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1. Consensus classification of pediatric hepatocellular tumors: A report from the Children's Hepatic tumors International Collaboration (CHIC)

Author

Cho, Soo‐Jin, Ranganathan, Sarangarajan, Alaggio, Rita, Maibach, Rudolf, Tanaka, Yukichi, Inoue, Takeshi, Leuschner, Ivo, Krijger, Ronald, Vokuhl, Christian, Krailo, Mark, Malogolowkin, Marcio, Meyers, Rebecka, Czauderna, Piotr, Hiyama, Eiso, Ansari, Marc, Morland, Bruce, Trobaugh‐Lotrario, Angela, O'Neill, Allison F, Rangaswami, Arun, Häberle, Beate, and López‐Terrada, Dolores

Subjects
Liver Disease, Pediatric, Digestive Diseases, Rare Diseases, Cancer, hepatoblastoma, international clinical trial, liver tumors, pediatric, Clinical Sciences, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis
Abstract

BackgroundLiver tumors are rare in children with histologic heterogeneity that makes diagnosis challenging. Systematic histopathological review, performed as part of collaborative therapeutic protocols, identified relevant histologic subtypes that are important to distinguish. The Children's Hepatic tumors International Collaboration (CHIC) was established to study pediatric liver tumors on a global scale and led to establishment of a provisional consensus classification for use in international clinical trials. The current study is the validation of this initial classification and first large-scale application by international expert reviewers.ProcedureThe CHIC initiative includes data from 1605 children treated on eight multicenter hepatoblastoma (HB) trials. Review of 605 available tumors was performed by seven expert pathologists from three consortia (US, EU, Japan). Cases with discordant diagnoses were collectively reviewed to reach a final consensus diagnosis.ResultsOf 599 cases with sufficient material for review, 570 (95.2%) were classified as HB by all consortia, and 29 (4.8%) as non-HB, which included "hepatocellular neoplasm, NOS" and malignant rhabdoid tumors. 453 of 570 HBs were classified as epithelial by final consensus. Some patterns (i.e., small cell undifferentiated, macrotrabecular, cholangioblastic) were selectively identified by reviewers from different consortia. All consortia identified a similar number of mixed epithelial-mesenchymal HB.ConclusionsThis study represents the first large-scale application and validation of the pediatric malignant hepatocellular tumors consensus classification. It is a valuable resource to train future generations of investigators on accurate diagnosis of these rare tumors and provides a framework for further international collaborative studies and refinement of the current classification of pediatric liver tumors.

Published
2023

2. Outcomes of Patients Treated for Hepatoblastoma with Low Alpha-Fetoprotein and/or Small Cell Undifferentiated Histology: A Report from the Children's Hepatic Tumors International Collaboration (CHIC).

Author

Trobaugh-Lotrario, Angela D, Maibach, Rudolf, Aronson, Daniel C, Rangaswami, Arun, Häberle, Beate, O'Neill, Allison F, Schmid, Irene, Ansari, Marc, Hishiki, Tomoro, Ranganathan, Sarangarajan, Alaggio, Rita, de Krijger, Ronald R, Tanaka, Yukichi, Cho, Soo-Jin, Vokuhl, Christian, Maxwell, Rebecca, Krailo, Mark, Hiyama, Eiso, Czauderna, Piotr, Finegold, Milton, Feusner, James H, Malogolowkin, Marcio H, Meyers, Rebecka L, and Lopez-Terrada, Dolores

Subjects
AFP, Hepatoblastoma, SCU, SMARCB1, rhabdoid, Cancer, Digestive Diseases, Liver Disease, Oncology and Carcinogenesis
Abstract

Small cell undifferentiated (SCU) histology and alpha-fetoprotein (AFP) levels below 100 ng/mL have been reported as poor prognostic factors in hepatoblastoma (HB); subsequent studies reported SMARCB1 mutations in some SCU HBs confirming the diagnosis of rhabdoid tumor. The Children's Hepatic tumors International Collaboration (CHIC) database was queried for patients with HB who had AFP levels less than 100 ng/mL at diagnosis or were historically diagnosed as SCU HBs. Seventy-three of 1605 patients in the CHIC database were originally identified as SCU HB, HB with SCU component, or HB with low AFP levels. Upon retrospective review, they were re-classified as rhabdoid tumors (n = 11), HB with SCU component (n = 41), and HB with low AFP (n = 14). Seven were excluded for erroneously low AFP levels. Overall survival was 0% for patients with rhabdoid tumors, 76% for patients with HB with SCU component, and 64% for patients with HB with AFP less than 100 ng/mL. Patients with HB with SCU component or low AFP should be assessed for SMARCB1 mutations and, if confirmed, treated as rhabdoid tumors. When rhabdoid tumors are excluded, the presence of SCU component and low AFP at diagnosis were not associated with poor prognosis in patients diagnosed with HB.

Published
2023

3. Retrospective comparative analysis of two medical evacuation systems for Ukrainian patients affected by war

Author

Adyrov, Mykhaylo V, Alanbousi, Inna, Alexander, Sarah Weeks, Apel, Anna, Avula, Meghana, Bal, Wioletta Anna, Balwierz, Walentyna Aniela, Basset-Salom, Luisa, Bastardo Blanco, Daniel, Bauer, Karolina Jadwiga, Bayazitov, Ildar T, Berlanga, Pablo, Bhakta, Nickhill Hitesh, Bieniek, Katarzyna Anna, Bien, Ewa Iwona, Blackwood, Christopher Andrew, Blair, Sally Jane, Bodak, Khrystyna Ihorivna, Bordeianu, Irina, Bouffet, Eric Eric, Braganca, Joao Maria, Bucurenci, Mihaela Silvia, Budny, Elżbieta Beata, Budzyn, Andrii, Bumgardner, Christopher Carl, Burditt, Raina Nichole, Burnside Clapp, Victoria, Bykov, Viacheslav Valeriyovych, Cañete, Adela, Carnelli, Monica, Cela, Elena, Cepowska, Zuzanna, Chaber, Radoslaw, Cherner-Drieux, Anna, Chubata, Mariya, Clough, Heidi M, Czauderna, Piotr Stefan, Czernicka - Siwecka, Jolanta, Czyzewski, Krzysztof, Dalle, Jean-Hugues, Dashchakovska, Olha, de Koning, Linda A, Dembowska-Baginska, Bozenna Malgorzata, Derwich, Katarzyna, Dirksen, Uta, Dommett, Rachel, Dorosh, Olha Ihorivna, dos Reis Farinha, Nuno Jorge, Drabko, Katarzyna Anna, Dragomir, Monica Desiree, Dutkiewicz, Malgorzata, Dworzak, Michael, Dyma, Sergii Vitaliiovych, Earl, Julian, Eggert, Angelika, English, Martin William, Farren, Becky S, Fedyk, Nataliia Yuriina, Fernández-Teijeiro, Ana, Ferneza, Severyn Romanovych, Foster, Whitney Baer, Fox Irwin, Leeanna Elizabeth, Gałązkowski, Robert Maciej, Ganieva, Galyna, Garanzha, Vasylyna Andriivna, Gelman, Marina S, Godzinski, Jan Krzysztof, Goeres, Anne Françoise, Golban, Rodica, Graetz, Dylan Elizabeth, Greiner, Jeanette, Griksaitis, Michael J, Gupta, Sumit, Hampel, Michal Andrzej, Hastings, Sara Grace, Heenen, Delphine Liliane, Hill, Marcela C, Holiuk, Ihor, Holter, Wolfgang, Hough, Rachael Emma, Hutnik, Lukasz Marek, Irga-Jaworska, Ninela, Istomin, Oleksandr Andriyovych, Ignatova, Anna, Janczar, Szymon Lech, Kacharian, Arman, Kalwak, Krzysztof, Karolczyk, Grażyna Małgorzata, Karpenko, Nataliia Mikolaivna, Katsubo, Halyna Oleksandrivna, Kattamis, Antonis, Kazanowska, Bernarda Jadwiga, Kentsis, Alex, Ketteler, Petra, Kienesberger, Anita, Kiselev, Roman, Kizyma, Zoryana Petrivna, Kliuchkivska, Khrystyna, Klymniuk, Hryhorii Ivanovych, Kolenova, Alexandra, Kolodrubiec, Julia, Kostiuk, Yuliia, Kowalik, Tomasz, Kozlova, Olena Igorivna, Kozubenko, Vladyslav, Kraal, Kathelijne, Kramar, Tetyana Oleksandrivna, Krawczuk-Rybak, Maryna Maryna, Kulemzina, Irina, Kurkowska, Paulina, Kuzyk, Andriy S., Ladenstein, Ruth Lydia, Laguna, Pawel Jozef, Lassaletta, Alvaro, Lehmberg, Kai, Leontieva, Oksana, Liashenko, Serhii, Loizou, Loizos G., Lucchetta, Sonia Anna, Lupo, Matthew William, Lysytsia, Lesya, Lysytsia, Oleksandr, Machnik, Katarzyna Anna, Massimino, Maura, Mainland, Jeff A, Matczak, Katarzyna, Matysiak, Michal Jacek, Mayeur, Pierre, Miller, Beth Anne, Minervina, Anastasia A, Mishkova, Volha, Mizia-Malarz, Agnieszka Joanna, Morales La Madrid, Andres, Moreira, Daniel C, Moreno, Lucas, Moskvin, Vadim P, Mukkada, Sheena Teresa, Muszyńska-Rosłan, Katarzyna Maria, Mykychak, Iryna Volodymyrivna, Niemeyer, Charlotte, Nelson, Akoya Janae', Nogovitsyna, Yuliya, Ociepa, Tomasz, Oltolini, Stefano, Onipko, Nataliia, Pappas, Andrew, Patel, Amit B, Patrahau, Alina Alina, Pauley, Jennifer L., Pavlenko, Yehor Mikhailovich, Pavlovych, Andrij Oleksandrovych, Peregud-Pogorzelski, Jarosław Władyslaw, Perek-Polnik, Marta, Pérez, Vanesa, Pérez-Martínez, Antonio, Pikman, Yana, Pitozzi, Graziano Pitozzi, Portugal, Rui Gentil, Posternak, Victoria Vita, Pleshkan, Viktoriya, Prete, Arcangelo, Pritchard-Jones, Kathy, Raciborska, Anna, Radaelli, Alessandra, Reeves, Tegan Jemma, Reinhardt, Dirk, Reshetnyak, Andrey V, Rider, Andrew Jacob, Rizzari, Carmelo, Rizzi, Damiano Damiano, Rodriguez Hermosillo, Karen Gabriela, Ronenko, Olena Volodymyrivna, Rostkowska, Aneta Olga, Rudko, Liudmyla Yaroslavivna, Sakaan, Firas Mohamed, Sakhar, Nadezhda Aleksandrovna, Salman, Zeena S, Savva, Natallia N., Scaccaglia, Davide, Schaeffer, Elizabeth Hawthorne, Schneider, Carina Ursula, Scobie, Nicole, Semeniuk, Olena Volodymyrivna, Shevchyk, Roksoliana, Shuler, Ana I., Shvets, Stanislav, Sniderman, Liz, Skoczen, Szymon Pawel, Smeal, William John, Sokolowski, Igor, Sonkin, Anna Alexandra, Spolinyak, Andriy, Spota, Andrea, Sramkova, Lucie, Stepanjuk, Alla Ivanivna, Sterba, Jaroslav, Strahm, Brigitte, Styczynski, Jan, Svintsova, Olha, Synyuta, Andriy V, Szczepanski, Tomasz, Szczucinski, Pawel Kukiz, Szmyd, Bartosz Miroslaw, Tasso Cereceda, Maria, Teliuk, Alina, Tomanek, Iwona, Topping, Phoebe, Torrent, Montserrat, Trelińska, Joanna, Troyanovska, Olha Orestivna, Tsurkan, Lyudmila G., Tsymbalyuk-Voloshyn, Iryna, Tyupa, Sergiy Ihorovych, Urasinski, Tomasz Franciszek, Urbanek Dądela, Agnieszka, Vasilieva, Nataliia Jroslavivna, Vasilyeva, Aksana, Verdú-Amorós, Jaime, Vilcu-Bajurean, Natalia, Vinitsky, Leo, Vivtcharenko, Victoria, Vovk, Nelia, Volpe, Giovanni, Vorobel, Oksana Ivanivna, Wachowiak, Jacek Tadeusz, Wasiak, Marcin Slawomir, Wiedower, Lance Allan, Wobst, Natalia, Wuenschel, Lena Isolde, Wysocki, Mariusz Stanislaw, Yurieva, Marina, Zagurska, Anastasiia, Zakharenko, Stanislav S, Zakharenko, Aelita V, Zapotochna, Khrystyna, Zawitkowska, Joanna Emilia, Zecca, Marco, Mueller, Alexandra, Salek, Marta, Oszer, Aleksandra, Evseev, Dmitry, Yakimkova, Taisiya, Wlodarski, Marcin, Vinitsky, Anna, Kizyma, Roman, Pogorelyy, Mikhail, Zuber, Maria, Escalante, Juan, Lipska, Elzbieta, Fendler, Wojciech, Nowicka, Zuzanna, Szyszka, Adam, Rodriguez-Galindo, Carlos, Wise, Paul H., Agulnik, Asya, and Mlynarski, Wojciech

Published
2024
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5. Transition and management of Ukrainian war refugee children on kidney replacement therapy

Author

Maternik, Michal, Andrunevych, Roman, Drozdz, Dorota, Czauderna, Piotr, Grenda, Ryszard, and Tkaczyk, Marcin

Subjects
Russian Invasion of Ukraine, 2022- -- Health aspects, Refugee children -- Care and treatment, Transitional care -- Methods, Health
Abstract

Author(s): Michal Maternik [sup.1] , Roman Andrunevych [sup.2] , Dorota Drozdz [sup.3] , Piotr Czauderna [sup.4] , Ryszard Grenda [sup.5] , Marcin Tkaczyk [sup.6] Author Affiliations: (1) grid.11451.30, 0000 0001 [...]

Published
2023
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6. Pediatric Surgical Oncology

Author

Chardot, Christophe, Youssef, Sabrine Ben, Capito, Carmen, Czauderna, Piotr, Godzinski, Jan, Rokitansky, Alexander, Zachariou, Zacharias, and Zachariou, Zacharias, editor

Published
2022
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7. Second Malignant Neoplasms Following Treatment for Hepatoblastoma: An International Report and Review of the Literature

Author

Trobaugh-Lotrario, Angela, primary, Watanabe, Kenichiro, additional, O’Neill, Allison F., additional, Dembowska-Bagińska, Bozenna, additional, Häberle, Beate, additional, Murphy, Andrew, additional, Hiyama, Eiso, additional, Czauderna, Piotr, additional, Meyers, Rebecka L., additional, Langham, Max, additional, and Feusner, James, additional

Published
2024
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9. Parenchyma Sparing Anatomic Liver Resections (Bi- and Uni-Segmentectomies) for Liver Tumours in Children—A Single-Centre Experience

Author

Murawski, Maciej, primary, Garnier, Hanna, additional, Stefanowicz, Joanna, additional, Sinacka, Katarzyna, additional, Izycka-Swieszewska, Ewa, additional, Sawicka-Zukowska, Malgorzata, additional, Wawrykow, Pawel, additional, Wrobel, Grazyna, additional, Mizia-Malarz, Agnieszka, additional, Marciniak-Stepak, Patrycja, additional, and Czauderna, Piotr, additional

Published
2023
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10. Development of a centralised triage centre for children with cancer and blood disorders in response to the humanitarian crisis in Ukraine

Author

Salek, Marta, primary, Mueller, Alexandra, additional, Alanbousi, Inna, additional, Cepowska, Zuzanna, additional, Dutkiewicz, Malgorzata, additional, Earl, Julian, additional, Evseev, Dmitry, additional, Kizyma, Roman, additional, Kliuchkivska, Khrystyna, additional, Kolodrubiec, Julia, additional, Matczak, Katarzyna, additional, Nogovitsyna, Yuliya, additional, Oszer, Aleksandra, additional, Pogorelyy, Mikhail, additional, Raciborska, Anna, additional, Rasul, Suheir, additional, Sokolowski, Igor, additional, Sopilnyak, Andriy, additional, Vinitsky, Anna, additional, Wlodarski, Marcin W, additional, Wobst, Natalia, additional, Yakimkova, Taisiya, additional, Rodriguez-Galindo, Carlos, additional, Wise, Paul H, additional, Mlynarski, Wojciech, additional, Agulnik, Asya, additional, Alexander, Sarah Weeks, additional, Apel, Anna, additional, Adyrov, Mykhaylo V, additional, Avula, Meghana, additional, Bal, Wioletta Anna, additional, Balwierz, Walentyna Aniela, additional, Basset-Salom, Luisa, additional, Bastardo Blanco, Daniel, additional, Bauer, Karolina Jadwiga, additional, Bayazitov, Ildar T, additional, Berlanga, Pablo, additional, Bhakta, Nickhill Hitesh, additional, Bieniek, Katarzyna Anna, additional, Bien, Ewa Iwona, additional, Blackwood, Christopher Andrew, additional, Blair, Sally Jane, additional, Bodak, Khrystyna Ihorivna, additional, Bordeianu, Irina, additional, Bouffet, Eric, additional, Braganca, Joao Maria, additional, Bucurenci, Mihaela Silvia, additional, Budny, Elżbieta Beata, additional, Budzyn, Andrii, additional, Bumgardner, Christopher Carl, additional, Burditt, Raina Nichole, additional, Burnside Clapp, Victoria, additional, Bykov, Viacheslav Valeriyovych, additional, Cañete, Adela, additional, Carnelli, Monica, additional, Cela, Elena, additional, Chaber, Radoslaw, additional, Cherner-Drieux, Anna, additional, Chubata, Mariya, additional, Clough, Heidi M, additional, Czauderna, Piotr Stefan, additional, Czernicka - Siwecka, Jolanta, additional, Czyzewski, Krzysztof, additional, Dalle, Jean-Hugues, additional, Dashchakovska, Olha, additional, de Koning, Linda A, additional, Dembowska-Baginska, Bozenna Malgorzata, additional, Derwich, Katarzyna, additional, Dirksen, Uta, additional, Dommett, Rachel, additional, Dorosh, Olha Ihorivna, additional, dos Reis Farinha, Nuno Jorge, additional, Drabko, Katarzyna Anna, additional, Dragomir, Monica Desiree, additional, Dworzak, Michael, additional, Dyma, Sergii Vitaliiovych, additional, Eggert, Angelika, additional, English, Martin William, additional, Farren, Becky S, additional, Fedyk, Nataliia Yuriina, additional, Fernández-Teijeiro, Ana, additional, Ferneza, Severyn Romanovych, additional, Foster, Whitney Baer, additional, Fox Irwin, Leeanna Elizabeth, additional, Gałązkowski, Robert Maciej, additional, Ganieva, Galyna, additional, Garanzha, Vasylyna Andriivna, additional, Gelman, Marina S, additional, Godzinski, Jan Krzysztof, additional, Goeres, Anne Françoise, additional, Golban, Rodica, additional, Graetz, Dylan Elizabeth, additional, Greiner, Jeanette, additional, Griksaitis, Michael J, additional, Gupta, Sumit, additional, Hampel, Michal Andrzej, additional, Hastings, Sara Grace, additional, Heenen, Delphine Liliane, additional, Hill, Marcela C, additional, Holiuk, Ihor, additional, Holter, Wolfgang, additional, Hough, Rachael Emma, additional, Hutnik, Lukasz Marek, additional, Irga-Jaworska, Ninela, additional, Istomin, Oleksandr Andriyovych, additional, Ignatova, Anna, additional, Janczar, Szymon Lech, additional, Kacharian, Arman, additional, Kalwak, Krzysztof, additional, Karolczyk, Grażyna Małgorzata, additional, Karpenko, Nataliia Mikolaivna, additional, Katsubo, Halyna Oleksandrivna, additional, Kattamis, Antonis, additional, Kazanowska, Bernarda Jadwiga, additional, Kentsis, Alex, additional, Ketteler, Petra, additional, Kienesberger, Anita, additional, Kiselev, Roman, additional, Kizyma, Zoryana Petrivna, additional, Klymniuk, Hryhorii Ivanovych, additional, Kolenova, Alexandra, additional, Kostiuk, Yuliia, additional, Kowalik, Tomasz, additional, Kozlova, Olena Igorivna, additional, Kozubenko, Vladyslav, additional, Kraal, Kathelijne, additional, Kramar, Tetyana Oleksandrivna, additional, Krawczuk-Rybak, Maryna Maryna, additional, Kulemzina, Irina, additional, Kurkowska, Paulina, additional, Kuzyk, Andriy S., additional, Ladenstein, Ruth Lydia, additional, Laguna, Pawel Jozef, additional, Lassaletta, Alvaro, additional, Lehmberg, Kai, additional, Leontieva, Oksana, additional, Liashenko, Serhii, additional, Loizou, Loizos G., additional, Lucchetta, Sonia Anna, additional, Lupo, Matthew William, additional, Lysytsia, Lesya, additional, Lysytsia, Oleksandr, additional, Machnik, Katarzyna Anna, additional, Massimino, Maura, additional, Mainland, Jeff A, additional, Matysiak, Michal Jacek, additional, Mayeur, Pierre, additional, Miller, Beth Anne, additional, Minervina, Anastasia A, additional, Mishkova, Volha, additional, Mizia-Malarz, Agnieszka Joanna, additional, Morales La Madrid, Andres, additional, Moreira, Daniel C, additional, Moreno, Lucas, additional, Moskvin, Vadim P, additional, Mukkada, Sheena Teresa, additional, Muszyńska-Rosłan, Katarzyna Maria, additional, Mykychak, Iryna Volodymyrivna, additional, Niemeyer, Charlotte, additional, Nelson, Akoya Janae', additional, Ociepa, Tomasz, additional, Oltolini, Stefano, additional, Onipko, Nataliia, additional, Pappas, Andrew, additional, Patel, Amit B, additional, Patrahau, Alina Alina, additional, Pauley, Jennifer L., additional, Pavlenko, Yehor Mikhailovich, additional, Pavlovych, Andrij Oleksandrovych, additional, Peregud-Pogorzelski, Jarosław Władysław, additional, Perek-Polnik, Marta, additional, Pérez, Vanesa, additional, Pérez-Martínez, Antonio, additional, Pikman, Yana, additional, Pitozzi, Graziano Pitozzi, additional, Portugal, Rui Gentil, additional, Posternak, Victoria Vita, additional, Pleshkan, Viktoriya, additional, Prete, Arcangelo, additional, Pritchard-Jones, Kathy, additional, Radaelli, Alessandra, additional, Reeves, Tegan Jemma, additional, Reinhardt, Dirk, additional, Reshetnyak, Andrey V, additional, Rider, Andrew Jacob, additional, Rizzari, Carmelo, additional, Rizzi, Damiano Damiano, additional, Rodriguez Hermosillo, Karen Gabriela, additional, Ronenko, Olena Volodymyrivna, additional, Rostkowska, Aneta Olga, additional, Rudko, Liudmyla Yaroslavivna, additional, Sakaan, Firas Mohamed, additional, Sakhar, Nadezhda Aleksandrovna, additional, Salman, Zeena S, additional, Savva, Natallia N, additional, Scaccaglia, Davide, additional, Schaeffer, Elizabeth Hawthorne, additional, Schneider, Carina Ursula, additional, Scobie, Nicole, additional, Semeniuk, Olena Volodymyrivna, additional, Shevchyk, Roksoliana, additional, Shuler, Ana, additional, Shvets, Stanislav, additional, Sniderman, Liz, additional, Skoczen, Szymon Pawel, additional, Smeal, William John, additional, Sonkin, Anna Alexandra, additional, Spota, Andrea, additional, Sramkova, Lucie, additional, Stepanjuk, Alla Ivanivna, additional, Sterba, Jaroslav, additional, Strahm, Brigitte, additional, Styczynski, Jan, additional, Svintsova, Olha, additional, Synyuta, Andriy V, additional, Szczepanski, Tomasz, additional, Szczucinski, Paweł Kukiz, additional, Szmyd, Bartosz Miroslaw, additional, Tasso Cereceda, Maria, additional, Teliuk, Alina, additional, Tomanek, Iwona, additional, Topping, Phoebe, additional, Torrent, Montserrat, additional, Trelińska, Joanna, additional, Troyanovska, Olha Orestivna, additional, Tsurkan, Lyudmila G., additional, Tsymbalyuk-Voloshyn, Iryna, additional, Tyupa, Sergiy Ihorovych, additional, Urasinski, Tomasz Franciszek, additional, Urbanek Dądela, Agnieszka, additional, Vasilieva, Nataliia Jroslavivna, additional, Vasilyeva, Aksana, additional, Verdú-Amorós, Jaime, additional, Vilcu-Bajurean, Natalia, additional, Vinitsky, Leo, additional, Vivtcharenko, Victoria, additional, Vovk, Nelia, additional, Volpe, Giovanni, additional, Vorobel, Oksana Ivanivna, additional, Wachowiak, Jacek Tadeusz, additional, Wasiak, Marcin Sławomir, additional, Wiedower, Lance Allan, additional, Wuenschel, Lena Isolde, additional, Wysocki, Mariusz Stanislaw, additional, Yurieva, Marina, additional, Zagurska, Anastasiia, additional, Zakharenko, Stanislav S, additional, Zakharenko, Aelita V, additional, Zapotochna, Khrystyna, additional, Zawitkowska, Joanna Emilia, additional, and Zecca, Marco, additional

Published
2023
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11. Computational drug prediction in hepatoblastoma by integrating pan-cancer transcriptomics with pharmacological response

Author

Failli, Mario, primary, Demir, Salih, additional, Del Río-Álvarez, Álvaro, additional, Carrillo-Reixach, Juan, additional, Royo, Laura, additional, Domingo-Sàbat, Montserrat, additional, Childs, Margaret, additional, Maibach, Rudolf, additional, Alaggio, Rita, additional, Czauderna, Piotr, additional, Morland, Bruce, additional, Branchereau, Sophie, additional, Cairo, Stefano, additional, Kappler, Roland, additional, Armengol, Carolina, additional, and di Bernardo, Diego, additional

Published
2023
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12. Parenchyma Sparing Anatomic Liver Resections (Bi- and Uni-Segmentectomies) for Liver Tumours in Children—A Single-Centre Experience.

Author

Murawski, Maciej, Garnier, Hanna, Stefanowicz, Joanna, Sinacka, Katarzyna, Izycka-Swieszewska, Ewa, Sawicka-Zukowska, Malgorzata, Wawrykow, Pawel, Wrobel, Grazyna, Mizia-Malarz, Agnieszka, Marciniak-Stepak, Patrycja, and Czauderna, Piotr

Subjects
LIVER surgery, EPITHELIAL cell tumors, PATIENT aftercare, LIVER tumors, HEPATOBLASTOMA, TIME, SURGICAL complications, SURGICAL margin, DISEASE relapse, CHILDREN
Abstract

Simple Summary: Liver tumours in children are definitely "surgical tumours", and their complete resection is essential for cure. Compared to adults, the extent of resection in children can be much greater; up to 75–85% of the liver parenchyma can be safely resected. However, parenchymal preservation resection (segmentectomy, bisegmentectomy) seems to be a good option in carefully selected patients. There are very few publications regarding minor liver resections in children. From the available literature and data presented here, we propose that (bi)segmentectomy can become a viable surgical option in patients with favourable tumour locations and the absence of portal invasion in imaging. But, when qualifying a child for minor resection, it is important to remember that meeting oncological goals remains the primary objective of liver surgery. Further studies evaluating the impact of parenchymal preservation surgery on surgical and oncological outcome after liver resection in children should be conducted with a larger dataset. Purpose: To present a single-centre experience in bi- and uni-segmentectomies for primary liver tumours in children. Methods: This study included 23 patients that underwent (bi)segmentectomy. There were 15 malignant tumours (hepatoblastoma—13 patients), 7 benign tumours, and 1 calcifying nested stromal epithelial tumour. Results: The median tumour diameter was 52 mm (range 15–170 mm). Bisegmentectomy 2–3 was most frequently performed (seven patients), followed by bisegmentectomy 5–6 (four patients). The median operative time was 225 min (range 95–643 min). Intraoperative complications occurred in two patients—small bowel perforation in one and an injury of the small peripheral bile duct resulting in biloma in the other. The median resection margin in patients with hepatoblastoma was 3 mm (range 1–15 mm). Microscopically negative margin status was achieved in 12 out of 13 patients. There were two recurrences. After a median follow-up time of 38 months (range 12–144 months), all 13 patients with HB were alive with no evidence of disease. Two relapsed patients were alive with no evidence of disease. Conclusions: From the available literature and data presented here, we propose that (bi)segmentectomy can become a viable surgical option in carefully selected paediatric patients and is sufficient to achieve a cure. Further studies evaluating the impact of parenchymal preservation surgery on surgical and oncological outcome should be conducted with a larger dataset. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Development of a centralised triage centre for children with cancer and blood disorders in response to the humanitarian crisis in Ukraine

Author

Alexander, Sarah Weeks, Apel, Anna, Adyrov, Mykhaylo V, Avula, Meghana, Bal, Wioletta Anna, Balwierz, Walentyna Aniela, Basset-Salom, Luisa, Bastardo Blanco, Daniel, Bauer, Karolina Jadwiga, Bayazitov, Ildar T, Berlanga, Pablo, Bhakta, Nickhill Hitesh, Bieniek, Katarzyna Anna, Bien, Ewa Iwona, Blackwood, Christopher Andrew, Blair, Sally Jane, Bodak, Khrystyna Ihorivna, Bordeianu, Irina, Bouffet, Eric, Braganca, Joao Maria, Bucurenci, Mihaela Silvia, Budny, Elżbieta Beata, Budzyn, Andrii, Bumgardner, Christopher Carl, Burditt, Raina Nichole, Burnside Clapp, Victoria, Bykov, Viacheslav Valeriyovych, Cañete, Adela, Carnelli, Monica, Cela, Elena, Chaber, Radoslaw, Cherner-Drieux, Anna, Chubata, Mariya, Clough, Heidi M, Czauderna, Piotr Stefan, Czernicka - Siwecka, Jolanta, Czyzewski, Krzysztof, Dalle, Jean-Hugues, Dashchakovska, Olha, de Koning, Linda A, Dembowska-Baginska, Bozenna Malgorzata, Derwich, Katarzyna, Dirksen, Uta, Dommett, Rachel, Dorosh, Olha Ihorivna, dos Reis Farinha, Nuno Jorge, Drabko, Katarzyna Anna, Dragomir, Monica Desiree, Dworzak, Michael, Dyma, Sergii Vitaliiovych, Eggert, Angelika, English, Martin William, Farren, Becky S, Fedyk, Nataliia Yuriina, Fernández-Teijeiro, Ana, Ferneza, Severyn Romanovych, Foster, Whitney Baer, Fox Irwin, Leeanna Elizabeth, Gałązkowski, Robert Maciej, Ganieva, Galyna, Garanzha, Vasylyna Andriivna, Gelman, Marina S, Godzinski, Jan Krzysztof, Goeres, Anne Françoise, Golban, Rodica, Graetz, Dylan Elizabeth, Greiner, Jeanette, Griksaitis, Michael J, Gupta, Sumit, Hampel, Michal Andrzej, Hastings, Sara Grace, Heenen, Delphine Liliane, Hill, Marcela C, Holiuk, Ihor, Holter, Wolfgang, Hough, Rachael Emma, Hutnik, Lukasz Marek, Irga-Jaworska, Ninela, Istomin, Oleksandr Andriyovych, Ignatova, Anna, Janczar, Szymon Lech, Kacharian, Arman, Kalwak, Krzysztof, Karolczyk, Grażyna Małgorzata, Karpenko, Nataliia Mikolaivna, Katsubo, Halyna Oleksandrivna, Kattamis, Antonis, Kazanowska, Bernarda Jadwiga, Kentsis, Alex, Ketteler, Petra, Kienesberger, Anita, Kiselev, Roman, Kizyma, Zoryana Petrivna, Klymniuk, Hryhorii Ivanovych, Kolenova, Alexandra, Kostiuk, Yuliia, Kowalik, Tomasz, Kozlova, Olena Igorivna, Kozubenko, Vladyslav, Kraal, Kathelijne, Kramar, Tetyana Oleksandrivna, Krawczuk-Rybak, Maryna Maryna, Kulemzina, Irina, Kurkowska, Paulina, Kuzyk, Andriy S., Ladenstein, Ruth Lydia, Laguna, Pawel Jozef, Lassaletta, Alvaro, Lehmberg, Kai, Leontieva, Oksana, Liashenko, Serhii, Loizou, Loizos G., Lucchetta, Sonia Anna, Lupo, Matthew William, Lysytsia, Lesya, Lysytsia, Oleksandr, Machnik, Katarzyna Anna, Massimino, Maura, Mainland, Jeff A, Matysiak, Michal Jacek, Mayeur, Pierre, Miller, Beth Anne, Minervina, Anastasia A, Mishkova, Volha, Mizia-Malarz, Agnieszka Joanna, Morales La Madrid, Andres, Moreira, Daniel C, Moreno, Lucas, Moskvin, Vadim P, Mukkada, Sheena Teresa, Muszyńska-Rosłan, Katarzyna Maria, Mykychak, Iryna Volodymyrivna, Niemeyer, Charlotte, Nelson, Akoya Janae', Ociepa, Tomasz, Oltolini, Stefano, Onipko, Nataliia, Pappas, Andrew, Patel, Amit B, Patrahau, Alina Alina, Pauley, Jennifer L., Pavlenko, Yehor Mikhailovich, Pavlovych, Andrij Oleksandrovych, Peregud-Pogorzelski, Jarosław Władysław, Perek-Polnik, Marta, Pérez, Vanesa, Pérez-Martínez, Antonio, Pikman, Yana, Pitozzi, Graziano Pitozzi, Portugal, Rui Gentil, Posternak, Victoria Vita, Pleshkan, Viktoriya, Prete, Arcangelo, Pritchard-Jones, Kathy, Radaelli, Alessandra, Reeves, Tegan Jemma, Reinhardt, Dirk, Reshetnyak, Andrey V, Rider, Andrew Jacob, Rizzari, Carmelo, Rizzi, Damiano Damiano, Rodriguez Hermosillo, Karen Gabriela, Ronenko, Olena Volodymyrivna, Rostkowska, Aneta Olga, Rudko, Liudmyla Yaroslavivna, Sakaan, Firas Mohamed, Sakhar, Nadezhda Aleksandrovna, Salman, Zeena S, Savva, Natallia N, Scaccaglia, Davide, Schaeffer, Elizabeth Hawthorne, Schneider, Carina Ursula, Scobie, Nicole, Semeniuk, Olena Volodymyrivna, Shevchyk, Roksoliana, Shuler, Ana, Shvets, Stanislav, Sniderman, Liz, Skoczen, Szymon Pawel, Smeal, William John, Sonkin, Anna Alexandra, Spota, Andrea, Sramkova, Lucie, Stepanjuk, Alla Ivanivna, Sterba, Jaroslav, Strahm, Brigitte, Styczynski, Jan, Svintsova, Olha, Synyuta, Andriy V, Szczepanski, Tomasz, Szczucinski, Paweł Kukiz, Szmyd, Bartosz Miroslaw, Tasso Cereceda, Maria, Teliuk, Alina, Tomanek, Iwona, Topping, Phoebe, Torrent, Montserrat, Trelińska, Joanna, Troyanovska, Olha Orestivna, Tsurkan, Lyudmila G., Tsymbalyuk-Voloshyn, Iryna, Tyupa, Sergiy Ihorovych, Urasinski, Tomasz Franciszek, Urbanek Dądela, Agnieszka, Vasilieva, Nataliia Jroslavivna, Vasilyeva, Aksana, Verdú-Amorós, Jaime, Vilcu-Bajurean, Natalia, Vinitsky, Leo, Vivtcharenko, Victoria, Vovk, Nelia, Volpe, Giovanni, Vorobel, Oksana Ivanivna, Wachowiak, Jacek Tadeusz, Wasiak, Marcin Sławomir, Wiedower, Lance Allan, Wuenschel, Lena Isolde, Wysocki, Mariusz Stanislaw, Yurieva, Marina, Zagurska, Anastasiia, Zakharenko, Stanislav S, Zakharenko, Aelita V, Zapotochna, Khrystyna, Zawitkowska, Joanna Emilia, Zecca, Marco, Salek, Marta, Mueller, Alexandra, Alanbousi, Inna, Cepowska, Zuzanna, Dutkiewicz, Malgorzata, Earl, Julian, Evseev, Dmitry, Kizyma, Roman, Kliuchkivska, Khrystyna, Kolodrubiec, Julia, Matczak, Katarzyna, Nogovitsyna, Yuliya, Oszer, Aleksandra, Pogorelyy, Mikhail, Raciborska, Anna, Rasul, Suheir, Sokolowski, Igor, Sopilnyak, Andriy, Vinitsky, Anna, Wlodarski, Marcin W, Wobst, Natalia, Yakimkova, Taisiya, Rodriguez-Galindo, Carlos, Wise, Paul H, Mlynarski, Wojciech, and Agulnik, Asya

Published
2023
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14. Supplementary Data from Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma

Author

Abril-Fornaguera, Jordi, primary, Torrens, Laura, primary, Andreu-Oller, Carmen, primary, Carrillo-Reixach, Juan, primary, Rialdi, Alex, primary, Balaseviciute, Ugne, primary, Pinyol, Roser, primary, Montironi, Carla, primary, Haber, Philipp K., primary, Del Río-Álvarez, Álvaro, primary, Domingo-Sàbat, Montserrat, primary, Royo, Laura, primary, Akers, Nicholas K., primary, Willoughby, Catherine E., primary, Peix, Judit, primary, Torres-Martin, Miguel, primary, Puigvehi, Marc, primary, Cairo, Stefano, primary, Childs, Margaret, primary, Maibach, Rudolf, primary, Alaggio, Rita, primary, Czauderna, Piotr, primary, Morland, Bruce, primary, Losic, Bojan, primary, Mazzaferro, Vincenzo, primary, Guccione, Ernesto, primary, Sia, Daniela, primary, Armengol, Carolina, primary, and Llovet, Josep M., primary

Published
2023
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15. Data from Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma

Author

Abril-Fornaguera, Jordi, primary, Torrens, Laura, primary, Andreu-Oller, Carmen, primary, Carrillo-Reixach, Juan, primary, Rialdi, Alex, primary, Balaseviciute, Ugne, primary, Pinyol, Roser, primary, Montironi, Carla, primary, Haber, Philipp K., primary, Del Río-Álvarez, Álvaro, primary, Domingo-Sàbat, Montserrat, primary, Royo, Laura, primary, Akers, Nicholas K., primary, Willoughby, Catherine E., primary, Peix, Judit, primary, Torres-Martin, Miguel, primary, Puigvehi, Marc, primary, Cairo, Stefano, primary, Childs, Margaret, primary, Maibach, Rudolf, primary, Alaggio, Rita, primary, Czauderna, Piotr, primary, Morland, Bruce, primary, Losic, Bojan, primary, Mazzaferro, Vincenzo, primary, Guccione, Ernesto, primary, Sia, Daniela, primary, Armengol, Carolina, primary, and Llovet, Josep M., primary

Published
2023
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16. Identification ofIGF2as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma

Author

Abril-Fornaguera, Jordi, primary, Torrens, Laura, additional, Andreu-Oller, Carmen, additional, Carrillo-Reixach, Juan, additional, Rialdi, Alex, additional, Balaseviciute, Ugne, additional, Pinyol, Roser, additional, Montironi, Carla, additional, Haber, Philipp K., additional, Del Río-Álvarez, Álvaro, additional, Domingo-Sàbat, Montserrat, additional, Royo, Laura, additional, Akers, Nicholas K., additional, Willoughby, Catherine E., additional, Peix, Judit, additional, Torres-Martin, Miguel, additional, Puigvehi, Marc, additional, Cairo, Stefano, additional, Childs, Margaret, additional, Maibach, Rudolf, additional, Alaggio, Rita, additional, Czauderna, Piotr, additional, Morland, Bruce, additional, Losic, Bojan, additional, Mazzaferro, Vincenzo, additional, Guccione, Ernesto, additional, Sia, Daniela, additional, Armengol, Carolina, additional, and Llovet, Josep M., additional

Published
2023
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17. Consensus classification of pediatric hepatocellular tumors: A report from the Children's Hepatic tumors International Collaboration (CHIC)

Author

Pathologie Pathologen staf, Cancer, Pathologie Groep Van Diest, Cho, Soo Jin, Ranganathan, Sarangarajan, Alaggio, Rita, Maibach, Rudolf, Tanaka, Yukichi, Inoue, Takeshi, Leuschner, Ivo, de Krijger, Ronald, Vokuhl, Christian, Krailo, Mark, Malogolowkin, Marcio, Meyers, Rebecka, Czauderna, Piotr, Hiyama, Eiso, Ansari, Marc, Morland, Bruce, Trobaugh-Lotrario, Angela, O'Neill, Allison F., Rangaswami, Arun, Häberle, Beate, López-Terrada, Dolores, Pathologie Pathologen staf, Cancer, Pathologie Groep Van Diest, Cho, Soo Jin, Ranganathan, Sarangarajan, Alaggio, Rita, Maibach, Rudolf, Tanaka, Yukichi, Inoue, Takeshi, Leuschner, Ivo, de Krijger, Ronald, Vokuhl, Christian, Krailo, Mark, Malogolowkin, Marcio, Meyers, Rebecka, Czauderna, Piotr, Hiyama, Eiso, Ansari, Marc, Morland, Bruce, Trobaugh-Lotrario, Angela, O'Neill, Allison F., Rangaswami, Arun, Häberle, Beate, and López-Terrada, Dolores

Published
2023

18. Outcomes of Patients Treated for Hepatoblastoma with Low Alpha-Fetoprotein and/or Small Cell Undifferentiated Histology: A Report from the Children's Hepatic Tumors International Collaboration (CHIC)

Author

Pathologie Pathologen staf, Trobaugh-Lotrario, Angela D, Maibach, Rudolf, Aronson, Daniel C, Rangaswami, Arun, Häberle, Beate, O'Neill, Allison F, Schmid, Irene, Ansari, Marc, Hishiki, Tomoro, Ranganathan, Sarangarajan, Alaggio, Rita, de Krijger, Ronald R, Tanaka, Yukichi, Cho, Soo-Jin, Vokuhl, Christian, Maxwell, Rebecca, Krailo, Mark, Hiyama, Eiso, Czauderna, Piotr, Finegold, Milton, Feusner, James H, Malogolowkin, Marcio H, Meyers, Rebecka L, Lopez-Terrada, Dolores, Pathologie Pathologen staf, Trobaugh-Lotrario, Angela D, Maibach, Rudolf, Aronson, Daniel C, Rangaswami, Arun, Häberle, Beate, O'Neill, Allison F, Schmid, Irene, Ansari, Marc, Hishiki, Tomoro, Ranganathan, Sarangarajan, Alaggio, Rita, de Krijger, Ronald R, Tanaka, Yukichi, Cho, Soo-Jin, Vokuhl, Christian, Maxwell, Rebecca, Krailo, Mark, Hiyama, Eiso, Czauderna, Piotr, Finegold, Milton, Feusner, James H, Malogolowkin, Marcio H, Meyers, Rebecka L, and Lopez-Terrada, Dolores

Published
2023

19. Rare and Complex Urology: Clinical Overview of ERN eUROGEN

Author

Oomen, Loes, Leijte, Erik, Shilhan, Darren E., Battye, Michelle, Feitz, Wout F.J., Waltregny, David, Van der Aa, Frank, Spinoit, Anne-Françoise, Rösch, Wolfgang H., Schmiedeke, Eberhard, Fisch, Margit, Märzheuser, Stefanie, Gosemann, Jan-Hendrik, Hubertus, Jochen, Rawashdeh, Yazan, Thorup, Jorgen, Heloury, Yves, Leva, Ernesto, Mancini, Mariangela, Bagolan, Pietro, Sacco, Emilio, Verkauskas, Gilvydas, Feitz, Wout, Sloots, Cornelius, Czauderna, Piotr, Mauricio, Maria, Holmdahl, Gundela, Abrahamsson, Kate, Thomas, Kay, Cardozo, Linda, Chapple, Christopher, Sangar, Vijay, Greenwell, Tamsin, Watkin, Nick, Bujons Tur, Anna, Lozano Ortega, Jose, Pérez-Valderrama, Maria Begoña, Gutierrez Baños, Jose, Garcia Aparicio, Luis, Lopez, Manuel, Romero Otero, Javier, Lopez Pereira, Pedro, Herranz Amo, Felipe, Oswald, Josef, Abols, Valts, Frobe, Ana, Judit Molnar, Maria, Goergen, Martine, Dalmas, Miriam, Lovrecic, Luca, and ERN eUROGEN, [missing]

Subjects
eUROGEN, European level, Health Personnel, Urology, education, 030232 urology & nephrology, European Reference Network, Disease, HYPOSPADIAS, Collaboration, Complex conditions, Rare, Rare diseases, 03 medical and health sciences, 0302 clinical medicine, Medicine and Health Sciences, medicine, Humans, EPIDEMIOLOGY, In patient, Patient summary, Retrospective Studies, Data collection, Settore MED/24 - UROLOGIA, business.industry, Retrospective cohort study, medicine.disease, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Data extraction, 030220 oncology & carcinogenesis, Medical emergency, Diagnosis code, business
Abstract

Background: In 2017, the European Commission launched 24 European Reference Networks (ERNs). ERN eUROGEN is the network for urorectogenital diseases and complex conditions, and started with 29 full member healthcare providers (HCPs) in 11 countries. It then covered 19 different disease areas distributed over three work -streams (WSs). Objective: To provide an overview and identify challenges in data collection at European level of the ERN eUROGEN patient population treated by HCPs in the network. Design, setting, and participants: A retrospective cohort study was conducted of the 29 HCPs who were full members between 2013 and 2019. Outcome measurements and statistical analysis: Data were extracted from the original HCP applications and the ERN continuous monitoring system. Patient volumes, new patient numbers, and procedures were compared between different WSs, countries, and HCPs. Discrepancies between monitoring and application data were identified. Results and limitations: Between 2013 and 2019, 122 040 patients required long-term care within the 29 HCPs. The volume of patients treated and procedures undertaken per year increased over time. Large discrepancies were found between patient numbers contained in the application forms and those reported in the continuous monitoring system (0-1357% deviation). Conclusions: Patient numbers and procedures increased across ERN eUROGEN HCPs. Reliable data extraction appeared challenging, illustrated by the patient volume dis-crepancies between application forms and the continuous monitoring data. Improved disease definitions, re-evaluation of affiliated HCPs, and valid data extraction are needed for future improvements. Patient summary: We analysed the patient population with rare urorectogenital dis-eases or complex conditions within the ERN eUROGEN network between 2013 and 2019. Clinical activity was found to increase, but differences in patient numbers were evident between healthcare providers. In order to acquire valid patient numbers, both improved definitions of diagnostic codes and greater insight into the data-gathering process are required. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).

Published
2022

20. Impact of COVID-19 pandemic on paediatric surgical training across Europe

Author

Zambaiti, Elisa, primary, Cascio, Salvatore, additional, Pelizzo, Gloria, additional, Siles Hinojosa, Alexander, additional, de Augustin Asensio, Juan Carlos, additional, Fortmann, Caroline, additional, Lacher, Martin, additional, Malowiecka, Maria, additional, Czauderna, Piotr, additional, Arneitz, Christoph, additional, Till, Holger, additional, Glenisson, Mathilde, additional, Bonnard, Arnaud, additional, Hoel, Anders Telle, additional, Bjørnland, Kristin, additional, Hukkinen, Maria, additional, Demetrios, Godosis, additional, Zavras, Nikolaos, additional, Reusens, Helena, additional, Steyaert, Henri, additional, Pevere, Andrea, additional, Aubert, Ophelia, additional, and Pio, Luca, additional

Published
2022
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22. Abstract PO009: Identification of IGF2 as genomic driver and actionable therapeutic target in hepatoblastoma

Author

Abril-Fornaguera, Jordi, primary, Torrens, Laura, additional, Carrillo-Reixach, Juan, additional, Rialdi, Alex, additional, Balaseviciute, Ugne, additional, Huguet-Pradell, Júlia, additional, Montironi, Carla, additional, Haber, Philipp, additional, Del Río-Álvarez, Álvaro, additional, Domingo-Sàbat, Montserrat, additional, Royo, Laura, additional, Akers, Nicholas, additional, Willoughby, Catherine E, additional, Peix, Judit, additional, Torres-Martin, Miguel, additional, Puigvehi, Marc, additional, Pinyol, Roser, additional, Cairo, Stefano, additional, Childs, Margaret, additional, Maibach, Rudolf, additional, Alaggio, Rita, additional, Czauderna, Piotr, additional, Morland, Bruce, additional, Losic, Bojan, additional, Mazzaferro, Vincenzo, additional, Guccione, Ernesto, additional, Sia, Daniela, additional, Armengol, Carolina, additional, and Llovet, Josep M, additional

Published
2022
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23. Abstract PO010: Molecular characterization of pediatric hepatocellular carcinoma: genomic, methylomic and transcriptomic analysis

Author

Carrillo-Reixach, Juan, primary, del Río-Álvarez, Álvaro, additional, Royo, Laura, additional, Domingo-Sàbat, Montserrat, additional, Alaggio, Rita, additional, de Krijger, Ronald, additional, Vokuhl, Christian, additional, Garrido, Marta, additional, Guerra, Laura, additional, Sábado, Constantino, additional, Hernández, Francisco, additional, López-Santamaría, Manuel, additional, Bajčiová, Viera, additional, Maibach, Rudolf, additional, Childs, Margaret, additional, Czauderna, Piotr, additional, Wheatley, Keith, additional, Kappler, Roland, additional, Cairo, Stefano, additional, Morland, Bruce, additional, Sala, Margarita, additional, Sarrias, Maria Rosa, additional, and Armengol, Carolina, additional

Published
2022
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24. Abstract PO011: Proteomic profiling of childhood liver cancer: identification of novel diagnostic and prognostic biomarkers

Author

Del Río-Álvarez, Álvaro, primary, Carrillo-Reixach, Juan, additional, Royo, Laura, additional, Domingo-Sàbat, Montse, additional, Azkargorta, Mikel, additional, Kapler, Roland, additional, Cairo, Stefano, additional, Vokuhl, Christian, additional, de Krijger, Ronald, additional, Alaggio, Rita, additional, Garrido, Marta, additional, Guillen, Gabriela, additional, Sábado, Constantino, additional, Guerra, Laura, additional, Hernandez, Francisco, additional, Mateos, Maria Elena, additional, López-Satamaría, Manuel, additional, Torres, Barbara, additional, Abad, Maria Pilar, additional, Viera, Bajčiová, additional, Czauderna, Piotr, additional, Buendia, Marie Annick, additional, Elortza, Felix, additional, Wheatley, Keith, additional, Morland, Bruce, additional, and Armengol, Carolina, additional

Published
2022
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25. Global effort to evacuate Ukrainian children with cancer and blood disorders who have been affected by war

Author

Agulnik, Asya, primary, Kizyma, Roman, additional, Salek, Marta, additional, Wlodarski, Marcin W, additional, Pogorelyy, Mikhail, additional, Oszer, Aleksandra, additional, Yakimkova, Taisiya, additional, Nogovitsyna, Yuliya, additional, Dutkiewicz, Malgorzata, additional, Dalle, Jean-Hugues, additional, Dirksen, Uta, additional, Eggert, Angelika, additional, Fernández-Teijeiro, Ana, additional, Greiner, Jeanette, additional, Kraal, Kathelijne, additional, Mueller, Alexandra, additional, Sramkova, Lucie, additional, Zecca, Marco, additional, Wise, Paul H, additional, Mlynarski, Wojciech, additional, Avula, Meghana, additional, Adyrov, Mykhaylo V, additional, Berlanga, Pablo, additional, Blackwood, Christopher Andrew, additional, Bouffet, Eric, additional, Czauderna, Piotr Stefan, additional, de Koning, Linda A, additional, dos Reis Farinha, Nuno Jorge, additional, Foster, Whitney Baer, additional, Graetz, Dylan Elizabeth, additional, Gupta, Sumit, additional, Holter, Wolfgang, additional, Hough, Rachael Emma, additional, Kliuchkivska, Khrystyna, additional, Kolenova, Alexandra, additional, Kołodrubiec, Julia, additional, Moreira, Daniel C, additional, Mukkada, Sheena Teresa, additional, Mykychak, Iryna, additional, Raciborska, Anna, additional, Salman, Zeena S, additional, Sopilnyak, Andriy, additional, Tyupa, Sergiy, additional, Vinitsky, Anna, additional, Wobst, Natalia Margarete, additional, Miller, Beth Anne, additional, Rasul, Suheir Subhi, additional, Rodriguez-Galindo, Carlos, additional, Alanbousi, Inna, additional, Alexander, Sarah Weeks, additional, Apel, Anna, additional, Bal, Wioletta Anna, additional, Balwierz, Walentyna Aniela, additional, Basset-Salom, Luisa, additional, Bastardo Blanco, Daniel, additional, Bauer, Karolina Jadwiga, additional, Bayazitov, Ildar T, additional, Bhakta, Nickhill Hitesh, additional, Bien, Ewa Iwona, additional, Bieniek, Katarzyna Anna, additional, Blair, Sally Jane, additional, Bodak, Khrystyna Ihorivna, additional, Bordeianu, Irina Michael, additional, Braganca, Joao Maria, additional, Bucurenci, Mihaela Silvia, additional, Budny, Elżbieta Beata, additional, Budzyn, Andrii, additional, Bumgardner, Christopher Carl, additional, Burditt, Raina Nichole, additional, Burnside Clapp, Victoria Grace, additional, Bykov, Viacheslav, additional, Cañete, Adela, additional, Carnelli, Monica, additional, Cela, Elena, additional, Cepowska, Zuzanna Paulina, additional, Chaber, Radoslaw, additional, Cherner-Drieux, Anna, additional, Chubata, Mariya, additional, Clough, Heidi M, additional, Czernicka - Siwecka, Jolanta, additional, Czyzewski, Krzysztof, additional, Dashchakovska, Olha, additional, Dembowska-Baginska, Bozenna Malgorzata, additional, Derwich, Katarzyna, additional, Dommett, Rachel, additional, Dorosh, Olha, additional, Drabko, Katarzyna Anna, additional, Dragomir, Monica Desiree, additional, Dworzak, Michael, additional, Dyma, Sergii, additional, Earl, Julian Darocus, additional, English, Martin William, additional, Evseev, Dmitry A, additional, Farren, Becky S, additional, Fedyk, Nataliia, additional, Ferneza, Severyn, additional, Fox Irwin, Leeanna Elizabeth, additional, Gałązkowski, Robert Maciej, additional, Ganieva, Galyna, additional, Garanzha, Vasylyna, additional, Gelman, Marina S, additional, Godzinski, Jan Krzysztof, additional, Goeres, Anne Francoise, additional, Golban, Rodica, additional, Griksaitis, Michael J, additional, Hampel, Michal Andrzej, additional, Hastings, Sara Grace, additional, Heenen, Delphine Liliane, additional, Hill, Marcela C, additional, Holiuk, Igor, additional, Hutnik, Lukasz Marek, additional, Irga-Jaworska, Ninela, additional, Istomin, Oleksandr, additional, Janczar, Szymon Lech, additional, Kacharian, Arman, additional, Kalwak, Krzysztof, additional, Karolczyk, Grażyna Malgorzata, additional, Karpenko, Nataliia Mikolaivna, additional, Katsubo, Halyna, additional, Kaznowska, Bernarda Jadwiga, additional, Kentsis, Alex, additional, Ketteler, Petra, additional, Kienesberger, Anita, additional, Kiselev, Roman, additional, Kizyma, Zoryana, additional, Klymniuk, Hryhorii, additional, Kostiuk, Yuliia, additional, Kowalik, Tomasz, additional, Kozlova, Olena, additional, Kozubenko, Vladyslav, additional, Kramar, Tetyana, additional, Krawczuk-Rybak, Maryna, additional, Kulemzina, Irina, additional, Kurkowska, Paulina, additional, Kuzyk, Andriy S, additional, Ladenstein, Ruth Lydia, additional, Laguna, Pawel Jozef, additional, Lassaletta, Alvaro, additional, Lehmberg, Kai, additional, Leontieva, Oksana, additional, Liashenko, Serhii, additional, Loizou, Loizos G, additional, Lucchetta, Sonia Anna, additional, Lupo, Matthew William, additional, Lysytsia, Lesya, additional, Lysytsia, Oleksandr, additional, Machnik, Katarzyna Anna, additional, Mainland, Jeff A, additional, Matczak, Katarzyna Ewa, additional, Matysiak, Michal Jacek, additional, Mayeur, Pierre, additional, Minervina, Anastasia A, additional, Mishkova, Volha, additional, Mizia-Malarz, Agnieszka Joanna, additional, Morales La Madrid, Andres, additional, Moreno, Lucas, additional, Moskvin, Vadim P, additional, Muszyńska-Rosłan, Katarzyna Maria, additional, Nelson, Akoya Janae, additional, Ociepa, Tomasz, additional, Oltolini, Stefano, additional, Onipko, Nataliia, additional, Pappas, Andrew, additional, Patel, Amit B, additional, Patrahau, Alina, additional, Pauley, Jennifer L, additional, Pavlenko, Yehor, additional, Pavlovych, Andrij, additional, Peregud-Pogorzelski, Jarosław, additional, Perek-Polnik, Marta, additional, Perez, Vanesa, additional, Perez-Martinez, Antonio, additional, Pikman, Yana, additional, Pitozzi, Graziano, additional, Portugal, Rui Gentil, additional, Posternak, Victoria Vita, additional, Prete, Arcangelo, additional, Pritchard-Jones, Kathy, additional, Radaelli, Alessandra, additional, Reeves, Tegan, additional, Reinhardt, Dirk, additional, Reshetnyak, Andrey V, additional, Rider, Andrew Jacob, additional, Rizzari, Carmelo, additional, Rizzi, Damiano, additional, Rodriguez Hermosillo, Karen Gabriela, additional, Ronenko, Olena, additional, Rostowska, Aneta Olga, additional, Rudko, Liudmyla, additional, Sakaan, Firas Mohamed, additional, Sakhar, Nadezhda, additional, Savva, Natallia N, additional, Scaccaglia, Davide, additional, Schaeffer, Elizabeth Hawthorne, additional, Schneider, Carina Ursula, additional, Scobie, Nicole, additional, Semeniuk, Olena, additional, Shevchyk, Roksoliana, additional, Shuler, Ana I, additional, Shvets, Stanislav, additional, Skoczen, Szymon Pawel, additional, Smeal, William John, additional, Sokolowski, Igor, additional, Sonkin, Anna A, additional, Stepanjuk, Alla Ivanivna, additional, Spota, Andrea, additional, Sterba, Jaroslav, additional, Styczynski, Jan, additional, Svintsova, Olha, additional, Synyuta, Andriy V, additional, Szczepanski, Tomasz, additional, Szczucinski, Paweł Kukiz, additional, Szmyd, Bartosz Miroslaw, additional, Tasso Cereceda, Maria, additional, Teliuk, Alina, additional, Tomanek, Iwona, additional, Topping, Phoebe, additional, Torrent, Montserrat, additional, Trelińska, Joanna, additional, Troyanovska, Olha, additional, Trubnikova, Elena, additional, Tsurkan, Lyudmila G, additional, Tsymbalyuk-Voloshyn, Iryna, additional, Urasinski, Tomasz Franciszek, additional, Urbanek-Dadela, Agnieszka, additional, Vasilieva, Nataliia, additional, Vasilyeva, Aksana, additional, Verdú-Amorós, Jaime, additional, Vilcu-Bajurean, Natalia, additional, Vinitsky, Leo, additional, Volpe, Giovanni, additional, Vorobel, Oksana, additional, Wachowiak, Jacek Tadeusz, additional, Wasiak, Marcin Slawomir, additional, Wiedower, Lance Allan, additional, Wuenschel, Lena Isolde, additional, Wysocki, Mariusz Stanislaw, additional, Yurieva, Marina, additional, Zagurska, Anastasiia, additional, Zakharenko, Stanislav S, additional, Zakharenko, Aelita V, additional, Zapotochna, Khrystyna, additional, and Zawitkowska, Joanna Emilia, additional

Published
2022
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27. Abstract 4005: Identification of IGF2 as genomic driver and actionable therapeutic target in hepatoblastoma

Author

Abril-Fornaguera, Jordi, primary, Torrens, Laura, additional, Carrillo-Reixach, Juan, additional, Rialdi, Alexander, additional, Balaseviciute, Ugne, additional, Montironi, Carla, additional, Haber, Philipp, additional, Río-Álvarez, Álvaro Del, additional, Domingo-Sàbat, Montserrat, additional, Royo, Laura, additional, Akers, Nicholas, additional, Willoughby, Catherine E., additional, Peix, Judit, additional, Torres-Martin, Miguel, additional, Puigvehi, Marc, additional, Pinyol, Roser, additional, Cairo, Stefano, additional, Childs, Margaret, additional, Maibach, Rudolf, additional, Alaggio, Rita, additional, Czauderna, Piotr, additional, Morland, Bruce, additional, Losic, Bojan, additional, Mazzaferro, Vincenzo, additional, Guccione, Ernesto, additional, Sia, Daniela, additional, Armengol, Carolina, additional, and Llovet, Josep M., additional

Published
2022
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28. Laparoscopic nephron-sparing surgery and laparoscopic nephrectomy for Wilms' tumor.

Author

Murawski, Maciej, Stefanowicz, Joanna, Łosin, Marcin, Gołębiewski, Andrzej, and Czauderna, Piotr

Subjects
NEPHROBLASTOMA, LAPAROSCOPIC surgery, NEPHRECTOMY, NEOADJUVANT chemotherapy, LUPUS nephritis, KIDNEY tumors, PATHOLOGY
Abstract

Introduction: The place of laparoscopy in the resection of Wilms' tumors has remained debatable, but evidence that neoadjuvant chemotherapy causes tumor shrinkage has made laparoscopic nephrectomy (LN) a feasible option. Laparoscopic nephron-sparing surgery (NSS) is technically very demanding and seems to be feasible and effective only when performed by a very experienced surgeon. Aim: We report 7 cases of laparoscopic nephrectomy and 1 case of laparoscopic heminephrectomy for Wilms' tumor. Material and methods: Forty-two consecutive children with primary renal tumor underwent nephrectomy between 2013 and 2020; 11 had an LN. Among them there were 8 children with Wilms' tumor, with age between 13 months and 7 years. All patients received neoadjuvant chemotherapy according to the current SIOP protocol. The mean tumor volume before and after chemotherapy was 174.4 ml (range: 14.7-501) and 32.8 ml (range: 4.3-68) respectively. Results: Seven laparoscopic nephrectomies and one heminephrectomy were performed. No patient had an intraoperative tumor rupture. All children had an attempt of lymph node sampling (their number per pathology assessment was in the range 0-5). There were no intraoperative events. One complication after heminephrectomy occurred, which was urine leak. Five patients had stage I tumor and 3 had stage II. Seven patients had an intermediate-risk and one had a high-risk tumor. There were no local or distant relapses. All patients remained disease-free at a median follow-up of 71 months (range: 16-94). Conclusions: This report demonstrates the feasibility of LN in children with Wilms' tumors. The patients should be carefully selected and specific training in laparoscopy is necessary, particularly with regard to laparoscopic heminephrectomy. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Case Report: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Application in Intraperitoneally Disseminated Inflammatory Myofibroblastic Tumor and in the Youngest Patient in the World: New Indication and Modification of Technique

Author

Garnier, Hanna, primary, Murawski, Maciej, additional, Jastrzebski, Tomasz, additional, Pawinska-Wasikowska, Katarzyna, additional, Balwierz, Walentyna, additional, Sinacka, Katarzyna, additional, Gorecki, Wojciech, additional, Izycka-Swieszewska, Ewa, additional, and Czauderna, Piotr, additional

Published
2021
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31. Global effort to evacuate Ukrainian children with cancer and blood disorders who have been affected by war

Author

Avula, Meghana, Adyrov, Mykhaylo V, Berlanga, Pablo, Blackwood, Christopher Andrew, Bouffet, Eric, Czauderna, Piotr Stefan, de Koning, Linda A, dos Reis Farinha, Nuno Jorge, Foster, Whitney Baer, Graetz, Dylan Elizabeth, Gupta, Sumit, Holter, Wolfgang, Hough, Rachael Emma, Kliuchkivska, Khrystyna, Kolenova, Alexandra, Kołodrubiec, Julia, Moreira, Daniel C, Mukkada, Sheena Teresa, Mykychak, Iryna, Raciborska, Anna, Salman, Zeena S, Sopilnyak, Andriy, Tyupa, Sergiy, Vinitsky, Anna, Wobst, Natalia Margarete, Miller, Beth Anne, Rasul, Suheir Subhi, Rodriguez-Galindo, Carlos, Alanbousi, Inna, Alexander, Sarah Weeks, Apel, Anna, Bal, Wioletta Anna, Balwierz, Walentyna Aniela, Basset-Salom, Luisa, Bastardo Blanco, Daniel, Bauer, Karolina Jadwiga, Bayazitov, Ildar T, Bhakta, Nickhill Hitesh, Bien, Ewa Iwona, Bieniek, Katarzyna Anna, Blair, Sally Jane, Bodak, Khrystyna Ihorivna, Bordeianu, Irina Michael, Braganca, Joao Maria, Bucurenci, Mihaela Silvia, Budny, Elżbieta Beata, Budzyn, Andrii, Bumgardner, Christopher Carl, Burditt, Raina Nichole, Burnside Clapp, Victoria Grace, Bykov, Viacheslav, Cañete, Adela, Carnelli, Monica, Cela, Elena, Cepowska, Zuzanna Paulina, Chaber, Radoslaw, Cherner-Drieux, Anna, Chubata, Mariya, Clough, Heidi M, Czernicka - Siwecka, Jolanta, Czyzewski, Krzysztof, Dashchakovska, Olha, Dembowska-Baginska, Bozenna Malgorzata, Derwich, Katarzyna, Dommett, Rachel, Dorosh, Olha, Drabko, Katarzyna Anna, Dragomir, Monica Desiree, Dworzak, Michael, Dyma, Sergii, Earl, Julian Darocus, English, Martin William, Evseev, Dmitry A, Farren, Becky S, Fedyk, Nataliia, Ferneza, Severyn, Fox Irwin, Leeanna Elizabeth, Gałązkowski, Robert Maciej, Ganieva, Galyna, Garanzha, Vasylyna, Gelman, Marina S, Godzinski, Jan Krzysztof, Goeres, Anne Francoise, Golban, Rodica, Griksaitis, Michael J, Hampel, Michal Andrzej, Hastings, Sara Grace, Heenen, Delphine Liliane, Hill, Marcela C, Holiuk, Igor, Hutnik, Lukasz Marek, Irga-Jaworska, Ninela, Istomin, Oleksandr, Janczar, Szymon Lech, Kacharian, Arman, Kalwak, Krzysztof, Karolczyk, Grażyna Malgorzata, Karpenko, Nataliia Mikolaivna, Katsubo, Halyna, Kaznowska, Bernarda Jadwiga, Kentsis, Alex, Ketteler, Petra, Kienesberger, Anita, Kiselev, Roman, Kizyma, Zoryana, Klymniuk, Hryhorii, Kostiuk, Yuliia, Kowalik, Tomasz, Kozlova, Olena, Kozubenko, Vladyslav, Kramar, Tetyana, Krawczuk-Rybak, Maryna, Kulemzina, Irina, Kurkowska, Paulina, Kuzyk, Andriy S, Ladenstein, Ruth Lydia, Laguna, Pawel Jozef, Lassaletta, Alvaro, Lehmberg, Kai, Leontieva, Oksana, Liashenko, Serhii, Loizou, Loizos G, Lucchetta, Sonia Anna, Lupo, Matthew William, Lysytsia, Lesya, Lysytsia, Oleksandr, Machnik, Katarzyna Anna, Mainland, Jeff A, Matczak, Katarzyna Ewa, Matysiak, Michal Jacek, Mayeur, Pierre, Minervina, Anastasia A, Mishkova, Volha, Mizia-Malarz, Agnieszka Joanna, Morales La Madrid, Andres, Moreno, Lucas, Moskvin, Vadim P, Muszyńska-Rosłan, Katarzyna Maria, Nelson, Akoya Janae, Ociepa, Tomasz, Oltolini, Stefano, Onipko, Nataliia, Pappas, Andrew, Patel, Amit B, Patrahau, Alina, Pauley, Jennifer L, Pavlenko, Yehor, Pavlovych, Andrij, Peregud-Pogorzelski, Jarosław, Perek-Polnik, Marta, Perez, Vanesa, Perez-Martinez, Antonio, Pikman, Yana, Pitozzi, Graziano, Portugal, Rui Gentil, Posternak, Victoria Vita, Prete, Arcangelo, Pritchard-Jones, Kathy, Radaelli, Alessandra, Reeves, Tegan, Reinhardt, Dirk, Reshetnyak, Andrey V, Rider, Andrew Jacob, Rizzari, Carmelo, Rizzi, Damiano, Rodriguez Hermosillo, Karen Gabriela, Ronenko, Olena, Rostowska, Aneta Olga, Rudko, Liudmyla, Sakaan, Firas Mohamed, Sakhar, Nadezhda, Savva, Natallia N, Scaccaglia, Davide, Schaeffer, Elizabeth Hawthorne, Schneider, Carina Ursula, Scobie, Nicole, Semeniuk, Olena, Shevchyk, Roksoliana, Shuler, Ana I, Shvets, Stanislav, Skoczen, Szymon Pawel, Smeal, William John, Sokolowski, Igor, Sonkin, Anna A, Stepanjuk, Alla Ivanivna, Spota, Andrea, Sterba, Jaroslav, Styczynski, Jan, Svintsova, Olha, Synyuta, Andriy V, Szczepanski, Tomasz, Szczucinski, Paweł Kukiz, Szmyd, Bartosz Miroslaw, Tasso Cereceda, Maria, Teliuk, Alina, Tomanek, Iwona, Topping, Phoebe, Torrent, Montserrat, Trelińska, Joanna, Troyanovska, Olha, Trubnikova, Elena, Tsurkan, Lyudmila G, Tsymbalyuk-Voloshyn, Iryna, Urasinski, Tomasz Franciszek, Urbanek-Dadela, Agnieszka, Vasilieva, Nataliia, Vasilyeva, Aksana, Verdú-Amorós, Jaime, Vilcu-Bajurean, Natalia, Vinitsky, Leo, Volpe, Giovanni, Vorobel, Oksana, Wachowiak, Jacek Tadeusz, Wasiak, Marcin Slawomir, Wiedower, Lance Allan, Wuenschel, Lena Isolde, Wysocki, Mariusz Stanislaw, Yurieva, Marina, Zagurska, Anastasiia, Zakharenko, Stanislav S, Zakharenko, Aelita V, Zapotochna, Khrystyna, Zawitkowska, Joanna Emilia, Agulnik, Asya, Kizyma, Roman, Salek, Marta, Wlodarski, Marcin W, Pogorelyy, Mikhail, Oszer, Aleksandra, Yakimkova, Taisiya, Nogovitsyna, Yuliya, Dutkiewicz, Malgorzata, Dalle, Jean-Hugues, Dirksen, Uta, Eggert, Angelika, Fernández-Teijeiro, Ana, Greiner, Jeanette, Kraal, Kathelijne, Mueller, Alexandra, Sramkova, Lucie, Zecca, Marco, Wise, Paul H, and Mlynarski, Wojciech

Published
2022
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32. UEMS Section and Board of Paediatric Surgery-A Historical Perspective.

Author

Parigi, Gian Battista, Rolle, Udo, Cascio, Salvatore, Williams, Jacob, and Czauderna, Piotr

Subjects
PEDIATRIC surgery, PEDIATRIC therapy, MEDICAL specialties & specialists, SURGICAL education, SURGERY, WORK experience (Employment)
Abstract

The European Union of Medical Specialists (UEMS) Section and Board of Pediatric surgery was founded more than 40 years ago. Since then major activities have been related to the improvement of quality of care of pediatric surgery in Europe. Remarkable success was achieved in the development of pediatric surgery as an independent specialty all over Europe. Other major successful activities of the UEMS Section and Board of Pediatric Surgery consisted of the development of a high-quality European examination and delineating a minimal common standard in pediatric surgery training in the form of European training requirements. Recommendations drawn from examination experience support that candidates who achieve weaker passes in part 1 may wish to consider more practice before attempting part 2 due to the weak correlation between the two scores. It may be helpful for candidates to consider having some experience working in an English-speaking clinical setting, if not truly fluent in English, to improve their chances of being successful in the part 2 examination. Other achievements of the Section were accreditation of the training centers in Europe and European Census in pediatric surgery project. All the aforementioned activities led to standardization and harmonization of pediatric surgery, as well as contributed to increasing quality of pediatric surgical service throughout Europe. [ABSTRACT FROM AUTHOR]

Published
2021
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34. Minimally invasive surgery in paediatric surgical oncology.

Author

Ribeiro, Rodrigo Chaves, Blanc, Thomas, Le, Hau D., Pio, Luca, Pachl, Max, Avanzini, Stefano, Matthyssens, Lucas E., Bouty, Aurore, and Czauderna, Piotr

Subjects
*FERTILITY preservation, *NEPHRECTOMY, *MINIMALLY invasive procedures, *PEDIATRIC surgery, *PANCREATIC tumors, *PEDIATRIC oncology, *ONCOLOGIC surgery, *NEUROBLASTOMA
Published
2022
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35. Liver tumours: paediatric hepatocellular carcinoma.

Author

Hiyama, Eiso, Meyers, Rebecka, Baertschiger, Reto, Tiao, Greg, Aronson, Daniel, Czauderna, Piotr, Wilde, Jim, Branchereau, Sophie, Gonzalez, Gloria, Jindal, Bibekanand, and Peters, Nitin

Subjects
*HEPATOCELLULAR carcinoma, *PEDIATRICS, *TUMORS
Published
2022
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36. Liver tumours: hepatoblastoma.

Author

Meyers, Rebecka, Baertschiger, Reto, Tiao, Greg, Hiyama, Eiso, Aronson, Daniel, Czauderna, Piotr, Wilde, Jim, Branchereau, Sophie, Gonzalez, Gloria, Jindal, Bibekanand, and Peters, Nitin James

Subjects
*OTOTOXICITY, *NEUROECTODERMAL tumors, *TUMORS, *HEPATOBLASTOMA, *LIVER, *LIVER surgery, *VERY low birth weight
Published
2022
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37. Upfront or delayed surgery in resectable hepatoblastoma: analysis from the children's hepatic tumors international collaboration database.

Author

Hiyama E, Hishiki T, Yoshimura K, Krailo M, Maibach R, Haeberle B, Rangaswami A, Lopez-Terrada D, Malogolowkin MH, Ansari M, Alaggio R, O'Neill AF, Trobaugh-Lotrario AD, Watanabe K, Schmid I, Ranganathan S, Tanaka Y, Inoue T, Piao J, Lin J, Czauderna P, Meyers RL, and Aronson DC

Abstract

Background: In the treatment of resectable hepatoblastoma (HB), it has not been established whether upfront surgery (UF) at diagnosis or neoadjuvant chemotherapy and delayed surgery (DL) is preferred. We compared patients with localized HB who underwent either UF, or DL after neoadjuvant chemotherapy in the Children's Hepatic tumors International Collaboration (CHIC) database of 1605 cases enrolled in eight multicenter hepatoblastoma trials between 1988 and 2010., Methods: Among the 512 resectable HB patients who had PRETEXT (PRETreament EXTent of disease) I or II unruptured tumors at diagnosis without extrahepatic invasion, distant metastases, or massive vascular invasion, 172 underwent UF and 340 underwent DL. The primary outcomes were event-free and overall survivals after start of treatment in these two groups. Survival analysis was performed using the Kaplan-Maier analysis with long-rank tests and multivariable Cox regression models., Findings: Complete resection rates were comparable (93.6% in UF and 89.7% in DL). The total cycles of chemotherapy of DL (median:6) were significantly more than those of UF (median:4) ( P  < 0.01). The 5-year event-free survival (EFS) was 90.6% and 86.6% ( P  = 0.89) in the UF and DL cohorts, respectively. The surgical complications, recurrence rates, and late complications were not significantly different between the cohorts but the EFS rates of DL patients with a low alpha-fetoprotein (AFP) level (100-999 ng/mL) or older age at diagnosis (≥3 years old) were significantly worse than others., Interpretation: The outcomes, surgical resectability, and complications were not significantly different between the UF and DL groups. Eligible patients with a low AFP level (<1000 ng/mL) or older age (≥3 years old) showed better outcomes in the UF group and might be considered for initial resection., Funding: European Network for Cancer Research in Children and Adolescents, funded through the Framework Program 7 of the European Commission; Children's Oncology Group Cure Search grant contributed by the Hepatoblastoma Foundation; Practical Research for Innovative Cancer Control and Project Promoting Clinical Trials for Development of New Drugs and Medical Devices, Japan Agency for Medical Research and Development; Japan Society for the Promotion of Science; and Swiss Cancer Research grant., Competing Interests: We declare no competing interests., (© 2024 The Authors.)

Published
2024
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38. Laparoscopic nephron-sparing surgery and laparoscopic nephrectomy for Wilms' tumor.

Author

Murawski M, Stefanowicz J, Łosin M, Gołębiewski A, and Czauderna P

Abstract

Introduction: The place of laparoscopy in the resection of Wilms' tumors has remained debatable, but evidence that neoadjuvant chemotherapy causes tumor shrinkage has made laparoscopic nephrectomy (LN) a feasible option. Laparoscopic nephron-sparing surgery (NSS) is technically very demanding and seems to be feasible and effective only when performed by a very experienced surgeon., Aim: We report 7 cases of laparoscopic nephrectomy and 1 case of laparoscopic heminephrectomy for Wilms' tumor., Material and Methods: Forty-two consecutive children with primary renal tumor underwent nephrectomy between 2013 and 2020; 11 had an LN. Among them there were 8 children with Wilms' tumor, with age between 13 months and 7 years. All patients received neoadjuvant chemotherapy according to the current SIOP protocol. The mean tumor volume before and after chemotherapy was 174.4 ml (range: 14.7-501) and 32.8 ml (range: 4.3-68) respectively., Results: Seven laparoscopic nephrectomies and one heminephrectomy were performed. No patient had an intraoperative tumor rupture. All children had an attempt of lymph node sampling (their number per pathology assessment was in the range 0-5). There were no intraoperative events. One complication after heminephrectomy occurred, which was urine leak. Five patients had stage I tumor and 3 had stage II. Seven patients had an intermediate-risk and one had a high-risk tumor. There were no local or distant relapses. All patients remained disease-free at a median follow-up of 71 months (range: 16-94)., Conclusions: This report demonstrates the feasibility of LN in children with Wilms' tumors. The patients should be carefully selected and specific training in laparoscopy is necessary, particularly with regard to laparoscopic heminephrectomy., Competing Interests: The authors declare no conflict of interest, (Copyright © 2023 Sekcja Wideochirurgii TChP.)

Published
2023
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39. Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma.

Author

Abril-Fornaguera J, Torrens L, Andreu-Oller C, Carrillo-Reixach J, Rialdi A, Balaseviciute U, Pinyol R, Montironi C, Haber PK, Del Río-Álvarez Á, Domingo-Sàbat M, Royo L, Akers NK, Willoughby CE, Peix J, Torres-Martin M, Puigvehi M, Cairo S, Childs M, Maibach R, Alaggio R, Czauderna P, Morland B, Losic B, Mazzaferro V, Guccione E, Sia D, Armengol C, and Llovet JM

Subjects
Humans, Animals, Mice, Cisplatin pharmacology, Cisplatin therapeutic use, DNA Methylation, Genomics, Insulin-Like Growth Factor II genetics, Hepatoblastoma drug therapy, Hepatoblastoma genetics, Hepatoblastoma pathology, Liver Neoplasms drug therapy, Liver Neoplasms genetics, Liver Neoplasms pathology
Abstract

Management of hepatoblastoma (HB), the most frequent pediatric liver cancer, is based on surgical resection and perioperative chemotherapy regimens. In this study, we aimed to identify actionable targets in HB and assess the efficacy of molecular therapies in preclinical models of HB. Paired tumor and adjacent tissues from 31 HBs and a validation set of 50 HBs were analyzed using RNA-seq, SNP, and methylation arrays. IGF2 overexpression was identified as the top targetable HB driver, present in 71% of HBs (22/31). IGF2high tumors displayed progenitor cell features and shorter recurrence-free survival. IGF2 overexpression was associated in 91% of cases with fetal promoter hypomethylation, ICR1 deregulation, 11p15.5 loss of heterozygosity or miR483-5p overexpression. The antitumor effect of xentuzumab (a monoclonal antibody targeting IGF1/2) alone or in combination with the conventional therapeutic agent cisplatin was assessed in HB cell lines, in PDX-derived HB organoids and in a xenograft HB murine model. The combination of xentuzumab with cisplatin showed strong synergistic antitumor effects in organoids and in IGF2high cell lines. In mice (n = 55), the combination induced a significant decrease in tumor volume and improved survival compared with cisplatin alone. These results suggest that IGF2 is an HB actionable driver and that, in preclinical models of HB, the combination of IGF1/2 inhibition with cisplatin induces superior antitumor effects than cisplatin monotherapy. Overall, our study provides a rationale for testing IGF2 inhibitors in combination with cisplatin in HB patients with IGF2 overexpression., (©2023 American Association for Cancer Research.)

Published
2023
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