Search

Abstract Background Trabectedin in combination with pegylated liposomal doxorubicin (PLD) is approved for the treatment of patients with platinum-sensitive relapsed ovarian cancer. Nevertheless, there is currently limited information regarding this treatment in elderly patients with ovarian cancer in a real-world setting. Methods This observational and multicentric study retrospectively evaluated trabectedin plus PLD in a real-world setting treatment of elderly patients diagnosed with platinum-sensitive relapsed ovarian cancer, treated according to the Summary of Product Characteristics (SmPC) from 15 GEICO-associated hospitals. Patients ≥ 70 years old at the time of treatment initiation and platinum-free intervals ≥ 6 months were considered eligible. Results Forty-three patients with a median age of 74.0 years were treated between January 1st, 2015, and December 31st, 2019 in 15 Spanish centers. Four patients achieved complete response (9.3%), 14 (32.6%) partial response, and 13 (30.2%) stable disease as the best radiological response. In the analysis of biological overall response according to CA125 serum levels (i.e., Rustin criteria), 14 responded to the treatment (32.6%), 11 responded and normalized (25.6%), three patients stabilized (7.0%) and three progressed (7.0%). Median progression-free survival (PFS) and overall survival (OS) in the study population were 7.7 and 19.5 months, respectively. The most common grade 3/4 adverse events were neutropenia (n = 8, 18.7%) and asthenia (n = 5, 11.6%). Conclusions This analysis demonstrated that trabectedin combined with PLD is a feasible and effective treatment in elderly patients with platinum-sensitive relapsed ovarian cancer, showing an acceptable safety profile, which is crucial in the palliative treatment of these patients.

The present study aims to determine the mediating effect that authentic coach leadership has on the interaction between coach competence and athletes' perceived support for basic psychological needs (BPN). A cross-sectional study was conducted with 115 team sports players (17.96 ±2.85 years of age; 8.18 ±4.67 years of experience) using the Basic Psychological Needs Support, Perceived Authentic Leadership, and Athletes' Perceptions of Coach Competence questionnaires. Correlation and mediation analyses (Coach Competence → Authentic Leadership → BPN Support) were performed. The results show a positive and significant indirect effect (ƥ = 0.288; 95% CI = 0.167, 0.415) of authentic leadership on the direct interaction between coach competence and BPN support (ƥ = 0.277; p < 0.01), increasing the total model effect (ƥ = 0.555; p < 0.01) to aid athletes' perceived BPN support when their coaches are competent and authentic leaders. In conclusion, it is not enough to be a well-prepared coach, he/she must also have the ability to lead, motivate and make decisions taking care of his/her interrelationships with athletes and promoting the satisfaction of basic psychological needs.

Abstract Background Self‐medication is a fairly common practice among medical doctors. Although frequently seen in clinical practice, there are few published studies that describe the process of self‐treatment in dermatology, being even lower in number those that evaluate this circumstance among health professionals. Objectives To know the prevalence of self‐medication among medical professionals in our centre, to assess the need for preventive and training actions that help to avoid the misuse of dermatological treatments. Methods Descriptive cross‐sectional study based on the responses of non‐dermatologist medical professionals at the University Hospital of Pontevedra (Spain). Data were collected through a self‐administered, anonymous and voluntary online questionnaire. Results The questionnaire was completed by 283 physicians (50.63% participation rate, 62.90% females). Up to 77.39% of the physicians carried out self‐treatment for any pathology, and 55.12% for dermatological problems. The mean age of the doctors who practiced self‐treatment was significantly higher. The most used drugs were corticosteroids as topical treatment and antihistamines as systemic therapy. Irritant or allergic contact dermatitis was the most frequent pathology considered suitable for self‐medication (18.02%), followed by fungal infections (16.86%). After self‐treatment, the 7.5% needed to be seen by a dermatologist. A large group of 69.23% stated that they would recommend the treatment carried out to someone suffering from a similar process. Conclusions The prevalence of self‐treatment for skin diseases among doctors was strikingly high (55.12%). More than two‐thirds of the surveyed physicians would recommend self‐treatment in the dermatology field. As the literature on this topic is yet scarce, further studies are required to corroborate data collected in this study.

Background: Open reduction and internal fixation with plate is one of the most widely used treatments for distal third humeral shaft fractures. The purpose of this study was to report the outcomes of the treatment of distal third humeral shaft fractures with posterior minimally invasive plate osteosynthesis (MIPO) with segmental isolation of the radial nerve. Methods: We performed an observational, retrospective, consecutive, monocentric, continuous multioperator study. We reviewed 22 distal third humeral shaft fractures treated with posterior MIPO in our institution with an extra-articular distal humerus plate from 2018 to 2021. Inclusion was limited to functionally independent patients with displaced fractures involving the junction of the middle and distal thirds of the humerus and minimum 12-month follow-up for implant removal. We assessed clinical outcomes including range of motion; QuickDASH score; Mayo Elbow Performance Score; and Constant-Murley score. Results: The average follow-up period of the sample was 31.7 ± 11.6 months (range, 15.7-51.3 months). The average elbow flexion and extension were 146.4° ± 7.3° (range, 120°-150°) and −0.7° ± 3.3° (range, −15° to 0°), respectively. The average shoulder anterior flexion, elevation, and abduction were 178.6° ± 3.6° (range, 170°-180°), 179.1° ± 2.9° (range, 170°-180°), and 140.9° ± 14.8° (range, 110°-160°), respectively. The average external rotation was 88.6° ± 6.4 (range, 65°-90°). The mean visual analog scale score for pain was 1.0 ± 1.6 (range, 0-5) and the mean Mayo Elbow Performance Score was 90.5 ± 9.9 (range, 70-100). The mean QuickDASH and Constant–Murley scores were 4.7 ± 6.8 (range, 0-20.5) and 95.5 ± 5.1 (range, 81-100), respectively. Two patients presented with relevant compromise of radial nerve motor function postoperatively (M3 and M2; the more compromised was preoperative injury). All patients recovered radial nerve neuropraxia within six weeks postoperatively. All fractures achieved union. The average anteroposterior and lateral axis were 175.0 ± 3.6 (168.0°-180.0°) and 177.5 ± 2.0 (173.0°-180.0°), respectively. No superficial or deep infection was reported. No cases of re-displacement of fracture, implant failure, or any other implant-related complication in follow-up were reported. No patient required plate withdrawal. Conclusion: The results of this study demonstrate that the posterior MIPO technique is a reliable option for treating distal third shaft humeral fractures. The radial nerve must be identified and protected in all cases to prevent palsy.

Abstract Pityriasis rubra pilaris (PRP) can be triggered by viruses, such as cytomegalovirus, Epstein‐Barr virus, varicella zoster, human immunodeficiency virus and, more exceptionally, SARS‐CoV‐2. We report an additional case of PRP following COVID‐19 infection. Given the existing literature and the close temporal association, we suggest a possible causal relationship. We speculate that an altered immune response with a genetic predisposition for PRP may have played a role in our patient. We highlight the development of PRP as part of the spectrum of COVID‐19 skin‐related conditions.

This review article focuses on agrivoltaic production systems (AV). The transition towards renewable energy sources, driven by the need to respond to climate change, competition for land use, and the scarcity of fossil fuels, has led to the consideration of new ways to optimise land use while producing clean energy. AV systems not only generate energy but also allow agricultural and livestock yields to be maintained or even increased under PV structures, offering a sustainable production strategy that may be more acceptable to local communities than traditional PV installations. This review assesses the technical feasibility of AV systems, the environmental, economic and social benefits, as well as the challenges faced and the legal framework regulating their implementation. It is highlighted that despite the advantages in land use efficiency and dual food and energy production, there are important challenges related to the initial investment required, the need for technological adaptation, social and regulatory obstacles, or the effects of shading on production. This paper underlines the importance of further research and development of these systems to overcome technical and economic constraints and maximise their potential benefits. It is concluded that although they present significant challenges, AV management offers promising opportunities to improve land efficiency and contribute to several sustainable development goals.

Breast cancer (BRCA) remains a significant global health challenge due to its prevalence and lethality, exacerbated by the development of resistance to conventional therapies. Therefore, understanding the molecular mechanisms underpinning chemoresistance is crucial for improving therapeutic outcomes. Human deoxycytidine triphosphate pyrophosphatase 1 (DCTPP1) has emerged as a key player in various cancers, including BRCA. DCTPP1, involved in nucleotide metabolism and maintenance of genomic stability, has been linked to cancer cell proliferation, survival, and drug resistance. This study evaluates the role of DCTPP1 in BRCA prognosis and chemotherapy response. Data from the Cancer Genome Atlas Program (TCGA), Genotype-Tissue Expression (GTEx), and Gene Expression Omnibus (GEO) repositories, analyzed using GEPIA and Kaplan–Meier Plotter, indicate that high DCTPP1 expression correlates with poorer overall survival and increased resistance to chemotherapy in BRCA patients. Further analysis reveals that DCTPP1 gene expression is up-regulated in non-responders to chemotherapy, particularly in estrogen receptor (ER)-positive, luminal A subtype patients, with significant predictive power. Additionally, in vitro studies show that DCTPP1 gene expression increases in response to 5-fluorouracil and doxorubicin treatments in luminal A BRCA cell lines, suggesting a hypothetical role in chemoresistance. These findings highlight DCTPP1 as a potential biomarker for predicting chemotherapy response and as a therapeutic target to enhance chemotherapy efficacy in BRCA patients.

El balonmano es algo más que ejecución. La percepción y la decisión le otorgan la condición de deporte complejo. Proponer entrenamientos en condiciones complejas y lo más parecidos a los partidos será una obligación del entrenador, así como diseñarlos bajo esas circunstancias. La concentración o atención ejecutiva permite a los jugadores focalizar de modo interno o externo su percepción. Un jugador en formación o uno experto no lo hacen de la misma manera. Es conveniente tener presente los dos modos de pensamiento: el sistema 1 o “sistema automático” y el sistema 2 o “sistema esforzado”. Asimismo, para el desarrollo de balonmanistas jóvenes, la dualidad entre “cantidad” y “calidad” de la información deberá estar presente. Además, la variabilidad y la impredecibilidad de las acciones aumentan la experiencia y facilitan la decisión. El error y el autocontrol completan, enriquecen y dinamizan el proceso de toma de decisión del jugador y son elementos que el entrenador debe regular. El trabajo finaliza con una propuesta para la construcción de ejercicios de entrenamiento, mostrando los elementos básicos en el diseño de tareas, con sus variantes temporales, espaciales y grupales y haciendo hincapié en las herramientas del autocontrol y del error.

El objetivo del presente estudio fue analizar los efectos en el salto y el lanzamiento tras aplicar un protocolo de autocargas y pliometría a un equipo universitario de balonmano femenino. Participaron 11 jugadoras amateur de balonmano (Medad = 23.70; DT = 2.26), que realizaron el protocolo de entrenamiento durante ocho semanas. Se estableció un diseño experimental a través del cual se realizaron evaluaciones pre y post intervención de lanzamiento de balón medicinal, velocidad de lanzamiento a portería, CMJ bipodal y unipodal, salto horizontal y asimetrías entre ambas piernas. Para la evaluación del efecto del entrenamiento se realizó una prueba t-test de muestras dependientes. Los resultados revelan que mejoraron en las pruebas de salto, pero no en las de lanzamiento. En conclusión, un protocolo de autocargas y pliometría es efectivo en el salto vertical.

Off-label prescription in paediatric patients is common, where some studies indicate that dermatological conditions are more prone to off-label treatment. This is the first study to analyse the prevalence of off-label prescription in paediatric dermatology consultation. This retrospective observational study was performed using the medical records of paediatric patients who were evaluated in a paediatric dermatological consultation in Pontevedra University Hospital, Pontevedra, Spain. Of the 468 patients reviewed, 186 prescriptions were issued and 51.10% were off-label prescription drugs. The dermatological conditions for which off-label prescription was most common were atopic dermatitis (29.0%), followed by warts (12.9%) and infantile haemangiomas (11.8%). With respect to drugs, topical tacrolimus (23.7%) was the most frequently prescribed off-label drug. The main reason for prescribing an off-label drug was for a disease not included on the label (62.4%), followed by issuing it at a lower age than authorized (55.9%). There was a significant association between a higher percentage of off-label prescription and younger age (p

This study aimed to assess the impact of the COVID-19 lockdown on healthy habits in a sample made up of Chilean international elite female handball players. Participants filled in an online survey regarding their physical activity levels, eating attitudes, sleep quality and psychological well-being, twice. The survey was sent within four weeks after mobility restrictions were imposed in Chile, and 16 weeks later, just after the easing of those restrictions began. A total of 18 female handball players who were competing in senior, junior or juvenile categories were analyzed. The obtained data indicated that physical activity levels decreased significantly, as well as psychological well-being. No significant changes were observed in the eating attitudes and sleep quality, although a significant reduction of sleep problems was detected. Sociodemographic and sport-related characteristics did not seem to produce a differential effect on the variables assessed.

Abstract Late osteosynthesis‐associated infection (OAI) is an uncommon and potentially serious disease. Its clinical presentation may mimic skin and soft tissue infection, leading to misdiagnosis. We report the case of a 64 year‐old man with a late OAI in the frontal bone, initially misdiagnosed as an infectious cellulitis. Late OAI can be difficult to suspect, especially if the intervention was performed years ago. Because of misdiagnosis, the symptoms can be masked by the use of antibiotics, so it is of utmost importance to take a detailed clinical history to make an early diagnosis and avoid potential complications. The treatment consists of the use of antibiotics and the replacement of the osteosynthesis material. Therefore, when facing a skin and soft tissue infection of torpid evolution which persists despite correct treatment and a past medical history of underlying osteosynthesis material, late OAI should be considered.

High rates of fertilizer applications potentially have significant environmental consequences, such as soil and water contamination and biodiversity loss. This study aimed to compare the use of biofertilizers and inorganic fertilizers in a broccoli crop to determine their impact on soil microorganism abundance, microbial community structure, functional gene diversity, yield, and greenhouse gas emissions. Four different fertilization treatments were designed: (i) inorganic fertilizers applied at a rate to cover the nutritional demands of the crop (F100); (ii) 50% of the rate of inorganic fertilizers added in F100 (F50); (iii) F50 + the application of a formulation of various bacteria (BA); and (iv) F50 + the application of a formulation of bacteria and non-mycorrhizal fungi (BA + FU). The results showed that reduced fertilization and the addition of both biofertilizer products had no significant effect on soil nutrients, microbial population, microbial activity, or yield when compared to conventional inorganic fertilization. Thus, microbial inoculants were ineffective in enhancing soil microbial abundance and activity, and there were no changes in GHG emissions or crop yields. Nonetheless, crop yield was positively related to total soil N, microbial activity, and CO2 emissions, confirming the positive effect of soil biodiversity on production. The application of biofertilizers can help reduce mineral fertilization in a broccoli crop with no negative effect on yield.

El catalizador de tres vías es una herramienta utilizada para reducir la emisión de gases contaminantes liberados por el motor de combustión interna de un automóvil. Este trabajo tiene como objetivo proporcionar una comprensión del funcionamiento e importancia de los catalizadores de tres vías. Se presenta una descripción general de la evolución histórica de su desarrollo, hasta llegar a la formulación y estructura de los catalizadores actuales. Además, se describe su funcionamiento a nivel molecular y las condiciones de operación que aseguran su eficiencia de conversión. Discutimos las ventajas al medio ambiente y a la salud humana que acompañan su uso adecuado. Por último, se remarca la importancia de su reemplazo oportuno.

RESUMEN: En este artículo se aborda la relación entre comunidad y enemistad en la teología de Dietrich Bonhoeffer. Particularmente, este artículo se enfoca en los textos del período 1937-1940 donde la noción de enemigo ha sido ampliamente desarrollada por el teólogo luterano. En adelante se discutirá cómo al interior de la teología de Bonhoeffer las nociones amigo, hermano y enemigo tienen un lugar diferenciado pero constitutivo de ambas comunidad y cristianismo. Un propósito vinculado con este trabajo consiste en determinar la continuidad o ruptura del pensamiento de Bonhoeffer con tradiciones filosóficas o teológicas que han ubicado los términos amigo, hermano y enemigo como criterios de discriminación en torno a los vivientes que propician o amenazan una vida común. PALABRAS CLAVE: Bonhoeffer. Enemigo. Comunidad. Teología. Política.

En la iniciación al balonmano intervienen elementos que buscan capacitar psicomotrizmente a todos los niños participantes para resolver diferentes tareas que presenta el juego. Para ello, la competición es un espacio donde los jugadores pueden poner en práctica los aprendizajes desarrollados. Sin embargo, en Latinoamérica, la estructura y el enfoque de la competencia no necesariamente permite que esto suceda. Desde esa perspectiva, el objetivo del presente estudio es el comprender como el enfoque pedagógico o la inexistencia de este respecto a la competencia impacta los procesos de aprendizaje de los niños iniciantes en balonmano en Latinoamérica. Se utilizó la investigación cualitativa con un diseño fenomenológico. Como criterios de inclusión se exigió que los participantes sean: a) profesores de educación física; b) que estén vinculados a las etapas de iniciación al Balonmano (de benjamín a mini); c) mínimo 5 años de experiencia trabajando en Latinoamérica. Como resultados se destaca el valor que tiene la competición para generar integración de aprendizajes en los jugadores y un acercamiento progresivo a las situaciones del juego. Por lo tanto, se concluye que toda acción formativa en la iniciación al deporte debe estar contextualizada como un espacio rico en aprendizajes, por lo que la competencia también lo debe ser.

IntroductionThe purpose of this investigation was to explore patients’ and oncologists’ preferences for the characteristics of a pharmacological regimen for patients with advanced renal cell carcinoma (aRCC).Material and MethodsCross-sectional observational study based on a discrete choice experiment (DCE) conducted in Spain. A literature review, a focus group with oncologists and interviews with patients informed the DCE design. Five attributes were included: progression survival gain, risk of serious adverse events (SAEs), health-related quality of life (HRQoL), administration mode, and treatment cost. Preferences were analyzed using a mixed-logit model to estimate relative importance (RI) of attributes (importance of an attribute in relation to all others), which was compared between aRCC patients and oncologists treating aRCC. Willingness to pay (WTP, payer: health system) for a benefit in survival or in risk reduction and maximum acceptable risk (MAR) in SAEs for improving survival were estimated from the DCE. Subgroup analyses were performed to identify factors that influence preference.ResultsA total of 105 patients with aRCC (77.1% male, mean age 65.9 years [SD: 10.4], mean time since RCC diagnosis 6.3 years [SD: 6.1]) and 67 oncologists (52.2% male, mean age 41.9 years [SD: 8.4], mean duration of experience in RCC 10.2 years [SD: 7.5]) participated in the study. The most important attribute for patients and oncologists was survival gain (RI: 43.6% vs. 54.7% respectively, p

Abstract is missing (Quiz)

The assessment of remediation on metal-polluted soils is usually focused on total and/or bioavailable metal content. However, these chemical variables do not provide direct information about reductions in heavy metals pressure on soil microorganisms. We propose the use of bacterial communities to evaluate the efficiency of three remediation techniques: crushed mussel shell (CMS) and pine bark (PB) as soil amendments and EDTA-washing. A soil sample was polluted with different doses of Cu, Ni, and Zn (separately). After 30 days of incubation, the remediation techniques were applied, and bacterial community tolerance to heavy metals determined. If bacterial communities develop tolerance, it is an indicator that the metal is exerting toxicity on them. Soil bacterial communities developed tolerance to Cu, Ni, and Zn in response to metal additions. After remediation, bacterial communities showed decreases in bacterial community tolerance to Cu, Ni, and Zn for all remediation techniques. For Cu and Ni, soil EDTA-washing showed the greatest reduction of bacterial community tolerance to Cu and Ni, respectively, while for Zn the soil amendment with PB was the most effective remediation technique. Thus, bacterial community tolerance to heavy metals successfully detect differences in the effectiveness of the three remediation techniques.

A Three-Way Catalyst (TWC) contains a cordierite ceramic monolith coated with a layer of Al2O3, CexZr1−xO2 and platinoids mixture. Under standard operation, the platinoid concentration decreases, exposing the remaining washcoat structure. After that particle release stage, the sintering process follows where the crystalline CexZr1−xO2 solution is broken and begins to separate into ZrO2 and CeO2 phases. ZrO2 is released to the environment as micro and nanoparticles, while a small amount of CeO2 generates a new AlxCe1−xO2 composite. The main effect of Ce capture is the growth in the size of the polycrystal structure from 86.13 ± 16.58 nm to 225.35 ± 69.51 nm. Moreover, a transformation of cordierite to mullite was identified by XRD analysis. Raman spectra showed that the oxygen vacancies (Vö) concentration decreased as CexZr1−xO2 phases separation occurred. The SEM-EDS revealed the incorporation of new spurious elements and microfractures favouring the detachment of the TWC support structure. The release of ultrafine particles is a consequence of catalytic devices overusing. The emission of refractory micro to nanocrystals to the atmosphere may represent an emerging public health issue underlining the importance of implementing strict worldwide regulations on regular TWCs replacement.

High rates of fertilizer applications potentially have significant environmental consequences, such as soil and water contamination and biodiversity loss. This study aimed to compare the use of biofertilizers and inorganic fertilizers in a broccoli crop to determine their impact on soil microorganism abundance, microbial community structure, functional gene diversity, yield, and greenhouse gas emissions. Four different fertilization treatments were designed: (i) inorganic fertilizers applied at a rate to cover the nutritional demands of the crop (F100); (ii) 50% of the rate of inorganic fertilizers added in F100 (F50); (iii) F50 + the application of a formulation of various bacteria (BA); and (iv) F50 + the application of a formulation of bacteria and non-mycorrhizal fungi (BA + FU). The results showed that reduced fertilization and the addition of both biofertilizer products had no significant effect on soil nutrients, microbial population, microbial activity, or yield when compared to conventional inorganic fertilization. Thus, microbial inoculants were ineffective in enhancing soil microbial abundance and activity, and there were no changes in GHG emissions or crop yields. Nonetheless, crop yield was positively related to total soil N, microbial activity, and CO2 emissions, confirming the positive effect of soil biodiversity on production. The application of biofertilizers can help reduce mineral fertilization in a broccoli crop with no negative effect on yield. [ABSTRACT FROM AUTHOR]