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218 results on '"Ennishi, Daisuke"'

4. Oral azacitidine compared with standard therapy in patients with relapsed or refractory follicular helper T-cell lymphoma (ORACLE): an open-label randomised, phase 3 study

Author

Dupuis, Jehan, Bachy, Emmanuel, Morschhauser, Franck, Cartron, Guillaume, Fukuhara, Noriko, Daguindau, Nicolas, Casasnovas, René-Olivier, Snauwaert, Sylvia, Gressin, Remy, Fox, Christopher P, d’Amore, Francesco Annibale, Staber, Philipp B, Tournilhac, Olivier, Bouabdallah, Krimo, Thieblemont, Catherine, André, Marc, Rai, Shinya, Ennishi, Daisuke, Gkasiamis, Argyrios, Nishio, Mitsufumi, Fornecker, Luc-Matthieu, Delfau-Larue, Marie-Helene, Sako, Nouhoum, Mule, Sebastien, de Leval, Laurence, Gaulard, Philippe, Tsukasaki, Kunihiro, and Lemonnier, François

Published
2024
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5. Long-term outcomes of patients with primary intestinal follicular lymphoma managed with watch-and-wait strategy

Author

Iwamuro, Masaya, Tanaka, Takehiro, Ennishi, Daisuke, Matsueda, Kazuhiro, Yoshioka, Masao, Miyahara, Koji, Sakaguchi, Chihiro, Nishimura, Mamoru, Nagahara, Teruya, Mannami, Tomohiko, Takenaka, Ryuta, Oka, Shohei, Inoue, Masafumi, Takimoto, Hidetaka, Inaba, Tomoki, Kobayashi, Sayo, Toyokawa, Tatsuya, Tsugeno, Hirofumi, Suzuki, Seiyuu, Sawada, Sachiko, Tanaka, Shouichi, Tsuzuki, Takao, and Okada, Hiroyuki

Published
2023
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8. Distribution and clinical impact of molecular subtypes with dark zone signature of DLBCL in a Japanese real-world study

Author

Urata, Tomohiro, Naoi, Yusuke, Jiang, Aixiang, Boyle, Merrill, Sunami, Kazutaka, Imai, Toshi, Nawa, Yuichiro, Hiramatsu, Yasushi, Yamamoto, Kazuhiko, Fujii, Soichiro, Yoshida, Isao, Yano, Tomofumi, Chijimatsu, Ryota, Murakami, Hiroyuki, Ikeuchi, Kazuhiro, Kobayashi, Hiroki, Tani, Katsuma, Ujiie, Hideki, Inoue, Hirofumi, Tomida, Shuta, Yamamoto, Akira, Kondo, Takumi, Fujiwara, Hideaki, Asada, Noboru, Nishimori, Hisakazu, Fujii, Keiko, Fujii, Nobuharu, Matsuoka, Ken-ichi, Sawada, Keisuke, Momose, Shuji, Tamaru, Jun-ichi, Nishikori, Asami, Sato, Yasuharu, Yoshino, Tadashi, Maeda, Yoshinobu, Scott, David W., and Ennishi, Daisuke

Published
2023
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14. Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma

Author

Chijimatsu, Ryota, Kobayashi, Shogo, Takeda, Yu, Kitakaze, Masatoshi, Tatekawa, Shotaro, Arao, Yasuko, Nakayama, Mika, Tachibana, Naohiro, Saito, Taku, Ennishi, Daisuke, Tomida, Shuta, Sasaki, Kazuki, Yamada, Daisaku, Tomimaru, Yoshito, Takahashi, Hidenori, Okuzaki, Daisuke, Motooka, Daisuke, Ohshiro, Takahito, Taniguchi, Masateru, Suzuki, Yutaka, Ogawa, Kazuhiko, Mori, Masaki, Doki, Yuichiro, Eguchi, Hidetoshi, and Ishii, Hideshi

Published
2022
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15. Response to Imatinib in a Patient With Gastric Adenocarcinoma With KIT Q556_K558 In-Frame Deletion: A Case Report.

Author

Ninomiya, Kiichiro, Ennishi, Daisuke, Okamoto, Kunio, Ando, Midori, Nakamura, Satoko, Tomida, Shuta, Ayada, Yoshiyuki, Makimoto, Go, Ichihara, Eiki, Okita, Natsuko, Toyooka, Shinichi, Maeda, Yoshinobu, and Tabata, Masahiro

Subjects
*IMATINIB, *ADENOCARCINOMA
Abstract

Imatinib may be a useful targeted agent for patients with advanced gastric adenocarcinoma who have KIT mutations. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Combination of reduced post‐transplant cyclophosphamide and early tacrolimus initiation increases the incidence of chronic graft‐versus‐host disease in human leukocyte antigen‐haploidentical peripheral blood stem‐cell transplantation

Author

Terao, Toshiki, Kondo, Takumi, Nakamura, Makoto, Takasuka, Hiroki, Fujiwara, Hideaki, Asada, Noboru, Ennishi, Daisuke, Nishimori, Hisakazu, Fujii, Keiko, Fujii, Nobuharu, Maeda, Yoshinobu, and Matsuoka, Ken‐ichi

Published
2024
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18. Recent updates on treatment options for primary follicular lymphoma of the gastrointestinal tract.

Author

Iwamuro, Masaya, Tanaka, Takehiro, Ennishi, Daisuke, and Otsuka, Motoyuki

Subjects
FOLLICULAR lymphoma, BOWEL obstructions, GASTROINTESTINAL system, INTESTINAL tumors, LYMPHOMAS
Abstract

Background: Primary gastrointestinal follicular lymphoma is a subtype of follicular lymphoma that originates directly from the gastrointestinal tract. Pathologically, it exhibits substantial similarities with the secondary gastrointestinal involvement observed in nodal follicular lymphoma. However, primary gastrointestinal follicular lymphoma presents clinically distinct features, necessitating divergent considerations in treatment selection compared with nodal follicular lymphoma. Areas covered: This narrative review focused on recent articles (2018–2023) regarding the long-term prognosis and treatment options for gastrointestinal follicular lymphoma. In addition, a brief overview of gastrointestinal follicular lymphomas is provided. Expert opinion: Patients with primary gastrointestinal follicular lymphoma often present with a low tumor burden. Lymphoma lesions typically remain asymptomatic for several years or may undergo spontaneous regression without immediate treatment. Therefore, a 'watch and wait' approach is justified. Conversely, when large tumor masses are identified in the gastrointestinal tract, the potential for tumor bleeding or intestinal obstruction requires timely therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Collection efficiency and safety of large‐volume leukapheresis for the manufacturing of tisagenlecleucel

Author

Kitamura, Wataru, primary, Urata, Tomohiro, additional, Fujii, Keiko, additional, Fukumi, Takuya, additional, Ikeuchi, Kazuhiro, additional, Seike, Keisuke, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Matsuoka, Ken‐ichi, additional, Otsuka, Fumio, additional, Maeda, Yoshinobu, additional, and Fujii, Nobuharu, additional

Published
2024
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20. Clinical significance of gynecological examinations in long-term follow-ups

Author

Kamoi, Chihiro, primary, Fujii, Nobuharu, additional, Matsuoka, Hirofumi, additional, Takahashi, Kanayo, additional, Yamamoto, Akira, additional, Seike, Keisuke, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Matsuoka, Ken-Ichi, additional, and Maeda, Yoshinobu, additional

Published
2024
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21. Japanese phase Ib study of the oral PI3K-δ and -γ inhibitor duvelisib in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma

Author

Makita, Shinichi, primary, Ota, Shuichi, additional, Mishima, Yuko, additional, Usuki, Kensuke, additional, Ennishi, Daisuke, additional, Yanada, Masamitsu, additional, Fukuhara, Noriko, additional, Yamamoto, Ryusuke, additional, Takamine, Atsushi, additional, Nohara, Go, additional, and Izutsu, Koji, additional

Published
2023
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23. Author Correction: 5-aminolevulinic acid-mediated photodynamic therapy can target aggressive adult T cell leukemia/lymphoma resistant to conventional chemotherapy

Author

Sando, Yasuhisa, Matsuoka, Ken-ichi, Sumii, Yuichi, Kondo, Takumi, Ikegawa, Shuntaro, Sugiura, Hiroyuki, Nakamura, Makoto, Iwamoto, Miki, Meguri, Yusuke, Asada, Noboru, Ennishi, Daisuke, Nishimori, Hisakazu, Fujii, Keiko, Fujii, Nobuharu, Utsunomiya, Atae, Oka, Takashi, and Maeda, Yoshinobu

Published
2021
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25. Utility of Comprehensive Genomic Profiling for Precise Diagnosis of Pediatric-Type Diffuse High-Grade Glioma

Author

Makino, Keigo, Otani, Yoshihiro, Fujii, Kentaro, Ishida, Joji, Hirano, Shuichiro, Suruga, Yasuki, Washio, Kana, Nishida, Kenji, Yanai, Hiroyuki, Tomida, Shuta, Ennishi, Daisuke, and Date, Isao

Subjects
genome-wide DNA methylation, comprehensive genomic profiling, pediatric brain tumor, MYCN
Abstract

In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases.

Published
2023

26. Endoscopic manifestation of intestinal transplant-associated microangiopathy after stem cell transplantation.

Author

Iwamuro, Masaya, Ennishi, Daisuke, Fujii, Nobuharu, Matsuoka, Ken-ichi, Tanaka, Takehiro, Inokuchi, Toshihiro, Hiraoka, Sakiko, and Otsuka, Motoyuki

Subjects
*STEM cell transplantation, *GASTROINTESTINAL mucosa, *IRRITABLE colon, *SHORT bowel syndrome, *INTESTINES, *APPETITE loss, *GASTROINTESTINAL system
Abstract

Background: Endoscopic features of intestinal transplant-associated microangiopathy (iTAM) have not been comprehensively investigated. This study aimed to examine the endoscopic characteristics of patients diagnosed with iTAM. Methods: This retrospective analysis included 14 patients pathologically diagnosed with iTAM after stem cell transplantation for hematolymphoid neoplasms (n = 13) or thalassemia (n = 1). The sex, age at diagnosis, endoscopic features, and prognosis of each patient were assessed. Serological markers for diagnosing transplant-associated thrombotic microangiopathy were also evaluated. Results: The mean age at the time of iTAM diagnosis was 40.2 years. Patients diagnosed based on the pathognomonic pathological changes of iTAM presented with diverse symptoms at the times of endoscopic examinations, including diarrhea (n = 10), abdominal pain (n = 5), nausea (n = 4), appetite loss (n = 2), bloody stools (n = 2), abdominal discomfort (n = 1), and vomiting (n = 1). At the final follow-up, six patients survived, while eight patients succumbed, with a median time of 100.5 days (range: 52–247) post-diagnosis. Endoscopic manifestations included erythematous mucosa (n = 14), erosions (n = 13), ulcers (n = 9), mucosal edema (n = 9), granular mucosa (n = 9), and villous atrophy (n = 4). Erosions and/or ulcers were primarily observed in the colon (10/14, 71%), followed by the ileum (9/13, 69%), stomach (4/10, 40%), cecum (5/14, 36%), duodenum (3/10, 30%), rectum (4/14, 29%), and esophagus (1/10, 10%). Cytomegalovirus infection (n = 4) and graft-versus-host disease (n = 2) coexisted within the gastrointestinal tract. Patients had de novo prolonged or progressive thrombocytopenia (6/14, 43%), decreased hemoglobin concentration (4/14, 29%), reduced serum haptoglobin level (3/14, 21%), and a sudden and persistent increase in lactate dehydrogenase level (2/14, 14%). Peripheral blood samples from 12 patients were evaluated for schistocytes, with none exceeding 4%. Conclusions: This study provides a comprehensive exploration of the endoscopic characteristics of iTAM. Notably, all patients exhibited erythematous mucosa throughout the gastrointestinal tract, accompanied by prevalent manifestations, such as erosions (93%), ulcers (64%), mucosal edema (64%), granular mucosa (64%), and villous atrophy (29%). Because of the low positivity for serological markers of transplant-associated thrombotic microangiopathy in patients with iTAM, endoscopic evaluation and biopsy of these lesions are crucial, even in the absence of these serological features. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Evaluating the efficiency and safety of large‐volume leukapheresis using the Spectra Optia continuous mononuclear cell collection protocol for peripheral blood stem cell collection from healthy donors: A retrospective study

Author

Sumii, Yuichi, primary, Fujii, Keiko, additional, Kondo, Takumi, additional, Urata, Tomohiro, additional, Kimura, Maiko, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Matsuoka, Ken‐ichi, additional, Otsuka, Fumio, additional, Maeda, Yoshinobu, additional, and Fujii, Nobuharu, additional

Published
2023
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28. Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma

Author

Takata, Katsuyoshi, Chong, Lauren C., Ennishi, Daisuke, Aoki, Tomohiro, Li, Michael Yu, Thakur, Avinash, Healy, Shannon, Vigano, Elena, Dao, Tao, Kwon, Daniel, Duns, Gerben, Nielsen, Julie S., Ben-Neriah, Susana, Tse, Ethan, Hung, Stacy S., Boyle, Merrill, Mun, Sung Soo, Bourne, Christopher M., Woolcock, Bruce, Telenius, Adele, Kishida, Makoto, Rai, Shinya, Zhang, Allen W., Bashashati, Ali, Saberi, Saeed, DAntonio, Gianluca, Nelson, Brad H., Shah, Sohrab P., Hoodless, Pamela A., Melnick, Ari M., Gascoyne, Randy D., Connors, Joseph M., Scheinberg, David A., Beguelin, Wendy, Scott, David W., and Steidl, Christian

Subjects
Oncology, Experimental, Gene mutations -- Research, Immune response -- Genetic aspects, Non-Hodgkin's lymphomas -- Genetic aspects -- Care and treatment, Tumor antigens -- Genetic aspects, Cancer -- Research, Health care industry
Abstract

PRAME is a prominent member of the cancer testis antigen family of proteins, which triggers autologous T cell-mediated immune responses. Integrative genomic analysis in diffuse large B cell lymphoma (DLBCL) uncovered recurrent and highly focal deletions of 22q11.22, including the PRAME gene, which were associated with poor outcome. PRAME-deleted tumors showed cytotoxic T cell immune escape and were associated with cold tumor microenvironments. In addition, PRAME downmodulation was strongly associated with somatic EZH2 Y641 mutations in DLBCL. In turn, PRC2-regulated genes were repressed in isogenic PRAME-KO lymphoma cell lines, and PRAME was found to directly interact with EZH2 as a negative regulator. EZH2 inhibition with EPZ-6438 abrogated these extrinsic and intrinsic effects, leading to PRAME expression and microenvironment restoration in vivo. Our data highlight multiple functions of PRAME during lymphomagenesis and provide a preclinical rationale for synergistic therapies combining epigenetic reprogramming with PRAME-targeted therapies., Introduction The current treatment standard of combined immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) has achieved significant improvement in patient outcomes in diffuse large B cell lymphoma (DLBCL) [...]

Published
2022
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29. Efficient granulocyte collection method using high concentrations of medium molecular weight hydroxyethyl starch

Author

Kondo, Takumi, primary, Fujii, Keiko, additional, Fujii, Nobuharu, additional, Sumii, Yuichi, additional, Urata, Tomohiro, additional, Kimura, Maiko, additional, Matsuda, Masayuki, additional, Ikegawa, Shuntaro, additional, Washio, Kana, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Matsuoka, Ken‐ichi, additional, Otsuka, Fumio, additional, and Maeda, Yoshinobu, additional

Published
2023
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31. Genomic Profiling of a Case of Glioneuronal Tumor with Neuropil-like Islands

Author

Tsuboi, Nobushige, Ishida, Joji, Shimazu, Yosuke, Edaki, Hisanori, Uneda, Atsuhito, Otani, Yoshihiro, Fujii, Kentaro, Kurozumi, Kazuhiko, Ennishi, Daisuke, Yanai, Hiroyuki, and Date, Isao

Subjects
glioneuronal tumor with neuropil-like islands, genomic profiling
Abstract

Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully.

Published
2022

33. Hematopoietic stem cell–derived Tregs are essential for maintaining favorable B cell lymphopoiesis following posttransplant cyclophosphamide

Author

Sumii, Yuichi, primary, Kondo, Takumi, additional, Ikegawa, Shuntaro, additional, Fukumi, Takuya, additional, Iwamoto, Miki, additional, Nishimura, Midori Filiz, additional, Sugiura, Hiroyuki, additional, Sando, Yasuhisa, additional, Nakamura, Makoto, additional, Meguri, Yusuke, additional, Matsushita, Takashi, additional, Tanimine, Naoki, additional, Kimura, Maiko, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Maeda, Yoshinobu, additional, and Matsuoka, Ken-ichi, additional

Published
2023
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34. Supplementary Table S11 and 15 from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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35. Supplementary Table S1-3 from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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36. Supplementary Table S8-9 from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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37. Supplementary Table S12-14 from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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38. Supplementary Table S5 from CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas

Author

Jiang, Yanwen, primary, Ortega-Molina, Ana, primary, Geng, Huimin, primary, Ying, Hsia-Yuan, primary, Hatzi, Katerina, primary, Parsa, Sara, primary, McNally, Dylan, primary, Wang, Ling, primary, Doane, Ashley S., primary, Agirre, Xabier, primary, Teater, Matt, primary, Meydan, Cem, primary, Li, Zhuoning, primary, Poloway, David, primary, Wang, Shenqiu, primary, Ennishi, Daisuke, primary, Scott, David W., primary, Stengel, Kristy R., primary, Kranz, Janice E., primary, Holson, Edward, primary, Sharma, Sneh, primary, Young, James W., primary, Chu, Chi-Shuen, primary, Roeder, Robert G., primary, Shaknovich, Rita, primary, Hiebert, Scott W., primary, Gascoyne, Randy D., primary, Tam, Wayne, primary, Elemento, Olivier, primary, Wendel, Hans-Guido, primary, and Melnick, Ari M., primary

Published
2023
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39. Data from CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas

Author

Jiang, Yanwen, primary, Ortega-Molina, Ana, primary, Geng, Huimin, primary, Ying, Hsia-Yuan, primary, Hatzi, Katerina, primary, Parsa, Sara, primary, McNally, Dylan, primary, Wang, Ling, primary, Doane, Ashley S., primary, Agirre, Xabier, primary, Teater, Matt, primary, Meydan, Cem, primary, Li, Zhuoning, primary, Poloway, David, primary, Wang, Shenqiu, primary, Ennishi, Daisuke, primary, Scott, David W., primary, Stengel, Kristy R., primary, Kranz, Janice E., primary, Holson, Edward, primary, Sharma, Sneh, primary, Young, James W., primary, Chu, Chi-Shuen, primary, Roeder, Robert G., primary, Shaknovich, Rita, primary, Hiebert, Scott W., primary, Gascoyne, Randy D., primary, Tam, Wayne, primary, Elemento, Olivier, primary, Wendel, Hans-Guido, primary, and Melnick, Ari M., primary

Published
2023
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40. Supplementary Methods and Figures from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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41. Supplementary Table S10 from Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Author

Ennishi, Daisuke, primary, Takata, Katsuyoshi, primary, Béguelin, Wendy, primary, Duns, Gerben, primary, Mottok, Anja, primary, Farinha, Pedro, primary, Bashashati, Ali, primary, Saberi, Saeed, primary, Boyle, Merrill, primary, Meissner, Barbara, primary, Ben-Neriah, Susana, primary, Woolcock, Bruce W., primary, Telenius, Adèle, primary, Lai, Daniel, primary, Teater, Matt, primary, Kridel, Robert, primary, Savage, Kerry J., primary, Sehn, Laurie H., primary, Morin, Ryan D., primary, Marra, Marco A., primary, Shah, Sohrab P., primary, Connors, Joseph M., primary, Gascoyne, Randy D., primary, Scott, David W., primary, Melnick, Ari M., primary, and Steidl, Christian, primary

Published
2023
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42. Supplementary Figures S1 - S14 from CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas

Author

Jiang, Yanwen, primary, Ortega-Molina, Ana, primary, Geng, Huimin, primary, Ying, Hsia-Yuan, primary, Hatzi, Katerina, primary, Parsa, Sara, primary, McNally, Dylan, primary, Wang, Ling, primary, Doane, Ashley S., primary, Agirre, Xabier, primary, Teater, Matt, primary, Meydan, Cem, primary, Li, Zhuoning, primary, Poloway, David, primary, Wang, Shenqiu, primary, Ennishi, Daisuke, primary, Scott, David W., primary, Stengel, Kristy R., primary, Kranz, Janice E., primary, Holson, Edward, primary, Sharma, Sneh, primary, Young, James W., primary, Chu, Chi-Shuen, primary, Roeder, Robert G., primary, Shaknovich, Rita, primary, Hiebert, Scott W., primary, Gascoyne, Randy D., primary, Tam, Wayne, primary, Elemento, Olivier, primary, Wendel, Hans-Guido, primary, and Melnick, Ari M., primary

Published
2023
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43. Supplementary Data from An Imaging-Based Rapid Evaluation Method for Complement-Dependent Cytotoxicity Discriminated Clinical Response to Rituximab-Containing Chemotherapy

Author

Mishima, Yuji, primary, Sugimura, Natsuhiko, primary, Matsumoto-Mishima, Yuko, primary, Terui, Yasuhito, primary, Takeuchi, Kengo, primary, Asai, Suzuka, primary, Ennishi, Daisuke, primary, Asai, Hiroaki, primary, Yokoyama, Masahiro, primary, Kojima, Kiyotsugu, primary, and Hatake, Kiyohiko, primary

Published
2023
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44. Bone marrow microenvironment disruption and sustained inflammation with prolonged haematologic toxicity after CAR T‐cell therapy

Author

Kitamura, Wataru, primary, Asada, Noboru, additional, Naoi, Yusuke, additional, Abe, Masaya, additional, Fujiwara, Hideaki, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Fujii, Nobuharu, additional, Matsuoka, Ken‐ichi, additional, Yoshino, Tadashi, additional, and Maeda, Yoshinobu, additional

Published
2023
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45. Hematopoietic stem cell-derived Tregs are essential for maintaining favorable B cell lymphopoiesis following posttransplant cyclophosphamide

Author

Sumii, Yuichi, Kondo, Takumi, Ikegawa, Shuntaro, Fukumi, Takuya, Iwamoto, Miki, Nishimura, Midori Filiz, Sugiura, Hiroyuki, Sando, Yasuhisa, Nakamura, Makoto, Meguri, Yusuke, Matsushita, Takashi, Tanimine, Naoki, Kimura, Maiko, Asada, Noboru, Ennishi, Daisuke, Maeda, Yoshinobu, Matsuoka, Ken-Ichi, Sumii, Yuichi, Kondo, Takumi, Ikegawa, Shuntaro, Fukumi, Takuya, Iwamoto, Miki, Nishimura, Midori Filiz, Sugiura, Hiroyuki, Sando, Yasuhisa, Nakamura, Makoto, Meguri, Yusuke, Matsushita, Takashi, Tanimine, Naoki, Kimura, Maiko, Asada, Noboru, Ennishi, Daisuke, Maeda, Yoshinobu, and Matsuoka, Ken-Ichi

Abstract

Posttransplant cyclophosphamide (PTCy) is associated with a low incidence of chronic graft -versus-host disease (cGVHD) following hematopoietic stem cell (HSC) transplantation. Previous studies have shown the important roles of B cell immunity in cGVHD development. Here, we investigated the long-term reconstitution of B lymphopoiesis after PTCy using murine models. We first demonstrated that the immune homeostatic abnormality leading to cGVHD is characterized by an initial increase in effector T cells in the bone marrow and subsequent B and Treg cytopenia. PTCy, but not cyclosporine A or rapamycin, inhibits the initial alloreactive T cell response, which restores intra-bone marrow B lymphogenesis with a concomitant vigorous increase in Tregs. This leads to profound changes in posttransplant B cell homeostasis, including decreased B cell activating factors, increased transitional and regulatory B cells, and decreased germinal center B cells. To identify the cells responsible for PTCy-induced B cell tolerance, we selectively depleted Treg populations that were graft or HSC derived using DEREG mice. Deletion of either Treg population without PTCy resulted in critical B cytopenia. PTCy rescued B lymphopoiesis from graft-derived Treg deletion. In contrast, the negative effect of HSC-derived Treg deletion could not be overcome by PTCy, indicating that HSC-derived Tregs are essential for maintaining favorable B lymphopoiesis following PTCy. These findings define the mechanisms by which PTCy restores homeostasis of the B cell lineage and reestablishes immune tolerance.

Published
2023

46. Efficient granulocyte collection method using high concentrations of medium molecular weight hydroxyethyl starch

Author

Kondo, Takumi, Fujii, Keiko, Fujii, Nobuharu, Sumii, Yuichi, Urata, Tomohiro, Kimura, Maiko, Matsuda, Masayuki, Ikegawa, Shuntaro, Washio, Kana, Fujiwara, Hideaki, Asada, Noboru, Ennishi, Daisuke, Nishimori, Hisakazu, Matsuoka, Ken‐ichi, Otsuka, Fumio, Maeda, Yoshinobu, Kondo, Takumi, Fujii, Keiko, Fujii, Nobuharu, Sumii, Yuichi, Urata, Tomohiro, Kimura, Maiko, Matsuda, Masayuki, Ikegawa, Shuntaro, Washio, Kana, Fujiwara, Hideaki, Asada, Noboru, Ennishi, Daisuke, Nishimori, Hisakazu, Matsuoka, Ken‐ichi, Otsuka, Fumio, and Maeda, Yoshinobu

Abstract

Background: Granulocyte transfusion therapy is a rational therapeutic option for patients with prolonged, severe neutropenia. Although high molecular weight hydroxyethyl starch (hHES) facilitates the separation of red blood cells during granulocyte collection, renal dysfunction has been noted as a potential side effect. HES130/0.4 (Voluven®) is a medium molecular weight HES (mHES) with superior safety profiles compared to hHES. Although HES130/0.4 is reportedly effective in the collection of granulocytes, we lack studies comparing the efficiency of granulocyte collection using HES130/0.4 and hHES. Study Design and Methods: We retrospectively collected the data from 60 consecutive apheresis procedures performed on 40 healthy donors at the Okayama University Hospital between July 2013 and December 2021. All procedures were performed using the Spectra Optia system. Based on the HES130/0.4 concentration in the separation chamber, granulocyte collection methods using HES130/0.4 were classified into m0.46, m0.44, m0.37, and m0.8 groups. We used HES130/0.4 and hHES groups to compare the various sample collection methods. Results: The median granulocyte collection efficiency (CE) was approximately 24.0% and 28.1% in the m0.8 and hHES groups, respectively, which were significantly higher than those in the m0.46, m0.44, and m0.37 groups. One month following granulocyte collection with HES130/0.4, no significant changes were observed in serum creatinine levels compared to those before the donation. Conclusion: Therefore, we propose a granulocyte collection approach employing HES130/0.4, which is comparable to the use of hHES in terms of the granulocyte CE. A high concentration of HES130/0.4 in the separation chamber was considered crucial for granulocyte collection.

Published
2023

47. Prolonged Cytopenia after CAR-T Cell Therapy Is Associated with BM Niche Disruption and a Sustained Inflammation in the BM

Author

Kitamura, Wataru, primary, Asada, Noboru, additional, Naoi, Yusuke, additional, Fujiwara, Hideaki, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Fujii, Nobuharu, additional, Matsuoka, Ken-ichi, additional, Yoshino, Tadashi, additional, and Maeda, Yoshinobu, additional

Published
2023
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48. Pre-infusion factors predicting early failure after tisagenlecleucel for patients with relapsed/refractory diffuse large B-cell lymphoma: A single institute retrospective analysis

Author

Kitamura, Wataru, primary, Fujii, Nobuharu, additional, Kamoi, Chihiro, additional, Urata, Tomohiro, additional, Kobayashi, Hiroki, additional, Yamamoto, Akira, additional, Seike, Keisuke, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Matsuoka, Ken-ichi, additional, and Maeda, Yoshinobu, additional

Published
2023
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49. Early initiation of low-dose gilteritinib maintenance improves posttransplant outcomes in patients with R/R FLT3mut AML

Author

Terao, Toshiki, primary, Matsuoka, Ken-ichi, additional, Ueda, Hiroko, additional, Matsumura, Akifumi, additional, Matsubara, Chisato, additional, Kondo, Kaho, additional, Kondo, Takumi, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Fujii, Nobuharu, additional, and Maeda, Yoshinobu, additional

Published
2022
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50. Association between early corticosteroid administration and long-term survival in non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation

Author

Kambara, Yui, primary, Fujii, Nobuharu, additional, Usui, Yoshiaki, additional, Yamamoto, Akira, additional, Higo, Hisao, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Matsuoka, Ken-ichi, additional, and Maeda, Yoshinobu, additional

Published
2022
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