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321 results on '"Dossus, Laure"'

2. Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel

Author

Levi, Hagai, Carmi, Shai, Rosset, Saharon, Yerushalmi, Rinat, Zick, Aviad, Yablonski-Peretz, Tamar, Consortium, The BCAC, Wang, Qin, Bolla, Manjeet K, Dennis, Joe, Michailidou, Kyriaki, Lush, Michael, Ahearn, Thomas, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Arndt, Volker, Augustinsson, Annelie, Auvinen, Päivi, Freeman, Laura Beane, Beckmann, Matthias, Behrens, Sabine, Bermisheva, Marina, Bodelon, Clara, Bogdanova, Natalia V, Bojesen, Stig E, Brenner, Hermann, Byers, Helen, Camp, Nicola, Castelao, Jose, Chang-Claude, Jenny, Chirlaque, María-Dolores, Chung, Wendy, Clarke, Christine, Collaborators, NBCS, Collee, Margriet J, Colonna, Sarah, Consortium, CTS, Couch, Fergus, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary, Devilee, Peter, Dork, Thilo, Dossus, Laure, Eccles, Diana M, Eliassen, A Heather, Eriksson, Mikael, Evans, Gareth, Fasching, Peter, Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, García-Closas, Montserrat, Garcia-Saenz, Jose Angel, Genkinger, Jeanine, Giles, Graham G, Goldberg, Mark, Guénel, Pascal, Hall, Per, Hamann, Ute, He, Wei, Hillemanns, Peter, Hollestelle, Antoinette, Hoppe, Reiner, Hopper, John, Investigators, ABCTB, Jakovchevska, Simona, Jakubowska, Anna, Jernström, Helena, John, Esther, Johnson, Nichola, Jones, Michael, Vijai, Joseph, Kaaks, Rudolf, Khusnutdinova, Elza, Kitahara, Cari, Koutros, Stella, Kristensen, Vessela, Kurian, Allison W, Lacey, James, Lambrechts, Diether, Le Marchand, Loic, Lejbkowicz, Flavio, Lindblom, Annika, Loibl, Sibylle, Lori, Adriana, Lubinski, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Mavroudis, Dimitrios, Menon, Usha, Mulligan, AnnaMarie, Murphy, Rachel, Nevelsteen, Ines, Newman, William G, and Obi, Nadia

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Breast Cancer, Prevention, Cancer, Humans, Female, Breast Neoplasms, Genome-Wide Association Study, Jews, Israel, Genetic Predisposition to Disease, Risk Factors, Multifactorial Inheritance, Transcription Factors, Genomics, Polymorphism, Genetic, BCAC Consortium, NBCS Collaborators, CTS Consortium, ABCTB Investigators, Polymorphism, Genetic, Medical and Health Sciences, Genetics & Heredity, Clinical sciences
Abstract

BackgroundPolygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC) risk assessment. To date, most BC GWASs have been performed in individuals of European (EUR) ancestry, and the generalisation of EUR-based PRS to other populations is a major challenge. In this study, we examined the performance of EUR-based BC PRS models in Ashkenazi Jewish (AJ) women.MethodsWe generated PRSs based on data on EUR women from the Breast Cancer Association Consortium (BCAC). We tested the performance of the PRSs in a cohort of 2161 AJ women from Israel (1437 cases and 724 controls) from BCAC (BCAC cohort from Israel (BCAC-IL)). In addition, we tested the performance of these EUR-based BC PRSs, as well as the established 313-SNP EUR BC PRS, in an independent cohort of 181 AJ women from Hadassah Medical Center (HMC) in Israel.ResultsIn the BCAC-IL cohort, the highest OR per 1 SD was 1.56 (±0.09). The OR for AJ women at the top 10% of the PRS distribution compared with the middle quintile was 2.10 (±0.24). In the HMC cohort, the OR per 1 SD of the EUR-based PRS that performed best in the BCAC-IL cohort was 1.58±0.27. The OR per 1 SD of the commonly used 313-SNP BC PRS was 1.64 (±0.28).ConclusionsExtant EUR GWAS data can be used for generating PRSs that identify AJ women with markedly elevated risk of BC and therefore hold promise for improving BC risk assessment in AJ women.

Published
2023

3. Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition

Author

Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Hoff, Geir, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Dossus, Laure, Johansson, Mattias, Freisling, Heinz, Matta, Komodo, Huybrechts, Inge, Chen, Sairah L. F., B. Borch, Kristin, Sandanger, Torkjel M., H. Nøst, Therese, Dahm, Christina C., Antoniussen, Christian S., Tin Tin, Sandar, Fournier, Agnès, Marques, Chloé, Artaud, Fanny, Sánchez, Maria-José, Guevara, Marcela, Santiuste, Carmen, Agudo, Antonio, Bajracharya, Rashmita, Katzke, Verena, Ricceri, Fulvio, Agnoli, Claudia, Bergmann, Manuela M., Schulze, Matthias B., Panico, Salvatore, Masala, Giovanna, Tjønneland, Anne, Olsen, Anja, Stocks, Tanja, Manjer, Jonas, Aizpurua-Atxega, Amaia, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., and Ferrari, Pietro

Published
2024
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4. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

Author

Middha, Pooja, Wang, Xiaoliang, Behrens, Sabine, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J, Auer, Paul L, Augustinsson, Annelie, Baert, Thaïs, Freeman, Laura E Beane, Becher, Heiko, Beckmann, Matthias W, Benitez, Javier, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Brooks-Wilson, Angela, Campa, Daniele, Canzian, Federico, Carracedo, Angel, Castelao, Jose E, Chanock, Stephen J, Chenevix-Trench, Georgia, Cordina-Duverger, Emilie, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Dossus, Laure, Dugué, Pierre-Antoine, Eliassen, A Heather, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine D, Fletcher, Olivia, Flyger, Henrik, Gabrielson, Marike, Gago-Dominguez, Manuela, Giles, Graham G, González-Neira, Anna, Grassmann, Felix, Grundy, Anne, Guénel, Pascal, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hankinson, Susan E, Harkness, Elaine F, Holleczek, Bernd, Hoppe, Reiner, Hopper, John L, Houlston, Richard S, Howell, Anthony, Hunter, David J, Ingvar, Christian, Isaksson, Karolin, Jernström, Helena, John, Esther M, Jones, Michael E, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M, Ko, Yon-Dschun, Koutros, Stella, Kurian, Allison W, Lacey, James V, Lambrechts, Diether, Larson, Nicole L, Larsson, Susanna, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Shuai, Linet, Martha, Lissowska, Jolanta, Martinez, Maria Elena, Maurer, Tabea, Mulligan, Anna Marie, Mulot, Claire, Murphy, Rachel A, Newman, William G, Nielsen, Sune F, Nordestgaard, Børge G, Norman, Aaron, O’Brien, Katie M, Olson, Janet E, Patel, Alpa V, Prentice, Ross, Rees-Punia, Erika, Rennert, Gad, Rhenius, Valerie, Ruddy, Kathryn J, and Sandler, Dale P

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer Genomics, Human Genome, Estrogen, Cancer, Women's Health, Genetics, Prevention, Aging, Breast Cancer, 2.1 Biological and endogenous factors, Adult, Female, Humans, Gene-Environment Interaction, Genetic Predisposition to Disease, Breast Neoplasms, Bayes Theorem, Genome-Wide Association Study, Risk Factors, Polymorphism, Single Nucleotide, Case-Control Studies, Breast cancer, Gene-environment interactions, Genetic epidemiology, European ancestry, CTS Consortium, ABCTB Investigators, kConFab Investigators, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundGenome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.MethodsAnalyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess the noteworthiness of each SNP-risk factor pairs.ResultsAssuming a 1 × 10-5 prior probability of a true association for each SNP-risk factor pairs and a Bayesian False Discovery Probability

Published
2023

5. Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

Author

Mueller, Stefanie H, Lai, Alvina G, Valkovskaya, Maria, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Lush, Michael, Abu-Ful, Zomoruda, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Baert, Thais, Freeman, Laura E Beane, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Bonanni, Bernardo, Brenner, Hermann, Brucker, Sara Y, Buys, Saundra S, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Choi, Ji-Yeob, Chung, Wendy K, Colonna, Sarah V, Cornelissen, Sten, Couch, Fergus J, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dossus, Laure, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Engel, Christoph, Evans, D Gareth, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Gago-Dominguez, Manuela, Gao, Yu-Tang, García-Closas, Montserrat, García-Sáenz, José A, Genkinger, Jeanine, Gentry-Maharaj, Aleksandra, Grassmann, Felix, Guénel, Pascal, Gündert, Melanie, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Harkness, Elaine F, Harrington, Patricia A, Hartikainen, Jaana M, Hartman, Mikael, Hein, Alexander, Ho, Weang-Kee, Hooning, Maartje J, Hoppe, Reiner, Hopper, John L, Houlston, Richard S, Howell, Anthony, Hunter, David J, Huo, Dezheng, Ito, Hidemi, Iwasaki, Motoki, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jones, Michael E, Jung, Audrey, Kaaks, Rudolf, Kang, Daehee, Khusnutdinova, Elza K, Kim, Sung-Won, Kitahara, Cari M, Koutros, Stella, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, Kurian, Allison W, Kwong, Ava, Lacey, James V, Lambrechts, Diether, and Le Marchand, Loic

Subjects
Breast Cancer, Genetics, Clinical Research, Cancer, Aetiology, 2.1 Biological and endogenous factors, Humans, Female, Breast Neoplasms, Genetic Predisposition to Disease, Black People, Genetic Testing, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Formins, Breast cancer susceptibility, Diverse ancestry, Rare variants, Gene regulation, Genome-wide association study, NBCS Collaborators, CTS Consortium, ABCTB Investigators, Clinical Sciences
Abstract

BackgroundLow-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.MethodsWe evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.ResultsIn European ancestry samples, 14 genes were significantly associated (q

Published
2023

6. Circulating inflammatory and immune response proteins and endometrial cancer risk: a nested case-control study and Mendelian randomization analyses

Author

Wang, Sabrina E., Viallon, Vivian, Lee, Matthew, Dimou, Niki, Hamilton, Fergus, Biessy, Carine, O'Mara, Tracy, Kyrgiou, Maria, Crosbie, Emma J., Truong, Therese, Severi, Gianluca, Kaaks, Rudolf, Fortner, Renée Turzanski, Schulze, Matthias B., Bendinelli, Benedetta, Sabina, Sieri, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Crous-Bou, Marta, Sánchez, Maria-Jose, Aizpurua, Amaia, Palacios, Daniel Rodriguez, Guevara, Marcela, Travis, Ruth C., Tsilidis, Konstantinos K., Heath, Alicia, Yarmolinsky, James, Rinaldi, Sabina, Gunter, Marc J., and Dossus, Laure

Published
2024
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7. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries: results from the EPIC cohort study

Author

Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio

Published
2023
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8. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

Author

Christakoudi, Sofia, Tsilidis, Konstantinos K., Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S., Dahm, Christina C., Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M., Monninkhof, Evelyn M., Quirós, J. Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H., Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K., Aglago, Elom K., Peruchet-Noray, Laia, Freisling, Heinz, and Riboli, Elio

Published
2023
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9. BMI and breast cancer risk around age at menopause

Author

Von Holle, Ann, Adami, Hans-Olov, Baglietto, Laura, Berrington de Gonzalez, Amy, Bertrand, Kimberly A., Blot, William, Chen, Yu, DeHart, Jessica Clague, Dossus, Laure, Eliassen, A. Heather, Fournier, Agnes, Garcia-Closas, Montse, Giles, Graham, Guevara, Marcela, Hankinson, Susan E., Heath, Alicia, Jones, Michael E., Joshu, Corinne E., Kaaks, Rudolf, Kirsh, Victoria A., Kitahara, Cari M., Koh, Woon-Puay, Linet, Martha S., Park, Hannah Lui, Masala, Giovanna, Mellemkjaer, Lene, Milne, Roger L., O'Brien, Katie M., Palmer, Julie R., Riboli, Elio, Rohan, Thomas E., Shrubsole, Martha J., Sund, Malin, Tamimi, Rulla, Tin Tin, Sandar, Visvanathan, Kala, Vermeulen, Roel CH, Weiderpass, Elisabete, Willett, Walter C., Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Nichols, Hazel B., Sandler, Dale P., Swerdlow, Anthony J., Schoemaker, Minouk J., and Weinberg, Clarice R.

Published
2024
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10. Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women

Author

Wang, Xiaoliang, Kapoor, Pooja Middha, Auer, Paul L, Dennis, Joe, Dunning, Alison M, Wang, Qin, Lush, Michael, Michailidou, Kyriaki, Bolla, Manjeet K, Aronson, Kristan J, Murphy, Rachel A, Brooks-Wilson, Angela, Lee, Derrick G, Cordina-Duverger, Emilie, Guénel, Pascal, Truong, Thérèse, Mulot, Claire, Teras, Lauren R, Patel, Alpa V, Dossus, Laure, Kaaks, Rudolf, Hoppe, Reiner, Lo, Wing-Yee, Brüning, Thomas, Hamann, Ute, Czene, Kamila, Gabrielson, Marike, Hall, Per, Eriksson, Mikael, Jung, Audrey, Becher, Heiko, Couch, Fergus J, Larson, Nicole L, Olson, Janet E, Ruddy, Kathryn J, Giles, Graham G, MacInnis, Robert J, Southey, Melissa C, Le Marchand, Loic, Wilkens, Lynne R, Haiman, Christopher A, Olsson, Håkan, Augustinsson, Annelie, Krüger, Ute, Wagner, Philippe, Scott, Christopher, Winham, Stacey J, Vachon, Celine M, Perou, Charles M, Olshan, Andrew F, Troester, Melissa A, Hunter, David J, Eliassen, Heather A, Tamimi, Rulla M, Brantley, Kristen, Andrulis, Irene L, Figueroa, Jonine, Chanock, Stephen J, Ahearn, Thomas U, García-Closas, Montserrat, Evans, Gareth D, Newman, William G, van Veen, Elke M, Howell, Anthony, Wolk, Alicja, Håkansson, Niclas, Anton-Culver, Hoda, Ziogas, Argyrios, Jones, Michael E, Orr, Nick, Schoemaker, Minouk J, Swerdlow, Anthony J, Kitahara, Cari M, Linet, Martha, Prentice, Ross L, Easton, Douglas F, Milne, Roger L, Kraft, Peter, Chang-Claude, Jenny, and Lindström, Sara

Subjects
Genetics, Cancer, Aging, Human Genome, Breast Cancer, Prevention, Estrogen, 2.1 Biological and endogenous factors, Aetiology, Breast, Breast Neoplasms, Estrogen Replacement Therapy, Female, Hormone Replacement Therapy, Humans, Male, Menopause, Risk Factors
Abstract

Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully understood. We conducted a genome-wide interaction analysis between MHT use and genetic variants for breast cancer risk in 27,585 cases and 34,785 controls from 26 observational studies. All women were post-menopausal and of European ancestry. Multivariable logistic regression models were used to test for multiplicative interactions between genetic variants and current MHT use. We considered interaction p-values

Published
2022

11. Rare germline copy number variants (CNVs) and breast cancer risk

Author

Dennis, Joe, Tyrer, Jonathan P, Walker, Logan C, Michailidou, Kyriaki, Dorling, Leila, Bolla, Manjeet K, Wang, Qin, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Freeman, Laura E Beane, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bogdanova, Natalia V, Bojesen, Stig E, Brenner, Hermann, Castelao, Jose E, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Clarke, Christine L, Collée, J Margriet, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Devilee, Peter, Dörk, Thilo, Dossus, Laure, Eliassen, A Heather, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, García-Closas, Montserrat, Giles, Graham G, González-Neira, Anna, Guénel, Pascal, Hahnen, Eric, Haiman, Christopher A, Hall, Per, Hollestelle, Antoinette, Hoppe, Reiner, Hopper, John L, Howell, Anthony, Jager, Agnes, Jakubowska, Anna, John, Esther M, Johnson, Nichola, Jones, Michael E, Jung, Audrey, Kaaks, Rudolf, Keeman, Renske, Khusnutdinova, Elza, Kitahara, Cari M, Ko, Yon-Dschun, Kosma, Veli-Matti, Koutros, Stella, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, Kurian, Allison W, Lacey, James V, Lambrechts, Diether, Larson, Nicole L, Linet, Martha, Ogrodniczak, Alicja, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Mavroudis, Dimitrios, Milne, Roger L, Muranen, Taru A, Murphy, Rachel A, Nevanlinna, Heli, Olson, Janet E, Olsson, Håkan, Park-Simon, Tjoung-Won, Perou, Charles M, Peterlongo, Paolo, Plaseska-Karanfilska, Dijana, Pylkäs, Katri, Rennert, Gad, Saloustros, Emmanouil, Sandler, Dale P, Sawyer, Elinor J, Schmidt, Marjanka K, Schmutzler, Rita K, Shibli, Rana, Smeets, Ann, and Soucy, Penny

Subjects
Human Genome, Breast Cancer, Genetics, Clinical Research, Cancer, Prevention, 2.1 Biological and endogenous factors, Aetiology, Breast Neoplasms, Case-Control Studies, DNA Copy Number Variations, Female, Genome, Human, Genome-Wide Association Study, Germ Cells, Humans, Risk Factors, NBCS Collaborators, CTS Consortium, ABCTB Investigators, kConFab/AOCS Investigators
Abstract

Germline copy number variants (CNVs) are pervasive in the human genome but potential disease associations with rare CNVs have not been comprehensively assessed in large datasets. We analysed rare CNVs in genes and non-coding regions for 86,788 breast cancer cases and 76,122 controls of European ancestry with genome-wide array data. Gene burden tests detected the strongest association for deletions in BRCA1 (P = 3.7E-18). Nine other genes were associated with a p-value

Published
2022

12. Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Author

Morra, Anna, Escala-Garcia, Maria, Beesley, Jonathan, Keeman, Renske, Canisius, Sander, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Auer, Paul L, Augustinsson, Annelie, Beane Freeman, Laura E, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Bojesen, Stig E, Bolla, Manjeet K, Brenner, Hermann, Brüning, Thomas, Buys, Saundra S, Caan, Bette, Campa, Daniele, Canzian, Federico, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Cheng, Ting-Yuan David, Clarke, Christine L, Colonna, Sarah V, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Dennis, Joe, Dörk, Thilo, Dossus, Laure, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Flyger, Henrik, Fritschi, Lin, Gago-Dominguez, Manuela, García-Sáenz, José A, Giles, Graham G, Grip, Mervi, Guénel, Pascal, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hart, Steven N, Hartikainen, Jaana M, Hartmann, Arndt, He, Wei, Hooning, Maartje J, Hoppe, Reiner, Hopper, John L, Howell, Anthony, Hunter, David J, Jager, Agnes, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey Y, Kaaks, Rudolf, Keupers, Machteld, Kitahara, Cari M, Koutros, Stella, Kraft, Peter, Kristensen, Vessela N, Kurian, Allison W, Lacey, James V, Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Linet, Martha, Luben, Robert N, Lubiński, Jan, Lush, Michael, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Martens, John WM, Martinez, Maria Elena, Mavroudis, Dimitrios, Michailidou, Kyriaki, Milne, Roger L, Mulligan, Anna Marie, Muranen, Taru A, Nevanlinna, Heli, Newman, William G, and Nielsen, Sune F

Subjects
Clinical Research, Cancer, Breast Cancer, Human Genome, Genetics, 2.1 Biological and endogenous factors, Aetiology, Breast Neoplasms, Female, Genome-Wide Association Study, Germ-Line Mutation, Humans, Polymorphism, Single Nucleotide, Prognosis, Survival Analysis, Common germline genetic variants, Breast cancer-specific survival, Patient subgroups, Tumor biology, Systemic treatment, NBCS Collaborators, ABCTB Investigators, kConFab Investigators, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundGiven the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients.MethodsWe performed genome-wide association analyses within 15 subgroups of breast cancer patients based on prognostic factors, including hormone receptors, tumor grade, age, and type of systemic treatment. Analyses were based on 91,686 female patients of European ancestry from the Breast Cancer Association Consortium, including 7531 breast cancer-specific deaths over a median follow-up of 8.1 years. Cox regression was used to assess associations of common germline variants with 15-year and 5-year breast cancer-specific survival. We assessed the probability of these associations being true positives via the Bayesian false discovery probability (BFDP

Published
2021

13. Adulthood dietary and lifestyle patterns and risk of breast cancer: Global Cancer Update Programme (CUP Global) systematic literature review

Author

Konieczna, Jadwiga, Chaplin, Alice, Paz-Graniel, Indira, Croker, Helen, Becerra-Tomás, Nerea, Markozannes, Georgios, Tsilidis, Konstantinos K, Dossus, Laure, Gonzalez-Gil, Esther M, Park, Yikyung, Krebs, John, Weijenberg, Matty P, Baskin, Monica L, Copson, Ellen, Lewis, Sarah J, Seidell, Jacob C, Chowdhury, Rajiv, Hill, Lynette, Chan, Doris SM, and Romaguera, Dora

Published
2024
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14. The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study

Author

Bonet, Catalina, Crous-Bou, Marta, Tsilidis, Konstantinos K., Gunter, Marc J., Kaaks, Rudolf, Schulze, Matthias B., Fortner, Renée T., Antoniussen, Christian S., Dahm, Christina C., Mellemkjær, Lene, Tjønneland, Anne, Amiano, Pilar, Ardanaz, Eva, Colorado-Yohar, Sandra M., Rodriguez-Barranco, Miguel, Tin Tin, Sandar, Agnoli, Claudia, Masala, Giovanna, Panico, Salvatore, Sacerdote, Carlotta, May, Anne M., Borch, Kristin Benjaminsen, Rylander, Charlotta, Skeie, Guri, Christakoudi, Sofia, Aune, Dagfinn, Weiderpass, Elisabete, Dossus, Laure, Riboli, Elio, and Agudo, Antonio

Published
2023
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15. Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study

Author

Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Katzke, Verena, Le Cornet, Charlotte, Jannasch, Franziska, Schulze, Matthias B., Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Antoniussen, Christian S., Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, De Magistris, Maria Santucci, Sund, Malin, Bodén, Stina, Jensen, Torill Enget, Olsen, Karina Standahl, Skeie, Guri, Gunter, Marc J., Rinaldi, Sabina, Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Christakoudi, Sofia, Heath, Alicia K., Dossus, Laure, and Agudo, Antonio

Published
2023
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16. Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study

Author

Hughes, David J., Schomburg, Lutz, Jenab, Mazda, Biessy, Carine, Méplan, Catherine, Moskal, Aurelie, Sun, Qian, Demircan, Kamil, Fedirko, Veronika, Weiderpass, Elisabete, Mukhtar, Maryam, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Schulze, Matthias, Nøst, Therese Haugdahl, Skeie, Guri, Olsen, Karina Standahl, Ricceri, Fulvio, Grioni, Sara, Palli, Domenico, Masala, Giovanna, Tumino, Rosario, Pasanisi, Fabrizio, Amiano, Pilar, Colorado Yohar, Sandra M., Agudo, Antonio, Sánchez, Maria-Jose, Ardanaz, Eva, Sund, Malin, Andersson, Anne, Perez-Cornago, Aurora, Travis, Ruth, Heath, Alicia K., and Dossus, Laure

Published
2023
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17. Circulating vitamin D and breast cancer risk: an international pooling project of 17 cohorts

Author

Visvanathan, Kala, Mondul, Alison M., Zeleniuch-Jacquotte, Anne, Wang, Molin, Gail, Mitchell H., Yaun, Shiaw-Shyuan, Weinstein, Stephanie J., McCullough, Marjorie L., Eliassen, A. Heather, Cook, Nancy R., Agnoli, Claudia, Almquist, Martin, Black, Amanda, Buring, Julie E., Chen, Chu, Chen, Yu, Clendenen, Tess, Dossus, Laure, Fedirko, Veronika, Gierach, Gretchen L., Giovannucci, Edward L., Goodman, Gary E., Goodman, Marc T., Guénel, Pascal, Hallmans, Göran, Hankinson, Susan E., Horst, Ronald L., Hou, Tao, Huang, Wen-Yi, Jones, Michael E., Joshu, Corrine E., Kaaks, Rudolf, Krogh, Vittorio, Kühn, Tilman, Kvaskoff, Marina, Lee, I-Min, Mahamat-Saleh, Yahya, Malm, Johan, Manjer, Jonas, Maskarinec, Gertraud, Millen, Amy E., Mukhtar, Toqir K., Neuhouser, Marian L., Robsahm, Trude E., Schoemaker, Minouk J., Sieri, Sabina, Sund, Malin, Swerdlow, Anthony J., Thomson, Cynthia A., Ursin, Giske, Wactawski-Wende, Jean, Wang, Ying, Wilkens, Lynne R., Wu, Yujie, Zoltick, Emilie, Willett, Walter C., Smith-Warner, Stephanie A., and Ziegler, Regina G.

Published
2023
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18. Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R., Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M.A., Verschuren, W.M. Monique, Enget Jensen, Torill M., Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J. Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K., Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, and Truong, Thérèse

Published
2023
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20. Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Lécuyer, Lucie, Laouali, Nasser, Dossus, Laure, Shivappa, Nitin, Hébert, James R., Agudo, Antonio, Tjonneland, Anne, Halkjaer, Jytte, Overvad, Kim, Katzke, Verena A., Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Dragna, Luca, Iannuzzo, Gabriella, Jensen, Torill Enget, Brustad, Magritt, Skeie, Guri, Zamora-Ros, Raul, Rodriguez-Barranco, Miguel, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Almquist, Martin, Sonestedt, Emily, Sandström, Maria, Nilsson, Lena Maria, Weiderpass, Elisabete, Huybrechts, Inge, Rinaldi, Sabina, Boutron-Ruault, Marie-Christine, and Truong, Thérèse

Published
2022
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21. Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer

Author

Mukama, Trasias, Fortner, Renée Turzanski, Katzke, Verena, Hynes, Lucas Cory, Petrera, Agnese, Hauck, Stefanie M., Johnson, Theron, Schulze, Matthias, Schiborn, Catarina, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Overvad, Kim, Pérez, María José Sánchez, Crous-Bou, Marta, Chirlaque, María-Dolores, Amiano, Pilar, Ardanaz, Eva, Watts, Eleanor L., Travis, Ruth C., Sacerdote, Carlotta, Grioni, Sara, Masala, Giovanna, Signoriello, Simona, Tumino, Rosario, Gram, Inger T., Sandanger, Torkjel M., Sartor, Hanna, Lundin, Eva, Idahl, Annika, Heath, Alicia K., Dossus, Laure, Weiderpass, Elisabete, and Kaaks, Rudolf

Published
2022
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23. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian

Published
2022
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24. Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort

Author

Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure

Published
2022
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25. Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis

Author

Bouras, Emmanouil, Karhunen, Ville, Gill, Dipender, Huang, Jian, Haycock, Philip C., Gunter, Marc J., Johansson, Mattias, Brennan, Paul, Key, Tim, Lewis, Sarah J., Martin, Richard M., Murphy, Neil, Platz, Elizabeth A., Travis, Ruth, Yarmolinsky, James, Zuber, Verena, Martin, Paul, Katsoulis, Michail, Freisling, Heinz, Nøst, Therese Haugdahl, Schulze, Matthias B., Dossus, Laure, Hung, Rayjean J., Amos, Christopher I., Ahola-Olli, Ari, Palaniswamy, Saranya, Männikkö, Minna, Auvinen, Juha, Herzig, Karl-Heinz, Keinänen-Kiukaanniemi, Sirkka, Lehtimäki, Terho, Salomaa, Veikko, Raitakari, Olli, Salmi, Marko, Jalkanen, Sirpa, Jarvelin, Marjo-Riitta, Dehghan, Abbas, and Tsilidis, Konstantinos K.

Published
2022
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29. BMI and breast cancer risk around age at menopause

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Von Holle, Ann, Adami, Hans-Olov, Baglietto, Laura, Berrington, Amy, Bertrand, Kimberly A, Blot, William, Chen, Yu, DeHart, Jessica Clague, Dossus, Laure, Eliassen, A Heather, Fournier, Agnes, Garcia-Closas, Montse, Giles, Graham, Guevara, Marcela, Hankinson, Susan E, Heath, Alicia, Jones, Michael E, Joshu, Corinne E, Kaaks, Rudolf, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Linet, Martha S, Park, Hannah Lui, Masala, Giovanna, Mellemkjaer, Lene, Milne, Roger L, O'Brien, Katie M, Palmer, Julie R, Riboli, Elio, Rohan, Thomas E, Shrubsole, Martha J, Sund, Malin, Tamimi, Rulla, Tin Tin, Sandar, Visvanathan, Kala, Vermeulen, Roel Ch, Weiderpass, Elisabete, Willett, Walter C, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Nichols, Hazel B, Sandler, Dale P, Swerdlow, Anthony J, Schoemaker, Minouk J, Weinberg, Clarice R, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Von Holle, Ann, Adami, Hans-Olov, Baglietto, Laura, Berrington, Amy, Bertrand, Kimberly A, Blot, William, Chen, Yu, DeHart, Jessica Clague, Dossus, Laure, Eliassen, A Heather, Fournier, Agnes, Garcia-Closas, Montse, Giles, Graham, Guevara, Marcela, Hankinson, Susan E, Heath, Alicia, Jones, Michael E, Joshu, Corinne E, Kaaks, Rudolf, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Linet, Martha S, Park, Hannah Lui, Masala, Giovanna, Mellemkjaer, Lene, Milne, Roger L, O'Brien, Katie M, Palmer, Julie R, Riboli, Elio, Rohan, Thomas E, Shrubsole, Martha J, Sund, Malin, Tamimi, Rulla, Tin Tin, Sandar, Visvanathan, Kala, Vermeulen, Roel Ch, Weiderpass, Elisabete, Willett, Walter C, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Nichols, Hazel B, Sandler, Dale P, Swerdlow, Anthony J, Schoemaker, Minouk J, and Weinberg, Clarice R

Published
2024

30. Post-diagnosis adiposity and colorectal cancer prognosis:A Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis

Author

Becerra-Tomás, Nerea, Markozannes, Georgios, Cariolou, Margarita, Balducci, Katia, Vieira, Rita, Kiss, Sonia, Aune, Dagfinn, Greenwood, Darren C., Dossus, Laure, Copson, Ellen, Renehan, Andrew G., Bours, Martijn, Demark-Wahnefried, Wendy, Hudson, Melissa M., May, Anne M., Odedina, Folakemi T., Skinner, Roderick, Steindorf, Karen, Tjønneland, Anne, Velikova, Galina, Baskin, Monica L., Chowdhury, Rajiv, Hill, Lynette, Lewis, Sarah J., Seidell, Jaap, Weijenberg, Matty P., Krebs, John, Cross, Amanda J., Tsilidis, Konstantinos K., Chan, Doris S.M., Becerra-Tomás, Nerea, Markozannes, Georgios, Cariolou, Margarita, Balducci, Katia, Vieira, Rita, Kiss, Sonia, Aune, Dagfinn, Greenwood, Darren C., Dossus, Laure, Copson, Ellen, Renehan, Andrew G., Bours, Martijn, Demark-Wahnefried, Wendy, Hudson, Melissa M., May, Anne M., Odedina, Folakemi T., Skinner, Roderick, Steindorf, Karen, Tjønneland, Anne, Velikova, Galina, Baskin, Monica L., Chowdhury, Rajiv, Hill, Lynette, Lewis, Sarah J., Seidell, Jaap, Weijenberg, Matty P., Krebs, John, Cross, Amanda J., Tsilidis, Konstantinos K., and Chan, Doris S.M.

Abstract

The adiposity influence on colorectal cancer prognosis remains poorly characterised. We performed a systematic review and meta-analysis on post-diagnosis adiposity measures (body mass index [BMI], waist circumference, waist-to-hip ratio, weight) or their changes and colorectal cancer outcomes. PubMed and Embase were searched through 28 February 2022. Random-effects meta-analyses were conducted when at least three studies had sufficient information. The quality of evidence was interpreted and graded by the Global Cancer Update Programme (CUP Global) independent Expert Committee on Cancer Survivorship and Expert Panel. We reviewed 124 observational studies (85 publications). Meta-analyses were possible for BMI and all-cause mortality, colorectal cancer-specific mortality, and cancer recurrence/disease-free survival. Non-linear meta-analysis indicated a reverse J-shaped association between BMI and colorectal cancer outcomes (nadir at BMI 28 kg/m2). The highest risk, relative to the nadir, was observed at both ends of the BMI distribution (18 and 38 kg/m2), namely 60% and 23% higher risk for all-cause mortality; 95% and 26% for colorectal cancer-specific mortality; and 37% and 24% for cancer recurrence/disease-free survival, respectively. The higher risk with low BMI was attenuated in secondary analyses of RCTs (compared to cohort studies), among studies with longer follow-up, and in women suggesting potential methodological limitations and/or altered physiological state. Descriptively synthesised studies on other adiposity-outcome associations of interest were limited in number and methodological quality. All the associations were graded as limited (likelihood of causality: no conclusion) due to potential methodological limitations (reverse causation, confounding, selection bias). Additional well-designed observational studies and interventional trials are needed to provide further clarification., The adiposity influence on colorectal cancer prognosis remains poorly characterised. We performed a systematic review and meta-analysis on post-diagnosis adiposity measures (body mass index [BMI], waist circumference, waist-to-hip ratio, weight) or their changes and colorectal cancer outcomes. PubMed and Embase were searched through 28 February 2022. Random-effects meta-analyses were conducted when at least three studies had sufficient information. The quality of evidence was interpreted and graded by the Global Cancer Update Programme (CUP Global) independent Expert Committee on Cancer Survivorship and Expert Panel. We reviewed 124 observational studies (85 publications). Meta-analyses were possible for BMI and all-cause mortality, colorectal cancer-specific mortality, and cancer recurrence/disease-free survival. Non-linear meta-analysis indicated a reverse J-shaped association between BMI and colorectal cancer outcomes (nadir at BMI 28 kg/m2). The highest risk, relative to the nadir, was observed at both ends of the BMI distribution (18 and 38 kg/m2), namely 60% and 23% higher risk for all-cause mortality; 95% and 26% for colorectal cancer-specific mortality; and 37% and 24% for cancer recurrence/disease-free survival, respectively. The higher risk with low BMI was attenuated in secondary analyses of RCTs (compared to cohort studies), among studies with longer follow-up, and in women suggesting potential methodological limitations and/or altered physiological state. Descriptively synthesised studies on other adiposity-outcome associations of interest were limited in number and methodological quality. All the associations were graded as limited (likelihood of causality: no conclusion) due to potential methodological limitations (reverse causation, confounding, selection bias). Additional well-designed observational studies and interventional trials are needed to provide further clarification.

Published
2024

31. Post-diagnosis adiposity, physical activity, sedentary behaviour, dietary factors, supplement use and colorectal cancer prognosis:Global Cancer Update Programme (CUP Global) summary of evidence grading

Author

Tsilidis, Konstantinos K., Markozannes, Georgios, Becerra-Tomás, Nerea, Cariolou, Margarita, Balducci, Katia, Vieira, Rita, Kiss, Sonia, Aune, Dagfinn, Greenwood, Darren C., Dossus, Laure, González-Gil, Esther M., Gunter, Marc J., Allen, Kate, Brockton, Nigel T., Croker, Helen, Gordon-Dseagu, Vanessa L., Mitrou, Panagiota, Musuwo, Nicole, Wiseman, Martin J., Copson, Ellen, Renehan, Andrew G., Bours, Martijn, Demark-Wahnefried, Wendy, Hudson, Melissa M., May, Anne M., Odedina, Folakemi T., Skinner, Roderick, Steindorf, Karen, Tjønneland, Anne, Velikova, Galina, Baskin, Monica L., Chowdhury, Rajiv, Hill, Lynette, Lewis, Sarah J., Seidell, Jaap, Weijenberg, Matty P., Krebs, John, Cross, Amanda J., Chan, Doris S.M., Tsilidis, Konstantinos K., Markozannes, Georgios, Becerra-Tomás, Nerea, Cariolou, Margarita, Balducci, Katia, Vieira, Rita, Kiss, Sonia, Aune, Dagfinn, Greenwood, Darren C., Dossus, Laure, González-Gil, Esther M., Gunter, Marc J., Allen, Kate, Brockton, Nigel T., Croker, Helen, Gordon-Dseagu, Vanessa L., Mitrou, Panagiota, Musuwo, Nicole, Wiseman, Martin J., Copson, Ellen, Renehan, Andrew G., Bours, Martijn, Demark-Wahnefried, Wendy, Hudson, Melissa M., May, Anne M., Odedina, Folakemi T., Skinner, Roderick, Steindorf, Karen, Tjønneland, Anne, Velikova, Galina, Baskin, Monica L., Chowdhury, Rajiv, Hill, Lynette, Lewis, Sarah J., Seidell, Jaap, Weijenberg, Matty P., Krebs, John, Cross, Amanda J., and Chan, Doris S.M.

Abstract

Based on the World Cancer Research Fund Global Cancer Update Programme, we performed systematic reviews and meta-analyses to investigate the association of post-diagnosis adiposity, physical activity, sedentary behaviour, and dietary factors with colorectal cancer prognosis. We searched PubMed and Embase until 28th February, 2022. An independent expert committee and expert panel graded the quality of evidence. A total of 167 unique publications were reviewed, and all but five were observational studies. The quality of the evidence was graded conservatively due to the high risk of several biases. There was evidence of non-linearity in the associations between body mass index and colorectal cancer prognosis. The associations appeared reverse J-shaped, and the quality of this evidence was graded as limited (likelihood of causality: limited-no conclusion). The evidence on recreational physical activity and lower risk of all-cause mortality (relative risk [RR] highest vs. lowest: 0.69, 95% confidence interval [CI]: 0.62–0.77) and recurrence/disease-free survival (RR: 0.80, 95% CI: 0.70–0.92) was graded as limited-suggestive. There was limited-suggestive evidence for the associations between healthy dietary and/or lifestyle patterns (including diets that comprised plant-based foods), intake of whole grains and coffee with lower risk of all-cause mortality, and between unhealthy dietary patterns and intake of sugary drinks with higher risk of all-cause mortality. The evidence for other exposures on colorectal cancer outcomes was sparse and graded as limited-no conclusion. Analyses were conducted excluding cancer patients with metastases without substantial changes in the findings. Well-designed intervention and cohort studies are needed to support the development of lifestyle recommendations for colorectal cancer patients., Based on the World Cancer Research Fund Global Cancer Update Programme, we performed systematic reviews and meta-analyses to investigate the association of post-diagnosis adiposity, physical activity, sedentary behaviour, and dietary factors with colorectal cancer prognosis. We searched PubMed and Embase until 28th February, 2022. An independent expert committee and expert panel graded the quality of evidence. A total of 167 unique publications were reviewed, and all but five were observational studies. The quality of the evidence was graded conservatively due to the high risk of several biases. There was evidence of non-linearity in the associations between body mass index and colorectal cancer prognosis. The associations appeared reverse J-shaped, and the quality of this evidence was graded as limited (likelihood of causality: limited-no conclusion). The evidence on recreational physical activity and lower risk of all-cause mortality (relative risk [RR] highest vs. lowest: 0.69, 95% confidence interval [CI]: 0.62–0.77) and recurrence/disease-free survival (RR: 0.80, 95% CI: 0.70–0.92) was graded as limited-suggestive. There was limited-suggestive evidence for the associations between healthy dietary and/or lifestyle patterns (including diets that comprised plant-based foods), intake of whole grains and coffee with lower risk of all-cause mortality, and between unhealthy dietary patterns and intake of sugary drinks with higher risk of all-cause mortality. The evidence for other exposures on colorectal cancer outcomes was sparse and graded as limited-no conclusion. Analyses were conducted excluding cancer patients with metastases without substantial changes in the findings. Well-designed intervention and cohort studies are needed to support the development of lifestyle recommendations for colorectal cancer patients.

Published
2024

32. Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women

Author

Rinaldi, Sabina, Dossus, Laure, Keski-Rahkonen, Pekka, Kiss, Agneta, Navionis, Anne-Sophie, Biessy, Carine, Travis, Ruth, Weiderpass, Elisabete, Romieu, Isabelle, Eriksen, Anne Kirstine, Tjonneland, Anne, Kvaskoff, Marina, Canonico, Marianne, Truong, Thérèse, Katzke, Verena, Kaaks, Rudolf, Catalano, Alberto, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Lukic, Marko, Olsen, Karina Standahl, Zamora-Ros, Raul, Santiuste, Carmen, Aizpurua Atxega, Amaia, Guevara, Marcela, Rodriguez-Barranco, Miguel, Sandstrom, Maria, Hennings, Joakim, Almquist, Martin, Aglago Kouassivi, Elom, Christakoudi, Sofia, Gunter, Marc, Franceschi, Silvia, Rinaldi, Sabina, Dossus, Laure, Keski-Rahkonen, Pekka, Kiss, Agneta, Navionis, Anne-Sophie, Biessy, Carine, Travis, Ruth, Weiderpass, Elisabete, Romieu, Isabelle, Eriksen, Anne Kirstine, Tjonneland, Anne, Kvaskoff, Marina, Canonico, Marianne, Truong, Thérèse, Katzke, Verena, Kaaks, Rudolf, Catalano, Alberto, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Lukic, Marko, Olsen, Karina Standahl, Zamora-Ros, Raul, Santiuste, Carmen, Aizpurua Atxega, Amaia, Guevara, Marcela, Rodriguez-Barranco, Miguel, Sandstrom, Maria, Hennings, Joakim, Almquist, Martin, Aglago Kouassivi, Elom, Christakoudi, Sofia, Gunter, Marc, and Franceschi, Silvia

Abstract

Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre-menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1: 1.68, 95% CI: 0.96–2.92, ptrend = .06) and androstenedione concentrations in pre/perimenopausal women (adjusted OR T3 vs T1: 1.78, 95% CI: 0.96–3.30, ptrend = .06, respectively). A borderline decrease in risk was observed for the highest progesterone/estradiol ratio (adjusted OR T3 vs T1: 0.54, 95% CI: 0.28–1.05, ptrend = .07). Overall, our results do not support a major role of circulating sex steroids in the etiology of differentiated TC in post-menopausal women and men but may suggest an involvement of altered sex steroid production in pre-menopausal women., Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre-menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1: 1.68, 95% CI: 0.96-2.92, ptrend = .06) and androstenedione concentrations in pre/perimenopausal women (adjusted OR T3 vs T1: 1.78, 95% CI: 0.96-3.30, ptrend = .06, respectively). A borderline decrease in risk was observed for the highest progesterone/estradiol ratio (adjusted OR T3 vs T1: 0.54, 95% CI: 0.28-1.05, ptrend = .07). Overall, our results do not support a major role of circulating sex steroids in the etiology of differentiated TC in post-menopausal women and men but may suggest an involvement of altered sex steroid production in pre-menopausal women.

Published
2024

33. Lifestyle changes in middle age and risk of cancer:evidence from the European Prospective Investigation into Cancer and Nutrition

Author

Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Hoff, Geir, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Dossus, Laure, Johansson, Mattias, Freisling, Heinz, Matta, Komodo, Huybrechts, Inge, Chen, Sairah L.F., B. Borch, Kristin, Sandanger, Torkjel M., H. Nøst, Therese, Dahm, Christina C., Antoniussen, Christian S., Tin Tin, Sandar, Fournier, Agnès, Marques, Chloé, Artaud, Fanny, Sánchez, Maria José, Guevara, Marcela, Santiuste, Carmen, Agudo, Antonio, Bajracharya, Rashmita, Katzke, Verena, Ricceri, Fulvio, Agnoli, Claudia, Bergmann, Manuela M., Schulze, Matthias B., Panico, Salvatore, Masala, Giovanna, Tjønneland, Anne, Olsen, Anja, Stocks, Tanja, Manjer, Jonas, Aizpurua-Atxega, Amaia, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Ferrari, Pietro, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Hoff, Geir, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Dossus, Laure, Johansson, Mattias, Freisling, Heinz, Matta, Komodo, Huybrechts, Inge, Chen, Sairah L.F., B. Borch, Kristin, Sandanger, Torkjel M., H. Nøst, Therese, Dahm, Christina C., Antoniussen, Christian S., Tin Tin, Sandar, Fournier, Agnès, Marques, Chloé, Artaud, Fanny, Sánchez, Maria José, Guevara, Marcela, Santiuste, Carmen, Agudo, Antonio, Bajracharya, Rashmita, Katzke, Verena, Ricceri, Fulvio, Agnoli, Claudia, Bergmann, Manuela M., Schulze, Matthias B., Panico, Salvatore, Masala, Giovanna, Tjønneland, Anne, Olsen, Anja, Stocks, Tanja, Manjer, Jonas, Aizpurua-Atxega, Amaia, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., and Ferrari, Pietro

Abstract

In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged from 0 (most unfavourable) to 16 (most favourable). We estimated the association between HLI change and risk of lifestyle-related cancers—including cancer of the breast, lung, colorectum, stomach, liver, cervix, oesophagus, bladder, and others—using Cox regression models. We reported hazard ratios (HR) with 95% confidence intervals (CI). Median time between the two questionnaires was 5.7 years, median age at follow-up questionnaire was 59 years. After the follow-up questionnaire, we observed 14,933 lifestyle-related cancers over a median follow-up of 7.8 years. Each unit increase in the HLI score was associated with 4% lower risk of lifestyle-related cancers (HR 0.96; 95%CI 0.95–0.97). Among participants in the top HLI third at baseline (HLI > 11), those in the bottom third at follow-up (HLI ≤ 9) had 21% higher risk of lifestyle-related cancers (HR 1.21; 95%CI 1.07–1.37) than those remaining in the top third. Among participants in the bottom HLI third at baseline, those in the top third at follow-up had 25% lower risk of lifestyle-related cancers (HR 0.75; 95%CI 0.65–0.86) than those remaining in the bottom third. These results indicate that lifestyle changes in middle age may have a significant impact on cancer risk.

Published
2024

34. Post‐diagnosis adiposity, physical activity, sedentary behaviour, dietary factors, supplement use and colorectal cancer prognosis: Global Cancer Update Programme (CUP Global) summary of evidence grading.

Author

Tsilidis, Konstantinos K., Markozannes, Georgios, Becerra‐Tomás, Nerea, Cariolou, Margarita, Balducci, Katia, Vieira, Rita, Kiss, Sonia, Aune, Dagfinn, Greenwood, Darren C., Dossus, Laure, González‐Gil, Esther M., Gunter, Marc J., Allen, Kate, Brockton, Nigel T., Croker, Helen, Gordon‐Dseagu, Vanessa L., Mitrou, Panagiota, Musuwo, Nicole, Wiseman, Martin J., and Copson, Ellen

Subjects
SEDENTARY behavior, SOFT drinks, COLORECTAL cancer, PHYSICAL activity, CANCER prognosis, DIETARY patterns, CANCER of unknown primary origin
Abstract

Based on the World Cancer Research Fund Global Cancer Update Programme, we performed systematic reviews and meta‐analyses to investigate the association of post‐diagnosis adiposity, physical activity, sedentary behaviour, and dietary factors with colorectal cancer prognosis. We searched PubMed and Embase until 28th February, 2022. An independent expert committee and expert panel graded the quality of evidence. A total of 167 unique publications were reviewed, and all but five were observational studies. The quality of the evidence was graded conservatively due to the high risk of several biases. There was evidence of non‐linearity in the associations between body mass index and colorectal cancer prognosis. The associations appeared reverse J‐shaped, and the quality of this evidence was graded as limited (likelihood of causality: limited‐no conclusion). The evidence on recreational physical activity and lower risk of all‐cause mortality (relative risk [RR] highest vs. lowest: 0.69, 95% confidence interval [CI]: 0.62–0.77) and recurrence/disease‐free survival (RR: 0.80, 95% CI: 0.70–0.92) was graded as limited‐suggestive. There was limited‐suggestive evidence for the associations between healthy dietary and/or lifestyle patterns (including diets that comprised plant‐based foods), intake of whole grains and coffee with lower risk of all‐cause mortality, and between unhealthy dietary patterns and intake of sugary drinks with higher risk of all‐cause mortality. The evidence for other exposures on colorectal cancer outcomes was sparse and graded as limited‐no conclusion. Analyses were conducted excluding cancer patients with metastases without substantial changes in the findings. Well‐designed intervention and cohort studies are needed to support the development of lifestyle recommendations for colorectal cancer patients. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Post‐diagnosis adiposity and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis.

Author

Becerra‐Tomás, Nerea, Markozannes, Georgios, Cariolou, Margarita, Balducci, Katia, Vieira, Rita, Kiss, Sonia, Aune, Dagfinn, Greenwood, Darren C., Dossus, Laure, Copson, Ellen, Renehan, Andrew G., Bours, Martijn, Demark‐Wahnefried, Wendy, Hudson, Melissa M., May, Anne M., Odedina, Folakemi T., Skinner, Roderick, Steindorf, Karen, Tjønneland, Anne, and Velikova, Galina

Subjects
COLORECTAL cancer, CANCER prognosis, CANCER of unknown primary origin, OBESITY, WAIST-hip ratio, CANCER relapse, CLINICAL trials
Abstract

The adiposity influence on colorectal cancer prognosis remains poorly characterised. We performed a systematic review and meta‐analysis on post‐diagnosis adiposity measures (body mass index [BMI], waist circumference, waist‐to‐hip ratio, weight) or their changes and colorectal cancer outcomes. PubMed and Embase were searched through 28 February 2022. Random‐effects meta‐analyses were conducted when at least three studies had sufficient information. The quality of evidence was interpreted and graded by the Global Cancer Update Programme (CUP Global) independent Expert Committee on Cancer Survivorship and Expert Panel. We reviewed 124 observational studies (85 publications). Meta‐analyses were possible for BMI and all‐cause mortality, colorectal cancer‐specific mortality, and cancer recurrence/disease‐free survival. Non‐linear meta‐analysis indicated a reverse J‐shaped association between BMI and colorectal cancer outcomes (nadir at BMI 28 kg/m2). The highest risk, relative to the nadir, was observed at both ends of the BMI distribution (18 and 38 kg/m2), namely 60% and 23% higher risk for all‐cause mortality; 95% and 26% for colorectal cancer‐specific mortality; and 37% and 24% for cancer recurrence/disease‐free survival, respectively. The higher risk with low BMI was attenuated in secondary analyses of RCTs (compared to cohort studies), among studies with longer follow‐up, and in women suggesting potential methodological limitations and/or altered physiological state. Descriptively synthesised studies on other adiposity‐outcome associations of interest were limited in number and methodological quality. All the associations were graded as limited (likelihood of causality: no conclusion) due to potential methodological limitations (reverse causation, confounding, selection bias). Additional well‐designed observational studies and interventional trials are needed to provide further clarification. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women

Author

Rinaldi, Sabina, primary, Dossus, Laure, additional, Keski‐Rahkonen, Pekka, additional, Kiss, Agneta, additional, Navionis, Anne‐Sophie, additional, Biessy, Carine, additional, Travis, Ruth, additional, Weiderpass, Elisabete, additional, Romieu, Isabelle, additional, Eriksen, Anne Kirstine, additional, Tjonneland, Anne, additional, Kvaskoff, Marina, additional, Canonico, Marianne, additional, Truong, Thérèse, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Catalano, Alberto, additional, Panico, Salvatore, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Lukic, Marko, additional, Olsen, Karina Standahl, additional, Zamora‐Ros, Raul, additional, Santiuste, Carmen, additional, Aizpurua Atxega, Amaia, additional, Guevara, Marcela, additional, Rodriguez‐Barranco, Miguel, additional, Sandstrom, Maria, additional, Hennings, Joakim, additional, Almquist, Martin, additional, Aglago Kouassivi, Elom, additional, Christakoudi, Sofia, additional, Gunter, Marc, additional, and Franceschi, Silvia, additional

Published
2024
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37. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts

Author

Timmins, Iain R., primary, Jones, Michael E., additional, O'Brien, Katie M., additional, Adami, Hans-Olov, additional, Aune, Dagfinn, additional, Baglietto, Laura, additional, Bertrand, Kimberly A., additional, Brantley, Kristen D., additional, Chen, Yu, additional, Clague DeHart, Jessica, additional, Clendenen, Tess V., additional, Dossus, Laure, additional, Eliassen, A. Heather, additional, Fletcher, Olivia, additional, Fournier, Agnès, additional, Håkansson, Niclas, additional, Hankinson, Susan E., additional, Houlston, Richard S., additional, Joshu, Corinne E., additional, Kirsh, Victoria A., additional, Kitahara, Cari M., additional, Koh, Woon-Puay, additional, Linet, Martha S., additional, Park, Hannah Lui, additional, Lynch, Brigid M., additional, May, Anne M., additional, Mellemkjær, Lene, additional, Milne, Roger L., additional, Palmer, Julie R., additional, Ricceri, Fulvio, additional, Rohan, Thomas E., additional, Ruddy, Kathryn J., additional, Sánchez, Maria-Jose, additional, Shu, Xiao-Ou, additional, Smith-Byrne, Karl, additional, Steindorf, Karen, additional, Sund, Malin, additional, Vachon, Celine M., additional, Vatten, Lars J., additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Willett, Walter C., additional, Wolk, Alicja, additional, Yuan, Jian-Min, additional, Zheng, Wei, additional, Nichols, Hazel B., additional, Sandler, Dale P., additional, Swerdlow, Anthony J., additional, and Schoemaker, Minouk J., additional

Published
2023
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39. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort

Author

His, Mathilde, Viallon, Vivian, Dossus, Laure, Schmidt, Julie A., Travis, Ruth C., Gunter, Marc J., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Lécuyer, Lucie, Rothwell, Joseph A., Severi, Gianluca, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Macciotta, Alessandra, Boer, Jolanda M. A., Monninkhof, Evelyn M., Olsen, Karina Standahl, Nøst, Therese H., Sandanger, Torkjel M., Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Ardanaz, Eva, Vidman, Linda, Winkvist, Anna, Heath, Alicia K., Weiderpass, Elisabete, Huybrechts, Inge, and Rinaldi, Sabina

Published
2021
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40. Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition

Author

Kliemann, Nathalie, Viallon, Vivian, Murphy, Neil, Beeken, Rebecca J., Rothwell, Joseph A., Rinaldi, Sabina, Assi, Nada, van Roekel, Eline H., Schmidt, Julie A., Borch, Kristin Benjaminsen, Agnoli, Claudia, Rosendahl, Ann H., Sartor, Hanna, Huerta, José María, Tjønneland, Anne, Halkjær, Jytte, Bueno-de-Mesquita, Bas, Gicquiau, Audrey, Achaintre, David, Aleksandrova, Krasimira, Schulze, Matthias B., Heath, Alicia K., Tsilidis, Konstantinos K., Masala, Giovanna, Panico, Salvatore, Kaaks, Rudolf, Fortner, Renée T., Van Guelpen, Bethany, Dossus, Laure, Scalbert, Augustin, Keun, Hector C., Travis, Ruth C., Jenab, Mazda, Johansson, Mattias, Ferrari, Pietro, and Gunter, Marc J.

Published
2021
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42. Dietary intake of trans fatty acids and breast cancer risk in 9 European countries

Author

Matta, Michèle, Huybrechts, Inge, Biessy, Carine, Casagrande, Corinne, Yammine, Sahar, Fournier, Agnès, Olsen, Karina Standahl, Lukic, Marco, Gram, Inger Torhild, Ardanaz, Eva, Sánchez, Maria-José, Dossus, Laure, Fortner, Renée T., Srour, Bernard, Jannasch, Franziska, Schulze, Matthias B., Amiano, Pilar, Agudo, Antonio, Colorado-Yohar, Sandra, Quirós, J. Ramón, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Tjønneland, Anne, Olsen, Anja, Dahm, Christina C., Rosendahl, Ann H., Borgquist, Signe, Wennberg, Maria, Heath, Alicia K., Aune, Dagfinn, Schmidt, Julie, Weiderpass, Elisabete, Chajes, Veronique, Gunter, Marc J., and Murphy, Neil

Published
2021
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43. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts.

Author

Timmins, Iain R., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Aune, Dagfinn, Baglietto, Laura, Bertrand, Kimberly A., Brantley, Kristen D., Chen, Yu, Clague DeHart, Jessica, Clendenen, Tess V., Dossus, Laure, Eliassen, A. Heather, Fletcher, Olivia, Fournier, Agnès, Håkansson, Niclas, Hankinson, Susan E., Houlston, Richard S., Joshu, Corinne E., and Kirsh, Victoria A.

Published
2024
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47. Data from Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort

Author

Sarink, Danja, primary, Schock, Helena, primary, Johnson, Theron, primary, Overvad, Kim, primary, Holm, Marianne, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, His, Mathilde, primary, Kvaskoff, Marina, primary, Boeing, Heiner, primary, Lagiou, Pagona, primary, Papatesta, Eleni-Maria, primary, Trichopoulou, Antonia, primary, Palli, Domenico, primary, Pala, Valeria, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Bueno-de-Mesquita, H.B(as)., primary, van Gils, Carla H., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Agudo, Antonio, primary, Sánchez, Maria-José, primary, Chirlaque, Maria-Dolores, primary, Ardanaz, Eva, primary, Amiano, Pilar, primary, Khaw, Kay Tee, primary, Travis, Ruth, primary, Dossus, Laure, primary, Gunter, Mark, primary, Rinaldi, Sabina, primary, Merritt, Melissa, primary, Riboli, Elio, primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary

Published
2023
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48. Supplementary Figure Legend from Postmenopausal Serum Sex Steroids and Risk of Hormone Receptor–Positive and -Negative Breast Cancer: a Nested Case–Control Study

Author

James, Rebecca E., primary, Lukanova, Annekatrin, primary, Dossus, Laure, primary, Becker, Susen, primary, Rinaldi, Sabina, primary, Tjønneland, Anne, primary, Olsen, Anja, primary, Overvad, Kim, primary, Mesrine, Sylvie, primary, Engel, Pierre, primary, Clavel-Chapelon, Françoise, primary, Chang-Claude, Jenny, primary, Vrieling, Alina, primary, Boeing, Heiner, primary, Schütze, Madlen, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Palli, Domenico, primary, Krogh, Vittorio, primary, Panico, Salvatore, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Rodríguez, Laudina, primary, Buckland, Genevieve, primary, Sánchez, Maria-José, primary, Amiano, Pilar, primary, Ardanaz, Eva, primary, Bueno-de-Mesquita, Bas, primary, Ros, Martine M., primary, van Gils, Carla H., primary, Peeters, Petra H., primary, Khaw, Kay-Tee, primary, Wareham, Nick, primary, Key, Timothy J., primary, Allen, Naomi E., primary, Romieu, Isabelle, primary, Siddiq, Afshan, primary, Cox, David, primary, Riboli, Elio, primary, and Kaaks, Rudolf, primary

Published
2023
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49. Data from Postmenopausal Serum Sex Steroids and Risk of Hormone Receptor–Positive and -Negative Breast Cancer: a Nested Case–Control Study

Author

James, Rebecca E., primary, Lukanova, Annekatrin, primary, Dossus, Laure, primary, Becker, Susen, primary, Rinaldi, Sabina, primary, Tjønneland, Anne, primary, Olsen, Anja, primary, Overvad, Kim, primary, Mesrine, Sylvie, primary, Engel, Pierre, primary, Clavel-Chapelon, Françoise, primary, Chang-Claude, Jenny, primary, Vrieling, Alina, primary, Boeing, Heiner, primary, Schütze, Madlen, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Palli, Domenico, primary, Krogh, Vittorio, primary, Panico, Salvatore, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Rodríguez, Laudina, primary, Buckland, Genevieve, primary, Sánchez, Maria-José, primary, Amiano, Pilar, primary, Ardanaz, Eva, primary, Bueno-de-Mesquita, Bas, primary, Ros, Martine M., primary, van Gils, Carla H., primary, Peeters, Petra H., primary, Khaw, Kay-Tee, primary, Wareham, Nick, primary, Key, Timothy J., primary, Allen, Naomi E., primary, Romieu, Isabelle, primary, Siddiq, Afshan, primary, Cox, David, primary, Riboli, Elio, primary, and Kaaks, Rudolf, primary

Published
2023
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50. Supplementary Figure 1 from Postmenopausal Serum Sex Steroids and Risk of Hormone Receptor–Positive and -Negative Breast Cancer: a Nested Case–Control Study

Author

James, Rebecca E., primary, Lukanova, Annekatrin, primary, Dossus, Laure, primary, Becker, Susen, primary, Rinaldi, Sabina, primary, Tjønneland, Anne, primary, Olsen, Anja, primary, Overvad, Kim, primary, Mesrine, Sylvie, primary, Engel, Pierre, primary, Clavel-Chapelon, Françoise, primary, Chang-Claude, Jenny, primary, Vrieling, Alina, primary, Boeing, Heiner, primary, Schütze, Madlen, primary, Trichopoulou, Antonia, primary, Lagiou, Pagona, primary, Trichopoulos, Dimitrios, primary, Palli, Domenico, primary, Krogh, Vittorio, primary, Panico, Salvatore, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Rodríguez, Laudina, primary, Buckland, Genevieve, primary, Sánchez, Maria-José, primary, Amiano, Pilar, primary, Ardanaz, Eva, primary, Bueno-de-Mesquita, Bas, primary, Ros, Martine M., primary, van Gils, Carla H., primary, Peeters, Petra H., primary, Khaw, Kay-Tee, primary, Wareham, Nick, primary, Key, Timothy J., primary, Allen, Naomi E., primary, Romieu, Isabelle, primary, Siddiq, Afshan, primary, Cox, David, primary, Riboli, Elio, primary, and Kaaks, Rudolf, primary

Published
2023
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