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191 results on '"Cremer, Olaf L."'

3. Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

Author

Hendriks, Astrid, Kerkman, Priscilla F., Varkila, Meri R.J., Haitsma Mulier, Jelle L.G., Ali, Sara, ten Doesschate, Thijs, van der Vaart, Thomas W., de Haas, Carla J.C., Aerts, Piet C., Cremer, Olaf L., Bonten, Marc J.M., Nizet, Victor, Liu, George Y., Codée, Jeroen D.C., Rooijakkers, Suzan H.M., van Strijp, Jos A.G., and van Sorge, Nina M.

Published
2024
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9. Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records

Author

Vagliano, Iacopo, Schut, Martijn C., Abu-Hanna, Ameen, Dongelmans, Dave A., de Lange, Dylan W., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert-Jan, Frenzel, Tim, de Jong, Remko, Peters, Marco A.A., Kamps, Marlijn J.A., Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G.C.A., de Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G.M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, de Jager, Cornelis P.C., Hendriks, Stefaan H.A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., van den Tempel, Walter, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, de Jong, Paul, Rettig, Thijs C.D., Reuland, M.C., Arbous, Sesmu, Fleuren, Lucas M., Dam, Tariq A., Thoral, Patrick J., Lalisang, Robbert C.A., Tonutti, Michele, de Bruin, Daan P., Elbers, Paul W.G., and de Keizer, Nicolette F.

Published
2022
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12. Predicting responders to prone positioning in mechanically ventilated patients with COVID-19 using machine learning

Author

Dam, Tariq A., Roggeveen, Luca F., van Diggelen, Fuda, Fleuren, Lucas M., Jagesar, Ameet R., Otten, Martijn, de Vries, Heder J., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert-Jan, Frenzel, Tim, Dongelmans, Dave A., de Jong, Remko, Peters, Marco A. A., Kamps, Marlijn J. A., Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G. C. A., de Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G. M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, de Jager, Cornelis P. C., Hendriks, Stefaan H. A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., van den Tempel, Walter, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, de Jong, Paul, Rettig, Thijs C. D., Arbous, Sesmu, Vonk, Sebastiaan J. J., Machado, Tomas, Herter, Willem E., de Grooth, Harm-Jan, Thoral, Patrick J., Girbes, Armand R. J., Hoogendoorn, Mark, and Elbers, Paul W. G.

Published
2022
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15. Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study

Author

Peters-Sengers, Hessel, Butler, Joe M., Uhel, Fabrice, Schultz, Marcus J., Bonten, Marc J., Cremer, Olaf L., and Scicluna, Brendon P.

Subjects
Infection -- Patient outcomes -- Comparative analysis, Health care industry
Abstract

Purpose There is limited knowledge on how the source of infection impacts the host response to sepsis. We aimed to compare the host response in sepsis patients with a single, known source at admission (< 24 h) to the intensive care unit. Methods From the molecular diagnosis and risk stratification of sepsis (MARS) prospective cohort, we measured 16 plasma host response biomarkers reflective of key host response pathways in 621 sepsis patients. In a subgroup (n = 335), blood leukocyte transcriptomes were compared between the sources. Differences in clinical patient profiles and survival were compared in the whole sepsis cohort (n = 2019). Results The plasma biomarker cohort was categorized into sepsis originating from the respiratory tract (n = 334, 53.8%), abdomen (n = 159, 25.6%), urinary tract (n = 44, 7.1%), cardiovascular (n = 41, 6.6%), central nervous system (CNS) (n = 18, 2.9%), or skin (n = 25, 4%). This analysis revealed stronger inflammatory and cytokine responses, loss of vascular integrity and coagulation activation in abdominal sepsis relative to respiratory. Endothelial cell activation was prominent in urinary, cardiovascular and skin infections, while CNS infection was associated with the least host response aberrations. The leukocyte transcriptional response showed the largest overlap between abdominal and pulmonary infections (76% in common); notable differences between the sources were detected regarding hemostasis, cytokine signaling, innate and adaptive immune, and metabolic transcriptional pathways. After adjustment for confounders, the source of infection remained an independent contributor to 30-day mortality (unadjusted p = 0.001, adjusted p = 0.028). Conclusion Sepsis heterogeneity is partly explained by source-specific host response dysregulations and should be considered when selecting patients for trials testing immune modulatory drugs., Author(s): Hessel Peters-Sengers [sup.1] [sup.2], Joe M. Butler [sup.1] [sup.2], Fabrice Uhel [sup.1] [sup.2], Marcus J. Schultz [sup.3] [sup.4] [sup.5] [sup.6], Marc J. Bonten [sup.7] [sup.8], Olaf L. Cremer [sup.9], [...]

Published
2022
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16. Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response

Author

Leite, Giuseppe G. F., primary, de Brabander, Justin, additional, Michels, Erik H. A., additional, Butler, Joe M., additional, Cremer, Olaf L., additional, Scicluna, Brendon P., additional, Sweeney, Timothy E., additional, Reyes, Miguel, additional, Salomao, Reinaldo, additional, Peters-Sengers, Hessel, additional, and van der Poll, Tom, additional

Published
2024
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18. The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia

Author

Sepsis and Inflammation, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Chouchane, Osoul, Schuurman, Alex R, Reijnders, Tom D Y, Peters-Sengers, Hessel, Butler, Joe M, Uhel, Fabrice, Schultz, Marcus J, Bonten, Marc J, Cremer, Olaf L, Calfee, Carolyn S, Matthay, Michael A, Langley, Raymond J, Alipanah-Lechner, Narges, Kingsmore, Stephen F, Rogers, Angela, Weeghel, Michel van, Vaz, Frédéric M, van der Poll, Tom, Sepsis and Inflammation, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Chouchane, Osoul, Schuurman, Alex R, Reijnders, Tom D Y, Peters-Sengers, Hessel, Butler, Joe M, Uhel, Fabrice, Schultz, Marcus J, Bonten, Marc J, Cremer, Olaf L, Calfee, Carolyn S, Matthay, Michael A, Langley, Raymond J, Alipanah-Lechner, Narges, Kingsmore, Stephen F, Rogers, Angela, Weeghel, Michel van, Vaz, Frédéric M, and van der Poll, Tom

Published
2024

19. Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response

Author

Medische Staf Intensive Care, Infection & Immunity, Sepsis and Inflammation, Leite, Giuseppe G F, de Brabander, Justin, Michels, Erik H A, Butler, Joe M, Cremer, Olaf L, Scicluna, Brendon P, Sweeney, Timothy E, Reyes, Miguel, Salomao, Reinaldo, Peters-Sengers, Hessel, van der Poll, Tom, Medische Staf Intensive Care, Infection & Immunity, Sepsis and Inflammation, Leite, Giuseppe G F, de Brabander, Justin, Michels, Erik H A, Butler, Joe M, Cremer, Olaf L, Scicluna, Brendon P, Sweeney, Timothy E, Reyes, Miguel, Salomao, Reinaldo, Peters-Sengers, Hessel, and van der Poll, Tom

Published
2024

20. Biomarker patterns in patients with cardiogenic shock versus septic shock

Author

Medische Staf Intensive Care, Infection & Immunity, Peters, Elma J., Frydland, Martin S., Hassager, Christian, Bos, Lieuwe D.J., van Vught, Lonneke A., Cremer, Olaf L., Møller, Jacob E., van den Born, Bert Jan H., Vlaar, Alexander P.J., Henriques, Jose P.S., Medische Staf Intensive Care, Infection & Immunity, Peters, Elma J., Frydland, Martin S., Hassager, Christian, Bos, Lieuwe D.J., van Vught, Lonneke A., Cremer, Olaf L., Møller, Jacob E., van den Born, Bert Jan H., Vlaar, Alexander P.J., and Henriques, Jose P.S.

Published
2024

21. Examining pancreatic stone protein response in ICU-acquired bloodstream infections: a matched event analysis

Author

Infection & Immunity, Epi Infectieziekten Team 1, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Verlaan, Diede, Derde, Lennie P G, van der Poll, Tom, Bonten, Marc J M, Cremer, Olaf L, Infection & Immunity, Epi Infectieziekten Team 1, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Verlaan, Diede, Derde, Lennie P G, van der Poll, Tom, Bonten, Marc J M, and Cremer, Olaf L

Published
2024

22. Inflammatory subphenotypes previously identified in ARDS are associated with mortality at intensive care unit discharge: a secondary analysis of a prospective observational study

Author

Medische Staf Intensive Care, Infection & Immunity, Slim, Marleen A., van Amstel, Rombout B.E., Bos, Lieuwe D.J., Cremer, Olaf L., Wiersinga, W. Joost, van der Poll, Tom, van Vught, Lonneke A., Medische Staf Intensive Care, Infection & Immunity, Slim, Marleen A., van Amstel, Rombout B.E., Bos, Lieuwe D.J., Cremer, Olaf L., Wiersinga, W. Joost, van der Poll, Tom, and van Vught, Lonneke A.

Published
2024

24. Neuropsychiatric sequelae following extracorporeal membrane oxygenation in the intensive care unit

Author

Infection & Immunity, Sepsis and Inflammation, Epi Methoden Team 3, Medische Staf Intensive Care, Other research (not in main researchprogram), Pladet, Lara C A, Luijken, Kim, Donker, Dirk W, Cremer, Olaf L, Meuwese, Christiaan L, Infection & Immunity, Sepsis and Inflammation, Epi Methoden Team 3, Medische Staf Intensive Care, Other research (not in main researchprogram), Pladet, Lara C A, Luijken, Kim, Donker, Dirk W, Cremer, Olaf L, and Meuwese, Christiaan L

Published
2024

25. Two-step interpretable modeling of ICU-AIs

Author

Sub Mathematical Modeling, Mathematical Modeling, Lancia, Giacomo, Varkila, Meri, Cremer, Olaf L., Spitoni, Cristian, Sub Mathematical Modeling, Mathematical Modeling, Lancia, Giacomo, Varkila, Meri, Cremer, Olaf L., and Spitoni, Cristian

Published
2024

26. The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia

Author

Chouchane, Osoul, primary, Schuurman, Alex R., additional, Reijnders, Tom D. Y., additional, Peters-Sengers, Hessel, additional, Butler, Joe M, additional, Uhel, Fabrice, additional, Schultz, Marcus J, additional, Bonten, Marc J., additional, Cremer, Olaf L, additional, Calfee, Carolyn S, additional, Matthay, Michael A., additional, Langley, Raymond J, additional, Alipanah-Lechner, Narges, additional, Kingsmore, Stephen F, additional, Rogers, Angela, additional, Weeghel, Michel van, additional, Vaz, Frédéric M., additional, and van der Poll, Tom, additional

Published
2024
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28. Predictors for extubation failure in COVID-19 patients using a machine learning approach

Author

Fleuren, Lucas M., Dam, Tariq A., Tonutti, Michele, de Bruin, Daan P., Lalisang, Robbert C. A., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert-Jan, Frenzel, Tim, Dongelmans, Dave A., de Jong, Remko, Peters, Marco, Kamps, Marlijn J. A., Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G. C. A., de Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G. M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, de Jager, Cornelis P. C., Hendriks, Stefaan H. A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., van den Tempel, Walter, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, de Jong, Paul, Rettig, Thijs C. D., Arbous, Sesmu, Vonk, Sebastiaan J. J., Fornasa, Mattia, Machado, Tomas, Houwert, Taco, Hovenkamp, Hidde, Noorduijn Londono, Roberto, Quintarelli, Davide, Scholtemeijer, Martijn G., de Beer, Aletta A., Cinà, Giovanni, Kantorik, Adam, de Ruijter, Tom, Herter, Willem E., Beudel, Martijn, Girbes, Armand R. J., Hoogendoorn, Mark, Thoral, Patrick J., and Elbers, Paul W. G.

Published
2021
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29. The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

Author

Fleuren, Lucas M., Dam, Tariq A., Tonutti, Michele, de Bruin, Daan P., Lalisang, Robbert C. A., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert-Jan, Frenzel, Tim, Dongelmans, Dave A., de Jong, Remko, Peters, Marco, Kamps, Marlijn J. A., Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G. C. A., de Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G. M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, de Jager, Cornelis P. C., Hendriks, Stefaan H. A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., van den Tempel, Walter, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, de Jong, Paul, Rettig, Thijs C. D., Arbous, Sesmu, Vonk, Sebastiaan J. J., Fornasa, Mattia, Machado, Tomas, Houwert, Taco, Hovenkamp, Hidde, Noorduijn-Londono, Roberto, Quintarelli, Davide, Scholtemeijer, Martijn G., de Beer, Aletta A., Cina, Giovanni, Beudel, Martijn, Herter, Willem E., Girbes, Armand R. J., Hoogendoorn, Mark, Thoral, Patrick J., and Elbers, Paul W. G.

Published
2021
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33. Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case–control study.

Author

Varkila, Meri R. J., Verboom, Diana M., Derde, Lennie P. G., van der Poll, Tom, Bonten, Marc J. M., Cremer, Olaf L., de Beer, Friso M., Bos, Lieuwe D. J., Glas, Gerie J., Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T. M., Horn, Janneke, Huson, Mischa A., Juffermans, Nicole P., Schouten, Laura R. A., Scicluna, Brendon, Schultz, Marcus J., Straat, Marleen, van Vught, Lonneke A., and Wieske, Luuk

Subjects
SKIN microbiology, CROSS infection, GUT microbiome, BACTEREMIA, BLOODBORNE infections, CATHETER-related infections, DESCRIPTIVE statistics, ODDS ratio, INTENSIVE care units, CASE-control method, CONFIDENCE intervals, BIOMARKERS
Abstract

Background: Impaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream infections during critical illness. We aimed to determine the relative importance of gut translocation as a source for ICU-acquired enterococcal bacteremia of unknown origin. Methods: We conducted a nested case–control study in two mixed medical-surgical tertiary ICUs in the Netherlands among patients enrolled between 2011 and 2018. We selected 72 cases with ICU-acquired bacteremia due to enterococci (which are known gastrointestinal tract commensals) and 137 matched controls with bacteremia due to coagulase-negative staphylococci (CoNS) (which are of non-intestinal origin). We measured intestinal fatty acid-binding protein, trefoil factor-3, and citrulline 48 h before bacteremia onset. A composite measure for Gut Barrier Injury (GBI) was calculated as the sum of standardized z-scores for each biomarker plus a clinical gastrointestinal failure score. Results: No single biomarker yielded statistically significant differences between cases and controls. Median composite GBI was higher in cases than in controls (0.58, IQR − 0.36–1.69 vs. 0.32, IQR − 0.53–1.57, p = 0.33) and higher composite measures of GBI correlated with higher disease severity and ICU mortality (p < 0.001). In multivariable analysis, higher composite GBI was not significantly associated with increased occurrence of enterococcal bacteremia relative to CoNS bacteremia (adjusted OR 1.12 95% CI 0.93–1.34, p = 0.22). Conclusions: We could not demonstrate an association between biomarkers of gastrointestinal barrier dysfunction and an increased occurrence of bacteremia due to gut compared to skin flora during critical illness, suggesting against bacterial translocation as a major vector for acquisition of nosocomial bloodstream infections in the ICU. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Some Patients Are More Equal Than Others: Variation in Ventilator Settings for Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

Author

Dam, Tariq A., de Grooth, Harm-Jan, Klausch, Thomas, Fleuren, Lucas M., de Bruin, Daan P., Entjes, Robert, Rettig, Thijs C. D., Dongelmans, Dave A., Boelens, Age D., Rigter, Sander, Hendriks, Stefaan H. A., de Jong, Remko, Kamps, Marlijn J. A, Peters, Marco, Karakus, A., Gommers, Diederik, Ramnarain, Dharmanand, Wils, Evert-Jan, Achterberg, Sefanja, Nowitzky, Ralph, van den Tempel, Walter, de Jager, Cornelis P. C., Nooteboom, Fleur G. C. A., Oostdijk, Evelien, Koetsier, Peter, Cornet, Alexander D., Reidinga, Auke C., de Ruijter, Wouter, Bosman, Rob J., Frenzel, Tim, Urlings-Strop, Louise C., de Jong, Paul, Smit, Ellen G. M., Cremer, Olaf L., Mehagnoul-Schipper, D. Jannet, Faber, Harald J., Lens, Judith, Brunnekreef, Gert B., Festen-Spanjer, Barbara, Dormans, Tom, Dijkstra, Annemieke, Simons, Bram, Rijkeboer, A. A., Arbous, Sesmu, Aries, Marcel, Beukema, Menno, Pretorius, Daniël, van Raalte, Rutger, van Tellingen, Martijn, Gritters van den Oever, Niels C., Lalisang, Robbert C. A., Tonutti, Michele, Girbes, Armand R. J., Hoogendoorn, Mark, Thoral, Patrick J., and Elbers, Paul W. G.

Published
2021
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37. Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients

Author

Smit, Jasper M., Exterkate, Lotte, Van Tienhoven, Arne J., Haaksma, Mark E., Heldeweg, Micah L.A., Fleuren, Lucas, Thoral, Patrick, Dam, Tariq A., Heunks, Leo M.A., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert Jan, Frenzel, Tim, Vlaar, Alexander P., Dongelmans, Dave A., De Jong, Remko, Peters, Marco, Kamps, Marlijn J.A., Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G.C.A., De Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G.M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, De Jager, Cornelis P.C., Hendriks, Stefaan H.A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., Van Den Tempel, Walter, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, De Jong, Paul, Rettig, Thijs C.D., Arbous, Sesmu, Vonk, Bas, Machado, Tomas, Girbes, Armand R.J., Sieswerda, Elske, Elbers, Paul W.G., Tuinman, Pieter R., Intensive care medicine, Radiology and nuclear medicine, Anesthesiology, Internal medicine, ACS - Diabetes & metabolism, ACS - Microcirculation, Amsterdam Cardiovascular Sciences, Cardio-thoracic surgery, General practice, AII - Infectious diseases, Medical Microbiology and Infection Prevention, ACS - Pulmonary hypertension & thrombosis, Intensive Care Medicine, APH - Quality of Care, Graduate School, AII - Cancer immunology, CCA - Cancer biology and immunology, and Intensive Care

Subjects
catheter-related infections, Catheterization, Central Venous, Critical Illness, Incidence, Other Research Radboud Institute for Health Sciences [Radboudumc 0], COVID-19, Critical Care and Intensive Care Medicine, Central venous catheters, All institutes and research themes of the Radboud University Medical Center, Risk Factors, Emergency Medicine, Humans, Retrospective Studies, intensive care
Abstract

Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.

Published
2022

38. Glycan-specific IgM is critical for human immunity toStaphylococcus aureus

Author

Hendriks, Astrid, primary, Kerkman, Priscilla F., additional, Varkila, Meri R.J., additional, Haitsma-Mulier, Jelle L.G., additional, Ali, Sara, additional, ten Doesschate, Thijs, additional, van der Vaart, Thomas W., additional, de Haas, Carla J.C., additional, Aerts, Piet C., additional, Cremer, Olaf L., additional, Bonten, Marc J.M., additional, Nizet, Victor, additional, Liu, George Y., additional, Codée, Jeroen D.C., additional, Rooijakkers, Suzan H.M., additional, van Strijp, Jos A.G., additional, and van Sorge, Nina M., additional

Published
2023
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41. Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications

Author

de Mul, Nikki, primary, Verlaan, Diede, additional, Ruurda, Jelle P, additional, van Grevenstein, Wilhelmina M U, additional, Hagendoorn, Jeroen, additional, de Borst, Gert-Jan, additional, Vriens, Menno R, additional, de Bree, Remco, additional, Zweemer, Ronald P, additional, Vogely, Charles, additional, Haitsma Mulier, Jelle L G, additional, Vernooij, Lisette M, additional, Reitsma, Johannes B, additional, de Zoete, Marcel R, additional, Top, Janetta, additional, Kluijtmans, Jan A J, additional, Hoefer, Imo E, additional, Noordzij, Peter, additional, Rettig, Thijs, additional, Marsman, Marije, additional, de Smet, Anne Marie G A, additional, Derde, Lennie, additional, van Waes, Judith, additional, Rijsdijk, Mienke, additional, Schellekens, Willem Jan M, additional, Bonten, Marc J M, additional, Slooter, Arjen J C, additional, and Cremer, Olaf L, additional

Published
2023
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42. Interrater agreement in classifying infections during extracorporeal membrane oxygenation

Author

Verkerk, Karlijn, Pladet, Lara C.A., Meuwese, Christiaan L., Donker, Dirk W., Derde, Lennie P.G., Cremer, Olaf L., Verkerk, Karlijn, Pladet, Lara C.A., Meuwese, Christiaan L., Donker, Dirk W., Derde, Lennie P.G., and Cremer, Olaf L.

Abstract

Infectious complications are common during extracorporeal membrane oxygenation (ECMO) and may negatively impact outcomes. However, there is considerable variation in the reported rates of incidence, which hampers the use of infections as a quality benchmark for ECMO centers. To assess the contributing role of poor interrater agreement, three independent raters reviewed medical records from all intensive care unit (ICU) patients who received ECMO for >24 h in our tertiary center between October 2019 and October 2021 for suspected episodes of infection, which were rated based on their date of onset and presumed site/diagnosis. To establish a gold standard, any discrepancies were resolved using an expert panel consisting of two intensivists/infectious disease specialists. During 83 ECMO-runs in 77 patients, we observed a total of 62 adjudicated infectious episodes (incidence rate 62, 95% CI: 48–80, per 1000 days at risk). Among 81 episodes suspected by at least one observer, 66 (81%) were identified by two, and only 44 (54%) by all three raters, resulting in Fleiss’ kappa of 0.10 (95% CI: 0.00–0.19; slight agreement). However, if raters concurred regarding infection onset, subsequent agreement on infection site was good (concordance 89%; kappa 0.85, 95% CI: 0.72–0.98; near perfect agreement). In conclusion, adjudication of infectious episodes during ECMO is associated with poor interrater agreement regarding occurrence—but not site—of infection. This finding might partially explain the significant disparities observed in reported infection rates during ECMO, emphasizing the need for caution when interpreting infection data in this particular population due to the potential for inherent measurement error.

Published
2023

43. Prognostic models for mortality risk in patients requiring ECMO

Author

Pladet, Lara C.A., Barten, Jaimie M.M., Vernooij, Lisette M., Kraemer, Carlos V.Elzo, Bunge, Jeroen J.H., Scholten, Erik, Montenij, Leon J., Kuijpers, Marijn, Donker, Dirk W., Cremer, Olaf L., Meuwese, Christiaan L., Pladet, Lara C.A., Barten, Jaimie M.M., Vernooij, Lisette M., Kraemer, Carlos V.Elzo, Bunge, Jeroen J.H., Scholten, Erik, Montenij, Leon J., Kuijpers, Marijn, Donker, Dirk W., Cremer, Olaf L., and Meuwese, Christiaan L.

Abstract

Purpose: To provide an overview and evaluate the performance of mortality prediction models for patients requiring extracorporeal membrane oxygenation (ECMO) support for refractory cardiocirculatory or respiratory failure. Methods: A systematic literature search was undertaken to identify studies developing and/or validating multivariable prediction models for all-cause mortality in adults requiring or receiving veno-arterial (V-A) or veno-venous (V-V) ECMO. Estimates of model performance (observed versus expected (O:E) ratio and c-statistic) were summarized using random effects models and sources of heterogeneity were explored by means of meta-regression. Risk of bias was assessed using the Prediction model Risk Of BiAS Tool (PROBAST). Results: Among 4905 articles screened, 96 studies described a total of 58 models and 225 external validations. Out of all 58 models which were specifically developed for ECMO patients, 14 (24%) were ever externally validated. Discriminatory ability of frequently validated models developed for ECMO patients (i.e., SAVE and RESP score) was moderate on average (pooled c-statistics between 0.66 and 0.70), and comparable to general intensive care population-based models (pooled c-statistics varying between 0.66 and 0.69 for the Simplified Acute Physiology Score II (SAPS II), Acute Physiology and Chronic Health Evaluation II (APACHE II) score and Sequential Organ Failure Assessment (SOFA) score). Nearly all models tended to underestimate mortality with a pooled O:E > 1. There was a wide variability in reported performance measures of external validations, reflecting a large between-study heterogeneity. Only 1 of the 58 models met the generally accepted Prediction model Risk Of BiAS Tool criteria of good quality. Importantly, all predicted outcomes were conditional on the fact that ECMO support had already been initiated, thereby reducing their applicability for patient selection in clinical practice. Conclusions: A large number of mo

Published
2023

45. Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes

Author

Infection & Immunity, Medische Staf Intensive Care, van Amstel, Rombout B E, Kennedy, Jason N, Scicluna, Brendon P, Bos, Lieuwe D J, Peters-Sengers, Hessel, Butler, Joe M, Cano-Gamez, Eddie, Knight, Julian C, Vlaar, Alexander P J, Cremer, Olaf L, Angus, Derek C, van der Poll, Tom, Seymour, Christopher W, van Vught, Lonneke A, MARS Consortium, Infection & Immunity, Medische Staf Intensive Care, van Amstel, Rombout B E, Kennedy, Jason N, Scicluna, Brendon P, Bos, Lieuwe D J, Peters-Sengers, Hessel, Butler, Joe M, Cano-Gamez, Eddie, Knight, Julian C, Vlaar, Alexander P J, Cremer, Olaf L, Angus, Derek C, van der Poll, Tom, Seymour, Christopher W, van Vught, Lonneke A, and MARS Consortium

Published
2023

47. Interrater agreement in classifying infections during extracorporeal membrane oxygenation

Author

Sepsis and Inflammation, Infection & Immunity, Medische Staf Intensive Care, Other research (not in main researchprogram), UMC Utrecht, Verkerk, Karlijn, Pladet, Lara C.A., Meuwese, Christiaan L., Donker, Dirk W., Derde, Lennie P.G., Cremer, Olaf L., Sepsis and Inflammation, Infection & Immunity, Medische Staf Intensive Care, Other research (not in main researchprogram), UMC Utrecht, Verkerk, Karlijn, Pladet, Lara C.A., Meuwese, Christiaan L., Donker, Dirk W., Derde, Lennie P.G., and Cremer, Olaf L.

Published
2023

48. Advanced glycation end products for preoperative frailty screening in older cardiac surgery patients

Author

MS Geriatrie, Circulatory Health, Onderzoek, Medische Staf Intensive Care, Infection & Immunity, Smoor, Rosa M, van Dongen, Eric P A, Verwijmeren, Lisa, Emmelot-Vonk, Mariëlle H, Vernooij, Lisette M, Cremer, Olaf L, Noordzij, Peter G, MS Geriatrie, Circulatory Health, Onderzoek, Medische Staf Intensive Care, Infection & Immunity, Smoor, Rosa M, van Dongen, Eric P A, Verwijmeren, Lisa, Emmelot-Vonk, Mariëlle H, Vernooij, Lisette M, Cremer, Olaf L, and Noordzij, Peter G

Published
2023

49. Prognostic models for mortality risk in patients requiring ECMO

Author

Sepsis and Inflammation, Infection & Immunity, Onderzoek, Onderzoek Heart at Risk, Medische Staf Intensive Care, Other research (not in main researchprogram), Pladet, Lara C.A., Barten, Jaimie M.M., Vernooij, Lisette M., Kraemer, Carlos V.Elzo, Bunge, Jeroen J.H., Scholten, Erik, Montenij, Leon J., Kuijpers, Marijn, Donker, Dirk W., Cremer, Olaf L., Meuwese, Christiaan L., Sepsis and Inflammation, Infection & Immunity, Onderzoek, Onderzoek Heart at Risk, Medische Staf Intensive Care, Other research (not in main researchprogram), Pladet, Lara C.A., Barten, Jaimie M.M., Vernooij, Lisette M., Kraemer, Carlos V.Elzo, Bunge, Jeroen J.H., Scholten, Erik, Montenij, Leon J., Kuijpers, Marijn, Donker, Dirk W., Cremer, Olaf L., and Meuwese, Christiaan L.

Published
2023

50. Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications

Author

AIOS Anesthesiologie, Epi Infectieziekten Team 1, Infection & Immunity, MS CGO, Cancer, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Heelkunde Opleiding, MS Hoofd-Hals Chirurgische Oncologie, MS Gynaecologische Oncologie, MS Orthopaedie Algemeen, Onderzoek, Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, MMB Research line 2, Medische Microbiologie, JC onderzoeksprogramma Infectieziekten, Centraal Diagnostisch Laboratorium, Medische staf Anesthesiologie, DVF Medisch, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, AIOS Psychiatrie, Brain, de Mul, Nikki, Verlaan, Diede, Ruurda, Jelle P, van Grevenstein, Wilhelmina M U, Hagendoorn, Jeroen, de Borst, Gert-Jan, Vriens, Menno R, de Bree, Remco, Zweemer, Ronald P, Vogely, Charles, Haitsma Mulier, Jelle L G, Vernooij, Lisette M, Reitsma, Johannes B, de Zoete, Marcel R, Top, Janetta, Kluijtmans, Jan A J, Hoefer, Imo E, Noordzij, Peter, Rettig, Thijs, Marsman, Marije, de Smet, Anne Marie G A, Derde, Lennie, van Waes, Judith, Rijsdijk, Mienke, Schellekens, Willem Jan M, Bonten, Marc J M, Slooter, Arjen J C, Cremer, Olaf L, AIOS Anesthesiologie, Epi Infectieziekten Team 1, Infection & Immunity, MS CGO, Cancer, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Heelkunde Opleiding, MS Hoofd-Hals Chirurgische Oncologie, MS Gynaecologische Oncologie, MS Orthopaedie Algemeen, Onderzoek, Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, MMB Research line 2, Medische Microbiologie, JC onderzoeksprogramma Infectieziekten, Centraal Diagnostisch Laboratorium, Medische staf Anesthesiologie, DVF Medisch, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, AIOS Psychiatrie, Brain, de Mul, Nikki, Verlaan, Diede, Ruurda, Jelle P, van Grevenstein, Wilhelmina M U, Hagendoorn, Jeroen, de Borst, Gert-Jan, Vriens, Menno R, de Bree, Remco, Zweemer, Ronald P, Vogely, Charles, Haitsma Mulier, Jelle L G, Vernooij, Lisette M, Reitsma, Johannes B, de Zoete, Marcel R, Top, Janetta, Kluijtmans, Jan A J, Hoefer, Imo E, Noordzij, Peter, Rettig, Thijs, Marsman, Marije, de Smet, Anne Marie G A, Derde, Lennie, van Waes, Judith, Rijsdijk, Mienke, Schellekens, Willem Jan M, Bonten, Marc J M, Slooter, Arjen J C, and Cremer, Olaf L

Published
2023

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