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Prior studies have suggested that grit and resilience predict both academic and career success. However, these qualities have not been examined in children with reading disorder (RD). We therefore investigated whether grit and resilience were associated with anxiety, depression, academic performance, and quality of life (QOL) in these students. This 3-year longitudinal cohort study included 163 participants with RD from 3 schools. Evaluations were completed by parents and/or teachers every 3 months. The Grit and Resilience Scale was adapted from the 10-item Connor-Davidson Resilience Scale and the 12-item Grit Scale. Outcome measures included anxiety (School Anxiety Scale - Teacher Report and the 8-item Spence Children's Anxiety Scale), depression (Short Mood and Feelings Questionnaire), academic performance, and QOL (Pediatric QOL Inventory 4.0). Multivariate linear regression models (adjusting for age and sex) assessed the associations at baseline. Repeated measures analysis using mixed-effects models assessed the relationship longitudinally. There were statistically significant associations between grit and resilience and all outcomes at baseline and over time. After adjusting for age and sex, improved grit and resilience was associated with decreased anxiety (β =  - 0.4, p

BACKGROUND: The invasive freshwater snail Pomacea canaliculata is an agricultural pest with a certain level of tolerance to abiotic stress. After the harvest of late rice, the snails usually burrow themselves into the soil surface layers to overwinter and pose a renewed threat to rice production in the following year. Revealing the response of snails to environmental stresses is crucial for developing countermeasures to control their damage and spread. RESULTS: In this study, we conducted a 120‐day in situ experiment during the winter to investigate the survival and physiological changes of hibernating snails in 0‐5 and 5‐10 cm soil depths, aiming to explore their overwintering strategies. Our results showed that 73.61%, 87.50%, and 90.28% of male, female, and juvenile snails survived after hibernation for 120 days in 0–10 cm soil depth, respectively. The differences in survival rates based on sex and size of snails potentially reflect the countermeasures of snails to rapidly reproduce after hibernation. Simultaneously, the hibernating snails exhibited the ability to maintain a certain level of body weight. During this period, the snails increased their antioxidant enzyme activities to cope with oxidative stress, and enhanced their lipid storage. The hibernation survival of snails was not significantly affected by different soil depths, indicating that they have the potential to hibernate into deeper soils. Furthermore, snails were capable of increasing their contents of bound water and glycerol to cope with sudden cold spells during hibernation. CONCLUSION: Our findings emphasize the adaptive changes of P. canaliculata snails overwintering in paddy soils. In future studies, the vulnerabilities of P. canaliculata during hibernation (e.g. shell characteristics, nutrient reserves, and dehydration tolerance, etc.,) should be investigated to develop effective control methods for this period. © 2024 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Cellular senescence (CS) is closely related to tumor progression. However, the studies about CS genes across human cancers have not explored the relationship between cancer senescence signature and telomere length. Additionally, single-cell analyses have not revealed the evolutionary trends of malignant cells and immune cells at the CS level. We defined a CS-associated signature, called "senescence signature", and found that patients with higher senescence signature had worse prognosis. Higher senescence signature was related to older age, higher genomic instability, longer telomeres, increased lymphocytic infiltration, higher pro-tumor immune infiltrates (Treg cells and MDSCs), and could predict responses to immune checkpoint inhibitor therapy. Single-cell analysis further reveals malignant cells and immune cells share a consistent evolutionary trend at the CS level. MAPK signaling pathway and apoptotic processes may play a key role in CS, and senescence signature may effectively predict sensitivity of MEK1/2 inhibitors, ERK1/2 inhibitors and BCL-2 family inhibitors. We also developed a new CS prediction model of cancer survival and established a portal website to apply this model (https://bio-pub.shinyapps.io/cs_nomo/). [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has created significant challenges to the global economy, especially within the tourism industry. Economic downturns and psychological barriers make it even more challenging to attract tourists back. This paper explores the stimulating effect of digital travel vouchers on tourist mobility, as well as the heterogeneous effects of different vouchers modes. Using monthly data on tourist inflows in 306 cities from September 2020 to December 2021, collected by a web-crawling tool, and manually gathered information of digital travel vouchers issued during this period, our analyses show that digital travel vouchers can boost tourist inflows. Their effectiveness, however, depends on the method of issuance and the total number distributed. Furthermore, significant spillover effects among neighboring cities are found through a spatial econometric model. [ABSTRACT FROM AUTHOR]

Pomacea canaliculata was by far one of the most harmful invasive organisms in the world, causing serious harm to aquatic crops and ecosystem. Calcium carbonate is a common component of aquatic environment, which is important for the growth of Pomacea canaliculata. Therefore, the objective of this study was to investigate the response characteristics of P. canaliculata suffered shell breakage to the addition of calcium carbonate in water environment. In this experiment, we explored the effects of calcium carbonate addition on the P. canaliculata shell repair rate, food intake, egg production, shell strength, and calcium content through breaking the snails shell and the addition of calcium carbonate treatment. The results showed that snail broken-shell repaired mostly within 21 days. The snails experienced a significant increase in shell repair rates during earlier days of the treatment, especially for female snails. Food intake of snails exhibited different patterns when their shells were broken and calcium carbonate was added. Shell breakage treatment combined with calcium carbonate addition significantly increased the diameter of snail eggs compared with the control and the calcium carbonate addition treatment without shell-broken snail group. There was no significant difference in shell strength or calcium content of male snails between the treatments. The study suggests that P. canaliculata exhibits a sex-dependent response pattern when subjected to shell damage and calcium carbonate addition. The findings can provide some references to better understand the invasion mechanism and survival strategy of the P. canaliculata. [ABSTRACT FROM AUTHOR]

Endosomal cargo recycling lies at the heart of subcellular trafficking processes under the management of several Ras‐related GTP‐binding proteins (Rabs) which are coordinated by their upstream regulators and require their downstream effectors to display their functions. In this regard, several Rabs have been well‐reviewed except Rab22a. Rab22a is a crucial regulator of vesicle trafficking, early endosome and recycling endosome formation. Notably, recent studies demonstrated the immunological roles of Rab22a, which are closely associated with cancers, infection and autoimmune disorders. This review provides an overview of the regulators and effectors of Rab22a. Also, we highlight the current knowledge of the role of Rab22a in endosomal cargo recycling, including the biogenesis of recycling tubules with the help of a complex with Rab22a at its core, and how different internalized cargo chooses different recycling routes thanks to the cooperation of Rab22a, its effectors and its regulators. Of note, contradictions and speculation related to endosomal cargo recycling that Rab22a brings impacts on are also discussed. Finally, this review endeavors to briefly introduce the various events impacted by Rab22a, particularly focusing on the commandeered Rab22a‐associated endosomal maturation and endosomal cargo recycling, in addition to the extensively investigated oncogenic role of Rab22a. [ABSTRACT FROM AUTHOR]

Apple snails (ASs), the freshwater snails of the family Ampullariidae, are widely spread in tropical and subtropical regions. Owing to their strong invasiveness and harmful effects on agricultural production and ecosystems, they have attracted considerable attention. However, less research has been conducted on the whole picture of the current research status and development trends in the ASs field. For this purpose, we conducted a bibliometric analysis based on a total of 1028 publications regarding ASs published between 1900 and 2021 using VOSviewer 1.6.18 and CiteSpace 6.1.R3 software. The results suggest that ASs research has received increasing attention in recent years. The most productive country has been the USA, while the institution with the most publications was Consejo Nacional de Investigaciones Científicas y Técnicas Conicet. "Zoology" was the category of the most popular subject, Journal of Molluscan Studies was the primary journal, and P.R. Martin was the most outstanding author in ASs field. Invasive alien species, alarm response, copper (Cu) exposure, taxonomy and phylogenetic analysis, Angiostrongylus cantonensis (parasite), control (including molluscicidal activity), growth and reproduction, and feeding preferences were the main research hotspots. Further, "Pomacea maculata", "Evolution", "Biology", "Digestive gland", "Phylogeny", "Identification", "Pomacea canaliculata caenogastropoda", "Diversity", and "Nonnative apple snail" have been emerging active topics in recent years. These findings can help researchers in this area to better understand the direction and advances of ASs research and are valuable for future research and agricultural practice of apple snail control. [ABSTRACT FROM AUTHOR]

1. Describe the geographic distribution of hospice and palliative medicine board-certified physicians and nurse practitioners in the United States. 2. Compare the distribution of hospice and palliative medicine board-certified physicians and nurse practitioners by state, metropolitan status, and area-level socioeconomic status. Our study highlights the ongoing scarcity of palliative care specialists and striking differences in the geographic distribution of board-certified palliative medicine physicians and nurse practitioners based on geography. Disparities in access to palliative care appear to exist based on state, metropolitan status, and area-level socioeconomic status. Access to palliative care is impeded by significant shortages of Hospice and Palliative Medicine (HPM) board-certified physicians and nurse practitioners (NPs). To describe the geographic distribution of HPM board-certified physicians and NPs in the US and compare distribution by state, metropolitan status, and area-level socioeconomic status. We merged the American Board of Medical Specialties HPM physician certification dataset and the Hospice and Palliative Nurses Association nurse practitioner certification dataset, including only those with active certifications in 2022. Based on available data, we mapped physicians by zip code and NPs by city/town (Rural-Urban Commuting Area Codes) to describe the percentage of clinicians in metropolitan areas. We calculated clinician density per state adjusted for population ≥ 65 years (2021 US Administration for Community Living) as a surrogate for palliative care needs. We calculated the Social Deprivation Index (SDI) associated with each physician's zip code and reported percentage of physicians per SDI quintile with lower quintiles indicating lesser deprivation and higher quintiles indicating greater deprivation. In 2022, there were 6,448 (72.2%) active physicians and 2,487 (27.8%) active NPs. More than 90% (n = 8,319) were located in metropolitan areas, and > 50% of physicians were in the two lower SDI quintiles (n = 3,613). Nationally, there was one physician per 8,632 people ≥ 65 years of age and one NP per 22,380 people ≥ 65 years. State-by-state population-adjusted rates of board-certified clinicians per 100,00 people ≥ 65 were highly variable. Our findings highlight geographic differences in the distribution of HPM clinicians with the distribution of NPs mirroring that of physicians, such that NPs may be increasing access in areas where capacity already exists. Clinician density is particularly low in rural areas and areas with higher social deprivation, suggesting disparities in access to palliative care. Scientific Research / Advocacy / Policy/ Regulations [ABSTRACT FROM AUTHOR]