34 results on '"Downs, Jennifer A"'
Search Results
2. Partnerships with religious leaders to promote family planning in rural Tanzania: an open-label, cluster randomised trial
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Mwakisole, Agrey H, Lambert, Valencia J, Nzali, Aneth, Aristide, Christine, Laizer, Evarist, Cordeiro, Alexandra A, Gregory, Lupilya, Mwakisole, Nelusigwe, Nicol, Cecilia E W, Paul, Ndalloh, Kalluvya, Samuel E, Kihunrwa, Albert, Downs, David J, Wamoyi, Joyce, Downs, Jennifer A, and Lee, Myung Hee
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- 2023
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3. Effects of Schistosoma mansoni and praziquantel treatment on the lower gastrointestinal mucosa: A cohort study in Tanzania
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Pham, Khanh, Mtalitinya, Gideon S., Aristide, Christine, Airewele, Efeose A., Nyakaru, Deborah K., McMahon, Paige, Mulaki, Gerald Mulaki, Corstjens, Paul L.A.M., J.de Dood, Claudia, van Dam, Govert J., Changalucha, John M., Mazigo, Humphrey D., Lee, Myung Hee, Jaka, Hyasinta, and Downs, Jennifer A.
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- 2023
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4. Perioperative Care: Sarcoma and Melanoma
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Downs, Jennifer S., primary and Gyorki, David E., additional
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- 2023
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5. Contributors
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Abdi, Salahadin, primary, Afonso, Anoushka M., additional, Aloia, Thomas A., additional, Baldini, Gabriele, additional, Banchs, Jose, additional, Baptista-Hon, Daniel T., additional, Basen-Engquist, Karen, additional, Bello, Rosalind S., additional, Ben-Eliyahu, Shamgar, additional, Bergdahl, Celena Scheede, additional, Bhatnagar, Sushma, additional, Botdorf, Joshua, additional, Botha, Christelle, additional, Brown, David L., additional, Buggy, Donal J., additional, Burbury, Kate L., additional, Butler, Joseph, additional, Cahill, Ronan, additional, Carli, Franco, additional, Carton, Meghan, additional, Cata, Juan P., additional, Connolly, Cara, additional, Corrales, German, additional, Cortes, Jose, additional, Craven, Kimberly D., additional, Crommett, John Wilson, additional, Crosby, Kristin P., additional, Guzman, Luis Felipe Cuellar, additional, Dabo-Trubelja, Anahita, additional, Dang, Anh Quynh, additional, De Camilli, Alessandro R., additional, Desai, Madhavi D., additional, Dhesi, Jugdeep, additional, Doctor, Jeson R., additional, Downs, Jennifer S., additional, Dubowitz, Julia A., additional, Echeverry, German, additional, Enlund, Mats, additional, Ewing, Linette, additional, Finnerty, Dylan, additional, Domgue, Joël Fokom, additional, Frenzel, John, additional, Gallagher, Colleen M., additional, García-Ortega, Dorian Yarih, additional, Gerstman, Michelle, additional, Ghoshal, Arunangshu, additional, Gottumukkala, Vijaya N.R., additional, Grocott, Michael P.W., additional, Guerra-Londono, Carlos E., additional, Gupta, Sushan, additional, Gyorki, David E., additional, Hales, Tim G., additional, Hawk, Ernest, additional, Heriot, Alexander G., additional, Herman, Joseph M., additional, Hiller, Jonathan G., additional, Hubbard, Ruth E., additional, Ismail, Hilmy, additional, Itzep, Nelda, additional, Jasper, Emily, additional, Javed, Saba, additional, Jha, Bhawna, additional, Jhanji, Shaman, additional, Jones, Daryl, additional, Kapoor, Ravish, additional, Khan, Faraz, additional, Killinger, James S., additional, Koschel, Samantha, additional, Kotin, Alan, additional, Kulkarni, Atul Prabhakar, additional, La Caze, Adam, additional, Lawrentschuk, Nathan, additional, Leddy, Lauren Adrienne, additional, Ledet, Celia R., additional, Levett, Denny Z.H., additional, Leung, Debra, additional, Lin, Hui-Shan, additional, Lewis, Alexandra L., additional, Ma, Daqing, additional, Madden, Kevin, additional, Maitra, Anirban, additional, Maresso, Karen Colbert, additional, Mascarenhas, Jennifer, additional, McQueen, K. A. Kelly, additional, Mejia, Rodrigo, additional, Miles, Lachlan F., additional, Mohiuddin, Sana, additional, Molena, Daniela, additional, Moo, Tracy-Ann, additional, Moody, Karen, additional, Murphy, Declan G., additional, Myatra, Sheila Nainan, additional, Nates, Joseph L., additional, Nelson, Jonas A., additional, Eochagáin, Aisling Ní, additional, O’Connor, Ellen, additional, Okhuysen-Cawley, Regina, additional, Owusu-Agyemang, Pascal, additional, Pantvaidya, Gouri H., additional, Papadopoulos, Pamela C., additional, Parat, Marie-Odile, additional, Partridge, Judith, additional, Patel, Sephalie, additional, Patel, Vikram B., additional, Perry, Nicholas, additional, Polanco, Thais O., additional, Popovich, Shannon M., additional, Poulogiannis, George, additional, Rafael, Perez-Gonzalez Oscar, additional, Rampes, Sanketh, additional, Rao, Krithika S., additional, Raty, Sally Radelat, additional, Razvi, Shehla, additional, Reid, Natasha, additional, Ricon-Becker, Itay, additional, Riedel, Bernhard J., additional, Roarty, Emily B., additional, Rodriguez, Maria Alma, additional, Russo, Suzanne, additional, Saeed, Iqira, additional, Sahai, Sunil K., additional, Salins, Naveen, additional, Sathianathen, Niranjan, additional, Seth, Shveta, additional, Shaw, Paul N., additional, Sherwin, Aislinn, additional, Shete, Sanjay, additional, Shi, Qiuling, additional, Shields, Conor, additional, Tan, Jo-Lynn, additional, Tokita, Hanae K., additional, Wall, Tom, additional, Walters, Ronald S., additional, Wang, Xin Shelley, additional, Ward, Phil, additional, Waylen, Anna Louise, additional, Weinberg, Laurence, additional, Wichmann, Matthias Wilhelm, additional, Wigmore, Timothy, additional, Yusuf, Syed Wamique, additional, Zaky, Wafik, additional, and Zheng, Gang, additional
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- 2023
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6. The Female Global Scholars Program: A mixed-methods evaluation of a novel intervention to promote the retention and advancement of women in global health research
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Cordeiro, Alexandra A., primary, Walsh, Kathleen F., additional, Sundararajan, Radhika, additional, Reif, Lindsey K., additional, McNairy, Margaret, additional, Mathad, Jyoti, additional, Downs, Jennifer A., additional, and Fahme, Sasha A., additional
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- 2024
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7. International Center-Level Variation in Utilization of Completion Lymph Node Dissection and Adjuvant Systemic Therapy for Sentinel Lymph Node-Positive Melanoma at Major Referral Centers
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Broman, Kristy K., Hughes, Tasha M., Bredbeck, Brooke C., Sun, James, Kirichenko, Dennis, Carr, Michael J., Sharma, Avinash, Bartlett, Edmund K., Nijhuis, Amanda A.G., Thompson, John F., Hieken, Tina J., Kottschade, Lisa, Downs, Jennifer, Gyorki, David E., Stahlie, Emma, van Akkooi, Alexander, Ollila, David W., O’shea, Kristin, Song, Yun, Karakousis, Giorgos, Moncrieff, Marc, Nobes, Jenny, Vetto, John, Han, Dale, Hotz, Meghan, Farma, Jeffrey M., Deneve, Jeremiah L., Fleming, Martin D., Perez, Matthew, Baecher, Kirsten, Lowe, Michael, Bagge, Roger Olofsson, Mattsson, Jan, Lee, Ann Y., Berman, Russell S., Chai, Harvey, Kroon, Hidde M., Teras, Juri, Teras, Roland M., Farrow, Norma E., Beasley, Georgia M., Hui, Jane Yuet Ching, Been, Lukas, Kruijff, Schelto, Sinco, Brandy, Sarnaik, Amod A., Sondak, Vernon K., Zager, Jonathan S., and Dossett, Lesly A.
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- 2023
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8. Effects of Schistosoma haematobium infection and treatment on the systemic and mucosal immune phenotype, gene expression and microbiome: A systematic review.
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Mertelsmann, Anna M., Bowers, Sheridan F., Wright, Drew, Maganga, Jane K., Mazigo, Humphrey D., Ndhlovu, Lishomwa C., Changalucha, John M., and Downs, Jennifer A.
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REGULATORY B cells ,REGULATORY T cells ,CELL transformation ,SCHISTOSOMA haematobium ,P53 antioncogene - Abstract
Background: Urogenital schistosomiasis caused by Schistosoma haematobium affects approximately 110 million people globally, with the majority of cases in low- and middle-income countries. Schistosome infections have been shown to impact the host immune system, gene expression, and microbiome composition. Studies have demonstrated variations in pathology between schistosome subspecies. In the case of S. haematobium, infection has been associated with HIV acquisition and bladder cancer. However, the underlying pathophysiology has been understudied compared to other schistosome species. This systematic review comprehensively investigates and assimilates the effects of S. haematobium infection on systemic and local host mucosal immunity, cellular gene expression and microbiome. Methods: We conducted a systematic review assessing the reported effects of S. haematobium infections and anthelmintic treatment on the immune system, gene expression and microbiome in humans and animal models. This review followed PRISMA guidelines and was registered prospectively in PROSPERO (CRD42022372607). Randomized clinical trials, cohort, cross-sectional, case-control, experimental ex vivo, and animal studies were included. Two reviewers performed screening independently. Results: We screened 3,177 studies and included 94. S. haematobium was reported to lead to: (i) a mixed immune response with a predominant type 2 immune phenotype, increased T and B regulatory cells, and select pro-inflammatory cytokines; (ii) distinct molecular alterations that would compromise epithelial integrity, such as increased metalloproteinase expression, and promote immunological changes and cellular transformation, specifically upregulation of genes p53 and Bcl-2; and (iii) microbiome dysbiosis in the urinary, intestinal, and genital tracts. Conclusion: S. haematobium induces distinct alterations in the host's immune system, molecular profile, and microbiome. This leads to a diverse range of inflammatory and anti-inflammatory responses and impaired integrity of the local mucosal epithelial barrier, elevating the risks of secondary infections. Further, S. haematobium promotes cellular transformation with oncogenic potential and disrupts the microbiome, further influencing the immune system and genetic makeup. Understanding the pathophysiology of these interactions can improve outcomes for the sequelae of this devastating parasitic infection. Author summary: The parasitic trematode S. haematobium affects 110 million people worldwide. Many studies have described the effects of schistosome infections on humans and animals, but data focusing solely on S. haematobium infections, which cause urogenital schistosomiasis are scarce. Our goal was to evaluate, in a systematic manner, how S. haematobium infection affects the immune system, gene expression and microbiome of the host. These effects are important because they could lead to increased risk of infections, such as HIV, and bladder cancer. We screened 3,179 studies for potential relevance and included 94 of them in this review. Our analysis showed that S. haematobium infection profoundly alters the immune system with a mixed pro-inflammatory and anti-inflammatory response, though with a predominant type 2 immune phenotype and increased regulatory cells. We further found consistent evidence that it impairs local mucosal epithelial barrier integrity, promotes cellular transformation with pro-oncogenic changes in the host, and is associated with microbial alterations in urine, stool, and genital tracts. We discuss how these findings might be interpreted, and the additional research needed, to improve our understanding of S. haematobium pathophysiology and ameliorate the potential sequelae of S. haematobium infection, such as increased viral infections and cancer. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Health providers’ perspectives on contraceptive use in rural Northwest Tanzania: A qualitative study
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Aristide, Christine, Bullington, Brooke W., Kuguru, Magdalena, Sundararajan, Radhika, Nguyen, Natalie T., Lambert, Valencia J., Mwakisole, Agrey H., Wamoyi, Joyce, and Downs, Jennifer A.
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- 2022
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10. Flow-S: A Field-Deployable Device with Minimal Hands-On Effort to Concentrate and Quantify Schistosoma Circulating Anodic Antigen (CAA) from Large Urine Volumes
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de Jong, Daniëlle, primary, Carrell, Cody, additional, Maganga, Jane K., additional, Mhango, Loyce, additional, Shigella, Peter S., additional, Gill, Maddy, additional, Shogren, Ryan, additional, Mullins, Brianna, additional, Warrick, Jay W., additional, Changalucha, John M., additional, van Dam, Govert J., additional, Pham, Khanh, additional, Downs, Jennifer A., additional, and Corstjens, Paul L. A. M., additional
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- 2024
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11. Clinical and demographic factors associated with Kaposi’s sarcoma-associated herpesvirus shedding in saliva or cervical secretions in a cohort of Tanzanian women
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Mertelsmann, Anna M, primary, Mukerebe, Crispin, additional, Miyaye, Donald, additional, Shigella, Peter, additional, Mhango, Loyce, additional, Lutonja, Peter, additional, Corstjens, Paul L A M, additional, de Dood, Claudia, additional, van Dam, Govert J, additional, Colombe, Soledad, additional, Maganga, Jane, additional, Aristide, Christine, additional, Kalluvya, Samuel E, additional, Ward, Maureen M, additional, Cordeiro, Alexandra A, additional, Lee, Myung Hee, additional, Changalucha, John M, additional, and Downs, Jennifer A, additional
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- 2024
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12. Traditional healer support to improve HIV viral suppression in rural Uganda (Omuyambi): study protocol for a cluster randomized hybrid effectiveness-implementation trial.
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Sundararajan, Radhika, Hooda, Misha, Lai, Yifan, Nansera, Denis, Audet, Carolyn, Downs, Jennifer, Lee, Myung Hee, McNairy, Margaret, Muyindike, Winnie, and Mwanga-Amumpaire, Juliet
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HIV ,HEALERS ,ORPHANS ,VIRAL load ,RESEARCH protocols ,SOCIAL support ,TREATMENT effectiveness ,RURAL women - Abstract
Background: Rural African people living with HIV face significant challenges in entering and remaining in HIV care. In rural Uganda, for example, there is a threefold higher prevalence of HIV compared to the national average and lower engagement throughout the HIV continuum of care. There is an urgent need for appropriate interventions to improve entry and retention in HIV care for rural Ugandans with HIV. Though many adults living with HIV in rural areas prioritize seeking care services from traditional healers over formal clinical services, healers have not been integrated into HIV care programs. The Omuyambi trial is investigating the effectiveness of psychosocial support delivered by traditional healers as an adjunct to standard HIV care versus standard clinic-based HIV care alone. Additionally, we are evaluating the implementation process and outcomes, following the Consolidated Framework for Implementation Research. Methods: This cluster randomized hybrid type 1 effectiveness-implementation trial will be conducted among 44 traditional healers in two districts of southwestern Uganda. Healers were randomized 1:1 into study arms, where healers in the intervention arm will provide 12 months of psychosocial support to adults with unsuppressed HIV viral loads receiving care at their practices. A total of 650 adults with unsuppressed HIV viral loads will be recruited from healer clusters in the Mbarara and Rwampara districts. The primary study outcome is HIV viral load measured at 12 months after enrollment, which will be analyzed by intention-to-treat. Secondary clinical outcome measures include (re)initiation of HIV care, antiretroviral therapy adherence, and retention in care. The implementation outcomes of adoption, fidelity, appropriateness, and acceptability will be evaluated through key informant interviews and structured surveys at baseline, 3, 9, 12, and 24 months. Sustainability will be measured through HIV viral load measurements at 24 months following enrollment. Discussion: The Omuyambi trial is evaluating an approach that could improve HIV outcomes by incorporating previously overlooked community lay supporters into the HIV cascade of care. These findings could provide effectiveness and implementation evidence to guide the development of policies and programs aimed at improving HIV outcomes in rural Uganda and other countries where healers play an essential role in community health. Trial registration: ClinicalTrials.gov NCT05943548. Registered on July 5, 2023. The current protocol version is 4.0 (September 29, 2023). [ABSTRACT FROM AUTHOR]
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- 2024
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13. "If I chose to listen to people, I possibly wouldn't be using family planning": Impact of external influences on women's contraceptive autonomy in rural Northwest Tanzania.
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Lambert, Valencia J, Samson, Anna, Nzali, Aneth, Mukasa, Lydia, Kachembeho, Neema, Bowers, Sheridan, Kalluvya, Samuel E, Mwakisole, Agrey H, and Downs, Jennifer A
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FAMILY planning ,WOMEN ,AUTONOMY (Psychology) ,RESEARCH funding ,QUALITATIVE research ,DECISION making ,MANIPULATIVE behavior ,DESCRIPTIVE statistics ,QUANTITATIVE research ,MOTIVATION (Psychology) ,RURAL conditions ,CONTRACEPTION ,SOCIAL support ,PHENOMENOLOGY ,DATA analysis software ,SOCIODEMOGRAPHIC factors - Abstract
Background: There is an increasing emphasis on promoting women's autonomy in reproductive decision-making, particularly given global efforts to increase contraceptive access and uptake. Scales to quantify autonomy have inconsistently included the effect of external influences and focused primarily on influences of partners. Objectives: This study aimed to gain greater depth in understanding how influences including and beyond a woman's partner affect her contraceptive decision-making, as well as how external influences can overlap and further complicate contraceptive decision-making. Design: A phenomenological, qualitative study in which in-depth interviews were conducted in three phases from May 2021 to February 2022 with women living in northwest Tanzania who had varying histories of contraceptive use or non-use. Methods: One-on-one, in-depth interviews were conducted in Swahili, the national language of Tanzania, by trained female interviewers. Interviews were digitally recorded, transcribed, translated into English, and independently coded by three investigators. Analysis was conducted using NVivo. The codes developed from the transcripts were grouped into overarching themes with supporting illustrative quotes. Results: A total of 72 women were interviewed. Partners were the most influential in women's family planning decision-making, followed by friends, relatives, community religious leaders, and healthcare providers. Out of the 52 women with a partner who had ever used family planning, 76.9% had discussed their desire to use family planning with their partner and nearly all reported strong pressures to use or not to use family planning from partners, family, and friends. Rarely, participants stated that they were devoid of any influence. Conclusion: In rural Tanzania, women's decision-making about family planning was highly impacted by external influences, including not only partners but also family, friends, and community. Indicators of women's reproductive autonomy and measurements of interventions to promote contraceptive use should incorporate measures of these external influences. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Female genital schistosomiasis is a neglected public health problem in Tanzania: Evidence from a scoping review.
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Mbwanji, Gladys, Mazigo, Humphrey D., Maganga, Jane K., and Downs, Jennifer A.
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SCHISTOSOMIASIS ,SEXUALLY transmitted diseases ,MEDICAL personnel ,MEDICAL care ,SCHISTOSOMA haematobium ,GENITALIA infections - Abstract
Schistosoma haematobium, the parasite that causes urogenital schistosomiasis, is widely prevalent in Tanzania. In addition to well-known effects on the urinary tract, S. haematobium also causes clinically- evident damage to the reproductive tract in approximately half of infected women, which is known as female genital schistosomiasis (FGS). FGS has major gynecologic and social consequences on women's reproductive health, yet little information is available regarding FGS in Tanzania. To cover that gap, we conducted the present scoping review to examine the epidemiology of FGS in Tanzania (both in the mainland and Zanzibar island) and to make recommendations for future work in this area. The available evidence from community-based and hospital-based retrospective studies indicates that FGS is a significant health problem in the country. Very few community-based studies have been reported from mainland Tanzania, and Zanzibar. Our review highlights the scarcity of efforts to address FGS in Tanzania and the need for additional community-based studies. The studies will help us understand the true burden of the disease nationwide, to assess the impact of praziquantel on FGS lesions, and to address social and mental health in relation to FGS. This review emphasizes integration of delivery of FGS related services in primary health care systems through the reproductive health clinics which covers sexually transmitted infections, HIV and cervical cancer screening. These actions are essential if this neglected gynecological disease is to be addressed in Tanzania. Author summary: Female genital schistosomiasis (FGS) caused by Schistosoma haematobium affects mostly the reproductive tract of girls and women in rural and marginalized communities. This disease has been largely neglected by the schistosomiasis endemic communities and public health professionals. The present review aimed at assessing the evidence/epidemiology of FGS among women/girls in Tanzania. Furthermore, the review assessed the availability of information, published literature on FGS including comorbidities that address FGS in Tanzania mainland and Zanzibar islands. The evidence generated was important to inform the need to address FGS key gaps among researchers, healthcare workers and communities. Overall, the findings indicated that the knowledge of FGS was lacking among the endemic communities and healthcare workers. Findings from this review have shown the available gaps in literature on FGS in Tanzania, from very few community-and-hospitals based studies reported from mainland Tanzania, and Zanzibar. To address this gap, further research is essential to understanding the true burden of disease-associated morbidity, to assessing the impact of single dose praziquantel in FGS lesions, to understanding mental health in relation to FGS, and to integrating delivery of FGS related services in primary health care systems. [ABSTRACT FROM AUTHOR]
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- 2024
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15. 5.69 Impact of the COVID-19 Pandemic on Mental Health Quality and Safety Practices in Pediatric Inpatient Psychiatric Settings: A Retrospective Analysis
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Backman, Ainsley E., primary, Downs, Jennifer, additional, and Joychan, Sheena, additional
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- 2023
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16. Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review
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Pham, Khanh, primary, Mertelsmann, Anna, additional, Mages, Keith, additional, Kingery, Justin R., additional, Mazigo, Humphrey D., additional, Jaka, Hyasinta, additional, Kalokola, Fredrick, additional, Changalucha, John M., additional, Kapiga, Saidi, additional, Peck, Robert N., additional, and Downs, Jennifer A., additional
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- 2023
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17. Association of schistosome infection with adiposity in Tanzania
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Pham, Khanh, PrayGod, George, Faurholt-Jepsen, Daniel, Olsen, Mette Frahm, Kavishe, Bazil, Kitilya, Brenda, Corstjens, Paul L A M, de Dood, Claudia J, Friis, Henrik, Filteau, Suzanne, Downs, Jennifer A, Peck, Robert N, Pham, Khanh, PrayGod, George, Faurholt-Jepsen, Daniel, Olsen, Mette Frahm, Kavishe, Bazil, Kitilya, Brenda, Corstjens, Paul L A M, de Dood, Claudia J, Friis, Henrik, Filteau, Suzanne, Downs, Jennifer A, and Peck, Robert N
- Abstract
Background: Observational studies in humans have reported a link between schistosome infection and lower adiposity, but this may be explained by socioeconomic and demographic factors, intensity of infection, or common co-infections such as HIV.Methods: This was a cross-sectional study that investigated the relationship between schistosome infection and adiposity in a large, well-described cohort of Tanzanian adults living with and without HIV. Cross-sectional data were collected among adults living in Mwanza, Tanzania who were enrolled in the Chronic Infections, Co-morbidities and Diabetes in Africa (CICADA) cohort study. Schistosome circulating anodic antigen, secreted by both Schistosoma mansoni and haematobium which are endemic to Tanzania, was quantified from stored samples. Schistosome infection diagnosed by serum circulating anodic antigen levels. The primary outcome was fat mass measured by bioimpedance analysis. Secondary outcomes included fat-free mass, waist circumference, mid-upper arm circumference, and body mass index.Results: The study enrolled 1,947 adults, of whom 1,923 (98.8%) had serum available for schistosome testing. Of these, 873 (45.4%) had a serum circulating anodic antigen ≥30 pg/mL, indicating schistosome infection. Compared to uninfected individuals, those with schistosome infections had -1.1 kg [95% CI -1.9 to -0.3] lower fat mass after adjusting for age, sex, physical activity, tobacco use, education level, and socioeconomic status. Infected participants also had lower waist circumference, mid-upper arm circumference, and body mass index. Fat-free mass was not different between the two groups. Neither being HIV-infected, nor receiving antiretroviral therapy, modified associations between schistosome infection and adiposity. These associations were also not affected by Schistosoma worm burden.Conclusions: Schistosome infection was associated with lower fat mass and less cen
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- 2023
18. “Mobilizing our leaders”: A multi-country qualitative study to increase the representation of women in global health leadership
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Riche, Claudia T., primary, Reif, Lindsey K., additional, Nguyen, Natalie T., additional, Alakiu, G. Rinu, additional, Seo, Grace, additional, Mathad, Jyoti S., additional, McNairy, Margaret L., additional, Cordeiro, Alexandra A., additional, Kinikar, Aarti, additional, Walsh, Kathleen F., additional, Deschamps, Marie Marcelle, additional, Nerette, Sandy, additional, Nimkar, Smita, additional, Kayange, Neema, additional, Jaka, Hyasinta, additional, Mwaisungu, Halima M., additional, Morona, Domenica, additional, Peter, Thandiwe Yvonne, additional, Suryavanshi, Nishi, additional, Fitzgerald, Daniel W., additional, Downs, Jennifer A., additional, and Hokororo, Adolfine, additional
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- 2023
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19. Perspectives of Muslim Religious Leaders to Shape an Educational Intervention About Family Planning in Rural Tanzania: A Qualitative Study
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Chalem, Andrea, primary, Nzali, Aneth, additional, Cordeiro, Alexandra A., additional, Yussuph, Amina, additional, Laizer, Evarist, additional, Lupilya, Gregory, additional, Lusana, Malick, additional, Mwakisole, Nelusigwe, additional, Paul, Ndalloh, additional, Yahaya, Hidaya, additional, Abdalah, Abubakari, additional, Kalluvya, Samuel E., additional, Lambert, Valencia J., additional, Downs, David J., additional, Kihunrwa, Albert, additional, Downs, Jennifer A., additional, and Mwakisole, Agrey H., additional
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- 2023
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20. Association of schistosome infection with adiposity in Tanzania
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Pham, Khanh, primary, PrayGod, George, additional, Faurholt-Jepsen, Daniel, additional, Olsen, Mette F., additional, Kavishe, Bazil, additional, Kitilya, Brenda, additional, Corstjens, Paul L. A. M., additional, de Dood, Claudia J., additional, Friis, Henrik, additional, Filteau, Suzanne, additional, Downs, Jennifer A., additional, and Peck, Robert N., additional
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- 2023
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21. Schistosoma mansoni Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract
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Kingery, Justin R, primary, Chalem, Andrea, additional, Mukerebe, Crispin, additional, Shigella, Peter S, additional, Miyaye, Donald, additional, Magawa, Ruth G, additional, Ward, Maureen, additional, Kalluvya, Samuel E, additional, McCormick, Jason, additional, Maganga, Jane K, additional, Colombe, Soledad, additional, Aristide, Christine, additional, Corstjens, Paul L A M, additional, Lee, Myung Hee, additional, Changalucha, John M, additional, and Downs, Jennifer A, additional
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- 2022
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22. 1170. Effects of Helminths and Anthelmintic Treatment on Cardiometabolic Diseases and Risk Factors: A Systematic Review
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Pham, Khanh, primary, Mertelsmann, Anna, additional, Mages, Keith C, additional, Kingery, Justin, additional, Mazigo, Humphrey D, additional, Jaka, Hyasinta, additional, Kalokola, Fredrick M, additional, Changalucha, John, additional, Kapiga, Saidi, additional, Peck, Robert, additional, and Downs, Jennifer A, additional
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- 2022
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23. Outcomes with adjuvant anti-PD-1 therapy in patients with sentinel lymph node-positive melanoma without completion lymph node dissection
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Eroglu, Zeynep, primary, Broman, Kristy K, additional, Thompson, John F, additional, Nijhuis, Amanda, additional, Hieken, Tina J, additional, Kottschade, Lisa, additional, Farma, Jeffrey M, additional, Hotz, Meghan, additional, Deneve, Jeremiah, additional, Fleming, Martin, additional, Bartlett, Edmund K, additional, Sharma, Avinash, additional, Dossett, Lesly, additional, Hughes, Tasha, additional, Gyorki, David E, additional, Downs, Jennifer, additional, Karakousis, Giorgos, additional, Song, Yun, additional, Lee, Ann, additional, Berman, Russell S, additional, van Akkooi, Alexander, additional, Stahlie, Emma, additional, Han, Dale, additional, Vetto, John, additional, Beasley, Georgia, additional, Farrow, Norma E, additional, Hui, Jane Yuet Ching, additional, Moncrieff, Marc, additional, Nobes, Jenny, additional, Baecher, Kirsten, additional, Perez, Matthew, additional, Lowe, Michael, additional, Ollila, David W, additional, Collichio, Frances A, additional, Bagge, Roger Olofsson, additional, Mattsson, Jan, additional, Kroon, Hidde M, additional, Chai, Harvey, additional, Teras, Jyri, additional, Sun, James, additional, Carr, Michael J, additional, Tandon, Ankita, additional, Babacan, Nalan Akgul, additional, Kim, Younchul, additional, Naqvi, Mahrukh, additional, Zager, Jonathan, additional, and Khushalani, Nikhil I, additional
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- 2022
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24. 30 - Cuidados perioperatorios: sarcoma y melanoma
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Downs, Jennifer S. and Gyorki, David E.
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- 2023
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25. 30 - Perioperative Care: Sarcoma and Melanoma
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Downs, Jennifer S. and Gyorki, David E.
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- 2023
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26. Assessing the Effect of Electronic Medical Record Note Template on Firearm Access Screening in High-Risk Children
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Hogan, Alexander H., primary, Gadun, Anes, additional, Borrup, Kevin, additional, Hunter, Amy A., additional, Campbell, Brendan T., additional, Knod, J. Leslie, additional, Downs, Jennifer, additional, and Rogers, Steven C., additional
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- 2022
- Full Text
- View/download PDF
27. Experimental Schistosoma japonicum-induced pulmonary hypertension.
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Kassa, Biruk, Downs, Jennifer A1, Kassa, Biruk, Lee, Michael H, Kumar, Rahul, Mickael, Claudia, Sanders, Linda, Tuder, Rubin M, Mentink-Kane, Margaret, Graham, Brian B, Kassa, Biruk, Downs, Jennifer A1, Kassa, Biruk, Lee, Michael H, Kumar, Rahul, Mickael, Claudia, Sanders, Linda, Tuder, Rubin M, Mentink-Kane, Margaret, and Graham, Brian B
- Abstract
BackgroundSchistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species, Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-dependent S. mansoni pulmonary hypertension (PH). We sought to determine if another common species, S. japonicum, can also cause experimental PH.MethodsSchistosome eggs were obtained from infected mice, and administered by intraperitoneal sensitization followed by intravenous challenge to experimental mice, which underwent right heart catheterization and tissue analysis.ResultsS. japonicum sensitized and challenged mice developed PH, which was milder than that following S. mansoni sensitization and challenge. The degree of pulmonary vascular remodeling and Type 2 inflammation in the lungs was similarly proportionate. Cross-sensitization revealed that antigens from either species are sufficient to sensitize for intravenous challenge with either egg, and the degree of PH severity depended on primarily the species used for intravenous challenge. Compared to a relatively uniform distribution of S. mansoni eggs, S. japonicum eggs were observed in clusters in the lungs.ConclusionsS. japonicum can induce experimental PH, which is milder than that resulting from comparable S. mansoni exposure. This difference may result from the distribution of eggs in the lungs, and is independent of which species is used for sensitization. This result is consistent with the clearer association between S. mansoni infection and the development of schistosomiasis-associated PAH in humans.
- Published
- 2022
28. International Center-Level Variation in Utilization of Completion Lymph Node Dissection and Adjuvant Systemic Therapy for Sentinel Lymph Node Positive Melanoma at Major Referral Centers
- Author
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Broman, Kristy K., primary, Hughes, Tasha M., additional, Bredbeck, Brooke C., additional, Sun, James, additional, Kirichenko, Dennis, additional, Carr, Michael J., additional, Sharma, Avinash, additional, Bartlett, Edmund K., additional, Nijhuis, Amanda A. G., additional, Thompson, John F., additional, Hieken, Tina J., additional, Kottschade, Lisa, additional, Downs, Jennifer, additional, Gyorki, David E., additional, Stahlie, Emma, additional, van Akkooi, Alexander, additional, Ollila, David W., additional, O'shea, Kristin, additional, Song, Yun, additional, Karakousis, Giorgos, additional, Moncrieff, Marc, additional, Nobes, Jenny, additional, Vetto, John, additional, Han, Dale, additional, Hotz, Meghan, additional, Farma, Jeffrey M., additional, Deneve, Jeremiah L., additional, Fleming, Martin D., additional, Perez, Matthew, additional, Baecher, Kirsten, additional, Lowe, Michael, additional, Olofsson Bagge, Roger, additional, Mattsson, Jan, additional, Lee, Ann Y., additional, Berman, Russell S., additional, Chai, Harvey, additional, Kroon, Hidde M., additional, Teras, Juri, additional, Teras, Roland M., additional, Farrow, Norma E., additional, Beasley, Georgia M., additional, Hui, Jane Yuet Ching, additional, Been, Lukas, additional, Kruijff, Schelto, additional, Sinco, Brandy, additional, Sarnaik, Amod A., additional, Sondak, Vernon K., additional, Zager, Jonathan S., additional, and Dossett, Lesly A., additional
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- 2022
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29. Abstract 10610: Schistosomiasis and Cardiovascular Disease in 1,000 HIV-Infected and Uninfected Tanzanian Adults: A Prospective Cohort Study
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Kingery, Justin, primary, Bullington, Brooke, additional, Lee, Myung Hee, additional, Desdarius, Bernard, additional, Fadhil, Salama, additional, Kisigo, Godfrey, additional, Shigella, Peter, additional, Downs, Jennifer, additional, and Peck, Robert, additional
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- 2021
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30. Colaboradores
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Abdi, Salahadin, Afonso, Anoushka M., Aloia, Thomas A., Baldini, Gabriele, Banchs, Jose, Baptista-Hon, Daniel T., Basen-Engquist, Karen, Bello, Rosalind S., Ben-Eliyahu, Shamgar, Bergdahl, Celena Scheede, Bhatnagar, Sushma, Botdorf, Joshua, Botha, Christelle, Brown, David L., Buggy, Donal J., Burbury, Kate L., Butler, Joseph, Cahill, Ronan, Carli, Franco, Carton, Meghan, Cata, Juan P., Connolly, Cara, Corrales, German, Cortes, Jose, Craven, Kimberly D., Crommett, John Wilson, Crosby, Kristin P., Guzman, Luis Felipe Cuellar, Dabo-Trubelja, Anahita, Dang, Anh Quynh, De Camilli, Alessandro R., Desai, Madhavi D., Dhesi, Jugdeep, Doctor, Jeson R., Downs, Jennifer S., Dubowitz, Julia A., Echeverry, German, Enlund, Mats, Ewing, Linette, Finnerty, Dylan, Domgue, Joël Fokom, Frenzel, John, Gallagher, Colleen M., García-Ortega, Dorian Yarih, Gerstman, Michelle, Ghoshal, Arunangshu, Gottumukkala, Vijaya N.R., Grocott, Michael P.W., Guerra-Londono, Carlos E., Gupta, Sushan, Gyorki, David E., Hales, Tim G., Hawk, Ernest, Heriot, Alexander G., BChir, MB, Herman, Joseph M., Hiller, Jonathan G., Hubbard, Ruth E., Ismail, Hilmy, Itzep, Nelda, Jasper, Emily, Javed, Saba, Jha, Bhawna, Jhanji, Shaman, Jones, Daryl, Kapoor, Ravish, Khan, Faraz, Killinger, James S., Koschel, Samantha, Kotin, Alan, Kulkarni, Atul Prabhakar, La Caze, Adam, Lawrentschuk, Nathan, Leddy, Lauren Adrienne, Ledet, Celia R., Levett, Denny Z.H., Leung, Debra, Lin, Hui-Shan, Lewis, Alexandra L., Ma, Daqing, Madden, Kevin, Maitra, Anirban, Maresso, Karen Colbert, Mascarenhas, Jennifer, McQueen, K. A. Kelly, Mejia, Rodrigo, Miles, Lachlan F., Mohiuddin, Sana, Molena, Daniela, Moo, Tracy-Ann, Moody, Karen, Murphy, Declan G., Myatra, Sheila Nainan, Nates, Joseph L., Nelson, Jonas A., Eochagáin, Aisling Ní, O’Connor, Ellen, Okhuysen-Cawley, Regina, Owusu-Agyemang, Pascal, Pantvaidya, Gouri H., Papadopoulos, Pamela C., Parat, Marie-Odile, Partridge, Judith, Patel, Sephalie, Patel, Vikram B., Rafael Perez-Gonzalez, Oscar, Perry, Nicholas, Polanco, Thais O., Popovich, Shannon M., Poulogiannis, George, Rampes, Sanketh, Rao, Krithika S., Raty, Sally Radelat, Razvi, Shehla, Reid, Natasha, Ricon-Becker, Itay, Riedel, Bernhard J., Roarty, Emily B., Rodriguez, Maria Alma, Russo, Suzanne, Saeed, Iqira, Sahai, Sunil K., Salins, Naveen, Sathianathen, Niranjan, Seth, Shveta, Shaw, Paul N., Sherwin, Aislinn, Shete, Sanjay, Shi, Qiuling, Shields, Conor, Tan, Jo-Lynn, Tokita, Hanae K., Wall, Tom, Walters, Ronald S., Wang, Xin Shelley, Ward, Phil, Waylen, Anna Louise, Weinberg, Laurence, Wichmann, Matthias Wilhelm, Wigmore, Timothy, Yusuf, Syed Wamique, Zaky, Wafik, and Zheng, Gang
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- 2023
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31. Novel, Low-Cost Intervention to Promote Women's Advancement in Global Health Research.
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Walsh, Kathleen F., Fahme, Sasha, Reif, Lindsey K. DrPH, Mathad, Jyoti, Konopasek, Lyuba, and Downs, Jennifer A.
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- 2022
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32. A survey of surgical management of the sentinel node positive melanoma patient in the post‐MSLT2 era.
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Downs, Jennifer S., Subramaniam, Suren, Henderson, Michael A., Paton, Elizabeth, Spillane, Andrew J., Mathy, Jon A., and Gyorki, David E.
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- 2021
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33. Religious Leaders as Trusted Messengers in Combatting Hypertension in Rural Tanzanian Communities.
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Lambert, Valencia J, Kisigo, Godfrey A, Nzali, Aneth, Laizer, Evarist, Paul, Ndalloh, Walshe, Louise, Kalokola, Fredrick, Okello, Elialilia S, Sundararajan, Radhika, Mwakisole, Agrey H, Downs, Jennifer A, and Peck, Robert N
- Subjects
RELIGIOUS leaders ,RURAL health ,BLOOD pressure ,HYPERTENSION ,GENDER - Abstract
Background Hypertension is a growing public health emergency in rural sub-Saharan Africa. Based on the known influence of religious leaders in rural sub-Saharan Africa and our prior research, we explored perspectives of religious leaders on hypertension and potential strategies to improve hypertension control in their communities. Methods We conducted 31 in-depth interviews with Christian (n = 17) and Muslim (n = 14) religious leaders in rural Tanzania. Interviews focused on religious leaders' perceptions of hypertension and how they could play a role in promoting blood pressure reduction. We used interpretative phenomenological analysis, a qualitative research method, to understand religious leaders' perspectives on, and experiences with, hypertension. Results Three main themes emerged during analysis. First, we found that perceptions about causes, treatment, and complications of hypertension are influenced by religious beliefs. Second, religious beliefs can enable engagement with hypertension care through religious texts that support the use of biomedical care. Third, religious leaders are enthusiastic potential partners for promoting hypertension control in their communities. These themes were consistent between religion and gender of the religious leaders. Conclusions Religious leaders are eager to learn about hypertension, to share this knowledge with others and to contribute to improved health in their communities. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
34. Experimental Schistosoma japonicum-induced pulmonary hypertension
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Biruk Kassa, Michael H. Lee, Rahul Kumar, Claudia Mickael, Linda Sanders, Rubin M. Tuder, Margaret Mentink-Kane, Brian B. Graham, and Downs, Jennifer A
- Subjects
Inflammation ,Hypertension, Pulmonary ,Public Health, Environmental and Occupational Health ,Pulmonary ,Schistosoma mansoni ,Biological Sciences ,Cardiovascular ,Medical and Health Sciences ,Schistosoma japonicum ,Vector-Borne Diseases ,Mice ,Rare Diseases ,Good Health and Well Being ,Infectious Diseases ,Tropical Medicine ,Hypertension ,Animals ,Schistosomiasis ,Digestive Diseases ,Lung - Abstract
BackgroundSchistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species,Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-dependentS.mansonipulmonary hypertension (PH). We sought to determine if another common species,S.japonicum, can also cause experimental PH.MethodsSchistosome eggs were obtained from infected mice, and administered by intraperitoneal sensitization followed by intravenous challenge to experimental mice, which underwent right heart catheterization and tissue analysis.ResultsS.japonicumsensitized and challenged mice developed PH, which was milder than that followingS.mansonisensitization and challenge. The degree of pulmonary vascular remodeling and Type 2 inflammation in the lungs was similarly proportionate. Cross-sensitization revealed that antigens from either species are sufficient to sensitize for intravenous challenge with either egg, and the degree of PH severity depended on primarily the species used for intravenous challenge. Compared to a relatively uniform distribution ofS.mansonieggs,S.japonicumeggs were observed in clusters in the lungs.ConclusionsS.japonicumcan induce experimental PH, which is milder than that resulting from comparableS.mansoniexposure. This difference may result from the distribution of eggs in the lungs, and is independent of which species is used for sensitization. This result is consistent with the clearer association betweenS.mansoniinfection and the development of schistosomiasis-associated PAH in humans.
- Published
- 2021
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