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3. Time From Distress Call to Percutaneous Coronary Intervention and Outcomes in Myocardial Infarction

Author

Mills, Elisabeth Helen Anna, Møller, Amalie Lykkemark, Engstrøm, Thomas, Folke, Fredrik, Pedersen, Frants, Køber, Lars, Gnesin, Filip, Zylyftari, Nertila, Blomberg, Stig Nikolaj Fasmer, Kragholm, Kristian, Gislason, Gunnar, Jensen, Britta, Lippert, Freddy, Kragelund, Charlotte, Christensen, Helle Collatz, Andersen, Mikkel Porsborg, and Torp-Pedersen, Christian

Published
2024
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4. A Systematic Approach to the Evaluation of the Coronary Microcirculation Using Bolus Thermodilution: CATH CMD

Author

Collet, Carlos, Yong, Andy, Munhoz, Daniel, Akasaka, Takashi, Berry, Colin, Blair, John E.A., Collison, Damien, Engstrøm, Thomas, Escaned, Javier, Fearon, William F., Ford, Tom, Gori, Tommaso, Koo, Bon-Kwon, Low, Adrian F, Miner, Steve, Ng, Martin K.C., Mizukami, Takuya, Shimokawa, Hiroki, Smilowitz, Nathaniel R., Sutton, Nadia R., Svanerud, Johan, Tremmel, Jennifer A., Warisawa, Takayuki, West, Nick E.J., and Ali, Ziad A.

Published
2024
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5. Effects of alirocumab on endothelial function and coronary atherosclerosis in myocardial infarction: A PACMAN-AMI randomized clinical trial substudy

Author

Rexhaj, Emrush, Bär, Sarah, Soria, Rodrigo, Ueki, Yasushi, Häner, Jonas D., Otsuka, Tatsuhiko, Kavaliauskaite, Raminta, Siontis, George CM., Stortecky, Stefan, Shibutani, Hiroki, Spirk, David, Engstrøm, Thomas, Lang, Irene, Morf, Laura, Ambühl, Maria, Windecker, Stephan, Losdat, Sylvain, Koskinas, Konstantinos C., and Räber, Lorenz

Published
2024
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7. The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease

Author

Kofoed, Klaus F., Nordestgaard, Børge, Køber, Lars V., Kühl, J. Tobias, Fuchs, Andreas, Sigvardsen, Per E., Sørgaard, Mathias, de Knegt, Martina C., Norsk, Jakob, Frestad, Daria, Mejdahl, Mads, Elming, Marie, Sørensen, Samuel Kiil, Hindsøe, Louise, Thomsen, Anna Foged, Udholm, Patricia Martens, Pihl, Christian, Nilsson, Julia, Byrne, Christina, Knudsen, Andreas Dehlbæk, Haugen, Morten, Windfeld-Mathiasen, Josefine, Laura Wiegandt, Yaffah Tamar, Pham, Michael H.C., Ballegaard, Christian, Arnaa, Kirsten, Møller, Christina, Thrysøe, Kirsten, Linde, Jesper J., Hove, Jens D., Jensen, Gorm B., Kelbæk, Henning, Nielsen, Walter, Trysøe, Kirsten, Bock-Pedersen, Tina, Hansen, Bettina, Kløvgaard, Lene, Holmvang, Lene, Engstrøm, Thomas, Helquist, Steffen, Jørgensen, Erik, Petersen, Frans, Saunamaki, Kari, Clemmensen, Peter, Høfsten, Dan E., Sadjadieh, Golnaz, Laursen, Peter Nørkjær, Petersen, Christian Torp, Hansen, Peter Riis, Gislason, Gunnar, Abildgaard, Ulrik, Jensen, Jan Skov, Galatius, Søren, Fritz-Hansen, Thomas, Bech, Jan, Wachtell, Christian, Madsen, Jan Kyst, Smedegaard, Lærke, Özcan, Cengiz, Heitmann, Merete, Svendsen, Ida Hastrup, Nielsen, Olav Wendelboe, Kristiansen, Ole, Bjerre, Andreas Fabricius, Dixen, Ulrik, Madsen, Johnny Koertz, Fornitz, Gitte Gleerup, Raymond, Ilan, Abdulla, Jawdat, Lyngbæk, Stig, Steffensen, Rolf, Jurlander, Birgit, Kragelund, Charlotte, Dominguez, Helena, Schou, Morten, Elming, Hanne, Therkelsen, Susette, Jensen, Andreas K., Hansen, Peter R., and Nordestgaard, Børge G.

Published
2024
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9. Rationale and design of the pullback pressure gradient (PPG) global registry

Author

Munhoz, Daniel, Collet, Carlos, Mizukami, Takuya, Yong, Andy, Leone, Antonio Maria, Eftekhari, Ashkan, Ko, Brian, da Costa, Bruno R., Berry, Colin, Collison, Damien, Perera, Divaka, Christiansen, Evald Høj, Rivero, Fernando, Zimmermann, Frederik M., Ando, Hirohiko, Matsuo, Hitoshi, Nakayama, Masafumi, Escaned, Javier, Sonck, Jeroen, Sakai, Koshiro, Adjedj, Julien, Desta, Liyew, van Nunen, Lokien X., West, Nick E.J., Fournier, Stephane, Storozhenko, Tatyana, Amano, Tetsuya, Engstrøm, Thomas, Johnson, Thomas, Shinke, Toshiro, Biscaglia, Simone, Fearon, William F., Ali, Ziad, De Bruyne, Bernard, and Johnson, Nils P.

Published
2023
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10. Concomitant Coronary Atheroma Regression and Stabilization in Response to Lipid-Lowering Therapy

Author

Biccirè, Flavio G., Häner, Jonas, Losdat, Sylvain, Ueki, Yasushi, Shibutani, Hiroki, Otsuka, Tatsuhiko, Kakizaki, Ryota, Hofbauer, Thomas M., van Geuns, Robert-Jan, Stortecky, Stefan, Siontis, George C.M., Bär, Sarah, Lønborg, Jacob, Heg, Dik, Kaiser, Christoph, Spirk, David, Daemen, Joost, Iglesias, Juan F., Windecker, Stephan, Engstrøm, Thomas, Lang, Irene, Koskinas, Konstantinos C., and Räber, Lorenz

Published
2023
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11. Impact of Post-PCI FFR Stratified by Coronary Artery

Author

Collet, Carlos, Johnson, Nils P., Mizukami, Takuya, Fearon, William F., Berry, Colin, Sonck, Jeroen, Collison, Damien, Koo, Bon-Kwon, Meneveau, Nicolas, Agarwal, Shiv Kumar, Uretsky, Barry, Hakeem, Abdul, Doh, Joon-Hyung, Da Costa, Bruno R., Oldroyd, Keith G., Leipsic, Jonathon A., Morbiducci, Umberto, Taylor, Charles, Ko, Brian, Tonino, Pim A.L., Perera, Divaka, Shinke, Toshiro, Chiastra, Claudio, Sposito, Andrei C., Leone, Antonio Maria, Muller, Olivier, Fournier, Stephane, Matsuo, Hitoshi, Adjedj, Julien, Amabile, Nicolas, Piróth, Zsolt, Alfonso, Fernando, Rivero, Fernando, Ahn, Jung-Min, Toth, Gabor G., Ihdayhid, Abdul, West, Nick E.J., Amano, Tetsuya, Wyffels, Eric, Munhoz, Daniel, Belmonte, Marta, Ohashi, Hirofumi, Sakai, Koshiro, Gallinoro, Emanuele, Barbato, Emanuele, Engstrøm, Thomas, Escaned, Javier, Ali, Ziad A., Kern, Morton J., Pijls, Nico H.J., Jüni, Peter, and De Bruyne, Bernard

Published
2023
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12. Optimal timing of influenza vaccination among patients with acute myocardial infarction – Findings from the IAMI trial

Author

Akhtar, Zubair, Götberg, Matthias, Erlinge, David, Christiansen, Evald H., Oldroyd, Keith G., Motovska, Zuzana, Erglis, Andrejs, Hlinomaz, Ota, Jakobsen, Lars, Engstrøm, Thomas, Jensen, Lisette O., Fallesen, Christian O., Jensen, Svend E., Angerås, Oskar, Calais, Fredrik, Kåregren, Amra, Lauermann, Jörg, Mokhtari, Arash, Nilsson, Johan, Persson, Jonas, Islam, Abu K.M.M., Rahman, Afzalur, Malik, Fazila, Choudhury, Sohel, Collier, Timothy, Pocock, Stuart J., Pernow, John, MacIntyre, Chandini R., and Fröbert, Ole

Published
2023
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13. Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation – the third nordic aortic valve intervention trial – NOTION-3

Author

Sabbah, Muhammad, Veien, Karsten, Niemela, Matti, Freeman, Phillip, Linder, Rickard, Ioanes, Dan, Terkelsen, Christian Juhl, Kajander, Olli A., Koul, Sasha, Savontaus, Mikko, Karjalainen, Pasi, Erglis, Andrejs, Minkkinen, Mikko, Jørgensen, Troels, Sondergaard, Lars, De Backer, Ole, Engstrøm, Thomas, and Lønborg, Jacob

Published
2023
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14. Clinical impact of influenza vaccination after ST- and non-ST-segment elevation myocardial infarction - insights from the IAMI trial

Author

Fröbert, Ole, Götberg, Matthias, Erlinge, David, Akhtar, Zubair, Christiansen, Evald H., MacIntyre, Chandini R., Oldroyd, Keith G., Motovska, Zuzana, Erglis, Andrejs, Moer, Rasmus, Hlinomaz, Ota, Jakobsen, Lars, Engstrøm, Thomas, Jensen, Lisette O., Fallesen, Christian O., Jensen, Svend E, Angerås, Oskar, Calais, Fredrik, Kåregren, Amra, Lauermann, Jörg, Mokhtari, Arash, Nilsson, Johan, Persson, Jonas, Stalby, Per, Islam, Abu K.M.M., Rahman, Afzalur, Malik, Fazila, Choudhury, Sohel, Collier, Timothy, Pocock, Stuart J., and Pernow, John

Published
2023
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15. Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes

Author

Collet, Carlos, primary, Munhoz, Daniel, additional, Mizukami, Takuya, additional, Sonck, Jeroen, additional, Matsuo, Hitoshi, additional, Shinke, Toshiro, additional, Ando, Hirohiko, additional, Ko, Brian, additional, Biscaglia, Simone, additional, Rivero, Fernando, additional, Engstrøm, Thomas, additional, Arslani, Ketina, additional, Leone, Antonio Maria, additional, van Nunen, Lokien X., additional, Fearon, William F., additional, Christiansen, Evald Høj, additional, Fournier, Stephane, additional, Desta, Liyew, additional, Yong, Andy, additional, Adjej, Julien, additional, Escaned, Javier, additional, Nakayama, Masafumi, additional, Eftekhari, Ashkan, additional, Zimmermann, Frederik M., additional, Sakai, Koshiro, additional, Storozhenko, Tatyana, additional, da Costa, Bruno R., additional, Campo, Gianluca, additional, West, Nick E.J., additional, De Potter, Tom, additional, Heggermont, Ward, additional, Buytaert, Dimitri, additional, Bartunek, Jozef, additional, Berry, Colin, additional, Collison, Damien, additional, Johnson, Thomas, additional, Amano, Tetsuya, additional, Perera, Divaka, additional, Jeremias, Allen, additional, Ali, Ziad, additional, Pijls, Nico H.J., additional, De Bruyne, Bernard, additional, and Johnson, Nils P., additional

Published
2024
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16. Effect of Alirocumab on Carotid Inflammation by [18F]FDG PET in Patients with Acute Myocardial Infarction

Author

Bang, Lia E., primary, Jensen, Jacob Kildevang, additional, Räber, Lorenz, additional, Koskinas, Konstantinos C., additional, Bär, Sarah, additional, Losdat, Sylvain, additional, Matter, Christian M., additional, Lonborg, Jacob, additional, Radu Juul Jensen, Maria D., additional, Kjaer, Andreas, additional, Engstrøm, Thomas, additional, and Ripa, Rasmus Sejersten, additional

Published
2024
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18. The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease

Author

de Knegt, Martina C., primary, Linde, Jesper J., additional, Sigvardsen, Per E., additional, Engstrøm, Thomas, additional, Fuchs, Andreas, additional, Jensen, Andreas K., additional, Elming, Hanne, additional, Kühl, J. Tobias, additional, Hansen, Peter R., additional, Høfsten, Dan E., additional, Kelbæk, Henning, additional, Nordestgaard, Børge G., additional, Hove, Jens D., additional, Køber, Lars V., additional, Kofoed, Klaus F., additional, Nordestgaard, Børge, additional, Sørgaard, Mathias, additional, de Knegt, Martina C., additional, Norsk, Jakob, additional, Frestad, Daria, additional, Mejdahl, Mads, additional, Elming, Marie, additional, Sørensen, Samuel Kiil, additional, Hindsøe, Louise, additional, Thomsen, Anna Foged, additional, Udholm, Patricia Martens, additional, Pihl, Christian, additional, Nilsson, Julia, additional, Byrne, Christina, additional, Knudsen, Andreas Dehlbæk, additional, Haugen, Morten, additional, Windfeld-Mathiasen, Josefine, additional, Laura Wiegandt, Yaffah Tamar, additional, Pham, Michael H.C., additional, Ballegaard, Christian, additional, Arnaa, Kirsten, additional, Møller, Christina, additional, Thrysøe, Kirsten, additional, Jensen, Gorm B., additional, Nielsen, Walter, additional, Trysøe, Kirsten, additional, Bock-Pedersen, Tina, additional, Hansen, Bettina, additional, Kløvgaard, Lene, additional, Holmvang, Lene, additional, Helquist, Steffen, additional, Jørgensen, Erik, additional, Petersen, Frans, additional, Saunamaki, Kari, additional, Clemmensen, Peter, additional, Sadjadieh, Golnaz, additional, Laursen, Peter Nørkjær, additional, Petersen, Christian Torp, additional, Hansen, Peter Riis, additional, Gislason, Gunnar, additional, Abildgaard, Ulrik, additional, Jensen, Jan Skov, additional, Galatius, Søren, additional, Fritz-Hansen, Thomas, additional, Bech, Jan, additional, Wachtell, Christian, additional, Madsen, Jan Kyst, additional, Smedegaard, Lærke, additional, Özcan, Cengiz, additional, Heitmann, Merete, additional, Svendsen, Ida Hastrup, additional, Nielsen, Olav Wendelboe, additional, Kristiansen, Ole, additional, Bjerre, Andreas Fabricius, additional, Dixen, Ulrik, additional, Madsen, Johnny Koertz, additional, Fornitz, Gitte Gleerup, additional, Raymond, Ilan, additional, Abdulla, Jawdat, additional, Lyngbæk, Stig, additional, Steffensen, Rolf, additional, Jurlander, Birgit, additional, Kragelund, Charlotte, additional, Dominguez, Helena, additional, Schou, Morten, additional, and Therkelsen, Susette, additional

Published
2024
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21. Organized thrombus is a frequent underlying feature in culprit lesion morphology in non-ST-elevation myocardial infarction. A study using optical coherence tomography and magnetic resonance imaging

Author

Ekström, Kathrine, primary, Jensen, Maria Radu Juul, additional, Holmvang, Lene, additional, Joshi, Francis Richard, additional, Iversen, Allan Zeeberg, additional, Madsen, Per Lav, additional, Olsen, Niels Thue, additional, Pedersen, Frants, additional, Sørensen, Rikke, additional, Tilsted, Hans-Henrik, additional, Engstrøm, Thomas, additional, and Lønborg, Jacob, additional

Published
2023
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23. Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics

Author

Stampe, Niels Kjær, primary, Ottenheijm, Maud Eline, additional, Drici, Lylia, additional, Wewer Albrechtsen, Nicolai J, additional, Nielsen, Annelaura Bach, additional, Christoffersen, Christina, additional, Warming, Peder Emil, additional, Engstrøm, Thomas, additional, Winkel, Bo Gregers, additional, Jabbari, Reza, additional, Tfelt-Hansen, Jacob, additional, and Glinge, Charlotte, additional

Published
2023
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24. Coronary CT Angiography as a Guide to Timing of Invasive Treatment in Patients With NSTEACS

Author

Kühl, Jørgen T., primary, Kelbæk, Henning, additional, Linde, Jesper J., additional, Sigvardsen, Per E., additional, Hansen, Thomas F., additional, de Knegt, Martina C., additional, Heitmann, Merete, additional, Hansen, Peter R., additional, Høfsten, Dan, additional, Bang, Lia E., additional, Hove, Jens D., additional, Kragelund, Charlotte, additional, Abdulla, Jawdat, additional, Holmvang, Lene, additional, Torp-Pedersen, Christian, additional, Gislason, Gunnar, additional, Engstrøm, Thomas, additional, Køber, Lars V., additional, and Kofoed, Klaus F., additional

Published
2023
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27. Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy

Author

Francis, Rohin, Chong, Jun, Ramlall, Manish, Bucciarelli-Ducci, Chiara, Clayton, Tim, Dodd, Matthew, Engstrøm, Thomas, Evans, Richard, Ferreira, Vanessa M., Fontana, Marianna, Greenwood, John P., Kharbanda, Rajesh K., Kim, Won Yong, Kotecha, Tushar, Lønborg, Jacob T., Mathur, Anthony, Møller, Ulla Kristine, Moon, James, Perkins, Alexander, Rakhit, Roby D., Yellon, Derek M., Bøtker, Hans Erik, Bulluck, Heerajnarain, and Hausenloy, Derek J.

Published
2021
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30. Influenza Vaccination After Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

Author

Fröbert, Ole, Götberg, Matthias, Erlinge, David, Akhtar, Zubair, Christiansen, Evald H., MacIntyre, Chandini R., Oldroyd, Keith G., Motovska, Zuzana, Erglis, Andrejs, Moer, Rasmus, Hlinomaz, Ota, Jakobsen, Lars, Engstrøm, Thomas, Jensen, Lisette O., Fallesen, Christian O., Jensen, Svend E, Angerås, Oskar, Calais, Fredrik, Kåregren, Amra, Lauermann, Jörg, Mokhtari, Arash, Nilsson, Johan, Persson, Jonas, Stalby, Per, Islam, Abu K.M.M., Rahman, Afzalur, Malik, Fazila, Choudhury, Sohel, Collier, Timothy, Pocock, Stuart J., and Pernow, John

Published
2021
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32. Prevalence and Impact of Frailty in Patients ≥70 Years Old with Acute Coronary Syndrome Referred for Coronary Angiography.

Author

Ratcovich, Hanna, Joshi, Francis R., Palm, Pernille, Færch, Jane, Bang, Lia E., Tilsted, Hans-Henrik, Sadjadieh, Golnaz, Engstrøm, Thomas, and Holmvang, Lene

Subjects
ACUTE coronary syndrome, CORONARY angiography, DISEASE risk factors, FRAILTY, OLDER patients
Abstract

Introduction: Elderly patients with acute coronary syndrome (ACS) have a higher risk of adverse cardiovascular events and may be frail but are underrepresented in clinical trials. Previous studies have proposed that frailty assessment is a better tool than chronological age, in assessing older patients' biological age, and may exceed conventional risk scores in predicting the prognosis. Therefore, we wanted to investigate the prevalence and impact on 12-month outcomes of frailty in patients ≥70 years with ACS referred for coronary angiography (CAG). Methods: Patients ≥70 years with ACS referred for CAG underwent frailty scoring with the clinical frailty scale (CFS). Patients were divided into three groups depending on their CFS: robust (1–3), vulnerable (4), and frail (5–9) and followed for 12 months. Results: Of 455 patients, 69 (15%) patients were frail, 79 (17%) were vulnerable, and 307 (68%) were robust. Frail patients were older (frail: 80.9 ± 5.7 years, vulnerable: 78.5 ± 5.5 years, and robust: 76.6 ± 4.9 years, p < 0.001) and less often treated with percutaneous coronary intervention (frail: 56.5%, vulnerable: 53.2%, and robust: 68.6%, p = 0.014). 12-month mortality was higher among frail patients (frail: 24.6%, vulnerable: 21.8%, and robust: 6.2%, p < 0.001). Frailty was associated with a higher mortality after adjustment for age, sex, comorbidities, the Global Registry of Acute Coronary Events (GRACE) score, and revascularisation (HR 2.67, 95% CI 1.30–5.50, p = 0.008). There was no difference between GRACE and CFS in predicting 12-month mortality (p = 0.893). Conclusions: Fifteen percent of patients ≥70 years old with ACS referred for CAG are frail. Frail patients have significantly higher 12-month mortality. GRACE and CFS are similar in predicting 12-month mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Pre-Hospital Pulse Glucocorticoid Therapy in Patients with ST-Segment Elevation Myocardial Infarction Transferred for Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial (PULSE-MI)

Author

Madsen, Jasmine Melissa, primary, Obling, Laust Emil Roelsgaard, additional, Rytoft, Laura, additional, Folke, Fredrik, additional, Hassager, Christian, additional, Andersen, Lars Bredevang, additional, Vejlstrup, Niels, additional, Bang, Lia Evi, additional, Engstrøm, Thomas, additional, and Lønborg, Jacob Thomsen, additional

Published
2023
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36. Bleeding risk and P2Y12 inhibitors in all-comer patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: a single-centre cohort study

Author

Jacobsen, Mia Ravn, primary, Jabbari, Reza, additional, Engstrøm, Thomas, additional, Grove, Erik Lerkevang, additional, Glinge, Charlotte, additional, Pedersen, Frants, additional, Holmvang, Lene, additional, Køber, Lars, additional, Torp-Pedersen, Christian, additional, Maeng, Michael, additional, Veien, Karsten, additional, Freeman, Phillip, additional, Charlot, Mette Gitz, additional, Kelbæk, Henning, additional, and Sørensen, Rikke, additional

Published
2023
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37. Impact of alirocumab on plaque regression and haemodynamics of non-culprit arteries in patients with acute myocardial infarction: a prespecified substudy of the PACMAN-AMI trial

Author

Bär, Sarah, primary, Kavaliauskaite, Raminta, additional, Otsuka, Tatsuhiko, additional, Ueki, Yasushi, additional, Häner, Jonas D., additional, Siontis, George C.M., additional, Stortecky, Stefan, additional, Shibutani, Hiroki, additional, Temperli, Fabrice, additional, Kaiser, Christoph, additional, Iglesias, Juan F., additional, Jan van Geuns, Robert, additional, Daemen, Joost, additional, Spirk, David, additional, Engstrøm, Thomas, additional, Lang, Irene, additional, Windecker, Stephan, additional, Koskinas, Konstantinos C., additional, Losdat, Sylvain, additional, and Räber, Lorenz, additional

Published
2023
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39. Myocardial scarring and recurrence of ventricular arrhythmia in patients surviving an out‐of‐hospital cardiac arrest.

Author

Thomsen, Anna F., Winkel, Bo G., Golvano, Leticia Camino Castrillo, Porta‐Sánchez, Andreu, Jøns, Christian, Ferro, Elisenda, Bertelsen, Litten, Vazquez, Sara, Bhardwaj, Priya, Stampe, Niels Kjær, Ortiz‐Perez, José T., Andrea, Rut, Engstrøm, Thomas, Køber, Lars, Vejlstrup, Niels, Mont, Lluís, Roca‐Luque, Ivo, and Jacobsen, Peter K.

Subjects
DIGITAL image processing, MYOCARDIUM, HUMAN research subjects, ANALYSIS of variance, CONFIDENCE intervals, MAGNETIC resonance imaging, RETROSPECTIVE studies, MANN Whitney U Test, FISHER exact test, DISEASE relapse, RISK assessment, INFORMED consent (Medical law), DIAGNOSTIC imaging, T-test (Statistics), CARDIAC arrest, VENTRICULAR arrhythmia, DESCRIPTIVE statistics, SENSITIVITY & specificity (Statistics), RECEIVER operating characteristic curves, DATA analysis software, DISEASE risk factors
Abstract

Introduction: Prediction of recurrent ventricular arrhythmia (VA) in survivors of an out‐of‐hospital cardiac arrest (OHCA) is important, but currently difficult. Risk of recurrence may be related to presence of myocardial scarring assessed with late gadolinium enhancement cardiac magnetic resonance (LGE‐CMR). Our study aims to characterize myocardial scarring as defined by LGE‐CMR in survivors of a VA‐OHCA and investigate its potential role in the risk of new VA events. Methods: Between 2015 and 2022, a total of 230 VA‐OHCA patients without ST‐segment elevation myocardial infarction had CMR before implantable cardioverter‐defibrillator implantation for secondary prevention at Copenhagen University Hospital, Rigshospitalet, and Hospital Clínic, University of Barcelona, of which n = 170 patients had a conventional (no LGE protocol) CMR and n = 60 patients had LGE‐CMR (including LGE protocol). Scar tissue including core, border zone (BZ) and BZ channels were automatically detected by specialized investigational software in patients with LGE‐CMR. The primary endpoint was recurrent VA. Results: After exclusion, n = 52 VA‐OHCA patients with LGE‐CMR and a mean left ventricular ejection fraction of 49 ± 16% were included, of which 18 (32%) patients reached the primary endpoint of VA. Patients with recurrent VA in exhibited greater scar mass, core mass, BZ mass, and presence of BZ channels compared with patients without recurrent VA. The presence of BZ channels identified patients with recurrent VA with 67% sensitivity and 85% specificity (area under the ROC curve (AUC) 0.76; 95% CI: 0.63–0.89; p <.001) and was the strongest predictor of the primary endpoint. Conclusions: The presence of BZ channels was the strongest predictor of recurrent VA in patients with an out of‐hospital cardiac arrest and LGE‐CMR. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Coronary Artery Lesion Lipid Content and Plaque Burden in Diabetic and Nondiabetic Patients: PROSPECT II

Author

Gyldenkerne, Christine, primary, Maeng, Michael, additional, Kjøller-Hansen, Lars, additional, Maehara, Akiko, additional, Zhou, Zhipeng, additional, Ben-Yehuda, Ori, additional, Erik Bøtker, Hans, additional, Engstrøm, Thomas, additional, Matsumura, Mitsuaki, additional, Mintz, Gary S., additional, Fröbert, Ole, additional, Persson, Jonas, additional, Wiseth, Rune, additional, Larsen, Alf I., additional, Jensen, Lisette O., additional, Nordrehaug, Jan E., additional, Bleie, Øyvind, additional, Omerovic, Elmir, additional, Held, Claes, additional, James, Stefan K., additional, Ali, Ziad A., additional, Rosen, Hans C., additional, Stone, Gregg W., additional, and Erlinge, David, additional

Published
2023
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41. Long-term changes in coronary physiology after aortic valve replacement

Author

Sabbah, Muhammad, primary, Olsen, Niels T., additional, Holmvang, Lene, additional, Tilsted, Hans-Henrik, additional, Pedersen, Frants, additional, Joshi, Francis Richard, additional, Sørensen, Rikke, additional, Jabbari, Reza, additional, Arslani, Ketina, additional, Sondergaard, Lars, additional, Engstrøm, Thomas, additional, and Lønborg, Jacob Thomsen, additional

Published
2023
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42. Employment status at time of acute myocardial infarction and risk of death and recurrent acute myocardial infarction

Author

Petersen, Jeppe K, primary, Shams-Eldin, Abdulrahman N, additional, Fosbøl, Emil L, additional, Rørth, Rasmus, additional, Sørensen, Rikke, additional, Jabbari, Reza, additional, Engstrøm, Thomas, additional, Holmvang, Lene, additional, Pedersen, Frants, additional, Alhakak, Amna, additional, Krøll, Johanna, additional, Torp-Pedersen, Christian, additional, Køber, Lars, additional, and Butt, Jawad H, additional

Published
2023
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43. The Incidence and Impact of Permanent Right Ventricular Infarction on Left Ventricular Infarct Size in Patients With Inferior ST-Segment Elevation Myocardial Infarction

Author

Juul, Anne-Sophie, primary, Kyhl, Kasper, additional, Ekström, Kathrine, additional, Madsen, Jasmine Melissa, additional, Sabbah, Muhammad, additional, Ahtarovski, Kiril Aleksov, additional, Nepper-Christensen, Lars, additional, Vejlstrup, Niels, additional, Høfsten, Dan, additional, Kelbaek, Henning, additional, Køber, Lars, additional, Lønborg, Jacob, additional, and Engstrøm, Thomas, additional

Published
2023
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44. Impact of alirocumab on plaque regression and haemodynamics of non-culprit arteries in patients with acute myocardial infarction: a prespecified substudy of the PACMAN-AMI trial

Author

Bär, Sarah, Kavaliauskaite, Raminta, Otsuka, Tatsuhiko, Ueki, Yasushi, Häner, Jonas D, Siontis, George C M, Stortecky, Stefan, Shibutani, Hiroki, Temperli, Fabrice, Kaiser, Christoph, Iglesias, Juan, Jan van Geuns, Robert, Daemen, Joost, Spirk, David, Engstrøm, Thomas, Lang, Irene, Windecker, Stephan, Koskinas, Konstantinos C, Losdat, Sylvain, and Räber, Lorenz

Subjects
610 Medicine & health
Abstract

BACKGROUND Treatment with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on top of statins leads to plaque regression and stabilisation. The effects of PCSK9 inhibitors on coronary physiology and angiographic diameter stenosis (DS%) are unknown. AIMS This study aimed to investigate the effects of the PCSK9 inhibitor alirocumab on coronary haemodynamics as assessed by quantitative flow ratio (QFR) and DS% by three-dimensional quantitative coronary angiography (3D-QCA) in non-infarct-related arteries (non-IRA) among acute myocardial infarction (AMI) patients. METHODS This was a prespecified substudy of the randomised controlled PACMAN-AMI trial, comparing alirocumab versus placebo on top of rosuvastatin. QFR and 3D-QCA were assessed at baseline and 1 year in any non-IRA ≥2.0 mm and 3D-QCA DS% >25%. The prespecified primary endpoint was the number of patients with a mean QFR increase at 1 year, and the secondary endpoint was the change in 3D-QCA DS%. RESULTS Of 300 enrolled patients, 265 had serial follow-up, of which 193 underwent serial QFR/3D-QCA analysis in 282 non-IRA. At 1 year, QFR increased in 50/94 (53.2%) patients with alirocumab versus 40/99 (40.4%) with placebo (Δ12.8%; odds ratio 1.7, 95% confidence interval [CI]: 0.9 to 3.0; p=0.076). DS% decreased by 1.03±7.28% with alirocumab and increased by 1.70±8.27% with placebo (Δ-2.50%, 95% CI: -4.43 to -0.57; p=0.011). CONCLUSIONS Treatment of AMI patients with alirocumab versus placebo for 1 year resulted in a significant regression in angiographic DS%, whereas no overall improvement of coronary haemodynamics was observed. CLINICALTRIALS gov: NCT03067844.

Published
2023
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45. Scar border zone mass and presence of border zone channels assessed with cardiac magnetic resonance imaging are associated with ventricular arrhythmia in patients with ST-segment elevation myocardial infarction

Author

Thomsen, Anna F, primary, Bertelsen, Litten, additional, Jøns, Christian, additional, Jabbari, Reza, additional, Lønborg, Jacob, additional, Kyhl, Kasper, additional, Göransson, Christoffer, additional, Nepper-Christensen, Lars, additional, Atharovski, Kiril, additional, Ekström, Kathrine, additional, Tilsted, Hans-Henrik, additional, Pedersen, Frants, additional, Køber, Lars, additional, Engstrøm, Thomas, additional, Vejlstrup, Niels, additional, and Jacobsen, Peter Karl, additional

Published
2022
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46. Long-term risk of new-onset arrhythmia in ST-segment elevation myocardial infarction according to revascularization status

Author

Thomsen, Anna F, primary, Jøns, Christian, additional, Jabbari, Reza, additional, Jacobsen, Mia R, additional, Stampe, Niels Kjær, additional, Butt, Jawad H, additional, Olsen, Niels Thue, additional, Kelbæk, Henning, additional, Torp-Pedersen, Christian, additional, Fosbøl, Emil L, additional, Pedersen, Frants, additional, Køber, Lars, additional, Engstrøm, Thomas, additional, and Jacobsen, Peter Karl, additional

Published
2022
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47. Soluble ST2 in plasma is associated with post-procedural no-or-slow reflow after primary percutaneous coronary intervention in ST-elevation myocardial infarction

Author

Søndergaard, Frederik T, primary, Beske, Rasmus P, additional, Frydland, Martin, additional, Møller, Jacob Eifer, additional, Helgestad, Ole K L, additional, Jensen, Lisette Okkels, additional, Holmvang, Lene, additional, Goetze, Jens P, additional, Engstrøm, Thomas, additional, and Hassager, Christian, additional

Published
2022
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48. Coronary CT and timing of invasive coronary angiography in patients ≥75 years old with non-ST segment elevation acute coronary syndromes

Author

Ratcovich, Hanna, primary, Sadjadieh, Golnaz, additional, Linde, Jesper J, additional, Joshi, Francis R, additional, Kelbæk, Henning, additional, Kofoed, Klaus F, additional, Køber, Lars, additional, Hansen, Peter Riis, additional, Torp-Pedersen, Christian, additional, Elming, Hanne, additional, Gislason, Gunnar Hilmar, additional, Høfsten, Dan Eik, additional, Engstrøm, Thomas, additional, and Holmvang, Lene, additional

Published
2022
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49. On the Natural History of Coronary Artery Disease: A Longitudinal Nationwide Serial Angiography Study

Author

Mohammad, Moman A., primary, Stone, Gregg W., additional, Koul, Sasha, additional, Olivecrona, Göran K., additional, Bergman, Sofia, additional, Persson, Jonas, additional, Engstrøm, Thomas, additional, Fröbert, Ole, additional, Jernberg, Tomas, additional, Omerovic, Elmir, additional, James, Stefan, additional, Bergström, Göran, additional, and Erlinge, David, additional

Published
2022
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50. Myocardial infarction without obstructive coronary artery disease

Author

Mohamed, Abdullahi Ahmed, Bøttcher, Morten, Engstrøm, Thomas, Kim, Won Yong, Christiansen, Evald Høj, and Winther, Simon

Abstract

Myocardial infarction with non-obstructive coronary arteries (MINOCA) is characterized by clinical evidence of myocardial infarction with normal or near-normal coronary arteries on angiography (less-than 50% stenosis). MINOCA is a group of heterogeneous diseases with different pathophysiologic mechanism which all can cause ischaemia. MINOCA is considered a "working diagnosis" after angiography until further evaluation regarding its underlying cause is made. The aim of this review is to assess the literature on clinical features, aetiology, diagnosis, treatment and prognosis of patients with MINOCA.

Published
2022

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