16 results on '"Delorme, Pierre"'
Search Results
2. Timing of antenatal corticosteroids and survival without neurologic disabilities at 5½ years in children born before 35 weeks of gestation
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Guerini, Claire, Goffinet, François, Marchand-Martin, Laetitia, Delorme, Pierre, Pierrat, Véronique, Ancel, Pierre-Yves, and Schmitz, Thomas
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- 2023
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3. Birth weight and head circumference discordance and outcome in preterms: results from the EPIPAGE-2 cohort.
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Guellec, Isabelle, Brunet, Adelaide, Lapillonne, Alexandre, Taine, Marion, Torchin, Héloïse, Favrais, Geraldine, Gascoin, Géraldine, Simon, Laure, Heude, Barbara, Scherdel, Pauline, Kayem, Gilles, Delorme, Pierre, Jarreau, Pierre-Henri, and Ancel, Pierre-Yves
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CHORIOAMNIONITIS ,BIRTH weight ,PHYSIOLOGY ,LOW birth weight ,FETAL growth retardation ,SMALL for gestational age - Published
- 2024
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4. Hélène Clastres (1936‑2023)
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Launay, Pauline, primary and Delorme, Pierre-Alexandre, additional
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- 2023
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5. Tocolysis after preterm prelabor rupture of membranes and 5-year outcomes: a population-based cohort study (EPIPAGE-2)
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LORTHERM, Elsa, primary, MARCHAND-MARTIN, Laetitia, additional, LETOUZEY, Mathilde, additional, AUBERT, Adrien M., additional, PIERRAT, Véronique, additional, BENHAMMOU, Valérie, additional, DELORME, Pierre, additional, MARRET, Stéphane, additional, ANCEL, Pierre-Yves, additional, GOFFINET, François, additional, L’HÉLIAS, Laurence Foix, additional, and KAYEM, Gilles, additional
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- 2023
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6. Chorionicity and neurodevelopmental outcomes at 5½ years among twins born preterm: the EPIPAGE2 cohort study.
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Hoarau, Delphine, Tosello, Barthélémy, Blanc, Julie, Lorthe, Elsa, Foix‐L'Helias, Laurence, D'Ercole, Claude, Winer, Norbert, Subtil, Damien, Goffinet, François, Kayem, Gilles, Resseguier, Noémie, Gire, Catherine, Ancel, Pierre‐Yves, Arnaud, Catherine, Arthuis, Chloé, Boileau, Pascal, Debillon, Thierry, Delorme, Pierre, Desplanches, Thomas, and Diguisto, Caroline
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FETOFETAL transfusion ,NEURAL development ,APRAXIA ,TWINS ,COHORT analysis ,CEREBRAL palsy - Abstract
Objective: To compare the neurodevelopmental outcomes of preterm twins at 5½ years by chorionicity of pregnancy. Design: Prospective nationwide population‐based EPIPAGE2 (Etude Epidémiologique sur les Petits Âges Gestationnels) cohort study. Setting: A total of 546 maternity units in France, between March and December 2011. Population: A total of 1126 twins eligible for follow‐up at 5½ years. Methods: The association of chorionicity with outcomes was analysed using multivariate regression models. Main outcome measures: Survival at 5½ years with or without neurodevelopmental disabilities (comprising cerebral palsy, visual, hearing, cognitive deficiency, behavioural difficulties or developmental coordination disorders) were described and compared by chorionicity. Results: Among the 1126 twins eligible for follow‐up at 5½ years, 926 (82.2%) could be evaluated: 228 monochorionic (MC) and 698 dichorionic (DC). Based on chronicity and gestational age of birth, we found no significant differences for severe neonatal morbidity. The rates of moderate/severe neurobehavioral disabilities were similar in infants from DC pregnancies versus infants from MC pregnancies (OR 1.22, 95% CI 0.65–2.28). By gestational age and without twin–twin transfusion syndrome (TTTS), no difference according to chorionicity was found for all neurodevelopmental outcome measures. Conclusions: The neurodevelopmental outcomes among preterm twins at 5½ years is similar, irrespective of chorionicity. Linked article: This article is commented on by R. N. Brown, pp. 1059 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17527. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial
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Bistervels, Ingrid M, primary, Buchmüller, Andrea, additional, Wiegers, Hanke M G, additional, Ní Áinle, Fionnuala, additional, Tardy, Bernard, additional, Donnelly, Jennifer, additional, Verhamme, Peter, additional, Jacobsen, Anne F, additional, Hansen, Anette T, additional, Rodger, Marc A, additional, DeSancho, Maria T, additional, Shmakov, Roman G, additional, van Es, Nick, additional, Prins, Martin H, additional, Chauleur, Céline, additional, Middeldorp, Saskia, additional, van den Akker, Eline S, additional, Bekker, Mireille N, additional, van Bemmel, Thomas, additional, Bertoletti, Laurent, additional, Blanc, Julie, additional, Bleker, Suzanne M, additional, Bourtembourg-Matras, Aude, additional, Bretelle, Florence, additional, Byrne, Bridgette, additional, Couturaud, Francis, additional, Delorme, Pierre, additional, Eerenberg, Elise S, additional, Franssen, Maureen TM, additional, Fuglsang, Jens, additional, Ganzevoort, Wessel, additional, Goffinet, François, additional, de Haan-Jebbink, Jiska M, additional, Heidema, Wieteke, additional, Hertzberg, Monique A, additional, Hovens, Marcel MC, additional, Huisman, Menno V, additional, de Jong-Speksnijder, Leonie, additional, Kamphuisen, Pieter-Willem, additional, O'Keeffe, Denis J, additional, Lacut, Karine, additional, Langenveld, Josje, additional, Lunshof, M Simone, additional, Martens, Caroline P, additional, Merah, Adel, additional, Le Moigne, Emmanuelle, additional, Papatsonis, Dimitri NM, additional, Pernod, Gilles, additional, Perrotin, Franck, additional, Peynaud-Debayle, Edith, additional, Pierre, Fabrice, additional, Plu Bureau, Geneviève, additional, Raia-Barjat, Tiphaine, additional, Rijnders, Robbert JP, additional, Rosario, Roger, additional, Ruivard, Marc, additional, Schmidt, Jeannot, additional, Sueters, Marieke, additional, Vanassche, Thomas, additional, Varlet, Marie-Noëlle, additional, Vivanti, Alexandre J, additional, van der Vlist, Matthieu Y, additional, van der Voet, Lucet F, additional, Vollebregt, Karlijn C, additional, de Vries, Johanna IP, additional, de Weerd, Sabina, additional, Westerweel, Peter E, additional, Wijnberger, Lia DE, additional, ten Wolde, Marije, additional, Ypma, Paula F, additional, Zuily-Lamy, Catherine, additional, Zwart, Joost J, additional, Benachi, Alexandra, additional, Beucher, Gaël, additional, Bezanahary, Holy, additional, de Boer, Karin, additional, de Boer, Marjon A., additional, Bousquet, Frantz, additional, Bremer, Henk A., additional, Bressollette, Luc, additional, Brossard, Aurélie, additional, Chau, Cécile, additional, Cleary, Brian, additional, Comte, Fabienne, additional, Corsini, Thomas, additional, Coustel, Anne, additional, Debaveye, Barbara, additional, Desbrière, Raoul, additional, Duvillard, Cécile, additional, Eckman, Astrid, additional, Eikenboom, Jeroen, additional, Elias, Antoine, additional, Faber, Laura M., additional, Ferrari, Emile, additional, Gallot, Denis, additional, Gauchotte, Emilie, additional, Gaugler, Ingrid, additional, Geerlings, Abby E., additional, O'Gorman, Audrey, additional, Grobost, Vincent, additional, de Groot, Pieter-Kees, additional, van der Ham, David P., additional, Hermsen, Brenda, additional, Kamphorst, Kim, additional, Karovitch, Alan, additional, Kleiverda, Gunilla, additional, Kloster, Aiste, additional, Koops, Annemarieke, additional, Krabbendam, Inneke, additional, Kruip, Marieke J.H.A., additional, Kuipers, Saskia, additional, van Laar, Judith, additional, Laneelle, Damien, additional, Lima, Suzanne, additional, MacMahon, Peter, additional, Mandelbrot, Laurent, additional, van Meir, Claudia A., additional, Menez, Caroline, additional, Morssink, Leonard P., additional, Moulin, Nathalie, additional, Mousty, Eve, additional, Muller, Matthieu, additional, Murphy, Lucy, additional, Peerlinck, Kathelijne, additional, O'Reilly, Alma, additional, de Reus, Maartje, additional, Le Roux, Magali Hilmi, additional, Ryan, Kevin, additional, Samren, Bettina, additional, Schippers, Daniela, additional, Schuitemaker, Nico, additional, Schweizer, Chloé, additional, van der Straaten, Hanneke, additional, Tromeur, Cécile, additional, Vanheule, Kristine, additional, Verhagen, Tamara, additional, Visser, Jantien, additional, Watts, Michael, additional, van Wijngaarden, Wim J., additional, Woiski, Mallory, additional, and Zelis, Maartje, additional
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- 2022
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8. Normativité et gouvernementalité néolibérales. Les formes de l’assujettissement par captation de l’agir transgressif
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Delorme, Pierre-Alexandre, primary
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- 2022
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9. Risk of preterm delivery after medically indicated termination of pregnancy with induced vaginal delivery: a case-control study
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Hini, Jean-Daniel, primary, Kayem, Gilles, additional, Quibel, Thibaud, additional, Berveiller, Paul, additional, De Carne Carnavale, Celine, additional, and Delorme, Pierre, additional
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- 2022
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10. Sentilhes L, Sénat M.V, Bouchghoul H, Delorme P, Gallot D, Garabedian C, Madar H, Sananès N, Perrotin F, Schmitz T. Réponse à l’article de Boujenah J. intitulé « La cholestase gravidique : pour une vision holistique de la femme. À propos des examens complémentaires lors du diagnostic ». Gynecol Obstet Fertil 2024;52(6). doi:10.1016/j.gofs.2024.02.023
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Sentilhes, Loïc, Sénat, Marie-Victoire, Bouchghoul, Hanane, Delorme, Pierre, Gallot, Denis, Garabedian, Charles, Madar, Hugo, Sananès, Nicolas, Perrotin, Franck, and Schmitz, Thomas
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- 2024
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11. Le carnaval ��tudiant : d���un carnaval universitaire ritualis�� �� un ��v��nement culturel de masse ?
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Delorme, Pierre-Alexandre
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s��curit�� ,pratique festive ,carnaval ,��tudiant ,universit�� ,culture - Abstract
Le carnaval ��tudiant de Caen existe depuis 1894 sous la forme de cavalcade ��tudiante. Il est interrompu en 1963 mais reprend en 1996 avec l���initiative d�����tudiants en arts du spectacle. La participation s���accro��t au fil des ann��es jusqu����� rassembler 30000 participants en 2017, devenant l���un des plus importants carnavals ��tudiant en France et un ��v��nement culturel majeur de la ville. D��s 2014, le trac�� du d��fil�� est enti��rement modifi�� et s�����loigne du centre-ville: une rupture g��ographique et historique qui t��moigne d���un changement d���ampleur et de nature de cette manifestation.
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- 2022
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12. Antibiotic prophylaxis in preterm premature rupture of membranes at 24–31 weeks’ gestation: Perinatal and 2‐year outcomes in the EPIPAGE‐2 cohort
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Lorthe, Elsa, Letouzey, Mathilde, Torchin, Héloïse, Foix L'Helias, Laurence, Gras‐le Guen, Christèle, Benhammou, Valérie, Boileau, Pascal, Charlier, Caroline, Kayem, Gilles, Ancel, Pierre‐yves, Arnaud, Catherine, Blanc, Julie, Debillon, Thierry, Delorme, Pierre, D’ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Gascoin, Géraldine, Gire, Catherine, Goffinet, François, Langer, Bruno, Maisonneuve, Emeline, Marret, Stéphane, Monier, Isabelle, Morgan, Andrei, Rozé, Jean‐christophe, Schmitz, Thomas, Sentilhes, Loïc, Subtil, Damien, Tosello, Barthélémy, Vayssière, Christophe, Winer, Norbert, Zeitlin, Jennifer, Astruc, D, Kuhn, P, Matis, J, Ramousset, C, Hernandorena, X, Chabanier, P, Joly‐pedespan, L, Costedoat, Mj, Leguen, A, Lecomte, B, Lemery, D, Vendittelli, F, Beucher, G, Dreyfus, M, Guillois, B, Toure, Y, Burguet, A, Couvreur, S, Gouyon, Jb, Sagot, P, Colas, N, Sizun, J, Beuchée, A, Pladys, P, Rouget, F, Dupuy, Rp, Soupre, D, Charlot, F, Roudaut, S, Favreau, A, Saliba, E, Reboul, L, Bednarek, N, Morville, P, Verrière, V, Thiriez, G, Balamou, C, Marpeau, L, Barbier, C, Durrmeyer, X, Granier, M, Ayoubi, M, Baud, O, Carbonne, B, Jarreau, Ph, Mitanchez, D, Duffaut, C, Cornu, L, Moras, R, Boulot, P, Cambonie, G, Daudé, H, Badessi, A, Tsaoussis, N, Bédu, A, Mons, F, Bahans, C, Binet, Mh, Fresson, J, Hascoët, Jm, Milton, A, Morel, O, Vieux, R, Hilpert, L, Alberge, C, Baron, M, Charkaluk, Ml, Pierrat, V, Truffert, P, Akowanou, S, Simeoni, U, Bongain, A, Deschamps, M, Branger, B, Rouger, V, Dupont, C, Gondry, Jean, Krim, G, Baby, B, Debeir, M, Claris, O, Picaud, Jc, Rubio‐gurung, S, Cans, C, Ego, A, Patural, H, Rannaud, A, Janky, E, Poulichet, A, Rosenthal, Jm, Coliné, E, Favre, A, Joly, N, Châlons, S, Pignol, J, Laurence, Pl, Robillard, Py, Samperiz, S, Ramful, D, Blondel, B, Bonet, M, Brinis, A, Coquelin, A, Durox, M, Kaminski, M, Khemache, K, Khoshnood, B, Lebeaux, C, Marchand‐martin, L, Rousseau, J, Saurel‐cubizolles, Mj, Tran, D, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier universitaire de Nantes (CHU Nantes), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris], Assistance Publique - Hôpitaux de Paris, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service Epidémiologie clinique et santé publique [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Unité de biostatistiques [Centre Georges-François Leclerc], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Médecine Néonatale et Réanimation Pédiatrique CHU Grenoble, CHU Grenoble, Service de gynécologie-obstétrique [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Service de Néonatologie, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Recherches épidémiologiques en santé périnatale et santé des femmes, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 (GRAMFC), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Funding information:This work was partly supported by a postdoctoral grant from the Fondation des Treilles to EL. EPIPAGE-2 was funded by the French Institute of Public Health Research (IRESP TGIR 2009-01 programme)/Institute of Public Health and its partners: the French Health Ministry, the National Institute of Health and Medical Research (INSERM), the National Institute of Cancer, and the National Solidarity Fund for Autonomy (CNSA), the National Research Agency through the French EQUIPEX programme of investments for the future (grant number ANR-11-EQPX-0038), and the PREMUP Foundation. Additional funding was obtained from Fondation pour la Recherche Medicale (grant number SPF 20160936356) and Fondation de France (grant numbers 00050329, Grand Prix R18202KK]). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript., ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Education, Formation, Travail, Savoirs (EFTS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Centre Hospitalier Universitaire [Grenoble] (CHU), Modélisation et Évaluation des données complexes en Santé Publique (TIMC-MESP), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Dijon, Hôpital Nord [CHU - APHM], Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Department of Obstetrics and Gynecology, Les Hôpitaux Universitaires de Strasbourg (HUS), EPIPAGE-2 Study Group, and Institut National de la Santé et de la Recherche Médicale (INSERM)
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Fetal Membranes, Premature Rupture ,obstetric intervention ,[SDV]Life Sciences [q-bio] ,Gestational Age ,antenatal management ,Cohort Studies ,Pregnancy ,Escherichia coli ,Humans ,Prospective Studies ,latency ,amoxicillin ,neurodevelopment ,macrolides ,prematurity ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,Infant ,prophylactic antibiotics ,Antibiotic Prophylaxis ,Anti-Bacterial Agents ,perinatal outcome ,cephalosporins ,Premature Birth ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Neonatal Sepsis ,Infant, Premature - Abstract
To compare different antibiotic prophylaxis administered after preterm premature rupture of membranes to determine whether any were associated with differences in obstetric and/or neonatal outcomes and/or neurodevelopmental outcomes at 2 years of corrected age.Prospective, nationwide, population-based EPIPAGE-2 cohort study of preterm infants.France, 2011.We included 492 women with a singleton pregnancy and a diagnosis of preterm premature rupture of membranes at 24-31 weeks. Exclusion criteria were contraindication to expectant management or indication for antibiotic therapy other than preterm premature rupture of membranes. Antibiotic prophylaxis was categorised as amoxicillin (n = 345), macrolide (n = 30), third-generation cephalosporin (n = 45) or any combinations covering Streptococcus agalactiae and90% of Escherichia coli (n = 72), initiated within 24 hours after preterm premature rupture of membranes.Population-averaged robust Poisson models.Survival at discharge without severe neonatal morbidity, 2-year neurodevelopment.With amoxicillin, macrolide, third-generation cephalosporin and combinations, 78.5%, 83.9%, 93.6% and 86.0% of neonates were discharged alive without severe morbidity. The administration of third-generation cephalosporin or any E. coli-targeting combinations was associated with improved survival without severe morbidity (adjusted risk ratio 1.25 [95% confidence interval 1.08-1.45] and 1.10 [95 % confidence interval 1.01-1.20], respectively) compared with amoxicillin. We evidenced no increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.In preterm premature rupture of membranes at 24-31 weeks, antibiotic prophylaxis based on third-generation cephalosporin may be associated with improved survival without severe neonatal morbidity when compared with amoxicillin, with no evidence of increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.Antibiotic prophylaxis after PPROM at 24-31 weeks: 3rd-generation cephalosporins associated with improved neonatal outcomes.
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- 2022
13. Preterm and term prelabour rupture of membranes: A review of timing and methods of labour induction
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Delorme, Pierre, primary, Lorthe, Elsa, additional, Sibiude, Jeanne, additional, and Kayem, Gilles, additional
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- 2021
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14. Tocolysis after preterm prelabor rupture of membranes and 5-year outcomes: a population-based cohort study.
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Lorthe, Elsa, Marchand-Martin, Laetitia, Letouzey, Mathilde, Aubert, Adrien M., Pierrat, Véronique, Benhammou, Valérie, Delorme, Pierre, Marret, Stéphane, Ancel, Pierre-Yves, Goffinet, François, L'Hélias, Laurence Foix, and Kayem, Gilles
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PREMATURE rupture of fetal membranes ,PREGNANT women ,NEONATAL death ,APRAXIA ,COHORT analysis - Abstract
The administration of tocolytics after preterm prelabor rupture of membranes remains a controversial practice. In theory, reducing uterine contractility should delay delivery and allow for optimal antenatal management, thereby reducing the risks for prematurity and adverse consequences over the life course. However, tocolysis may be associated with neonatal death or long-term adverse neurodevelopmental outcomes, mainly related to prolonged fetal exposure to intrauterine infection or inflammation. In a previous study, we showed that tocolysis administration was not associated with short-term benefits. There are currently no data available to evaluate the impact of tocolysis on neurodevelopmental outcomes in school-aged children born prematurely in this clinical setting. This study aimed to investigate whether tocolysis administered after preterm prelabor rupture of membranes is associated with neurodevelopmental outcomes at 5.5 years of age. We used data from a prospective, population-based cohort study of preterm births recruited in 2011 (referred to as the EPIPAGE-2 study) and for whom the results of a comprehensive medical and neurodevelopmental assessment of the infant at age 5.5 years were available. We included pregnant individuals with preterm prelabor rupture of membranes at 24 to 32 weeks' gestation in singleton pregnancies with a live fetus at the time of rupture, birth at 24 to 34 weeks' gestation, and participation of the infant in an assessment at 5.5 years of age. Exposure was the administration of any tocolytic treatment after preterm prelabor rupture of membranes. The main outcome was survival without moderate to severe neurodevelopmental disabilities at 5.5 years of age. Secondary outcomes included survival without any neurodevelopmental disabilities, cerebral palsy, full-scale intelligence quotient, developmental coordination disorders, and behavioral difficulties. A propensity-score analysis was used to minimize the indication bias in the estimation of the treatment effect on outcomes. Overall, 596 of 803 pregnant individuals (73.4%) received tocolytics after preterm prelabor rupture of membranes. At the 5.5-year follow-up, 82.7% and 82.5% of the children in the tocolysis and no tocolysis groups, respectively, were alive without moderate to severe neurodevelopmental disabilities; 52.7% and 51.1%, respectively, were alive without any neurodevelopmental disabilities. After applying multiple imputations and inverse probability of treatment weighting, we found no association between the exposure to tocolytics and survival without moderate to severe neurodevelopmental disabilities (odds ratio, 0.93; 95% confidence interval, 0.55–1.60), survival without any neurodevelopmental disabilities (odds ratio, 1.02; 95% confidence interval, 0.65–1.61), or any of the other outcomes. There was no difference in the neurodevelopmental outcomes at age 5.5 years among children with and without antenatal exposure to tocolysis after preterm prelabor rupture of membranes. To date, the health benefits of tocolytics remain unproven, both in the short- and long-term. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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15. Routine maneuvers in eutocic breech vaginal delivery at term: A prospective cohort study.
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Touleimat, Salma, Braund, Sophia, Delorme, Pierre, Diguet, Alain, Goffinet, François, Hennebert, Cécile, and Verspyck, Eric
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DELIVERY (Obstetrics) , *BREECH delivery , *LONGITUDINAL method , *POSTPARTUM hemorrhage , *COHORT analysis - Abstract
Objective Methods Results Conclusion To study neonatal and maternal outcomes associated with routine maneuvers in breech vaginal delivery at term.This was a secondary analysis of the multicenter PREMODA observational prospective study in France and Belgium. We included women with vaginal breech delivery, excluding those who underwent maneuvers to resolve a dystocic delivery. Maternal data and characteristics of labor, in addition to neonatal and maternal outcomes, were recorded. We defined two groups according to mode of delivery; breech vaginal delivery with or without routine maneuvers, and we compared the variables between the groups. To assess the factors associated with adverse perinatal outcomes, a multivariate logistic regression with adjustment for confounders was performed.Of the 2502 women with planned vaginal deliveries, 1794 were delivered vaginally, 606 of whom were excluded from the study due to maneuvers performed for dystocia. A total of 25 other patients were excluded as a result of missing data. A total of 537 women were included in the routine maneuvers group and 626 women in the no maneuvers group. Adverse perinatal outcome was similar for the two groups (4.5% vs 5.0%, P = 0.65) and no neonatal deaths were reported. Third degree perineal tear and postpartum hemorrhage >1 L rates were comparable for the two groups. After adjustment, the factors associated with adverse perinatal outcomes were primiparity and birth weight <2500 g.Routine maneuvers were not associated with an increase in neonatal morbidity in our population. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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16. [Normal pregnancy].
- Author
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Delorme P, Codaccioni C, and Azria É
- Abstract
Competing Interests: Les auteurs déclarent n’avoir aucun lien d’intérêts.
- Published
- 2024
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