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Your search keyword '"DIIODOMETHANE"' showing total 2 results
Start Over Descriptor "DIIODOMETHANE" Publication Year Range Last 3 years
2 results on '"DIIODOMETHANE"'

1. Design, synthesis of bisbenzimidazole dithiol derivatives and analogs

Author

Kouassi Yves Guillaume MOLOU, Tchambaga Etienne CAMARA, Adeyolé TIMOTOU, Souleymane COULIBALY, Aka Faustin KABRAN, Siomenan COULIBALI, and Drissa SISSOUMA

Subjects
Benzimidazole, Dithiol, Oxidation, Diiodomethane, Analogs, General Medicine
Abstract

The benzimidazole scaffold is an important pharmacophore and one of the preferred structures in medicinal chemistry due to the wide range of biological activities of its derivatives. Here in this article, the synthesis of two series of compounds, namely bis(thiobenzimidazol-2-yl)methane derivatives and analogs (4a-e) and bis(benzimidazol-2-yl)dithiol derivatives and analogs (5a-e) are described. These compounds were synthesized by first designing 2-mercaptobenzimidazole derivatives and analogs (2a-e) by action of orthophenylenediamine and analogs (1a-e) with carbon disulfide. Reaction of thiols (2a-e) with diiodomethane leads to bis(thiobenzimidazol-2-yl)methane derivatives and analogs (4a-e). Their treatment in glacial acetic acid led to their oxidation to bis(benzimidazol-2-yl)dithiol derivatives and analogs (5a-e). The structures of the synthesized compounds were characterized by 1H, 13C Nuclear Magnetic Resonance (NMR), and High-Resolution Mass Spectrometry (HRMS) analyses.

Published
2022
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2. Critical assessment of the correlation between surface tension components and Hansen solubility parameters.

Author

Kusano, Yukihiro and Kusano, Reinosuke

Subjects
*SOLUBILITY, *SURFACE phenomenon, *SURFACE tension, *INDUSTRIAL engineering, *ADSORPTION (Chemistry)
Abstract

Surface or interfacial phenomena, including wetting, adsorption, adhesion, and dissolution, are of significant interest for daily life as well as for industrial and engineering applications. Surface tension and the Hansen solubility parameter (HSP) both represent similar physical characteristics related to these phenomena. It is therefore interesting to study the relation between them, and in the present work, reported empirical relations between surface tension and HSP are critically investigated. There exists an approximately proportional relation between total surface tension and HSP, although the coefficient obtained in the present work is much smaller than the commonly reported ones. The result is supported by an estimation of the coefficient using a simple physical model. On the other hand, finding correlations between the partial components of surface tension and HSP appears to be difficult as they are measured differently. The uses of databases from which measurements are taken must also be taken into question. As an example, the surface tension components of diiodomethane are investigated, and the validity of the reported values are called into question. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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