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241 results on '"Emdad, Luni"'

5. Preface

Author

Emdad, Luni, primary, Atfi, Azeddine, additional, Gogna, Rajan, additional, Trevino, Jose G., additional, and Fisher, Paul B., additional

Published
2023
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6. Noninvasive therapy of brain cancer using a unique systemic delivery methodology with a cancer terminator virus.

Author

Bhoopathi, Praveen, Mannangatti, Padmanabhan, Pradhan, Anjan K., Kumar, Amit, Maji, Santanu, Lang, Frederick F., Klibanov, Alexander L., Madan, Esha, Cavenee, Webster K., Keoprasert, Timothy, Sun, Dong, Bjerkvig, Rolf, Thorsen, Frits, Gogna, Rajan, Das, Swadesh K., Emdad, Luni, and Fisher, Paul B.

Subjects
SECONDARY primary cancer, BRAIN tumors, BRAIN cancer, THERAPEUTICS, ONCOGENIC viruses, VIRAL tropism
Abstract

Primary, glioblastoma, and secondary brain tumors, from metastases outside the brain, are among the most aggressive and therapeutically resistant cancers. A physiological barrier protecting the brain, the blood–brain barrier (BBB), functions as a deterrent to effective therapies. To enhance cancer therapy, we developed a cancer terminator virus (CTV), a unique tropism‐modified adenovirus consisting of serotype 3 fiber knob on an otherwise Ad5 capsid that replicates in a cancer‐selective manner and simultaneously produces a potent therapeutic cytokine, melanoma differentiation‐associated gene‐7/interleukin‐24 (MDA‐7/IL‐24). A limitation of the CTV and most other viruses, including adenoviruses, is an inability to deliver systemically to treat brain tumors because of the BBB, nonspecific virus trapping, and immune clearance. These obstacles to effective viral therapy of brain cancer have now been overcome using focused ultrasound with a dual microbubble treatment, the focused ultrasound‐double microbubble (FUS‐DMB) approach. Proof‐of‐principle is now provided indicating that the BBB can be safely and transiently opened, and the CTV can then be administered in a second set of complement‐treated microbubbles and released in the brain using focused ultrasound. Moreover, the FUS‐DMB can be used to deliver the CTV multiple times in animals with glioblastoma growing in their brain thereby resulting in a further enhancement in survival. This strategy permits efficient therapy of primary and secondary brain tumors enhancing animal survival without promoting harmful toxic or behavioral side effects. Additionally, when combined with a standard of care therapy, Temozolomide, a further increase in survival is achieved. The FUS‐DMB approach with the CTV highlights a noninvasive strategy to treat brain cancers without surgery. This innovative delivery scheme combined with the therapeutic efficacy of the CTV provides a novel potential translational therapeutic approach for brain cancers. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Cytoplasmic-delivery of polyinosine-polycytidylic acid inhibits pancreatic cancer progression increasing survival by activating Stat1-CCL2-mediated immunity

Author

Bhoopathi, Praveen, primary, Kumar, Amit, additional, Pradhan, Anjan K, additional, Maji, Santanu, additional, Mannangatti, Padmanabhan, additional, Windle, Jolene J, additional, Subler, Mark A, additional, Zhang, Dongyu, additional, Vudatha, Vignesh, additional, Trevino, Jose G, additional, Madan, Esha, additional, Atfi, Azeddine, additional, Sarkar, Devanand, additional, Gogna, Rajan, additional, Das, Swadesh K, additional, Emdad, Luni, additional, and Fisher, Paul B, additional

Published
2023
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9. Supplementary Fig. S6 from Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis

Author

Pradhan, Anjan K., primary, Modi, Jinkal, primary, Maji, Santanu, primary, Kumar, Amit, primary, Bhoopathi, Praveen, primary, Mannangatti, Padmanabhan, primary, Guo, Chunqing, primary, Afosah, Daniel K., primary, Mochel, Mark C., primary, Mukhopadhyay, Nitai D., primary, Kirkwood, John M., primary, Wang, Xiang-Yang, primary, Desai, Umesh R., primary, Sarkar, Devanand, primary, Emdad, Luni, primary, Das, Swadesh K., primary, and Fisher, Paul B., primary

Published
2023
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10. Data from Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis

Author

Pradhan, Anjan K., primary, Modi, Jinkal, primary, Maji, Santanu, primary, Kumar, Amit, primary, Bhoopathi, Praveen, primary, Mannangatti, Padmanabhan, primary, Guo, Chunqing, primary, Afosah, Daniel K., primary, Mochel, Mark C., primary, Mukhopadhyay, Nitai D., primary, Kirkwood, John M., primary, Wang, Xiang-Yang, primary, Desai, Umesh R., primary, Sarkar, Devanand, primary, Emdad, Luni, primary, Das, Swadesh K., primary, and Fisher, Paul B., primary

Published
2023
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11. Supplementary Data from Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis

Author

Pradhan, Anjan K., primary, Modi, Jinkal, primary, Maji, Santanu, primary, Kumar, Amit, primary, Bhoopathi, Praveen, primary, Mannangatti, Padmanabhan, primary, Guo, Chunqing, primary, Afosah, Daniel K., primary, Mochel, Mark C., primary, Mukhopadhyay, Nitai D., primary, Kirkwood, John M., primary, Wang, Xiang-Yang, primary, Desai, Umesh R., primary, Sarkar, Devanand, primary, Emdad, Luni, primary, Das, Swadesh K., primary, and Fisher, Paul B., primary

Published
2023
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12. Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis

Author

Pradhan, Anjan K., primary, Modi, Jinkal, additional, Maji, Santanu, additional, Kumar, Amit, additional, Bhoopathi, Praveen, additional, Mannangatti, Padmanabhan, additional, Guo, Chunqing, additional, Afosah, Daniel K., additional, Mochel, Mark C., additional, Mukhopadhyay, Nitai D., additional, Kirkwood, John M., additional, Wang, Xiang-Yang, additional, Desai, Umesh R., additional, Sarkar, Devanand, additional, Emdad, Luni, additional, Das, Swadesh K., additional, and Fisher, Paul B., additional

Published
2023
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13. MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis.

Author

Maji, Santanu, Pradhan, Anjan K., Kumar, Amit, Bhoopathi, Praveen, Mannangatti, Padmanabhan, Chunqing Guo, Windle, Jolene J., Subler, Mark A., Xiang-Yang Wang, Semmes, Oliver J., Nyalwidhe, Julius O., Mukhopadhyay, Nitai, Paul, Asit Kr, Hatfield, Bryce, Levit, Michael M., Madan, Esha, Sarkar, Devanand, Emdad, Luni, Cohen, David J., and Gogna, Rajan

Subjects
BONE metastasis, METASTASIS, BONE cancer, TUMOR microenvironment, PROSTATE cancer, POLYMETHYLMETHACRYLATE
Abstract

Bone metastasis is a frequent and incurable consequence of advanced prostate cancer (PC). An interplay between disseminated tumor cells and heterogeneous bone resident cells in the metastatic niche initiates this process. Melanoma differentiation associated gene-9 (mda-9/Syntenin/syndecan binding protein) is a prometastatic gene expressed in multiple organs, including bone marrow-derived mesenchymal stromal cells (BM-MSCs), under both physiological and pathological conditions. We demonstrate that PDGF-AA secreted by tumor cells induces CXCL5 expression in BM-MSCs by suppressing MDA-9-dependent YAP/MST signaling. CXCL5-derived tumor cell proliferation and immune suppression are consequences of the MDA-9/CXCL5 signaling axis, promoting PC disease progression. mda-9 knockout tumor cells express less PDGF-AA and do not develop bone metastases. Our data document a previously undefined role of MDA-9/Syntenin in the tumor and microenvironment in regulating PC bone metastasis. This study provides a framework for translational strategies to ameliorate health complications and morbidity associated with advanced PC. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Abstract 3394: Simultaneous targeting of the PDZ1 and PDZ2 domains of MDA-9 inhibits melanoma metastasis

Author

Pradhan, Anjan K., primary, Modi, Jinkal, additional, Maji, Santanu, additional, Kumar, Amit, additional, Bhoopathi, Praveen, additional, Mannangatti, Padmanabhan, additional, Guo, Chunqing, additional, Afosah, Daniel K., additional, Mochel, Mark, additional, Mukhopadhyay, Nitai D., additional, Kirkwood, John M., additional, Wang, Xiang-Yang, additional, Desai, Umesh R., additional, Sarkar, Devanand, additional, Emdad, Luni, additional, Das, Swadesh K., additional, and Fisher, Paul B., additional

Published
2023
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29. Data from MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

Author

Park, Margaret A., primary, Walker, Teneille, primary, Martin, Aditi Pandya, primary, Allegood, Jeremy, primary, Vozhilla, Nicollaq, primary, Emdad, Luni, primary, Sarkar, Devanand, primary, Rahmani, Mohammed, primary, Graf, Martin, primary, Yacoub, Adly, primary, Koumenis, Costas, primary, Spiegel, Sarah, primary, Curiel, David T., primary, Voelkel-Johnson, Christina, primary, Grant, Steven, primary, Fisher, Paul B., primary, and Dent, Paul, primary

Published
2023
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32. Supplementary Fig. from MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

Author

Park, Margaret A., primary, Walker, Teneille, primary, Martin, Aditi Pandya, primary, Allegood, Jeremy, primary, Vozhilla, Nicollaq, primary, Emdad, Luni, primary, Sarkar, Devanand, primary, Rahmani, Mohammed, primary, Graf, Martin, primary, Yacoub, Adly, primary, Koumenis, Costas, primary, Spiegel, Sarah, primary, Curiel, David T., primary, Voelkel-Johnson, Christina, primary, Grant, Steven, primary, Fisher, Paul B., primary, and Dent, Paul, primary

Published
2023
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48. Supplementary Table S6 from Genetic Deletion of AEG-1 Prevents Hepatocarcinogenesis

Author

Robertson, Chadia L., primary, Srivastava, Jyoti, primary, Siddiq, Ayesha, primary, Gredler, Rachel, primary, Emdad, Luni, primary, Rajasekaran, Devaraja, primary, Akiel, Maaged, primary, Shen, Xue-Ning, primary, Guo, Chunqing, primary, Giashuddin, Shah, primary, Wang, Xiang-Yang, primary, Ghosh, Shobha, primary, Subler, Mark A., primary, Windle, Jolene J., primary, Fisher, Paul B., primary, and Sarkar, Devanand, primary

Published
2023
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49. Data from MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma

Author

Das, Swadesh K., primary, Bhutia, Sujit K., primary, Azab, Belal, primary, Kegelman, Timothy P., primary, Peachy, Leyla, primary, Santhekadur, Prasanna K., primary, Dasgupta, Santanu, primary, Dash, Rupesh, primary, Dent, Paul, primary, Grant, Steven, primary, Emdad, Luni, primary, Pellecchia, Maurizio, primary, Sarkar, Devanand, primary, and Fisher, Paul B., primary

Published
2023
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50. Supplementary Figure 1 from Oncogene AEG-1 Promotes Glioma-Induced Neurodegeneration by Increasing Glutamate Excitotoxicity

Author

Lee, Seok-Geun, primary, Kim, Keetae, primary, Kegelman, Timothy P., primary, Dash, Rupesh, primary, Das, Swadesh K., primary, Choi, Jung Kyoung, primary, Emdad, Luni, primary, Howlett, Eric L., primary, Jeon, Hyun Yong, primary, Su, Zhao Zhong, primary, Yoo, Byoung Kwon, primary, Sarkar, Devanand, primary, Kim, Sung-Hoon, primary, Kang, Dong-Chul, primary, and Fisher, Paul B., primary

Published
2023
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