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Your search keyword '"Dagny Von Ahrens"' showing total 6 results
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6 results on '"Dagny Von Ahrens"'

1. The Impact of Metabolic Health and Obesity on Liver Transplant Candidates and Recipients

Author

Alexander S. Vogel, Rebecca Roediger, Dagny von Ahrens, Brett E. Fortune, Jonathan M. Schwartz, Shalom Frager, Kristina R. Chacko, and Clara Y. Tow

Subjects
metabolic dysfunction, fatty liver, liver transplantation, steatotic liver disease, Science
Abstract

Poor metabolic health and obesity have significant impacts on the outcomes of patients suffering from chronic liver disease, particularly those with metabolic dysfunction-associated steatotic liver disease. Patients with such comorbidities who require liver transplant evaluation for advancing liver disease or liver failure require special consideration due to increased risk of cardiovascular disease, renal dysfunction, sarcopenic obesity, and cancer. Those who have had a history of prior bariatric surgery pose specific anatomical constraints and may also be at increased risk of alcohol use disorder. Pre-operative risk assessment as well as strict control of metabolic risk factors are essential to reduce intra-operative and post-liver transplant complications. As immunosuppressive therapy exacerbates metabolic dysfunction and risk for cancer, post-liver transplant care must focus on balancing the need to prevent rejection and the impact of progressive metabolic dysfunction in this unique, but growing, patient population.

Published
2024
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2. Supp tables 1-5 from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Author

Amit Verma, Michael G. Kharas, H. Joachim Deeg, Marc H.G.P. Raaijmakers, Ulrich Steidl, Britta Will, Jacqueline Boultwood, Andrea Pellagatti, Siddhartha Mukherjee, John M. Greally, Jinghang Zhang, Kith Pradhan, Yiting Yu, Konrad Hochedlinger, Peter Aplan, Kira Gritsman, Cecilia Yeung, Amittha Wickrema, Davendra Sohal, Orsi Giricz, Prafulla Bhagat, Robert Lopez, Remi Laurence, Vineeth Sukrithan, Iaonnis Mantzaris, Nandini Ramachandra, Suman Kambhampati, Remco M. Hoogenboezem, Mathijs A. Sanders, A. Mario Marcondes, Elianna Amin, Patrick Tivnan, Gaurav S. Choudhary, Dagny Von Ahrens, A. Trevor Barlowe, Matthias Bartenstein, Si Chen, and Tushar D. Bhagat

Abstract

Supp Table 1: MDS Patient Disease Characteristics Supp Table 2: Pathways affected by hypermethylation in MDS stroma Supp Table 3: Genes that are methylated and underexpressed in MDS stroma Supp Table 4. MDS patient characteristics for primary MSC sample isolation Supp table 5: WNT Targets

Published
2023

3. Supp Methods from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Author

Amit Verma, Michael G. Kharas, H. Joachim Deeg, Marc H.G.P. Raaijmakers, Ulrich Steidl, Britta Will, Jacqueline Boultwood, Andrea Pellagatti, Siddhartha Mukherjee, John M. Greally, Jinghang Zhang, Kith Pradhan, Yiting Yu, Konrad Hochedlinger, Peter Aplan, Kira Gritsman, Cecilia Yeung, Amittha Wickrema, Davendra Sohal, Orsi Giricz, Prafulla Bhagat, Robert Lopez, Remi Laurence, Vineeth Sukrithan, Iaonnis Mantzaris, Nandini Ramachandra, Suman Kambhampati, Remco M. Hoogenboezem, Mathijs A. Sanders, A. Mario Marcondes, Elianna Amin, Patrick Tivnan, Gaurav S. Choudhary, Dagny Von Ahrens, A. Trevor Barlowe, Matthias Bartenstein, Si Chen, and Tushar D. Bhagat

Abstract

Supplementary Methods

Published
2023

4. Data from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Author

Amit Verma, Michael G. Kharas, H. Joachim Deeg, Marc H.G.P. Raaijmakers, Ulrich Steidl, Britta Will, Jacqueline Boultwood, Andrea Pellagatti, Siddhartha Mukherjee, John M. Greally, Jinghang Zhang, Kith Pradhan, Yiting Yu, Konrad Hochedlinger, Peter Aplan, Kira Gritsman, Cecilia Yeung, Amittha Wickrema, Davendra Sohal, Orsi Giricz, Prafulla Bhagat, Robert Lopez, Remi Laurence, Vineeth Sukrithan, Iaonnis Mantzaris, Nandini Ramachandra, Suman Kambhampati, Remco M. Hoogenboezem, Mathijs A. Sanders, A. Mario Marcondes, Elianna Amin, Patrick Tivnan, Gaurav S. Choudhary, Dagny Von Ahrens, A. Trevor Barlowe, Matthias Bartenstein, Si Chen, and Tushar D. Bhagat

Abstract

The bone marrow microenvironment influences malignant hematopoiesis, but how it promotes leukemogenesis has not been elucidated. In addition, the role of the bone marrow stroma in regulating clinical responses to DNA methyltransferase inhibitors (DNMTi) is also poorly understood. In this study, we conducted a DNA methylome analysis of bone marrow–derived stromal cells from myelodysplastic syndrome (MDS) patients and observed widespread aberrant cytosine hypermethylation occurring preferentially outside CpG islands. Stroma derived from 5-azacytidine–treated patients lacked aberrant methylation and DNMTi treatment of primary MDS stroma enhanced its ability to support erythroid differentiation. An integrative expression analysis revealed that the WNT pathway antagonist FRZB was aberrantly hypermethylated and underexpressed in MDS stroma. This result was confirmed in an independent set of sorted, primary MDS-derived mesenchymal cells. We documented a WNT/β-catenin activation signature in CD34+ cells from advanced cases of MDS, where it associated with adverse prognosis. Constitutive activation of β-catenin in hematopoietic cells yielded lethal myeloid disease in a NUP98–HOXD13 mouse model of MDS, confirming its role in disease progression. Our results define novel epigenetic changes in the bone marrow microenvironment, which lead to β-catenin activation and disease progression of MDS. Cancer Res; 77(18); 4846–57. ©2017 AACR.

Published
2023

5. Supp Figs 1-5 from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Author

Amit Verma, Michael G. Kharas, H. Joachim Deeg, Marc H.G.P. Raaijmakers, Ulrich Steidl, Britta Will, Jacqueline Boultwood, Andrea Pellagatti, Siddhartha Mukherjee, John M. Greally, Jinghang Zhang, Kith Pradhan, Yiting Yu, Konrad Hochedlinger, Peter Aplan, Kira Gritsman, Cecilia Yeung, Amittha Wickrema, Davendra Sohal, Orsi Giricz, Prafulla Bhagat, Robert Lopez, Remi Laurence, Vineeth Sukrithan, Iaonnis Mantzaris, Nandini Ramachandra, Suman Kambhampati, Remco M. Hoogenboezem, Mathijs A. Sanders, A. Mario Marcondes, Elianna Amin, Patrick Tivnan, Gaurav S. Choudhary, Dagny Von Ahrens, A. Trevor Barlowe, Matthias Bartenstein, Si Chen, and Tushar D. Bhagat

Abstract

Supp Fig 1 : SFRP1 methylation with coculture Supp Fig 2 : Validation of methylation changes with stroma and leukemic cell coculture Supp Fig 3: FRZB upregulation in MDS stroma after 5-Azacytidine treatment SuppFig 4: FRZB knockdown leads to partial inhibition of erythroid differentiation induced by treatment of MDS stromawith 5-Aza SuppFig 5: The expression of WNT signature genes in MDS and control marrow derived CD34+ cells

Published
2023

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