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1. Overview of the EUROfusion Tokamak Exploitation programme in support of ITER and DEMO

Author

E. Joffrin, M. Wischmeier, M. Baruzzo, A. Hakola, A. Kappatou, D. Keeling, B. Labit, E. Tsitrone, N. Vianello, the ASDEX Upgrade Team, JET Contributors, the MAST-U Team, the TCV Team, the WEST Team, the EUROfusion Tokamak Exploitation Team:, D. Abate, J. Adamek, M. Agostini, C. Albert, F.C.P. Albert Devasagayam, S. Aleiferis, E. Alessi, J. Alhage, S. Allan, J. Allcock, M. Alonzo, G. Anastasiou, E. Andersson Sunden, C. Angioni, Y. Anquetin, L. Appel, G.M. Apruzzese, M. Ariola, C. Arnas, J.F. Artaud, W. Arter, O. Asztalos, L. Aucone, M.H. Aumeunier, F. Auriemma, J. Ayllon, E. Aymerich, A. Baciero, F. Bagnato, L. Bähner, F. Bairaktaris, P. Balázs, L. Balbinot, I. Balboa, M. Balden, A. Balestri, M. Baquero Ruiz, T. Barberis, C. Barcellona, O. Bardsley, S. Benkadda, T. Bensadon, E. Bernard, M. Bernert, H. Betar, R. Bianchetti Morales, J. Bielecki, R. Bilato, P. Bilkova, W. Bin, G. Birkenmeier, R. Bisson, P. Blanchard, A. Bleasdale, V. Bobkov, A. Boboc, A. Bock, K. Bogar, P. Bohm, T. Bolzonella, F. Bombarda, N. Bonanomi, L. Boncagni, D. Bonfiglio, R. Bonifetto, M. Bonotto, D. Borodin, I. Borodkina, T.O.S.J. Bosman, C. Bourdelle, C. Bowman, S. Brezinsek, D. Brida, F. Brochard, R. Brunet, D. Brunetti, V. Bruno, R. Buchholz, J. Buermans, H. Bufferand, P. Buratti, A. Burckhart, J. Cai, R. Calado, J. Caloud, S. Cancelli, F. Cani, B. Cannas, M. Cappelli, S. Carcangiu, A. Cardinali, S. Carli, D. Carnevale, M. Carole, M. Carpita, D. Carralero, F. Caruggi, I.S. Carvalho, I. Casiraghi, A. Casolari, F.J. Casson, C. Castaldo, A. Cathey, F. Causa, J. Cavalier, M. Cavedon, J. Cazabonne, M. Cecconello, L. Ceelen, A. Celora, J. Cerovsky, C.D. Challis, R. Chandra, A. Chankin, B. Chapman, H. Chen, M. Chernyshova, A.G. Chiariello, P. Chmielewski, A. Chomiczewska, C. Cianfarani, G. Ciraolo, J. Citrin, F. Clairet, S. Coda, R. Coelho, J.W. Coenen, I.H. Coffey, C. Colandrea, L. Colas, S. Conroy, C. Contre, N.J. Conway, L. Cordaro, Y. Corre, D. Costa, S. Costea, D. Coster, X. Courtois, C. Cowley, T. Craciunescu, G. Croci, A.M. Croitoru, K. Crombe, D.J. Cruz Zabala, G. Cseh, T. Czarski, A. Da Ros, A. Dal Molin, M. Dalla Rosa, Y. Damizia, O. D’Arcangelo, P. David, M. De Angeli, E. De la Cal, E. De La Luna, G. De Tommasi, J. Decker, R. Dejarnac, D. Del Sarto, G. Derks, C. Desgranges, P. Devynck, S. Di Genova, L.E. di Grazia, A. Di Siena, M. Dicorato, M. Diez, M. Dimitrova, T. Dittmar, L. Dittrich, J.J. Domínguez Palacios Durán, P. Donnel, D. Douai, S. Dowson, S. Doyle, M. Dreval, P. Drews, L. Dubus, R. Dumont, D. Dunai, M. Dunne, A. Durif, F. Durodie, G. Durr Legoupil Nicoud, B. Duval, R. Dux, T. Eich, A. Ekedahl, S. Elmore, G. Ericsson, J. Eriksson, B. Eriksson, F. Eriksson, S. Ertmer, A. Escarguel, B. Esposito, T. Estrada, E. Fable, M. Faitsch, N. Fakhrayi Mofrad, A. Fanni, T. Farley, M. Farník, N. Fedorczak, F. Felici, X. Feng, J. Ferreira, D. Ferreira, N. Ferron, O. Fevrier, O. Ficker, A.R. Field, A. Figueiredo, N. Fil, D. Fiorucci, M. Firdaouss, R. Fischer, M. Fitzgerald, M. Flebbe, M. Fontana, J. Fontdecaba Climent, A. Frank, E. Fransson, L. Frassinetti, D. Frigione, S. Futatani, R. Futtersack, S. Gabriellini, D. Gadariya, D. Galassi, K. Galazka, J. Galdon, S. Galeani, D. Gallart, A. Gallo, C. Galperti, M. Gambrioli, S. Garavaglia, J. Garcia, M. Garcia Munoz, J. Gardarein, L. Garzotti, J. Gaspar, R. Gatto, P. Gaudio, M. Gelfusa, J. Gerardin, S.N. Gerasimov, R. Gerru Miguelanez, G. Gervasini, Z. Ghani, F.M. Ghezzi, G. Ghillardi, L. Giannone, S. Gibson, L. Gil, A. Gillgren, E. Giovannozzi, C. Giroud, G. Giruzzi, T. Gleiter, M. Gobbin, V. Goloborodko, A. González Ganzábal, T. Goodman, V. Gopakumar, G. Gorini, T. Görler, S. Gorno, G. Granucci, D. Greenhouse, G. Grenfell, M. Griener, W. Gromelski, M. Groth, O. Grover, M. Gruca, A. Gude, C. Guillemaut, R. Guirlet, J. Gunn, T. Gyergyek, L. Hagg, J. Hall, C.J. Ham, M. Hamed, T. Happel, G. Harrer, J. Harrison, D. Harting, N.C. Hawkes, P. Heinrich, S. Henderson, P. Hennequin, R. Henriques, S. Heuraux, J. Hidalgo Salaverri, J. Hillairet, J.C. Hillesheim, A. Hjalmarsson, A. Ho, J. Hobirk, E. Hodille, M. Hölzl, M. Hoppe, J. Horacek, N. Horsten, L. Horvath, M. Houry, K. Hromasova, J. Huang, Z. Huang, A. Huber, E. Huett, P. Huynh, A. Iantchenko, M. Imrisek, P. Innocente, C. Ionita Schrittwieser, H. Isliker, P. Ivanova, I. Ivanova Stanik, M. Jablczynska, S. Jachmich, A.S. Jacobsen, P. Jacquet, A. Jansen van Vuuren, A. Jardin, H. Järleblad, A. Järvinen, F. Jaulmes, T. Jensen, I. Jepu, S. Jessica, T. Johnson, A. Juven, J. Kalis, J. Karhunen, R. Karimov, A.N. Karpushov, S. Kasilov, Y. Kazakov, P.V. Kazantzidis, W. Kernbichler, HT. Kim, D.B. King, V.G. Kiptily, A. Kirjasuo, K.K. Kirov, A. Kirschner, A. Kit, T. Kiviniemi, F. Kjær, E. Klinkby, A. Knieps, U. Knoche, M. Kochan, F. Köchl, G. Kocsis, J.T.W. Koenders, L. Kogan, Y. Kolesnichenko, Y. Kominis, M. Komm, M. Kong, B. Kool, S.B. Korsholm, D. Kos, M. Koubiti, J. Kovacic, Y. Kovtun, E. Kowalska Strzeciwilk, K. Koziol, M. Kozulia, A. Krämer Flecken, A. Kreter, K. Krieger, U. Kruezi, O. Krutkin, O. Kudlacek, U. Kumar, H. Kumpulainen, M.H. Kushoro, R. Kwiatkowski, M. La Matina, M. Lacquaniti, L. Laguardia, P. Lainer, P. Lang, M. Larsen, E. Laszynska, K.D. Lawson, A. Lazaros, E. Lazzaro, M.Y.K. Lee, S. Leerink, M. Lehnen, M. Lennholm, E. Lerche, Y. Liang, A. Lier, J. Likonen, O. Linder, B. Lipschultz, A. Listopad, X. Litaudon, E. Litherland Smith, D. Liuzza, T. Loarer, P.J. Lomas, J. Lombardo, N. Lonigro, R. Lorenzini, C. Lowry, T. Luda di Cortemiglia, A. Ludvig Osipov, T. Lunt, V. Lutsenko, E. Macusova, R. Mäenpää, P. Maget, C.F. Maggi, J. Mailloux, S. Makarov, K. Malinowski, P. Manas, A. Mancini, D. Mancini, P. Mantica, M. Mantsinen, J. Manyer, M. Maraschek, G. Marceca, G. Marcer, C. Marchetto, S. Marchioni, A. Mariani, M. Marin, M. Markl, T. Markovic, D. Marocco, S. Marsden, L. Martellucci, P. Martin, C. Martin, F. Martinelli, L. Martinelli, J.R. Martin Solis, R. Martone, M. Maslov, R. Masocco, M. Mattei, G.F. Matthews, D. Matveev, E. Matveeva, M.L. Mayoral, D. Mazon, S. Mazzi, C. Mazzotta, G. McArdle, R. McDermott, K. McKay, A.G. Meigs, C. Meineri, A. Mele, V. Menkovski, S. Menmuir, A. Merle, H. Meyer, K. Mikszuta Michalik, D. Milanesio, F. Militello, A. Milocco, I.G. Miron, J. Mitchell, R. Mitteau, V. Mitterauer, J. Mlynar, V. Moiseenko, P. Molna, F. Mombelli, C. Monti, A. Montisci, J. Morales, P. Moreau, J.M. Moret, A. Moro, D. Moulton, P. Mulholland, M. Muraglia, A. Murari, A. Muraro, P. Muscente, D. Mykytchuk, F. Nabais, Y. Nakeva, F. Napoli, E. Nardon, M.F. Nave, R.D. Nem, A. Nielsen, S.K. Nielsen, M. Nocente, R. Nouailletas, S. Nowak, H. Nyström, R. Ochoukov, N. Offeddu, S. Olasz, C. Olde, F. Oliva, D. Oliveira, H.J.C. Oliver, P. Ollus, J. Ongena, F.P. Orsitto, N. Osborne, R. Otin, P. Oyola Dominguez, D.I. Palade, S. Palomba, O. Pan, N. Panadero, E. Panontin, A. Papadopoulos, P. Papagiannis, G. Papp, V.V. Parail, C. Pardanaud, J. Parisi, A. Parrott, K. Paschalidis, M. Passoni, F. Pastore, A. Patel, B. Patel, A. Pau, G. Pautasso, R. Pavlichenko, E. Pawelec, B. Pegourie, G. Pelka, E. Peluso, A. Perek, E. Perelli Cippo, C. Perez Von Thun, P. Petersson, G. Petravich, Y. Peysson, V. Piergotti, L. Pigatto, C. Piron, L. Piron, A. Pironti, F. Pisano, U. Plank, B. Ploeckl, V. Plyusnin, A. Podolnik, Y. Poels, G. Pokol, J. Poley, G. Por, M. Poradzinski, F. Porcelli, L. Porte, C. Possieri, A. Poulsen, I. Predebon, G. Pucella, M. Pueschel, P. Puglia, O. Putignano, T. Pütterich, V. Quadri, A. Quercia, M. Rabinski, L. Radovanovic, R. Ragona, H. Raj, M. Rasinski, J. Rasmussen, G. Ratta, S. Ratynskaia, R. Rayaprolu, M. Rebai, A. Redl, D. Rees, D. Refy, M. Reich, H. Reimerdes, B.C.G. Reman, O. Renders, C. Reux, D. Ricci, M. Richou, S. Rienacker, D. Rigamonti, F. Rigollet, F.G. Rimini, D. Ripamonti, N. Rispoli, N. Rivals, J.F. Rivero Rodriguez, C. Roach, G. Rocchi, S. Rode, P. Rodrigues, J. Romazanov, C.F. Romero Madrid, J. Rosato, R. Rossi, G. Rubino, J. Rueda Rueda, J. Ruiz Ruiz, P. Ryan, D. Ryan, S. Saarelma, R. Sabot, M. Salewski, A. Salmi, L. Sanchis, A. Sand, J. Santos, K. Särkimäki, M. Sassano, O. Sauter, G. Schettini, S. Schmuck, P. Schneider, N. Schoonheere, R. Schramm, R. Schrittwieser, C. Schuster, N. Schwarz, F. Sciortino, M. Scotto D’Abusco, S. Scully, A. Selce, L. Senni, M. Senstius, G. Sergienko, S.E. Sharapov, R. Sharma, A. Shaw, U. Sheikh, G. Sias, B. Sieglin, S.A. Silburn, C. Silva, A. Silva, D. Silvagni, B. Simmendefeldt Schmidt, L. Simons, J. Simpson, L. Singh, S. Sipilä, Y. Siusko, S. Smith, A. Snicker, E.R. Solano, V. Solokha, M. Sos, C. Sozzi, F. Spineanu, G. Spizzo, M. Spolaore, L. Spolladore, C. Srinivasan, A. Stagni, Z. Stancar, G. Stankunas, J. Stober, P. Strand, C.I. Stuart, F. Subba, G.Y. Sun, H.J. Sun, W. Suttrop, J. Svoboda, T. Szepesi, G. Szepesi, B. Tal, T. Tala, P. Tamain, G. Tardini, M. Tardocchi, D. Taylor, G. Telesca, A. Tenaglia, A. Terra, D. Terranova, D. Testa, C. Theiler, E. Tholerus, B. Thomas, E. Thoren, A. Thornton, A. Thrysoe, Q. TICHIT, W. Tierens, A. Titarenko, P. Tolias, E. Tomasina, M. Tomes, E. Tonello, A. Tookey, M. Toscano Jiménez, C. Tsironis, C. Tsui, A. Tykhyy, M. Ugoletti, M. Usoltseva, D.F. Valcarcel, A. Valentini, M. Valisa, M. Vallar, M. Valovic, SI. Valvis, M. van Berkel, D. Van Eester, S. Van Mulders, M. van Rossem, R. Vann, B. Vanovac, J. Varela Rodriguez, J. Varje, S. Vartanian, M. Vecsei, L. Velarde Gallardo, M. Veranda, T. Verdier, G. Verdoolaege, K. Verhaegh, L. Vermare, G. Verona Rinati, J. Vicente, E. Viezzer, L. Vignitchouk, F. Villone, B. Vincent, P. Vincenzi, M.O. Vlad, G. Vogel, I. Voitsekhovitch, I. Voldiner, P. Vondracek, N.M.T. VU, T. Vuoriheimo, C. Wade, E. Wang, T. Wauters, M. Weiland, H. Weisen, N. Wendler, D. Weston, A. Widdowson, S. Wiesen, M. Wiesenberger, T. Wijkamp, M. Willensdorfer, T. Wilson, A. Wojenski, C. Wuethrich, I. Wyss, L. Xiang, S. Xu, D. Yadykin, Y. Yakovenko, H. Yang, V. Yanovskiy, R. Yi, B. Zaar, G. Zadvitskiy, L. Zakharov, P. Zanca, D. Zarzoso, Y. Zayachuk, J. Zebrowski, M. Zerbini, P. Zestanakis, C. F. B. Zimmermann, M. Zlobinski, A. Zohar, V.K. Zotta, X. Zou, M. Zuin, M. Zurita, and I. Zychor

Subjects
JET, ASDEX Upgrade, MAST-U, TCV, WEST, Tokamak Exploitation Task Force, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Within the 9th European Framework programme, since 2021 EUROfusion is operating five tokamaks under the auspices of a single Task Force called ‘Tokamak Exploitation’. The goal is to benefit from the complementary capabilities of each machine in a coordinated way and help in developing a scientific output scalable to future largre machines. The programme of this Task Force ensures that ASDEX Upgrade, MAST-U, TCV, WEST and JET (since 2022) work together to achieve the objectives of Missions 1 and 2 of the EUROfusion Roadmap: i) demonstrate plasma scenarios that increase the success margin of ITER and satisfy the requirements of DEMO and, ii) demonstrate an integrated approach that can handle the large power leaving ITER and DEMO plasmas. The Tokamak Exploitation task force has therefore organized experiments on these two missions with the goal to strengthen the physics and operational basis for the ITER baseline scenario and for exploiting the recent plasma exhaust enhancements in all four devices (PEX: Plasma EXhaust) for exploring the solution for handling heat and particle exhaust in ITER and develop the conceptual solutions for DEMO. The ITER Baseline scenario has been developed in a similar way in ASDEX Upgrade, TCV and JET. Key risks for ITER such as disruptions and run-aways have been also investigated in TCV, ASDEX Upgrade and JET. Experiments have explored successfully different divertor configurations (standard, super-X, snowflakes) in MAST-U and TCV and studied tungsten melting in WEST and ASDEX Upgrade. The input from the smaller devices to JET has also been proven successful to set-up novel control schemes on disruption avoidance and detachment.

Published
2024
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2. Modeling of plasma facing component erosion, impurity migration, dust transport and melting processes at JET-ILW

Author

I. Borodkina, D.V. Borodin, D. Douai, J. Romazanov, E. Pawelec, E. de la Cal, H. Kumpulainen, S. Ratynskaia, L. Vignitchouk, D. Tskhakaya, A. Kirschner, E. Lazzaro, A. Uccello, S. Brezinsek, T. Dittmar, M. Groth, A. Huber, E. Thoren, G. Gervasini, F. Ghezzi, F. Causa, A. Widdowson, K. Lawson, D. Matveev, S. Wiesen, L. Laguardia, and JET Contributors

Subjects
JET, impurity transport, physical erosion, beryllium, tungsten, isotope effect, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

An overview of the modeling approaches, validation methods and recent main results of analysis and modeling activities related to the plasma-surface interaction (PSI) in JET-ILW experiments, including the recent H/D/T campaigns, is presented in this paper. Code applications to JET experiments improve general erosion/migration/retention prediction capabilities as well as various physics extensions, for instance a treatment of dust particles transport and a detailed description of melting and splashing of PFC induced by transient events at JET. 2D plasma edge transport codes like the SOLPS-ITER code as well as PSI codes are key to realistic description of relevant physical processes in power and particle exhaust. Validation of the PSI and edge transport models across JET experiments considering various effects (isotope effects, first wall geometry, including detailed 3D shaping of plasma-facing components, self-sputtering, thermo-forces, physical and chemically assisted physical sputtering formation of W and Be hydrides) is very important for predictive simulations of W and Be erosion and migration in ITER as well as for increasing quantitative credibility of the models. JET also presents a perfect test-bed for the investigation and modeling of melt material dynamics and its splashing and droplet ejection mechanisms. We attribute the second group of processes rather to transient events as for the steady state and, thus, treat those as independent additions outside the interplay with the first group.

Published
2024
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3. POS0175 ASSOCIATIONS BETWEEN CHRONIC WIDESPREAD PAIN, PRESSURE PAIN THRESHOLDS AND LEPTIN IN INDIVIDUALS WITH KNEE PAIN

Author

M. Andersson, E. Thoren, C. Sylwander, and S. Bergman

Subjects
Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract

BackgroundPrevious studies have reported associations between obesity, chronic pain and increased pain sensitivity. The adipokine leptin has been suggested to be involved in the osteoarthritis process as well as in pain sensitisation.ObjectivesThe aim was to study associations between chronic widespread pain, pain sensitivity and leptin in individuals with knee pain.MethodsIn all, 306 individuals with knee pain were included in the Halland osteoarthritis cohort, ClinicalTrials.gov NCT04928170. Of those, 265 were included in this cross-sectional baseline study. The mean age (sd) was 51.6 (8.8) years, and 71% was women. The participants marked their painful areas on a pain figure with 18 predefined areas. They were categorised in three different pain groups according to the modified WP2019 definition (1), with knees excluded (due to highest goodness of fit): Chronic widespread pain (CWP), chronic regional pain (ChRP) if CWP was not met, and no chronic pain (NCP). The group with CWP were compared with those reporting no CWP (ChRP and NCP). The pressure pain thresholds (PPT) were measured using a computerised pressure algometry (AlgoMed, Medoc) on eight predefined tender points (trapezius (bilateral), right second rib, right lateral epicondyle, knees, gluteal (bilateral)) (2). Increased pain sensitivity was defined as having PPT in the lowest third in all tender points. Obesity was measured via waistline measurement and a bioimpedance (InBody 770) measuring BMI and visceral fat area (VFA). Serum-Leptin were analysed with an ELISA method (Alpco). Knee Injury and Osteoarthritis Outcome Score (KOOS) was used to describe the groups.ResultsIn this baseline study, 16% reported CWP, and 15% had low pain pressure thresholds at baseline in the study. Those fulfilling CWP were more often women, had higher BMI, VFA, and increased leptin levels and worse KOOS in four of five subscores, see Table 1A. The age and gender-adjusted leptin levels were 21.6 ng/ml (95% CI 18.2-25.0) in the group with no CWP vs. 35.5 ng/ml (95% CI 27.6-43.4) in the CWP group, p=0.002. In a logistic regression adjusting for age and gender, leptin was associated with reporting CWP OR 1.015 (95% CI 1.004-1.027, p= 0.008).Table 1.A Comparisons between those without CWP and those fulfilling CWP and table 1B comparisons between those not having low PPT and those with low PPT.ABNo CWPMean (sd)CWPMean (sd)p-valueNot Low PPTMean (sd)Low PPTMean (sd)p-valuen2104022639Age51.8 (8.7)52.8 (7.6)0.46552.1 (8.5)48.8 (9.9)0.030Gender, female n(%)67900.00472670.524BMI (kg/m2)26.2 (4.6)28.0 (5.0)0.02226.4 (4.9)27.5 (4.3)0.213VFA (cm2)107 (50)137 (56)0.001110 (54)127 (49)0.088Leptin (ng/ml)21.0 (23.9)39.0 (36.6)23.0 (26.0)31.8 (31.6)0.061CRP (mg/L)1.9 (2.7)2.2 (2.3)0.6022.0 (2.7)1.9 (1.8)0.825KOOSPain (0-100, worst to best)74 (15)61 (17)73 (15)65 (18)0.002Symptom (0-100, worst to best)72 (17)64 (18)0.01671 (17)67 (19)0.188ADL (0-100, worst to best)84 (13)69 (19)84 (14)72 (21)Sport/rec (0-100, worst to best)49 (26)34 (27)0.00149 (26)36 (25)0.009QoL (0-100, worst to best)53 (18)46 (20)0.05053 (18)45 (21)0.017BMI, body mass index; VFA, visceral fat area; CRP, C-reactive protein; KOOS, knee injury and osteoarthritis outcome score; ADL; function in daily living; sport/Rec, Function in sport and recreation; QOL, knee-related Quality of lifeThe participants with low PPT were younger and had a mean (sd) leptin 31.8 ng/ml (31.6) vs 23.0 (26.0), p=0.061 in the group not having low PPT, Table 1B. In a logistic regression adjusting for age and gender, leptin was associated with low PPT OR 1.016 (95% CI 1.004-1.029, p= 0.012).ConclusionThe pathophysiological mechanism causing widespread pain is probably multifactorial, involving both biological and physical factors. The adipokine leptin could be involved in some of these mechanisms, but longitudinal studies are needed to be able to study causal relationships.References[1]Wolfe F, et al. Scand J Pain. 2019;20:77-86.[2]Wolfe F, et al. Arthritis and rheumatism. 1990;33:160-72.Disclosure of InterestsNone declared

Published
2022
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4. Overview of ASDEX upgrade results in view of ITER and DEMO

Author

H. Zohm, E. Alessi, C. Angioni, N. Arden, V. Artigues, M. Astrain, O. Asunta, M. Balden, V. Bandaru, A. Banon Navarro, M. Bauer, A. Bergmann, M. Bergmann, J. Bernardo, M. Bernert, A. Biancalani, R. Bielajew, R. Bilato, G. Birkenmeier, T. Blanken, V. Bobkov, A. Bock, L. Bock, T. Body, T. Bolzonella, N. Bonanomi, A. Bortolon, B. Böswirth, C. Bottereau, A. Bottino, H. van den Brand, M. Brenzke, S. Brezinsek, D. Brida, F. Brochard, J. Buchanan, A. Buhler, A. Burckhart, Y. Camenen, B. Cannas, P. Cano Megías, D. Carlton, M. Carr, P. Carvalho, C. Castaldo, A. Castillo Castillo, A. Cathey, M. Cavedon, C. Cazzaniga, C. Challis, A. Chankin, A. Chomiczewska, C. Cianfarani, F. Clairet, S. Coda, R. Coelho, J.W. Coenen, L. Colas, G. Conway, S. Costea, D. Coster, T. Cote, A.J. Creely, G. Croci, D.J. Cruz Zabala, G. Cseh, I. Cziegler, O. D’Arcangelo, A. Dal Molin, P. David, C. Day, M. de Baar, P. de Marné, R. Delogu, P. Denner, A. Di Siena, M. Dibon, J.J. Dominguez-Palacios Durán, D. Dunai, M. Dreval, M. Dunne, B.P. Duval, R. Dux, T. Eich, S. Elgeti, A. Encheva, B. Esposito, E. Fable, M. Faitsch, D. Fajardo Jimenez, U. Fantz, M. Farnik, H. Faugel, F. Felici, O. Ficker, A. Figueredo, R. Fischer, O. Ford, L. Frassinetti, M. Fröschle, G. Fuchert, J.C. Fuchs, H. Fünfgelder, S. Futatani, K. Galazka, J. Galdon-Quiroga, D. Gallart Escolà, A. Gallo, Y. Gao, S. Garavaglia, M. Garcia Muñoz, B. Geiger, L. Giannone, S. Gibson, L. Gil, E. Giovannozzi, I. Girka, O. Girka, T. Gleiter, S. Glöggler, M. Gobbin, J.C. Gonzalez, J. Gonzalez Martin, T. Goodman, G. Gorini, T. Görler, D. Gradic, G. Granucci, A. Gräter, G. Grenfell, H. Greuner, M. Griener, M. Groth, O. Grover, A. Gude, L. Guimarais, S. Günter, D. Hachmeister, A.H. Hakola, C. Ham, T. Happel, N. den Harder, G. Harrer, J. Harrison, V. Hauer, T. Hayward-Schneider, B. Heinemann, P. Heinrich, T. Hellsten, S. Henderson, P. Hennequin, M. Herschel, S. Heuraux, A. Herrmann, E. Heyn, F. Hitzler, J. Hobirk, K. Höfler, S. Hörmann, J.H. Holm, M. Hölzl, C. Hopf, L. Horvath, T. Höschen, A. Houben, A. Hubbard, A. Huber, K. Hunger, V. Igochine, M. Iliasova, J. Illerhaus, K. Insulander Björk, C. Ionita-Schrittwieser, I. Ivanova-Stanik, S. Jachmich, W. Jacob, N. Jaksic, A. Jansen van Vuuren, F. Jaulmes, F. Jenko, T. Jensen, E. Joffrin, A. Kallenbach, J. Kalis, A. Kappatou, J. Karhunen, C.-P. Käsemann, S. Kasilov, Y. Kazakov, A. Kendl, W. Kernbichler, E. Khilkevitch, M. Kircher, A. Kirk, S. Kjer Hansen, V. Klevarova, F. Klossek, G. Kocsis, M. Koleva, M. Komm, M. Kong, A. Krämer-Flecken, M. Krause, I. Krebs, A. Kreuzeder, K. Krieger, O. Kudlacek, D. Kulla, T. Kurki-Suonio, B. Kurzan, B. Labit, K. Lackner, F. Laggner, A. Lahtinen, P. Lainer, P.T. Lang, P. Lauber, M. Lehnen, L. Leppin, E. Lerche, N. Leuthold, L. Li, J. Likonen, O. Linder, H. Lindl, B. Lipschultz, Y. Liu, Z. Lu, T. Luda Di Cortemiglia, N.C. Luhmann, T. Lunt, A. Lyssoivan, T. Maceina, J. Madsen, A. Magnanimo, H. Maier, J. Mailloux, R. Maingi, O. Maj, E. Maljaars, V. Maquet, A. Mancini, A. Manhard, P. Mantica, M. Mantsinen, P. Manz, M. Maraschek, C. Marchetto, M. Markl, L. Marrelli, P. Martin, F. Matos, M. Mayer, P.J. McCarthy, R. McDermott, G. Meng, R. Merkel, A. Merle, H. Meyer, M. Michelini, D. Milanesio, V. Mitterauer, P. Molina Cabrera, M. Muraca, F. Nabais, V. Naulin, R. Nazikian, R.D. Nem, R. Neu, A.H. Nielsen, S.K. Nielsen, T. Nishizawa, M. Nocente, I. Novikau, S. Nowak, R. Ochoukov, J. Olsen, P. Oyola, O. Pan, G. Papp, A. Pau, G. Pautasso, C. Paz-Soldan, M. Peglau, E. Peluso, P. Petersson, C. Piron, U. Plank, B. Plaum, B. Plöckl, V. Plyusnin, G. Pokol, E. Poli, A. Popa, L. Porte, J. Puchmayr, T. Pütterich, L. Radovanovic, M. Ramisch, J. Rasmussen, G. Ratta, S. Ratynskaia, G. Raupp, A. Redl, D. Réfy, M. Reich, F. Reimold, D. Reiser, M. Reisner, D. Reiter, B. Rettino, T. Ribeiro, D. Ricci, R. Riedl, J. Riesch, J.F. Rivero Rodriguez, G. Rocchi, P. Rodriguez-Fernandez, V. Rohde, G. Ronchi, M. Rott, M. Rubel, D.A. Ryan, F. Ryter, S. Saarelma, M. Salewski, A. Salmi, O. Samoylov, L. Sanchis Sanchez, J. Santos, O. Sauter, G. Schall, A. Schlüter, J. Scholte, K. Schmid, O. Schmitz, P.A. Schneider, R. Schrittwieser, M. Schubert, C. Schuster, N. Schwarz, T. Schwarz-Selinger, J. Schweinzer, F. Sciortino, O. Seibold-Benjak, A. Shabbir, A. Shalpegin, S. Sharapov, U. Sheikh, A. Shevelev, G. Sias, M. Siccinio, B. Sieglin, A. Sigalov, A. Silva, C. Silva, D. Silvagni, J. Simpson, S. Sipilä, A. Snicker, E. Solano, C. Sommariva, C. Sozzi, M. Spacek, G. Spizzo, M. Spolaore, A. Stegmeir, M. Stejner, D. Stieglitz, J. Stober, U. Stroth, E. Strumberger, G. Suarez Lopez, W. Suttrop, T. Szepesi, B. Tál, T. Tala, W. Tang, G. Tardini, M. Tardocchi, D. Terranova, M. Teschke, E. Thorén, W. Tierens, D. Told, W. Treutterer, G. Trevisan, M. Tripský, P. Ulbl, G. Urbanczyk, M. Usoltseva, M. Valisa, M. Valovic, S. van Mulders, M. van Zeeland, F. Vannini, B. Vanovac, P. Varela, S. Varoutis, T. Verdier, G. Verdoolaege, N. Vianello, J. Vicente, T. Vierle, E. Viezzer, I. Voitsekhovitch, U. von Toussaint, D. Wagner, X. Wang, M. Weiland, D. Wendler, A.E. White, M. Willensdorfer, B. Wiringer, M. Wischmeier, R. Wolf, E. Wolfrum, Q. Yang, C. Yoo, Q. Yu, R. Zagórski, I. Zammuto, T. Zehetbauer, W. Zhang, W. Zholobenko, A. Zibrov, M. Zilker, C.F.B. Zimmermann, A. Zito, S. Zoletnik, the EUROfusion Tokamak Exploitation Team, and the ASDEX Upgrade Team

Subjects
tokamak, MHD stability, transport modelling, radiative exhaust, disruption physics, ELM free scenarios, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Experiments on ASDEX Upgrade (AUG) in 2021 and 2022 have addressed a number of critical issues for ITER and EU DEMO. A major objective of the AUG programme is to shed light on the underlying physics of confinement, stability, and plasma exhaust in order to allow reliable extrapolation of results obtained on present day machines to these reactor-grade devices. Concerning pedestal physics, the mitigation of edge localised modes (ELMs) using resonant magnetic perturbations (RMPs) was found to be consistent with a reduction of the linear peeling-ballooning stability threshold due to the helical deformation of the plasma. Conversely, ELM suppression by RMPs is ascribed to an increased pedestal transport that keeps the plasma away from this boundary. Candidates for this increased transport are locally enhanced turbulence and a locked magnetic island in the pedestal. The enhanced D-alpha (EDA) and quasi-continuous exhaust (QCE) regimes have been established as promising ELM-free scenarios. Here, the pressure gradient at the foot of the H-mode pedestal is reduced by a quasi-coherent mode, consistent with violation of the high-n ballooning mode stability limit there. This is suggestive that the EDA and QCE regimes have a common underlying physics origin. In the area of transport physics, full radius models for both L- and H-modes have been developed. These models predict energy confinement in AUG better than the commonly used global scaling laws, representing a large step towards the goal of predictive capability. A new momentum transport analysis framework has been developed that provides access to the intrinsic torque in the plasma core. In the field of exhaust, the X-Point Radiator (XPR), a cold and dense plasma region on closed flux surfaces close to the X-point, was described by an analytical model that provides an understanding of its formation as well as its stability, i.e., the conditions under which it transitions into a deleterious MARFE with the potential to result in a disruptive termination. With the XPR close to the divertor target, a new detached divertor concept, the compact radiative divertor, was developed. Here, the exhaust power is radiated before reaching the target, allowing close proximity of the X-point to the target. No limitations by the shallow field line angle due to the large flux expansion were observed, and sufficient compression of neutral density was demonstrated. With respect to the pumping of non-recycling impurities, the divertor enrichment was found to mainly depend on the ionisation energy of the impurity under consideration. In the area of MHD physics, analysis of the hot plasma core motion in sawtooth crashes showed good agreement with nonlinear 2-fluid simulations. This indicates that the fast reconnection observed in these events is adequately described including the pressure gradient and the electron inertia in the parallel Ohm’s law. Concerning disruption physics, a shattered pellet injection system was installed in collaboration with the ITER International Organisation. Thanks to the ability to vary the shard size distribution independently of the injection velocity, as well as its impurity admixture, it was possible to tailor the current quench rate, which is an important requirement for future large devices such as ITER. Progress was also made modelling the force reduction of VDEs induced by massive gas injection on AUG. The H-mode density limit was characterised in terms of safe operational space with a newly developed active feedback control method that allowed the stability boundary to be probed several times within a single discharge without inducing a disruptive termination. Regarding integrated operation scenarios, the role of density peaking in the confinement of the ITER baseline scenario (high plasma current) was clarified. The usual energy confinement scaling ITER98( p,y ) does not capture this effect, but the more recent H20 scaling does, highlighting again the importance of developing adequate physics based models. Advanced tokamak scenarios, aiming at large non-inductive current fraction due to non-standard profiles of the safety factor in combination with high normalised plasma pressure were studied with a focus on their access conditions. A method to guide the approach of the targeted safety factor profiles was developed, and the conditions for achieving good confinement were clarified. Based on this, two types of advanced scenarios (‘hybrid’ and ‘elevated’ q -profile) were established on AUG and characterised concerning their plasma performance.

Published
2024
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5. Role of aquaporin-4 polarization in extracellular solute clearance

Author

Laura Bojarskaite, Sahar Nafari, Anne Katrine Ravnanger, Mina Martine Frey, Nadia Skauli, Knut Sindre Åbjørsbråten, Lena Catherine Roth, Mahmood Amiry-Moghaddam, Erlend A. Nagelhus, Ole Petter Ottersen, Inger Lise Bogen, Anna E. Thoren, and Rune Enger

Subjects
AQP4, Glymphatic, Waste clearance, Astrocyte, Glia, Syntrophin, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Waste from the brain has been shown to be cleared via the perivascular spaces through the so-called glymphatic system. According to this model the cerebrospinal fluid (CSF) enters the brain in perivascular spaces of arteries, crosses the astrocyte endfoot layer, flows through the parenchyma collecting waste that is subsequently drained along veins. Glymphatic clearance is dependent on astrocytic aquaporin-4 (AQP4) water channels that are highly enriched in the endfeet. Even though the polarized expression of AQP4 in endfeet is thought to be of crucial importance for glymphatic CSF influx, its role in extracellular solute clearance has only been evaluated using non-quantitative fluorescence measurements. Here we have quantitatively evaluated clearance of intrastriatally infused small and large radioactively labeled solutes in mice lacking AQP4 (Aqp4 –/– ) or lacking the endfoot pool of AQP4 (Snta1 –/– ). We confirm that Aqp4 –/– mice show reduced clearance of both small and large extracellular solutes. Moreover, we find that the Snta1 –/– mice have reduced clearance only for the 500 kDa [3H]dextran, but not 0.18 kDa [3H]mannitol suggesting that polarization of AQP4 to the endfeet is primarily important for clearance of large, but not small molecules. Lastly, we observed that clearance of 500 kDa [3H]dextran increased with age in adult mice. Based on our quantitative measurements, we confirm that presence of AQP4 is important for clearance of extracellular solutes, while the perivascular AQP4 localization seems to have a greater impact on clearance of large versus small molecules.

Published
2024
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