementia With Lewy Bodies.

Author

Ferreira, Daniel, Przybelski, Scott A., Lesnick, Timothy G., Schwarz, Christopher G., Diaz-Galvan, Patricia, Graff-Radford, Jonathan, Senjem, Matthew L., Fields, Julie A., Knopman, David S., Jones, David T., Savica, Rodolfo, Ferman, Tanis J., Graff-Radford, Neill, Lowe, Val J., Jack, Clifford R., Petersen, Ronald C., Westman, Eric, Boeve, Brad F., and Kantarci, Kejal

Published
2023
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26. The association of amyloid‐beta, tau, and cerebrovascular biomarkers with neurodegeneration in dementia with Lewy bodies.

Author

Ferreira, Daniel, Przybelski, Scott A., Lesnick, Timothy G., Schwarz, Christopher G., Diaz‐Galvan, Patricia, Graff‐Radford, Jonathan, Senjem, Matthew L., Fields, Julie A., Savica, Rodolfo, Ferman, Tanis J, Graff‐Radford, Neill R, Lowe, Val J., Jack, Clifford R., Petersen, Ronald C., Westman, Eric, Boeve, Brad F., and Kantarci, Kejal

Abstract

Background: Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). While alpha‐synuclein pathology is the hallmark of DLB, AD and cerebrovascular pathologies are common in DLB patients. However, the contribution of these pathologies towards neurodegeneration in DLB is largely unknown. We investigated associations of amyloid‐beta, tau, and cerebrovascular biomarkers with regional gray matter (GM) volume in DLB patients and cognitively unimpaired (CU) controls. Method: We included 30 DLB patients (69.3±10.2 years old, 87% men) and 100 CU individuals balanced on age and sex (Table 1). We used 11C‐Pittsburgh Compound‐B (PiB) and 18F‐Flortaucipir positron emission tomography (PET) to assess amyloid‐beta and tau in‐vivo. We used structural MRI to assess white matter hyperintensity (WMH) volume, a marker of cerebrovascular lesion load, and regional GM volume (a marker of neurodegeneration). We used correlations and ANCOVA in the whole dataset and structural equation modelling in the DLB patients to investigate associations of WMH volume and regional amyloid‐beta and tau PET standardized uptake value ratios (SUVRs) with regional GM volume. Result: DLB patients showed lower GM volume across all cortical and subcortical regions except for cuneus, putamen, and pallidum (Fig.1). Greater WMH volume was associated with lower volume in the medial and orbital frontal cortices, insula, fusiform cortex, and thalamus in DLB patients (Fig.2). Greater PiB SUVR was associated with lower volume in the inferior temporal cortex, while Flortaucipir SUVR did not correlate with GM volume (Fig.2). Structural equation modelling showed that higher age and positivity for the APOE e4 genotype were significant predictors of greater WMH, and WMH in turn was a significant predictor of GM volume in medial and orbital frontal cortices, insula, and inferior temporal cortex (Fig.3). In contrast, we observed two distinct paths for the fusiform cortex, with age having an effect through PiB and Flortaucipir SUVRs on the one path, and through WMH on the other path (Fig.3). Conclusion: DLB patients have widespread cortical atrophy, most of which likely is influenced by alpha‐synuclein pathology. Although amyloid‐beta, tau, and cerebrovascular pathologies often coexist in DLB, their contributions to neurodegeneration seem to be region specific. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Plasma biomarkers of Alzheimer's disease in the continuum of dementia with Lewy bodies.

Author

Diaz-Galvan P, Przybelski SA, Algeciras-Schimnich A, Figdore DJ, Lesnick TG, Schwarz CG, Senjem ML, Gunter JL, Jack CR Jr, Min PH, Jain MK, Miyagawa T, Forsberg LK, Fields JA, Savica R, Graff-Radford J, Ramanan VK, Jones DT, Botha H, St Louis EK, Knopman DS, Graff-Radford NR, Ferman TJ, Petersen RC, Lowe VJ, Boeve BF, and Kantarci K

Subjects
Humans, Amyloid beta-Peptides, tau Proteins, Biomarkers metabolism, Alzheimer Disease diagnosis, Lewy Body Disease diagnosis, Cognitive Dysfunction diagnosis, REM Sleep Behavior Disorder
Abstract

Introduction: Patients with dementia with Lewy bodies (DLB) may have Alzheimers disease (AD) pathology that can be detected by plasma biomarkers. Our objective was to evaluate plasma biomarkers of AD and their association with positron emission tomography (PET) biomarkers of amyloid and tau deposition in the continuum of DLB, starting from prodromal stages of the disease., Methods: The cohort included patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD), mild cognitive impairment with Lewy bodies (MCI-LB), or DLB, with a concurrent blood draw and PET scans., Results: Abnormal levels of plasma glial fibrillary acidic protein (GFAP) were found at the prodromal stage of MCI-LB in association with increased amyloid PET. Abnormal levels of plasma phosphorylated tau (p-tau)-181 and neurofilament light (NfL) were found at the DLB stage. Plasma p-tau-181 showed the highest accuracy in detecting abnormal amyloid and tau PET in patients with DLB., Discussion: The range of AD co-pathology can be detected with plasma biomarkers in the DLB continuum, particularly with plasma p-tau-181 and GFAP., (© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

Published
2024
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29. The temporal onset of the core features in dementia with Lewy bodies.

Author

Choudhury P, Graff-Radford J, Aakre JA, Wurtz L, Knopman DS, Graff-Radford NR, Kantarci K, Forsberg LK, Fields JA, Pedraza O, Chen Q, Miyagawa T, Day GS, Tipton P, Savica R, Botha H, Lachner C, Dredla B, Reichard RR, Petersen RC, Dickson DW, Boeve BF, and Ferman TJ

Subjects
Female, Humans, Male, Lewy Body Disease pathology, Parkinsonian Disorders, REM Sleep Behavior Disorder complications, REM Sleep Behavior Disorder diagnosis
Abstract

Introduction: We examined the temporal sequence of the core features in probable dementia with Lewy bodies (DLB)., Methods: In 488 patients with probable DLB, the onset of each core feature and time to diagnosis was determined for men and women, and a pathologic subgroup (n = 209)., Results: REM sleep behavior disorder (RBD) developed before the other core features in men and women. Men were more likely to have RBD and were diagnosed with probable DLB earlier than women. Visual hallucinations developed after the other core features in men, but in women, they appeared earlier and concurrently with fluctuations and parkinsonism. Women were older and more cognitively impaired at first visit, were less likely to have RBD, more likely to be diagnosed with probable DLB later than men, and more likely to have neocortical tangles., Discussion: An earlier latency to probable DLB was associated with men, RBD, and Lewy body disease without neocortical tangles., (© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

Published
2022
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