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2. The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos C., Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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4. Correction: ASO Visual Abstract: The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos, Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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5. Correction: ASO Author Reflections: The Number of Involved Structures is a Promising Prognostic Factor in Thymic Epithelial Tumors

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos, Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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6. Correction: The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos C., Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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7. ASO Visual Abstract: The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos, Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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8. ASO Author Reflections: The Number of Involved Structures is a Promising Prognostic Factor in Thymic Epithelial Tumors

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos, Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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9. Survival Outcome After Surgery in Patients With Thymoma Distant Recurrence

Author

Chiappetta, Marco, Sassorossi, Carolina, Nachira, Dania, Lococo, Filippo, Meacci, Elisa, Ruffini, Enrico, Guerrera, Francesco, Lyberis, Paraskevas, Aprile, Vittorio, Lucchi, Marco, Ambrogi, Marcello Carlo, Bacchin, Diana, Dell’Amore, Andrea, Marino, Carlotta, Comacchio, Giovannimaria, Roca, Gabriella, Rea, Federico, and Margaritora, Stefano

Published
2024
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10. Correction: Lung cancer multi-omics digital human avatars for integrating precision medicine into clinical practice: the LANTERN study

Author

Lococo, Filippo, Boldrini, Luca, Diepriye, Charles-Davies, Evangelista, Jessica, Nero, Camilla, Flamini, Sara, Minucci, Angelo, De Paolis, Elisa, Vita, Emanuele, Cesario, Alfredo, Annunziata, Salvatore, Calcagni, Maria Lucia, Chiappetta, Marco, Cancellieri, Alessandra, Larici, Anna Rita, Cicchetti, Giuseppe, Troost, Esther G. C., Ádány, Róza, Farré, Núria, Öztürk, Ece, Van Doorne, Dominique, Leoncini, Fausto, Urbani, Andrea, Trisolini, Rocco, Bria, Emilio, Giordano, Alessandro, Rindi, Guido, Sala, Evis, Tortora, Giampaolo, Valentini, Vincenzo, Boccia, Stefania, Margaritora, Stefano, and Scambia, Giovanni

Published
2023
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11. Lung cancer multi-omics digital human avatars for integrating precision medicine into clinical practice: the LANTERN study

Author

Lococo, Filippo, Boldrini, Luca, Diepriye, Charles-Davies, Evangelista, Jessica, Nero, Camilla, Flamini, Sara, Minucci, Angelo, De Paolis, Elisa, Vita, Emanuele, Cesario, Alfredo, Annunziata, Salvatore, Calcagni, Maria Lucia, Chiappetta, Marco, Cancellieri, Alessandra, Larici, Anna Rita, Cicchetti, Giuseppe, Troost, Esther G.C., Ádány, Róza, Farré, Núria, Öztürk, Ece, Van Doorne, Dominique, Leoncini, Fausto, Urbani, Andrea, Trisolini, Rocco, Bria, Emilio, Giordano, Alessandro, Rindi, Guido, Sala, Evis, Tortora, Giampaolo, Valentini, Vincenzo, Boccia, Stefania, Margaritora, Stefano, and Scambia, Giovanni

Published
2023
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13. Surgeon experience influence lymphadenectomy during VATS lobectomy: National VATS database results

Author

Maurizio, Mancuso, Fausto, Pernazza, Majed, Refai, Franco, Stella, Desideria, Argnani, Giuseppe, Marulli, Angela, De Palma, Luigi, Bortolotti, Giovanna, Rizzardi, Piergiorgio, Solli, Giampiero, Dolci, Reinhold, Perkmann, Francesco, Zaraca, Roberto, Benvenuti Mauro, Diego, Gavezzoli, Roberto, Cherchi, Albino, Ferrari Paolo, Felice, Mucilli, Pierpaolo, Camplese, Giulio, Melloni, Federico, Mazza, Giorgio, Cavallesco, Pio, Maniscalco, Luca, Voltolini, Alessandro, Gonfiotti, Francesco, Sollitto, Pia, Ardò Nicoletta, Luca, Pariscenti Gian, Carlo, Risso, Corrado, Surrente, Camillo, Lopez, Andrea, Droghetti, Michele, Giovanardi, Cristiano, Breda, Fabio, Lo Giudice, Marco, Alloisio, Edoardo, Bottoni, Lorenzo, Spaggiari, Roberto, Gasparri, Massimo, Torre, Alessandro, Rinaldo, Mario, Nosotti, Davide, Tosi, Giampeiro, Negri, Alessandro, Bandiera, Alessandro, Baisi, Federico, Raveglia, Alessandro, Stefani, Pamela, Natali, Marco, Scarci, Emanuele, Pirondini, Carlo, Curcio, Dario, Amore, Ottavio, Rena, Samuele, Nicotra, Andrea, Dell' Amore, Alessandro, Bertani, Giorgia, Tancredi, Luca, Ampollini, Paolo, Carbognani, Francesco, Puma, Damiano, Vinci, Giuseppe, Cardillo, Francesco, Carleo, Nachira, Dania, Piero, Paladini, Marco, Ghisalberti, Roberto, Crisci, Duilio, Divisi, Diego, Fontana, Vittorio, Della Beffa, Angelo, Morelli, Francesco, Londero, Andrea, Imperatori, Nicola, Rotolo, Alberto, Andrea, Viti, Maurizio, Infante, Cristiano, Benato, Chiappetta, Marco, Sassorossi, Carolina, Lococo, Filippo, Curcio, Carlo, Crisci, Roberto, Sperduti, Isabella, Meacci, Elisa, and Margaritora, Stefano

Published
2024
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15. Salvage Surgery After First-Line Alectinib for Locally-Advanced/Metastatic ALK-Rearranged NSCLC: Pathological Response and Perioperative Results

Author

Lococo, Filippo, Cancellieri, Alessandra, Chiappetta, Marco, Leonetti, Alessandro, Cardillo, Giuseppe, Zanelli, Francesca, Mangiameli, Giuseppe, Toschi, Luca, Guggino, Gianluca, Romano, Francesco Jacopo, Leuzzi, Giovanni, Proto, Claudia, Spaggiari, Lorenzo, De Marinis, Filippo, Vita, Emanuele, Ampollini, Luca, Margaritora, Stefano, Tiseo, Marcello, and Bria, Emilio

Published
2023
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16. Role of Peripheral Blood Markers for Detecting Response and Predicting Prognosis in Patients with Non-small-cell Lung Cancer Undergoing Neoadjuvant Therapy and Surgery

Author

Lococo, Filippo, Chiappetta, Marco, Evangelista, Jessica, Sperduti, Isabella, Nachira, Dania, Porziella, Venanzio, and Congedo, Maria Teresa

Subjects
Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Cancer -- Adjuvant treatment, Neoadjuvant therapy -- Health aspects, Lung cancer, Non-small cell -- Prognosis, Surgery -- Health aspects, Health
Abstract

Introduction To date, no validated predictors of response before neoadjuvant therapy (NAD) are currently available in locally advanced non-small-cell lung cancer (NSCLC). In this study, different peripheral blood markers were investigated before NAD (pre-NAD) and after NAD/before surgery (post-NAD) to evaluate their influence on the treatment outcomes. Methods Patients affected by locally advanced NSCLC (cT1-T4/N0-2/M0) who underwent NAD followed by surgery from January 1996 to December 2019 were considered for this retrospective analysis. The impact of peripheral blood markers on downstaging post-NAD and on overall survival (OS) was evaluated using multivariate logistic and Cox regression models. Time to event analysis was performed by means of Kaplan-Meier survival curves and Log Rank tests at 5 years from surgery. Results Two hundred and seventy-two consecutive patients were included. Most of the patients had Stage III NSCLC (83.5%). N2 disease was reported in 188 (69.1%) patients. Surgical resection was performed in patients with stable disease or downstaging post-NAD. Nodal downstaging was observed in 80% of clinical N2 (cN2) patients. The median follow-up of the total series was 74 months (range 6-302). Five-year OS in the overall population and in N2 population was 74.6% and 73.5%, respectively. The pre-surgery platelets level (PLT) (p = 0.019) and the variation (pre-NAD/post-NAD) of the neutrophil/lymphocyte ratio (p = 0.024) were identified as independent prognostic factors of OS. The preoperative PLT value (p value = 0.031) was confirmed as the only predictor of NAD response. Conclusions The clinical role of peripheral blood markers in locally advanced NSCLC needs to be further investigated. Based on these preliminary results, these factors may be used as auxiliary markers for the prediction of response to neoadjuvant treatment and as prognostic factors for stratification in multimodal approaches., Author(s): Filippo Lococo [sup.1] [sup.2], Marco Chiappetta [sup.1] [sup.2], Jessica Evangelista [sup.2], Isabella Sperduti [sup.3], Dania Nachira [sup.1] [sup.2], Venanzio Porziella [sup.1] [sup.2], Maria Teresa Congedo [sup.1] [sup.2], Emilio Bria [...]

Published
2022
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19. Uniportal Laser-Assisted Video-Assisted Thoracoscopy (U-LA-VATS) for Lung Metastasectomy: Technical Description, Peri-Operative Results and Pertinent Literature Review.

Author

Sassorossi, Carolina, Chiappetta, Marco, Nachira, Dania, Campanella, Annalisa, Santoro, Gloria, Calabrese, Giuseppe, Scognamiglio, Chiara, Napolitano, Antonio Giulio, Senatore, Alessia, Petracca Ciavarella, Leonardo, Vita, Maria Letizia, Margaritora, Stefano, and Lococo, Filippo

Subjects
*VIDEO-assisted thoracic surgery, *LASER surgery, *SURGICAL margin, *LUNG surgery, *SURGICAL complications
Abstract

Pulmonary metastasectomy (PM) is a well-established treatment that is able to contribute to the cure of oligometastatic cancer. Surgery should adopt the most lung-sparing approach possible to preserve pulmonary function (and, consequently, the quality of life) and to spare the lung for potential additional lung resections. In this framework, laser technology has been introduced in recent decades, but only few experiences combining laser technology with VATS approaches have been reported till now. The main focus of this manuscript is to report our institutional experience in performing lung-sparing laser-assisted PM by uniportal VATS (uniportal laser-assisted VATS: U-LA-VATS). The surgical technique and peri-operative results from our series of patients were herein presented and compared with the pertinent literature. Methods: Between March 2021 and November 2023, among 98 patients who underwent PM, a total of 24 patients (18 men (75%); 6 women (25%); mean age 61.4 years; age range 13–83 years) were treated with laser-assisted PM at our institution. Patients who underwent anatomical resection were excluded for the purpose of the analysis. The U-LA-VATS procedure adopted a modified laser-assisted lung resection technique for performing PM via VATS. Dedicated instruments are used, characterized by a long shape and a curved shape, with distal and proximal articulations. A surgical laser system (Thulium + Diodo OUTPUT 30–10 W, Quanta System S.p.a., Solbiate Olona, Italy) was used, and a 550-μm sterile optical fibre conducted through a specific thoracoscopic handpiece was introduced in the lowest part of the incision. Peri-operative results were analysed in all cohort and compared according to the surgical technique. Moreover, these results were compared with those reported in the literature. Comprehensive research of the literature was conducted on PubMed from 2000 to 2024. A review was performed and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: In 12 cases (50%), thulium laser-assisted resection was performed using uniportal video-assisted thoracic surgery (VATS), and in the other cases (12, 50%), a (mini)thoracotomy access was adopted. In the thoracotomy group, the mean duration of surgery was 95 ± 57.7 min; meanwhile, it was 73.5 ± 35.5 in the uniportal VATS group. At the univariate analysis, this difference resulted to be statistically significant (p value 0.025). We did not observe intra-operative complications or remarkable malfunction of the laser system. We also did not report major complications after surgery; also the air-leak rate was 8.3% and 0% after thoracotomic and VATS procedures, respectively. Surgical margins were free from disease in all cases. Major and minor post-op complication rates were similar in both groups. The mean hospitalization after surgery was 2.9 ± 0.3 days for the uniportal VATS group and 3.7 ± 0.9 days for the thoracotomy group, this difference being statistically significant at the univariate analysis (p value = 0.015). Conclusions: U-LA-VATS is a safe and effective procedure, able to combine a parenchymal sparing exeresis with a mini-invasive approach. This procedure is associated with a shorter hospital stay compared with PM performed by a thoracotomic approach. Compared with the selected works for the review, our series is the only one describing the use of laser resection combined with a uniportal VATS approach. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Comparative Analysis of Comprehensive Genomic Profile in Thymomas and Recurrent Thymomas Reveals Potentially Actionable Mutations for Target Therapies.

Author

Lococo, Filippo, De Paolis, Elisa, Evangelista, Jessica, Dell'Amore, Andrea, Giannarelli, Diana, Chiappetta, Marco, Campanella, Annalisa, Sassorossi, Carolina, Cancellieri, Alessandra, Calabrese, Fiorella, Conca, Alessandra, Vita, Emanuele, Minucci, Angelo, Bria, Emilio, Castello, Angelo, Urbani, Andrea, Rea, Federico, Margaritora, Stefano, and Scambia, Giovanni

Subjects
GENETIC profile, PROPENSITY score matching, GENOMICS, CELL cycle, INDIVIDUALIZED medicine
Abstract

Molecular profiles of thymomas and recurrent thymomas are far from being defined. Herein, we report an analysis of a comprehensive genetic profile (CGP) in a highly selected cohort of recurrent thymomas. Among a cohort of 426 thymomas, the tissue was available in 23 recurrent tumors for matching the biomolecular results obtained from primary and relapse samples. A control group composed of non-recurrent thymoma patients was selected through a propensity score match analysis. CGP was performed using the NGS Tru-SightOncology assay to evaluate TMB, MSI, and molecular alterations in 523 genes. CGP does not differ when comparing initial tumor with tumor relapse. A significantly higher frequency of cell cycle control genes alterations (100.0% vs. 57.1%, p = 0.022) is detected in patients with early recurrence (<32 months) compared to late recurrent cases. The CGPs were similar in recurrent thymomas and non-recurrent thymomas. Finally, based on NGS results, an off-label treatment or clinical trial could be potentially proposed in >50% of cases (oncogenic Tier-IIC variants). In conclusion, CGPs do not substantially differ between initial tumor vs. tumor recurrence and recurrent thymomas vs. non-recurrent thymomas. Cell cycle control gene alterations are associated with an early recurrence after thymectomy. Multiple target therapies are potentially available by performing a comprehensive CGP, suggesting that a precision medicine approach on these patients could be further explored. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Implementation of Artificial Intelligence in Personalized Prognostic Assessment of Lung Cancer: A Narrative Review

Author

Lococo, Filippo, primary, Ghaly, Galal, additional, Chiappetta, Marco, additional, Flamini, Sara, additional, Evangelista, Jessica, additional, Bria, Emilio, additional, Stefani, Alessio, additional, Vita, Emanuele, additional, Martino, Antonella, additional, Boldrini, Luca, additional, Sassorossi, Carolina, additional, Campanella, Annalisa, additional, Margaritora, Stefano, additional, and Mohammed, Abdelrahman, additional

Published
2024
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22. Uniportal Video-Assisted Thoracoscopic Surgery Completion Lobectomy Long after Wedge Resection or Segmentectomy in the Same Lobe: A Bicenter Study

Author

Meacci, Elisa, primary, Refai, Majed, additional, Nachira, Dania, additional, Salati, Michele, additional, Kuzmych, Khrystyna, additional, Tabacco, Diomira, additional, Zanfrini, Edoardo, additional, Calabrese, Giuseppe, additional, Napolitano, Antonio Giulio, additional, Congedo, Maria Teresa, additional, Chiappetta, Marco, additional, Petracca-Ciavarella, Leonardo, additional, Sassorossi, Carolina, additional, Andolfi, Marco, additional, Xiumè, Francesco, additional, Tiberi, Michela, additional, Guiducci, Gian Marco, additional, Vita, Maria Letizia, additional, Roncon, Alberto, additional, Nanto, Anna Chiara, additional, and Margaritora, Stefano, additional

Published
2024
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23. Neutrophil-to-Lymphocyte Ratio and Risk of Nodal Metastasis in Early-Stage Lung Adenocarcinoma: A Brief Report From a Multicentric Analysis

Author

Gallina, Filippo Tommaso, primary, Chiappetta, Marco, additional, Tajè, Riccardo, additional, Forcella, Daniele, additional, Sassorossi, Carolina, additional, Congedo, Maria Teresa, additional, Evangelista, Jessica, additional, Sperduti, Isabella, additional, Lococo, Filippo, additional, Cappuzzo, Federico, additional, Melis, Enrico, additional, Margaritora, Stefano, additional, and Facciolo, Francesco, additional

Published
2024
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25. Surgeon experience influence lymphadenectomy during VATS lobectomy: National VATS database results

Author

Chiappetta, Marco, Sassorossi, Carolina, Lococo, Filippo, Curcio, Carlo, Crisci, Roberto, Sperduti, Isabella, Meacci, Elisa, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Meacci, Elisa (ORCID:0000-0001-8424-3816), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Chiappetta, Marco, Sassorossi, Carolina, Lococo, Filippo, Curcio, Carlo, Crisci, Roberto, Sperduti, Isabella, Meacci, Elisa, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Meacci, Elisa (ORCID:0000-0001-8424-3816), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)

Abstract

Objectives: Aim of this study is to identify the factors that may influence the lymphadenectomy during VATS anatomical lung resection with particular interest on operator experience. Materials and methods: Clinical and pathological data from the prospective VATS Italian nationwide registry were reviewed and analysed. Patients with incomplete data regarding tumor and surgical characteristics, GGO, or with distant metastases were excluded. Patients clinical data, tumor characteristics, operation information and surgeon experience were collected and compared to resected lymph nodes number (#RN), resected N2 nodes number (#N2RN) and resected N2 stations number. A multivariable model was built using logistic regression analysis. Surgeon experience was categorized considering the number of VATS major anatomical resection and years after residency. Results: The final analysis was conducted on 3727 patients. The median #RN and #N2RN were 11 (1-51) and 5 (0-41). Regarding the analysed outcomes, #N2RN > 6 resulted in 1812 (48.8%)cases, #RN > 10 in 2124 (57.0%)cases and more than 3 N2 stations were harvested in 1447 (38.8%)patients. First operator experience with number of VATS lobectomies>50 (p < 0.001), operator seniority after residency5-10years (p < 0.001), cTNM II/III(p = 0.017), lobectomy/bilobectomy vs segmentectomy (p < 0.001), and upper/middle lobe tumor location (p < 0.005)resulted significantly associated to #N2RN > 6 at the multivariable analysis. First operator experience with number of VATS lobectomies>50 (p < 0.001), operator seniority after residency5-10years (p < 0.001) and lobectomy/bilobectomy (p < 0.001) resulted significantly associated to #RN > 10 at the multivariable analysis. Conclusions: Our study showed that lymphadenectomy during VATS lobectomy is influenced by tumor factors such as c

Published
2024

26. BRCA1‐associated protein 1: Tumor predisposition syndrome and Kury‐Isidor syndrome, from genotype–phenotype correlation to clinical management.

Author

West, Elizabeth Casey, Chiappetta, Marco, Mattingly, Aubrey Anne, Congedo, Maria Teresa, Evangelista, Jessica, Campanella, Annalisa, Sassorossi, Carolina, Flamini, Sara, Rossi, Teresa, Pistoni, Mariaelena, Abenavoli, Ludovico, Margaritora, Stefano, Lococo, Filippo, and Boccuto, Luigi

Subjects
*DNA repair, *TUMOR proteins, *TUMOR suppressor genes, *GENETIC counseling, *SYNDROMES
Abstract

The BAP1 tumor suppressor gene encodes a deubiquitinase enzyme involved in several cellular activities, including DNA repair and apoptosis. Germline pathogenic variants in BAP1 have been associated with heritable conditions including BAP1 tumor predisposition syndrome 1 (BAP1‐TPDS1) and a neurodevelopmental disorder known as Kury‐Isidor syndrome (KURIS). Both these conditions are caused by monoallelic, dominant alterations of BAP1 but have never been reported in the same subject or family, suggesting a mutually exclusive genotype–phenotype correlation. This distinction is extremely important considering the early onset and aggressive nature of the types of cancer reported in individuals with TPDS1. Genetic counseling in subjects with germline BAP1 variants is fundamental to predicting the effect of the variant and the expected phenotype, assessing the potential risk of developing cancer for the tested subject and the family members who may carry the same variant and providing the multidisciplinary clinical team with the proper information to establish precise surveillance and management protocols. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Are the Efficacy and Safety of Chest Tubes in Uniportal Video-Assisted Thoracic Surgery Related to the Level of Intercostal Space Insertion or to the Drain Type? A Prospective Multicenter Study

Author

Nachira, Dania, primary, Bertoglio, Pietro, additional, Ismail, Mahmoud, additional, Napolitano, Antonio Giulio, additional, Calabrese, Giuseppe, additional, Kuzmych, Khrystyna, additional, Congedo, Maria Teresa, additional, Sassorossi, Carolina, additional, Meacci, Elisa, additional, Petracca Ciavarella, Leonardo, additional, Chiappetta, Marco, additional, Lococo, Filippo, additional, Solli, Piergiorgio, additional, and Margaritora, Stefano, additional

Published
2024
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28. The genetic susceptibility in the development of malignant pleural mesothelioma: somatic and germline variants, clinicopathological features and implication in practical medical/surgical care: a narrative review

Author

Congedo, Maria Teresa, primary, West, Elizabeth Casey, additional, Evangelista, Jessica, additional, Mattingly, Aubrey Anne, additional, Calabrese, Giuseppe, additional, Sassorossi, Carolina, additional, Nocera, Adriana, additional, Chiappetta, Marco, additional, Flamini, Sara, additional, Abenavoli, Ludovico, additional, Margaritora, Stefano, additional, Boccuto, Luigi, additional, and Lococo, Filippo, additional

Published
2024
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29. Unsolved Issues in Thymic Epithelial Tumour Stage Classification: The Role of Tumour Dimension

Author

Sassorossi, Carolina, primary, Bertoglio, Pietro, additional, Lococo, Filippo, additional, Santoro, Gloria, additional, Meacci, Elisa, additional, Nachira, Dania, additional, Congedo, Maria Teresa, additional, Brandolini, Jury, additional, Petroncini, Matteo, additional, Nocera, Adriana, additional, Charles-Davies, Diepriye, additional, Solli, Piergiorgio, additional, Margaritora, Stefano, additional, and Chiappetta, Marco, additional

Published
2023
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33. Surgical Resection of Pulmonary Metastases from Melanoma in Oligometastatic Patients: Results from a Multicentric Study in the Era of Immunoncology and Targeted Therapy

Author

Meacci, Elisa, primary, Nachira, Dania, additional, Congedo, Maria Teresa, additional, Ibrahim, Mohsen, additional, Pariscenti, Gianluca, additional, Petrella, Francesco, additional, Casiraghi, Monica, additional, De Stefani, Alessandro, additional, del Regno, Laura del, additional, Peris, Ketty, additional, Triumbari, Elizabeth Katherine Anna, additional, Schinzari, Giovanni, additional, Rossi, Ernesto, additional, Petracca-Ciavarella, Leonardo, additional, Vita, Maria Letizia, additional, Chiappetta, Marco, additional, Siciliani, Alessandra, additional, Peritore, Valentina, additional, Manitto, Mattia, additional, Morelli, Lucia, additional, Zanfrini, Edoardo, additional, Tabacco, Diomira, additional, Calabrese, Giuseppe, additional, Bardoni, Claudia, additional, Evangelista, Jessica, additional, Spaggiari, Lorenzo, additional, and Margaritora, Stefano, additional

Published
2023
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34. Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study

Author

Sassorossi, Carolina, primary, Congedo, Maria Teresa, additional, Nachira, Dania, additional, Tabacco, Diomira, additional, Chiappetta, Marco, additional, Evangelista, Jessica, additional, di Gioia, Adele, additional, Di Resta, Velia, additional, Sorino, Claudio, additional, Mondoni, Michele, additional, Leoncini, Fausto, additional, Calabrese, Giuseppe, additional, Napolitano, Antonio Giulio, additional, Nocera, Adriana, additional, Lococo, Achille, additional, Margaritora, Stefano, additional, and Lococo, Filippo, additional

Published
2023
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35. Salvage surgery after first-line Alectinib for locally-advanced/metastatic ALK-rearranged NSCLC: pathological response and peri-operative results

Author

Lococo, Filippo, primary, Cancellieri, Alessandra, additional, Chiappetta, Marco, additional, Leonetti, Alessandro, additional, Cardillo, Giuseppe, additional, Zanelli, Francesca, additional, Mangiameli, Giuseppe, additional, Toschi, Luca, additional, Guggino, Gianluca, additional, Romano, Francesco, additional, Leuzzi, Giovanni, additional, Proto, Claudia, additional, Spaggiari, Lorenzo, additional, De Marinis, Filippo, additional, Vita, Emanuele, additional, Ampollini, Luca, additional, Margaritora, Stefano, additional, Tiseo, Marcello, additional, and Bria, Emilio, additional

Published
2023
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36. Association of the Extent of Resection with Survival in Multiple Primary Lung Cancer: A Systematic Review

Author

Tamburini, Nicola, Bombardini, Cristina, Chiappetta, Marco, Maniscalco, Pio, Valpiani, Giorgia, Cesario, Alfredo, Cirocchi, Roberto, Anania, Gabriele, Stefanelli, Antonio, Cavallesco, Giorgio, Margaritora, Stefano, Lococo, Filippo, Cesario, Alfredo (ORCID:0000-0003-4687-0709), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Lococo, Filippo (ORCID:0000-0002-9383-5554), Tamburini, Nicola, Bombardini, Cristina, Chiappetta, Marco, Maniscalco, Pio, Valpiani, Giorgia, Cesario, Alfredo, Cirocchi, Roberto, Anania, Gabriele, Stefanelli, Antonio, Cavallesco, Giorgio, Margaritora, Stefano, Lococo, Filippo, Cesario, Alfredo (ORCID:0000-0003-4687-0709), Margaritora, Stefano (ORCID:0000-0002-9796-760X), and Lococo, Filippo (ORCID:0000-0002-9383-5554)

Abstract

Background The incidence of synchronous multiple primary lung cancer (SMPLC) has progressively increased, due to recent advances in imaging. To date, no guidelines defining recommendations for patients' selection and no standard treatment of cases with SMPLC have been defined. The primary aim of this systematic review was to assess survival among patients treated with lobectomy or sublobar resection MPLC. Methods Comprehensive literature search of Medline, the Cochrane Library, reference lists, and ongoing studies was performed according to a prospectively registered design (PROSPERO: CRD42019115487). All studies published between 1998 and December 2020 that examined treatments with lobectomy compared to sublobar resection were included. Two double-blind investigators independently selected articles. Primary outcomes were to assess the 5-year overall survival (OS) rate among patients treated with lobectomy or sublobar resection and the impact of lymph node status on 5-year OS and 5-year disease-free survival in patients with MPLC. Results The search yielded 424 articles; 4 observational studies met the inclusion criteria and collectively evaluated 298 patients with a mean age ranging from 61.5 to 67 years. A total of 112 patients were treated for bilateral synchronous tumors and 186 patients for unilateral multiple synchronous tumors. All included studies showed that the type of resection, lobectomy or limited resection, had no significant impact on survival. Conclusion Limited resection is a valuable treatment option for MPLC. However, the clinical level of evidence of the studies found is low and randomized studies are needed to clarify the extent of resection in MPLC.

Published
2023

37. A prognostic score from a multicentric retrospective analysis of patients affected by sarcoma with metachronous lung metastases undergoing metastasectomy

Author

Gallina, Filippo Tommaso, Melis, Enrico, Bertolaccini, Luca, Spaggiari, Lorenzo, Rocca, Michele, Donati, Davide Maria, Chiappetta, Marco, Margaritora, Stefano, Bertoglio, Pietro, Solli, Piergiorgio, Mammana, Marco, Rea, Federico, Onesti, Elisa Concetta, Ferraresi, Virginia, Sperduti, Isabella, Ciliberto, Gennaro, Facciolo, Francesco, Margaritora, Stefano (ORCID:0000-0002-9796-760X), Gallina, Filippo Tommaso, Melis, Enrico, Bertolaccini, Luca, Spaggiari, Lorenzo, Rocca, Michele, Donati, Davide Maria, Chiappetta, Marco, Margaritora, Stefano, Bertoglio, Pietro, Solli, Piergiorgio, Mammana, Marco, Rea, Federico, Onesti, Elisa Concetta, Ferraresi, Virginia, Sperduti, Isabella, Ciliberto, Gennaro, Facciolo, Francesco, and Margaritora, Stefano (ORCID:0000-0002-9796-760X)

Abstract

BackgroundDespite the lack of evidence-based on prospective randomized studies, surgery has become the cornerstone of the treatment in patients with pulmonary oligometastatic sarcomas. Our study aimed to construct a composite prognostic score for metachronous oligometastatic sarcoma patients. MethodsA retrospective analysis was performed on data patients who underwent radical surgery for metachronous metastases in six research institutes from January 2010 to December 2018. The log-hazard ratio (HR) obtained from the Cox model was used to derive weighting factors for a continuous prognostic index designed to identify differential outcome risks. ResultsA total of 251 patients were enrolled in the study. In the multivariate analysis, a longer disease-free interval (DFI) and a lower neutrophil-to-lymphocytes ratio (NLR) were predictive of a better overall survival (OS) and disease-free survival (DFS). A prognostic score was developed based on DFI and NLR data, identifying 2 risk class groups for DFS (3-years DFS 20.2% for the high-risk group [HRG]and 46.4% for the low-risk group [LRG] [<0.0001]) and 3 risk groups for OS (3 years OS 53.9% for the HRG vs. 76.9% for the intermediate-risk group and 100% of the LRG (p < 0.0001)). ConclusionThe proposed prognostic score effectively predicts outcomes for patients with lung metachronous oligo-metastases from the surgically treated sarcoma.

Published
2023

39. Uniportal-VATS vs. open McKeown esophagectomy: Surgical and long-term oncological outcomes

Author

Nachira, Dania, primary, Congedo, Maria Teresa, additional, Calabrese, Giuseppe, additional, Tabacco, Diomira, additional, Petracca Ciavarella, Leonardo, additional, Meacci, Elisa, additional, Vita, Maria Letizia, additional, Punzo, Giovanni, additional, Lococo, Filippo, additional, Raveglia, Federico, additional, Chiappetta, Marco, additional, Porziella, Venanzio, additional, Guttadauro, Angelo, additional, Cioffi, Ugo, additional, and Margaritora, Stefano, additional

Published
2023
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40. A prognostic score from a multicentric retrospective analysis of patients affected by sarcoma with metachronous lung metastases undergoing metastasectomy

Author

Gallina, Filippo Tommaso, primary, Melis, Enrico, additional, Bertolaccini, Luca, additional, Spaggiari, Lorenzo, additional, Rocca, Michele, additional, Donati, Davide Maria, additional, Chiappetta, Marco, additional, Margaritora, Stefano, additional, Bertoglio, Pietro, additional, Solli, Piergiorgio, additional, Mammana, Marco, additional, Rea, Federico, additional, Onesti, Elisa Concetta, additional, Ferraresi, Virginia, additional, Sperduti, Isabella, additional, Ciliberto, Gennaro, additional, and Facciolo, Francesco, additional

Published
2023
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43. Is PET/CT Able to Predict Histology in Thymic Epithelial Tumours? A Narrative Review

Author

Chiappetta, Marco, primary, Mendogni, Paolo, additional, Cattaneo, Margherita, additional, Evangelista, Jessica, additional, Farina, Piero, additional, Pizzuto, Daniele Antonio, additional, Annunziata, Salvatore, additional, Castello, Angelo, additional, Congedo, Maria Teresa, additional, Tabacco, Diomira, additional, Sassorossi, Carolina, additional, Castellani, Massimo, additional, Nosotti, Mario, additional, Margaritora, Stefano, additional, and Lococo, Filippo, additional

Published
2022
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45. Clinical Stage III NSCLC Patients Treated with Neoadjuvant Therapy and Surgery: The Prognostic Role of Nodal Characteristics

Author

Chiappetta, Marco, primary, Tabacco, Diomira, additional, Iaffaldano, Amedeo Giuseppe, additional, Evangelista, Jessica, additional, Congedo, Maria Teresa, additional, Sassorossi, Carolina, additional, Meacci, Elisa, additional, D’Argento, Ettore, additional, Bria, Emilio, additional, Vita, Emanuele, additional, Tortora, Giampaolo, additional, Boldrini, Luca, additional, Charles-Davies, Diepriye, additional, Massaccesi, Mariangela, additional, Martino, Antonella, additional, Mazzarella, Ciro, additional, Valentini, Vincenzo, additional, Margaritora, Stefano, additional, and Lococo, Filippo, additional

Published
2022
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46. Risk Factors Associated with Post-Operative Complications in Multidisciplinary Treatment of Descending Necrotizing Mediastinitis

Author

Congedo, Maria Teresa, primary, Nachira, Dania, additional, Pennisi, Mariano Alberto, additional, Chiappetta, Marco, additional, Calabrese, Giuseppe, additional, Bello, Giuseppe, additional, Parrilla, Claudio, additional, Franza, Laura, additional, Covino, Marcello, additional, Petracca Ciavarella, Leonardo, additional, Porziella, Venanzio, additional, Vita, Maria Letizia, additional, Lococo, Filippo, additional, Margaritora, Stefano, additional, and Meacci, Elisa, additional

Published
2022
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48. Learning Curve of Robot-Assisted Thymectomy: Single Surgeon's 7-Year Experience

Author

Meacci, Elisa, primary, Nachira, Dania, additional, Congedo, Maria Teresa, additional, Petracca-Ciavarella, Leonardo, additional, Vita, Maria Letizia, additional, Porziella, Venanzio, additional, Chiappetta, Marco, additional, Lococo, Filippo, additional, Tabacco, Diomira, additional, Triumbari, Elizabeth Katherine Anna, additional, and Margaritora, Stefano, additional

Published
2022
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49. Rate and Predictors of Unforeseen PN1/PN2-Disease in Surgically Treated cN0 NSCLC-Patients with Primary Tumor > 3 cm: Nationwide Results from Italian VATS-Group Database

Author

Lococo, Filippo, Nachira, Dania, Chiappetta, Marco, Sperduti, Isabella, Congedo, Maria Teresa, Meacci, Elisa, Leoncini, Fausto, Trisolini, Rocco, Crisci, Roberto, Curcio, Carlo, Casiraghi, Monica, Margaritora, Stefano, and On The Behalf Of The Italian Vats Group, Null

Subjects
surgery, VATS-Group, NSCLC, VATS, nodal upstaging, staging, General Medicine
Abstract

Background. Since no robust data are available on the real rate of unforeseen N1-N2 disease (uN) and the relative predictive factors in clinical-N0 NSCLC with peripheral tumours > 3 cm, the usefulness of performing a (mini)invasive mediastinal staging in this setting is debated. Herein, we investigated these issues in a nationwide database. Methods. From 01/2014 to 06/2020, 15,784 thoracoscopic major lung resections were prospectively recorded in the “Italian VATS-Group” database. Among them, 1982 clinical-N0 peripheral solid-type NSCLC > 3 cm were identified, and information was retrospectively reviewed. A mean comparison of more than two groups was made by ANOVA (Bonferroni correction for multiple comparisons), while associations between the categorical variables were estimated with a Chi-square test. The multivariate logistic regression model and Kaplan–Meyer method were used to identify the independent predictors of nodal upstaging and survival results, respectively. Results. At pathological staging, 229 patients had N1-involvement (11.6%), and 169 had uN2 disease (8.5%). Independent predictors of uN1 were SUVmax (OR: 1.98; CI 95: 1.44–2.73, p = 0.0001) and tumour-size (OR: 1.52; CI: 1.11–2.10, p = 0.01), while independent predictors of uN2 were age (OR: 0.98; CI 95: 0.96–0.99, p = 0.039), histology (OR: 0.48; CI 95: 0.30–0.78, p = 0.003), SUVmax (OR: 2.07; CI 95: 1.15–3.72, p = 0.015), and the number of resected lymph nodes (OR: 1.03; CI 95: 1.01–1.05, p = 0.002). Conclusions. The unforeseen N1-N2 disease in cN0/NSCLCs > 3 cm undergoing VATS resection is observable in between 12 and 8% of all cases. We have identified predictors that could guide physicians in selecting the best candidate for (mini)invasive mediastinal staging.

Published
2023

50. Lymphadenectomy for lung carcinoids: Which factors may predict nodal upstaging? A multi centric, retrospective study

Author

Chiappetta, Marco, Lococo, Filippo, Sperduti, Isabella, Cusumano, Giacomo, Terminella, Alberto, Fournel, Ludovic, Guerrera, Francesco, Filosso, Pierluigi, Tabacco, Diomira, Nicosia, Samanta, Alifano, Marco, Gallina, Filippo, Facciolo, Francesco, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Chiappetta, Marco, Lococo, Filippo, Sperduti, Isabella, Cusumano, Giacomo, Terminella, Alberto, Fournel, Ludovic, Guerrera, Francesco, Filosso, Pierluigi, Tabacco, Diomira, Nicosia, Samanta, Alifano, Marco, Gallina, Filippo, Facciolo, Francesco, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)

Abstract

Objective To investigate risk factors for nodal upstaging in patients with lung carcinoids and to understand which type of lymphadenectomy is most appropriate. Methods Data regarding patients with lung carcinoids, who underwent surgical resection and lymphadenectomy in five institutions from January 1, 2005 to December 31, 2019, were collected and retrospectively analyzed. Clinical and pathological tumor characteristics were correlated to analyze lymph node upstaging. Results The analysis was conducted on 283 patients. Pathology showed 230 typical and 53 atypical carcinoids. Nodal and mediastinal upstaging occurred in 33 (11.6%) and 16 (5.6%) patients, respectively. At the univariable analysis, nodal upstaging was significantly correlated with central location (p = 0.003), atypical histology (p < 0.001), pT dimension (p = 0.004), and advanced age (p = 0.043). The multivariable analysis confirmed atypical histology (odds ratio [OR]: 11.030; 95% confidence interval [CI]: 4.837-25.153, p < 0.001) and central location (OR: 3.295; 95% CI: 1.440-7.540, p = 0.005) as independent prognostic factors for nodal upstaging. Atypical histology (p < 0.001), pT dimension (p = 0.036), number of harvested lymph node stations (p = 0.047), and type of lymphadenectomy (p < 0.001) correlated significantly with mediastinal upstaging. The multivariable analysis confirmed atypical histology (OR: 5.408; 95% CI: 1.391-21.020, p = 0.015) and pT (OR: 1.052; 95% CI: 1.021-1.084, p = 0.001) as independent prognostic factors. Conclusion Atypical histology, dimension, and central location are associated with a high-risk for occult hilo-mediastinal metastases, and mediastinal radical dissection may predict nodal upstaging. Thus, we suggest radical mediastinal lymph node dissection in high-risk tumors, reserving sampling, or lobe-specific dissection in peripheral, small typical carcinoids.

Published
2022

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