Search

Your search keyword '"Doloy A"' showing total 16 results
Start Over Author "Doloy A" Publication Year Range Last 3 years
16 results on '"Doloy A"'

2. Novel scores relevant to antimicrobial resistance and hospital-acquired infections developed with data from a multi-hospital consortium in the Parisian region of France

Author

Lefevre, Laurence Armand, Aubry, Alexandra, Avettand-Fenoel, Véronique, Barbut, Frédéric, Belec, Laurent, Bercot, Béatrice, Bonacorsi, Stéphane, Calvez, Vincent, Cambau, Emmanuelle, Carbonnelle, Etienne, Charpentier, Charlotte, Chevaliez, Stéphane, Decousser, Jean-Winoc, Delaugerre, Constance, Descamps, Diane, Dortet, Laurent, Doucet-Populaire, Florence, Frange, Pierre, Fourati, Slim, Gaillard, Jean-Louis, Gault, Elyanne, Herrmann, Jean-Louis, Jarlier, Vincent, Kerneis, Solen, Le Goff, Jérôme, Mainardi, Jean-Luc, Marcelin, Anne-Geneviève, Morand-Joubert, Laurence, Pawlotsky, Jean-Michel, Poyart, Claire, Rameix-Welti, Marie-Anne, Robert, Jérôme, Rodriguez, Christophe, Roque Afonso, Anne-Marie, Rottman, Martin, Rozenberg, Flore, Ruppé, Etienne, Skurnik, David, Veziris, Nicolas, Zahar, Jean-Ralph, Barnaud, Guilene, Billard-Pomares, Typhaine, Cuzon, Gaëlle, Decré, Dominique, Doloy, Alexandra, Donay, Jean-Luc, Drieux-Rouzet, Laurence, Durand, Isabelle, Ferroni, Agnès, Fihman, Vincent, Fortineau, Nicolas, Gomart, Camille, Grall, Nathalie, Guillet-Caruba, Christelle, Jaureguy, Françoise, Lalande, Valérie, Landraud, Luce, Leflon, Véronique, Mariani, Patricia, Mihaila, Liliana, Moissenet, Didier, Noussair, Latifa, Podglajen, Isabelle, Poilane, Isabelle, Poupet, Hélène, Rondinaud, Emilie, Tardy, Valérie Sivadon, Trystram, David, Verdet, Charlotte, Vigier, Emmanuelle, Vimont-Billarant, Sophie, Amarsy, R., Granger, B., Fournier, S., Monteil, C., Trystram, D., Siorat, V., Jarlier, V., and Robert, J.

Published
2024
Full Text
View/download PDF

3. Surging bloodstream infections and antimicrobial resistance during the first wave of COVID–19: a study in a large multihospital institution in the Paris region

Author

Arlet, Guillaume, Lefevre, Laurence Armand, Aubry, Alexandra, Belec, Laurent, Bercot, Béatrice, Bonacorsi, Stéphane, Calvez, Vincent, Cambau, Emmanuelle, Carbonnelle, Etienne, Chevaliez, Stéphane, Decousser, Jean-Winoc, Delaugerre, Constance, Descamps, Diane, Doucet-Populaire, Florence, Gaillard, Jean-Louis, Chenon, Antoine Garbarg, Gault, Elyanne, Herrmann, Jean-Louis, Jarlier, Vincent, Goff, Jérôme Le, Lucet, Jean-Christophe, Mainardi, Jean-Luc, Marcellin, Anne-Geneviève, Morand-Joubert, Laurence, Nassif, Xavier, Pawlotsky, Jean-Michel, Robert, Jérôme, Afonso, Anne-Marie Roque, Rottman, Martin, Rouzioux, Christine, Rozenberg, Flore, Simon, François, Veziris, Nicolas, Skurnik, David, Zahar, Jean-Ralph, Barnaud, Guilene, Pomares, Typhaine Billard, Cuzon, Gaëlle, Decré, Dominique, Doloy, Alexandra, Donay, Jean-Luc, Drieux-Rouzet, Laurence, Durand, Isabelle, Ferroni, Agnès, Fihman, Vincent, Fortineau, Nicolas, Gomart, Camille, Grall, Nathalie, Caruba, Christelle Guillet, Jaureguy, Françoise, Lalande, Valérie, Landraud, Luce, Leflon, Véronique, Mariani, Patricia, Mihaila, Liliana, Moissenet, Didier, Noussair, Latifa, Podglajen, Isabelle, Poilane, Isabelle, Poupet, Hélène, Rondinaud, Emilie, Tardy, Valérie Sivadon, Trystram, David, Verdet, Charlotte, Vigier, Emmanuelle, Billarant, Sophie Vimont, Amarsy, Rishma, Monteil, Catherine, Fournier, Sandra, Oliary, Juliette, Junot, Helga, Sabatier, Pierre, and Porcher, Raphaël

Published
2022
Full Text
View/download PDF

4. Surging bloodstream infections and antimicrobial resistance during the first wave of COVID–19: a study in a large multihospital institution in the Paris region

Author

Rishma Amarsy, David Trystram, Emmanuelle Cambau, Catherine Monteil, Sandra Fournier, Juliette Oliary, Helga Junot, Pierre Sabatier, Raphaël Porcher, Jérôme Robert, Vincent Jarlier, Guillaume Arlet, Laurence Armand Lefevre, Alexandra Aubry, Laurent Belec, Béatrice Bercot, Stéphane Bonacorsi, Vincent Calvez, Etienne Carbonnelle, Stéphane Chevaliez, Jean-Winoc Decousser, Constance Delaugerre, Diane Descamps, Florence Doucet-Populaire, Jean-Louis Gaillard, Antoine Garbarg- Chenon, Elyanne Gault, Jean-Louis Herrmann, Jérôme Le Goff, Jean-Christophe Lucet, Jean-Luc Mainardi, Anne-Geneviève Marcellin, Laurence Morand-Joubert, Xavier Nassif, Jean-Michel Pawlotsky, Anne-Marie Roque Afonso, Martin Rottman, Christine Rouzioux, Flore Rozenberg, François Simon, Nicolas Veziris, David Skurnik, Jean-Ralph Zahar, Guilene Barnaud, Typhaine Billard Pomares, Gaëlle Cuzon, Dominique Decré, Alexandra Doloy, Jean-Luc Donay, Laurence Drieux-Rouzet, Isabelle Durand, Agnès Ferroni, Vincent Fihman, Nicolas Fortineau, Camille Gomart, Nathalie Grall, Christelle Guillet Caruba, Françoise Jaureguy, Valérie Lalande, Luce Landraud, Véronique Leflon, Patricia Mariani, Liliana Mihaila, Didier Moissenet, Latifa Noussair, Isabelle Podglajen, Isabelle Poilane, Hélène Poupet, Emilie Rondinaud, Valérie Sivadon Tardy, Charlotte Verdet, Emmanuelle Vigier, and Sophie Vimont Billarant

Subjects
COVID-19, Blood culture, Bloodstream infection incidence, Antibiotic consumption, Antimicrobial resistance, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: This study measured the impact of the first wave of COVID-19 pandemic (COVID-19) (March–April 2020) on the incidence of bloodstream infections (BSIs) at Assistance Publique – Hôpitaux de Paris (APHP), the largest multisite public healthcare institution in France. Methods: The number of patient admission blood cultures (BCs) collected, number of positive BCs, and antibiotic resistance and consumption were analysed retrospectively for the first quarter of 2020, and also for the first quarter of 2019 for comparison, in 25 APHP hospitals (ca. 14 000 beds). Results: Up to a fourth of patients admitted in March–April 2020 in these hospitals had COVID-19. The BSI rate per 100 admissions increased overall by 24% in March 2020 and 115% in April 2020, and separately for the major pathogens (Escherichia coli, Klebsiella pneumoniae, enterococci, Staphylococcus aureus, Pseudomonas aeruginosa, yeasts). A sharp increase in the rate of BSIs caused by microorganisms resistant to third-generation cephalosporins (3GC) was also observed in March–April 2020, particularly in K. pneumoniae, enterobacterial species naturally producing inducible AmpC (Enterobacter cloacae...), and P. aeruginosa. A concomitant increase in 3GC consumption occurred. Conclusions: The COVID-19 pandemic had a strong impact on hospital management and also unfavourable effects on severe infections, antimicrobial resistance, and laboratory work diagnostics.

Published
2022
Full Text
View/download PDF

5. High-level expression of chromosomally encoded SHV-1 β-lactamase reduces the susceptibility to cefiderocol of clinical isolates of Klebsiella pneumoniae

Author

Charfi, Rym, primary, Tazi, Asmaa, additional, Sereme, Youssouf, additional, Plainvert, Céline, additional, Poupet, Hélène, additional, Doloy, Alexandra, additional, Guyonnet, Cécile, additional, Morand, Philippe, additional, Loubinoux, Julien, additional, Poyart, Claire, additional, and Mammeri, Hedi, additional

Published
2024
Full Text
View/download PDF

6. Panggilan Berwirausaha Berdasarkan Kejadian 1:27-30

Author

Nesrian Pakudek, Agrilivita Doloy, Femy Carolina, Meys Elvelin Ponganan, Delpianti Batolu, and Klisti Aturut

Abstract

Berdasarkan Firman Tuhan dalam Kej 1:27-30, manusia diciptakan dan diberi mandat untuk mengusahakan kehidupan. Allah menciptakan segala sesuatu dan memberikan kepada manusia agar manusia bisa hidup. Dalam pengertian yang demikian maka sejak awal manusia sebenarnya dipanggil untuk berwirausaha. Berwirausaha adalah suatu panggilan karena beberapa alasan, yang pertama karena Allah sendiri dalam hal menjadikan alam semesta beserta isinya itu Ia sedang melakukan peran sebagai seorang wirausahawan, demikian juga pastinya Allah menghendaki itu diwarisi oleh manusia yang dicipta menurut gambaran-Nya. Alasan yang kedua yaitu melalui berwirausaha yang baik juga menumbuhkan relasi yang baik antar sesama manusia terlebih dengan pencipta, karena manusia dimandatkan untuk berkuasa dan mengelola bumi. Ketiga, karena dengan ketersediaanya segala sesuatu Sumber Daya Alam yang diciptakan Allah ini juga mendorong manusia disamping menjaga namun juga mengusahakannya dengan inovatif dan kreatif dan diarahkan pada Allah.

Published
2023
Full Text
View/download PDF

10. Frameshift mutation (690delG) in cpxA contributes to the extensive drug resistance of a Serratia marcescens clinical isolate

Author

Victor Gravrand, Frédéric Ariey, Laura Terracol, Hélène Poupet, Alexandra Doloy, Claire Poyart, and Hedi Mammeri

Subjects
Pharmacology, Microbiology (medical), Aminoglycosides, Infectious Diseases, Ciprofloxacin, Drug Resistance, Humans, Pharmacology (medical), Frameshift Mutation, Serratia marcescens, Anti-Bacterial Agents
Abstract

Objectives To identify the genetic change responsible for resistance to penicillins, extended-spectrum cephalosporins (ESCs), aminoglycosides and ciprofloxacin in a Serratia marcescens clinical isolate recovered from a pancreatic abscess 6 weeks after a WT strain was isolated from the same patient. The impact on the fitness was also assessed. Methods The genomes of both S. marcescens isolates were sequenced using Illumina technology, assembled, annotated and compared with each other. PCR amplification followed by Sanger sequencing was carried out to confirm the mutation. Complementation of the resistant isolate with a recombinant plasmid harbouring the WT gene was performed. The growth rates were measured for both isolates in LB medium. Results Comparative genomic analysis disclosed only one frameshift mutation (690delG) in the cpxA gene, which codes for the histidine kinase of a two-component system (TCS). This change introduced a premature termination codon, leading to the truncated CpxA_HatR variant that contained 234 amino acids instead of 464. Complementation, which consisted of transfer of the WT cpxA into the resistant S. marcescens derivative, restored completely its susceptibility to ESCs, aminoglycosides and ciprofloxacin, thus confirming the contribution of the CpxA_HatR variant to resistance. Growth analysis showed that the fitness of the resistant isolate was unchanged. Conclusions This study shows for the first time that constitutive activation of the Cpx pathway can per se confer resistance to ESCs and ciprofloxacin, in addition to the aminoglycoside resistance usually described. It sheds new light on the role of altered TCSs in fostering bacterial survival.

Published
2022
Full Text
View/download PDF

11. Decrease of hospital- and community-acquired bloodstream infections due to Streptococcus pneumoniae and Streptococcus pyogenes during the first year of the COVID-19 pandemic: A time-series analysis in Paris region

Author

Arlet, Guillaume, Lefevre, LaurenceArmand, Aubry, Alexandra, Belec, Laurent, Bercot, Béatrice, Bonacorsi, Stéphane, Calvez, Vincent, Cambau, Emmanuelle, Carbonnelle, Etienne, Chevaliez, Stéphane, Decousser, Jean-Winoc, Delaugerre, Constance, Descamps, Diane, Doucet-Populaire, Florence, Gaillard, Jean-Louis, Garbarg-Chenon, Antoine, Gault, Elyanne, Herrmann, Jean-Louis, Jarlier, Vincent, Le Goff, Jérôme, Lucet, Jean-Christophe, Mainardi, Jean-Luc, Marcellin, Anne-Geneviève, Morand-Joubert, Laurence, Nassif, Xavier, Pawlotsky, Jean-Michel, Robert, Jérôme, Afonso, Anne-Marie Roque, Rottman, Martin, Rouzioux, Christine, Rozenberg, Flore, Simon, François, Veziris, Nicolas, Skurnik, David, Zahar, Jean-Ralph, Barnaud, Guilene, Pomares, Typhaine Billard, Cuzon, Gaëlle, Decré, Dominique, Doloy, Alexandra, Donay, Jean-Luc, Drieux-Rouzet, Laurence, Durand, Isabelle, Ferroni, Agnès, Fihman, Vincent, Fortineau, Nicolas, Gomart, Camille, Grall, Nathalie, Caruba, Christelle Guillet, Jaureguy, Françoise, Lalande, Valérie, Landraud, Luce, Leflon, Véronique, Mariani, Patricia, Mihaila, Liliana, Moissenet, Didier, Noussair, Latifa, Podglajen, Isabelle, Poilane, Isabelle, Poupet, Hélène, Rondinaud, Emilie, Tardy, Valérie Sivadon, Trystram, David, Verdet, Charlotte, Vigier, Emmanuelle, Billarant, Sophie Vimont, Amarsy, Rishma, Fournier, Sandra, Monteil, Catherine, and Raynaud, Xavier

Published
2023
Full Text
View/download PDF

12. Decrease of hospital- and community-acquired bloodstream infections due to Streptococcus pneumoniae and Streptococcus pyogenes during the first year of the COVID-19 pandemic: A time-series analysis in Paris region

Author

Amarsy, Rishma, primary, Fournier, Sandra, additional, Trystram, David, additional, Monteil, Catherine, additional, Raynaud, Xavier, additional, Jarlier, Vincent, additional, Robert, Jérôme, additional, Arlet, Guillaume, additional, Lefevre, LaurenceArmand, additional, Aubry, Alexandra, additional, Belec, Laurent, additional, Bercot, Béatrice, additional, Bonacorsi, Stéphane, additional, Calvez, Vincent, additional, Cambau, Emmanuelle, additional, Carbonnelle, Etienne, additional, Chevaliez, Stéphane, additional, Decousser, Jean-Winoc, additional, Delaugerre, Constance, additional, Descamps, Diane, additional, Doucet-Populaire, Florence, additional, Gaillard, Jean-Louis, additional, Garbarg-Chenon, Antoine, additional, Gault, Elyanne, additional, Herrmann, Jean-Louis, additional, Le Goff, Jérôme, additional, Lucet, Jean-Christophe, additional, Mainardi, Jean-Luc, additional, Marcellin, Anne-Geneviève, additional, Morand-Joubert, Laurence, additional, Nassif, Xavier, additional, Pawlotsky, Jean-Michel, additional, Afonso, Anne-Marie Roque, additional, Rottman, Martin, additional, Rouzioux, Christine, additional, Rozenberg, Flore, additional, Simon, François, additional, Veziris, Nicolas, additional, Skurnik, David, additional, Zahar, Jean-Ralph, additional, Barnaud, Guilene, additional, Pomares, Typhaine Billard, additional, Cuzon, Gaëlle, additional, Decré, Dominique, additional, Doloy, Alexandra, additional, Donay, Jean-Luc, additional, Drieux-Rouzet, Laurence, additional, Durand, Isabelle, additional, Ferroni, Agnès, additional, Fihman, Vincent, additional, Fortineau, Nicolas, additional, Gomart, Camille, additional, Grall, Nathalie, additional, Caruba, Christelle Guillet, additional, Jaureguy, Françoise, additional, Lalande, Valérie, additional, Landraud, Luce, additional, Leflon, Véronique, additional, Mariani, Patricia, additional, Mihaila, Liliana, additional, Moissenet, Didier, additional, Noussair, Latifa, additional, Podglajen, Isabelle, additional, Poilane, Isabelle, additional, Poupet, Hélène, additional, Rondinaud, Emilie, additional, Tardy, Valérie Sivadon, additional, Verdet, Charlotte, additional, Vigier, Emmanuelle, additional, and Billarant, Sophie Vimont, additional

Published
2022
Full Text
View/download PDF

15. Surging bloodstream infections and antimicrobial resistance during the first wave of COVID–19: a study in a large multihospital institution in the Paris region

Author

Amarsy, Rishma, primary, Trystram, David, additional, Cambau, Emmanuelle, additional, Monteil, Catherine, additional, Fournier, Sandra, additional, Oliary, Juliette, additional, Junot, Helga, additional, Sabatier, Pierre, additional, Porcher, Raphaël, additional, Robert, Jérôme, additional, Jarlier, Vincent, additional, Arlet, Guillaume, additional, Lefevre, Laurence Armand, additional, Aubry, Alexandra, additional, Belec, Laurent, additional, Bercot, Béatrice, additional, Bonacorsi, Stéphane, additional, Calvez, Vincent, additional, Carbonnelle, Etienne, additional, Chevaliez, Stéphane, additional, Decousser, Jean-Winoc, additional, Delaugerre, Constance, additional, Descamps, Diane, additional, Doucet-Populaire, Florence, additional, Gaillard, Jean-Louis, additional, Chenon, Antoine Garbarg-, additional, Gault, Elyanne, additional, Herrmann, Jean-Louis, additional, Goff, Jérôme Le, additional, Lucet, Jean-Christophe, additional, Mainardi, Jean-Luc, additional, Marcellin, Anne-Geneviève, additional, Morand-Joubert, Laurence, additional, Nassif, Xavier, additional, Pawlotsky, Jean-Michel, additional, Afonso, Anne-Marie Roque, additional, Rottman, Martin, additional, Rouzioux, Christine, additional, Rozenberg, Flore, additional, Simon, François, additional, Veziris, Nicolas, additional, Skurnik, David, additional, Zahar, Jean-Ralph, additional, Barnaud, Guilene, additional, Pomares, Typhaine Billard, additional, Cuzon, Gaëlle, additional, Decré, Dominique, additional, Doloy, Alexandra, additional, Donay, Jean-Luc, additional, Drieux-Rouzet, Laurence, additional, Durand, Isabelle, additional, Ferroni, Agnès, additional, Fihman, Vincent, additional, Fortineau, Nicolas, additional, Gomart, Camille, additional, Grall, Nathalie, additional, Caruba, Christelle Guillet, additional, Jaureguy, Françoise, additional, Lalande, Valérie, additional, Landraud, Luce, additional, Leflon, Véronique, additional, Mariani, Patricia, additional, Mihaila, Liliana, additional, Moissenet, Didier, additional, Noussair, Latifa, additional, Podglajen, Isabelle, additional, Poilane, Isabelle, additional, Poupet, Hélène, additional, Rondinaud, Emilie, additional, Tardy, Valérie Sivadon, additional, Verdet, Charlotte, additional, Vigier, Emmanuelle, additional, and Billarant, Sophie Vimont, additional

Published
2022
Full Text
View/download PDF

16. Frameshift mutation (690delG) in cpxA contributes to the extensive drug resistance of a Serratia marcescens clinical isolate.

Author

Gravrand, Victor, Ariey, Frédéric, Terracol, Laura, Poupet, Hélène, Doloy, Alexandra, Poyart, Claire, and Mammeri, Hedi

Subjects
GENETIC mutation, CIPROFLOXACIN, DRUG resistance, AMINOGLYCOSIDES, SERRATIA, ANTIBIOTICS, PHARMACODYNAMICS
Abstract

Objectives: To identify the genetic change responsible for resistance to penicillins, extended-spectrum cephalosporins (ESCs), aminoglycosides and ciprofloxacin in a Serratia marcescens clinical isolate recovered from a pancreatic abscess 6 weeks after a WT strain was isolated from the same patient. The impact on the fitness was also assessed.Methods: The genomes of both S. marcescens isolates were sequenced using Illumina technology, assembled, annotated and compared with each other. PCR amplification followed by Sanger sequencing was carried out to confirm the mutation. Complementation of the resistant isolate with a recombinant plasmid harbouring the WT gene was performed. The growth rates were measured for both isolates in LB medium.Results: Comparative genomic analysis disclosed only one frameshift mutation (690delG) in the cpxA gene, which codes for the histidine kinase of a two-component system (TCS). This change introduced a premature termination codon, leading to the truncated CpxA_HatR variant that contained 234 amino acids instead of 464. Complementation, which consisted of transfer of the WT cpxA into the resistant S. marcescens derivative, restored completely its susceptibility to ESCs, aminoglycosides and ciprofloxacin, thus confirming the contribution of the CpxA_HatR variant to resistance. Growth analysis showed that the fitness of the resistant isolate was unchanged.Conclusions: This study shows for the first time that constitutive activation of the Cpx pathway can per se confer resistance to ESCs and ciprofloxacin, in addition to the aminoglycoside resistance usually described. It sheds new light on the role of altered TCSs in fostering bacterial survival. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results