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Your search keyword '"Díez-Pascual, Ana"' showing total 324 results
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324 results on '"Díez-Pascual, Ana"'

10. Two-Dimensional Graphitic Carbon Nitride (g-C3N4) Nanosheets and Their Derivatives for Diagnosis and Detection Applications

Author

Pourmadadi, Mehrab, Rajabzadeh-Khosroshahi, Maryam, Saeidi Tabar, Fatemeh, Ajalli, Narges, Samadi, Amirmasoud, Yazdani, Mahsa, Yazdian, Fatemeh, Rahdar, Abbas, and Díez-Pascual, Ana M

Subjects
Engineering, Nanotechnology, Biomedical Engineering, Bioengineering, Prevention, diagnosis, graphitic carbon nitride, biosensors, nanomaterials, antimicrobial activity biomedical applications, Medical Biotechnology, Biomedical engineering
Abstract

The early diagnosis of certain fatal diseases is vital for preventing severe consequences and contributes to a more effective treatment. Despite numerous conventional methods to realize this goal, employing nanobiosensors is a novel approach that provides a fast and precise detection. Recently, nanomaterials have been widely applied as biosensors with distinctive features. Graphite phase carbon nitride (g-C3N4) is a two-dimensional (2D) carbon-based nanostructure that has received attention in biosensing. Biocompatibility, biodegradability, semiconductivity, high photoluminescence yield, low-cost synthesis, easy production process, antimicrobial activity, and high stability are prominent properties that have rendered g-C3N4 a promising candidate to be used in electrochemical, optical, and other kinds of biosensors. This review presents the g-C3N4 unique features, synthesis methods, and g-C3N4-based nanomaterials. In addition, recent relevant studies on using g-C3N4 in biosensors in regard to improving treatment pathways are reviewed.

Published
2022

45. Controlled curcumin delivery via carboxymethyl starch‐modified gamma alumina nanoparticles in a polyethylene glycol‐based hydrogel.

Author

Adeli, Fatemeh, Pourmadadi, Mehrab, Abdouss, Majid, Rahdar, Abbas, Fathi‐karkan, Sonia, Samandari, Saeed Saber, and Díez‐Pascual, Ana M.

Subjects
FIELD emission electron microscopy, SURFACE charges, WOOD products, POLYETHYLENE glycol, LIGHT scattering, CARBOXYMETHYL compounds
Abstract

One of the most prevalent cancers affecting women globally is breast cancer. Consequently, the development of cost‐effective and low‐risk treatment options remains a critical pursuit. This study describes the synthesis via water‐in‐oil‐in‐water (W/O/W) of a pH‐responsive nanocarrier for curcumin delivery, a promising anticancer drug. The nanocarrier comprises carboxymethyl starch (CMS), polyethylene glycol (PEG), and gamma alumina (γ‐Al2O3) nanoparticles. The molecular interactions between the nanocomposite components, its crystalline structure, surface morphology, size distribution, and surface charge were assessed via Fourier‐transformed infrared (FTIR) spectroscopy, field emission‐scanning electron microscopy (FE‐SEM), x‐ray diffraction (XRD), dynamic light scattering (DLS) and zeta potential, respectively. The nanocarrier showed a size ranging from 150 to 280 nm, zeta potential of +35.4 mV, drug loading of 47% and an encapsulation efficiency of 87%, which are among the maximum values reported to date for curcumin nanocarriers. A gradual drug release was observed, with 51% and 90% released after 72 h at pH 7.4 and 5.4, respectively, which corroborates the pH‐sensitivity of the nanocarrier. The cytotoxic effects of the curcumin‐loaded nanocomposite on MCF‐7 breast cancer cells and normal cells were investigated using methylthiazolyldiphenyl‐tetrazolium bromide (MTT) assay and flow cytometry. The results demonstrated that loading curcumin onto the hydrogel significantly enhances its penetration into MCF‐7 cells. Overall, this novel nanocomposite offers a promising approach for curcumin delivery in breast cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Corrigendum to “Electrochemical nanobiosensor based on reduced graphene oxide and gold nanoparticles for ultrasensitive detection of microRNA-128” [Int. J. Immunopharmacol. 117 (2023) 109960]

Author

Mohammadnejad, Javad, primary, Basirhaghighi, Niki, additional, Yazdian, Fatemeh, additional, Pourmadadi, Mehrab, additional, shayeh, Javad Shabani, additional, Omidi, Meisam, additional, Mirshafiei, Mojdeh, additional, Rahdar, Abbas, additional, and Díez-Pascual, Ana M., additional

Published
2024
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