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24 results on '"Deleage, Claire"'

1. Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence

Author

Strongin, Zachary, Raymond Marchand, Laurence, Deleage, Claire, Pampena, M. Betina, Cardenas, Maria Andrea, Beusch, Christian Michel, Hoang, Timothy N., Urban, Elizabeth A., Gourves, Mael, Nguyen, Kevin, Tharp, Gregory K., Lapp, Stacey, Rahmberg, Andrew R., Harper, Justin, del Rio Estrada, Perla M., Gonzalez-Navarro, Mauricio, Torres-Ruiz, Fernanda, Luna-Villalobos, Yara Andrea, Avila-Rios, Santiago, Reyes-Teran, Gustavo, Sekaly, Rafick, Silvestri, Guido, Kulpa, Deanna A., Saez-Cirion, Asier, Brenchley, Jason M., Bosinger, Steven E., Gordon, David Ezra, Betts, Michael R., Kissick, Haydn T., and Paiardini, Mirko

Published
2024
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2. AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques

Author

Dashti, Amir, Sukkestad, Sophia, Horner, Anna M., Neja, Margaret, Siddiqi, Zain, Waller, Chevaughn, Goldy, Jordan, Monroe, Dominique, Lin, Alice, Schoof, Nils, Singh, Vidisha, Mavigner, Maud, Lifson, Jeffrey D., Deleage, Claire, Tuyishime, Marina, Falcinelli, Shane D., King, Hannah A. D., Ke, Ruian, Mason, Rosemarie D., Archin, Nancie M., Dunham, Richard M., Safrit, Jeffrey T., Jean, Sherrie, Perelson, Alan S., Margolis, David M., Ferrari, Guido, Roederer, Mario, Silvestri, Guido, and Chahroudi, Ann

Published
2023
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4. HIV DNA persists in hepatocytes in people with HIV-hepatitis B co-infection on antiretroviral therapy

Author

Zerbato, Jennifer M., Avihingsanon, Anchalee, Singh, Kasha P., Zhao, Wei, Deleage, Claire, Rosen, Elias, Cottrell, Mackenzie L., Rhodes, Ajantha, Dantanarayana, Ashanti, Tumpach, Carolin, Tennakoon, Surekha, Crane, Megan, Price, David J., Braat, Sabine, Mason, Hugh, Roche, Michael, Kashuba, Angela D.M., Revill, Peter A., Audsley, Jennifer, and Lewin, Sharon R.

Published
2023
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5. Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques

Author

Pino, Maria, Pagliuzza, Amélie, Pampena, M. Betina, Deleage, Claire, Viox, Elise G., Nguyen, Kevin, Shim, Inbo, Zhang, Adam, Harper, Justin L., Samer, Sadia, King, Colin T., Cervasi, Barbara, Gill, Kiran P., Ehnert, Stephanie, Jean, Sherrie M., Freeman, Michael L., Lifson, Jeffrey D., Kulpa, Deanna, Betts, Michael R., Chomont, Nicolas, Lederman, Michael M., and Paiardini, Mirko

Published
2022
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7. Prolonged Mpox Disease in People With Advanced HIV: Characterization of Mpox Skin Lesions.

Author

O'Shea, Jesse, Zucker, Jason, Stampfer, Samuel, Cash-Goldwasser, Shama, Minhaj, Faisal S, Dretler, Alexandra, Cheeley, Justin, Chaudhuri, Shaoli, Gallitano, Stephanie M, Gunaratne, Shauna, Parkinson, Melissa, Epling, Brian, Morcock, David R, Sereti, Irini, and Deleage, Claire

Subjects
MONKEYPOX, TYPE I interferons, HIV, DENDRITIC cells, EPITHELIAL cells
Abstract

We report 3 complicated and prolonged cases of mpox in people with advanced human immunodeficiency virus (HIV) not on antiretroviral therapy (ART) at mpox diagnosis. Multiple medical countermeasures were used, including prolonged tecovirimat treatment and immune optimization with ART initiation. Immunofluorescence of skin biopsies demonstrated a dense immune infiltrate of predominantly myeloid and CD8+ T cells, with a strong type I interferon local response. RNAscope detected abundant replication of monkeypox virus (MPXV) in epithelial cells and dendritic cells. These data suggest that prolonged mpox in people with advanced HIV may be due to ongoing MPXV replication, warranting aggressive medical countermeasures and immune optimization. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Prolonged mpox disease in people with advanced HIV: characterization of mpox skin lesions

Author

O’Shea, Jesse, primary, Zucker, Jason, additional, Stampfer, Samuel, additional, Cash-Goldwasser, Shama, additional, Minhaj, Faisal S, additional, Dretler, Alexandra, additional, Cheeley, Justin, additional, Chaudhuri, Shaoli, additional, Gallitano, Stephanie M, additional, Gunaratne, Shauna, additional, Parkinson, Melissa, additional, Epling, Brian, additional, Morcock, David R, additional, Sereti, Irini, additional, and Deleage, Claire, additional

Published
2023
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9. Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy

Author

Harper, Justin, Ribeiro, Susan P., Chan, Chi Ngai, Aid, Malika, Deleage, Claire, Micci, Luca, Pino, Maria, Cervasi, Barbara, Raghunathan, Gopalan, Rimmer, Eric, Ayanoglu, Gulesi, Wu, Guoxin, Shenvi, Neeta, Barnard, Richard J.O., Del Prete, Gregory Q., Busman-Sahay, Kathleen, Silvestri, Guido, Kulpa, Deanna A., Bosinger, Steven E., Easley, Kirk A., Howell, Bonnie J., Gorman, Dan, Hazuda, Daria J., Estes, Jacob D., Sekaly, Rafick-Pierre, and Paiardini, Mirko

Subjects
Immunological research, Immune response -- Research, Viremia -- Measurement, Interleukin-10 -- Health aspects, Health care industry
Abstract

Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV-infected macaques, levels of IL-10 in plasma and lymph nodes (LNs) were induced by infection and not normalized with antiretroviral therapy (ART). During chronic infection, plasma IL-10 and transcriptomic signatures of IL-10 signaling were correlated with the cell-associated SIV-DNA content within LN [CD4.sup.+] memory subsets, including Tfh cells, and predicted the frequency of [CD4.sup.+] Tfh cells and their cell-associated SIV-DNA content during ART, respectively. In ART-treated rhesus macaques, cells harboring SIV-DNA by DNAscope were preferentially found in the LN B cell follicle in proximity to IL-10. Finally, we demonstrated that the in vivo neutralization of soluble IL-10 in ART-treated, SIV-infected macaques reduced B cell follicle maintenance and, by extension, LN memory [CD4.sup.+] T cells, including Tfh cells and those expressing PD-1 and CTLA-4. Thus, these data support a role for IL-10 in maintaining a pool of target cells in lymphoid tissue that serve as a niche for viral persistence. Targeting IL-10 signaling to impair [CD4.sup.+] T cell survival and improve antiviral immune responses may represent a novel approach to limit viral persistence in ART-suppressed people living with HIV., Introduction While the optimization of antiretroviral therapy (ART) has prevented AIDS and reduced HIV-related morbidities and mortality for the majority of people living with HIV (PLWH), a therapeutic regimen capable [...]

Published
2022
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10. REGIONAL ANALYSIS OF INTACT AND DEFECTIVE HIV PROVIRUSES IN THE BRAIN OF VIREMIC AND VIRALLY SUPPRESSED PEOPLE WITH HIV

Author

Angelovich, Thomas A., primary, Cochrane, Catherine R., additional, Zhou, Jingling, additional, Tumpach, Carolin, additional, Byrnes, Sarah J., additional, Jamal Eddine, Janna, additional, Waring, Emily, additional, Busman‐Sahay, Kathleen, additional, Deleage, Claire, additional, Jenkins, Trisha A., additional, Hearps, Anna C., additional, Turville, Stuart, additional, Gorry, Paul R, additional, Lewin, Sharon R., additional, Brew, Bruce J., additional, Estes, Jacob D, additional, Roche, Michael, additional, and Churchill, Melissa J., additional

Published
2023
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11. Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary

Author

Sanders-Beer, Brigitte E., primary, Archin, Nancie M., additional, Brumme, Zabrina L., additional, Busch, Michael P., additional, Deleage, Claire, additional, O'Doherty, Una, additional, Hughes, Stephen H., additional, Jerome, Keith R., additional, Jones, R. Brad, additional, Karn, Jonathan, additional, Kearney, Mary F., additional, Keele, Brandon F., additional, Kulpa, Deanna A., additional, Laird, Gregory M., additional, Li, Jonathan Z., additional, Lichterfeld, Mathias D., additional, Nussenzweig, Michel C., additional, Persaud, Deborah, additional, Yukl, Steven A., additional, Siliciano, Robert F., additional, and Mellors, John W., additional

Published
2023
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12. Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary.

Author

Sanders-Beer, Brigitte E., Archin, Nancie M., Brumme, Zabrina L., Busch, Michael P., Deleage, Claire, O'Doherty, Una, Hughes, Stephen H., Jerome, Keith R., Jones, R. Brad, Karn, Jonathan, Kearney, Mary F., Keele, Brandon F., Kulpa, Deanna A., Laird, Gregory M., Li, Jonathan Z., Lichterfeld, Mathias D., Nussenzweig, Michel C., Persaud, Deborah, Yukl, Steven A., and Siliciano, Robert F.

Abstract

Since the first HIV-cured person was reported in 2009, a strong interest in developing highly sensitive HIV and SIV reservoir assays has emerged. In particular, the question arose about the comparative value of state-of-the-art assays to measure and characterize the HIV reservoir, and how these assays can be applied to accurately detect changes in the reservoir during efforts to develop a cure for HIV infection. Second, it is important to consider the impact on the outcome of clinical trials if these relatively new HIV reservoir assays are incorporated into clinical trial endpoints and/or used for clinical decision-making. To understand the advantages and limitations and the regulatory implications of HIV reservoir assays, the National Institute of Allergy and Infectious Diseases (NIAID) sponsored and convened a meeting on September 16, 2022, to discuss the state of knowledge concerning these questions and best practices for selecting HIV reservoir assays for a particular research question or clinical trial protocol. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques

Author

Byrnes, Sarah J., primary, Busman-Sahay, Kathleen, additional, Angelovich, Thomas A., additional, Younger, Skyler, additional, Taylor-Brill, Sol, additional, Nekorchuk, Michael, additional, Bondoc, Stephen, additional, Dannay, Rachel, additional, Terry, Margaret, additional, Cochrane, Catherine R., additional, Jenkins, Trisha A., additional, Roche, Michael, additional, Deleage, Claire, additional, Bosinger, Steven E., additional, Paiardini, Mirko, additional, Brew, Bruce J., additional, Estes, Jacob D., additional, and Churchill, Melissa J., additional

Published
2023
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14. Distinct SIV-specific CD8+T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence

Author

Strongin, Zachary, Raymond Marchand, Laurence, Deleage, Claire, Pampena, M. Betina, Cardenas, Maria Andrea, Beusch, Christian Michel, Hoang, Timothy N., Urban, Elizabeth A., Gourves, Mael, Nguyen, Kevin, Tharp, Gregory K., Lapp, Stacey, Rahmberg, Andrew R., Harper, Justin, del Rio Estrada, Perla M., Gonzalez-Navarro, Mauricio, Torres-Ruiz, Fernanda, Luna-Villalobos, Yara Andrea, Avila-Rios, Santiago, Reyes-Teran, Gustavo, Sekaly, Rafick, Silvestri, Guido, Kulpa, Deanna A., Saez-Cirion, Asier, Brenchley, Jason M., Bosinger, Steven E., Gordon, David Ezra, Betts, Michael R., Kissick, Haydn T., and Paiardini, Mirko

Abstract

Human immunodeficiency virus (HIV) cure efforts are increasingly focused on harnessing CD8+T cell functions, which requires a deeper understanding of CD8+T cells promoting HIV control. Here we identifiy an antigen-responsive TOXhiTCF1+CD39+CD8+T cell population with high expression of inhibitory receptors and low expression of canonical cytolytic molecules. Transcriptional analysis of simian immunodeficiency virus (SIV)-specific CD8+T cells and proteomic analysis of purified CD8+T cell subsets identified TOXhiTCF1+CD39+CD8+T cells as intermediate effectors that retained stem-like features with a lineage relationship with terminal effector T cells. TOXhiTCF1+CD39+CD8+T cells were found at higher frequency than TCF1−CD39+CD8+T cells in follicular microenvironments and were preferentially located in proximity of SIV-RNA+cells. Their frequency was associated with reduced plasma viremia and lower SIV reservoir size. Highly similar TOXhiTCF1+CD39+CD8+T cells were detected in lymph nodes from antiretroviral therapy-naive and antiretroviral therapy-suppressed people living with HIV, suggesting this population of CD8+T cells contributes to limiting SIV and HIV persistence.

Published
2024
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18. Multiparameter immunohistochemistry analysis of HIV DNA, RNA and immune checkpoints in lymph node tissue

Author

Richardson, Zuwena A., primary, Deleage, Claire, additional, Tutuka, Candani S.A., additional, Walkiewicz, Marzena, additional, Del Río-Estrada, Perla M., additional, Pascoe, Rachel D., additional, Evans, Vanessa A., additional, Reyesteran, Gustavo, additional, Gonzales, Michael, additional, Roberts-Thomson, Samuel, additional, González-Navarro, Mauricio, additional, Torres-Ruiz, Fernanda, additional, Estes, Jacob D., additional, Lewin, Sharon R., additional, and Cameron, Paul U., additional

Published
2022
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20. Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease

Author

Wong, Chun-Shu, primary, Buckner, Clarisa M., additional, Lage, Silvia Lucena, additional, Pei, Luxin, additional, Assis, Felipe L., additional, Dahlstrom, Eric W., additional, Anzick, Sarah L., additional, Virtaneva, Kimmo, additional, Rupert, Adam, additional, Davis, Jeremy L., additional, Zhou, Ting, additional, Laidlaw, Elizabeth, additional, Manion, Maura, additional, Galindo, Frances, additional, Anderson, Megan, additional, Seamon, Catherine A., additional, Sneller, Michael C., additional, Lisco, Andrea, additional, Deleage, Claire, additional, Pittaluga, Stefania, additional, Moir, Susan, additional, and Sereti, Irini, additional

Published
2021
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24. Dual role of circulating and mucosal Vδ1 T cells in the control of and contribution to persistent HIV-1 infection.

Author

Mann BT, Sanz M, Clohosey M, Langlands K, Chitrakar A, Moreno C, Vitalle J, Iannone MA, Ruiz-Mateos E, Deleage C, Siegel M, and Soriano-Sarabia N

Abstract

Curative strategies for human immunodeficiency virus (HIV-1) infection are hindered by incomplete characterization of the latent reservoir and limited enhancement of anti-HIV immune responses. In this study, we identified a novel dual role for peripheral and tissue-resident Vδ1 T cells within the gastrointestinal mucosa of virally suppressed people with HIV. Phenotypic analyses identified an increased frequency of highly differentiated, cytotoxic effector Vδ1 T cells that exerted potent inhibition of HIV-1 replication in vitro coinciding with direct increases in cytolytic function. Conversely, we detected an enrichment of HIV-1 DNA in tissue-resident CD4+Vδ1 T cells in situ. Despite low CD4 expression, we found circulating Vδ1 T cells also contained HIV-1 DNA which was replication-competent. We show that TCR-mediated activation of peripheral Vδ1 T cells induced de novo upregulation of CD4 providing a plausible mechanism for increased permissibility to infection. These findings highlight juxtaposing roles for Vδ1 T cells in HIV-1 persistence including significant contribution to tissue reservoirs.

Published
2024
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