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124 results on '"DasGupta Bhaskar"'

1. Treat-to-target recommendations in giant cell arteritis and polymyalgia rheumatica.

Author

Dejaco, Christian, Kerschbaumer, Andreas, Aletaha, Daniel, Bond, Milena, Hysa, Elvis, Camellino, Dario, Ehlers, Lisa, Abril, Andy, Appenzeller, Simone, Cid, Maria, Dasgupta, Bhaskar, Duftner, Christina, Grayson, Peter, Hellmich, Bernhard, Hočevar, Alojzija, Kermani, Tanaz, Matteson, Eric, Mollan, Susan, Neill, Lorna, Ponte, Cristina, Salvarani, Carlo, Sattui, Sebastian, Schmidt, Wolfgang, Seo, Philip, Smolen, Josef, Thiel, Jens, Toro-Gutiérrez, Carlos, Whitlock, Madeline, and Buttgereit, Frank

Subjects
Biological Therapy, Giant Cell Arteritis, Outcome and Process Assessment, Health Care, Polymyalgia Rheumatica, Humans, Giant Cell Arteritis, Polymyalgia Rheumatica, Quality of Life, Comorbidity
Abstract

OBJECTIVES: To develop treat-to-target (T2T) recommendations in giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). METHODS: A systematic literature review was conducted to retrieve data on treatment targets and outcomes in GCA/PMR as well as to identify the evidence for the effectiveness of a T2T-based management approach in these diseases. Based on evidence and expert opinion, the task force (29 participants from 10 countries consisting of physicians, a healthcare professional and a patient) developed recommendations, with consensus obtained through voting. The final level of agreement was provided anonymously. RESULTS: Five overarching principles and six-specific recommendations were formulated. Management of GCA and PMR should be based on shared decisions between patient and physician recognising the need for urgent treatment of GCA to avoid ischaemic complications, and it should aim at maximising health-related quality of life in both diseases. The treatment targets are achievement and maintenance of remission, as well as prevention of tissue ischaemia and vascular damage. Comorbidities need to be considered when assessing disease activity and selecting treatment. CONCLUSION: These are the first T2T recommendations for GCA and PMR. Treatment targets, as well as strategies to assess, achieve and maintain these targets have been defined. The research agenda highlights the gaps in evidence and the need for future research.

Published
2024

2. Dimensional synthesis of spatial manipulators for velocity and force transmission for operation around a specified task point

Author

Jacob, Akkarapakam Suneesh and Dasgupta, Bhaskar

Subjects
Computer Science - Robotics
Abstract

Dimensional synthesis refers to design of the dimensions of manipulators by optimising different kinds of performance indices. The motivation of this study is to perform dimensional synthesis for a wide set of spatial manipulators by optimising the manipulability of each manipulator around a pre-defined task point in the workspace and to finally give a prescription of manipulators along with their dimensions optimised for velocity and force transmission. A systematic method to formulate Jacobian matrix of a manipulator is presented. Optimisation of manipulability is performed for manipulation of the end-effector around a chosen task point for 96 1-DOF manipulators, 645 2-DOF manipulators, 8 3-DOF manipulators and 15 4-DOF manipulators taken from the result of enumeration of manipulators that is done in its companion paper devoted to enumeration of possible manipulators up to a number of links. Prescriptions for these sets of manipulators are presented along with their scaled condition numbers and their ordered indices. This gives the designer a prescription of manipulators with their optimised dimensions that reflects the performance of the end-effector around the given task point for velocity and force transmission.

Published
2022

3. Enumeration of spatial manipulators by using the concept of Adjacency Matrix

Author

Jacob, Akkarapakam Suneesh, Dasgupta, Bhaskar, and Datta, Rituparna

Subjects
Computer Science - Robotics
Abstract

This study is on the enumeration of spatial robotic manipulators, which is an essential basis for a companion study on dimensional synthesis, both of which together present a wider utility in manipulator synthesis. The enumeration of manipulators is done by using adjacency matrix concept. In this paper, a novel way of applying adjacency matrix to spatial manipulators with four types of joints, namely revolute, prismatic, cylindrical and spherical joints, is presented. The limitations of the applicability of the concept to 3D manipulators are discussed. 1-DOF (Degree Of Freedom) manipulators of four links and 2-DOF, 3-DOF and 4-DOF manipulators of three links, four links and five links, are enumerated based on a set of conventions and some assumptions. Finally, 96 1-DOF manipulators of four links, 641 2-DOF manipulators of 5 links, 4 2-DOF manipulators of three links, 8 3-DOF manipulators of four links and 15 4-DOF manipulators of five links are presented.

Published
2022

4. On computing Discretized Ricci curvatures of graphs: local algorithms and (localized) fine-grained reductions

Author

DasGupta, Bhaskar, Grigorescu, Elena, and Mukherjee, Tamalika

Subjects
Computer Science - Data Structures and Algorithms, Computer Science - Computational Complexity, 68Q25, 68Q17, 68W25, 68W20, 68W40
Abstract

Characterizing shapes of high-dimensional objects via Ricci curvatures plays a critical role in many research areas in mathematics and physics. However, even though several discretizations of Ricci curvatures for discrete combinatorial objects such as networks have been proposed and studied by mathematicians, the computational complexity aspects of these discretizations have escaped the attention of theoretical computer scientists to a large extent. In this paper, we study one such discretization, namely the Ollivier-Ricci curvature, from the perspective of efficient computation by fine-grained reductions and local query-based algorithms. Our main contributions are the following. (a) We relate our curvature computation problem to minimum weight perfect matching problem on complete bipartite graphs via fine-grained reduction. (b) We formalize the computational aspects of the curvature computation problems in suitable frameworks so that they can be studied by researchers in local algorithms. (c) We provide the first known lower and upper bounds on queries for query-based algorithms for the curvature computation problems in our local algorithms framework. En route, we also illustrate a localized version of our fine-grained reduction. We believe that our results bring forth an intriguing set of research questions, motivated both in theory and practice, regarding designing efficient algorithms for curvatures of objects., Comment: To appear in the journal "Theoretical Computer Science"

Published
2022

5. Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study

Author

Callejas, José Luis, Caminal-Montero, Luis, Corbera-Bellalta, Marc, de Miguel, Eugenio, Díaz-López, J. Bernardino, García-Villanueva, María Jesús, Gómez-Vaquero, Carmen, Guijarro-Rojas, Mercedes, Hidalgo-Conde, Ana, Marí-Alfonso, Begoña, Martínez-Berriochoa, Agustín, Morado, Inmaculada C., Narváez, Javier, Ramentol-Sintas, Marc, Martínez-Zapico, Aleida, Martínez-Taboada, Víctor Manuel, Miranda-Filloy, José A., Monfort, Jordi, Pérez-Conesa, Mercedes, Prieto-González, Sergio, Raya, Enrique, Ríos-Fenández, Raquel, Sánchez-Martín, Julio, Sopeña, Bernardo, Tío, Laura, Unzurrunzaga, Ainhoa, Wordsworth, Oliver, Whitwell, Isobel, Brock, Jessica, Douglas, Victoria, Hettiarachchi, Chamila, Bartholomew, Jacqui, Jarrett, Stephen, Smithson, Gayle, Green, Michael, Brown, Pearl Clark, Lawson, Cathy, Gordon, Esther, Lane, Suzanne, Francis, Rebecca, Dasgupta, Bhaskar, Masunda, Bridgett, Calver, Jo, Patel, Yusuf, Thompson, Charlotte, Gregory, Louise, Levy, Sarah, Menon, Ajit, Thompson, Amy, Dyche, Lisa, Martin, Michael, Li, Charles, Laxminarayan, Ramasharan, Wilcox, Louise, de Guzman, Ralph, Isaacs, John, Lorenzi, Alice, Farley, Ross, Hinchcliffe-Hume, Helain, Bejarano, Victoria, Hope, Susan, Nandi, Pradip, Stockham, Lynne, Wilde, Catherine, Durrant, Donna, Lloyd, Mark, Ye, Chee-Seng, Stevens, Rob, Jilani, Amjad, Collins, David, Pegler, Suzannah, Rivett, Ali, Price, Liz, McHugh, Neil, Skeoch, Sarah, O'Kane, Diana, Kirkwood, Sue, Vadivelu, Saravanan, Pugmire, Susan, Sultan, Shabina, Dooks, Emma, Armstrong, Lisa, Sadik, Hala, Nandagudi, Anupama, Abioye, Tolu, Ramos, Angelo, Gumus, Steph, Sofat, Nidhi, Harrison, Abiola, Seward, Abi, Mollan, Susan, Rahan, Ray, Hawkins, Helen, Emsley, Hedley, Bhargava, Anna, Fleming, Vicki, Hare, Marianne, Raj, Sonia, George, Emmanuel, Allen, Nicola, Hunter, Karl, O'Sullivan, Eoin, Bird, Georgina, Magliano, Malgorzata, Manzo, Katarina, Sanghera, Bobbie, Hutchinson, David, Hammonds, Fiona, Sharma, Poonam, Cooper, Richard, McLintock, Graeme, Al-Saffar, Zaid S., Green, Mike, Elliott, Kerry, Neale, Tania, Mallinson, Janine, Lanyon, Peter, Pradere, Marie-Josephe, Jordan, Natasha, Htut, Ei Phyu, Mushapaidzi, Thelma, Abercrombie, Donna, Wright, Sam, Rowlands, Jane, Mukhtyar, Chetan, Kennedy, James, Makkuni, Damodar, Wilhelmsen, Elva, Kouroupis, Michael, John, Lily, Hughes, Rod, Walsh, Margaret, Buckley, Marie, Mackay, Kirsten, Camden-Woodley, Tracey, Redome, Joan, Pearce, Kirsty, Marianayagam, Thiraupathy, Cruz, Carina, Warner, Elizabeth, Atchia, Ishmael, Walker, Claire, Black, Karen, Duffy, Stacey, Fothergill, Lynda, Jefferey, Rebecca, Toomey, Jackie, Rhys-Dillon, Ceril, Pothecary, Carla, Green, Lauren, Toms, Tracey, Maher, Linda, Davis, Diana, Sayan, Amrinder, Thankachen, Mini, Abusalameh, Mahdi, Record, Jessica, Khan, Asad, Stafford, Sam, Hussein, Azza, Williams, Clare, Fletcher, Alison, Johson, Laura, Burnett, Richard, Moots, Robert, Frankland, Helen, Dale, James, Moar, Kirsten, Hollas, Carol, Parker, Ben, Ridings, Derek, Eapen, Sandhya, John, Sindhu, Robson, Jo, Guthrie, Lucy Belle, Fyfe, Rose, Tait, Moira, Marks, Jonathan, Gunter, Emma, Hernandez, Rochelle, Bhat, Smita, Johnston, Paul, Khurshid, Muhammad, Barclay, Charlotte, Kapur, Deepti, Jeffrey, Helen, Hughes, Anna, Slack, Lauren, Thomas, Eleri, Royon, Anna, Hall, Angela, King, Jon, Nyathi, Sindi, Morris, Vanessa, Castelino, Madhura, Hawkins, Ellie, Tomson, Linda, Singh, Animesh, Nunag, Annalyn, O'Connor, Stella, Rushby, Nathan, Hewitson, Nicola, O'Sunmboye, Kenny, Lewszuk, Adam, Boyles, Louise, Perry, Martin, Williams, Emma, Graver, Christine, Defever, Emmanuel, Kamanth, Sanjeet, Kay, Dominic, Ogor, Joe, Winter, Louise, Horton, Sarah, Welch, Gillian, Hollinshead, Kath, Peters, James, Labao, Julius, Dmello, Andrea, Dawson, Julie, Graham, Denise, De Lord, Denise, Deery, Jo, Hazelton, Tracy, Carette, Simon, Chung, Sharon, Cuthbertson, David, Forbess, Lindsy J., Gewurz-Singer, Ora, Hoffman, Gary S., Koening, Curry L., Maksimowicz-McKinnon, Kathleen M., McAlear, Carol A., Moreland, Larry W., Pagnoux, Christian, Seo, Philip, Specks, Ulrich, Spiera, Robert F., Sreih, Antoine, Warrington, Kenneth J., Monach, Paul A., Weisman, Michael, Borrego-Yaniz, Gonzalo, Ortiz-Fernández, Lourdes, Madrid-Paredes, Adela, Kerick, Martin, Hernández-Rodríguez, José, Mackie, Sarah L, Vaglio, Augusto, Castañeda, Santos, Solans, Roser, Mestre-Torres, Jaume, Khalidi, Nader, Langford, Carol A, Ytterberg, Steven, Beretta, Lorenzo, Govoni, Marcello, Emmi, Giacomo, Cimmino, Marco A, Witte, Torsten, Neumann, Thomas, Holle, Julia, Schönau, Verena, Pugnet, Gregory, Papo, Thomas, Haroche, Julien, Mahr, Alfred, Mouthon, Luc, Molberg, Øyvind, Diamantopoulos, Andreas P, Voskuyl, Alexandre, Daikeler, Thomas, Berger, Christoph T, Molloy, Eamonn S, Blockmans, Daniel, van Sleen, Yannick, Iles, Mark, Sorensen, Louise, Luqmani, Raashid, Reynolds, Gary, Bukhari, Marwan, Bhagat, Shweta, Ortego-Centeno, Norberto, Brouwer, Elisabeth, Lamprecht, Peter, Klapa, Sebastian, Salvarani, Carlo, Merkel, Peter A, Cid, María C, González-Gay, Miguel A, Morgan, Ann W, Martin, Javier, and Márquez, Ana

Published
2024
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6. A phase 3 randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of sarilumab in patients with giant cell arteritis

Author

Schmidt, Wolfgang A., Dasgupta, Bhaskar, Sloane, Jennifer, Giannelou, Angeliki, Xu, Yuqing, Unizony, Sebastian H., Mackie, Sarah L., Gonzalez-Gay, Miguel A., Spiera, Robert, Warrington, Kenneth J., Villiger, Peter M., Nivens, Michael C., Akinlade, Bolanle, Lin, Yong, Buttgereit, Frank, and Stone, John H.

Published
2023
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8. Development of a diagnostic prediction model for giant cell arteritis by sequential application of Southend Giant Cell Arteritis Probability Score and ultrasonography: a prospective multicentre study

Author

Sebastian, Alwin, van der Geest, Kornelis S M, Tomelleri, Alessandro, Macchioni, Pierluigi, Klinowski, Giulia, Salvarani, Carlo, Prieto-Peña, Diana, Conticini, Edoardo, Khurshid, Muhammad, Dagna, Lorenzo, Brouwer, Elisabeth, and Dasgupta, Bhaskar

Published
2024
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11. Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials

Author

Zayat, Ahmed, Machado, Ana Rita, Cuervo, Andrea, Mahto, Arti, Cubuk, Cankut, Rawlings, Charlotte, Mosanya, Chijioke, Buckley, Chris, Holroyd, Chris, Maskall, Debbie, Carlucci, Francesco, Thorborn, Georgina, Tan, Gina, Lliso-Ribera, Gloria, Rizvi, Hasan, Peel, Joanna, Fonseca, João Eurico, Isaacs, John, Ramírez, Julio, Meric de Bellefon, Laurent, Fossati-Jimak, Liliane, Githinji, Mary, Congia, Mattia, Millar, Neal, Purkayastha, Nirupam, Celis, Raquel, Seth, Rakhi, Hands-Greenwood, Rebecca, Landewé, Robert, Perniola, Simone, Alivernini, Stefano, Marcia, Stefano, Marini, Stefano, Kelly, Stephen, Romão, Vasco, Rivellese, Felice, Nerviani, Alessandra, Giorli, Giovanni, Warren, Louise, Jaworska, Edyta, Bombardieri, Michele, Lewis, Myles J, Humby, Frances, Pratt, Arthur G, Filer, Andrew, Gendi, Nagui, Cauli, Alberto, Choy, Ernest, McInnes, Iain, Durez, Patrick, Edwards, Christopher J, Buch, Maya H, Gremese, Elisa, Taylor, Peter C, Ng, Nora, Cañete, Juan D, Raizada, Sabrina, McKay, Neil D, Jadon, Deepak, Sainaghi, Pier Paolo, Stratton, Richard, Ehrenstein, Michael R, Ho, Pauline, Pereira, Joaquim P, Dasgupta, Bhaskar, Gorman, Claire, Galloway, James, Chinoy, Hector, van der Heijde, Désirée, Sasieni, Peter, Barton, Anne, and Pitzalis, Costantino

Published
2023
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16. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Au Peh, Chen, Chakera, Aron, Cooper, Bruce, Kurtkoti, Jagadeesh, Langguth, Daman, Levidiotis, Vicki, Luxton, Grant, Mount, Peter, Mudge, David, Noble, Euan, Phoon, Richard, Ranganathan, Dwarakanathan, Ritchie, Angus, Ryan, Jessica, Suranyi, Michael, Rosenkranz, Alexander, Lhotta, Karl, Kronbichler, Andreas, Demoulin, Nathalie, Bovy, Christophe, Hellemans, Rachel, Hougardy, Jean-Michel, Sprangers, Ben, Wissing, Karl Martin, Pagnoux, Christian, Barbour, Sean, Brachemi, Soumeya, Cournoyer, Serge, Girard, Louis-Philippe, Laurin, Louis-Philippe, Liang, Patrick, Philibert, David, Walsh, Michael, Tesar, Vladimir, Becvar, Radim, Horak, Pavel, Rychlik, Ivan, Szpirt, Wladimir, Dieperink, Hans, Gregersen, Jon Waarst, Ivarsen, Per, Krarup, Elizabeth, Lyngsoe, Cecilie, Rigothier, Claire, Augusto, Jean-Francois, Belot, Alexandre, Chauveau, Dominique, Cornec, Divi, Jourde-Chiche, Noemie, Ficheux, Maxence, Karras, Alexandre, Klein, Alexandre, Maurier, Francois, Mesbah, Rafik, Moranne, Olivier, Neel, Antoine, Quemeneur, Thomas, Saadoun, David, Terrier, Benjamin, Zaoui, Philippe, Schaier, Matthias, Benck, Urs Tobias, Bergner, Raoul, Busch, Martin, Floege, Juergen, Grundmann, Franziska, Haller, Hermann, Haubitz, Marion, Hellmich, Bernhard, Henes, Joerg Christoph, Hohenstein, Bernd, Hugo, Christian, Iking-Konert, Christof, Arndt, Fabian, Kubacki, T, Kotter, Ina, Lamprecht, Peter, Lindner, Tom, Halbritter, Jan, Mehling, Heidrun, Schönermarck, Ulf, Venhoff, Nils, Vielhauer, Volker, Witzke, Oliver, Szombati, Istvan, Szucs, Gabriella, Garibotto, Giacomo, Alberici, Federico, Brunetta, Enrico, Dagna, Lorenzo, De Vita, Salvatore, Emmi, Giacomo, Gabrielli, Armando, Manenti, Lucio, Pieruzzi, Federico, Roccatello, Dario, Salvarani, Carlo, Harigai, Masayoshi, Dobashi, Hiroaki, Atsumi, Tatsuya, Fujimoto, Shoichi, Hagino, Noboru, Ihata, Atsushi, Kaname, Shinya, Kaneko, Yuko, Katagiri, Akira, Katayama, Masao, Kirino, Yohei, Kitagawa, Kiyoki, Komatsuda, Atsushi, Kono, Hajime, Kurasawa, Takahiko, Matsumura, Ryutaro, Mimura, Toshihide, Morinobu, Akio, Murakawa, Yohko, Naniwa, Taio, Nanki, Toshihiro, Ogawa, Noriyoshi, Oshima, Hisaji, Sada, Kenei, Sugiyama, Eiji, Takeuchi, Tohru, Taki, Hirofumi, Tamura, Naoto, Tsukamoto, Tatsuo, Yamagata, Kunihiro, Yamamura, Masahiro, van Daele, Paulus Leon Arthur, Rutgers, Abraham, Teng, Y.K. Onno, Walker, Robert, Chua, Ignatius, Collins, Michael, Rabindranath, Kannaiyan, de Zoysa, Janak, Svensson, My Hanna Sofia, Grevbo, Bard-Waldum, Kalstad, Synove, Little, Mark, Clarkson, Michael, Molloy, Eamonn, Agraz Pamplona, Irene, Anton, Jordi, Barrio Lucia, Vicente, Ciggaran, Secundino, Cinta Cid, Maria, Diaz Encarnacion, Montserrat, Fulladosa Oliveras, Xavier, Jose Soler, Maria, Marco Rusinol, Helena, Praga, Manuel, Quintana Porras, Luis, Segarra, Alfons, Bruchfeld, Annette, Segelmark, Marten, Soveri, Inga, Thomaidi, Eleni, Westman, Kerstin, Neumann, Thomas, Burnier, Michel, Daikeler, Thomas, Dudler, Jean, Hauser, Thomas, Seeger, Harald, Vogt, Bruno, Burton, James, Al Jayyousi, Reem, Amin, Tania, Andrews, Jacqueline, Baines, Laura Anne, Brogan, Paul, Dasgupta, Bhaskar, Doulton, Timothy William Ronald, Flossmann, Oliver, Griffin, Sian V., Harper, Janice Marian, Harper, Lorraine, Kidder, Dana, Klocke, Rainer, Lanyon, Peter Charles, Luqmani, Raashid, McLaren, John Stuart, Makanjuola, David Osagie, McCann, Liza, Nandagudi, Anupama C., Selvan, Shilpa, O'Riordan, Edmond, Patel, Mumtaz, Patel, Rajan Kantilal, Pusey, Charles Dickson, Rajakariar, Ravindra, Robson, Joanna C., Robson, Michael, Salama, Alan David, Smyth, Lucy, Sznajd, Jan, Taylor, Joanne, Sreih, Antonie G., Belilos, Elise, Bomback, Andrew S., Carlin, Jeffrey, Chang Chen Lin, Yih, Derebail, Vimal K., Dragoi, Serban, Dua, Anisha, Forbess, Lindsy, Geetha, Duvuru, Gipson, Patrick, Gohh, Reginald, Greenwood, Gregory Todd, Hugenberg, Steven T., Jimenez, Richard A.H., Kaskas, Marwan Omar, Kermani, Tanaz, Kivitz, Alan J., Koening, Curry, Langford, Carol A., Marder, Galina, Mohamed, Amr Ahmed El-Huesseini, Monach, Paul, Neyra, Nilda Roxana, Niemer, Gregory W., Niles, John, Obi, Reginald, Owens, Charles, Parks, Deborah L., Podoll, Amber S., Rovin, Brad, Sam, R, Shergy, William Julius, Silva, Arnold Lawrence, Specks, Ulrich, Spiera, Robert, Springer, Jason M., Striebich, Christopher Charles, Swarup, Areena, Thakar, Surabhi, Tiliakos, Athan N., Tsai, Yong, Waguespack, Dia R., Chester Wasko, Mary, Strand, Vibeke, Jayne, David R W, Horomanski, Audra, Yue, Huibin, Bekker, Pirow, and Merkel, Peter A

Published
2023
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17. Early infection risk in patients with systemic lupus erythematosus treated with rituximab or belimumab from the British Isles Lupus Assessment Group Biologics Register (BILAG-BR): a prospective longitudinal study

Author

Abernethy, Rikki, Ahmad, Yasmeen, Akil, Mohamed, Bartram, Sarah, Batley, Mike, Bharadwaj, Anurag, Bruce, Ian, Carlucci, Francesco, Chan, Antoni, Dasgupta, Bhaskar, D'Cruz, David, De Lord, Denise, Dyke, Bernard, Edwards, Christopher, Erb, Nicola, Farrell, Adrian, Gayed, Mary, Gendi, Nagui, Gompels, Luke, Gordon, Caroline, Gordon, Patrick, Griffiths, Bridget, Gullick, Nicola, Gunwardena, Harsha, Haigh, Richard, Hamdulay, Shahir, Haque, Sahena, Hutchinson, David, Isenberg, David, Jayne, David, Jeffery, Rachel, Kapur, Deepti, Kaul, Arvind, King, Jon, Knights, Sally, Korendowych, Ellie, Lanyon, Peter, Mahindrakar, Madhu, Marks, Jonathan, McCann, Liza, McLaren, Zoe, Mediwake, Rapti, Menon, Ajit, Mewar, Devesh, Min, Steven Young, Nair, Jagdish, O'Riordan, Edmond, Pyne, Dev, Rahmeh, Fouz, Regan, Marian, Reynolds, John, Rhodes, Ben, Rhys-Dillon, Ceril, Robson, Joanna C, Shaffu, Shireen, Sheeran, T, Skeoch, Sarah, Sood, Bhrigu Raj, Stratton, Richard, Teh, Lee-Suan, Vermaak, Erin, Vital, Ed, Waller, Rosemary, Watts, Richard, Wijeyekoon, Jananath, Yee, Chee-Seng, Yong, Cee Yi, Youssef, Hazem, Yusuf, Abid, Zoma, Asad, Rodziewicz, Mia, Dyball, Sarah, Lunt, Mark, McDonald, Stephen, Sutton, Emily, Parker, Ben, and Bruce, Ian N

Published
2023
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20. Valuing Health Gain from Composite Response Endpoints for Multisystem Diseases

Author

Bruce, Ian, Payne, Katherine, Lunt, Mark, Peek, Niels, Geifman, Nophar, Gavan, Sean, Armitt, Gillian, Doherty, Patrick, Prattley, Jennifer, Azadbakht, Narges, Papazian, Angela, Le Sueur, Helen, Farrelly, Carmen, Richardson, Clare, Shabbir, Zunnaira, Hewitt, Lauren, McHugh, Neil, Gordon, Caroline, Reynolds, John, Young, Stephen, Jayne, David, Farewell, Vern, Su, Li, Pickering, Matthew, Lightstone, Elizabeth, Gilmore, Alyssa, Botto, Marina, Vyse, Timothy, Morris, David Lester, D’Cruz, David, Vital, Edward, Wittmann, Miriam, Emery, Paul, Beresford, Michael, Hedrich, Christian, Midgley, Angela, Gritzfeld, Jenna, Ehrenstein, Michael, Isenberg, David, Parvaz, Mariea, Dunnage, Jane, Batchelor, Jane, Holland, Elaine, Upsall, Pauline, Youssef, Hazem, McCann, Liza, Mediwake, Rapti, Bharadwaj, Anurag, Vital, Ed, Kapur, Deepti, Chee-Seng Yee, Prof, Griffiths, Bridget, Yusuf, Abid, Zoma, Asad, Vermaak, Erin, Carlucci, Francesco, Watts, Richard, Gordon, Patrick, Shaffu, Shireen, Wijeyekoon, Jananath, McLaren, Zoe, Ahmad, Yasmeen, Batley, Mike, Gompels, Luke, Sheeran, T., Yi Yong, Cee, Jeffery, Rachel, Hamdulay, Shahir, Rahmeh, Fouz, Young Min, Steven, Rhodes, Ben, De Lord, Denise, Lanyon, Peter, Chan, Antoni, Teh, Lee-Suan, Marks, Jonathan, Hutchinson, David, Regan, Marian, Haigh, Richard, Stratton, Richard, Rhys-Dillon, Ceril, Akil, Mohamed, Mewar, Devesh, Skeoch, Sarah, Erb, Nicola, O’Riordan, Edmond, Bartram, Sarah, Gayed, Mary, Dasgupta, Bhaskar, Gunwardena, Harsha, Pyne, Dev, Kaul, Arvind, Mahindrakar, Madhu, Raj Sood, Bhrigu, Gullick, Nicola, Edwards, Christopher, Joanna C Robson, King, Jon, Farrell, Adrian, Haque, Sahena, Knights, Sally, Gavan, Sean P., and Bruce, Ian N.

Published
2023
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23. Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study

Author

Borrego-Yaniz, Gonzalo, primary, Ortiz-Fernández, Lourdes, additional, Madrid-Paredes, Adela, additional, Kerick, Martin, additional, Hernández-Rodríguez, José, additional, Mackie, Sarah L, additional, Vaglio, Augusto, additional, Castañeda, Santos, additional, Solans, Roser, additional, Mestre-Torres, Jaume, additional, Khalidi, Nader, additional, Langford, Carol A, additional, Ytterberg, Steven, additional, Beretta, Lorenzo, additional, Govoni, Marcello, additional, Emmi, Giacomo, additional, Cimmino, Marco A, additional, Witte, Torsten, additional, Neumann, Thomas, additional, Holle, Julia, additional, Schönau, Verena, additional, Pugnet, Gregory, additional, Papo, Thomas, additional, Haroche, Julien, additional, Mahr, Alfred, additional, Mouthon, Luc, additional, Molberg, Øyvind, additional, Diamantopoulos, Andreas P, additional, Voskuyl, Alexandre, additional, Daikeler, Thomas, additional, Berger, Christoph T, additional, Molloy, Eamonn S, additional, Blockmans, Daniel, additional, van Sleen, Yannick, additional, Iles, Mark, additional, Sorensen, Louise, additional, Luqmani, Raashid, additional, Reynolds, Gary, additional, Bukhari, Marwan, additional, Bhagat, Shweta, additional, Ortego-Centeno, Norberto, additional, Brouwer, Elisabeth, additional, Lamprecht, Peter, additional, Klapa, Sebastian, additional, Salvarani, Carlo, additional, Merkel, Peter A, additional, Cid, María C, additional, González-Gay, Miguel A, additional, Morgan, Ann W, additional, Martin, Javier, additional, Márquez, Ana, additional, Callejas, José Luis, additional, Caminal-Montero, Luis, additional, Corbera-Bellalta, Marc, additional, de Miguel, Eugenio, additional, Díaz-López, J. Bernardino, additional, García-Villanueva, María Jesús, additional, Gómez-Vaquero, Carmen, additional, Guijarro-Rojas, Mercedes, additional, Hidalgo-Conde, Ana, additional, Marí-Alfonso, Begoña, additional, Martínez-Berriochoa, Agustín, additional, Morado, Inmaculada C., additional, Narváez, Javier, additional, Ramentol-Sintas, Marc, additional, Martínez-Zapico, Aleida, additional, Martínez-Taboada, Víctor Manuel, additional, Miranda-Filloy, José A., additional, Monfort, Jordi, additional, Pérez-Conesa, Mercedes, additional, Prieto-González, Sergio, additional, Raya, Enrique, additional, Ríos-Fenández, Raquel, additional, Sánchez-Martín, Julio, additional, Sopeña, Bernardo, additional, Tío, Laura, additional, Unzurrunzaga, Ainhoa, additional, Wordsworth, Oliver, additional, Whitwell, Isobel, additional, Brock, Jessica, additional, Douglas, Victoria, additional, Hettiarachchi, Chamila, additional, Bartholomew, Jacqui, additional, Jarrett, Stephen, additional, Smithson, Gayle, additional, Green, Michael, additional, Brown, Pearl Clark, additional, Lawson, Cathy, additional, Gordon, Esther, additional, Lane, Suzanne, additional, Francis, Rebecca, additional, Dasgupta, Bhaskar, additional, Masunda, Bridgett, additional, Calver, Jo, additional, Patel, Yusuf, additional, Thompson, Charlotte, additional, Gregory, Louise, additional, Levy, Sarah, additional, Menon, Ajit, additional, Thompson, Amy, additional, Dyche, Lisa, additional, Martin, Michael, additional, Li, Charles, additional, Laxminarayan, Ramasharan, additional, Wilcox, Louise, additional, de Guzman, Ralph, additional, Isaacs, John, additional, Lorenzi, Alice, additional, Farley, Ross, additional, Hinchcliffe-Hume, Helain, additional, Bejarano, Victoria, additional, Hope, Susan, additional, Nandi, Pradip, additional, Stockham, Lynne, additional, Wilde, Catherine, additional, Durrant, Donna, additional, Lloyd, Mark, additional, Ye, Chee-Seng, additional, Stevens, Rob, additional, Jilani, Amjad, additional, Collins, David, additional, Pegler, Suzannah, additional, Rivett, Ali, additional, Price, Liz, additional, McHugh, Neil, additional, Skeoch, Sarah, additional, O'Kane, Diana, additional, Kirkwood, Sue, additional, Vadivelu, Saravanan, additional, Pugmire, Susan, additional, Sultan, Shabina, additional, Dooks, Emma, additional, Armstrong, Lisa, additional, Sadik, Hala, additional, Nandagudi, Anupama, additional, Abioye, Tolu, additional, Ramos, Angelo, additional, Gumus, Steph, additional, Sofat, Nidhi, additional, Harrison, Abiola, additional, Seward, Abi, additional, Mollan, Susan, additional, Rahan, Ray, additional, Hawkins, Helen, additional, Emsley, Hedley, additional, Bhargava, Anna, additional, Fleming, Vicki, additional, Hare, Marianne, additional, Raj, Sonia, additional, George, Emmanuel, additional, Allen, Nicola, additional, Hunter, Karl, additional, O'Sullivan, Eoin, additional, Bird, Georgina, additional, Magliano, Malgorzata, additional, Manzo, Katarina, additional, Sanghera, Bobbie, additional, Hutchinson, David, additional, Hammonds, Fiona, additional, Sharma, Poonam, additional, Cooper, Richard, additional, McLintock, Graeme, additional, Al-Saffar, Zaid S., additional, Green, Mike, additional, Elliott, Kerry, additional, Neale, Tania, additional, Mallinson, Janine, additional, Lanyon, Peter, additional, Pradere, Marie-Josephe, additional, Jordan, Natasha, additional, Htut, Ei Phyu, additional, Mushapaidzi, Thelma, additional, Abercrombie, Donna, additional, Wright, Sam, additional, Rowlands, Jane, additional, Mukhtyar, Chetan, additional, Kennedy, James, additional, Makkuni, Damodar, additional, Wilhelmsen, Elva, additional, Kouroupis, Michael, additional, John, Lily, additional, Hughes, Rod, additional, Walsh, Margaret, additional, Buckley, Marie, additional, Mackay, Kirsten, additional, Camden-Woodley, Tracey, additional, Redome, Joan, additional, Pearce, Kirsty, additional, Marianayagam, Thiraupathy, additional, Cruz, Carina, additional, Warner, Elizabeth, additional, Atchia, Ishmael, additional, Walker, Claire, additional, Black, Karen, additional, Duffy, Stacey, additional, Fothergill, Lynda, additional, Jefferey, Rebecca, additional, Toomey, Jackie, additional, Rhys-Dillon, Ceril, additional, Pothecary, Carla, additional, Green, Lauren, additional, Toms, Tracey, additional, Maher, Linda, additional, Davis, Diana, additional, Sayan, Amrinder, additional, Thankachen, Mini, additional, Abusalameh, Mahdi, additional, Record, Jessica, additional, Khan, Asad, additional, Stafford, Sam, additional, Hussein, Azza, additional, Williams, Clare, additional, Fletcher, Alison, additional, Johson, Laura, additional, Burnett, Richard, additional, Moots, Robert, additional, Frankland, Helen, additional, Dale, James, additional, Moar, Kirsten, additional, Hollas, Carol, additional, Parker, Ben, additional, Ridings, Derek, additional, Eapen, Sandhya, additional, John, Sindhu, additional, Robson, Jo, additional, Guthrie, Lucy Belle, additional, Fyfe, Rose, additional, Tait, Moira, additional, Marks, Jonathan, additional, Gunter, Emma, additional, Hernandez, Rochelle, additional, Bhat, Smita, additional, Johnston, Paul, additional, Khurshid, Muhammad, additional, Barclay, Charlotte, additional, Kapur, Deepti, additional, Jeffrey, Helen, additional, Hughes, Anna, additional, Slack, Lauren, additional, Thomas, Eleri, additional, Royon, Anna, additional, Hall, Angela, additional, King, Jon, additional, Nyathi, Sindi, additional, Morris, Vanessa, additional, Castelino, Madhura, additional, Hawkins, Ellie, additional, Tomson, Linda, additional, Singh, Animesh, additional, Nunag, Annalyn, additional, O'Connor, Stella, additional, Rushby, Nathan, additional, Hewitson, Nicola, additional, O'Sunmboye, Kenny, additional, Lewszuk, Adam, additional, Boyles, Louise, additional, Perry, Martin, additional, Williams, Emma, additional, Graver, Christine, additional, Defever, Emmanuel, additional, Kamanth, Sanjeet, additional, Kay, Dominic, additional, Ogor, Joe, additional, Winter, Louise, additional, Horton, Sarah, additional, Welch, Gillian, additional, Hollinshead, Kath, additional, Peters, James, additional, Labao, Julius, additional, Dmello, Andrea, additional, Dawson, Julie, additional, Graham, Denise, additional, De Lord, Denise, additional, Deery, Jo, additional, Hazelton, Tracy, additional, Carette, Simon, additional, Chung, Sharon, additional, Cuthbertson, David, additional, Forbess, Lindsy J., additional, Gewurz-Singer, Ora, additional, Hoffman, Gary S., additional, Koening, Curry L., additional, Maksimowicz-McKinnon, Kathleen M., additional, McAlear, Carol A., additional, Moreland, Larry W., additional, Pagnoux, Christian, additional, Seo, Philip, additional, Specks, Ulrich, additional, Spiera, Robert F., additional, Sreih, Antoine, additional, Warrington, Kenneth J., additional, Monach, Paul A., additional, and Weisman, Michael, additional

Published
2024
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24. EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice: 2023 update.

Author

Dejaco, Christian, Ramiro, Sofia, Bond, Milena, Bosch, Philipp, Ponte, Cristina, Mackie, Sarah Louise, Bley, Thorsten A., Blockmans, Daniel, Brolin, Sara, Cagri Bolek, Ertugrul, Cassie, Rebecca, Cid, Maria C., Molina-Collada, Juan, Dasgupta, Bhaskar, Dalsgaard Nielsen, Berit, De Miguel, Eugenio, Direskeneli, Haner, Duftner, Christina, Hočevar, Alojzija, and Molto, Anna

Published
2024
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25. Enhancing rheumatology training: The POCRUS model for integrating ultrasound into clinical practice. (From APLAR imaging SIG).

Author

Lee, Anita, Kong, Kok Ooi, Chew, Li‐Ching, Ikeda, Kei, Abogamal, Ahmed, Balint, Peter V., Harifi, Ghita, Khurshid, Muhammad Asim, Lai, Kuo‐Lung, Lee, Ka‐Wing Gavin, Wakefield, Richard J., and Dasgupta, Bhaskar

Subjects
RHEUMATOLOGY, PSORIATIC arthritis, POLYMYALGIA rheumatica, ULTRASONIC imaging, JOINTS (Anatomy), GIANT cell arteritis, KNEE joint
Abstract

This document explores the use of ultrasound (US) in rheumatology practice, specifically focusing on a new model called Point of Care US (POCUS) in Rheumatology (POCRUS). The authors argue that learning US examination skills can improve diagnostic accuracy and clinical confidence in rheumatology. They propose a probability-directed approach to US, using standardized assessments based on international classification criteria for rheumatic and musculoskeletal diseases. The document acknowledges the support of various organizations in organizing and reporting the findings of an online course on POCRUS. [Extracted from the article]

Published
2024
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26. Diagnostic accuracy of OGUS, Southend halo score and halo count in giant cell arteritis

Author

Conticini, Edoardo, primary, Falsetti, Paolo, additional, Al Khayyat, Suhel Gabriele, additional, Grazzini, Silvia, additional, Baldi, Caterina, additional, Bellisai, Francesca, additional, Gentileschi, Stefano, additional, Bardelli, Marco, additional, Fabiani, Claudia, additional, Cantarini, Luca, additional, Dasgupta, Bhaskar, additional, and Frediani, Bruno, additional

Published
2024
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29. Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials

Author

Rivellese, Felice, primary, Nerviani, Alessandra, additional, Giorli, Giovanni, additional, Warren, Louise, additional, Jaworska, Edyta, additional, Bombardieri, Michele, additional, Lewis, Myles J, additional, Humby, Frances, additional, Pratt, Arthur G, additional, Filer, Andrew, additional, Gendi, Nagui, additional, Cauli, Alberto, additional, Choy, Ernest, additional, McInnes, Iain, additional, Durez, Patrick, additional, Edwards, Christopher J, additional, Buch, Maya H, additional, Gremese, Elisa, additional, Taylor, Peter C, additional, Ng, Nora, additional, Cañete, Juan D, additional, Raizada, Sabrina, additional, McKay, Neil D, additional, Jadon, Deepak, additional, Sainaghi, Pier Paolo, additional, Stratton, Richard, additional, Ehrenstein, Michael R, additional, Ho, Pauline, additional, Pereira, Joaquim P, additional, Dasgupta, Bhaskar, additional, Gorman, Claire, additional, Galloway, James, additional, Chinoy, Hector, additional, van der Heijde, Désirée, additional, Sasieni, Peter, additional, Barton, Anne, additional, Pitzalis, Costantino, additional, Zayat, Ahmed, additional, Machado, Ana Rita, additional, Cuervo, Andrea, additional, Mahto, Arti, additional, Cubuk, Cankut, additional, Rawlings, Charlotte, additional, Mosanya, Chijioke, additional, Buckley, Chris, additional, Holroyd, Chris, additional, Maskall, Debbie, additional, Carlucci, Francesco, additional, Thorborn, Georgina, additional, Tan, Gina, additional, Lliso-Ribera, Gloria, additional, Rizvi, Hasan, additional, Peel, Joanna, additional, Fonseca, João Eurico, additional, Isaacs, John, additional, Ramírez, Julio, additional, Meric de Bellefon, Laurent, additional, Fossati-Jimak, Liliane, additional, Githinji, Mary, additional, Congia, Mattia, additional, Millar, Neal, additional, Purkayastha, Nirupam, additional, Celis, Raquel, additional, Seth, Rakhi, additional, Hands-Greenwood, Rebecca, additional, Landewé, Robert, additional, Perniola, Simone, additional, Alivernini, Stefano, additional, Marcia, Stefano, additional, Marini, Stefano, additional, Kelly, Stephen, additional, and Romão, Vasco, additional

Published
2023
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30. Sarilumab for Relapse of Polymyalgia Rheumatica during Glucocorticoid Taper

Author

Spiera, Robert F., primary, Unizony, Sebastian, additional, Warrington, Kenneth J., additional, Sloane, Jennifer, additional, Giannelou, Angeliki, additional, Nivens, Michael C., additional, Akinlade, Bolanle, additional, Wong, Wanling, additional, Bhore, Rafia, additional, Lin, Yong, additional, Buttgereit, Frank, additional, Devauchelle-Pensec, Valerie, additional, Rubbert-Roth, Andrea, additional, Yancopoulos, George D., additional, Marrache, Frederic, additional, Patel, Naimish, additional, and Dasgupta, Bhaskar, additional

Published
2023
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31. EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice: 2023 update

Author

Dejaco, Christian, primary, Ramiro, Sofia, additional, Bond, Milena, additional, Bosch, Philipp, additional, Ponte, Cristina, additional, Mackie, Sarah Louise, additional, Bley, Thorsten A, additional, Blockmans, Daniel, additional, Brolin, Sara, additional, Bolek, Ertugrul Cagri, additional, Cassie, Rebecca, additional, Cid, Maria C, additional, Molina-Collada, Juan, additional, Dasgupta, Bhaskar, additional, Nielsen, Berit Dalsgaard, additional, De Miguel, Eugenio, additional, Direskeneli, Haner, additional, Duftner, Christina, additional, Hočevar, Alojzija, additional, Molto, Anna, additional, Schäfer, Valentin Sebastian, additional, Seitz, Luca, additional, Slart, Riemer H J A, additional, and Schmidt, Wolfgang A, additional

Published
2023
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32. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Strand, Vibeke, primary, Jayne, David R W, additional, Horomanski, Audra, additional, Yue, Huibin, additional, Bekker, Pirow, additional, Merkel, Peter A, additional, Au Peh, Chen, additional, Chakera, Aron, additional, Cooper, Bruce, additional, Kurtkoti, Jagadeesh, additional, Langguth, Daman, additional, Levidiotis, Vicki, additional, Luxton, Grant, additional, Mount, Peter, additional, Mudge, David, additional, Noble, Euan, additional, Phoon, Richard, additional, Ranganathan, Dwarakanathan, additional, Ritchie, Angus, additional, Ryan, Jessica, additional, Suranyi, Michael, additional, Rosenkranz, Alexander, additional, Lhotta, Karl, additional, Kronbichler, Andreas, additional, Demoulin, Nathalie, additional, Bovy, Christophe, additional, Hellemans, Rachel, additional, Hougardy, Jean-Michel, additional, Sprangers, Ben, additional, Wissing, Karl Martin, additional, Pagnoux, Christian, additional, Barbour, Sean, additional, Brachemi, Soumeya, additional, Cournoyer, Serge, additional, Girard, Louis-Philippe, additional, Laurin, Louis-Philippe, additional, Liang, Patrick, additional, Philibert, David, additional, Walsh, Michael, additional, Tesar, Vladimir, additional, Becvar, Radim, additional, Horak, Pavel, additional, Rychlik, Ivan, additional, Szpirt, Wladimir, additional, Dieperink, Hans, additional, Gregersen, Jon Waarst, additional, Ivarsen, Per, additional, Krarup, Elizabeth, additional, Lyngsoe, Cecilie, additional, Rigothier, Claire, additional, Augusto, Jean-Francois, additional, Belot, Alexandre, additional, Chauveau, Dominique, additional, Cornec, Divi, additional, Jourde-Chiche, Noemie, additional, Ficheux, Maxence, additional, Karras, Alexandre, additional, Klein, Alexandre, additional, Maurier, Francois, additional, Mesbah, Rafik, additional, Moranne, Olivier, additional, Neel, Antoine, additional, Quemeneur, Thomas, additional, Saadoun, David, additional, Terrier, Benjamin, additional, Zaoui, Philippe, additional, Schaier, Matthias, additional, Benck, Urs Tobias, additional, Bergner, Raoul, additional, Busch, Martin, additional, Floege, Juergen, additional, Grundmann, Franziska, additional, Haller, Hermann, additional, Haubitz, Marion, additional, Hellmich, Bernhard, additional, Henes, Joerg Christoph, additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, Iking-Konert, Christof, additional, Arndt, Fabian, additional, Kubacki, T, additional, Kotter, Ina, additional, Lamprecht, Peter, additional, Lindner, Tom, additional, Halbritter, Jan, additional, Mehling, Heidrun, additional, Schönermarck, Ulf, additional, Venhoff, Nils, additional, Vielhauer, Volker, additional, Witzke, Oliver, additional, Szombati, Istvan, additional, Szucs, Gabriella, additional, Garibotto, Giacomo, additional, Alberici, Federico, additional, Brunetta, Enrico, additional, Dagna, Lorenzo, additional, De Vita, Salvatore, additional, Emmi, Giacomo, additional, Gabrielli, Armando, additional, Manenti, Lucio, additional, Pieruzzi, Federico, additional, Roccatello, Dario, additional, Salvarani, Carlo, additional, Harigai, Masayoshi, additional, Dobashi, Hiroaki, additional, Atsumi, Tatsuya, additional, Fujimoto, Shoichi, additional, Hagino, Noboru, additional, Ihata, Atsushi, additional, Kaname, Shinya, additional, Kaneko, Yuko, additional, Katagiri, Akira, additional, Katayama, Masao, additional, Kirino, Yohei, additional, Kitagawa, Kiyoki, additional, Komatsuda, Atsushi, additional, Kono, Hajime, additional, Kurasawa, Takahiko, additional, Matsumura, Ryutaro, additional, Mimura, Toshihide, additional, Morinobu, Akio, additional, Murakawa, Yohko, additional, Naniwa, Taio, additional, Nanki, Toshihiro, additional, Ogawa, Noriyoshi, additional, Oshima, Hisaji, additional, Sada, Kenei, additional, Sugiyama, Eiji, additional, Takeuchi, Tohru, additional, Taki, Hirofumi, additional, Tamura, Naoto, additional, Tsukamoto, Tatsuo, additional, Yamagata, Kunihiro, additional, Yamamura, Masahiro, additional, van Daele, Paulus Leon Arthur, additional, Rutgers, Abraham, additional, Teng, Y.K. Onno, additional, Walker, Robert, additional, Chua, Ignatius, additional, Collins, Michael, additional, Rabindranath, Kannaiyan, additional, de Zoysa, Janak, additional, Svensson, My Hanna Sofia, additional, Grevbo, Bard-Waldum, additional, Kalstad, Synove, additional, Little, Mark, additional, Clarkson, Michael, additional, Molloy, Eamonn, additional, Agraz Pamplona, Irene, additional, Anton, Jordi, additional, Barrio Lucia, Vicente, additional, Ciggaran, Secundino, additional, Cinta Cid, Maria, additional, Diaz Encarnacion, Montserrat, additional, Fulladosa Oliveras, Xavier, additional, Jose Soler, Maria, additional, Marco Rusinol, Helena, additional, Praga, Manuel, additional, Quintana Porras, Luis, additional, Segarra, Alfons, additional, Bruchfeld, Annette, additional, Segelmark, Marten, additional, Soveri, Inga, additional, Thomaidi, Eleni, additional, Westman, Kerstin, additional, Neumann, Thomas, additional, Burnier, Michel, additional, Daikeler, Thomas, additional, Dudler, Jean, additional, Hauser, Thomas, additional, Seeger, Harald, additional, Vogt, Bruno, additional, Burton, James, additional, Al Jayyousi, Reem, additional, Amin, Tania, additional, Andrews, Jacqueline, additional, Baines, Laura Anne, additional, Brogan, Paul, additional, Dasgupta, Bhaskar, additional, Doulton, Timothy William Ronald, additional, Flossmann, Oliver, additional, Griffin, Sian V., additional, Harper, Janice Marian, additional, Harper, Lorraine, additional, Kidder, Dana, additional, Klocke, Rainer, additional, Lanyon, Peter Charles, additional, Luqmani, Raashid, additional, McLaren, John Stuart, additional, Makanjuola, David Osagie, additional, McCann, Liza, additional, Nandagudi, Anupama C., additional, Selvan, Shilpa, additional, O'Riordan, Edmond, additional, Patel, Mumtaz, additional, Patel, Rajan Kantilal, additional, Pusey, Charles Dickson, additional, Rajakariar, Ravindra, additional, Robson, Joanna C., additional, Robson, Michael, additional, Salama, Alan David, additional, Smyth, Lucy, additional, Sznajd, Jan, additional, Taylor, Joanne, additional, Sreih, Antonie G., additional, Belilos, Elise, additional, Bomback, Andrew S., additional, Carlin, Jeffrey, additional, Chang Chen Lin, Yih, additional, Derebail, Vimal K., additional, Dragoi, Serban, additional, Dua, Anisha, additional, Forbess, Lindsy, additional, Geetha, Duvuru, additional, Gipson, Patrick, additional, Gohh, Reginald, additional, Greenwood, Gregory Todd, additional, Hugenberg, Steven T., additional, Jimenez, Richard A.H., additional, Kaskas, Marwan Omar, additional, Kermani, Tanaz, additional, Kivitz, Alan J., additional, Koening, Curry, additional, Langford, Carol A., additional, Marder, Galina, additional, Mohamed, Amr Ahmed El-Huesseini, additional, Monach, Paul, additional, Neyra, Nilda Roxana, additional, Niemer, Gregory W., additional, Niles, John, additional, Obi, Reginald, additional, Owens, Charles, additional, Parks, Deborah L., additional, Podoll, Amber S., additional, Rovin, Brad, additional, Sam, R, additional, Shergy, William Julius, additional, Silva, Arnold Lawrence, additional, Specks, Ulrich, additional, Spiera, Robert, additional, Springer, Jason M., additional, Striebich, Christopher Charles, additional, Swarup, Areena, additional, Thakar, Surabhi, additional, Tiliakos, Athan N., additional, Tsai, Yong, additional, Waguespack, Dia R., additional, and Chester Wasko, Mary, additional

Published
2023
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35. Early infection risk in patients with systemic lupus erythematosus treated with rituximab or belimumab from the British Isles Lupus Assessment Group Biologics Register (BILAG-BR): a prospective longitudinal study

Author

Rodziewicz, Mia, primary, Dyball, Sarah, additional, Lunt, Mark, additional, McDonald, Stephen, additional, Sutton, Emily, additional, Parker, Ben, additional, Bruce, Ian N, additional, Abernethy, Rikki, additional, Ahmad, Yasmeen, additional, Akil, Mohamed, additional, Bartram, Sarah, additional, Batley, Mike, additional, Bharadwaj, Anurag, additional, Bruce, Ian, additional, Carlucci, Francesco, additional, Chan, Antoni, additional, Dasgupta, Bhaskar, additional, D'Cruz, David, additional, De Lord, Denise, additional, Dyke, Bernard, additional, Edwards, Christopher, additional, Erb, Nicola, additional, Farrell, Adrian, additional, Gayed, Mary, additional, Gendi, Nagui, additional, Gompels, Luke, additional, Gordon, Caroline, additional, Gordon, Patrick, additional, Griffiths, Bridget, additional, Gullick, Nicola, additional, Gunwardena, Harsha, additional, Haigh, Richard, additional, Hamdulay, Shahir, additional, Haque, Sahena, additional, Hutchinson, David, additional, Isenberg, David, additional, Jayne, David, additional, Jeffery, Rachel, additional, Kapur, Deepti, additional, Kaul, Arvind, additional, King, Jon, additional, Knights, Sally, additional, Korendowych, Ellie, additional, Lanyon, Peter, additional, Mahindrakar, Madhu, additional, Marks, Jonathan, additional, McCann, Liza, additional, McLaren, Zoe, additional, Mediwake, Rapti, additional, Menon, Ajit, additional, Mewar, Devesh, additional, Min, Steven Young, additional, Nair, Jagdish, additional, O'Riordan, Edmond, additional, Pyne, Dev, additional, Rahmeh, Fouz, additional, Regan, Marian, additional, Reynolds, John, additional, Rhodes, Ben, additional, Rhys-Dillon, Ceril, additional, Robson, Joanna C, additional, Shaffu, Shireen, additional, Sheeran, T, additional, Skeoch, Sarah, additional, Sood, Bhrigu Raj, additional, Stratton, Richard, additional, Teh, Lee-Suan, additional, Vermaak, Erin, additional, Vital, Ed, additional, Waller, Rosemary, additional, Watts, Richard, additional, Wijeyekoon, Jananath, additional, Yee, Chee-Seng, additional, Yong, Cee Yi, additional, Youssef, Hazem, additional, Yusuf, Abid, additional, and Zoma, Asad, additional

Published
2023
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36. Identification of new risk loci and pathways involved in GCA pathogenesis by a genome-wide.

Author

Borrego Yaniz, Gonzalo, Ortiz-Fernández, Lourdes, Kerick, Martin, Madrid Paredes, Adela, Vaglio, Augusto, Hernández-Rodríguez, José, Mackie, Sarah, Castañeda, Santos, Solans-Laqué, Roser, Mestre, Jaume, Dasgupta, Bhaskar, Watts, Richard, Khalidi, Nader, Langford, Carol, Ytterberg, Steven R, Beretta, Lorenzo, Govoni, Marcelo, Emmi, Giacomo, Cimmino, Marco A., Witte, Torsten, Neumann, Thomas, Holle, Julia, Schönau, Verena, Pugnet, Gregory, Papo, Thomas, Haroche, Julien, Mahr, Alfred, Mouthon, Luc, Molberg, Oyvind, Diamantopoulos, Andreas P., Voskuyl, Alexandre E., Daikeler, Thomas, Berger, Christoph, Molloy, Eamonn, Blockmans, Daniel, Ortego-Centeno, Norberto, Brouwer, Elisabeth, Lamprecht, Peter, Klapa, Sebastian, Salvarani, Carlo, Merkel, Peter A., Cid, María C., González-Gay, M. A., Morgan, Ann, Martin Ibáñez, Javier, Márquez, Ana, Borrego Yaniz, Gonzalo, Ortiz-Fernández, Lourdes, Kerick, Martin, Madrid Paredes, Adela, Vaglio, Augusto, Hernández-Rodríguez, José, Mackie, Sarah, Castañeda, Santos, Solans-Laqué, Roser, Mestre, Jaume, Dasgupta, Bhaskar, Watts, Richard, Khalidi, Nader, Langford, Carol, Ytterberg, Steven R, Beretta, Lorenzo, Govoni, Marcelo, Emmi, Giacomo, Cimmino, Marco A., Witte, Torsten, Neumann, Thomas, Holle, Julia, Schönau, Verena, Pugnet, Gregory, Papo, Thomas, Haroche, Julien, Mahr, Alfred, Mouthon, Luc, Molberg, Oyvind, Diamantopoulos, Andreas P., Voskuyl, Alexandre E., Daikeler, Thomas, Berger, Christoph, Molloy, Eamonn, Blockmans, Daniel, Ortego-Centeno, Norberto, Brouwer, Elisabeth, Lamprecht, Peter, Klapa, Sebastian, Salvarani, Carlo, Merkel, Peter A., Cid, María C., González-Gay, M. A., Morgan, Ann, Martin Ibáñez, Javier, and Márquez, Ana

Published
2023

37. The provisional OMERACT ultrasonography score for giant cell arteritis

Author

Dejaco, Christian, Ponte, Cristina, Monti, Sara, Rozza, Davide, Scirè, Carlo Alberto, Terslev, Lene, Bruyn, George A.W., Boumans, Dennis, Hartung, Wolfgang, Hočevar, Alojzija, Milchert, Marcin, Døhn, Uffe Møller, Mukhtyar, Chetan B., Aschwanden, Markus, Bosch, Philipp, Camellino, Dario, Chrysidis, Stavros, Ciancio, Giovanni, D'Agostino, Maria Antonietta, Daikeler, Thomas, Dasgupta, Bhaskar, De Miguel, Eugenio, Diamantopoulos, Andreas P., Duftner, Christina, Agueda, Ana, Fredberg, Ulrich, Hanova, Petra, Hansen, Ib Tønder, Hauge, Ellen Margrethe, Iagnocco, Annamaria, Inanc, Nevsun, Juche, Aaron, Karalilova, Rositsa, Kawamoto, Toshio, Keller, Kresten Krarup, Keen, Helen Isobel, Kermani, Tanaz A., Kohler, Minna J., Koster, Matthew, Luqmani, Raashid Ahmed, MacChioni, Pierluigi, MacKie, Sarah Louise, Naredo, Esperanza, Nielsen, Berit Dalsgaard, Ogasawara, Michihiro, Pineda, Carlos, Schäfer, Valentin Sebastian, Seitz, Luca, Tomelleri, Alessandro, Torralba, Karina D., Van Der Geest, Kornelis S.M., Warrington, Kenneth J., Schmidt, Wolfgang A., Dejaco, Christian, Ponte, Cristina, Monti, Sara, Rozza, Davide, Scirè, Carlo Alberto, Terslev, Lene, Bruyn, George A.W., Boumans, Dennis, Hartung, Wolfgang, Hočevar, Alojzija, Milchert, Marcin, Døhn, Uffe Møller, Mukhtyar, Chetan B., Aschwanden, Markus, Bosch, Philipp, Camellino, Dario, Chrysidis, Stavros, Ciancio, Giovanni, D'Agostino, Maria Antonietta, Daikeler, Thomas, Dasgupta, Bhaskar, De Miguel, Eugenio, Diamantopoulos, Andreas P., Duftner, Christina, Agueda, Ana, Fredberg, Ulrich, Hanova, Petra, Hansen, Ib Tønder, Hauge, Ellen Margrethe, Iagnocco, Annamaria, Inanc, Nevsun, Juche, Aaron, Karalilova, Rositsa, Kawamoto, Toshio, Keller, Kresten Krarup, Keen, Helen Isobel, Kermani, Tanaz A., Kohler, Minna J., Koster, Matthew, Luqmani, Raashid Ahmed, MacChioni, Pierluigi, MacKie, Sarah Louise, Naredo, Esperanza, Nielsen, Berit Dalsgaard, Ogasawara, Michihiro, Pineda, Carlos, Schäfer, Valentin Sebastian, Seitz, Luca, Tomelleri, Alessandro, Torralba, Karina D., Van Der Geest, Kornelis S.M., Warrington, Kenneth J., and Schmidt, Wolfgang A.

Abstract

Objectives: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from-1.19 to-2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37-0.48). Conclusion: We developed a provisional OGUS for potential use in clinical trials.

Published
2023

38. Towards a Comprehensive Index of Labour Law Reform and Ranking of States

Author

Dasgupta, Bhaskar

Abstract

Since the pioneering paper by Besley and Burgess (2004)claimed to have found a positive relationship between flexible and pro-employer labour regulations with manufacturing sector performance, there has been an increasing pitch among policymakers to rationalise India’s complicated labour laws. Several state governments have since undertaken significant reforms in their respective labour law regimes. During the recent pandemic-induced lockdown, some states have gone to the extent of temporarily suspending labour laws to kick-start the economy. The Government of India has also recently consolidated the fragmented labour laws by integrating them into four functionally arranged Codes. But the regulatory measure developed by Besley and Burgess, the very basis of their conclusions, has been criticised on the ground of narrow coverage, methodological inconsistency, misclassification of amendments, etc. This article, therefore, attempts to construct a comprehensive Index by mapping state level-amendments in five important labour legislations over the seven-decade period from 1949 to 2017 and coding those amendments. The article is organised as follows: After the context-setting introductory section, the second section summarises the existing evidence on the relationship between labour regulations and manufacturing sector performance in India. The third section discusses the limitations of Besley–Burgess Index. The fourth section briefly mentions the research direction post publication of Besley–Burgess paper. The fifth section develops a comprehensive Index, and it discusses how it improves the BB Index. The sixth section concludes the article.JEL:J3, K3

Published
2023
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39. Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil.

Author

Akthar, Mumina, Nair, Nisha, Carter, Lucy M., Vital, Edward M., Sutton, Emily, McHugh, Neil, Gordon, Patrick, Young-Min, Steven, Stevens, Robert, Prabu, Athiveer, Batley, Mike, Gendi, Nagui, Dasgupta, Bhaskar, Khamashta, Munther, Hewins, Peter, Stratton, Richard J., Chan, Antoni, De Lord, Denise, King, Jon, and Dubey, Shirish

Published
2023
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40. Treat-to-target recommendations in giant cell arteritis and polymyalgia rheumatica

Author

Dejaco, Christian, primary, Kerschbaumer, Andreas, additional, Aletaha, Daniel, additional, Bond, Milena, additional, Hysa, Elvis, additional, Camellino, Dario, additional, Ehlers, Lisa, additional, Abril, Andy, additional, Appenzeller, Simone, additional, Cid, Maria C, additional, Dasgupta, Bhaskar, additional, Duftner, Christina, additional, Grayson, Peter C, additional, Hellmich, Bernhard, additional, Hočevar, Alojzija, additional, Kermani, Tanaz A, additional, Matteson, Eric L, additional, Mollan, Susan P, additional, Neill, Lorna, additional, Ponte, Cristina, additional, Salvarani, Carlo, additional, Sattui, Sebastian Eduardo, additional, Schmidt, Wolfgang A, additional, Seo, Philip, additional, Smolen, Josef S, additional, Thiel, Jens, additional, Toro-Gutiérrez, Carlos Enrique, additional, Whitlock, Madeline, additional, and Buttgereit, Frank, additional

Published
2023
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41. An international survey of current management practices for polymyalgia rheumatica by general practitioners and rheumatologists

Author

Donskov, Agnete Overgaard, primary, Mackie, Sarah Louise, additional, Hauge, Ellen Margrethe, additional, Toro-Gutiérrez, Carlos Enrique, additional, Hansen, Ib Tønder, additional, Hemmig, Andrea Katharina, additional, Van der Maas, Aatke, additional, Gheita, Tamer, additional, Nielsen, Berit Dalsgaard, additional, Douglas, Karen M J, additional, Conway, Richard, additional, Rezus, Elena, additional, Dasgupta, Bhaskar, additional, Monti, Sara, additional, Matteson, Eric L, additional, Sattui, Sebastian E, additional, Matza, Mark, additional, Ocampo, Vanessa, additional, Gromova, Margarita, additional, Grainger, Rebecca, additional, Bran, Andrea, additional, Appenzeller, Simone, additional, Goecke, Annelise, additional, Colman, Nelly, additional, Keen, Helen I, additional, Kuwana, Masataka, additional, Gupta, Latika, additional, Salim, Babur, additional, Harifi, Ghita, additional, Erraoui, Mariam, additional, Ziade, Nelly, additional, Al-Ani, Nizar Abdulateef, additional, Ajibade, Adeola, additional, Knitza, Johannes, additional, Frølund, Line, additional, Yates, Max, additional, Pimentel-Quiroz, Victor R, additional, Lyrio, Andre Marun, additional, Sandovici, Maria, additional, Van der Geest, Kornelis S M, additional, Helliwell, Toby, additional, Brouwer, Elisabeth, additional, Dejaco, Christian, additional, and Keller, Kresten Krarup, additional

Published
2023
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42. The provisional OMERACT ultrasonography score for giant cell arteritis

Author

Dejaco, Christian, primary, Ponte, Cristina, additional, Monti, Sara, additional, Rozza, Davide, additional, Scirè, Carlo Alberto, additional, Terslev, Lene, additional, Bruyn, George A W, additional, Boumans, Dennis, additional, Hartung, Wolfgang, additional, Hočevar, Alojzija, additional, Milchert, Marcin, additional, Døhn, Uffe Møller, additional, Mukhtyar, Chetan B, additional, Aschwanden, Markus, additional, Bosch, Philipp, additional, Camellino, Dario, additional, Chrysidis, Stavros, additional, Ciancio, Giovanni, additional, D’Agostino, Maria Antonietta, additional, Daikeler, Thomas, additional, Dasgupta, Bhaskar, additional, De Miguel, Eugenio, additional, Diamantopoulos, Andreas P, additional, Duftner, Christina, additional, Agueda, Ana, additional, Fredberg, Ulrich, additional, Hanova, Petra, additional, Hansen, Ib Tønder, additional, Hauge, Ellen-Margrethe, additional, Iagnocco, Annamaria, additional, Inanc, Nevsun, additional, Juche, Aaron, additional, Karalilova, Rositsa, additional, Kawamoto, Toshio, additional, Keller, Kresten Krarup, additional, Keen, Helen Isobel, additional, Kermani, Tanaz A, additional, Kohler, Minna J., additional, Koster, Matthew, additional, Luqmani, Raashid Ahmed, additional, Macchioni, Pierluigi, additional, Mackie, Sarah Louise, additional, Naredo, Esperanza, additional, Nielsen, Berit Dalsgaard, additional, Ogasawara, Michihiro, additional, Pineda, Carlos, additional, Schäfer, Valentin Sebastian, additional, Seitz, Luca, additional, Tomelleri, Alessandro, additional, Torralba, Karina D, additional, van der Geest, Kornelis S M, additional, Warrington, Kenneth J, additional, and Schmidt, Wolfgang A, additional

Published
2022
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45. Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil.

Author

Akhtar, Mumina, Nair, Nisha, Carter, Lucy M., Vital, Edward M., Sutton, Emily, McHugh, Neil, British Isles Lupus Assessment Group Biologics Register (BILAG BR) Consortium, Gordon, Patrick, Young-Min, Steven, Stevens, Robert, Prabu, Athiveer, Batley, Mike, Gendi, Nagui, Dasgupta, Bhaskar, Khamashta, Munther, Hewins, Peter, Stratton, Richard J., Chan, Antoni, De Lord, Denise, and King, Jon

Published
2023
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46. A hybrid approach to study large conformational transitions of biomolecules from single particle XFEL diffraction data

Author

Asi, Han, Dasgupta, Bhaskar, Nagai, Tetsuro, Miyashita, Osamu, and Tama, Florence

Subjects
Biochemistry, Genetics and Molecular Biology (miscellaneous), Molecular Biology, Biochemistry
Abstract

X-ray free-electron laser (XFEL) is the latest generation of the X-ray source that could become an invaluable technique in structural biology. XFEL has ultrashort pulse duration, extreme peak brilliance, and high spatial coherence, which could enable the observation of the biological molecules in near nature state at room temperature without crystallization. However, for biological systems, due to their low diffraction power and complexity of sample delivery, experiments and data analysis are not straightforward, making it extremely challenging to reconstruct three-dimensional (3D) structures from single particle XFEL data. Given the current limitations to the amount and resolution of the data from such XFEL experiments, we propose a new hybrid approach for characterizing biomolecular conformational transitions by using a single 2D low-resolution XFEL diffraction pattern in combination with another known conformation. In our method, we represent the molecular structure with a coarse-grained model, the Gaussian mixture model, to describe large conformational transitions from low-resolution XFEL data. We obtain plausible 3D structural models that are consistent with the XFEL diffraction pattern by deforming an initial structural model to maximize the similarity between the target pattern and the simulated diffraction patterns from the candidate models. We tested the proposed algorithm on two biomolecules of different sizes with different complexities of conformational transitions, adenylate kinase, and elongation factor 2, using synthetic XFEL data. The results show that, with the proposed algorithm, we can successfully describe the conformational transitions by flexibly fitting the coarse-grained model of one conformation to become consistent with an XFEL diffraction pattern simulated from another conformation. In addition, we showed that the incident beam orientation has some effect on the accuracy of the 3D structure modeling and discussed the reasons for the inaccuracies for certain orientations. The proposed method could serve as an alternative approach for retrieving information on 3D conformational transitions from the XFEL diffraction patterns to interpret experimental data. Since the molecules are represented by Gaussian kernels and no atomic structure is needed in principle, such a method could also be used as a tool to seek initial models for 3D reconstruction algorithms.

Published
2022

48. Contribution of pathogenic T helper 1 and 17 cells to bursitis and tenosynovitis in polymyalgia rheumatica

Author

Reitsema, Rosanne D., primary, Jiemy, William F., additional, Wekema, Lieske, additional, Boots, Annemieke M. H., additional, Heeringa, Peter, additional, Huitema, Minke G., additional, Abdulahad, Wayel H., additional, van Sleen, Yannick, additional, Sandovici, Maria, additional, Roozendaal, Caroline, additional, Diepstra, Arjan, additional, Kwee, Thomas, additional, Dasgupta, Bhaskar, additional, Brouwer, Elisabeth, additional, and van der Geest, Kornelis S. M., additional

Published
2022
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50. The provisional OMERACT ultrasonography score for giant cell arteritis

Author

Dejaco, Christian, Ponte, Cristina, Monti, Sara, Rozza, Davide, Scirè, Carlo Alberto, Terslev, Lene, Bruyn, George A W, Boumans, Denni, Hartung, Wolfgang, Hočevar, Alojzija, Milchert, Marcin, Døhn, Uffe Møller, Mukhtyar, Chetan B, Aschwanden, Marku, Bosch, Philipp, Camellino, Dario, Chrysidis, Stavro, Ciancio, Giovanni, D'Agostino, Maria Antonietta, Daikeler, Thoma, Dasgupta, Bhaskar, De Miguel, Eugenio, Diamantopoulos, Andreas P, Duftner, Christina, Agueda, Ana, Fredberg, Ulrich, Hanova, Petra, Hansen, Ib Tønder, Hauge, Ellen-Margrethe, Iagnocco, Annamaria, Inanc, Nevsun, Juche, Aaron, Karalilova, Rositsa, Kawamoto, Toshio, Keller, Kresten Krarup, Keen, Helen Isobel, Kermani, Tanaz A, Kohler, Minna J, Koster, Matthew, Luqmani, Raashid Ahmed, Macchioni, Pierluigi, Mackie, Sarah Louise, Naredo, Esperanza, Nielsen, Berit Dalsgaard, Ogasawara, Michihiro, Pineda, Carlo, Schäfer, Valentin Sebastian, Seitz, Luca, Tomelleri, Alessandro, Torralba, Karina D, van der Geest, Kornelis S M, Warrington, Kenneth J, Schmidt, Wolfgang A, D'Agostino, Maria Antonietta (ORCID:0000-0002-5347-0060), Dejaco, Christian, Ponte, Cristina, Monti, Sara, Rozza, Davide, Scirè, Carlo Alberto, Terslev, Lene, Bruyn, George A W, Boumans, Denni, Hartung, Wolfgang, Hočevar, Alojzija, Milchert, Marcin, Døhn, Uffe Møller, Mukhtyar, Chetan B, Aschwanden, Marku, Bosch, Philipp, Camellino, Dario, Chrysidis, Stavro, Ciancio, Giovanni, D'Agostino, Maria Antonietta, Daikeler, Thoma, Dasgupta, Bhaskar, De Miguel, Eugenio, Diamantopoulos, Andreas P, Duftner, Christina, Agueda, Ana, Fredberg, Ulrich, Hanova, Petra, Hansen, Ib Tønder, Hauge, Ellen-Margrethe, Iagnocco, Annamaria, Inanc, Nevsun, Juche, Aaron, Karalilova, Rositsa, Kawamoto, Toshio, Keller, Kresten Krarup, Keen, Helen Isobel, Kermani, Tanaz A, Kohler, Minna J, Koster, Matthew, Luqmani, Raashid Ahmed, Macchioni, Pierluigi, Mackie, Sarah Louise, Naredo, Esperanza, Nielsen, Berit Dalsgaard, Ogasawara, Michihiro, Pineda, Carlo, Schäfer, Valentin Sebastian, Seitz, Luca, Tomelleri, Alessandro, Torralba, Karina D, van der Geest, Kornelis S M, Warrington, Kenneth J, Schmidt, Wolfgang A, and D'Agostino, Maria Antonietta (ORCID:0000-0002-5347-0060)

Abstract

Objectives: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37-0.48). Conclusion: We developed a provisional OGUS for potential use in clinical trials.

Published
2022

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