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This article briefly described AI image generation technology and its application advantages in furniture design, and proposes the general processed of AI image generation technology in furniture design. Furniture design was tried based on "text instructions" and used Bauhaus style practical design cases to verify the efficiency of AI image generation technology in assisting in generating furniture design renderings. This results showed that AI image generation technology can be used in the creative stage of furniture design, and played an important role on shortening the furniture design cycle and improving the quality of furniture design. [ABSTRACT FROM AUTHOR]

Hormone therapy (HT) has failed to improve learning and memory in postmenopausal women according to recent clinical studies; however, the reason for failure of HT in improving cognitive performance is unknown. In our research, we found cognitive flexibility was improved by 17β-Estradiol (E2) in mice 1 week after ovariectomy (OVX ST), but not in mice 3 months after ovariectomy (OVX LT). Isobaric tags for relative and absolute quantitation (iTRAQ) revealed increased cannabinoid receptor interacting protein 1 (CNRIP1) in E2-treated OVX LT mice compared with E2-treated OVX ST mice. Adeno-associated virus 2/9 (AAV2/9) delivery of Cnrip1 short-hairpin small interfering RNA (Cnrip1 -shRNA) rescued the impaired cognitive flexibility in E2 treated OVX LT mice. This effect is dependent on CB1 function, which could be blocked by AM251—a CB1 antagonist. Our results indicated a new method to increasing cognitive flexibility in women receiving HT by disrupting CNRIP1. • Estrogen fails to rescue cognitive flexibility in long-term estrogen-deprived female mice. • CNRIP1 protein is increased in long-term estrogen-deprived female mice compared with short-term group. • Disrupting CNRIP1 rescues cognitive flexibility long-term estrogen-deprived female mice after estrogen treatment. [ABSTRACT FROM AUTHOR]

Polyoxometalates (POMs) have good potential for applications in different fields, including conducting materials, optics, and electrocatalysis. Of particular significance is the synthesis and development of addendum POMs. Molybdenum-oxo clusters, which are renowned for their diverse structures and electronic properties, were utilized to facilitate the synthesis of innovative materials. Herein, we employed presynthesized {XW 9 Nb 3 O 40 } (X= Si/Ge) polyanions as secondary building units and different molybdenum-oxo clusters as linkers. Four new addendum POMs were constructed, including two dimeric compounds Cs 10 [H 2 (SiW 9 Nb 3 O 40 ) 2 (Mo 2 O 4 C 2 O 4 )]·19H 2 O ( 1 ) and Cs 8 [H 4 (GeW 9 Nb 3 O 40 ) 2 (Mo 2 O 4 C 2 O 4 )]·17H 2 O ( 2 ), and two tetrameric compounds Cs 15 (NH 4 )[(SiW 9 Nb 3 O 40 ) 4 (Mo 4 O 6 )]·42H 2 O ( 3 ) and Cs 10 K 5 [H(GeW 9 Nb 3 O 40 ) 4 (Mo 4 O 6 )]·39H 2 O ( 4 ). Notably, this is the first report of Mo/W/Nb ternary mixed-addendum POMs. In addition, compounds 3 and 4 facilitate the transfer of protons through extended hydrogen-bonding networks with conductivity values of 1.16 × 10 -2 and 7.73 × 10 -3 S·cm -1 at 85 °C and 98% relative humidity, respectively. Furthermore, no discernible decline in conductivity was noted over the course of 10 h.

Copper-catalysed radical-relay reactions that employ N -fluorobenzenesulfonimide (NFSI) as the oxidant have emerged as highly effective methods for C(sp 3 )-H functionalization. Herein, computational studies are paired with experimental data to investigate a series of key mechanistic features of these reactions, with a focus on issues related to site-selectivity, enantioselectivity, and C-H substrate scope. (1) The full reaction energetics of enantioselective benzylic C-H cyanation are probed, and an adduct between Cu and the N -sulfonimidyl radical (˙NSI) is implicated as the species that promotes hydrogen-atom transfer (HAT) from the C-H substrate. (2) Benzylic versus 3° C-H site-selectivity is compared with different HAT reagents: Cu/˙NSI, ˙O t Bu, and Cl˙, and the data provide insights into the high selectivity for benzylic C-H bonds in Cu/NFSI-catalyzed C-H functionalization reactions. (3) The energetics of three radical functionalization pathways are compared, including radical-polar crossover (RPC) to generate a carbocation intermediate, reductive elimination from a formal Cu III organometallic complex, and radical addition to a Cu-bound ligand. The preferred mechanism is shown to depend on the ligands bound to copper. (4) Finally, the energetics of three different pathways that convert benzylic C-H bonds into benzylic cations are compared, including HAT/ET (ET = electron transfer), relevant to the RPC mechanism with Cu/NFSI; hydride transfer, involved in reactions with high-potential quinones; and sequential ET/PT/ET (PT = proton transfer), involved in catalytic photoredox reactions. Collectively, the results provide mechanistic insights that establish a foundation for further advances in radical-relay C-H functionalization reactions., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Objective: To compare the posterior cruciate ligament(PCL) index with six different measurement methods, and analyze and verify its clinical diagnostic value in anterior cruciate ligament (ACL) injury., Methods: The Magnetic resonance imaging (MRI) data of 225 knee joints in our hospital from May 2018 to March 2022 were retrospectively analyzed, aged from 18 to 60 years old, with a median of 32 years old. On the sagittal MRI images of 114 patients with ACL injury and 111 patients with intact ACL, Measure the straight-line distance (A) between the femoral attachment point and the tibial attachment point of the PCL on the MRI sagittal image and the maximum vertical distance (B) between the straight line and the arcuate mark point of the PCL on the sagittal image, calculate the PCL index and evaluate the diagnostic value of the PCL index for ACL injury., Results: The PCL index of the ACL normal group and the ACL injury group were statistically described. There was no significant difference in PCL index 1, 2, 3 and 6 between the two groups( P >0.05). The difference of PCL index 4 and 5 between the two groups was statistically significant ( P <0.001). This study only found that the PCL index 2, 6 in the ACL normal group had a negative correlation with the patient's age (correlation coefficient=-0.213, -0.819; P <0.05), and the PCL index 5 in the ACL injury group was significantly correlated with the patient's body mass index(BMI)had a negative correlation (correlation coefficient=-0.277, P <0.05)., Conclusion: The change of PCL index is helpful for the diagnosis of ACL injury, PCL index 4 and 5 can be used as effective reference indexes for diagnosing ACL injury in clinic.