1. Inhibition of bone resorption by nanoparticle drug delivery system
- Author
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Li, Meng Ya, Sun, Jian, Zhao, Dong, Zhang, Wen, Xu, Qing An, and Fan, Ming Wen
- Abstract
Controlling and reducing plaque formation plays a pivotal role in preventing and treating periodontal diseases, often utilizing antibacterial drugs to enhance therapeutic outcomes. Mesoporous silica nanoparticles (MSN), an FDA-approved inorganic nanomaterial, possess robust physical and chemical properties such as adjustable pore size, pore capacity, easy surface modification, and high biosafety. Numerous studies have exploited MSN to regulate drug release and facilitate targeted delivery. This study aimed to synthesize a MSN-tetracycline (MSN-TC) complex and investigate its inhibitory potential on Porphyromonas gingivalis (P. gingivalis)-induced bone resorption.
- Published
- 2024
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