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3. Brodalumab: 5-Year US Pharmacovigilance Report

Author

Mark G. Lebwohl, John Y. Koo, April W. Armstrong, Bruce E. Strober, George M. Martin, Nicole N. Rawnsley, Earl L. Goehring, and Abby A. Jacobson

Subjects
Adverse events, Drug reaction, Psoriasis, Real-world, Safety, Dermatology, RL1-803
Abstract

Abstract Introduction Brodalumab is a human interleukin-17 receptor A antagonist indicated for the treatment of moderate-to-severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy and have failed to respond or have lost response to other systemic therapies. Although the US prescribing information for brodalumab includes a boxed warning regarding suicidal ideation and behavior, no causal association has been demonstrated. Here, we summarize 5 years of pharmacovigilance data, from August 15, 2017, through August 14, 2022, reported to Ortho Dermatologics by US patients and healthcare providers. Methods Prevalence of the most common adverse events (AEs) listed in the brodalumab package insert (incidence ≥ 1%) and AEs of special interest are described. Brodalumab exposure was estimated as the time from the first to last prescription-dispensing authorization dates. Data were collected from 4744 patients in the USA, with an estimated exposure of 5815 patient-years. Results Over 5 years, 11 cases of adjudicated major adverse cardiovascular events were reported (0.23 events/100 patients), a rate lower than that experienced by patients in the international Psoriasis Longitudinal Assessment and Registry. There were 106 serious infections. No serious fungal infections were reported. There were 40 confirmed and 2 suspected COVID-19 cases, with no new COVID-19-related deaths. Of 49 reported malignancies among 42 patients, 3 were deemed possibly related to brodalumab. No completed suicides and no new suicidal attempts were reported. Conclusion Five-year pharmacovigilance data are consistent with the established safety profile reported in long-term clinical trials and previous pharmacovigilance reports, with no new safety signals.

Published
2024
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4. Assessment of Grapefruit Expressing Anti-NodT Antibody for Huanglongbing Resistance

Author

Chad Vosburg, Judith P. Sinn, Vladimir Orbovic, Rhuanito Soranz Ferrarezi, J. Martin Zapien Macias, Earl L. Taylor, Mark Hilf, Greg McCollum, Tim R. Gottwald, Ed Stover, and Timothy W. McNellis

Subjects
citrus greening, HLB, single-chain antibody, transformation, Plant culture, SB1-1110, Botany, QK1-989
Abstract

Growers rely on broad-spectrum agrochemicals to manage one of the most economically important fruit tree diseases, huanglongbing (HLB, citrus greening disease), presumptively caused by the gram-negative bacterium ‘Candidatus Liberibacter asiaticus’ (CLas). Although genetic resistance would be an attractive alternative to chemical management, this option is not yet available for HLB. Here, we tested whether a single chain variable fragment (scFv) antibody targeting the predicted CLas outer membrane transporter NodT can inhibit CLas growth or HLB disease development when expressed in ‘Duncan’ grapefruit (Citrus × paradisi). CLas NodT is similar to TolC and could be involved in Type I secretion and virulence. The scFv antibody was expressed in grapefruit trees as a C-terminal translational fusion to the Flowering Locus T protein of Poncirus trifoliata (FT-scFv) to promote expression in the phloem. Wild-type and FT-scFv-expressing transgenic lines were challenged with CLas using three inoculation approaches: psyllid-mediated inoculation, vegetative graft inoculation, and natural exposure in grove-like conditions. With the first two approaches, HLB symptom expression and CLas bacterial titers in FT-scFv grapefruit lines were not significantly different from wild-type controls. In the grove trial, one FT-scFv line exhibited a slight, but significant, reduction in canopy chlorosis compared to wild-type controls. Wild-type and FT-scFv lines were similar in all other metrics. We conclude that the expression of anti-NodT FT-scFv antibody in grapefruit did not decrease HLB susceptibility. Although our approach was unsuccessful, we hope that documenting our results will be useful for those seeking to develop HLB-resistant citrus germplasm in the future. [Figure: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.

Published
2024
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5. Structural changes in Florida citrus production, 1980-2021 and associated consequences of weather events and disease.

Author

Taylor, Earl L, Gottwald, Tim R, and Adkins, Scott

Subjects
Florida citrus production, freeze events, hurricane, Asiatic citrus canker (ACC), Huanglongbing (HLB), structural change
Abstract

Florida citrus production from 1980-2021 was examined and modeled to determine the impacts associated with weather events and disease introductions.  Specifically, the study examined the effects of North Atlantic hurricanes, freezes events and two disease introductions -- Asiatic citrus canker (ACC), and Huanglongbing (HLB) -- on productions levels and on the structure of the Florida citrus industry.  The models estimated quantified the effects on production associated with the weather events and disease introductions.  Using the deterministic model generated, forecasts were generated to identify future implications of HLB on Florida citrus production.  Theses generated forecasts were compared to actual production levels and the USDA Crop forecast to test and validate the model.  Whereas testing indicated a significant structural change in the Florida citrus industry resulting from adverse weather events and disease introductions, published economic impact studies were examined and reviewed to gage the resulting reduction in total economic impact.

Published
2023

11. Vitamin C levels of selected Philippine indigenous berries as affected by fruit maturity and processing treatment

Author

Katherine Ann T. Castillo-Israel, Lloyd Earl L. Flandez, Arvin Paul P. Tuaño, Kristel June D. Sartagoda, and Ma. Carisse M. Compendio

Subjects
Berries, Bignay, Lipote, Flesh, HPLC, Maturity, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract

Abstract The Philippines as a tropical country is home to several indigenous berries that offer enough supply of health-promoting bioactive compounds like vitamin C. Vitamin C is an important micronutrient in the human diet that is usually supplied by fruits and vegetables. The amount of this vitamin in different products varies depending on the species, variety, maturity, processing, and other conditions. In this study, the vitamin C contents of selected Philippine indigenous berries such as bignay and lipote were evaluated as affected by fruit maturity and processing treatment. Fruits of two bignay (Antidesma bunius (Linn.) Spreng), varieties, ‘Common’ and ‘Kalabaw’, as well as of lipote (Syzygium polycephaloides (C. B. Rob.) Merr.), at three maturity stages (unripe, half-ripe, and fully ripe) were acquired in Laguna, Philippines. Samples were subjected to two processing treatments: blanched (90 ± 5 °C, 2 minutes) and steamed (105 ± 5 °C, 5 minutes), while control samples did not undergo processing treatment. The flesh and seeds were separated, lyophilized, extracted, and subjected to quantification of vitamin C using reversed-phase high performance liquid chromatography. Results showed that the vitamin C levels of both fruits were significantly affected by maturity, processing, and their interaction (P

Published
2023
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12. Effects of various processing methods on the dietary fiber and antioxidant properties of Bignay (Antidesma bunius L. Spreng) fruit

Author

Ara Fatima A. Carbonera, Liezl M. Atienza, Maria Amelita C. Estacio, Sheba Mae M. Duque, Rona Camille M. Lizardo-Agustin, Lloyd Earl L. Flandez, and Katherine Ann T. Castillo-Israel

Subjects
Bignay, Fiber content, Fruit processing, Phenolic compounds, Antioxidant activity, Food processing and manufacture, TP368-456
Abstract

Bignay (Antidesma bunius L. Spreng) is an indigenous fruit in the Philippines known for its bioactive compounds and is commonly preserved by conventional freezing. Processing can be done to improve its storage condition and convert it into functional ingredients. This study aimed to determine the effect of freeze-drying, oven drying (50°C), spray drying, and juice concentrating on the dietary fiber composition, phenolic compounds, and antioxidant activity of Bignay. Results showed that oven drying increased the total dietary fiber of Bignay by 29% while freeze drying resulted to an increase in total phenolics, total flavonoids, and total anthocyanin by 69%, 55%, and 66%, respectively, with an increase in antioxidant activity in terms of DPPH, FRAP, and ABTS by 57%, 15% and 31%, respectively. Spray drying was found to be the most detrimental method while juice concentration gave little to no significant effects. Epicatechin, catechin, and gallic acid were the main phenolic compounds quantified in the processed Bignay. The study recommends that freeze-drying is the best method followed by oven drying, concentration, and spray drying.

Published
2023
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14. Impact of drying on the bioactive compounds and antioxidant properties of bignay [Antidesma bunius (L.) Spreng.] pomace

Author

Claire S. Zubia, Gilda Melanie O. Babaran, Sheba Mae M. Duque, Lotis E. Mopera, Lloyd Earl L. Flandez, Katherine Ann T. Castillo-Israel, and Florencio C. Reginio

Subjects
Freeze-drying, Convection oven-drying, Antioxidants, Phenolics, Bignay, Pomace, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract

Abstract Bignay pomace is a processing byproduct that can be a source of bioactive compounds. However, a suitable dehydration method should be considered to efficiently valorize this waste material into high-value food ingredient and maximize its health-promoting properties. Bignay pomace was subjected to convection oven-drying and freeze-drying to investigate the effect of these pre-processing techniques on the physicochemical, bioactives, and antioxidant properties of the samples. Both drying methods significantly (p

Published
2023
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20. FEDERALISM AND THE DIGITAL DIVIDE: HOW SMART PERMITTING REFORMS CAN UNLEASH RURAL BROADBAND ACCESS.

Author

"BUDDY" CARTER, EARL L.

Subjects
*FEDERAL government, *DIGITAL divide, *BROADBAND communication systems, *INTERNET access, *INVESTMENTS, *TECHNOLOGICAL innovations
Abstract

Millions of Americans lack access to high-speed broadband, which is important for connectivity in the modern world. For me, as a Member of the House Committee on Energy and Commerce, closing this digital divide is a top priority. In this Essay, I discuss how a streamlined permitting process, as outlined by my American Broadband Deployment Act, can promote investment and innovation while also connecting more Americans with this vital service. [ABSTRACT FROM AUTHOR]

Published
2024

21. EE48 Healthcare Resource Utilization (HCRU), Quality of Life (QoL), and Employment Changes for Early, Middle and Late-Stage People with Amyotrophic Lateral Sclerosis (pALS) in Italy: Results from a Real-World Survey

Author

Stenson, K., primary, Guerrieri, E., additional, Santoni, L., additional, Mellor, J., additional, Wright, J., additional, Earl, L., additional, Ball, N., additional, Iqbal, H., additional, Thomas, O., additional, Barlow, S., additional, and Ticozzi, N., additional

Published
2023
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27. Retrospective Analysis of a Clinical Algorithm for Managing Childhood Myopia Progression

Author

Jeffrey, Cooper, Thomas, Aller, Earl L, Smith, Kevin, Chan, Sally M, Dillehay, and Brett, O'Connor

Subjects
Ophthalmology, Optometry
Abstract

As the myopia epidemic unfolds, there is growing urgency to identify and implement effective interventions to slow myopia progression. This investigation evaluated the effectiveness of an evidence-based myopia treatment algorithm in a clinical setting among 342 consecutive children.To evaluate effectiveness of a clinical treatment algorithm for myopia progression in children.A retrospective cohort analysis was performed using data from myopic children treated for at least 1 year with a defined treatment algorithm incorporating orthokeratology, multifocal lenses, and atropine. The main outcome measures were the percentage of children experiencing ≤0.25D of myopic cycloplegic spherical equivalent autorefraction (CSER) progression and ≤ 0.10 mm of axial elongation at 1, 2, and 3 years. The secondary outcome measures were the Cumulative Absolute Reduction of axial Elongation (CARE) values derived from age- and ethnicity-matched matched virtual control data at 1, 2, and 3 years.Mean annual CSER change (excluding orthokeratology) was -0.30 D, -0.20 D, and -0.13 D at 1, 2, and 3 years, respectively, with 59%, 56%, and 60% of patients demonstrating ≤0.25 D of change over the prior year. Mean annual axial elongation was 0.13 mm, 0.12 mm, and 0.09 mm at 1, 2, and 3 years, respectively, with 52%, 46%, and 65% of patients demonstrating ≤0.10 mm of change over the prior year. The CARE values were 0.11 mm, 0.20 mm, and 0.29 mm over 1, 2, and 3 years, respectively.The treatment algorithm demonstrated effective control of CSER and AL in a diverse group of progressive myopic children, supporting its use for the clinical management of childhood myopia.

Published
2022

28. On the Potential of Gallium- and Indium-Based Liquid Metal Membranes for Hydrogen Separation

Author

Leon R. S. Rosseau, José A. Medrano, Rajat Bhardwaj, Earl L. V. Goetheer, Ivo A. W. Filot, Fausto Gallucci, and Martin van Sint Annaland

Subjects
dense metal membrane, microkinetics, Sieverts’ law, hydrogen, liquid metals, Chemical technology, TP1-1185, Chemical engineering, TP155-156
Abstract

The concept of liquid metal membranes for hydrogen separation, based on gallium or indium, was recently introduced as an alternative to conventional palladium-based membranes. The potential of this class of gas separation materials was mainly attributed to the promise of higher hydrogen diffusivity. The postulated improvements are only beneficial to the flux if diffusion through the membrane is the rate-determining step in the permeation sequence. Whilst this is a valid assumption for hydrogen transport through palladium-based membranes, the relatively low adsorption energy of hydrogen on both liquid metals suggests that other phenomena may be relevant. In the current study, a microkinetic modeling approach is used to enable simulations based on a five-step permeation mechanism. The calculation results show that for the liquid metal membranes, the flux is limited by the dissociative adsorption over a large temperature range, and that the membrane flux is expected to be orders of magnitude lower compared to the membrane flux through pure palladium membranes. Even when accounting for the lower cost of the liquid metals compared to palladium, the latter still outperforms both gallium and indium in all realistic scenarios, in part due to the practical difficulties associated with making liquid metal thin films.

Published
2022
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30. The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

Author

Reiner, R.C., Welgan, C.A., Troeger, C.E., Baumann, M.M., Weiss, D.J., Deshpande, A., Blacker, B.F., Miller-Petrie, M.K., Earl, L., Bhatt, S., Abolhassani, H., Abosetugn, A.E., Abu-Gharbieh, E., Adekanmbi, V., Adetokunboh, O.O., Aghaali, M., Aji, B., Alahdab, F., Al-Aly, Z., Alhassan, R.K., Ali, S., Alizade, H., Aljunid, S.M., Almasi-Hashiani, A., Al-Mekhlafi, H.M., Altirkawi, K.A., Alvis-Guzman, N., Amare, A.T., Amini, S., Amugsi, D.A., Ancuceanu, R., Andrei, C.L., Ansari, F., Anvari, D., Appiah, S.C.Y., Arabloo, J., Aremu, O., Atout, M.M.W., Ausloos, M., Ausloos, F., Ayanore, M.A., Aynalem, Y.A., Azene, Z.N., Badawi, A., Baig, A.A., Banach, M., Bedi, N., Bhagavathula, A.S., Bhandari, D., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bhutta, Z.A., Bijani, A., Birhanu, T.T.M., Bitew, Z.W., Boloor, A., Brady, O.J., Butt, Z.A., Car, J., Carvalho, F., Casey, D.C., Chattu, V.K., Chowdhury, M.A.K., Chu, D.-., Coelho, C.H., Cook, A.J., Damiani, G., Daoud, F., Gela, J.D., Darwish, A.H., Daryani, A., Das, J.K., Davis Weaver, N., Deribe, K., Desalew, A., Dharmaratne, S.D., Dianatinasab, M., Diaz, D., Djalalinia, S., Dorostkar, F., Dubljanin, E., Duko, B., Dwyer-Lindgren, L., Effiong, A., El Sayed Zaki, M., El Tantawi, M., Enany, S., Fattahi, N., Feigin, V.L., Fernandes, E., Ferrara, P., Fischer, F., Foigt, N.A., Folayan, M.O., Foroutan, M., Frostad, J.J., Fukumoto, T., Gaidhane, A.M., Gebrekrstos, H.G.G.K., Gebremeskel, L., Gebreslassie, A.A., Gething, P.W., Gezae, K.E., Ghadiri, K., Ghashghaee, A., Golechha, M., Gubari, M.I.M., Hadgu, F.B., Hamidi, S., Handiso, D.W., Hashi, A., Hassan, S., Hayat, K., Herteliu, C., H. C., H., Holla, R., Hosseinzadeh, M., Househ, M., Hussain, R., Hwang, B.-., Ibitoye, S.E., Ilesanmi, O.S., Ilic, I.M., Ilic, M.D., Irvani, S.S.N., Jaafari, J., Javaheri, T., Jha, R.P., Johnson, K.B., Jonas, J.B., Jozwiak, J.J., Kabir, A., Kalhor, R., Kanchan, T., Karch, A., Kayode, G.A., Keiyoro, P.N., Khader, Y.S., Khalil, I.A., Khan, M.N., Khan, M., Khan, G., Khatab, K., Khater, M.M., Khatib, M.N., Kianipour, N., Kim, Y.J., Kimokoti, R.W., Kisa, S., Kisa, A., Kissoon, N., Kochhar, S., Koolivand, A., Kopec, J.A., Koyanagi, A., Krishan, K., Kumar, P., Kurmi, O.P., Kusuma, D., Lal, D.K., Lami, F.H., Landires, I., Lansingh, V.C., Lasrado, S., La Vecchia, C., Lazzar-Atwood, A., Lee, P.H., Legrand, K.E., Lewycka, S., Li, B., Lim, S.S., Lindstedt, P.A., Liu, X., Longbottom, J., Lopez, A.D., Magdy Abd El Razek, H., Mahasha, P.W., Maleki, A., Mamun, A.A., Mansournia, M.A., Marczak, L.B., Martins-Melo, F.R., Mayala, B.K., Meharie, B.G., Melese, A., Mendoza, W., Menezes, R.G., Mengesha, E.W., Mensah, G.A., Meretoja, T.J., Mestrovic, T., Miller, T.R., Mirrakhimov, E.M., Moazen, B., Mohammad Gholi Mezerji, N., Mohammadi, S., Mohammed, S., Mokdad, A.H., Moradi, M., Moradzadeh, R., Moraga, P., Mosser, J.F., Murray, C.J.L., Naderi, M., Nagarajan, A.J., Nazari, J., Ndejjo, R., Negoi, I., Ngunjiri, J.W., Nguyen, Q.A.P., Nguyen, H.L.T., Nnaji, C.A., Noubiap, J.J., Nunez-Samudio, V., Olagunju, A.T., Olusanya, J.O., Olusanya, B.O., Omer, M.O., Onwujekwe, O.E., Otstavnov, N., Otstavnov, S.S., Owolabi, M.O., P A, M., Padubidri, J.R., Pana, A., Peprah, E.K., Pham, H.Q., Pigott, D.M., Pirestani, M., Postma, M.J., Pottoo, F.H., Pourjafar, H., Quazi Syed, Z., Rahim, F., Rahimi-Movaghar, V., Rahman, M.H.U., Rao, S.J., Rao, P.C., Rathi, P., Rawaf, S., Rawaf, D.L., Rawal, L., Rawassizadeh, R., Regassa, L.D., Renzaho, A.M.N., Rezaei, N., Rezai, M.S., Ribeiro, A.I., Rickard, J., Rios-Gonzalez, C.M., Rumisha, S.F., Sabour, S., Sajadi, S.M., Salomon, J.A., Samadi Kafil, H., Samy, A.M., Sanabria, J., Sartorius, B., Saxena, D., Schaeffer, L.E., Senthilkumaran, S., Sha, F., Shaheen, A.A., Shaikh, M.A., Sharma, R., Sheikh, A., Shibuya, K., Shigematsu, M., Il Shin, J., Simonetti, B., Singh, J.A., Smith, D.L., Soheili, A., Sokhan, A., Spurlock, E.E., Sreeramareddy, C.T., Sufiyan, M.B., Swartz, S.J., Tadesse, D.B., Tamiru, A.T., Tefera, Y.G., Temsah, M.-., Tessema, Z.T., Titova, M.V., Tran, B.X., Truong, P.N., Unnikrishnan, B., Upadhyay, E., Vasankari, T.J., Vasseghian, Y., Violante, F.S., G. T., V., Waheed, Y., Wamai, R.G., Wassie, E.G., Welay, F.T., Wickramasinghe, N.D., Wiens, K.E., Wijeratne, T., Wiysonge, C.S., Wondmeneh, T.G., Yamada, T., Yaya, S., Yeshitila, Y.G., Yip, P., Yonemoto, N., Yu, C., Yuce, D., Yusefzadeh, H., Zaidi, Z., Zamanian, M., Zangeneh, A., Zhang, Z.-., Zhang, Y., Ziapour, A., Hay, S.I., Reiner, RC Jr, Welgan, CA, Troeger, CE, Baumann, MM, Duko, Bereket, Hay, Simon I, LBD Triple Collaborators, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Reiner, R, Welgan, C, Troeger, C, Baumann, M, Weiss, D, Deshpande, A, Blacker, B, Miller-Petrie, M, Earl, L, Bhatt, S, Abolhassani, H, Abosetugn, A, Abu-Gharbieh, E, Adekanmbi, V, Adetokunboh, O, Aghaali, M, Aji, B, Alahdab, F, Al-Aly, Z, Alhassan, R, Ali, S, Alizade, H, Aljunid, S, Almasi-Hashiani, A, Al-Mekhlafi, H, Altirkawi, K, Alvis-Guzman, N, Amare, A, Amini, S, Amugsi, D, Ancuceanu, R, Andrei, C, Ansari, F, Anvari, D, Appiah, S, Arabloo, J, Aremu, O, Atout, M, Ausloos, M, Ausloos, F, Ayanore, M, Aynalem, Y, Azene, Z, Badawi, A, Baig, A, Banach, M, Bedi, N, Bhagavathula, A, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhutta, Z, Bijani, A, Birhanu, T, Bitew, Z, Boloor, A, Brady, O, Butt, Z, Car, J, Carvalho, F, Casey, D, Chattu, V, Chowdhury, M, Chu, D, Coelho, C, Cook, A, Damiani, G, Daoud, F, Gela, J, Darwish, A, Daryani, A, Das, J, Davis Weaver, N, Deribe, K, Desalew, A, Dharmaratne, S, Dianatinasab, M, Diaz, D, Djalalinia, S, Dorostkar, F, Dubljanin, E, Duko, B, Dwyer-Lindgren, L, Effiong, A, El Sayed Zaki, M, El Tantawi, M, Enany, S, Fattahi, N, Feigin, V, Fernandes, E, Ferrara, P, Fischer, F, Foigt, N, Folayan, M, Foroutan, M, Frostad, J, Fukumoto, T, Gaidhane, A, Gebrekrstos, H, Gebremeskel, L, Gebreslassie, A, Gething, P, Gezae, K, Ghadiri, K, Ghashghaee, A, Golechha, M, Gubari, M, Hadgu, F, Hamidi, S, Handiso, D, Hashi, A, Hassan, S, Hayat, K, Herteliu, C, Ho, H, Holla, R, Hosseinzadeh, M, Househ, M, Hussain, R, Hwang, B, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Irvani, S, Jaafari, J, Javaheri, T, Jha, R, Johnson, K, Jonas, J, Jozwiak, J, Kabir, A, Kalhor, R, Kanchan, T, Karch, A, Kayode, G, Keiyoro, P, Khader, Y, Khalil, I, Khan, M, Khan, G, Khatab, K, Khater, M, Khatib, M, Kianipour, N, Kim, Y, Kimokoti, R, Kisa, S, Kisa, A, Kissoon, N, Kochhar, S, Koolivand, A, Kopec, J, Koyanagi, A, Krishan, K, Kumar, P, Kurmi, O, Kusuma, D, Lal, D, Lami, F, Landires, I, Lansingh, V, Lasrado, S, La Vecchia, C, Lazzar-Atwood, A, Lee, P, Legrand, K, Lewycka, S, Li, B, Lim, S, Lindstedt, P, Liu, X, Longbottom, J, Lopez, A, Magdy Abd El Razek, H, Mahasha, P, Maleki, A, Mamun, A, Mansournia, M, Marczak, L, Martins-Melo, F, Mayala, B, Meharie, B, Melese, A, Mendoza, W, Menezes, R, Mengesha, E, Mensah, G, Meretoja, T, Mestrovic, T, Miller, T, Mirrakhimov, E, Moazen, B, Mohammad Gholi Mezerji, N, Mohammadi, S, Mohammed, S, Mokdad, A, Moradi, M, Moradzadeh, R, Moraga, P, Mosser, J, Murray, C, Naderi, M, Nagarajan, A, Nazari, J, Ndejjo, R, Negoi, I, Ngunjiri, J, Nguyen, Q, Nguyen, H, Nnaji, C, Noubiap, J, Nunez-Samudio, V, Olagunju, A, Olusanya, J, Olusanya, B, Omer, M, Onwujekwe, O, Otstavnov, N, Otstavnov, S, Owolabi, M, P A, M, Padubidri, J, Pana, A, Peprah, E, Pham, H, Pigott, D, Pirestani, M, Postma, M, Pottoo, F, Pourjafar, H, Quazi Syed, Z, Rahim, F, Rahimi-Movaghar, V, Rahman, M, Rao, S, Rao, P, Rathi, P, Rawaf, S, Rawaf, D, Rawal, L, Rawassizadeh, R, Regassa, L, Renzaho, A, Rezaei, N, Rezai, M, Ribeiro, A, Rickard, J, Rios-Gonzalez, C, Rumisha, S, Sabour, S, Sajadi, S, Salomon, J, Samadi Kafil, H, Samy, A, Sanabria, J, Sartorius, B, Saxena, D, Schaeffer, L, Senthilkumaran, S, Sha, F, Shaheen, A, Shaikh, M, Sharma, R, Sheikh, A, Shibuya, K, Shigematsu, M, Il Shin, J, Simonetti, B, Singh, J, Smith, D, Soheili, A, Sokhan, A, Spurlock, E, Sreeramareddy, C, Sufiyan, M, Swartz, S, Tadesse, D, Tamiru, A, Tefera, Y, Temsah, M, Tessema, Z, Titova, M, Tran, B, Truong, P, Unnikrishnan, B, Upadhyay, E, Vasankari, T, Vasseghian, Y, Violante, F, Vu, G, Waheed, Y, Wamai, R, Wassie, E, Welay, F, Wickramasinghe, N, Wiens, K, Wijeratne, T, Wiysonge, C, Wondmeneh, T, Yamada, T, Yaya, S, Yeshitila, Y, Yip, P, Yonemoto, N, Yu, C, Yuce, D, Yusefzadeh, H, Zaidi, Z, Zamanian, M, Zangeneh, A, Zhang, Z, Zhang, Y, Ziapour, A, Hay, S, HUS Comprehensive Cancer Center, Institute for Molecular Medicine Finland, Clinicum, Helsinki University Hospital Area, and Department of Oncology

Subjects
Multidisciplinary, Settore MED/42 - Igiene Generale e Applicata, 3122 Cancers, malaria, General Physics and Astronomy, COVID-19, General Chemistry, 3126 Surgery, anesthesiology, intensive care, radiology, infectious diseases, Sub-Saharian Africa, General Biochemistry, Genetics and Molecular Biology, Settore MED/01 - Statistica Medica, Children mortality, epidemiology, biogeography
Abstract

Publisher Copyright: © 2022, The Author(s). Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.

Published
2022

31. The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

Author

Reiner, R, Welgan, C, Troeger, C, Baumann, M, Weiss, D, Deshpande, A, Blacker, B, Miller-Petrie, M, Earl, L, Bhatt, S, Abolhassani, H, Abosetugn, A, Abu-Gharbieh, E, Adekanmbi, V, Adetokunboh, O, Aghaali, M, Aji, B, Alahdab, F, Al-Aly, Z, Alhassan, R, Ali, S, Alizade, H, Aljunid, S, Almasi-Hashiani, A, Al-Mekhlafi, H, Altirkawi, K, Alvis-Guzman, N, Amare, A, Amini, S, Amugsi, D, Ancuceanu, R, Andrei, C, Ansari, F, Anvari, D, Appiah, S, Arabloo, J, Aremu, O, Atout, M, Ausloos, M, Ausloos, F, Ayanore, M, Aynalem, Y, Azene, Z, Badawi, A, Baig, A, Banach, M, Bedi, N, Bhagavathula, A, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhutta, Z, Bijani, A, Birhanu, T, Bitew, Z, Boloor, A, Brady, O, Butt, Z, Car, J, Carvalho, F, Casey, D, Chattu, V, Chowdhury, M, Chu, D, Coelho, C, Cook, A, Damiani, G, Daoud, F, Gela, J, Darwish, A, Daryani, A, Das, J, Davis Weaver, N, Deribe, K, Desalew, A, Dharmaratne, S, Dianatinasab, M, Diaz, D, Djalalinia, S, Dorostkar, F, Dubljanin, E, Duko, B, Dwyer-Lindgren, L, Effiong, A, El Sayed Zaki, M, El Tantawi, M, Enany, S, Fattahi, N, Feigin, V, Fernandes, E, Ferrara, P, Fischer, F, Foigt, N, Folayan, M, Foroutan, M, Frostad, J, Fukumoto, T, Gaidhane, A, Gebrekrstos, H, Gebremeskel, L, Gebreslassie, A, Gething, P, Gezae, K, Ghadiri, K, Ghashghaee, A, Golechha, M, Gubari, M, Hadgu, F, Hamidi, S, Handiso, D, Hashi, A, Hassan, S, Hayat, K, Herteliu, C, Ho, H, Holla, R, Hosseinzadeh, M, Househ, M, Hussain, R, Hwang, B, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Irvani, S, Jaafari, J, Javaheri, T, Jha, R, Johnson, K, Jonas, J, Jozwiak, J, Kabir, A, Kalhor, R, Kanchan, T, Karch, A, Kayode, G, Keiyoro, P, Khader, Y, Khalil, I, Khan, M, Khan, G, Khatab, K, Khater, M, Khatib, M, Kianipour, N, Kim, Y, Kimokoti, R, Kisa, S, Kisa, A, Kissoon, N, Kochhar, S, Koolivand, A, Kopec, J, Koyanagi, A, Krishan, K, Kumar, P, Kurmi, O, Kusuma, D, Lal, D, Lami, F, Landires, I, Lansingh, V, Lasrado, S, La Vecchia, C, Lazzar-Atwood, A, Lee, P, Legrand, K, Lewycka, S, Li, B, Lim, S, Lindstedt, P, Liu, X, Longbottom, J, Lopez, A, Magdy Abd El Razek, H, Mahasha, P, Maleki, A, Mamun, A, Mansournia, M, Marczak, L, Martins-Melo, F, Mayala, B, Meharie, B, Melese, A, Mendoza, W, Menezes, R, Mengesha, E, Mensah, G, Meretoja, T, Mestrovic, T, Miller, T, Mirrakhimov, E, Moazen, B, Mohammad Gholi Mezerji, N, Mohammadi, S, Mohammed, S, Mokdad, A, Moradi, M, Moradzadeh, R, Moraga, P, Mosser, J, Murray, C, Naderi, M, Nagarajan, A, Nazari, J, Ndejjo, R, Negoi, I, Ngunjiri, J, Nguyen, Q, Nguyen, H, Nnaji, C, Noubiap, J, Nunez-Samudio, V, Olagunju, A, Olusanya, J, Olusanya, B, Omer, M, Onwujekwe, O, Otstavnov, N, Otstavnov, S, Owolabi, M, P A, M, Padubidri, J, Pana, A, Peprah, E, Pham, H, Pigott, D, Pirestani, M, Postma, M, Pottoo, F, Pourjafar, H, Quazi Syed, Z, Rahim, F, Rahimi-Movaghar, V, Rahman, M, Rao, S, Rao, P, Rathi, P, Rawaf, S, Rawaf, D, Rawal, L, Rawassizadeh, R, Regassa, L, Renzaho, A, Rezaei, N, Rezai, M, Ribeiro, A, Rickard, J, Rios-Gonzalez, C, Rumisha, S, Sabour, S, Sajadi, S, Salomon, J, Samadi Kafil, H, Samy, A, Sanabria, J, Sartorius, B, Saxena, D, Schaeffer, L, Senthilkumaran, S, Sha, F, Shaheen, A, Shaikh, M, Sharma, R, Sheikh, A, Shibuya, K, Shigematsu, M, Il Shin, J, Simonetti, B, Singh, J, Smith, D, Soheili, A, Sokhan, A, Spurlock, E, Sreeramareddy, C, Sufiyan, M, Swartz, S, Tadesse, D, Tamiru, A, Tefera, Y, Temsah, M, Tessema, Z, Titova, M, Tran, B, Truong, P, Unnikrishnan, B, Upadhyay, E, Vasankari, T, Vasseghian, Y, Violante, F, Vu, G, Waheed, Y, Wamai, R, Wassie, E, Welay, F, Wickramasinghe, N, Wiens, K, Wijeratne, T, Wiysonge, C, Wondmeneh, T, Yamada, T, Yaya, S, Yeshitila, Y, Yip, P, Yonemoto, N, Yu, C, Yuce, D, Yusefzadeh, H, Zaidi, Z, Zamanian, M, Zangeneh, A, Zhang, Z, Zhang, Y, Ziapour, A, Hay, S, Reiner R. C., Welgan C. A., Troeger C. E., Baumann M. M., Weiss D. J., Deshpande A., Blacker B. F., Miller-Petrie M. K., Earl L., Bhatt S., Abolhassani H., Abosetugn A. E., Abu-Gharbieh E., Adekanmbi V., Adetokunboh O. O., Aghaali M., Aji B., Alahdab F., Al-Aly Z., Alhassan R. K., Ali S., Alizade H., Aljunid S. M., Almasi-Hashiani A., Al-Mekhlafi H. M., Altirkawi K. A., Alvis-Guzman N., Amare A. T., Amini S., Amugsi D. A., Ancuceanu R., Andrei C. L., Ansari F., Anvari D., Appiah S. C. Y., Arabloo J., Aremu O., Atout M. M. W., Ausloos M., Ausloos F., Ayanore M. A., Aynalem Y. A., Azene Z. N., Badawi A., Baig A. A., Banach M., Bedi N., Bhagavathula A. S., Bhandari D., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bhutta Z. A., Bijani A., Birhanu T. T. M., Bitew Z. W., Boloor A., Brady O. J., Butt Z. A., Car J., Carvalho F., Casey D. C., Chattu V. K., Chowdhury M. A. K., Chu D. -T., Coelho C. H., Cook A. J., Damiani G., Daoud F., Gela J. D., Darwish A. H., Daryani A., Das J. K., Davis Weaver N., Deribe K., Desalew A., Dharmaratne S. D., Dianatinasab M., Diaz D., Djalalinia S., Dorostkar F., Dubljanin E., Duko B., Dwyer-Lindgren L., Effiong A., El Sayed Zaki M., El Tantawi M., Enany S., Fattahi N., Feigin V. L., Fernandes E., Ferrara P., Fischer F., Foigt N. A., Folayan M. O., Foroutan M., Frostad J. J., Fukumoto T., Gaidhane A. M., Gebrekrstos H. G. G. K., Gebremeskel L., Gebreslassie A. A., Gething P. W., Gezae K. E., Ghadiri K., Ghashghaee A., Golechha M., Gubari M. I. M., Hadgu F. B., Hamidi S., Handiso D. W., Hashi A., Hassan S., Hayat K., Herteliu C., Ho H. C., Holla R., Hosseinzadeh M., Househ M., Hussain R., Hwang B. -F., Ibitoye S. E., Ilesanmi O. S., Ilic I. M., Ilic M. D., Irvani S. S. N., Jaafari J., Javaheri T., Jha R. P., Johnson K. B., Jonas J. B., Jozwiak J. J., Kabir A., Kalhor R., Kanchan T., Karch A., Kayode G. A., Keiyoro P. N., Khader Y. S., Khalil I. A., Khan M. N., Khan M., Khan G., Khatab K., Khater M. M., Khatib M. N., Kianipour N., Kim Y. J., Kimokoti R. W., Kisa S., Kisa A., Kissoon N., Kochhar S., Koolivand A., Kopec J. A., Koyanagi A., Krishan K., Kumar P., Kurmi O. P., Kusuma D., Lal D. K., Lami F. H., Landires I., Lansingh V. C., Lasrado S., La Vecchia C., Lazzar-Atwood A., Lee P. H., LeGrand K. E., Lewycka S., Li B., Lim S. S., Lindstedt P. A., Liu X., Longbottom J., Lopez A. D., Magdy Abd El Razek H., Mahasha P. W., Maleki A., Mamun A. A., Mansournia M. A., Marczak L. B., Martins-Melo F. R., Mayala B. K., Meharie B. G., Melese A., Mendoza W., Menezes R. G., Mengesha E. W., Mensah G. A., Meretoja T. J., Mestrovic T., Miller T. R., Mirrakhimov E. M., Moazen B., Mohammad Gholi Mezerji N., Mohammadi S., Mohammed S., Mokdad A. H., Moradi M., Moradzadeh R., Moraga P., Mosser J. F., Murray C. J. L., Naderi M., Nagarajan A. J., Nazari J., Ndejjo R., Negoi I., Ngunjiri J. W., Nguyen Q. A. P., Nguyen H. L. T., Nnaji C. A., Noubiap J. J., Nunez-Samudio V., Olagunju A. T., Olusanya J. O., Olusanya B. O., Omer M. O., Onwujekwe O. E., Otstavnov N., Otstavnov S. S., Owolabi M. O., P A M., Padubidri J. R., Pana A., Peprah E. K., Pham H. Q., Pigott D. M., Pirestani M., Postma M. J., Pottoo F. H., Pourjafar H., Quazi Syed Z., Rahim F., Rahimi-Movaghar V., Rahman M. H. U., Rao S. J., Rao P. C., Rathi P., Rawaf S., Rawaf D. L., Rawal L., Rawassizadeh R., Regassa L. D., Renzaho A. M. N., Rezaei N., Rezai M. S., Ribeiro A. I., Rickard J., Rios-Gonzalez C. M., Rumisha S. F., Sabour S., Sajadi S. M., Salomon J. A., Samadi Kafil H., Samy A. M., Sanabria J., Sartorius B., Saxena D., Schaeffer L. E., Senthilkumaran S., Sha F., Shaheen A. A., Shaikh M. A., Sharma R., Sheikh A., Shibuya K., Shigematsu M., Il Shin J., Simonetti B., Singh J. A., Smith D. L., Soheili A., Sokhan A., Spurlock E. E., Sreeramareddy C. T., Sufiyan M. B., Swartz S. J., Tadesse D. B., Tamiru A. T., Tefera Y. G., Temsah M. -H., Tessema Z. T., Titova M. V., Tran B. X., Truong P. N., Unnikrishnan B., Upadhyay E., Vasankari T. J., Vasseghian Y., Violante F. S., Vu G. T., Waheed Y., Wamai R. G., Wassie E. G., Welay F. T., Wickramasinghe N. D., Wiens K. E., Wijeratne T., Wiysonge C. S., Wondmeneh T. G., Yamada T., Yaya S., Yeshitila Y. G., Yip P., Yonemoto N., Yu C., Yuce D., Yusefzadeh H., Zaidi Z., Zamanian M., Zangeneh A., Zhang Z. -J., Zhang Y., Ziapour A., Hay S. I., Reiner, R, Welgan, C, Troeger, C, Baumann, M, Weiss, D, Deshpande, A, Blacker, B, Miller-Petrie, M, Earl, L, Bhatt, S, Abolhassani, H, Abosetugn, A, Abu-Gharbieh, E, Adekanmbi, V, Adetokunboh, O, Aghaali, M, Aji, B, Alahdab, F, Al-Aly, Z, Alhassan, R, Ali, S, Alizade, H, Aljunid, S, Almasi-Hashiani, A, Al-Mekhlafi, H, Altirkawi, K, Alvis-Guzman, N, Amare, A, Amini, S, Amugsi, D, Ancuceanu, R, Andrei, C, Ansari, F, Anvari, D, Appiah, S, Arabloo, J, Aremu, O, Atout, M, Ausloos, M, Ausloos, F, Ayanore, M, Aynalem, Y, Azene, Z, Badawi, A, Baig, A, Banach, M, Bedi, N, Bhagavathula, A, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhutta, Z, Bijani, A, Birhanu, T, Bitew, Z, Boloor, A, Brady, O, Butt, Z, Car, J, Carvalho, F, Casey, D, Chattu, V, Chowdhury, M, Chu, D, Coelho, C, Cook, A, Damiani, G, Daoud, F, Gela, J, Darwish, A, Daryani, A, Das, J, Davis Weaver, N, Deribe, K, Desalew, A, Dharmaratne, S, Dianatinasab, M, Diaz, D, Djalalinia, S, Dorostkar, F, Dubljanin, E, Duko, B, Dwyer-Lindgren, L, Effiong, A, El Sayed Zaki, M, El Tantawi, M, Enany, S, Fattahi, N, Feigin, V, Fernandes, E, Ferrara, P, Fischer, F, Foigt, N, Folayan, M, Foroutan, M, Frostad, J, Fukumoto, T, Gaidhane, A, Gebrekrstos, H, Gebremeskel, L, Gebreslassie, A, Gething, P, Gezae, K, Ghadiri, K, Ghashghaee, A, Golechha, M, Gubari, M, Hadgu, F, Hamidi, S, Handiso, D, Hashi, A, Hassan, S, Hayat, K, Herteliu, C, Ho, H, Holla, R, Hosseinzadeh, M, Househ, M, Hussain, R, Hwang, B, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Irvani, S, Jaafari, J, Javaheri, T, Jha, R, Johnson, K, Jonas, J, Jozwiak, J, Kabir, A, Kalhor, R, Kanchan, T, Karch, A, Kayode, G, Keiyoro, P, Khader, Y, Khalil, I, Khan, M, Khan, G, Khatab, K, Khater, M, Khatib, M, Kianipour, N, Kim, Y, Kimokoti, R, Kisa, S, Kisa, A, Kissoon, N, Kochhar, S, Koolivand, A, Kopec, J, Koyanagi, A, Krishan, K, Kumar, P, Kurmi, O, Kusuma, D, Lal, D, Lami, F, Landires, I, Lansingh, V, Lasrado, S, La Vecchia, C, Lazzar-Atwood, A, Lee, P, Legrand, K, Lewycka, S, Li, B, Lim, S, Lindstedt, P, Liu, X, Longbottom, J, Lopez, A, Magdy Abd El Razek, H, Mahasha, P, Maleki, A, Mamun, A, Mansournia, M, Marczak, L, Martins-Melo, F, Mayala, B, Meharie, B, Melese, A, Mendoza, W, Menezes, R, Mengesha, E, Mensah, G, Meretoja, T, Mestrovic, T, Miller, T, Mirrakhimov, E, Moazen, B, Mohammad Gholi Mezerji, N, Mohammadi, S, Mohammed, S, Mokdad, A, Moradi, M, Moradzadeh, R, Moraga, P, Mosser, J, Murray, C, Naderi, M, Nagarajan, A, Nazari, J, Ndejjo, R, Negoi, I, Ngunjiri, J, Nguyen, Q, Nguyen, H, Nnaji, C, Noubiap, J, Nunez-Samudio, V, Olagunju, A, Olusanya, J, Olusanya, B, Omer, M, Onwujekwe, O, Otstavnov, N, Otstavnov, S, Owolabi, M, P A, M, Padubidri, J, Pana, A, Peprah, E, Pham, H, Pigott, D, Pirestani, M, Postma, M, Pottoo, F, Pourjafar, H, Quazi Syed, Z, Rahim, F, Rahimi-Movaghar, V, Rahman, M, Rao, S, Rao, P, Rathi, P, Rawaf, S, Rawaf, D, Rawal, L, Rawassizadeh, R, Regassa, L, Renzaho, A, Rezaei, N, Rezai, M, Ribeiro, A, Rickard, J, Rios-Gonzalez, C, Rumisha, S, Sabour, S, Sajadi, S, Salomon, J, Samadi Kafil, H, Samy, A, Sanabria, J, Sartorius, B, Saxena, D, Schaeffer, L, Senthilkumaran, S, Sha, F, Shaheen, A, Shaikh, M, Sharma, R, Sheikh, A, Shibuya, K, Shigematsu, M, Il Shin, J, Simonetti, B, Singh, J, Smith, D, Soheili, A, Sokhan, A, Spurlock, E, Sreeramareddy, C, Sufiyan, M, Swartz, S, Tadesse, D, Tamiru, A, Tefera, Y, Temsah, M, Tessema, Z, Titova, M, Tran, B, Truong, P, Unnikrishnan, B, Upadhyay, E, Vasankari, T, Vasseghian, Y, Violante, F, Vu, G, Waheed, Y, Wamai, R, Wassie, E, Welay, F, Wickramasinghe, N, Wiens, K, Wijeratne, T, Wiysonge, C, Wondmeneh, T, Yamada, T, Yaya, S, Yeshitila, Y, Yip, P, Yonemoto, N, Yu, C, Yuce, D, Yusefzadeh, H, Zaidi, Z, Zamanian, M, Zangeneh, A, Zhang, Z, Zhang, Y, Ziapour, A, Hay, S, Reiner R. C., Welgan C. A., Troeger C. E., Baumann M. M., Weiss D. J., Deshpande A., Blacker B. F., Miller-Petrie M. K., Earl L., Bhatt S., Abolhassani H., Abosetugn A. E., Abu-Gharbieh E., Adekanmbi V., Adetokunboh O. O., Aghaali M., Aji B., Alahdab F., Al-Aly Z., Alhassan R. K., Ali S., Alizade H., Aljunid S. M., Almasi-Hashiani A., Al-Mekhlafi H. M., Altirkawi K. A., Alvis-Guzman N., Amare A. T., Amini S., Amugsi D. A., Ancuceanu R., Andrei C. L., Ansari F., Anvari D., Appiah S. C. Y., Arabloo J., Aremu O., Atout M. M. W., Ausloos M., Ausloos F., Ayanore M. A., Aynalem Y. A., Azene Z. N., Badawi A., Baig A. A., Banach M., Bedi N., Bhagavathula A. S., Bhandari D., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bhutta Z. A., Bijani A., Birhanu T. T. M., Bitew Z. W., Boloor A., Brady O. J., Butt Z. A., Car J., Carvalho F., Casey D. C., Chattu V. K., Chowdhury M. A. K., Chu D. -T., Coelho C. H., Cook A. J., Damiani G., Daoud F., Gela J. D., Darwish A. H., Daryani A., Das J. K., Davis Weaver N., Deribe K., Desalew A., Dharmaratne S. D., Dianatinasab M., Diaz D., Djalalinia S., Dorostkar F., Dubljanin E., Duko B., Dwyer-Lindgren L., Effiong A., El Sayed Zaki M., El Tantawi M., Enany S., Fattahi N., Feigin V. L., Fernandes E., Ferrara P., Fischer F., Foigt N. A., Folayan M. O., Foroutan M., Frostad J. J., Fukumoto T., Gaidhane A. M., Gebrekrstos H. G. G. K., Gebremeskel L., Gebreslassie A. A., Gething P. W., Gezae K. E., Ghadiri K., Ghashghaee A., Golechha M., Gubari M. I. M., Hadgu F. B., Hamidi S., Handiso D. W., Hashi A., Hassan S., Hayat K., Herteliu C., Ho H. C., Holla R., Hosseinzadeh M., Househ M., Hussain R., Hwang B. -F., Ibitoye S. E., Ilesanmi O. S., Ilic I. M., Ilic M. D., Irvani S. S. N., Jaafari J., Javaheri T., Jha R. P., Johnson K. B., Jonas J. B., Jozwiak J. J., Kabir A., Kalhor R., Kanchan T., Karch A., Kayode G. A., Keiyoro P. N., Khader Y. S., Khalil I. A., Khan M. N., Khan M., Khan G., Khatab K., Khater M. M., Khatib M. N., Kianipour N., Kim Y. J., Kimokoti R. W., Kisa S., Kisa A., Kissoon N., Kochhar S., Koolivand A., Kopec J. A., Koyanagi A., Krishan K., Kumar P., Kurmi O. P., Kusuma D., Lal D. K., Lami F. H., Landires I., Lansingh V. C., Lasrado S., La Vecchia C., Lazzar-Atwood A., Lee P. H., LeGrand K. E., Lewycka S., Li B., Lim S. S., Lindstedt P. A., Liu X., Longbottom J., Lopez A. D., Magdy Abd El Razek H., Mahasha P. W., Maleki A., Mamun A. A., Mansournia M. A., Marczak L. B., Martins-Melo F. R., Mayala B. K., Meharie B. G., Melese A., Mendoza W., Menezes R. G., Mengesha E. W., Mensah G. A., Meretoja T. J., Mestrovic T., Miller T. R., Mirrakhimov E. M., Moazen B., Mohammad Gholi Mezerji N., Mohammadi S., Mohammed S., Mokdad A. H., Moradi M., Moradzadeh R., Moraga P., Mosser J. F., Murray C. J. L., Naderi M., Nagarajan A. J., Nazari J., Ndejjo R., Negoi I., Ngunjiri J. W., Nguyen Q. A. P., Nguyen H. L. T., Nnaji C. A., Noubiap J. J., Nunez-Samudio V., Olagunju A. T., Olusanya J. O., Olusanya B. O., Omer M. O., Onwujekwe O. E., Otstavnov N., Otstavnov S. S., Owolabi M. O., P A M., Padubidri J. R., Pana A., Peprah E. K., Pham H. Q., Pigott D. M., Pirestani M., Postma M. J., Pottoo F. H., Pourjafar H., Quazi Syed Z., Rahim F., Rahimi-Movaghar V., Rahman M. H. U., Rao S. J., Rao P. C., Rathi P., Rawaf S., Rawaf D. L., Rawal L., Rawassizadeh R., Regassa L. D., Renzaho A. M. N., Rezaei N., Rezai M. S., Ribeiro A. I., Rickard J., Rios-Gonzalez C. M., Rumisha S. F., Sabour S., Sajadi S. M., Salomon J. A., Samadi Kafil H., Samy A. M., Sanabria J., Sartorius B., Saxena D., Schaeffer L. E., Senthilkumaran S., Sha F., Shaheen A. A., Shaikh M. A., Sharma R., Sheikh A., Shibuya K., Shigematsu M., Il Shin J., Simonetti B., Singh J. A., Smith D. L., Soheili A., Sokhan A., Spurlock E. E., Sreeramareddy C. T., Sufiyan M. B., Swartz S. J., Tadesse D. B., Tamiru A. T., Tefera Y. G., Temsah M. -H., Tessema Z. T., Titova M. V., Tran B. X., Truong P. N., Unnikrishnan B., Upadhyay E., Vasankari T. J., Vasseghian Y., Violante F. S., Vu G. T., Waheed Y., Wamai R. G., Wassie E. G., Welay F. T., Wickramasinghe N. D., Wiens K. E., Wijeratne T., Wiysonge C. S., Wondmeneh T. G., Yamada T., Yaya S., Yeshitila Y. G., Yip P., Yonemoto N., Yu C., Yuce D., Yusefzadeh H., Zaidi Z., Zamanian M., Zangeneh A., Zhang Z. -J., Zhang Y., Ziapour A., and Hay S. I.

Abstract

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.

Published
2022

32. Coding of time with non-linear mixed selectivity in Prefrontal Cortex ensembles

Author

Catherine A. Mikkelsen, Stephen J. Charczynski, Scott K. Brincat, Melissa R. Warden, Earl L. Miller, and Marc W. Howard

Abstract

Previous work has identified stimulus specific time cells as a potential mechanism for working memory maintenance. It has been proposed that populations of stimulus specific sequences of cells could support memory for many items in a list over long periods of time. This would require information about one stimulus to persist after the presentation of subsequent stimuli. However, it is not known if sequences triggered by one stimulus persist past the presentation of additional stimuli. It is possible that each new stimulus terminates preceding sequences, making memory for multiple stimuli impossible. To investigate this question, we utilized a data set originally published by (Warden & Miller, 2010), studying the firing of monkey prefrontal neurons during short lists of stimuli. We were able to decode “what happened when” throughout the list, using linear discriminant analysis. Additionally, we were able to decode the first stimulus after the presentation of the second stimulus. Furthermore, we found that stimulus modulated sequences of cells, with discrete temporal fields, continue after the second item was presented. Much of the information about the previous item was carried by neurons that responded to conjunctions of stimuli and the timing of late-firing cells was synchronized to the firing of the second stimulus rather than the first. These properties falsify a simple linear model of sequential time cells. These results suggest that non-linear mixed selectivity extends to continuous variables such as time, but that in this experiment at least, only the timing of the most recent stimulus was explicitly maintained in ongoing firing.

Published
2023

34. Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis

Author

Sorensen, Rjd, Barber, Rm, Pigott, Dm, Carter, A, Spencer, Cn, Ostroff, Sm, Reiner, Rc, Abbafati, C, Adolph, C, Allorant, A, Amlag, Jo, Aravkin, Ay, Bachmeier, Sd, Bang-Jensen, Bl, Bisignano, C, Bloom, Ss, Castellano, R, Castro, E, Collins, Jk, Comfort, H, Dai, Xc, Dangel, Wj, Dapper, C, Deen, A, Earl, L, Erickson, M, Ewald, Sb, Ferrari, Aj, Flaxman, Ad, Frostad, Jj, Fullman, N, Gamkrelidze, A, Giles, Jr, Guo, Gr, Jw, He, Helak, M, Hulland, En, Huntley, Bm, Kereselidze, M, Lazzar-Atwood, A, Legrand, Ke, Lindstrom, A, Linebarger, E, Lozano, R, Magistro, B, Malta, Dc, Mansson, J, Herrera, Amm, Marinho, F, Mirkuzie, Ah, Mokdad, Ah, Monasta, L, Naghavi, M, Nassereldine, H, Nomura, S, Odell, Cm, Olana, Lt, Pasovic, M, Pease, Sa, Penberthy, L, Reinke, G, Ribeiro, Alp, Santomauro, Df, Sholokhov, A, Skhvitaridze, N, Spurlock, Ee, Syailendrawati, R, Topor-Madry, R, At, Vo, Vos, T, Walcott, R, Walker, A, Watson, S, Wiysonge, Cs, Worku, Na, Zheng, P, Hay, Si, Gakidou, E, and Murray, Cjl

Subjects
infection fatality ratio, covid, General Medicine, vaccination
Published
2022

35. Measurements of He-Ar, He-N2, and He-air thermal creep slip and accommodation coefficients at high temperatures.

Author

Wilson, Jason, Walton, Kyle L., Tipton, Earl L., Ghosh, Tushar K., Tompson, Robert V., and Loyalka, Sudarshan K.

Subjects
HIGH temperatures, CAPILLARY flow, GAS flow, CAPILLARIES, STAINLESS steel
Abstract

Understanding gas flows in capillaries has many applications in modeling the transport of gases in nano-structured, porous, or fractured media. A network of capillaries can often approximate these media, and also information on gas-surface interactions obtained from capillary experiments can be used for modeling flows in these media. Experimental data on flows of different mixtures of He-Ar, He-N2, and He-air in the slip regime and in stainless steel capillaries at high temperatures were obtained by using a two-bulb apparatus. An accurate expression for the thermal creep slip coefficients with the Lennard-Jones potential parameters and diffuse-specular reflection gas-surface interaction conditions were then used to obtain the accommodation coefficients for the different gases. The experimental data are best described with values of accommodation coefficients in the range of 0.1–0.3 for He and 0.5–1.0 for Ar, N2, and air. The use of values in this range is suggested for modeling gaseous flows in capillaries and nano-structured, porous, or fractured media if other direct measured values for a particular medium are unavailable. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
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38. The Standardized Growth Expectation: Implications for Education Evaluation

Author

A. Jackson Stenner, June D. Bland, Earl L. Hunter, and Mildred L. Cooper

Abstract

The purpose of this paper is to review some assumptions underlying the use of norm-referenced tests in educational evaluations and to provide a prospectus for research on these assumptions as well as other questions related to norm-referenced tests. Specifically, the assumptions which will be examined are (1) expressing treatment effects in a standard score metric permits aggregation of effects across grades, (2) commonly used standardized tests are sufficiently comparable to permit aggregation of results across tests, and (3) the summer loss observed in Title I projects is due to an actual loss in achievement skills and knowledge. We wish to emphasize at the outset that our intent in this paper is to raise questions and not to present a coherent set of answers.

Published
2022

41. Electrochemical Reduction of CO2 to Oxalic Acid: Experiments, Process Modeling, and Economics

Author

Boor, Vera, primary, Frijns, Jeannine E. B. M., additional, Perez-Gallent, Elena, additional, Giling, Erwin, additional, Laitinen, Antero T., additional, Goetheer, Earl L. V., additional, van den Broeke, Leo J. P., additional, Kortlever, Ruud, additional, de Jong, Wiebren, additional, Moultos, Othonas A., additional, Vlugt, Thijs J. H., additional, and Ramdin, Mahinder, additional

Published
2022
Full Text
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42. Electrochemical Reduction of CO

Author

Vera, Boor, Jeannine E B M, Frijns, Elena, Perez-Gallent, Erwin, Giling, Antero T, Laitinen, Earl L V, Goetheer, Leo J P, van den Broeke, Ruud, Kortlever, Wiebren, de Jong, Othonas A, Moultos, Thijs J H, Vlugt, and Mahinder, Ramdin

Abstract

We performed H-cell and flow cell experiments to study the electrochemical reduction of CO

Published
2022

44. The prevalence of onchocerciasis in Africa and Yemen, 2000-2018: a geospatial analysis

Author

Schmidt, CA, Cromwell, EA, Hill, E, Donkers, KM, Schipp, MF, Johnson, KB, Pigott, DM, Abbas, J, Adekanmbi, V, Adetokunboh, OO, Ahmed, MB, Alanezi, FM, Alanzi, TM, Alipour, V, Andrei, CL, Andrei, T, Anvari, D, Appiah, SCY, Aqeel, M, Arabloo, J, Jafarabadi, MA, Ausloos, M, Baig, AA, Banach, M, Bärnighausen, TW, Bhattacharyya, K, Bhutta, ZA, Bijani, A, Brady, OJ, Bragazzi, NL, Butt, ZA, Carvalho, F, Chattu, VK, Dahlawi, SMA, Damiani, G, Demeke, FM, Deribe, K, Dharmaratne, SD, Diaz, D, Didarloo, A, Earl, L, Zaki, MES, El Tantawi, M, Fattahi, N, Fernandes, E, Foigt, NA, Foroutan, M, Franklin, RC, Guo, Y, Haj-Mirzaian, A, Hamidi, S, Hassankhani, H, Herteliu, C, Higazi, TB, Hosseini, M, Hosseinzadeh, M, Househ, M, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irvani, SSN, Jha, RP, Ji, JS, Jonas, JB, Jozwiak, JJ, Kalankesh, LR, Kamyari, N, Matin, BK, Karimi, SE, Kayode, GA, Karyani, AK, Khan, EA, Khan, MN, Khatab, K, Khater, MM, Kianipour, N, Kim, YJ, Kosen, S, Kusuma, D, La Vecchia, C, Lansingh, VC, Lee, PH, Li, S, Maleki, S, Mansournia, MA, Martins-Melo, FR, McAlinden, C, Mendoza, W, Mestrovic, T, Moghadaszadeh, M, Mohammadian-Hafshejani, A, Mohammadi, SM, Mohammed, S, Moradzadeh, R, Moraga, P, Naderi, M, Nagarajan, AJ, Negoi, I, Nguyen, CT, Nguyen, HLT, Oancea, B, Olagunju, AT, Bali, AO, Onwujekwe, OE, Pana, A, Rahimi-Movaghar, V, Ramezanzadeh, K, Rawaf, DL, Rawaf, S, Rawassizadeh, R, Rezapour, A, Ribeiro, AI, Samy, AM, Shaikh, MA, Sharafi, K, Sheikh, A, Singh, JA, Skiadaresi, E, Soltani, S, Stolk, WA, Sufiyan, MB, Thomson, AJ, Tran, BX, Tran, KB, Unnikrishnan, B, Violante, FS, Vu, GT, Yamada, T, Yaya, S, Yip, P, Yonemoto, N, Yu, C, Yu, Y, Zamanian, M, Zhang, Y, Zhang, Z-J, Ziapour, A, and Hay, SI

Subjects
Onchocerciasis, Geospatial model, Neglected tropical diseases, Ivermectin, Yemen, Settore MED/06 - Oncologia Medica, Settore MED/42 - Igiene Generale e Applicata, Nigeria, Bayes Theorem, General Medicine, Ghana, Settore MED/01 - Statistica Medica, General & Internal Medicine, Prevalence, Humans, 11 Medical and Health Sciences
Abstract

Background Onchocerciasis is a disease caused by infection with Onchocerca volvulus, which is transmitted to humans via the bite of several species of black fly, and is responsible for permanent blindness or vision loss, as well as severe skin disease. Predominantly endemic in parts of Africa and Yemen, preventive chemotherapy with mass drug administration of ivermectin is the primary intervention recommended for the elimination of its transmission. Methods A dataset of 18,116 geo-referenced prevalence survey datapoints was used to model annual 2000–2018 infection prevalence in Africa and Yemen. Using Bayesian model-based geostatistics, we generated spatially continuous estimates of all-age 2000–2018 onchocerciasis infection prevalence at the 5 × 5-km resolution as well as aggregations to the national level, along with corresponding estimates of the uncertainty in these predictions. Results As of 2018, the prevalence of onchocerciasis infection continues to be concentrated across central and western Africa, with the highest mean estimates at the national level in Ghana (12.2%, 95% uncertainty interval [UI] 5.0–22.7). Mean estimates exceed 5% infection prevalence at the national level for Cameroon, Central African Republic, Democratic Republic of the Congo (DRC), Guinea-Bissau, Sierra Leone, and South Sudan. Conclusions Our analysis suggests that onchocerciasis infection has declined over the last two decades throughout western and central Africa. Focal areas of Angola, Cameroon, the Democratic Republic of the Congo, Ethiopia, Ghana, Guinea, Mali, Nigeria, South Sudan, and Uganda continue to have mean microfiladermia prevalence estimates exceeding 25%. At and above this level, the continuation or initiation of mass drug administration with ivermectin is supported. If national programs aim to eliminate onchocerciasis infection, additional surveillance or supervision of areas of predicted high prevalence would be warranted to ensure sufficiently high coverage of program interventions.

Published
2022

45. Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018.

Author

Kinyoki D., Osgood-Zimmerman A.E., Bhattacharjee N.V., Schaeffer L.E., Lazzar-Atwood A., Lu D., Ewald S.B., Donkers K.M., Letourneau I.D., Collison M., Schipp M.F., Abajobir A., Abbasi S., Abbasi N., Abbasifard M., Abbasi-Kangevari M., Abbastabar H., Abd-Allah F., Abdelalim A., Abd-Elsalam S.M., Abdoli A., Abdollahpour I., Abedi A., Abolhassani H., Abraham B., Abreu L.G., Abrigo M.R.M., Abualhasan A., Abu-Gharbieh E., Abushouk A.I., Accrombessi M.M.K., Adabi M., Adebayo O.M., Adegbosin A.E., Adekanmbi V., Adetokunboh O.O., Adeyinka D.A., Adham D., Advani S.M., Agasthi P., Aghaali M., Ahmad S., Ahmad T., Ahmadi K., Ahmadi S., Ahmed M.B., Aichour M.T.E., Aji B., Akinyemi O.O., Aklilu A., Akunna C.J., Al-Aly Z., Alanzi T.M., Alcalde-Rabanal J.E., Alemu B.W., Alemu A., Alhassan R.K., Alif S.M., Alipour V., Alizade H., Aljunid S.M., Almasi-Hashiani A., Al-Mekhlafi H.M., Al-Raddadi R.M., Alvis-Guzman N., Amini S., Amiri F., Amugsi D.A., Anber N.H., Ancuceanu R., Andrei T., Anegago M.T., Anjomshoa M., Ansari F., Ansari-Moghaddam A., Anteneh Z.A., Antriyandarti E., Anvari D., Anwer R., Aqeel M., Arabloo J., Arab-Zozani M., Aremu O., Areri H.A., Artaman A., Arzani A., Asaad M., Asadi-Aliabadi M., Asadi-Pooya A.A., Asemahagn M.A., Asghari Jafarabadi M., Ashebir M.M., Ataro Z., Athari S.M., Athari S.S., Atout M.M.W., Ausloos M., Awoke N., Ayala Quintanilla B.P., Ayano G., Ayanore M.A., Aynalem Y.A., Ayza M.A., Azadmehr A., B D., Babalola T.K., Badawi A., Badiye A.D., Bahrami M.A., Bairwa M., Bakkannavar S.M., Banik P.C., Baraki A.G., Barboza M.A., Basaleem H., Basu S., Bayati M., Baye B.A., Bazmandegan G., Bedi N., Bekuma T.T.T., Bell M.L., Bensenor I.M., Berhe K., Berhe A.K., Berhie K.A., Bhandari D., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bhattarai S., Bhutta Z.A., Bijani A., Bikbov B., Biondi A., Birhanu M., Biswas R.K., Bockarie M.J., Bohlouli S., Bohluli M., Boloor A., Borzouei S., Bragazzi N.L., Braithwaite D., Brunoni A.R., Burugina Nagaraja S., Butt Z.A., Caetano dos Santos F.L., Camera L.A., Car J., Cardenas R., Carvalho F., Castaldelli-Maia J.M., Castaneda-Orjuela C.A., Castro F., Cevik M., Chanie W.F., Charan J., Chatterjee S., Chattu V.K., Chaturvedi S., Chen S., Chin K.L., Chowdhury M.A.K., Cook A.J., Costa V.M., Cromwell E.A., Dachew B.A., Dagne H., Dagnew B., Dahiru T., Dahlawi S.M.A., Dai H., Dandona L., Dandona R., Daneshpajouhnejad P., Daoud F., Das J.K., Das Gupta R., Dash A.P., Davila-Cervantes C.A., Davletov K., Deeba F., De Neve J.-W., Denova-Gutierrez E., Deribe K., Desalew A., Dessie G.A., Dey S., Dhimal M., Dhungana G.P., Dianatinasab M., Diaz D., Dipeolu I.O., Djalalinia S., Do H.T., Dorostkar F., Doshmangir L., Duko B., Duraes A.R., Earl L., Edinur H.A., Efendi F., Elayedath R., Elema T.B., Elhabashy H.R., El-Jaafary S.I., El Sayed I., El Sayed Zaki M., Elsharkawy A., El-Sherbiny Y.M., El Tantawi M., Endalew D.A., Eshrati B., Eskandari K., Eskandarieh S., Fadhil I., Faraon E.J.A., Fareed M., Faris P.S., Farwati M., Farzadfar F., Fasanmi A.O., Fattahi N., Fauk N.K., Feigin V.L., Feleke B.E., Fereshtehnejad S.-M., Fernandes E., Ferrara P., Foigt N.A., Fomenkov A.A., Foroutan M., Francis J.M., Franklin R.C., Freitas M., Fukumoto T., Gad M.M., Gaidhane A.M., Gayesa R.T., Geberemariyam B.S., Gebregiorgis B.G., Gebremariam H., Gebremariam T.B.B., Gebremeskel L., Gebremeskel G.G., Gebreslassie A.A., Geramo Y.C.D., Gesesew H.A., Gessner B.D., Getacher L., Ghadiri K., Ghaffarifar F., Ghafourifard M., Ghajarzadeh M., Ghamari F., Ghashghaee A., Ghith N., Gilani S.A., Gill T.K., Godinho M.A., Gona P.N., Grada A., Gubari M.I.M., Gudi N., Guido D., Guled R.A., Guo Y., Gupta R., Haj-Mirzaian A., Hamadeh R.R., Handiso D.W., Hanif A., Hargono A., Hasaballah A.I., Hasan M.M., Hasan S.S., Hashemian M., Hashi A., Hassan S., Hassan A., Hassanipour S., Hassankhani H., Hayat K., Hegazy M.I., Heidari-Soureshjani R., Henry N.J., Herteliu C., Heydarpour F., Heydarpour S., Hidru H.D., Hoang C.L., Holla R., Hon J., Hong S.H., Hoogar P., Hosseini S.N., Hosseinzadeh M., Hostiuc M., Hostiuc S., Hotez P.J., Househ M., Huda T.M., Huluko D.H.H., Hussain S.A., Hwang B.-F., Ilesanmi O.S., Ilic I.M., Ilic M.D., Inbaraj L.R., Iqbal U., Islam M.M., Islam S.M.S., Iwu C.J., Iwu C.C.D., Jadidi-Niaragh F., Jahani M.A., Jain V., Jakovljevic M., Jalali A., Jalilian F., Janodia M.D., Javaheri T., Jha R.P., John O., Johnson K.B., Jonas J.B., Jonnagaddala J., Joseph N., Joshi A., Joukar F., Jozwiak J.J., Kabir A., Kabir Z., Kahlon T., Kalankesh L.R., Kalhor R., Kamath A., Kamiab Z., Kanchan T., Kapil U., Kapoor N., Karami Matin B., Karimi S.E., Kasa A.S., Kasahun G.G., Kassa Z.Y., Kassa G.G., Kassahun G., Kayode G.A., Kazemi Karyani A., Keflie T.S., Keiyoro P.N., Kelkay B., Keramati M., Ketema D.B., Khalid N., Khammarnia M., Khan M.N., Khan M., Khan J., Khatab K., Khater A.M., Khater M.M., Khoja A.T., Khubchandani J., Kianipour N., Kim Y.-E., Kim Y.J., Kimokoti R.W., Kisa S., Kisa A., Kolola T., Koolivand A., Kosen S., Koul P.A., Koyanagi A., Krishan K., Krishnamoorthy V., Kuate Defo B., Kugbey N., Kulkarni V., Kumar G.A., Kumar N., Kumar P., Kumar M., Kurmi O.P., Kusuma D., Lacey B., Lad D.P., Lal D.K., Lami F.H., Landires I., Larsson A.O., Lasrado S., Laurens M.B., La Vecchia C., Laxmaiah A., Lee P.H., Lee S.W.H., LeGrand K.E., Lewycka S., Li B., Li S., Liu X., Lopez J.C.F., Machado D.B., Madhava Kunjathur S., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahadeshwara Prasad D.R., Mahasha P.W., Maheri M., Mahotra N.B., Majeed A., Maled V., Maleki S., Malekzadeh R., Malta D.C., Mamun A.A., Mansour-Ghanaei F., Mansouri B., Mansournia M.A., Manzar M.D.D., Marrugo Arnedo C.A., Martins-Melo F.R., Masaka A., Maulik P.K., Mayala B.K., Mehari M., Mehndiratta M.M., Mehrabi Nasab E., Mehri F., Mehta K.M., Meitei W.B., Mekonnen T., Meles G.G., Melku M., Mendoza W., Menezes R.G., Mengesha M.B., Mengesha E.W., Meretoja T.J., Mersha A.M., Metekiya W.M., Miazgowski T., Michalek I.M., Mini G.K., Mir S.A., Mirica A., Mirrakhimov E.M., Mirzaei H., Mirzaei M., Mirzaei-Alavijeh M., Misra S., Moazen B., Moghadaszadeh M., Mohammad Y., Mohammad D.K., Mohammad Gholi Mezerji N., Mohammadi S.M., Mohammadian-Hafshejani A., Mohammadpourhodki R., Mohammed H.M., Mohammed A.S., Mohammed S., Mohammed J.A., Mohseni Bandpei M.A., Mokdad A.H., Molassiotis A., Monasta L., Moradi M., Moradi-Lakeh M., Moradzadeh R., Moraga P., Mosapour A., Mouodi S., Mousavi S.M., Mousavi Khaneghah A., Mulu G.B.B., Munir M., Muriithi M.K., Murthy G.V.S., Mustafa G., Nabhan A.F., Naderi M., Nagarajan A.J., Nagaraju S.P., Naghavi M., Naik G., Naimzada M.D., Nangia V., Nansseu J.R., Naqvi A.A., Nascimento B.R., Nayak S., Nayak V.C., Nazari J., Ndejjo R., Negoi I., Negoi R.I., Netsere H.B., Nguefack-Tsague G., Ngunjiri J.W., Nguyen C.T., Nguyen D.N., Nguyen H.L.T., Nigatu Y.T., Nikbakhsh R., Nikpoor A.R., Nnaji C.A., Nong V.M., Noubiap J.J., Nunez-Samudio V., Nwatah V.E., Nyanhanda T., Oancea B., Ogbo F.A., Oghenetega O.B., Oh I.-H., Okello D.M., Oladnabi M., Olagunju A.T., Olusanya J.O., Olusanya B.O., Bali A.O., Omer M.O., Omonisi A.E.E., Onwujekwe O.E., Ortiz A., Ortiz-Panozo E., Otstavnov N., Otstavnov S.S., Owolabi M.O., Mahesh P.A., Padubidri J.R., Pakhare A.P., Pakshir K., Pana A., Panda-Jonas S., Pandey A., Pandi-Perumal S.R., Pangaribuan H.U., Pasupula D.K., Patel S.K., Patel U.K., Pathak A., Patton G.C., Toroudi H.P., Pereira J., Pescarini J.M., Pham H.Q., Pickering B.V., Pirouzpanah S., Pirsaheb M., Pokhrel K.N., Postma M.J., Pottoo F.H., Pourchamani H., Pourjafar H., Poustchi H., Prada S.I., Pribadi D.R.A., Syed Z.Q., Rabiee N., Rafiee A., Rahim F., Rahman M.H.U., Rahman M.A., Rahmani A.M., Rai R.K., Rajesh A., Ram P., Ramezanzadeh K., Ranabhat C.L., Rao S.J., Rao S., Rastogi P., Rathi P., Rawal L., Rawasia W.F., Rawassizadeh R., Regassa L.D., Reiner R.C., Reshmi B., Rezaei N., Rezahosseini O., Rezapour A., Riahi S.M., Ribeiro D., Ribeiro A.I., Rickard J., Roba H.S., Roever L., Ronfani L., Rostamian M., Rumisha S.F., Rwegerera G.M., Sabour S., Sadeghi E., Saeedi Moghaddam S., Sagar R., Sahebkar A., Sahraian M.A., Sajadi S.M., Salam N., Salem M.R., Kafil H.S., Santos I.S., Santric-Milicevic M.M., Saraswathy S.Y.I., Sarrafzadegan N., Sartorius B., Sarveazad A., Sathian B., Sathish T., Saxena D., Sbarra A.N., Schwebel D.C., Senbeta A.M., Sengupta D., Senthilkumaran S., Sepanlou S.G., Seylani A., Sha F., Shafaat O., Shahabi S., Shahbaz M., Shahid I., Shaikh M.A., Shaka M.F., Shalash A.S., Shamali M., Shams-Beyranvand M., Shamsi M.B., Shamsizadeh M., Shannawaz M., Sharafi K., Sharifi A., Sheikh A., Sheikhtaheri A., Shetty R.S., Shetty B.S.K., Shetty A., Shiferaw W.S., Shigematsu M., Il Shin J., Shiri R., Shirkoohi R., Shivarov V., Siabani S., Malleshappa S.K.S., Siddiqi T.J., Sidemo N.B., Singh B.B., Singh S., Sintayehu Y., Skryabin V.Y., Skryabina A.A., Sobhiyeh M.R., Soheili A., Soltani S., Sorrie M.B., Spurlock E.E., Sreeramareddy C.T., Sudaryanto A., Sufiyan M.B., Sultan I., Tabares-Seisdedos R., Tabuchi T., Taddele B.W., Tadesse E.G., Taherkhani A., Tamir Z., Tamiru A.T., Tareque M.I., Tbakhi A., Teame H., Tefera Y.G., Tehrani-Banihashemi A., Tekalegn Y., Tekle M.G., Teklehaimanot B.F., Temsah M.-H., Tesema G.A., Thankappan K.R., Thomas N., Tiki T., Tilahune A.B., Titova M.V., Tovani-Palone M.R., Tran K.B., Tran B.X., Tripathi R., Tripathy J.P., Truong P.N., Uddin R., Ullah A., Umeokonkwo C.D., Uneke C.J., Unnikrishnan B., Upadhyay E., Usman M.S., Vacante M., Vakilian A., Tahbaz S.V., Valdez P.R., Vasseghian Y., Verma M., Violante F.S., Vo B., Wado Y.D., Waheed Y., Wang Y., Wang Y.-P., Wangdi K., Weldesamuel G.T., Werdecker A., Wiangkham T., Wickramasinghe N.D., Wiysonge C.S., Wonde T.E., Wu A.-M., Wu C., Xie Y., Yadollahpour A., Jabbari S.H.Y., Yamada T., Yang M., Yaya S., Yazdi-Feyzabadi V., Yeheyis T.Y., Yeshaneh A., Yeshaw Y., Yeshitila Y.G., Yilma M.T., Yip P., Young M.F., Yousefi Z., Yousefinezhadi T., Yousof H.-A.S.A., Yousuf A.Y., Yu C., Yu Y., Zafar S., Zaidi S.S., Zaidi Z., Zakzuk J., Bin Zaman S., Zamani M., Zamanian M., Zandifar A., Zangeneh A., Zastrozhin M.S., Zastrozhina A., Zewdie D.T., Zewdie K.A., Zhang Y., Zhu C., Ziapour A., Kassebaum N.J., Hay S.I., Kinyoki D., Osgood-Zimmerman A.E., Bhattacharjee N.V., Schaeffer L.E., Lazzar-Atwood A., Lu D., Ewald S.B., Donkers K.M., Letourneau I.D., Collison M., Schipp M.F., Abajobir A., Abbasi S., Abbasi N., Abbasifard M., Abbasi-Kangevari M., Abbastabar H., Abd-Allah F., Abdelalim A., Abd-Elsalam S.M., Abdoli A., Abdollahpour I., Abedi A., Abolhassani H., Abraham B., Abreu L.G., Abrigo M.R.M., Abualhasan A., Abu-Gharbieh E., Abushouk A.I., Accrombessi M.M.K., Adabi M., Adebayo O.M., Adegbosin A.E., Adekanmbi V., Adetokunboh O.O., Adeyinka D.A., Adham D., Advani S.M., Agasthi P., Aghaali M., Ahmad S., Ahmad T., Ahmadi K., Ahmadi S., Ahmed M.B., Aichour M.T.E., Aji B., Akinyemi O.O., Aklilu A., Akunna C.J., Al-Aly Z., Alanzi T.M., Alcalde-Rabanal J.E., Alemu B.W., Alemu A., Alhassan R.K., Alif S.M., Alipour V., Alizade H., Aljunid S.M., Almasi-Hashiani A., Al-Mekhlafi H.M., Al-Raddadi R.M., Alvis-Guzman N., Amini S., Amiri F., Amugsi D.A., Anber N.H., Ancuceanu R., Andrei T., Anegago M.T., Anjomshoa M., Ansari F., Ansari-Moghaddam A., Anteneh Z.A., Antriyandarti E., Anvari D., Anwer R., Aqeel M., Arabloo J., Arab-Zozani M., Aremu O., Areri H.A., Artaman A., Arzani A., Asaad M., Asadi-Aliabadi M., Asadi-Pooya A.A., Asemahagn M.A., Asghari Jafarabadi M., Ashebir M.M., Ataro Z., Athari S.M., Athari S.S., Atout M.M.W., Ausloos M., Awoke N., Ayala Quintanilla B.P., Ayano G., Ayanore M.A., Aynalem Y.A., Ayza M.A., Azadmehr A., B D., Babalola T.K., Badawi A., Badiye A.D., Bahrami M.A., Bairwa M., Bakkannavar S.M., Banik P.C., Baraki A.G., Barboza M.A., Basaleem H., Basu S., Bayati M., Baye B.A., Bazmandegan G., Bedi N., Bekuma T.T.T., Bell M.L., Bensenor I.M., Berhe K., Berhe A.K., Berhie K.A., Bhandari D., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bhattarai S., Bhutta Z.A., Bijani A., Bikbov B., Biondi A., Birhanu M., Biswas R.K., Bockarie M.J., Bohlouli S., Bohluli M., Boloor A., Borzouei S., Bragazzi N.L., Braithwaite D., Brunoni A.R., Burugina Nagaraja S., Butt Z.A., Caetano dos Santos F.L., Camera L.A., Car J., Cardenas R., Carvalho F., Castaldelli-Maia J.M., Castaneda-Orjuela C.A., Castro F., Cevik M., Chanie W.F., Charan J., Chatterjee S., Chattu V.K., Chaturvedi S., Chen S., Chin K.L., Chowdhury M.A.K., Cook A.J., Costa V.M., Cromwell E.A., Dachew B.A., Dagne H., Dagnew B., Dahiru T., Dahlawi S.M.A., Dai H., Dandona L., Dandona R., Daneshpajouhnejad P., Daoud F., Das J.K., Das Gupta R., Dash A.P., Davila-Cervantes C.A., Davletov K., Deeba F., De Neve J.-W., Denova-Gutierrez E., Deribe K., Desalew A., Dessie G.A., Dey S., Dhimal M., Dhungana G.P., Dianatinasab M., Diaz D., Dipeolu I.O., Djalalinia S., Do H.T., Dorostkar F., Doshmangir L., Duko B., Duraes A.R., Earl L., Edinur H.A., Efendi F., Elayedath R., Elema T.B., Elhabashy H.R., El-Jaafary S.I., El Sayed I., El Sayed Zaki M., Elsharkawy A., El-Sherbiny Y.M., El Tantawi M., Endalew D.A., Eshrati B., Eskandari K., Eskandarieh S., Fadhil I., Faraon E.J.A., Fareed M., Faris P.S., Farwati M., Farzadfar F., Fasanmi A.O., Fattahi N., Fauk N.K., Feigin V.L., Feleke B.E., Fereshtehnejad S.-M., Fernandes E., Ferrara P., Foigt N.A., Fomenkov A.A., Foroutan M., Francis J.M., Franklin R.C., Freitas M., Fukumoto T., Gad M.M., Gaidhane A.M., Gayesa R.T., Geberemariyam B.S., Gebregiorgis B.G., Gebremariam H., Gebremariam T.B.B., Gebremeskel L., Gebremeskel G.G., Gebreslassie A.A., Geramo Y.C.D., Gesesew H.A., Gessner B.D., Getacher L., Ghadiri K., Ghaffarifar F., Ghafourifard M., Ghajarzadeh M., Ghamari F., Ghashghaee A., Ghith N., Gilani S.A., Gill T.K., Godinho M.A., Gona P.N., Grada A., Gubari M.I.M., Gudi N., Guido D., Guled R.A., Guo Y., Gupta R., Haj-Mirzaian A., Hamadeh R.R., Handiso D.W., Hanif A., Hargono A., Hasaballah A.I., Hasan M.M., Hasan S.S., Hashemian M., Hashi A., Hassan S., Hassan A., Hassanipour S., Hassankhani H., Hayat K., Hegazy M.I., Heidari-Soureshjani R., Henry N.J., Herteliu C., Heydarpour F., Heydarpour S., Hidru H.D., Hoang C.L., Holla R., Hon J., Hong S.H., Hoogar P., Hosseini S.N., Hosseinzadeh M., Hostiuc M., Hostiuc S., Hotez P.J., Househ M., Huda T.M., Huluko D.H.H., Hussain S.A., Hwang B.-F., Ilesanmi O.S., Ilic I.M., Ilic M.D., Inbaraj L.R., Iqbal U., Islam M.M., Islam S.M.S., Iwu C.J., Iwu C.C.D., Jadidi-Niaragh F., Jahani M.A., Jain V., Jakovljevic M., Jalali A., Jalilian F., Janodia M.D., Javaheri T., Jha R.P., John O., Johnson K.B., Jonas J.B., Jonnagaddala J., Joseph N., Joshi A., Joukar F., Jozwiak J.J., Kabir A., Kabir Z., Kahlon T., Kalankesh L.R., Kalhor R., Kamath A., Kamiab Z., Kanchan T., Kapil U., Kapoor N., Karami Matin B., Karimi S.E., Kasa A.S., Kasahun G.G., Kassa Z.Y., Kassa G.G., Kassahun G., Kayode G.A., Kazemi Karyani A., Keflie T.S., Keiyoro P.N., Kelkay B., Keramati M., Ketema D.B., Khalid N., Khammarnia M., Khan M.N., Khan M., Khan J., Khatab K., Khater A.M., Khater M.M., Khoja A.T., Khubchandani J., Kianipour N., Kim Y.-E., Kim Y.J., Kimokoti R.W., Kisa S., Kisa A., Kolola T., Koolivand A., Kosen S., Koul P.A., Koyanagi A., Krishan K., Krishnamoorthy V., Kuate Defo B., Kugbey N., Kulkarni V., Kumar G.A., Kumar N., Kumar P., Kumar M., Kurmi O.P., Kusuma D., Lacey B., Lad D.P., Lal D.K., Lami F.H., Landires I., Larsson A.O., Lasrado S., Laurens M.B., La Vecchia C., Laxmaiah A., Lee P.H., Lee S.W.H., LeGrand K.E., Lewycka S., Li B., Li S., Liu X., Lopez J.C.F., Machado D.B., Madhava Kunjathur S., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahadeshwara Prasad D.R., Mahasha P.W., Maheri M., Mahotra N.B., Majeed A., Maled V., Maleki S., Malekzadeh R., Malta D.C., Mamun A.A., Mansour-Ghanaei F., Mansouri B., Mansournia M.A., Manzar M.D.D., Marrugo Arnedo C.A., Martins-Melo F.R., Masaka A., Maulik P.K., Mayala B.K., Mehari M., Mehndiratta M.M., Mehrabi Nasab E., Mehri F., 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Abstract

Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000-2018 geospatial estimates of anemia prevalence in women of reproductive age (15-49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Additionally, we provide subnational disparity analyses to provide a comprehensive overview of anemia prevalence inequalities within these countries and predict progress toward the World Health Organization's Global Nutrition Target (WHO GNT) to reduce anemia by half by 2030. Our results demonstrate widespread moderate improvements in overall anemia prevalence but identify only three LMICs with a high probability of achieving the WHO GNT by 2030 at a national scale, and no LMIC is expected to achieve the target in all their subnational administrative units. Our maps show where large within-country disparities occur, as well as areas likely to fall short of the WHO GNT, offering precision public health tools so that adequate resource allocation and subsequent interventions can be targeted to the most vulnerable populations.Copyright © 2021, The Author(s).

Published
2022

50. Morphological, physicochemical and proximate composition of two Philippine bignay (Antidesma bunius (L.) Spreng) cultivars at different maturity stages.

Author

Crieta, Bince Russo A., Sartagoda, Kristel June D., Flandez, Lloyd Earl L., Morales, Diane B., Pascual, Alangelico O. San, Magdalita, Pablito M., and Castillo-Israel, Katherine Ann T.

Abstract

Bignay (Antidesma bunius (L.) Spreng) is an underutilised native berry grown in several Asian countries including the Philippines. Limited studies have been carried out on specific bignay cultivars and their fruit maturity stages. This study aimed to differentiate two cultivars of bignay with respect to their morphology, physicochemical properties, and proximate compositions at different maturity stages. Morphological characterisation showed that the kalabaw cultivar had a superior performance when compared to the common cultivar. Kalabaw's whole fruit weight (0.47 - 0.54 g), equatorial diameter (8.42 - 9.05 mm), thickness (7.08-7.40 mm), flesh weight (0.42 - 0.49 g), flesh thickness (1.58 - 2.20 mm) and edible portion (90.1 - 91.1%) were significantly higher when compared to corresponding common cultivar's performances; fruit weight 0.28 - 0.34 g, equatorial diameter 7.50 - 8.00 mm, thickness 6.30 - 6.95 mm, flesh weight 0.25 - 0.31 g, flesh thickness 1.33 - 1.90 mm and edible portion 88.5 - 89.5%. The superiority of kalabaw includes the measured seed parameters. For the physicochemical and proximate compositions, there is not much of a difference, while kalabaw had a lower sugar (3.40 - 8.00%) and acidity (0.36 - 0.65%) content, its moisture (13.7 - 18.3%), crude fat (4.64 - 5.66%) and crude fibre (5.37 - 10.10%) content were higher compared to the common cultivar. This study showed that kalabaw could be best used for the production of different value-added products. [ABSTRACT FROM AUTHOR]

Published
2022

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