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An essential role played by cardiotocography (CTG), is promptly detecting non-reassuring foetal status during delivery, as these abnormal changes are a prime reason for women to undergo a caesarean section. But all abnormal changes in cardiotocography does not lead to poor outcome in terms of liquor that was meconium stained or a low APGAR score at birth. As a result, research is the need of the hour, to understand their correlation; hence, showing the benefit of CTG in the precise detection of non-reassuring foetal status is correlated from the intraoperative findings discovered later. This review article aimed to see if there was a link between perioperative findings and foetal consequences in women who had a caesarean section due to foetal condition, which was not reassuring according to cardiotocographic findings.

Aims and Background: The most prevalent chronic joint disease, which remains as one of the few chronic disorders of ageing is Osteoarthritis (OA). One of the predominant symptoms of OA is pain, with very little effective treatment and contributes to limitations in daily functioning. Therapy of pain due to OA includes pharmaceutical agents that need to be used in lowest possible dose to avoid adverse effects. Lot of advances have taken place in understanding the pathogenesis of OA, however, relief of pain have always remained an unfulfilled need. The anti-inflammatory property of Curcumin is mediated through the inhibition of induction of COX-2, LOX, iNOS and production of cytokines and tumor necrosis factor and activation of transcription factors like NF-κB, and AP-1. Its oral bioavailability is extremely poor. Material and Methods: In the current study, Liposomal Curcumin was administered to 30 patients suffering from pain due to OA for 30 days. The therapeutic activity was assessed by reduction in the pain severity based on NPRS Score. Results: By 30 days, there was statistically significant decrease in NPRS score. The pain reduced significantly along with decrease in weakness and fatigue. Improvement in daily physical functioning was shown by the WOMAC Arthritis Index. In 10 subjects the serum levels of Interleukin-6 (IL-6) and Tumour Necrosis Factor (TNF)α were examined at baseline and at 30th day. There was 76% improvement in TNF-α levels and 62% improvement in IL-6 levels in these subjects. Conclusion: These results have shown for the first time in Indian population the efficacy of Liposomal Curcumin for OA Pain. [ABSTRACT FROM AUTHOR]

Structural significance of conformational preferences and ribose ring puckering of newly discovered hyper modified nucleotide, 5'-monophosphate 2-methylthio cyclic N6-threonylcarbamoyladenosine (p-ms2ct6A) have been investigated using quantum chemical semi-empirical RM1 and molecular dynamics simulation techniques. Automated geometry optimization of most stable structure of p-ms2ct6A has also been carried out with the help of abinitio (HF SCF, DFT) as well as semi empirical quantum chemical (RM1, AM1, PM3, and PM6) methods. Most stable structure of p-ms2ct6A is stabilized by intramolecular interactions between N(3)...HC(2'), N(1)...HC(16), O(13)...HC(15), and O(13)...HO(14). The torsion angles alpha (α) and beta (β) show the significant characteristic patterns with the involvement of intramolecular hydrogen bonding to provide stability to the p-ms2ct6A. Further, molecular dynamics simulations of p-ms2ct6A revealed the role of ribose sugar ring puckering i.e. C2'-endo and C3'-endo on the structural dynamics of ms2ct6A side chain. The modified nucleotide p-ms2ct6A periodically prefers both the C2'-endo and C3'-endo sugar with 'anti' and 'syn' conformations. This property of p-ms2ct6A could be useful to recognize the starting ANN codons. All atom explicit MD simulation of anticodon loop (ACL) of tRNALys of Bacillus subtilis containing ms2ct6A at 37th position showed the U-turn feature, base stacking ability with other adjacent bases and hydrogen bonding interactions similar to the isolated base p-ms2ct6A. The ribose sugar puckering contributes to the orientation of the side chain conformation of p-ms2ct6A. Thus, the present study could be helpful to understand the structure-function relationship of the hypermodified nucleoside, ms2ct6A in recognition of the proper codons AAA/AAG during protein biosynthesis. [ABSTRACT FROM AUTHOR]

Background and Aims: Diabetes mellitus is a major health problem in India. The development of a new drug of natural origin that assures safety with moderate but definite efficacy is the need of the time. Authors have developed formulation containing phytoactives from Pterocarpus marsupium Roxb and Andrographis paniculata Nees in specific proportion for the first time, as an anti-diabetic supplement which improves the glycemic control. We aim to study the effect of PtyroneTM in patients with treated uncontrolled T2DM and its safety and tolerability. Study Design: In an open labelled trial, 115 patients with T2DM were divided in three groups: Metformin, Metformin + Gliptins and Metformin + Sulphonylurea. PtyroneTM capsules were given to all the patients along with their OHA's, orally twice a day for 12 weeks. Laboratory investigations were studied at the baseline and at fixed intervals till the end of the study. Results: There was a statistically significant decrease (p value< 0.0001) in fasting and post prandial blood sugar along with triglycerides in all groups. There was reduction in levels of glycosylated haemoglobin also in all the groups. All other biochemical investigations were within normal limits. PtyroneTM capsules were well tolerated clinically and no serious adverse events were reported during the period of therapy. Conclusion: The authors have shown, for the first time, the therapeutic potential of PtyroneTM at a dose of 450 mg twice a day supplemented along with anti-diabetic medications. This therapeutic efficacy needs to be evaluated further in a larger sample size, with a placebo/active controlled randomized double blind multicentric trial. [ABSTRACT FROM AUTHOR]

Background: Vitamin C is a water-soluble vitamin and one of the most commonly used vitamins. With increasing vitamin C intake, the plasma steady state concentration reaches a maximal level of about 70-80 μM. However, from the available literature, it appears that a daily intake of about 200-400 mg of vitamin C ensures saturation of the blood in healthy individuals. Bioavailability can be increased by various methods, such as encapsulation, micronisation, etc. VitaLip-C is a liposomal form of vitamin C, which is shown to be clinically proven and evaluated by Transmission Electron Microscopy (TEM) for the presence of liposomes. Materials and Methods: In the present study, authors have studied the relative bioavailability of VitaLip-C with the marketed formulation of vitamin C in animals. Results and Conclusion: It has been observed that VitaLip-C has 88.76% higher relative oral bioavailability in comparison to marketed formulation claiming 500 mg of vitamin C. [ABSTRACT FROM AUTHOR]