13 results on '"Chunguang Zhou"'
Search Results
2. The Effect of Halo‐Pelvic Traction on Bone Mineral Density of Vertebrae and Corresponding Risk Factors
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Xianming Huang, Peng Xiu, Yi Shu, Yueming Song, Zhongjie Zhou, Chunguang Zhou, Ganjun Feng, Lei Wang, Limin Liu, Jing Tang, and Xi Yang
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Bone Mineral Density ,Halo‐Pelvic Traction ,Qualitative Computed Tomography ,Severe Spinal Deformity ,Orthopedic surgery ,RD701-811 - Abstract
Objectives Decreased bone mineral density (BMD) is associated with complications in implantation surgery for severe spinal deformity. In this quantitative study, we aimed to investigate the impact of halo‐pelvic traction on vertebral bone mineral density (BMD) and identify the risk factors for a decrease in BMD. Methods Patients who underwent halo‐pelvic traction at our hospital between 2019 and 2022 were included in the study. Patients’ data, including height, weight, and BMD pre‐ and post‐traction, were collected and analyzed. Quantitative computed tomography (QCT) was used to determine the BMD. The paired rank sum test was used to evaluate the changes in each measurement parameter. Linear regression was used to identify risk factors for a decrease in BMD. Results Fifteen patients were included in the study, nine women and six men, with an average age of 21.2 ± 7.3 years. Eleven patients had severe rigid scoliosis, while four had tuberculotic kyphosis. One expert measured the BMD values of 345 vertebrae using QCT. The average traction time was 143.3 ± 44.4 days. The average pre‐traction BMD was 183.1 ± 73.8 mg/cm3, and the average post‐traction BMD was 140.5 ± 61.3 mg/cm3 (p
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- 2023
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3. Lumbar Disc Herniation with Contralateral Symptoms: A Case‐Series of 11 Patients and Literature Review
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Qingyang Gao, Huiliang Yang, Umar Masood, Chunguang Zhou, Ying Cen, and Yueming Song
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Diskectomy ,Intervertebral Disc Degeneration ,Laminectomy ,Sciatica ,Orthopedic surgery ,RD701-811 - Abstract
Objective Lumbar disc herniation (LDH) is a common pathology that typically causes unilateral radiculopathy on the same side as herniation, while patients may occasionally present with contralateral symptoms. Owing to the rare incidence of LDH with contralateral symptoms, the pathological mechanism remains unclear and the optimal surgical strategy is a subject of debate. This study aimed to provide new insights into the pathological mechanism of contralateral symptoms and assess the efficacy of ipsilateral hemilaminectomy and discectomy surgery in this population. Methods This study was a retrospective, single‐center, clinical case series, including 11 LDH cases with exclusive contralateral symptoms. We searched for LDH cases that were presented at our institution between January 2011 and December 2020. Adult LDH Patients with contralateral radicular pains were included, while those with ipsilateral radiculopathy, lumbar stenosis, foraminal stenosis on the symptomatic side, multilevel disc herniations, scoliosis, and lumbar operation history were excluded. Visual Analog Scale (VAS), clinical features, radiographic images, and other data were collected from the study cohort of 11 cases for further analysis. We also reviewed LDH cases in English literature from 1978 to 2023 to analyze their clinical characteristics and treatment. Results The incidence rate of LDH with contralateral symptoms in single‐level LDH cases was 0.32%. The average age of our 11 cases was 49.3 years old, and five of them were female (45.5%). All individuals had single‐level lateral LDH, with six cases (54.5%) located at L4‐5 and five cases (45.5%) located at L5‐S1. Upon admission, patients presented with lower back pain (seven cases, 63.6%), radicular pain (seven cases, 63.6%), hypoesthesia (seven cases, 63.6%), and muscle weakness (one case, 9.1%) on the contralateral side alone. Each case experienced ipsilateral hemilaminectomy and discectomy, and no lateral recess stenosis, hypertrophy of facets or ligaments, and sequestrated discs were found during surgery. All of them have good pain relief with two cases reporting no pain and nine cases reporting only mild pain at the last follow‐up. Conclusions Based on the surgical findings of our 11 LDH cases with contralateral symptoms, we hypothesized that the contralateral symptoms might be produced when the nerve root on the contralateral symptomatic side was tightly pulled by the herniated disc via the dural mater. Ipsilateral hemilaminectomy and discectomy surgery effectively and efficiently relieve the symptoms without postoperative complications for these patients.
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- 2023
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4. Long-term outcomes of the nano-hydroxyapatite/polyamide-66 cage versus the titanium mesh cage for anterior reconstruction of thoracic and lumbar corpectomy: a retrospective study with at least 7 years of follow-up
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Bowen Hu, Liang Wang, Yueming Song, Xi Yang, Limin Liu, and Chunguang Zhou
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Traumatic thoracolumbar fracture ,Anterior spinal fusion ,Long-term follow-up ,Nano hydroxyapatite/polyamide 66 (n-HA/PA66) cage ,Titanium mesh cage ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background The nano-hydroxyapatite/polyamide-66 (n-HA/PA66) cage is a biomimetic cage with a lower elastic modulus than the titanium mesh cage (TMC). This study aimed to compare the long-term outcomes of the n-HA/PA66 cage and TMC in the anterior reconstruction of thoracic and lumbar fractures. Methods We retrospectively studied 113 patients with acute traumatic thoracic or lumbar burst fractures, comprising 60 patients treated with the TMC and 53 treated with the n-HA/PA66 cage for anterior reconstruction following single-level corpectomy. The radiographic data (cage subsidence, fusion status, segmental sagittal alignment) and clinical data (visual analogue scale (VAS) for pain and Oswestry Disability Index (ODI) for function) were evaluated preoperatively, postoperatively, and at final follow-up after a minimum 7-year period. Results The n-HA/PA66 and TMC groups had similar final fusion rates (96.2% vs. 95.0%). The cage subsidence at final follow-up was 2.3 ± 1.6 mm with subsidence of more than 3 mm occurring in 24.5% in the n-HA/PA66 group, which was significantly lower than the respective values of 3.9 ± 2.5 mm and 58.3% in the TMC group. The n-HA/PA66 group also had better correction of the bisegmental kyphotic angle than the TMC group (7.1° ± 7.5° vs 1.9° ± 8.6°, p
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- 2023
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5. Multiple Hemivertebrae: The Natural History and Treatment of 50 Patients
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Bowen Hu, Linnan Wang, Yueming Song, Xi Yang, Limin Liu, and Chunguang Zhou
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Balanced hemivertebrae ,Congenital scoliosis ,Hemivertebra resection ,Posterior approach ,Unbalanced hemivertebrae ,Orthopedic surgery ,RD701-811 - Abstract
Objective Multiple hemivertebrae (MHV) is defined as three or more hemivertebrae, and is relatively uncommon among patients with congenital scoliosis. This study aimed to compare the natural history of different kinds of MHV and describe the surgical outcome of MHV. Methods In this retrospective cohort study, a total of 50 patients diagnosed with MHV were enrolled from June 2007 to June 2018. The medical records and radiographs of these patients were reviewed to summarize the characteristics of MHV. Patients with MHV were divided into the unbalanced (UB) group, partially unbalanced (PUB) group, and completely balanced (CB) group. Medical records and radiographs of MHV patients were reviewed to collect HV position, natural history, coronal and sagittal parameters. A Mann–Whitney U test was used to compare the radiographical data, such as the cobb angle of main curve and secondary curve, and Fisher's exact test was used to compare the patients in different kinds of MHV with surgical indication or not. Results The average number of hemivertebrae was 3.6 and the average main curve was 57.5°. Twenty‐four of 50 patients had associated anomalies, including four patients with sacral agenesis, one with tetralogy of Fallot, two with congenital imperforate anus, and 17 with Klippel‐Feil syndrome. In 22 patients who underwent MRI imaging, three patients had mild syringomyelia and three patients had diastematomyelia. The UB and PUB groups had a larger main curve and compensatory curve than the CB group. Of the 25 patients with follow‐up before surgery, the curve progression rate was highest in the UB group (12.1°/year) but similar in the PUB group (4.2°/year) and CB group (3.6°/year). All patients in the UB and PUB group met the criteria for surgery. In contrast, only 10 of 23 patients in the CB group had surgical indications. Eighteen of the 37 patients with surgical indications chose to undergo surgery and the correction rate of the main curve was 51.4%. Conclusions Early surgical intervention should be considered for most patients with UB or PUB MHV. For patients with CB MHV, surgical treatment may not be urgently needed at the first visit. Posterior hemivertebrectomy could be used for the treatment of MHV with satisfying radiographic outcome.
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- 2023
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6. Postoperative proximal junctional kyphosis correlated with thoracic inlet angle in Lenke 5c adolescent idiopathic scoliosis patients following posterior surgery
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Bowen Hu, Linnan Wang, Yueming Song, Xi Yang, Limin Liu, and Chunguang Zhou
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Proximal junctional kyphosis ,Thoracic inlet angle ,Adolescent idiopathic scoliosis ,Sagittal alignment ,Thoracolumbar/lumbar curve ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Proximal junctional kyphosis is a common complication after posterior fusion in patients with adolescent idiopathic scoliosis and is correlated with postoperative changes of thoracic kyphosis. In lenke 5c patients, higher postoperative LL and spontaneous change of TK may produce an effect on final PJK. However, no studies has been performed to evaluate the correlation of PJK with thoracocervical parameters in patients with AIS. Methods Data from 98 patients who underwent posterior fusion for Lenke 5C AIS with 2 years of follow-up were retrospectively reviewed. Patients in the extended fusion group underwent fusion at levels higher than upper-end vertebra + 2 (n = 38), and those in the thoracolumbar/lumbar (TL/L) fusion group underwent fusion at UEV + 2 or lower (n = 60). Results During an average follow-up of 38.1 months, 23 of 98 patients developed PJK. The extended fusion group had a higher incidence of PJK than the TL/L fusion group (14/38 vs. 9/60, respectively; P = 0.01) and a significantly greater decrease in thoracic kyphosis than the TL/L group (P 71° are more likely to develop PJK. Additionally, extended fusion in patients with Lenke 5C may increase the risk of PJK.
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- 2022
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7. Nomogram for predicting the distal adding-on phenomenon in severe and rigid scoliosis
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Zhongyang Li, Huiliang Yang, Chunguang Zhou, Peng Xiu, Xi Yang, Lei Wang, Ganjun Feng, Limin Liu, and Yueming Song
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distal adding-on ,nomogram ,internal distraction ,severe and rigid scoliosis ,scoliosis ,Surgery ,RD1-811 - Abstract
BackgroundThe distal adding-on phenomenon has attracted extensive discussion in the field of spine surgery due to the continual occurrence after scoliosis correction. Previous work has mainly focused on adolescent idiopathic scoliosis (AIS), and a relatively high number of theories for the mechanism of the distal adding-on phenomenon has been proposed for these kinds of patients. Severe and rigid scoliosis, as a special disease form, has a unique etiology, clinical manifestations and internal mechanisms distinct from those of AIS. Given the uniqueness of this disease, the mechanism and causes of the distal adding-on phenomenon have been infrequently studied in depth.ObjectiveTo define clinical and radiological factors associated with distal adding-on in patients with severe and rigid scoliosis.MethodsRadiographic parameters and demographic data of patients with severe and rigid scoliosis were evaluated preoperatively, after posterior instrumentation and fusion surgery, and at the final follow-up via radiographs. According to the appearance of distal adding-on at the final follow-up, the patients were grouped into the Adding-on and the Non-adding-on groups. Various radiological parameters were analyzed in stepwise multivariate logistic regression to identify the variables associated with distal adding-on, which were then incorporated into a nomogram. The predictive performance and calibration of the nomograms for distal adding-on were assessed using C statistics and calibration plots.Results93 patients (21 in the Adding-on and 72 in the Non-adding-on group) were included. The incidence of distal adding-on was 22.6%. The variables associated with distal adding-on were the anterior release, posterior internal distraction, and later posterior spinal fusion (IP) procedure, the posterior vertebral column resection and posterior spinal fusion (PVCR) procedure, postoperative apical vertebral translation (Post-AVT) and preoperative slope of the line linking the pedicles on the concave side of the upper- and lower-end vertebrae (Tan α). Combining these factors, the nomogram achieved a concordance index of 0.92 in predicting distal adding-on and had well-fitted calibration curves.ConclusionsFor patient with a negative Tanα in severe and rigid scoliosis, the risk of distal adding-on tended to increase, and it is recommended to give priority to IP or PVCR. In the final correction, a smaller Post-AVT should not be pursued excessively.
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- 2023
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8. Unplanned surgery of congenital scoliosis
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Huiliang Yang, Gihye Im, Ce Zhu, Camilo Osorio, Umar Masood, Chunguang Zhou, Xi Yang, Limin Liu, Yueming Song, and Ningning Wang
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Medicine - Published
- 2022
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9. As above, so below? The influence of leader humor on bootleg innovation: The mechanism of psychological empowerment and affective trust in leaders
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Xiong Zheng, Sheng Mai, Chunguang Zhou, Liang Ma, and Xiaomeng Sun
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leader humor ,bootleg innovation ,psychological empowerment ,trust in leader ,benign violation theory ,Psychology ,BF1-990 - Abstract
Leadership humor is widely used in management practice and has aroused extensive discussion in academia. On account of the two-sided influence of leader humor on employees, its double-edged sword effect on employee behavior has been put more emphasis. As a benign violation of organizational norms and a kind of pro-organizational violation, respectively, both Leadership humor and employee bootleg innovation have the characteristics of violating organizational norms, but few studies have examined the relationship between them. Based on benign violation theory and social cognition theory, this study conducted a two-stage questionnaire survey and statistical-econometric analysis of 324 employees in 23 IT and manufacturing technology companies in Guangdong, Jiangsu, Zhejiang, Hubei, Beijing, and Shanghai, China. It not only examined the relationship between leadership humor and employee bootleg innovation but also tested a moderated mediation model. Results show that leadership humor is positively correlated with psychological empowerment and employee bootleg innovation, namely, leadership humor indirectly and positively affects employee bootleg innovation through psychological empowerment. Moreover, the indirect effect is positively regulated by leadership emotional trust. The higher the emotional trust of employees to leadership, the stronger the mediating role of psychological empowerment between leader humor and bootleg innovation behavior. The study enriches the existing path of research on the double-edged impact of leader humor on employee behavior, expands the boundary conditions of the relationship between empowered cognitive mediation and employee bootleg innovation and provides enlightenments for Chinese leaders to effectively apply the tool of leader humor.
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- 2022
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10. Multifactor Analysis of Landslide Mechanisms: A Case Study of Yongji Expressway, China
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Qingfeng Meng, Xuyue Hu, Jing Zhang, Peng Li, Chunguang Zhou, and Zhi Wang
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Geology ,QE1-996.5 - Abstract
Based on deformation monitoring and stability results obtained from geological mapping, geological drilling, macrolaboratory, and microlaboratory tests, the sliding mechanism of landslide in Guzhang County of Yongji expressway was studied. The bedding slope landslide results from cutting slope along the central white mud clay slip, and by on-site investigation and deep displacement monitoring, the clay is determined as the landslide surface. Combining the experimental results and similar geotechnical engineering experience, by back-calculation, the parameters of the soft interlayer are calculated as C(5 kPa) and ϕ (8.5°). Based on X-ray diffraction (XRD) and X-ray fluorescence spectroscopy (XRF) test, the results are concluded that the chlorite in clay interlayer is easily water softened, excavation slope after long-term heavy rainfall chlorite clay interlayer softening. Sustained rainfall and underground water levels showed a positive correlation when the slope is sliding, and the heavy rainfall continued to accelerate slope sliding. Furthermore, the slope surface displacement and profound displacement increase quickly, and rainfall and slope displacement also showed a positive correlation.
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- 2022
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11. Inhibition of PARP Potentiates Immune Checkpoint Therapy through miR-513/PD-L1 Pathway in Hepatocellular Carcinoma
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Guoqiang Sun, Ganggang Miao, Zhitao Li, Wubin Zheng, Chunguang Zhou, Guangshun Sun, Hongyong Cao, Zhouxiao Li, and Weiwei Tang
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Oncology ,Article Subject - Abstract
Background. The DNA repair enzyme poly(ADP-ribose) polymerase (PARP) is involved in DNA damage repair and cell death. However, the association between PARP’s biological activities and the immune microenvironment in hepatocellular carcinoma (HCC) is unclear. The present study will explore whether combining a PARP inhibitor with anti-PD1 might improve the anti-HCC impact and explain how it works. Method. The PARP inhibitor olaparib was screened out of 867 drugs through Cell Counting Kit 8 (CCK-8) assay. The expression of PARP was verified through the TCGA and TISIDB databases. The impacts exerted by PARP inhibitor olaparib to HCC cells were assessed via wound healing, Transwell, and proliferation assay. In vivo, experiments were performed in a C57BL/6 mouse model to evaluate the function of PARP inhibitor olaparib combination with anti-PD1 in HCC and mice tumors were further detected by immunohistochemically staining. Result. Olaparib was selected as the research object on the basis of drug screening. The results of the TCGA and Human Protein Atlas databases revealed that PARP was significantly upregulated in carcinoma cell cluster of HCC tissues compared to normal tissues. Higher expression of PARP showed a poorer prognosis based on Kaplan-Meier Plotter. qRT-PCR experiments confirmed that olaparib could increase PD-L1 expression through inhibiting miR-513 in HCC cells. In vivo, experiment confirmed that the combination of olaparib and anti-PD1 could enhance the immunotherapy effect of HCC. Conclusion. The present study reveals that inhibition of PARP potentiates immune checkpoint therapy through the miR-513/PD-L1 pathway in HCC and the combination of PARP inhibitor olaparib and anti-PD1 is beneficial to HCC therapy.
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- 2022
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12. Fusion of parathyroid hormone (1–34) to an albumin-binding domain improves osteogenesis
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Dongzhi Xu, Haihao Wu, and Chunguang Zhou
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Pharmaceutical Science - Published
- 2023
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13. The Comparison of Convolutional Neural Networks and the Manual Measurement of Cobb Angle in Adolescent Idiopathic Scoliosis
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Xianming Huang, Ming Luo, Limin Liu, Diwei Wu, Xuanhe You, Zhipeng Deng, Peng Xiu, Xi Yang, Chunguang Zhou, Ganjun Feng, Lei Wang, Zhongjie Zhou, Jipeng Fan, Mingjie He, Zhongjun Gao, Lixin Pu, Zhihong Wu, Zongke Zhou, Yueming Song, and Shishu Huang
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Orthopedics and Sports Medicine ,Surgery ,Neurology (clinical) - Abstract
Study Design Comparative study Objective To compare manual and deep learning-based automated measurement of Cobb angle in adolescent idiopathic scoliosis. Methods We proposed a fully automated framework to measure the Cobb angle of AIS patients. Whole-spine images of 500 AIS individuals were collected. 200 digital radiographic (DR) images were labeled manually as training set, and the remaining 300 images were used to validate by mean absolute error (MAE), Pearson or spearman correlation coefficients, and intra/interclass correlation coefficients (ICCs). The relationship between accuracy of vertebral boundary identification and the subjective image quality score was evaluated. Results The PT, MT, and TL/L Cobb angles were measured by the automated framework within 300 milliseconds. Remarkable 2.92° MAE, .967 ICC, and high correlation coefficient (r = .972) were obtained for the major curve. The MAEs of PT, MT, and TL/L were 3.04°, 2.72°, and 2.53°, respectively. The ICCs of these 3 curves were .936, .977, and .964, respectively. 88.7% (266/300) of cases had a difference range of ±5°, with 84.3% (253/300) for PT, 89.7% (269/300) for MT, and 93.0% (279/300) for TL/L. The decreased bone/soft tissue contrast (2.94 vs 3.26; P=.039) and bone sharpness (2.97 vs 3.35; P=.029) were identified in the images with MAE exceeding 5°. Conclusion The fully automated framework not only identifies the vertebral boundaries, vertebral sequences, the upper/lower end vertebras and apical vertebra, but also calculates the Cobb angle of PT, MT, and TL/L curves sequentially. The framework would shed new light on the assessment of AIS curvature.
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- 2022
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