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Secretory carcinoma (SC) is a rare recently described entity that has characteristics similar to those of secretory breast carcinoma. We report a case of a 23 years old male with a swelling on the parotid gland. The ultrasonography guided fine needle aspiration cytology was performed on mass. Cytologically, the background of the aspirate is composed of inflammatory cells admixed with mucinous material. There were isolated cells as much as loosely cohesive clusters making papillary follicle-like glands with eosinophilic material in the lumen. Tumor cells were medium-sized round shape and eccentric nuclei with prominent nucleoli, remarkably vacuolated cytoplasm. The parotidectomy was per- formed and the pathology report revealed a SC. Histologically, the tumor is composed of microcystic, follicular, and micropapillary areas. The cytoplasm is usually vacuolated with also clear eosinophilic appearance. Immunohistochemically, tumor cells labeled with S100, MUC-4. At 5 years, the patient is disease-free and under regular follow-up.

Objective: Studies have been performed on many biomolecules to determine the prognosis of LSCC and predict the course of the disease. However, a molecular marker that can be used clinically has not yet been found. Therefore, in this study, we aimed to investigate the expression levels of LRIG 1 in laryngeal cancer.Materials and Methods: In our study, 219 cases who underwent surgery due to LSCC and 88 randomly selected patients whose pathologic result were benign and premalignant lesions in Marmara University Pendik Education and Research Hospital between 2003 and 2018 were analyzed. Patients’ data were obtained from the medical records. The tissue microarray method was used to evaluate specimens.Results: There was a statistically significant difference between the tumor differentiation, diagnosis, and the expression of LRIG1 (respectively p=0.045, p