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1. Digitalized transcranial electrical stimulation: A consensus statement

Author

Brunoni, Andre R, Ekhtiari, Hamed, Antal, Andrea, Auvichayapat, Paradee, Baeken, Chris, Benseñor, Isabela M., Bikson, Marom, Boggio, Paulo, Borroni, Barbara, Brighina, Filippo, Brunelin, Jerome, Carvalho, Sandra, Caumo, Wolnei, Ciechanski, Patrick, Charvet, Leigh, Clark, Vincent P., Cohen Kadosh, Roi, Cotelli, Maria, Datta, Abhishek, Deng, Zhi-De, De Raedt, Rudi, De Ridder, Dirk, Fitzgerald, Paul B., Floel, Agnes, Frohlich, Flavio, George, Mark S., Ghobadi-Azbari, Peyman, Goerigk, Stephan, Hamilton, Roy H., Jaberzadeh, Shapour J., Hoy, Kate, Kidgell, Dawson J., Zonoozi, Arash Khojasteh, Kirton, Adam, Laureys, Steven, Lavidor, Michal, Lee, Kiwon, Leite, Jorge, Lisanby, Sarah H., Loo, Colleen, Martin, Donel M., Miniussi, Carlo, Mondino, Marine, Monte-Silva, Katia, Morales-Quezada, Leon, Nitsche, Michael A., Okano, Alexandre H., Oliveira, Claudia S., Onarheim, Balder, Pacheco-Barrios, Kevin, Padberg, Frank, Nakamura-Palacios, Ester M., Palm, Ulrich, Paulus, Walter, Plewnia, Christian, Priori, Alberto, Rajji, Tarek K., Razza, Lais B., Rehn, Erik M., Ruffini, Giulio, Schellhorn, Klaus, Zare-Bidoky, Mehran, Simis, Marcel, Skorupinski, Pawel, Suen, Paulo, Thibaut, Aurore, Valiengo, Leandro C.L., Vanderhasselt, Marie-Anne, Vanneste, Sven, Venkatasubramanian, Ganesan, Violante, Ines R., Wexler, Anna, Woods, Adam J., and Fregni, Felipe

Published
2022
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3. Digitizing Non-Invasive Neuromodulation Trials: Scoping Review, Process Mapping, and Recommendations from a Delphi Panel

Author

Brunoni, Andre R, primary, Ekhtiari, Hamed, additional, Antal, Andrea, additional, Auvichayapat, Paradee, additional, Baeken, Chris, additional, Benseñor, Isabela M., additional, Bikson, Marom, additional, Boggio, Paulo, additional, Borroni, Barbara, additional, Brighina, Filippo, additional, Brunelin, Jerome, additional, Carvalho, Sandra, additional, Caumo, Wolnei, additional, Ciechanski, Patrick, additional, Charvet, Leigh, additional, Clark, Vincent P., additional, Kadosh, Roi Cohen, additional, Cotelli, Maria, additional, Datta, Abhishek, additional, Deng, Zhi-De, additional, De Raedt, Rudi, additional, De Ridder, Dirk, additional, Fitzgerald, Paul B., additional, Floel, Agnes, additional, Frohlich, Flavio, additional, George, Mark S., additional, Ghobadi-Azbari, Peyman, additional, Goerigk, Stephan, additional, Hamilton, Roy H., additional, Jaberzadeh, Shapour J., additional, Hoy, Kate, additional, Kidgell, Dawson J., additional, Zonoozi, Arash Khojasteh, additional, Kirton, Adam, additional, Laureys, Steven, additional, Lavidor, Michal, additional, Lee, Kiwon, additional, Leite, Jorge, additional, Lisanby, Sarah H., additional, Loo, Colleen, additional, Martin, Donel M., additional, Miniussi, Carlo, additional, Mondino, Marine, additional, Monte-Silva, Katia, additional, Morales-Quezada, Leon, additional, Nitsche, Michael A., additional, Okano, Alexandre H., additional, Oliveira, Claudia S., additional, Onarheim, Balder, additional, Pacheco-Barrios, Kevin, additional, Padberg, Frank, additional, Nakamura-Palacios, Ester M, additional, Palm, Ulrich, additional, Paulus, Walter, additional, Plewnia, Christian, additional, Priori, Alberto, additional, Rajji, Tarek K., additional, Razza, Lais B., additional, Rehn, Erik M., additional, Ruffini, Giulio, additional, Schellhorn, Klaus, additional, Zare-Bidoky, Mehran, additional, Simis, Marcel, additional, Skorupinski, Pawel, additional, Suen, Paulo, additional, Thibaut, Aurore, additional, Valiengo, Leandro C. L., additional, Vanderhasselt, Marie-Anne, additional, Vanneste, Sven, additional, Venkatasubramanian, Ganesan, additional, Violante, Ines R., additional, Wexler, Anna, additional, Woods, Adam J., additional, and Fregni, Felipe, additional

Published
2022
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4. Digitizing Non-Invasive Neuromodulation Trials: Scoping Review, Process Mapping, and Recommendations from a Delphi Panel

Author

Brunoni, André Russowsky, primary, Ekhtiari, Hamed, additional, Antal, Andrea, additional, Auvichayapat, Paradee, additional, Baeken, Chris, additional, Benseñor, Isabela M., additional, Bikson, Marom, additional, Boggio, Paulo, additional, Borroni, Barbara, additional, Brighina, Filippo, additional, Brunelin, Jerome, additional, Carvalho, Sandra, additional, Caumo, Wolnei, additional, Ciechanski, Patrick, additional, Charvet, Leigh, additional, Clark, Vincent P., additional, Cohen Kadosh, Roi, additional, Cotelli, Maria, additional, Datta, Abhishek, additional, Deng, Zhi-De, additional, De Raedt, Rudi, additional, De Ridder, Dirk, additional, Fitzgerald, Paul B., additional, Floel, Agnes, additional, Frohlich, Flavio, additional, George, Mark S., additional, Ghobadi-Azbari, Peyman, additional, Goerigk, Stephan, additional, Hamilton, Roy H., additional, Jaberzadeh, Shapour, additional, Hoy, Kate, additional, Kidgell, Dawson, additional, Khojasteh Zonoozi, Arash, additional, Kirton, Adam, additional, Laureys, Steven, additional, Lavidor, Michal, additional, Lee, Kiwon, additional, Leite, Jorge, additional, Lisanby, Sarah H., additional, Loo, Colleen, additional, Martin, Donel M., additional, Miniussi, Carlo, additional, Mondino, Marine, additional, Monte-Silva, Kátia, additional, Morales-Quezada, Leon, additional, Nitsche, Michael, additional, Hideki Okano, Alexandre, additional, S. Oliveira, Claudia, additional, Onarheim, Balder, additional, Pacheco-Barrios, Kevin, additional, Padberg, Frank, additional, Nakamura-Palacios, Ester M., additional, Palm, Ulrich, additional, Paulus, Walter, additional, Plewnia, Christian, additional, Priori, Alberto, additional, Rajji, Tarek K., additional, Razza, Lais B., additional, Rehn, Erik M., additional, Ruffini, Giulio, additional, Schellhorn, Klaus, additional, Zare-Bidoky, Mehran, additional, Simis, Marcel, additional, Skorupinski, Pawel, additional, Suen, Paulo, additional, Thibaut, Aurore, additional, Valiengo, Leandro C. L., additional, Vanderhasselt, Marie-Anne, additional, Vanneste, Sven, additional, Venkatasubramanian, Ganesan, additional, Violante, Ines R., additional, Wexler, Anna, additional, Woods, Adam J., additional, and Fregni, Felipe, additional

Published
2022
Full Text
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5. Digitalized transcranial electrical stimulation: A consensus statement

Author

Andre R Brunoni, Hamed Ekhtiari, Andrea Antal, Paradee Auvichayapat, Chris Baeken, Isabela M. Benseñor, Marom Bikson, Paulo Boggio, Barbara Borroni, Filippo Brighina, Jerome Brunelin, Sandra Carvalho, Wolnei Caumo, Patrick Ciechanski, Leigh Charvet, Vincent P. Clark, Roi Cohen Kadosh, Maria Cotelli, Abhishek Datta, Zhi-De Deng, Rudi De Raedt, Dirk De Ridder, Paul B. Fitzgerald, Agnes Floel, Flavio Frohlich, Mark S. George, Peyman Ghobadi-Azbari, Stephan Goerigk, Roy H. Hamilton, Shapour J. Jaberzadeh, Kate Hoy, Dawson J. Kidgell, Arash Khojasteh Zonoozi, Adam Kirton, Steven Laureys, Michal Lavidor, Kiwon Lee, Jorge Leite, Sarah H. Lisanby, Colleen Loo, Donel M. Martin, Carlo Miniussi, Marine Mondino, Katia Monte-Silva, Leon Morales-Quezada, Michael A. Nitsche, Alexandre H. Okano, Claudia S. Oliveira, Balder Onarheim, Kevin Pacheco-Barrios, Frank Padberg, Ester M. Nakamura-Palacios, Ulrich Palm, Walter Paulus, Christian Plewnia, Alberto Priori, Tarek K. Rajji, Lais B. Razza, Erik M. Rehn, Giulio Ruffini, Klaus Schellhorn, Mehran Zare-Bidoky, Marcel Simis, Pawel Skorupinski, Paulo Suen, Aurore Thibaut, Leandro C.L. Valiengo, Marie-Anne Vanderhasselt, Sven Vanneste, Ganesan Venkatasubramanian, Ines R. Violante, Anna Wexler, Adam J. Woods, Felipe Fregni, Brain, Body and Cognition, Clinical sciences, Neuroprotection & Neuromodulation, Psychiatry, Brunoni, Andre R, Ekhtiari, Hamed, Antal, Andrea, Auvichayapat, Paradee, Baeken, Chri, Benseñor, Isabela M, Bikson, Marom, Boggio, Paulo, Borroni, Barbara, Brighina, Filippo, Brunelin, Jerome, Carvalho, Sandra, Caumo, Wolnei, Ciechanski, Patrick, Charvet, Leigh, Clark, Vincent P, Cohen Kadosh, Roi, Cotelli, Maria, Datta, Abhishek, Deng, Zhi-De, De Raedt, Rudi, De Ridder, Dirk, Fitzgerald, Paul B, Floel, Agne, Frohlich, Flavio, George, Mark S, Ghobadi-Azbari, Peyman, Goerigk, Stephan, Hamilton, Roy H, Jaberzadeh, Shapour J, Hoy, Kate, Kidgell, Dawson J, Zonoozi, Arash Khojasteh, Kirton, Adam, Laureys, Steven, Lavidor, Michal, Lee, Kiwon, Leite, Jorge, Lisanby, Sarah H, Loo, Colleen, Martin, Donel M, Miniussi, Carlo, Mondino, Marine, Monte-Silva, Katia, Morales-Quezada, Leon, Nitsche, Michael A, Okano, Alexandre H, Oliveira, Claudia S, Onarheim, Balder, Pacheco-Barrios, Kevin, Padberg, Frank, Nakamura-Palacios, Ester M, Palm, Ulrich, Paulus, Walter, Plewnia, Christian, Priori, Alberto, Rajji, Tarek K, Razza, Lais B, Rehn, Erik M, Ruffini, Giulio, Schellhorn, Klau, Zare-Bidoky, Mehran, Simis, Marcel, Skorupinski, Pawel, Suen, Paulo, Thibaut, Aurore, Valiengo, Leandro C L, Vanderhasselt, Marie-Anne, Vanneste, Sven, Venkatasubramanian, Ganesan, Violante, Ines R, Wexler, Anna, Woods, Adam J, and Fregni, Felipe

Subjects
Mobile Health, Consensus, Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, Clinical psychology, methods [Transcranial Direct Current Stimulation], Transcranial Direct Current Stimulation, Sensory Systems, Electric Stimulation, Telemedicine, Psychiatry and Mental health, Neurology, Physiology (medical), Delphi panel, Systematic review, Humans, Non-invasive neuromodulation, Neurology (clinical), ddc:610, Digital health
Abstract

Objective: Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, combined with mobile-Health technologies, could be incorporated in digital trials to overcome methodological barriers and increase equity of access. The study aims are to discuss the implementation of tES digital trials by performing a systematic scoping review and strategic process mapping, evaluate methodological aspects of tES digital trial designs, and provide Delphi-based recommendations for implementing digital trials using tES.Methods: We convened 61 highly-productive specialists and contacted 8 tES companies to assess 71 issues related to tES digitalization readiness, and processes, barriers, advantages, and opportunities for implementing tES digital trials. Delphi-based recommendations (>60% agreement) were provided.Results: The main strengths/opportunities of tES were: (i) non-pharmacological nature (92% of agreement), safety of these techniques (80%), affordability (88%), and potential scalability (78%). As for weaknesses/threats, we listed insufficient supervision (76%) and unclear regulatory status (69%). Many issues related to methodological biases did not reach consensus. Device appraisal showed moderate digitalization readiness, with high safety and potential for trial implementation, but low connectivity.Conclusions: Panelists recognized the potential of tES for scalability, generalizability, and leverage of digital trials processes; with no consensus about aspects regarding methodological biases. Significance: We further propose and discuss a conceptual framework for exploiting shared aspects between mobile-Health tES technologies with digital trials methodology to drive future efforts for digitizing tES trials. (C) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Published
2022

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