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Introduction: The use of the antifibrinolytic agent tranexamic acid has positive effects on bleeding control, but our knowledge is still limited regarding how fibrinolysis suppression changes the process of bone formation and the quality of bone. Because of the several side effects of systemic tranexamic acid, topical usage has been established in several procedures. This study aimed to investigate the effect of local tranexamic acid on vertebral fusion by using macroscopic, radiologic, and microscopic techniques. We also attempted to determine the safe dose range in case some doses had negative effects on fusion. Methods: Twenty-eight Wistar albino rats underwent intertransverse fusion. All rats were randomized into four groups: groups treated with local tranexamic acid doses of 1 mg/kg (D1), 10 mg/kg (D10), and 100 mg/kg (D100) and the control group with no drug (D0). At the end of the eighth week, all rats were sacrificed for evaluation in terms of palpation, mammography, and histopathologic analysis. Results: The manual palpation results presented with lower fusion rates in D10 and D100 groups than in the control group. Radiological examination results were significantly higher in the control group. The histopathologic examination revealed no significant differences between groups in the percent of new bone formation. Conclusions: Our results showed that local administration of tranexamic acid reduced the quality and stability of fusion without a delay in bone formation. However, doses of 1 mg/kg did not reduce the stability in the palpation test. Our findings suggest that 1 mg/kg dose is a critical threshold above which tranexamic acid reduced the bone healing process of fusion and that surgeons should consider the doses of local tranexamic acid during surgery.

This study presents a reduced version of the Perception of Family Support Scale (PFSS)--a measure of family support designed for research and clinical purposes--and examine construct validity, invariance, and reliability evidence for scores obtained from the instrument. Data collection occurred in 2019. Using exploratory and confirmatory factor analyses with college student samples from Australia, Brazil, Hong Kong, and Turkey (N = 1,256), we identified an oblique three-factor model corresponding to the original scale's internal structure (e.g. affective consistency, family maladaptation, and family autonomy). We also found configural, metric, and scalar invariance, good reliability coefficients, and significant relationships with distress (e.g. depression, anxiety, and stress) across the four studied countries. These results indicate good validity evidence for using the brief version of the PFSS. Applications of the PFSS and implications of the current results are discussed.

Abstract Cancer is a deadly disease that affects millions of people worldwide and is a source of great difficulty, stress, and trauma not only for patients but also for their caregivers. The physical and emotional suffering that patients experience by patients can lead their caregivers to cope with constant anxiety, sadness, and uncertainty. Moreover, during the cancer treatment process, caregivers must make a great effort to meet the needs of patients and support them. This situation may negatively affect the quality of life and psychological health of cancer patients’ caregivers and may lead them to experience trauma. The aim of this cross-sectional study was to examine posttraumatic growth’s relationship with age, the transformative power of suffering, and hope in family caregivers of cancer patients. Participants consisted of 314 Turkish family caregivers of cancer patients (73.2% women; M age = 39.89 years) selected by using convenience sampling method. Participants answered a data collection tool consisting of a demographic information form, the Posttraumatic Growth Inventory, Trait Hope Scale, and Transformative Power of Suffering Scale. Data were analyzed using descriptive statistics, the Pearson product-moment correlation coefficient analysis, simple mediation analysis, and moderated mediation analysis. The results of this study revealed that hope mediated the association between the transformative power of suffering and posttraumatic growth in family caregivers of cancer patients, whereas age moderated this relationship. Psychosocial support programs for cancer caregivers could benefit from incorporating interventions that explore the transformative potential of suffering and cultivate hope. Tailoring these interventions to address the specific needs of different age groups may enhance their effectiveness. Future researchers should investigate the factors associated with posttraumatic growth in caregivers across diverse cultures, age ranges, and cancer diagnoses.

Couple burnout has been linked to several negative consequences for both individuals and couples. Identifying the factors that predict couple burnout is essential for developing effective interventions to prevent or lessen its detrimental impact on marital relationships. The aim of this cross-sectional study was to investigate sociodemographic factors, relationship self-efficacy, happiness, and self-compassion as predictors of couple burnout in Turkish married individuals. A convenient sample of 401 married individuals completed a questionnaire that comprised a Personal Information Form, Couple Burnout Measure—Short Version, Relationship Self-Efficacy Scale, Self-Compassion Scale, and Single-Item Happiness Scale. The data were analyzed using descriptive statistics, Pearson’s product-moment correlation analysis, linear multiple regression analysis, and relative importance analyses. The results of this study suggest that being women, having a higher number of offspring, and lower levels of relationship self-efficacy, self-compassion, and happiness were significant positive predictors of couple burnout among married individuals. The type of marriage, monthly income, and duration of marriage were not significant predictors of couple burnout. Moreover, the results of the relative importance analyses consistently demonstrated that happiness was the strongest predictor of couple burnout among married individuals. The research findings demonstrate the multidimensional nature of couple burnout and provide a more nuanced understanding of its predictive factors. These results have potential implications for the development of evidence-based and targeted interventions in relationship education programs.

The aim of this study was to examine the severity of the symptoms of depression, anxiety, and stress in a nationally representative sample of secondary boarding school counselors and their association with sociodemographics, school counselor self-efficacy, self-esteem, happiness, and stressful life events. Participants consisted of 181 (52.5% women; M = 26.91) school counselors working at different secondary boarding schools across Turkey who completed the measures related to sociodemographics, happiness, self-esteem, school counselor self-efficacy, stressful life events, depression, anxiety, and stress. After confirming construct validity and reliability of the self-esteem, depression, anxiety, and stress scales, data were analyzed using descriptive statistics, Pearson product moment correlation analysis, and multivariate multiple regression analysis. The study results suggested that depression, anxiety, and stress symptoms are prevalent among school counselors, approximately 23% of whom experience at least moderate symptoms of depression and stress, and approximately 31% experience at least moderate symptoms of anxiety. Moreover, the results indicated that the most commonly experienced symptoms were dysphoria in depression, situational anxiety in anxiety, and impatience in stress among school counselors. This study also found that sociodemographic factors and school counselor self-efficacy were not associated with symptoms of depression, anxiety, and stress. However, higher levels of happiness and self-esteem and fewer stressful life events experienced within the past year consistently showed a negative association with exhibiting decreased symptoms of depression, anxiety, and stress among school counselors. Self-care activities focusing on increasing self-esteem and happiness and teaching skills to cope effectively with stressful life events may help to diminish the symptoms of depression, anxiety, and stress among secondary boarding school counselors.