47 results on '"Cools, Filip"'
Search Results
2. Predictive Performance of a Gentamicin Pharmacokinetic Model in Term Neonates with Perinatal Asphyxia Undergoing Controlled Therapeutic Hypothermia
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van der Veer, Marlotte A. A., de Haan, Timo R., Franken, Linda G. W., Groenendaal, Floris, Dijk, Peter H., de Boode, Willem P., Simons, Sinno, Dijkman, Koen P., van Straaten, Henrica L.M., Rijken, Monique, Cools, Filip, Nuytemans, Debbie H. G. M., van Kaam, Anton H., Bijleveld, Yuma. A., Mathôt, Ron A. A., Brouwer, Mieke J., van den Broek, Marcel P., Rademaker, Carin M. A., Liem, Djien, Steiner, Katerina, Bos, Annelies A., Tollenaer, S. M. Mulder-de, Jebbink-Akkerman, L. J. M. Groot, Sonnaert, Michel, and Camfferman, Fleur Anne
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- 2024
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3. Association Between Seizures and Neurodevelopmental Outcome at Two and Five Years in Asphyxiated Newborns With Therapeutic Hypothermia
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van den Akker, Chris H.P., de Boode, Willem P., Cools, Filip, ter Horst, Henk J., Dijkman, Koen P., Groenendaal, Floris, de Haan, Timo R., Simons, Sinno H.P., Steggerda, Sylke J., Mulder-Tollenaer, Suzanne, Zecic, Alexandra, Langeslag, Juliette F., Onland, Wes, de Vries, Linda S., and van Kaam, Anton H.
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- 2024
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4. Effect of Systemic Hydrocortisone on Brain Abnormalities and Regional Brain Volumes in Ventilator-dependent Infants Born Preterm: Substudy of the SToP-BPD Study
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Halbmeijer, Nienke M., Onland, Wes, Dudink, Jeroen, Cools, Filip, Debeer, Anne, van Kaam, Anton H., Benders, Manon J.N.L., and van der Aa, Niek E.
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- 2024
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5. Neurally adjusted ventilatory assist in preterm infants: A systematic review and meta‐analysis
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Lefevere, Julie, primary, van Delft, Brenda, additional, Decaluwe, Wim, additional, Derriks, Frank, additional, and Cools, Filip, additional
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- 2024
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6. Non-invasive neurally adjusted ventilatory assist in preterm infants with RDS: effect of changing NAVA levels
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Lefevere, Julie, Van Delft, Brenda, Vervoort, Michel, Cools, Wilfried, and Cools, Filip
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- 2022
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7. Consultation of parents and healthcare professionals in end-of-life decision-making for neonates and infants: a population-level mortality follow-back physician survey
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Dombrecht, Laure, Cools, Filip, Cohen, Joachim, Deliens, Luc, Goossens, Linde, Naulaers, Gunnar, Beernaert, Kim, and Chambaere, Kenneth
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- 2022
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8. Effect of Systemic Hydrocortisone on Brain Abnormalities and Regional Brain Volumes in Ventilator-dependent Infants Born Preterm: Substudy of the SToP-BPD Study
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MS Neonatologie, Brain, Child Health, Developmental Disorders, Circulatory Health, Halbmeijer, Nienke M., Onland, Wes, Dudink, Jeroen, Cools, Filip, Debeer, Anne, van Kaam, Anton H., Benders, Manon J.N.L., van der Aa, Niek E., MS Neonatologie, Brain, Child Health, Developmental Disorders, Circulatory Health, Halbmeijer, Nienke M., Onland, Wes, Dudink, Jeroen, Cools, Filip, Debeer, Anne, van Kaam, Anton H., Benders, Manon J.N.L., and van der Aa, Niek E.
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- 2024
9. Association between seizures and neurodevelopmental outcome at two- and five years in asphyxiated newborns with therapeutic hypothermia
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Langeslag, J.F., primary, Onland, W., additional, Groenendaal, F., additional, de Vries, L.S., additional, van Kaam, A.H., additional, de Haan, T.R., additional, van den Akker, Chris H.P., additional, de Boode, Willem P., additional, Cools, Filip, additional, ter Horst, Henk J., additional, Dijkman, Koen P., additional, Groenendaal, Floris, additional, de Haan, Timo R., additional, Simons, Sinno H.P., additional, Steggerda, Sylke J., additional, Mulder-Tollenaer, Suzanne, additional, and Zecic, Alexandra, additional
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- 2024
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10. Non-pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates
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Pirlotte, Sofie, additional, Beeckman, Katrien, additional, Ooms, Isabel, additional, and Cools, Filip, additional
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- 2024
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11. Cause of death and making end-of-life decisions in preterm infants has not changed over time: A mortality follow-back survey.
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Goossens, Linde, Dombrecht, Laure, Chambaere, Kenneth, Beernaert, Kim, and Cools, Filip
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PREMATURE infants ,CAUSES of death ,DECISION making ,MORTALITY ,ATTITUDE change (Psychology) - Abstract
Aim: This study aimed to evaluate changes over time in cause of death and making end-of-life decisions in preterm infants. Methods: A follow-back survey was conducted of all preterm infants who died between September 2016 and December 2017 in Flanders and Brussels, Belgium. Cause of death was obtained from the death certificate and information on end-of-life decisions (ELDs) through an anonymous questionnaire of the certifying physician. Results were compared with a previous study performed between August 1999 and July 2000. Results: In the cohort 1999-2000 and 2016-2017, respectively, 150 and 135 deaths were included. A significantly higher proportion of infants born before 26 weeks of gestation was found in the 2016-2017 cohort (53% vs. 24% in 1999-2000, p < 0.001). Extreme immaturity (<26 weeks) remained the most prevalent cause with a significant increase in the 2016-2017 cohort (48% vs. 28% in 1999-2000, p < 0.001). The overall prevalence of ELDs was similar across study periods (61%). Non-treatment decisions remained the most common ELD (36% and 37%). Conclusion: Infants born at the limits of viability have become more prevalent among infant deaths, possibly due to a change in attitude towards periviable births. Neither the process of making ELDs nor the cause of death has changed over time. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Population pharmacokinetics of vancomycin in term neonates with perinatal asphyxia treated with therapeutic hypothermia.
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van der Veer, Marlotte A. A., de Haan, Timo R., Franken, Linda G. W., van Hest, Reinier M., Groenendaal, Floris, Dijk, Peter H., de Boode, Willem P., Simons, Sinno, Dijkman, Koen P., van Straaten, Henrica L. M., Rijken, Monique, Cools, Filip, Nuytemans, Debbie H. G. M., van Kaam, Anton H., Bijleveld, Yuma A., and Mathôt, Ron A. A.
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THERAPEUTIC hypothermia ,ASPHYXIA neonatorum ,NEWBORN infants ,VANCOMYCIN ,PHARMACOKINETICS ,BIRTH weight - Abstract
Aims: Little is known about the population pharmacokinetics (PPK) of vancomycin in neonates with perinatal asphyxia treated with therapeutic hypothermia (TH). We aimed to describe the PPK of vancomycin and propose an initial dosing regimen for the first 48 h of treatment with pharmacokinetic/pharmacodynamic target attainment. Methods: Neonates with perinatal asphyxia treated with TH were included from birth until Day 6 in a multicentre prospective cohort study. A vancomycin PPK model was constructed using nonlinear mixed‐effects modelling. The model was used to evaluate published dosing guidelines with regard to pharmacokinetic/pharmacodynamic target attainment. The area under the curve/minimal inhibitory concentration ratio of 400–600 mg*h/L was used as target range. Results: Sixteen patients received vancomycin (median gestational age: 41 [range: 38–42] weeks, postnatal age: 4.4 [2.5–5.5] days, birth weight: 3.5 [2.3–4.7] kg), and 112 vancomycin plasma concentrations were available. Most samples (79%) were collected during the rewarming and normothermic phase, as vancomycin was rarely initiated during the hypothermic phase due to its nonempirical use. An allometrically scaled 1‐compartment model showed the best fit. Vancomycin clearance was 0.17 L/h, lower than literature values for term neonates of 3.5 kg without perinatal asphyxia (range: 0.20–0.32 L/h). Volume of distribution was similar. Published dosing regimens led to overexposure within 24 h of treatment. A loading dose of 10 mg/kg followed by 24 mg/kg/day in 4 doses resulted in target attainment. Conclusion: Results of this study suggest that vancomycin clearance is reduced in term neonates with perinatal asphyxia treated with TH. Lower dosing regimens should be considered followed by model‐informed precision dosing. [ABSTRACT FROM AUTHOR]
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- 2024
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13. The Use of Standardized Solutions Instead of Individualized Prescriptions for Parenteral Nutrition on the Neonatal Intensive Care Unit in UZ Brussel: A Feasibility Study.
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Batteux, Melanie, Meers, Garmt, Fien, Bockstal, Cortoos, Pieter-Jan, and Cools, Filip
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MEDICAL protocols ,PARENTERAL feeding ,PARENTERAL solutions ,FOOD consumption ,CRITICALLY ill ,PATIENTS ,NEONATAL intensive care units ,PILOT projects ,NEONATAL intensive care ,RETROSPECTIVE studies ,NUTRITIONAL requirements ,PHYSICIAN practice patterns ,MEDICAL records ,ACQUISITION of data ,GESTATIONAL age ,DRUGS ,INDIVIDUALIZED medicine - Abstract
For parenteral nutrition (PN) of newborns, the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) 2018 guidelines recommend standardized solutions over individual PN (IPN) solutions for most patients. This retrospective study assessed if a shift from IPN to standardized PN was feasible at the UZ Brussel. Using prescription data of 145 neonates, we calculated the nutrient provision for IPN and for standardized PN of the same volumes. We compared the macronutrient intakes with ESPGHAN 2018 recommendations to assess the feasibility. For neonates of a gestational age (GA) <32 or >36 weeks, standardized PN reached recommendations as least as fast as IPN. For neonates with a GA of 32 to 36 weeks, the administration protocol requires further adjustments as amino acid provision was lacking compared to IPN. Overall, the results support the feasibility of a shift from IPN to standardized PN at the UZ Brussel. [ABSTRACT FROM AUTHOR]
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- 2024
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14. End-of-life decisions in neonates and infants: a nationwide mortality follow-back survey.
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Dombrecht, Laure, Beernaert, Kim, Chambaere, Kenneth, Cools, Filip, Goossens, Linde, Naulaers, Gunnar, Cornette, Luc, Laroche, Sabrina, Theyskens, Claire, Vandeputte, Christine, Van de Broek, Hilde, Joachim Cohen, and Deliens, Luc
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- 2024
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15. The Use of Standardized Solutions Instead of Individualized Prescriptions for Parenteral Nutrition on the Neonatal Intensive Care Unit in UZ Brussel: A Feasibility Study
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Batteux, Melanie, primary, Meers, Garmt, additional, Fien, Bockstal, additional, Cortoos, Pieter-Jan, additional, and Cools, Filip, additional
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- 2023
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16. The use of a T-piece resuscitator in the newborn infants
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Van Delft, Brenda, Fauconnier, Gwenn, Cools, Filip, Lefevere, Julie Sara, Van Delft, Christel, Clinical sciences, Faculty of Medicine and Pharmacy, Growth and Development, Neonatology, and UZB Other
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- 2023
17. Effect of systemic hydrocortisone in ventilated preterm infants on parent-reported behavioural outcomes at 2 years' corrected age
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SToP-BPD Study Group, Halbmeijer, Nienke Marjolein, Onland, Wes, Cools, Filip, Swarte, Renate M, van der Heide-Jalving, Marja, Dijk, Peter, Mulder-de Tollenaer, Susanne, Tan, Ratna N G B, Mohns, Thilo, Bruneel, Els, van Heijst, Arno F J, Kramer, Boris, Debeer, Anne, van Weissenbruch, Mirjam M, Marechal, Yoann, Blom, Henry, Plaskie, Katleen, Offringa, Martin, van Wassenaer-Leemhuis, Aleid G, van Kaam, Anton H, Aarnoudse-Moens, Cornelieke S H, Neonatology, Brussels Heritage Lab, UZB Other, Clinical sciences, Growth and Development, STOP-BPD Study Group, RS: MHeNs - R3 - Neuroscience, RS: GROW - R4 - Reproductive and Perinatal Medicine, and MUMC+: MA Medische Staf Kindergeneeskunde (9)
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BIRTH ,MORTALITY ,SCHOOL-AGE ,MULTICENTER ,Obstetrics and Gynecology ,General Medicine ,BRONCHOPULMONARY DYSPLASIA ,THERAPY ,neonatology ,DEXAMETHASONE ,Pediatrics, Perinatology and Child Health ,SURVIVAL ,Human medicine ,Pediatrics, Perinatology, and Child Health ,CHILDREN BORN ,Child development ,INITIATED 7 - Abstract
ObjectiveTo report the parent-reported behavioural outcomes of infants included in the Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants study at 2 years’ corrected age (CA).DesignRandomised placebo-controlled trial.SettingDutch and Belgian neonatal intensive care units.PatientsInfants born InterventionInfants were randomly assigned to a 22-day course of systemic hydrocortisone (cumulative dose 72.5 mg/kg; n=182) or placebo (n=190).Main outcome measuresParent-reported behavioural outcomes at 2 years’ CA assessed with the Child Behavior Checklist (CBCL 1½−5).ResultsParents completed the CBCL of 183 (70% (183/262)) infants (hydrocortisone group, n=96; placebo group, n=87). Multiple imputation was used to account for missing data. Infants with critically elevated T-scores (>55) were found in 22.9%, 19.1% and 29.4% of infants for total, internalising and externalising problems, respectively; these scores were not significantly different between groups (mean difference −1.52 (95% CI −4.00 to 0.96), −2.40 (95% CI −4.99 to 0.20) and −0.81 (95% CI −3.40 to 1.77), respectively). In the subscales, we found a significantly lower T-score for anxiety problems in the hydrocortisone group (mean difference −1.26, 95% CI −2.41 to –0.12).ConclusionThis study found high rates of behaviour problems at 2 years’ CA following very preterm birth, but these problems were not associated with hydrocortisone treatment initiated between 7 and 14 days after birth in ventilated preterm infants.Trial registration numberNTR2768; EudraCT 2010-023777-19.
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- 2023
18. Survey of transfusion practices in preterm infants in Europe
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Neonatal Transfusion Network, Scrivens, Alexandra, Reibel, Nora Johanna, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico, New, Helen V, Dame, Christof, Fijnvandraat, Karin, Deschmann, Emöke, Aguar, Marta, Braekke, Kristin, Cardona, Francesco Stefano, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Lozar, Jana, Matasova, Katarina, Muehlbacher, Tobias, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph, Fustolo-Gunnink, Suzanne, Brussels Heritage Lab, UZB Other, Clinical sciences, Growth and Development, Neonatology, Paediatric Haematology, AII - Infectious diseases, and ARD - Amsterdam Reproduction and Development
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data collection ,Epidemiology ,Pediatrics, Perinatology and Child Health ,Child Health ,Obstetrics and Gynecology ,General Medicine ,Pediatrics, Perinatology, and Child Health ,Healthcare Disparities ,neonatology - Abstract
BackgroundPreterm infants commonly receive red blood cell (RBC), platelet and fresh frozen plasma (FFP) transfusions. The aim of this Neonatal Transfusion Network survey was to describe current transfusion practices in Europe and to compare our findings to three recent randomised controlled trials to understand how clinical practice relates to the trial data.MethodsFrom October to December 2020, we performed an online survey among 597 neonatal intensive care units (NICUs) caring for infants with a gestational age (GA) of ResultsResponses from 343 NICUs (response rate: 57%) are presented and showed substantial variation in clinical practice. For RBC transfusions, 70% of NICUs transfused at thresholds above the restrictive thresholds tested in the recent trials and 22% below the restrictive thresholds. For platelet transfusions, 57% of NICUs transfused at platelet count thresholds above 25×109/L in non-bleeding infants of GA of 9/L threshold was associated with a lower risk of harm in a recent trial. FFP transfusions were administered for coagulopathy without active bleeding in 39% and for hypotension in 25% of NICUs. Transfusion volume, duration and rate varied by factors up to several folds between NICUs.ConclusionsTransfusion thresholds and aspects of administration vary widely across European NICUs. In general, transfusion thresholds used tend to be more liberal compared with data from recent trials supporting the use of more restrictive thresholds. Further research is needed to identify the barriers and enablers to incorporation of recent trial findings into neonatal transfusion practice.
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- 2023
19. Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Term Asphyxiated Neonates during Controlled Therapeutic Hypothermia
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van der Veer, Marlotte A. A., primary, de Haan, Timo R., additional, Franken, Linda G. W., additional, Hodiamont, Caspar J., additional, Groenendaal, Floris, additional, Dijk, Peter H., additional, de Boode, Willem P., additional, Simons, Sinno, additional, Dijkman, Koen P., additional, van Straaten, Henrica L. M., additional, Rijken, Monique, additional, Cools, Filip, additional, Nuytemans, Debbie H. G. M., additional, van Kaam, Anton H., additional, Bijleveld, Yuma A., additional, Mathôt, Ron A. A., additional, Brouwer, Mieke J., additional, van den Broek, Marcel P., additional, Rademaker, Carin M. A., additional, Liem, Djien, additional, Steiner, Katerina, additional, Simons, Sinno H. P., additional, Bos, Annelies A., additional, Mulder-de Tollenaer, S. M., additional, Jebbink-Akkerman, L. J. M. Groot, additional, Sonnaert, Michel, additional, and Camfferman, Fleur Anne, additional
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- 2023
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20. Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Term Asphyxiated Neonates during Controlled Therapeutic Hypothermia
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MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, van der Veer, Marlotte A A, de Haan, Timo R, Franken, Linda G W, Hodiamont, Caspar J, Groenendaal, Floris, Dijk, Peter H, de Boode, Willem P, Simons, Sinno, Dijkman, Koen P, van Straaten, Henrica L M, Rijken, Monique, Cools, Filip, Nuytemans, Debbie H G M, van Kaam, Anton H, Bijleveld, Yuma A, Mathôt, Ron A A, MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, van der Veer, Marlotte A A, de Haan, Timo R, Franken, Linda G W, Hodiamont, Caspar J, Groenendaal, Floris, Dijk, Peter H, de Boode, Willem P, Simons, Sinno, Dijkman, Koen P, van Straaten, Henrica L M, Rijken, Monique, Cools, Filip, Nuytemans, Debbie H G M, van Kaam, Anton H, Bijleveld, Yuma A, and Mathôt, Ron A A
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- 2023
21. Survey of transfusion practices in preterm infants in Europe
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Scrivens, Alexandra; https://orcid.org/0000-0002-3429-8007, Reibel, Nora Johanna; https://orcid.org/0000-0002-6412-4606, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico; https://orcid.org/0000-0002-3513-5066, New, Helen V, Dame, Christof, Fijnvandraat, Karin, Deschmann, Emöke, Aguar, Marta, Brække, Kristin, Cardona, Francesco Stefano; https://orcid.org/0000-0002-9993-617X, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Lozar, Jana, Matasova, Katarina, Muehlbacher, Tobias; https://orcid.org/0000-0001-8661-9645, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph; https://orcid.org/0000-0001-7965-4637, Fustolo-Gunnink, Suzanne, Neonatal Transfusion Network, Scrivens, Alexandra; https://orcid.org/0000-0002-3429-8007, Reibel, Nora Johanna; https://orcid.org/0000-0002-6412-4606, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico; https://orcid.org/0000-0002-3513-5066, New, Helen V, Dame, Christof, Fijnvandraat, Karin, Deschmann, Emöke, Aguar, Marta, Brække, Kristin, Cardona, Francesco Stefano; https://orcid.org/0000-0002-9993-617X, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Lozar, Jana, Matasova, Katarina, Muehlbacher, Tobias; https://orcid.org/0000-0001-8661-9645, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph; https://orcid.org/0000-0001-7965-4637, Fustolo-Gunnink, Suzanne, and Neonatal Transfusion Network
- Abstract
BACKGROUND Preterm infants commonly receive red blood cell (RBC), platelet and fresh frozen plasma (FFP) transfusions. The aim of this Neonatal Transfusion Network survey was to describe current transfusion practices in Europe and to compare our findings to three recent randomised controlled trials to understand how clinical practice relates to the trial data. METHODS From October to December 2020, we performed an online survey among 597 neonatal intensive care units (NICUs) caring for infants with a gestational age (GA) of <32 weeks in 18 European countries. RESULTS Responses from 343 NICUs (response rate: 57%) are presented and showed substantial variation in clinical practice. For RBC transfusions, 70% of NICUs transfused at thresholds above the restrictive thresholds tested in the recent trials and 22% below the restrictive thresholds. For platelet transfusions, 57% of NICUs transfused at platelet count thresholds above 25×10$^{9}$/L in non-bleeding infants of GA of <28 weeks, while the 25×10$^{9}$/L threshold was associated with a lower risk of harm in a recent trial. FFP transfusions were administered for coagulopathy without active bleeding in 39% and for hypotension in 25% of NICUs. Transfusion volume, duration and rate varied by factors up to several folds between NICUs. CONCLUSIONS Transfusion thresholds and aspects of administration vary widely across European NICUs. In general, transfusion thresholds used tend to be more liberal compared with data from recent trials supporting the use of more restrictive thresholds. Further research is needed to identify the barriers and enablers to incorporation of recent trial findings into neonatal transfusion practice.
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- 2023
22. Components of Perinatal Palliative Care: An Integrative Review
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Dombrecht, Laure, primary, Chambaere, Kenneth, additional, Beernaert, Kim, additional, Roets, Ellen, additional, De Vilder De Keyser, Mona, additional, De Smet, Gaëlle, additional, Roelens, Kristien, additional, and Cools, Filip, additional
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- 2023
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23. Is neurally adjusted ventilatory assist feasible and safe in the extremely preterm infant?
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Lefevere, Julie, primary and Cools, Filip, additional
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- 2023
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24. Survey of transfusion practices in preterm infants in Europe
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Scrivens, Alexandra, primary, Reibel, Nora Johanna, additional, Heeger, Lisanne, additional, Stanworth, Simon, additional, Lopriore, Enrico, additional, New, Helen V, additional, Dame, Christof, additional, Fijnvandraat, Karin, additional, Deschmann, Emöke, additional, Aguar, Marta, additional, Brække, Kristin, additional, Cardona, Francesco Stefano, additional, Cools, Filip, additional, Farrugia, Ryan, additional, Ghirardello, Stefano, additional, Lozar, Jana, additional, Matasova, Katarina, additional, Muehlbacher, Tobias, additional, Sankilampi, Ulla, additional, Soares, Henrique, additional, Szabo, Miklos, additional, Szczapa, Tomasz, additional, Zaharie, Gabriela, additional, Roehr, Charles Christoph, additional, and Fustolo-Gunnink, Suzanne, additional
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- 2023
- Full Text
- View/download PDF
25. Effect of systemic hydrocortisone in ventilated preterm infants on parent-reported behavioural outcomes at 2 years’ corrected age: follow-up of a randomised clinical trial
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Halbmeijer, Nienke Marjolein, primary, Onland, Wes, additional, Cools, Filip, additional, Swarte, Renate M, additional, van der Heide-Jalving, Marja, additional, Dijk, Peter, additional, Mulder-de Tollenaer, Susanne, additional, Tan, Ratna N G B, additional, Mohns, Thilo, additional, Bruneel, Els, additional, van Heijst, Arno F J, additional, Kramer, Boris, additional, Debeer, Anne, additional, van Weissenbruch, Mirjam M, additional, Marechal, Yoann, additional, Blom, Henry, additional, Plaskie, Katleen, additional, Offringa, Martin, additional, van Wassenaer-Leemhuis, Aleid G, additional, van Kaam, Anton H, additional, and Aarnoudse-Moens, Cornelieke S H, additional
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- 2023
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26. Cerebral oxygenation and body position in the preterm infant: A systematic review and meta‐analysis
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Maes, Eva, primary, Cools, Filip, additional, Dereymaeker, Anneleen, additional, Jansen, Katrien, additional, Naulaers, Gunnar, additional, and Thewissen, Liesbeth, additional
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- 2022
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27. Efficacy and Safety of Enteral Recombinant Human Insulin in Preterm Infants
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FIT-04 Study Group, Mank, Elise, Sáenz de Pipaón, Miguel, Lapillonne, Alexandre, Carnielli, Virgilio P, Senterre, Thibault, Shamir, Raanan, van Toledo, Letty, van Goudoever, Johannes B, Cools, Filip, UZB Other, Clinical sciences, Growth and Development, Neonatology, Pediatric surgery, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Reproduction & Development (AR&D), Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and ARD - Amsterdam Reproduction and Development
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Male ,Milk, Human ,Infant, Newborn ,Infant ,Preterm infants ,Enteral Recombinant Human Insulin ,Enteral Nutrition ,Enterocolitis, Necrotizing ,Pediatrics, Perinatology and Child Health ,Birth Weight ,Humans ,Insulin ,Female ,clinical trail ,Pediatrics, Perinatology, and Child Health ,Infant, Premature - Abstract
Importance: Feeding intolerance is a common condition among preterm infants owing to immaturity of the gastrointestinal tract. Enteral insulin appears to promote intestinal maturation. The insulin concentration in human milk declines rapidly post partum and insulin is absent in formula; therefore, recombinant human (rh) insulin for enteral administration as a supplement to human milk and formula may reduce feeding intolerance in preterm infants. Objective: To assess the efficacy and safety of 2 different dosages of rh insulin as a supplement to both human milk and preterm formula. Design, Setting, and Participants: The FIT-04 multicenter, double-blind, placebo-controlled randomized clinical trial was conducted at 46 neonatal intensive care units throughout Europe, Israel, and the US. Preterm infants with a gestational age (GA) of 26 to 32 weeks and a birth weight of 500 g or more were enrolled between October 9, 2016, and April 25, 2018. Data were analyzed in January 2020. Interventions: Preterm infants were randomly assigned to receive low-dose rh insulin (400-μIU/mL milk), high-dose rh insulin (2000-μIU/mL milk), or placebo for 28 days. Main Outcomes and Measures: The primary outcome was time to achieve full enteral feeding (FEF) defined as an enteral intake of 150 mL/kg per day or more for 3 consecutive days. Results: The final intention-to-treat analysis included 303 preterm infants (low-dose group: median [IQR] GA, 29.1 [28.1-30.4] weeks; 65 boys [59%]; median [IQR] birth weight, 1200 [976-1425] g; high-dose group: median [IQR] GA, 29.0 [27.7-30.5] weeks; 52 boys [55%]; median [IQR] birth weight, 1250 [1020-1445] g; placebo group: median [IQR] GA, 28.8 [27.6-30.4] weeks; 54 boys [55%]; median [IQR] birth weight, 1208 [1021-1430] g). The data safety monitoring board advised to discontinue the study early based on interim futility analysis (including the first 225 randomized infants), as the conditional power did not reach the prespecified threshold of 35% for both rh-insulin dosages. The study continued while the data safety monitoring board analyzed and discussed the data. In the final intention-to-treat analysis, the median (IQR) time to achieve FEF was significantly reduced in 94 infants receiving low-dose rh insulin (10.0 [7.0-21.8] days; P = .03) and in 82 infants receiving high-dose rh insulin (10.0 [6.0-15.0] days; P = .001) compared with 85 infants receiving placebo (14.0 [8.0-28.0] days). Compared with placebo, the difference in median (95% CI) time to FEF was 4.0 (1.0-8.0) days for the low-dose group and 4.0 (1.0-7.0) days for the high-dose group. Weight gain rates did not differ significantly between groups. Necrotizing enterocolitis (Bell stage 2 or 3) occurred in 7 of 108 infants (6%) in the low-dose group, 4 of 88 infants (5%) in the high-dose group, and 10 of 97 infants (10%) in the placebo group. None of the infants developed serum insulin antibodies. Conclusions and Relevance: Results of this randomized clinical trial revealed that enteral administration of 2 different rh-insulin dosages was safe and compared with placebo, significantly reduced time to FEF in preterm infants with a GA of 26 to 32 weeks. These findings support the use of rh insulin as a supplement to human milk and preterm formula. Trial Registration: ClinicalTrials.gov Identifier: NCT02510560.
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- 2022
28. Proceedings of the 13th International Newborn Brain Conference: Neuroprotection strategies in the neonate
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Abou Mehrem, Ayman, Al Awad, Essa, Anninck, Kim, Au-Young, Stephanie, Aydinol, Nesil, Bartmann, Peter, Benders, Manon, Benlamri, Amina, Bolderheij, Leah, Celik, Yalcin, Chan, Natalie, Chau, Cecil, Chau, Vann, Chen, Xiaodi, Chetcuti Ganado, Claudia, Coetser, Annaleen, Cools, Filip, Da Rocha, Giselle, Deigner, Hans-Peter, Dereymaeker, Anneleen, Deshmukh, Laxmikant, Domonoske, Rose, Dossani, Salma, Dsouza, Jeanne M, El Gamal, Mayy, Eshemokhai, Peace, Esser, Michael, Fiedrich, Elsa, Franz, Axel, Ghosh, Anirban, Groenendaal, Floris, Grunau, Ruth E, Venkata, Sujith Kumar Reddy Gurram, Hamitoglu, Serif, Hellström-Westas, Lena, Irvine, Leigh, Jansen, Katrien, Javadyan, Artem, Jenkin, Graham, Kamanga, Noela, Kaur, Navneet, Keles, Elif, Keller, Matthias, Kelly, Edmond, Kesting, Samantha Jane, Kgwadi, Dikeledi, Kim, Boram, Kohl, Matthias, Kowal, Derek, Kricitober, Jennifer Damoi, Leijser, Lara, LePine, Mark, Lim, Yow-Pin, Lodha, Abhay, Londhe, Atul, Ly, Linh, Maes, Eva, Malhotra, Atul, Marlow, Neil, Mathew, Joseph L, McDonald, Courtney, McLean, Mia, Metcalfe, Cathy, Meyer, Ron, Miller, Steven P, Miller, Suzanne, Mogajane, Tshiamo, Mohammad, Khorshid, Momin, Sarfaraz, Montpetit, John, Mukiza, Nelson, Murthy, Prashanth, Scott, James N, Nakibuuka, Victoria, Nakwa, Firdose, Naulaers, Gunnar, Noort, Jennessa, Ntuli, Nandi, Ondongo-Ezhet, Claude, Paul, Renee, Pepper, Michael, Plum, Achim, Rombough, Bryan, Saugstad, Ola, Scotland, Jillian, Scott, James, Seake, Karabo, Sebunya, Robert, Selvanathan, Thiviya, Sepeng, Letlhogonolo, Simsek, Huseyin, Steins-Rang, Carola, Stonestreet, Barbara, Tang, Selphee, Taskin, Erdal, Thewissen, Liesbeth, Thomas, Sumesh, Thomas, Reenu, van Kwawegen, Alison, van Rensburg, Jeanne, Velaphi, Sithembiso, Wu, Yuqi, Yaman, Akan, Yapicioglu-Yildizdas, Hacer, Yawno, Tamara, Zaki, Pearl, Zein, Hussein, and Zhou, Lindsay
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Infant, Newborn ,Brain ,Humans ,Head ,Neuroprotection - Abstract
ispartof: J Neonatal Perinatal Med vol:15 issue:2 pages:427-439 ispartof: location:Netherlands status: published
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- 2022
29. Proceedings of the 13th International Newborn Brain Conference: Neuroprotection strategies in the neonate
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MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, Abou Mehrem, Ayman, Al Awad, Essa, Anninck, Kim, Au-Young, Stephanie, Aydinol, Nesil, Bartmann, Peter, Benders, Manon, Benlamri, Amina, Bolderheij, Leah, Celik, Yalcin, Chan, Natalie, Chau, Cecil, Chau, Vann, Chen, Xiaodi, Chetcuti Ganado, Claudia, Coetser, Annaleen, Cools, Filip, Da Rocha, Giselle, Deigner, Hans Peter, Dereymaeker, Anneleen, Deshmukh, Laxmikant, Domonoske, Rose, Dossani, Salma, Dsouza, Jeanne M., El Gamal, Mayy, Eshemokhai, Peace, Esser, Michael, Fiedrich, Elsa, Franz, Axel, Ghosh, Anirban, Groenendaal, Floris, Grunau, Ruth E., Venkata, Sujith Kumar Reddy Gurram, Hamitoglu, Serif, Hellström-Westas, Lena, Irvine, Leigh, Jansen, Katrien, Javadyan, Artem, Jenkin, Graham, Kamanga, Noela, Kaur, Navneet, Keles, Elif, Keller, Matthias, Kelly, Edmond, Kesting, Samantha Jane, Kgwadi, Dikeledi, Kim, Boram, Kohl, Matthias, Kowal, Derek, Kricitober, Jennifer Damoi, Leijser, Lara, LePine, Mark, Lim, Yow Pin, Lodha, Abhay, Londhe, Atul, Ly, Linh, Maes, Eva, Malhotra, Atul, Marlow, Neil, Mathew, Joseph L., McDonald, Courtney, McLean, Mia, Metcalfe, Cathy, Meyer, Ron, Miller, Steven P., Miller, Suzanne, Mogajane, Tshiamo, Mohammad, Khorshid, Momin, Sarfaraz, Montpetit, John, Mukiza, Nelson, Murthy, Prashanth, Scott, James N., Nakibuuka, Victoria, Nakwa, Firdose, Naulaers, Gunnar, Noort, Jennessa, Ntuli, Nandi, Ondongo-Ezhet, Claude, Paul, Renee, Pepper, Michael, Plum, Achim, Rombough, Bryan, Saugstad, Ola, Scotland, Jillian, Scott, James, Seake, Karabo, Sebunya, Robert, Selvanathan, Thiviya, Sepeng, Letlhogonolo, Simsek, Huseyin, Steins-Rang, Carola, Stonestreet, Barbara, Tang, Selphee, Taskin, Erdal, Thewissen, Liesbeth, Thomas, Sumesh, Thomas, Reenu, van Kwawegen, Alison, van Rensburg, Jeanne, Velaphi, Sithembiso, Wu, Yuqi, Yaman, Akan, Yapicioglu-Yildizdas, Hacer, Yawno, Tamara, Zaki, Pearl, Zein, Hussein, Zhou, Lindsay, MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, Abou Mehrem, Ayman, Al Awad, Essa, Anninck, Kim, Au-Young, Stephanie, Aydinol, Nesil, Bartmann, Peter, Benders, Manon, Benlamri, Amina, Bolderheij, Leah, Celik, Yalcin, Chan, Natalie, Chau, Cecil, Chau, Vann, Chen, Xiaodi, Chetcuti Ganado, Claudia, Coetser, Annaleen, Cools, Filip, Da Rocha, Giselle, Deigner, Hans Peter, Dereymaeker, Anneleen, Deshmukh, Laxmikant, Domonoske, Rose, Dossani, Salma, Dsouza, Jeanne M., El Gamal, Mayy, Eshemokhai, Peace, Esser, Michael, Fiedrich, Elsa, Franz, Axel, Ghosh, Anirban, Groenendaal, Floris, Grunau, Ruth E., Venkata, Sujith Kumar Reddy Gurram, Hamitoglu, Serif, Hellström-Westas, Lena, Irvine, Leigh, Jansen, Katrien, Javadyan, Artem, Jenkin, Graham, Kamanga, Noela, Kaur, Navneet, Keles, Elif, Keller, Matthias, Kelly, Edmond, Kesting, Samantha Jane, Kgwadi, Dikeledi, Kim, Boram, Kohl, Matthias, Kowal, Derek, Kricitober, Jennifer Damoi, Leijser, Lara, LePine, Mark, Lim, Yow Pin, Lodha, Abhay, Londhe, Atul, Ly, Linh, Maes, Eva, Malhotra, Atul, Marlow, Neil, Mathew, Joseph L., McDonald, Courtney, McLean, Mia, Metcalfe, Cathy, Meyer, Ron, Miller, Steven P., Miller, Suzanne, Mogajane, Tshiamo, Mohammad, Khorshid, Momin, Sarfaraz, Montpetit, John, Mukiza, Nelson, Murthy, Prashanth, Scott, James N., Nakibuuka, Victoria, Nakwa, Firdose, Naulaers, Gunnar, Noort, Jennessa, Ntuli, Nandi, Ondongo-Ezhet, Claude, Paul, Renee, Pepper, Michael, Plum, Achim, Rombough, Bryan, Saugstad, Ola, Scotland, Jillian, Scott, James, Seake, Karabo, Sebunya, Robert, Selvanathan, Thiviya, Sepeng, Letlhogonolo, Simsek, Huseyin, Steins-Rang, Carola, Stonestreet, Barbara, Tang, Selphee, Taskin, Erdal, Thewissen, Liesbeth, Thomas, Sumesh, Thomas, Reenu, van Kwawegen, Alison, van Rensburg, Jeanne, Velaphi, Sithembiso, Wu, Yuqi, Yaman, Akan, Yapicioglu-Yildizdas, Hacer, Yawno, Tamara, Zaki, Pearl, Zein, Hussein, and Zhou, Lindsay
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- 2022
30. Short-term pulmonary and systemic effects of hydrocortisone initiated 7–14 days after birth in ventilated very preterm infants: a secondary analysis of a randomised controlled trial
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Halbmeijer, Nienke M, primary, Onland, Wes, additional, Cools, Filip, additional, Kroon, Andre, additional, van der Heide-Jalving, Marja, additional, Dijk, Peter, additional, van Straaten, Henrica L M, additional, te Pas, Arjan B, additional, Mohns, Thilo, additional, Bruneel, Els, additional, van Heijst, Arno F J, additional, Kramer, Boris, additional, Debeer, Anne, additional, Zonnenberg, Inge A, additional, Marechal, Yoann, additional, Blom, Henry, additional, Plaskie, Katleen, additional, Merkus, Maruschka P, additional, Offringa, Martin, additional, and van Kaam, Anton H, additional
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- 2022
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31. End-of-life decisions in neonates and infants: a nationwide mortality follow-back survey
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Dombrecht, Laure, primary, Beernaert, Kim, additional, Chambaere, Kenneth, additional, Cools, Filip, additional, Goossens, Linde, additional, Naulaers, Gunnar, additional, Cornette, Luc, additional, Laroche, Sabrina, additional, Theyskens, Claire, additional, Vandeputte, Christine, additional, Van de Broek, Hilde, additional, Cohen, Joachim, additional, and Deliens, Luc, additional
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- 2022
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32. sj-pdf-1-pmj-10.1177_02692163221076365 ��� Supplemental material for Barriers and facilitators for parents in end-of-life decision-making for neonates at the Neonatal Intensive Care Unit: A qualitative study
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Piette, Veerle, Dombrecht, Laure, Deliens, Luc, Cools, Filip, Chambaere, Kenneth, Goossens, Linde, Naulaers, Gunnar, Laroche, Sabine, Cornette, Luc, Bekaert, Eline, Decoster, Pauline, Beernaert, Kim, and Cohen, Joachim
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FOS: Clinical medicine ,111702 Aged Health Care ,FOS: Health sciences ,110308 Geriatrics and Gerontology - Abstract
Supplemental material, sj-pdf-1-pmj-10.1177_02692163221076365 for Barriers and facilitators for parents in end-of-life decision-making for neonates at the Neonatal Intensive Care Unit: A qualitative study by Veerle Piette, Laure Dombrecht, Luc Deliens, Filip Cools, Kenneth Chambaere, Linde Goossens, Gunnar Naulaers, Sabine Laroche, Luc Cornette, Eline Bekaert, Pauline Decoster, Kim Beernaert and Joachim Cohen in Palliative Medicine
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- 2022
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33. sj-pdf-2-pmj-10.1177_02692163221076365 ��� Supplemental material for Barriers and facilitators for parents in end-of-life decision-making for neonates at the Neonatal Intensive Care Unit: A qualitative study
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Piette, Veerle, Dombrecht, Laure, Deliens, Luc, Cools, Filip, Chambaere, Kenneth, Goossens, Linde, Naulaers, Gunnar, Laroche, Sabine, Cornette, Luc, Bekaert, Eline, Decoster, Pauline, Beernaert, Kim, and Cohen, Joachim
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FOS: Clinical medicine ,111702 Aged Health Care ,FOS: Health sciences ,110308 Geriatrics and Gerontology - Abstract
Supplemental material, sj-pdf-2-pmj-10.1177_02692163221076365 for Barriers and facilitators for parents in end-of-life decision-making for neonates at the Neonatal Intensive Care Unit: A qualitative study by Veerle Piette, Laure Dombrecht, Luc Deliens, Filip Cools, Kenneth Chambaere, Linde Goossens, Gunnar Naulaers, Sabine Laroche, Luc Cornette, Eline Bekaert, Pauline Decoster, Kim Beernaert and Joachim Cohen in Palliative Medicine
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- 2022
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34. Additional file 1 of Consultation of parents and healthcare professionals in end-of-life decision-making for neonates and infants: a population-level mortality follow-back physician survey
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Dombrecht, Laure, Cools, Filip, Cohen, Joachim, Deliens, Luc, Goossens, Linde, Naulaers, Gunnar, Beernaert, Kim, and Chambaere, Kenneth
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Additional file 1.
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- 2022
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35. Cerebral oxygenation and body position in the preterm infant: A systematic review and meta‐analysis.
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Maes, Eva, Cools, Filip, Dereymaeker, Anneleen, Jansen, Katrien, Naulaers, Gunnar, and Thewissen, Liesbeth
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POSTURE , *PREMATURE infants , *PATIENT positioning , *SUPINE position , *CEREBRAL circulation - Abstract
Aim: After preterm birth, supine head midline position is supported for stable cerebral blood flow (CBF) and prevention of intraventricular haemorrhage (IVH), while prone position supports respiratory function and enables skin‐to‐skin care. The prone compared to supine position could lead to a change in near‐infrared derived cerebral tissue oxygen saturation (rScO2), which is a surrogate for cerebral blood flow (CBF). By monitoring rScO2 neonatologists aim to stabilise CBF during intensive care and prevent brain injury. In this systematic review and meta‐analysis, we investigate the effect of the body position on rScO2. Methods: A comprehensive literature search was performed to identify all trials that included preterm infants in the first 2 weeks after birth and compared rScO2 in the prone versus supine head in midline position of the infant. A meta‐analysis, including two subgroup analyses based on postnatal age (PNA) and gestational age (GA), was performed. Results: Six observational cohort studies were included. In the second, but not the first week after birth, a significant higher rScO2 in the prone position was found with a mean difference of 1.97% (95% CI 0.87–3.07). No rScO2 difference was observed between positions in the extremely preterm nor the preterm group. Conclusion: No consistent evidence was found that body position influences rScO2 in the first 2 weeks after preterm birth. Subgroup analysis suggests that in the second week after birth, the prone position might result in higher cerebral rScO2 than the supine position with head in midline. Multiple factors determine the best body position in preterms. [ABSTRACT FROM AUTHOR]
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- 2023
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36. Short-term pulmonary and systemic effects of hydrocortisone initiated 7-14 days after birth in ventilated very preterm infants: a secondary analysis of a randomised controlled trial.
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Halbmeijer, Nienke M., Onland, Wes, Cools, Filip, Kroon, Andre, van der Heide-Jalving, Marja, Dijk, Peter, van Straaten, Henrica L. M., te Pas, Arjan B., Mohns, Thilo, Bruneel, Els, van Heijst, Arno F. J., Kramer, Boris, Debeer, Anne, Zonnenberg, Inge A., Marechal, Yoann, Blom, Henry, Plaskie, Katleen, Merkus, Maruschka P., Offringa, Martin, and van Kaam, Anton H.
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PREMATURE infants ,MECONIUM aspiration syndrome ,RANDOMIZED controlled trials ,HYDROCORTISONE ,VERY low birth weight ,SECONDARY analysis - Published
- 2023
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37. Barriers and facilitators for parents in end-of-life decision-making for neonates at the Neonatal Intensive Care Unit: A qualitative study
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Piette, Veerle, primary, Dombrecht, Laure, additional, Deliens, Luc, additional, Cools, Filip, additional, Chambaere, Kenneth, additional, Goossens, Linde, additional, Naulaers, Gunnar, additional, Laroche, Sabine, additional, Cornette, Luc, additional, Bekaert, Eline, additional, Decoster, Pauline, additional, Beernaert, Kim, additional, and Cohen, Joachim, additional
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- 2022
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38. Short-term effects of systemic hydrocortisone initiated 7 to 14 days after birth in ventilated very preterm infants
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Halbmeijer, Nienke, Onland, Wes, Cools, Filip, Kroon, Andre, van der Heide-Jalving, Marja, Dijk, Peter, van Straaten, Henrica, te Pas, Arjan, Mohns, Thilo, Bruneel, Els, van Heijst, Arno, Kramer, Boris, Debeer, Anne, Zonnenberg, Inge, Marechal, Yoann, Blom, Henry, Plaskie, Katleen, Offringa, Martin, Van Kaam, Anton, Clinical sciences, Growth and Development, and Neonatology
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birth ,ventilated patients ,Pediatrics, Perinatology, and Child Health ,Very preterm birth - Published
- 2021
39. Survey of transfusion practices in European preterm infants (step survey)
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Scrivens, Alexandra, Reibel, Nora-Johanna, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico, New, Helen, Dame, Christof, Deschmann, Emoke, Fijnvandraat, Karin, van der Bom, Anske, Carrascosa, Marta Aguar, Braekke, Kristin, Cardona, Francesco, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Krivec, Jana Lozar, Matasova, Katarina, Muhlbacher, Tobias, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christof, Fustolo-Gunnink, Suzanne, Clinical sciences, Growth and Development, and Neonatology
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transfusion practices ,Pediatrics, Perinatology, and Child Health ,European preterm infants - Published
- 2021
40. Novel PIEZO2 mutation in a new born with congenital arthrogryposis multiplex
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Uyttebroeck, Sophie, Van de Voorde, Stefanie Rosa, Gheldof, Alexander, Smeets, Nathalie Maria G, Cools, Filip, Andrzejewski, Aurélie Carine, Keymolen, K., Hes, Frederik Jan, Dimitrov, Boyan, Medical Genetics, Faculty of Medicine and Pharmacy, Clinical sciences, Physiotherapy, Human Physiology and Anatomy, Pediatrics, UZB Other, Growth and Development, Neonatology, and Orthopaedics - Traumatology
- Abstract
Background: A female baby patient, first child of non-consanguineous couple of North-European origin was referred to the Genetics Clinic. During the second and third pregnancy trimester, foetal ultrasound assessment failed to detect any congenital abnormalities. The girl was born at 36 weeks of gestation by caesarean section with birth weight of 2230 grams and head circumference of 34.5 centimetres. She was hospitalized in the neonatal intensive care unit for respiratory support. Clinical assessment detected generalised arthrogryposis with severe bilateral clubfeet deformity, bilateral hip dislocation, clenched hands, ulnar finger deviation, clinodactyly, camptodactyly, and dysmorphic facial features such as brachycephaly, mild hypertelorism, central cleft palate, whistling face, low set, and posteriorly rotated ears. The initial treatment consisted of physiotherapy and casting. She was discharged from the neonatal intensive care unit after 20-days and follow-up was arranged in a specialized care facility. Methods: Gene panel testing for neuromuscular disorders was performed on Illumina NGS sequencing system and class 4 (likely pathogenic) or 5 (pathogenic) variants were reported and subsequently confirmed by Sanger sequencing. Results: A de novo heterozygous class 4 variant NM_022068.2(PIEZO2 ): c.8199_8202delAATA p.(Leu2733Phefs*10) in PIEZO2 gene was detected. Discussion: Congenital arthrogryposis is a broad spectrum of genetic and non-genetic conditions with overlapping clinical features. Heterozygous pathogenic variants in PIEZO2 are known to cause 3 types of arthrogryposis: Gordon syndrome (distal arthrogryposis type 3), Marden-Walker syndrome and Distal arthrogryposis type 5. These clinically and genetically overlapping syndromes are now considered to represent variable expression of the same disorder. Although there is no clear genotype- phenotype correlation, there are some differences among these syndromes. The clinical features of the presented patient tend most to correlate with Gordon syndrome phenotype, which is typically characterized by clenching of hands and feet, camptodactyly, clubfoot, and less frequently, cleft palate. The detected PIEZO2 variant is a frame shift variant, resulting in a premature stop codon. It is located 20 amino acids before the normal stop codon and has not been previously reported. This PIEZO2 gene variant was presumed to be likely pathogenic given that there is another reported patient with proven pathogenic PIEZO2 gene variant that is located downstream of this PIEZO2 position. Conclusion: A patient with phenotype of Gordon syndrome is presented, one of the three disorders known to be caused by PIEZO2 pathogenic variants.
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- 2021
41. Non-invasive neurally adjusted ventilatory assist in preterm infants with RDS: effect of changing NAVA levels
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Lefevere, Julie, primary, Van Delft, Brenda, additional, Vervoort, Michel, additional, Cools, Wilfried, additional, and Cools, Filip, additional
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- 2021
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42. Multi-centre, randomised non-inferiority trial of early treatment versus expectant management of patent ductus arteriosus in preterm infants (the BeNeDuctus trial): statistical analysis plan.
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Hundscheid, Tim, Donders, Rogier, Onland, Wes, Kooi, Elisabeth M. W., Vijlbrief, Daniel C., de Vries, Willem B., Nuytemans, Debbie H. G. M., van Overmeire, Bart, Mulder, Antonius L., de Boode, Willem P., on behalf of the BeNeDuctus trial study group, Dijk, Peter H., van Kaam, Anton H. L. C., de Baat, Tessa, Dijkman, Koen P., Villamor, Eduardo, Kroon, André A., Visser, Remco, de Tollenaer, Susanne M., and Cools, Filip
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PREMATURE infants ,PATENT ductus arteriosus ,STATISTICS ,BRONCHOPULMONARY dysplasia ,DRUG therapy ,GESTATIONAL age ,EVALUATION of medical care ,RESEARCH ,IBUPROFEN ,RESEARCH methodology ,MEDICAL cooperation ,EVALUATION research ,LOW birth weight ,COMPARATIVE studies ,RANDOMIZED controlled trials ,RESEARCH funding - Abstract
Background: Controversy exists about the optimal management of a patent ductus arteriosus (PDA) in preterm infants. A persistent PDA is associated with neonatal mortality and morbidity, but causality remains unproven. Although both pharmacological and/or surgical treatment are effective in PDA closure, this has not resulted in an improved neonatal outcome. In most preterm infants, a PDA will eventually close spontaneously, hence PDA treatment potentially increases the risk of iatrogenic adverse effects. Therefore, expectant management is gaining interest, even in the absence of convincing evidence to support this strategy.Methods/design: The BeNeDuctus trial is a multicentre, randomised, non-inferiority trial assessing early pharmacological treatment (24-72 h postnatal age) with ibuprofen versus expectant management of PDA in preterm infants in Europe. Preterm infants with a gestational age of less than 28 weeks and an echocardiographic-confirmed PDA with a transductal diameter of > 1.5 mm are randomly allocated to early pharmacological treatment with ibuprofen or expectant management after parental informed consent. The primary outcome measure is the composite outcome of mortality, and/or necrotizing enterocolitis Bell stage ≥ IIa, and/or bronchopulmonary dysplasia, all established at a postmenstrual age of 36 weeks. Secondary short-term outcomes are comorbidity and adverse events assessed during hospitalization and long-term neurodevelopmental outcome assessed at a corrected age of 2 years. This statistical analysis plan focusses on the short-term outcome and is written and submitted without knowledge of the data.Trial Registration: ClinicalTrials.gov NTR5479. Registered on October 19, 2015, with the Dutch Trial Registry, sponsored by the United States National Library of Medicine Clinicaltrials.gov NCT02884219 (registered May 2016) and the European Clinical Trials Database EudraCT 2017-001376-28. [ABSTRACT FROM AUTHOR]- Published
- 2021
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43. Continuous Deep Sedation until Death in Neonates and Infants in Flanders: A Post-Mortem Survey.
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Dombrecht, Laure, Cools, Filip, Cohen, Joachim, Deliens, Luc, Goossens, Linde, Naulaers, Gunnar, Chambaere, Kenneth, and Beernaert, Kim
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NEWBORN infants , *INFANTS , *ADULTS , *AGE groups , *DRUG utilization , *DEATH certificates , *NEONATAL mortality , *PERSISTENT vegetative state , *BACK injuries - Abstract
Background: The use of analgesics and sedatives to alleviate pain and discomfort is common in end-of-life care in neonates and infants. However, to what extent those drugs are used in that context with the specific aim of bringing the infant in a state of continuous deep sedation (CDS) is currently unknown. Methods: We performed a nationwide mortality follow-back survey based on all deaths under the age of 1 over a period of 16 months in Flanders, Belgium. Data on CDS were linked to sociodemographic information from death certificates. Physicians completed an anonymous questionnaire. Questions measured whether CDS preceded death, and which clinical characteristics were associated with the sedation (e.g., type of drugs used and the duration of sedation). Results: The response rate was 83% (229/276). In 39% of all deceased neonates and infants, death was preceded by CDS. Physicians used a combination of morphine and benzodiazepines in 53%, or morphine alone in 45% of all sedation cases in order to continuously and deeply sedate the infant. In 89% of cases, death occurred within 1 week after sedation was begun, and in 92% of cases, artificial nutrition and hydration were administered until death. In 49% of cases there was no intention to hasten death, and in 40% of cases, the possibility of hastening was taken into account. Conclusions: CDS precedes about 2 in 5 neonatal and infant deaths. Guidelines for CDS in this age group are non-existent and it is unclear whether the same recommendations as in the adult population apply and can be considered a good practice. [ABSTRACT FROM AUTHOR]
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- 2021
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44. End-of-life decisions in neonates and infants: a population-level mortality follow-back study.
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Dombrecht, Laure, Beernaert, Kim, Chambaere, Kenneth, Cools, Filip, Goossens, Linde, Naulaers, Gunnar, Cohen, Joachim, Deliens, Luc, and NICU consortium
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TERMINAL care ,DECISION making ,NEONATOLOGY ,DEATH ,PASSIVE euthanasia ,PALLIATIVE treatment - Published
- 2022
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45. Supplemental Iron and Recombinant Erythropoietin for Anemia in Infants Born Very Preterm: A Survey of Clinical Practice in Europe.
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Reibel-Georgi NJ, Scrivens A, Heeger LE, Lopriore E, New HV, Deschmann E, Stanworth SJ, Carrascosa MA, Brække K, Cardona F, Cools F, Farrugia R, Ghirardello S, Krivec JL, Matasova K, Muehlbacher T, Sankilampi U, Soares H, Szabó M, Szczapa T, Zaharie G, Roehr CC, Fustolo-Gunnink S, and Dame C
- Abstract
Objectives: To survey practices of iron and recombinant human erythropoietin (rhEpo) administration to infants born preterm across Europe., Study Design: Over a three-month period, we conducted an online survey in 597 neonatal intensive care units (NICUs) of 18 European countries treating infants born with a gestational age (GA) <32 weeks., Results: 343 NICUs (response rate 56·3%) completed the survey. Almost all (97·7%) NICUs routinely supplement enteral iron, and 74·3% of respondents to all infants born <32 weeks' GA. 65·3% of NICUs routinely evaluate erythropoiesis and iron parameters beyond day 28 after birth. Most NICUs initiate iron supplementation at postnatal age of two weeks and stop after 6 (34·3%) or 12 months (34·3%). Routine use of rhEpo was reported in 22·2% of NICUs, and in individual cases in 6·9%. RhEpo was mostly administered subcutaneously (70·1%) and most frequently at a dose of 250 U/kg 3 times a week (44·3%), but the dose varied greatly between centers., Conclusion: This survey highlights wide heterogeneity in evaluating erythropoietic activity and iron deficiency in infants born preterm. Variation in iron supplementation during infancy likely reflects an inadequate evidence base. Current evidence on the efficacy and safety profile of rhEpo is only poorly translated into clinical practice. This survey demonstrates a need for standards to optimize patient blood management in anemia of prematurity., (Copyright © 2024. Published by Elsevier Inc.)
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- 2024
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46. Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates: 2-Year Follow-Up of a Randomized Clinical Trial.
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Gallini F, De Rose DU, Iuliano R, Romeo DM, Tana M, Paladini A, Fusco FP, Nobile S, Cota F, Tirone C, Aurilia C, Lio A, Esposito A, Costa S, D'Andrea V, Ventura ML, Carnielli V, Dani C, Mosca F, Fumagalli M, Scarpelli G, Giordano L, Fasolato V, Petrillo F, Betta P, Solinas A, Gitto E, Gargano G, Mescoli G, Martinelli S, Di Fabio S, Bernardo I, Tina LG, Staffler A, Stasi I, Mondello I, Scapillati E, Vedovato S, Maffei G, Bove A, Vitaliti M, Terrin G, Lago P, Gizzi C, Strozzi C, Villani PE, Berardi A, Cacace C, Bracaglia G, Pascucci E, Cools F, Pillow JJ, Polglase G, Pastorino R, van Kaam AH, Mercuri E, Orfeo L, Vento G, Malguzzi S, Rigotti C, Cecchi A, Nigro G, Costabile CD, Roma E, Sindico P, Venafra R, Mattia C, Conversano M, Ballardini E, Manganaro A, Balestri E, Gallo C, Catenazzi P, Astori MG, Maranella E, Grassia C, Maiolo K, Castellano D, Massenzi L, Chiodin E, Gallina MR, Consigli C, Sorrentino E, Bonato S, Mancini M, Perniola R, Giannuzzo S, Tranchina E, Cardilli V, Dito L, Regoli D, Tormena F, Battajon N, Arena R, Allais B, Guidotti I, Roversi F, Meli V, Tulino V, and Casati A
- Subjects
- Humans, Male, Female, Infant, Newborn, Follow-Up Studies, High-Frequency Ventilation methods, Child, Preschool, Intensive Care Units, Neonatal statistics & numerical data, Treatment Outcome, Italy, Infant, Pulmonary Surfactants administration & dosage, Pulmonary Surfactants therapeutic use, Infant, Extremely Premature, Respiratory Distress Syndrome, Newborn therapy, Respiratory Distress Syndrome, Newborn drug therapy
- Abstract
Importance: A multicenter randomized clinical trial (RCT) showed a lung recruitment maneuver using high-frequency oscillatory ventilation just before surfactant administration (ie, intubate-recruit-surfactant-extubate [IN-REC-SUR-E]) improved the efficacy of treatment compared with the standard intubate-surfactant-extubate (IN-SUR-E) technique without increasing the risk of adverse neonatal outcomes., Objective: To examine follow-up outcomes at corrected postnatal age (cPNA) 2 years of preterm infants previously enrolled in an RCT and treated with IN-REC-SUR-E or IN-SUR-E in 35 tertiary neonatal intensive care units., Design, Setting, and Participants: This was a follow-up study of infants recruited into the primary RCT from 2015 to 2018 at 35 tertiary neonatal intensive care units (NICUs) in Italy. Follow-up examinations included neurodevelopmental, growth, and respiratory outcomes of these children at cPNA 2 years. Participants included spontaneously breathing extremely preterm neonates (24 0/7 to 27 6/7 weeks' gestation) reaching failure criteria for continuous positive airway pressure within the first 24 hours of life. Data were analyzed from April 2023 to January 2024., Intervention: Infants were randomly assigned (1:1) to IN-REC-SUR-E or IN-SUR-E and then followed up., Main Outcomes and Measures: The primary outcome was the occurrence of death after discharge or major disability at cPNA 2 years. Secondary outcomes were neurodevelopmental outcomes (major disability, cerebral palsy, cognitive impairment, visual deficit, or auditory deficit), anthropometric measurements (weight, length, and head circumference), and recurrent respiratory infections and hospitalizations because of respiratory causes at 2y cPNA., Results: A total of 137 extremely preterm infants (median [IQR] gestational age, 26.5 [25.3-27.5] weeks and 75 [54.7%] female), initially enrolled in the original RCT, were followed up at cPNA 2 years, including 64 infants in the IN-SUR-E group and 73 infants in the IN-REC-SUR-E group. There were no significant differences in the occurrence of death after discharge or major disability at cPNA 2 years (IN-SUR-E: 13 children [20.3%] vs IN-REC-SUR-E: 10 children [13.7%]; P = .36). There were no significant differences in incidence of disability, cerebral palsy, or cognitive impairment in the IN-REC-SUR-E group compared with the IN-SUR-E group. There were no significant differences in anthropometric measurements (weight, length, and head circumference) between groups. There were no significant differences in the incidence of recurrent respiratory infections or in hospitalizations because of respiratory causes between groups., Conclusions and Relevance: In this RCT of lung recruitment before surfactant vs standard care there were no significant differences between the 2 groups in death, neurodevelopmental outcomes, anthropometric measurements, or recurrent respiratory infections at the 2-year follow-up. These findings can aid clinicians in decision-making for the best strategy to administer surfactant, considering long-term outcomes.
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- 2024
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47. A Retrospective Study Evaluating Guideline Adherence of Neonatal Parenteral Nutrition in a Belgian Neonatal Intensive Care Unit.
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Nguyen TD, Meers G, Cortoos PJ, Steurbaut S, and Cools F
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Introduction Clinical nutrition for preterm and critically ill neonates remains a challenge. Preterms are often hemodynamically and metabolically compromised, which limits infusion volumes of nutrients and hinders achieving recommended nutrient intakes. While guidelines provide recommended ranges for parenteral nutrition (PN) intakes, they generally recommend enteral nutrition as soon as possible. Thus, in clinical practice, gradually increasing EN intakes complicates assessments of PN guideline adherence. Via a pragmatic approach, we assessed adherence to PN recommendations for macronutrients and energy as stated in the 2018 guidelines of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). Methods In this retrospective study, we assessed the nutrition of preterm and critically ill term neonates from the neonatal intensive care unit of the University Hospital Brussels. We analyzed intakes for the first week of life, in which critically ill neonates at our center usually receive the majority of nutrients via PN. The PN-based provision of macronutrients and energy was analyzed descriptively in relation to the ESPGHAN 2018 recommendations. Results Macronutrients and energy provision gradually increased until they reached recommended or targeted values. Compared to term neonates, energy and lipid provision for preterms increased faster, while amino acid provision exceeded the ESPGHAN 2018 recommendations. Conclusions This study adds clinical practice data to the severely understudied field of the ESPGHAN 2018 PN guideline compliance. Using a pragmatic assessment of our nutrition protocols, we found the need to reduce the amount of amino acids per kg body weight per day to meet guideline recommendations., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Nguyen et al.)
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- 2024
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