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1. Plasma extracellular vesicles reveal early molecular differences in amyloid positive patients with early-onset mild cognitive impairment

Author

Cano, Amanda, Esteban-de-Antonio, Ester, Bernuz, Mireia, Puerta, Raquel, García-González, Pablo, de Rojas, Itziar, Olivé, Claudia, Pérez-Cordón, Alba, Montrreal, Laura, Núñez-Llaves, Raúl, Sotolongo-Grau, Óscar, Alarcón-Martín, Emilio, Valero, Sergi, Alegret, Montserrat, Martín, Elvira, Martino-Adami, Pamela V., Ettcheto, Miren, Camins, Antonio, Vivas, Assumpta, Gomez-Chiari, Marta, Tejero, Miguel Ángel, Orellana, Adelina, Tárraga, Lluís, Marquié, Marta, Ramírez, Alfredo, Martí, Mercè, Pividori, María Isabel, Boada, Mercè, and Ruíz, Agustín

Published
2023
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2. Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort

Author

Marquié, Marta, Valero, Sergi, Martínez, Joan, Alarcón-Martín, Emilio, García-Sánchez, Ainhoa, de Rojas, Itziar, Castilla-Martí, Miguel, Castilla-Martí, Luis, Hernández, Isabel, Rosende-Roca, Maitée, Vargas, Liliana, Tartari, Juan Pablo, Esteban-De Antonio, Ester, Bojaryn, Urszula, Pytel, Vanesa, Narvaiza, Leire, Alegret, Montserrat, Ortega, Gemma, Espinosa, Ana, Sanabria, Ángela, Pérez-Cordón, Alba, Lleonart, Núria, Muñoz, Nathalia, Tárraga, Lluís, Ruiz, Agustín, and Boada, Mercè

Published
2022
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3. Macular vessel density in the superficial plexus is not associated to cerebrovascular damage in non‐demented individuals: data from the NORFACE cohort

Author

Marquié, Marta, primary, García‐Sánchez, Ainhoa, additional, Sotolongo‐Grau, Oscar, additional, Tartari, Juan Pablo, additional, Sanabria, Angela, additional, Esteban‐De Antonio, Ester, additional, Pérez, Alba, additional, Castilla‐Martí, Miguel, additional, Castilla‐Martí, Luis, additional, Martínez, Joan, additional, Alarcón‐Martín, Emilio, additional, Alegret, Montserrat, additional, Aguilera, Núria, additional, Vivas, Assumpta, additional, M, Gómez‐Chiari, additional, Escudero, José Miguel, additional, Tejero, Miguel Angel, additional, Tárraga, Lluís, additional, Ruiz, Agustin, additional, and Boada, Mercè, additional

Published
2023
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4. Macular vessel density in the superficial plexus is not a proxy of cerebrovascular damage in non-demented individuals: data from the NORFACE cohort.

Author

García-Sánchez, Ainhoa, Sotolongo-Grau, Oscar, Tartari, Juan Pablo, Sanabria, Ángela, Esteban - De Antonio, Ester, Pérez-Cordón, Alba, Alegret, Montserrat, Pytel, Vanesa, Martínez, Joan, Aguilera, Núria, de Rojas, Itziar, Cano, Amanda, García-González, Pablo, Puerta, Raquel, Olivé, Clàudia, Capdevila, Maria, García-Gutiérrez, Fernando, Vivas, Assumpta, Gómez-Chiari, Marta, and Giménez, Juan

Subjects
MULTIPLE regression analysis, CEREBRAL atrophy, OPTICAL coherence tomography, MILD cognitive impairment, MAGNETIC resonance imaging
Abstract

Introduction: Optical coherence tomography angiography (OCT-A) is a novel tool that allows the detection of retinal vascular changes. We investigated the association of macular vessel density (VD) in the superficial plexus assessed by OCT-A with measures of cerebrovascular pathology and atrophy quantified by brain magnetic resonance imaging (MRI) in non-demented individuals. Methods: Clinical, demographical, OCT-A, and brain MRI data from non-demented research participants were included. We analyzed the association of regional macular VD with brain vascular burden using the Fazekas scale assessed in a logistic regression analysis, and the volume of white matter hyperintensities (WMH) assessed in a multiple linear regression analysis. We also explored the associations of macular VD with hippocampal volume, ventricle volume and Alzheimer disease cortical signature (ADCS) thickness assessed in multiple linear regression analyses. All analyses were adjusted for age, sex, syndromic diagnosis and cardiovascular variables. Results: The study cohort comprised 188 participants: 89 with subjective cognitive decline and 99 with mild cognitive impairment. No significant association of regional macular VD with the Fazekas categories (all, p > 0.111) and WMH volume (all, p > 0.051) were detected. VD in the nasal quadrant was associated to hippocampal volume (p = 0.007), but no other associations of macular VD with brain atrophy measures were detected (all, p > 0.05). Discussion: Retinal vascular measures were not a proxy of cerebrovascular damage in non-demented individuals, while VD in the nasal quadrant was associated with hippocampal atrophy independently of the amyloid status. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Macular vessel density in the superficial plexus is not associated to cerebrospinal fluid core biomarkers for Alzheimer’s disease in individuals with mild cognitive impairment: The NORFACE cohort

Author

Marquié, Marta, primary, García-Sánchez, Ainhoa, additional, Alarcón-Martín, Emilio, additional, Martínez, Joan, additional, Castilla-Martí, Miguel, additional, Castilla-Martí, Luis, additional, Orellana, Adelina, additional, Montrreal, Laura, additional, de Rojas, Itziar, additional, García-González, Pablo, additional, Puerta, Raquel, additional, Olivé, Clàudia, additional, Cano, Amanda, additional, Hernández, Isabel, additional, Rosende-Roca, Maitée, additional, Vargas, Liliana, additional, Tartari, Juan Pablo, additional, Esteban-De Antonio, Ester, additional, Bojaryn, Urszula, additional, Ricciardi, Mario, additional, Ariton, Diana M., additional, Pytel, Vanesa, additional, Alegret, Montserrat, additional, Ortega, Gemma, additional, Espinosa, Ana, additional, Pérez-Cordón, Alba, additional, Sanabria, Ángela, additional, Muñoz, Nathalia, additional, Lleonart, Núria, additional, Aguilera, Núria, additional, Tárraga, Lluís, additional, Valero, Sergi, additional, Ruiz, Agustín, additional, and Boada, Mercè, additional

Published
2023
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6. The Synergic Effect of AT(N) Profiles and Depression on the Risk of Conversion to Dementia in Patients with Mild Cognitive Impairment

Author

Marquié, Marta, primary, García-Gutiérrez, Fernando, additional, Orellana, Adelina, additional, Montrreal, Laura, additional, de Rojas, Itziar, additional, García-González, Pablo, additional, Puerta, Raquel, additional, Olivé, Clàudia, additional, Cano, Amanda, additional, Hernández, Isabel, additional, Rosende-Roca, Maitée, additional, Vargas, Liliana, additional, Tartari, Juan Pablo, additional, Esteban-De Antonio, Ester, additional, Bojaryn, Urszula, additional, Ricciardi, Mario, additional, Ariton, Diana M., additional, Pytel, Vanesa, additional, Alegret, Montserrat, additional, Ortega, Gemma, additional, Espinosa, Ana, additional, Pérez-Cordón, Alba, additional, Sanabria, Ángela, additional, Muñoz, Nathalia, additional, Lleonart, Núria, additional, Aguilera, Núria, additional, García-Sánchez, Ainhoa, additional, Alarcón-Martín, Emilio, additional, Tárraga, Lluís, additional, Ruiz, Agustín, additional, Boada, Mercè, additional, and Valero, Sergi, additional

Published
2023
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7. Extracellular vesicles, the emerging mirrors of brain physiopathology

Author

Cano, Amanda, primary, Ettcheto, Miren, additional, Bernuz, Mireia, additional, Puerta, Raquel, additional, Esteban de Antonio, Ester, additional, Sánchez-López, Elena, additional, Souto, Eliana B., additional, Camins, Antonio, additional, Martí, Mercè, additional, Pividori, María Isabel, additional, Boada, Mercè, additional, and Ruiz, Agustín, additional

Published
2023
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8. Additional file 1 of Plasma extracellular vesicles reveal early molecular differences in amyloid positive patients with early-onset mild cognitive impairment

Author

Cano, Amanda, Esteban-de-Antonio, Ester, Bernuz, Mireia, Puerta, Raquel, García-González, Pablo, de Rojas, Itziar, Olivé, Claudia, Pérez-Cordón, Alba, Montrreal, Laura, Núñez-Llaves, Raúl, Sotolongo-Grau, Óscar, Alarcón-Martín, Emilio, Valero, Sergi, Alegret, Montserrat, Martín, Elvira, Martino-Adami, Pamela V., Ettcheto, Miren, Camins, Antonio, Vivas, Assumpta, Gomez-Chiari, Marta, Tejero, Miguel Ángel, Orellana, Adelina, Tárraga, Lluís, Marquié, Marta, Ramírez, Alfredo, Martí, Mercè, Pividori, María Isabel, Boada, Mercè, and Ruíz, Agustín

Abstract

Additional file 1: Figure S1. Neurology panel of Olink Proteomics (code 95801). Distribution of analytical measuring range, defined by the lower and upper limits of quantification (LLOQ-ULOQ), and normal plasma levels where data is available (dark blue bars) for 92 analytes. Figure S2. Inflammation panel of Olink Proteomics (code 95302). Distribution of analytical measuring range, defined by the limits of quantification LLOQ-ULOQ, for 90 out of 92 analytes. Table S1. List of proteins excluded/included in the study after the quality control analysis. Table S2. Demographics and biochemistry of the BIOFACE cohort. Table S3. Pearson correlations and effect between biomarkers in pEVs and most common parameters of AD analysis. Data ordered by R2. Displayed proteins above R2 > 0.3. Table S4. Pearson correlations and effect between biomarkers in CSF and most common parameters of AD analysis. Data ordered by R2. Displayed proteins above R2 > 0.3. Table S5. Pearson correlations and effect between biomarkers in plasma and most common parameters of AD analysis. Data ordered by R2. Displayed proteins above R2 > 0.3.

Published
2023
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9. Establishing In-House Cutoffs of CSF Alzheimer’s Disease Biomarkers for the AT(N) Stratification of the Alzheimer Center Barcelona Cohort

Author

Orellana, Adelina, primary, García-González, Pablo, additional, Valero, Sergi, additional, Montrreal, Laura, additional, de Rojas, Itziar, additional, Hernández, Isabel, additional, Rosende-Roca, Maitee, additional, Vargas, Liliana, additional, Tartari, Juan Pablo, additional, Esteban-De Antonio, Ester, additional, Bojaryn, Urszula, additional, Narvaiza, Leire, additional, Alarcón-Martín, Emilio, additional, Alegret, Montserrat, additional, Alcolea, Daniel, additional, Lleó, Alberto, additional, Tárraga, Lluís, additional, Pytel, Vanesa, additional, Cano, Amanda, additional, Marquié, Marta, additional, Boada, Mercè, additional, and Ruiz, Agustín, additional

Published
2022
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10. Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer’s type

Author

Martino Adami, Pamela V, primary, Orellana, Adelina, additional, García, Pablo, additional, Kleineidam, Luca, additional, Alarcón-Martín, Emilio, additional, Montrreal, Laura, additional, Aguilera, Nuria, additional, Espinosa, Ana, additional, Abdelnour, Carla, additional, Rosende-Roca, Maitee, additional, Pablo Tartari, Juan, additional, Vargas, Liliana, additional, Mauleón, Ana, additional, Esteban-De Antonio, Ester, additional, López-Cuevas, Rogelio, additional, Dalmasso, Maria Carolina, additional, Campos Martin, Rafael, additional, Parveen, Kayenat, additional, Andrade Fuentes, Victor M, additional, Amin, Najaf, additional, Ahmad, Shahzad, additional, Ikram, M Arfan, additional, Lewczuk, Piotr, additional, Kornhuber, Johannes, additional, Peters, Oliver, additional, Frölich, Lutz, additional, Rüther, Eckart, additional, Wiltfang, Jens, additional, Tarraga, Lluis, additional, Boada, Merce, additional, Maier, Wolfgang, additional, de Rojas, Itziar, additional, Cano, Amanda, additional, Sanabria, Angela, additional, Alegret, Montserrat, additional, Hernández, Isabel, additional, Marquié, Marta, additional, Valero, Sergi, additional, van Duijn, Cornelia M, additional, Wagner, Michael, additional, Jessen, Frank, additional, Schneider, Anja, additional, Sáez Goñi, María Eugenia, additional, González Pérez, Antonio, additional, Ruiz, Agustín, additional, and Ramírez, Alfredo, additional

Published
2022
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11. Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment

Author

Roberto, Natalia, primary, Portella, Maria J., additional, Marquié, Marta, additional, Alegret, Montserrat, additional, Hernández, Isabel, additional, Mauleón, Ana, additional, Rosende-Roca, Maitee, additional, Abdelnour, Carla, additional, Esteban de Antonio, Ester, additional, Tartari, Juan P., additional, Vargas, Liliana, additional, López-Cuevas, Rogelio, additional, Bojaryn, Urszula, additional, Espinosa, Ana, additional, Ortega, Gemma, additional, Pérez-Cordón, Alba, additional, Sanabria, Ángela, additional, Orellana, Adelina, additional, de Rojas, Itziar, additional, Moreno-Grau, Sonia, additional, Montrreal, Laura, additional, Alarcón-Martín, Emilio, additional, Ruíz, Agustín, additional, Tárraga, Lluís, additional, Boada, Mercè, additional, and Valero, Sergi, additional

Published
2021
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12. Comparison of automated CLEIA and manual ELISA immunoassays for CSF AD biomarkers: The Fundació ACE Biomarker Research Program (FACEBREP)

Author

Orellana, Adelina, primary, Valero, Sergi, additional, Abdelnour, Carla, additional, Montrreal, Laura, additional, de Rojas, Itziar, additional, Rosende‐Roca, Maitee, additional, Mauleon, Ana, additional, Vargas, Liliana, additional, Tartari, Juan Pablo, additional, Esteban‐De Antonio, Ester, additional, García‐González, Pablo, additional, Alarcón‐Martín, Emilio, additional, Alegret, Montserrat, additional, Alcolea, Daniel, additional, Lleó, Alberto, additional, Hernandez, Isabel, additional, Tarraga, Lluis, additional, Marquié, Marta, additional, and Boada, Mercè, additional

Published
2021
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13. BIOFACE: A Prospective Study of Risk Factors, Cognition, and Biomarkers in a Cohort of Individuals with Early-Onset Mild Cognitive Impairment. Study Rationale and Research Protocols.

Author

Esteban de Antonio, Ester, Pérez-Cordón, Alba, Gil, Silvia, Orellana, Adelina, Cano, Amanda, Alegret, Montserrat, Espinosa, Ana, Alarcón-Martín, Emilio, Valero, Sergi, Martínez, Joan, de Rojas, Itziar, Sotolongo-Grau, Óscar, Martín, Elvira, Vivas, Assumpta, Gomez-Chiari, Marta, Tejero, Miguel Ángel, Bernuz, Mireia, Tárraga, Lluis, Ruiz, Agustín, and Marquié, Marta

Subjects
*MILD cognitive impairment, *PROGNOSIS, *ALZHEIMER'S disease, *LONGITUDINAL method, *BIOMARKERS, *RESEARCH, *RESEARCH methodology, *COGNITION, *MAGNETIC resonance imaging, *MEDICAL cooperation, *EVALUATION research, *NEUROPSYCHOLOGICAL tests, *COMPARATIVE studies, *PSYCHOLOGICAL tests
Abstract

Background: Mild cognitive impairment (MCI) due to Alzheimer's disease (AD) diagnosis is based on cerebrospinal fluid (CSF) or neuroimaging biomarkers. Currently, non-invasive and inexpensive blood-based biomarkers are being investigated, such as neuronal-derived plasma exosomes (NPEs). Neuroinflammation and early vascular changes have been described in AD pathogenesis and can be traced in plasma and NPEs. However, they have not been studied in early onset MCI (EOMCI).Objective: To describe the rationale, design, and baseline characteristics of the participants from the BIOFACE cohort, a two-year observational study on EOMCI conducted at Fundació ACE. The study goal is to characterize the different phenotypes from a clinical, neuropsychological, and biomarker point of view and to investigate the CSF and plasma proteomics as well as the role of NPEs as early biomarkers of AD.Methods: Participants underwent extended neurological and neuropsychological batteries, multimodal biomarkers including brain MRI, blood, saliva, CSF, anthropometric, and neuro-ophthalmological examinations.Results: Ninety-seven patients with EOMCI were recruited. 59.8%were women. Mean age at symptom onset was 57 years; mean MMSE was 28. First degree and presenile family history of dementia was present in 60.8%and 15.5%, respectively. Depressive and anxiety disorders along with vascular risk factors were the most frequent comorbidities. 29%of participants were APOE ɛ4 carriers, and 67%showed a CSF normal ATN profile.Conclusion: BIOFACE is a two-year study of clinical, cognition, and biomarkers that will shed light on the physiopathology and the potential utility of plasma and NPEs as non-invasive early diagnostic and prognostic biomarkers in people younger than 65 years. [ABSTRACT FROM AUTHOR]

Published
2021
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